Global 'longevity hotspots': What's the secret of these blue zones? Genetic Literacy Project
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Global 'longevity hotspots': What's the secret of these blue zones? - Genetic Literacy Project
BOSTON and HOUSTON, Dec. 04, 2023 (GLOBE NEWSWIRE) -- imaware, a digital health platform company powering home-testing for healthcare brands, and binx health, a molecular diagnostics and consumer testing company, today announced that imaware has acquired binx health’s at-home consumer testing business. The acquisition will expand imaware’s position in the growing market for home-health testing and expand the number of enterprise clients being serviced by imaware. binx health will retain and continue to grow its point-of-care molecular diagnostics business, which is excluded from the imaware transaction.
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imaware acquires binx health’s consumer testing business, becoming a leader in STI health screening
Ms. Alicia Grande, Catalyst's Current CFO, to Retire at the End of 2023
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Catalyst Pharmaceuticals Announces Appointment of Michael W. Kalb as Chief Financial Officer and Other Executive Promotions
NEW YORK, Dec. 04, 2023 (GLOBE NEWSWIRE) -- Sunshine Biopharma, Inc. (NASDAQ: “SBFM”) (the “Company”), a pharmaceutical company offering and researching life-saving medicines in a variety of therapeutic areas including oncology and antivirals today announced that it has moved its headquarters to New York City. The Company’s Head Office is now located at 1177 Avenue of the Americas, 5th Floor, New York, NY 10036 (Tel: 332-216-1147). The Company will maintain a satellite office at its previous headquarters in Montreal (Canada) at 6500 Trans-Canada Highway, 4th Floor, Pointe-Claire, Quebec, Canada, H9R 0A5 (Tel: 514-426-6161). The Company’s email address (info@sunshinebiopharma.com) and URL (www.sunshinebiopharma.com) have not changed.
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Sunshine Biopharma Moves Principal Office to New York City
– CorMedix to advocate for patient safety and infection prevention as part of Leapfrog’s Partners Advisory Committee
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CorMedix Inc. Announces Partnership With The Leapfrog Group
Confirmed partial responses without dose-limiting toxicities during dose escalation along with new preclinical data support the opportunity to further enhance efficacy through a novel split daily dosing regimen at higher dose levels of Nana-val
- Independent Data Monitoring Committee (IDMC) Recommended Continuation of Phase 3 REGAL Trial Without Any Modifications -
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SELLAS Life Sciences Announces Positive Recommendation from REGAL Independent Data Monitoring Committee of Galinpepimut-S in Acute Myeloid Leukemia
- Pre-NDA Meeting to discuss requirements for a 505(b)(2) NDA submission for IkT-001Pro in up to eight blood and stomach cancer indications -
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Inhibikase Therapeutics Granted Pre-NDA Meeting with the FDA for IkT-001Pro
Technological advances reduce time and increase efficiency for MDD treatment Technological advances reduce time and increase efficiency for MDD treatment
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NeuroStar TMS Receives Expanded Regulatory Approval in Japan
Holliston, MA, Dec. 04, 2023 (GLOBE NEWSWIRE) -- Harvard Apparatus Regenerative Technology, Inc. (OTCQB: HRGN) (“Harvard Apparatus Regenerative Technology” or the “Company”), a clinical-stage biotechnology company developing the technology to regenerate organs inside the body to treat severe diseases, today announced that it officially executed a Sponsored Research Agreement (SRA) with Hugh Taylor, MD, chair of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine. The program will focus on the use of Harvard Apparatus Regenerative Technology’s cell-based scaffold platform to restore fertility by repairing uterine tissue in a mouse model of uterine damage.
