Archive for the ‘Gene therapy’ Category

Critical Variables affecting clinical-grade production of the self-inactivating gamma-retroviral vector for the treatment of X-linked severe combined immunodeficiency

Sunday, May 6th, 2012

Authors: J C M van der Loo, W P Swaney, E Grassman, A Terwilliger, T Higashimoto, A Schambach, S Hacein-Bey-Abina, D L Nordling, M Cavazzana-Calvoo, A J Thrasher, D A Williams, L Reeves & P Malik (Source: Gene Therapy)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml

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HIV Gene Therapy Safe Over Time (CME/CE)

Sunday, May 6th, 2012

(MedPage Today) — A gene therapy approach to HIV treatment is long-lasting and safe, researchers reported. (Source: MedPage Today Infectious Disease) MedWorm Sponsor Message: Please have a look at this new site driven by MedWorm: The Breast Cancer Daily Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml

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Nanovector delivery of siRNA for cancer therapy

Sunday, May 6th, 2012

Authors: H Shen, T Sun & M Ferrari (Source: Cancer Gene Therapy)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml

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Gene Hunt Is On for Mental Disabilities in Children

Sunday, May 6th, 2012

By Ewen Callaway of Nature magazine [More] Source:http://rss.sciam.com/sciam/topic/gene-therapy

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April 2012 Advances: Additional Resources

Sunday, May 6th, 2012

The Advances news section in April's issue of Scientific American included stories on digital textbooks, the promise of using gene therapy to fight blindness and how fragile orchids survive. To learn more about any of the stories, follow these links. [More] Source:http://rss.sciam.com/sciam/topic/gene-therapy

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Genetically modified T cell therapy shown to be safe, lasting in decade-long study of HIV patients

Friday, May 4th, 2012

Public release date: 2-May-2012 [ | E-mail | Share ] Contact: Holly Auer holly.auer@uphs.upenn.edu 215-200-2313 University of Pennsylvania School of Medicine PHILADELPHIA — HIV patients treated with genetically modified T cells remain healthy up to 11 years after initial therapy, researchers from the Perelman School of Medicine at the University of Pennsylvania report in the new issue of Science Translational Medicine. The results provide a framework for the use of this type of gene therapy as a powerful weapon in the treatment of HIV, cancer, and a wide variety of other diseases.

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Families of SMA Awards New Funding to Advance a CNS Delivered Gene Therapy for Spinal Muscular Atrophy

Friday, May 4th, 2012

ELK GROVE VILLAGE, Ill., May 2, 2012 (GLOBE NEWSWIRE) — Families of SMA is pleased to announce the award of up to $750,000 for an important new grant to Dr. Brian Kaspar at Nationwide Children’s Hospital.

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A Media Event on Clinical Developments in Gene and Cell Therapy

Friday, May 4th, 2012

Academic and industry leaders in gene and cell therapy will be featured at a Media Event in Philadelphia, PA on May 15, 2012, immediately preceding the 15th Annual Meeting of the American Society of Gene and Cell Therapy (ASGCT) on May 16-19, 2012.Milwaukee, WI (PRWEB) May 02, 2012 Academic and industry leaders in gene and cell therapy will be featured at a Media Event in Philadelphia, PA on May …

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Generational Achievements in Gene and Cell Therapy Honored at ASGCT 15th Annual Meeting

Friday, May 4th, 2012

The American Society of Gene & Cell Therapy is pleased to honor Dr. David Williams, MD, as the recipient of the Outstanding Achievement Award at the Society’s 15th Annual Meeting on Saturday, May 19th.Milwaukee, WI (PRWEB) May 04, 2012 Pioneering researcher recognized for scientific achievements in gene and cell therapyThe American Society of Gene & Cell Therapy is pleased to honor Dr. David …

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A Step Forward For Gene Therapy To Treat HIV

Friday, May 4th, 2012

PLoS Biology HIV particles assemble at the surface of a white blood cell called a macrophage. Millions of people around the world are living with HIV, thanks to drug regimens that suppress the virus

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Gene therapy for HIV safe, but effectiveness still unclear

Friday, May 4th, 2012

By Randy Dotinga HealthDay Reporter WEDNESDAY, May 2 (HealthDay News) — New research shows that gene therapy can have long-lasting effects on the immune cells of HIV patients — a promising sign — even though the specific treatment being studied did not eradicate the virus. This approach is one of several gene therapy strategies that are being investigated by scientists as possible ways to keep the AIDS virus from spreading in the blood. In this case, “people were treated by gene therapy and nothing bad happened.