PALO ALTO, Calif., Dec. 04, 2023 (GLOBE NEWSWIRE) -- Scilex Holding Company (Nasdaq: SCLX, “Scilex” or “Company”), an innovative revenue-generating company focused on acquiring, developing and commercializing non-opioid pain management products for the treatment of acute and chronic pain, today announced that the State of Tennessee added ZTlido® as a preferred agent to the Medicaid Preferred Drug List effective as of October 1, 2023.1 This change has the potential to improve access to ZTlido® for all eligible patients which includes approximately 1,500,000 adult lives between the ages of 19 to 64.1
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Scilex Holding Company announces the addition of ZTlido® (lidocaine topical system) as a preferred agent to the Medicaid Preferred Drug List (PDL) of...
BRISBANE, CALIFORNIA, Dec. 04, 2023 (GLOBE NEWSWIRE) -- GT Biopharma, Inc. (NASDAQ: GTBP), a clinical stage immuno-oncology company focused on developing innovative therapeutics based on the Company's proprietary natural killer (NK) cell engager, TriKE® platform, today announced the submission of an Investigational New Drug (IND) application with the US Food and Drug Administration (FDA) for the development of GTB-3650, a 2nd generation nanobody TriKE® for the treatment of patients with CD33+ leukemia, including relapsed/refractory acute myelogenous leukemia (AML) and high-risk myelodysplastic syndrome (MDS).
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GT Biopharma Announces IND Submission for GTB-3650 for Treatment of CD33+ Leukemia
Taking years off your age? This Israeli expert says its all up to you Haaretz
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Taking years off your age? This Israeli expert says its all up to you - Haaretz
image:The ARDD Meeting 2022 will be hosted on August 29 - September 2, 2022 view more
Credit: Insilico Medicine Hong Kong Limited
March 31, 2022 -- Joris Deelen, Ph.D., will present the latest research on the topic Identification and functional characterisation of genetic variants linked to human longevity at the worlds largest annual Aging Research and Drug Discovery conference (9th ARDD). Dr. Joris Deelen is the Research Group Leader at the Max Planck Institute for Biology of Ageing.
"Previous research on the genetics of human longevity has shown that this trait is likely mainly determined by rare genetic variants. Therefore, the work in my group is currently focused on the functional characterisation of rare genetic variants identified in long-lived individuals. I recently obtained an ERC Starting Grant and a Longevity Impetus Grant to support this work." said Joris Deelen, Ph.D., Research Group Leader at the Max Planck Institute for Biology of Ageing.
Joris Deelen obtained his Ph.D. at the Leiden University Medical Center in the Netherlands in2014. In 2016, he joined the Max Planck Institute for Biology of Ageing as a postdoctoralresearcher where he was promoted to Research Group Leader in 2020. The work in his groupfocusses on the establishment of novel human aging studies in Cologne to determine theefficacy of previously identified biomarkers of aging in clinical studies. The main focus is onbiomarkers that have been identified in large-scale international collaborations of human studies using omics-based approaches, such as metabolomics.
The conference proceedings of the ARDD are commonly published in peer-reviewed journals with the talks openly available at http://www.agingpharma.org. Please review the conference proceedings for 2019, 2020 and 2021https://www.aging-us.com/article/203859/text .
Aging is emerging as a druggable condition with multiple pharmaceuticals able to alter the pace of aging in model organisms. The ARDD brings together all levels of the field to discuss the most pressing obstacles in our attempt to find efficacious interventions and molecules to target aging. The 2022 conference is the best yet with top level speakers from around the globe. Im extremely excited to be able to meet them in person at the University of Copenhagen in late summer. said Morten Scheibye-Knudsen, MD, Ph.D., University of Copenhagen.
Aging research is growing faster than ever on both academia and industry fronts. The ARDD meeting unites experts from different fields and backgrounds, sharing with us their latest groundbreaking research and developments. Our last ARDD meeting took place both offline and online, and it was a great success. I am particularly excited that being a part of the ARDD2022 meeting will provide an amazing opportunity for young scientists presenting their own work as well as meeting the experts in the field. said Daniela Bakula, Ph.D., University of Copenhagen.
Many credible biopharmaceutical companies are now prioritized aging research for early-stage discovery or therapeutic pipeline development. It is only logical to prioritize therapeutic targets that are important in both aging and age-associated diseases. The patient benefits either way. The best place to learn about these targets is ARDD, which we organize for nine years in a row. This conference is now the largest in the field and is not to be missed, said Alex Zhavoronkov, Ph.D., founder and CEO of Insilico Medicine and Deep Longevity.
Building on the success of the ARDD conferences, the organizers developed the Longevity Medicine course series with some of the courses offered free of charge at Longevity.Degree covered in the recent Lanced Healthy Longevity paper titled Longevity medicine: upskilling the physicians of tomorrow.
About Aging Research for Drug Discovery Conference
At ARDD, leaders in the aging, longevity, and drug discovery field will describe the latest progress in the molecular, cellular and organismal basis of aging and the search for interventions. Furthermore, the meeting will include opinion leaders in AI to discuss the latest advances of this technology in the biopharmaceutical sector and how this can be applied to interventions. Notably, this year we are expanding with a workshop specifically for physicians where the leading-edge knowledge of clinical interventions for healthy longevity will be described. ARRD intends to bridge clinical, academic and commercial research and foster collaborations that will result in practical solutions to one of humanity's most challenging problems: aging. Our quest? To extend the healthy lifespan of everyone on the planet.
About Scheibye-Knudsen Lab
In the Scheibye-Knudsen lab we use in silico, in vitro and in vivo models to understand the cellular and organismal consequences of DNA damage with the aim of developing interventions. We have discovered that DNA damage leads to changes in certain metabolites and that replenishment of these molecules may alter the rate of aging in model organisms. These findings suggest that normal aging and age-associated diseases may be malleable to similar interventions. The hope is to develop interventions that will allow everyone to live healthier, happier and more productive lives.
About Deep Longevity
Deep Longevity has been acquired by Edurance RP (SEHK:0575.HK), a publicly-traded company. Deep Longevity is developing explainable artificial intelligence systems to track the rate of aging at the molecular, cellular, tissue, organ, system, physiological, and psychological levels. It is also developing systems for the emerging field of longevity medicine enabling physicians to make better decisions on the interventions that may slow down, or reverse the aging processes. Deep Longevity developed Longevity as a Service (LaaS) solution to integrate multiple deep biomarkers of aging dubbed "deep aging clocks" to provide a universal multifactorial measure of human biological age. Originally incubated by Insilico Medicine, Deep Longevity started its independent journey in 2020 after securing a round of funding from the most credible venture capitalists specializing in biotechnology, longevity, and artificial intelligence. ETP Ventures, Human Longevity and Performance Impact Venture Fund, BOLD Capital Partners, Longevity Vision Fund, LongeVC, co-founder of Oculus, Michael Antonov, and other expert AI and biotechnology investors supported the company. Deep Longevity established a research partnership with one of the most prominent longevity organizations, Human Longevity, Inc. to provide a range of aging clocks to the network of advanced physicians and researchers. https://longevity.ai/
About Endurance RP (SEHK:0575.HK)
Endurance RP is a diversified investment group based in Hong Kong currently holding various corporate and strategic investments focusing on the healthcare, wellness and life sciences sectors. The Group has a strong track record of investments and has returned approximately US$298 million to shareholders in the 21 years of financial reporting since its initial public offering. https://www.endurancerp.com
Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.
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Joris Deelen to present at the 9th Aging Research & Drug Discovery Meeting 2022 - EurekAlert
Texas is a huge beef state. In fact, it is one of the leading beef-producing states in the country. Right here in Victoria County alone, we have about 60,000 mother cows in production that add about $30 million to the agricultural income. All these mother cows require the right genetics to produce and achieve herd goals.