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Study: Gene Therapy for HIV Safe, But Effectiveness Still Unclear

Friday, May 4th, 2012

WEDNESDAY, May 2 (HealthDay News) — New research shows that gene therapy can have long-lasting effects on the immune cells of HIV patients — a promising sign — even though the specific treatment being studied did not eradicate the virus.

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Gene Therapy Safe in Decade-Long HIV Study That May Widen Use

Friday, May 4th, 2012

By Elizabeth Lopatto – Wed May 02 18:00:00 GMT 2012 HIV patients given gene therapy more than a decade ago are healthy and the altered DNA they received remains stable in their bodies, according to a study that scientists say proves the treatment may safely be tested as a way to attack other illnesses. All except two of 43 people treated with genetically- altered versions of their own infection-fighting T cells were healthy as many as 11 years later, according to the research reported today in the journal Science Translational Medicine

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Gene Therapy Convention I-SMART on May 2nd 2012, 4 PM to 7 PM, at Bangalore Under the Aegis of DRDO, DST, Dr.Agarwal …

Monday, April 30th, 2012

BANGALORE, India, April 30, 2012 /PRNewswire/ — I-SMART (Indian Society For Molecular Advanced Regenerative Technologies) a conglomerate of Indian scientists from DRDO, DST, Dr.Agarwal Hospitals, Manacells, Gene Research Foundation has organized the first Gene Therapy Convention to be held at Bangalore on May 2nd 2012.

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Calcium carbonate microparticles used as a gene vector for delivering p53 gene into cancer cells.

Sunday, April 29th, 2012

In this study, CaCO(3) delivering pEGFP-C1-p53 could transfect about 5% of the tumor cells in culture. However, the efficiency of tumor cell apoptosis was surprisingly up to 80%. Meanwhile, the results of MTT assay and crystal violet staining showed that the CaCO(3) microparticles had low cytotoxicity. These findings showed that CaCO(3) microparticles were perspective to [...]

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A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications

Sunday, April 29th, 2012

Molecular imaging is revolutionizing the way we study the inner workings of the human body, diagnose diseases, approach drug design, and assess therapies. The field as a whole is making possible the visualization of complex biochemical processes involved in normal physiology and disease states, in real time, in living cells, tissues, and intact subjects. In [...]

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Adeno-associated virus-mediated doxycycline-regulatable TRAIL expression suppresses growth of human breast carcinoma in nude mice

Sunday, April 29th, 2012

Conclusion: These data suggest that rAAV-mediated soluble TRAIL expression under the control of the Tet-On system is a promising strategy for breast cancer therapy. (Source: BMC Cancer)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml

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Epirubicin potentiates recombinant adeno?associated virus type 2/5–mediated TRAIL expression in fibroblast?like synoviocytes and augments the antiarthritic effects of rAAV2/5?TRAIL

Sunday, April 29th, 2012

ConclusionThese results suggest that epirubicin enhances the antiarthritic effect of rAAV2/5?TRAIL and that combination treatment might be an important therapeutic alternative, with practical significance for rheumatoid arthritis. (Source: Arthritis and Rheumatism)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml

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CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results

Sunday, April 29th, 2012

In conclusion, adoptive immunotherapy with CD20-specific T cells was well tolerated and was associated with antitumor activity. We will pursue alternative gene transfer technologies and culture conditions in future studies to improve CAR expression and cell production efficiency. This study is registered at www.clinicaltrials.gov as NCT00621452. (Source: Blood) MedWorm Sponsor Message: Please have a look [...]

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Prospects for gene transfer for clinical heart failure

Sunday, April 29th, 2012

Authors: T Tang, M H Gao & H Kirk Hammond (Source: Gene Therapy)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml

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