Many folks overlook the importance of bull genetics, and selection is crucial for herd genetic success. You cant tell everything you need to know about a bull just by looking at him. There are more tools than ever at your disposal in the beef industry. We will explore just a few in this article.
When looking for a new herd sire, many bull buyers get lost in all the data and acronyms that go along with selling purebred bulls today. In the past, most buyers evaluated bulls just by looking at them or by comparing them with other bulls in the pen. Today, bull breeders have a lot more data to offer buyers who want it, in addition to those who still like to just look.
Initially, that data included birth, weaning and yearling weight, adjusted for the sex of the calf; since males are heavier, and for the age of dam, due to the influence of milk production higher in older cows, lower in younger ones. Similarly, records on other traits such as carcass, fertility, longevity and docility were also collected.
About 60 years ago, it was realized that bulls and females could be evaluated for their actual genetic value in these traits. Each animal in the breed could be selected on their true genetic merit. These values were called Expected Progeny Differences or EPD. The EPD is calculated for each trait and for each animal in the breed. The EPD is reported in the units of the trait measured, for example pounds for weight. Each EPD also has an accuracy value that tells you how close the EPD really is to the animals true genetic value. It has made accurate selection to improve performance very easy.
Using DNA, beef cattle geneticists have been using genetic markers to improve the accuracy of the EPDs from young animals, especially young bulls, so that they can be selected earlier for traits of importance. They are called Genomic EPD or GE-EPD. Now, even young animals can be selected and used reliably to improve our genetics. This earlier selection also reduces bull development costs since the better bulls are identified earlier and more average and below average bulls are culled. Selecting younger bulls will improve selection success by reducing the amount of time between when a bull is selected for breeding and his calves actually hit the ground.
Select bulls using EPDs to improve traits that are of economic value to your operation. Select bulls that have a good health program and have passed a breeding soundness examination.
For more information, please call the Victoria County Extension Office at (361) 575-4581.
Matt Bochat is a County Extension Agent Ag/Natural Resources Victoria County Texas A&M Agrilife Extension.
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Herd genetics begins with the bull | Agriculture | victoriaadvocate.com - Victoria Advocate
LeBron James has had a spectacular individual season, despite what his team record states at the moment. The Lakers are well under .500 and are at massive risk for missing the play-in tournament, which is their only chance at making the playoffs. For a player at age 37, the goal would be to win at least one more championship before returning. But LeBron James is no ordinary player, and certainly no ordinary 37-year-old.
The King already has 4 NBA championships to his name, and even if he does not win another one, he is already one of the top-5 players to have ever played the game. After all, look at his incredible career. James has won 4 titles, 4 Finals MVPs, 4 MVPs, and made a spectacular 18 All-Star appearances. No player has been great for as long as LeBron has, a testament to his ability to take care of his body and also his almost inhuman genetics.
As a result, LeBron James is considered the single greatest player of all time to much of the younger audience. While Michael Jordan tends to dominate the GOAT debates, LeBron James certainly has his supporters, and for good reason. Recently, we saw LeBron James pass Karl Malone to become the 2nd greatest scorer in NBA history. He is getting closer to Kareem Abdul-Jabbar at the top spot, and he will likely pass the legendary center next year.
If LeBron James becomes the all-time leading scorer, his status in the GOAT debate greatly increases and he might have an even stronger argument for being the greatest player ever, and here are the reasons why.
Other than LeBron James, Kareem Abdul-Jabbar is the name most mentioned when discussing the greatest challenges to Micahel Jordans throne as the GOAT. While his 6 NBA titles and 6 MVPs are his greatest achievements, the fact that he is the all-time leading scorer tends to boost him in the rankings. For LeBron James, having his name etched in record books for being the all-time leading scorer is the single greatest advertisement for the legendary player.
The reason is simple. Even for the millions of people who are not aware of professional basketball, seeing LeBron James holding the number one spot among all-time scorers would convince them that he is the greatest ever without looking into details. Of course, LeBrons career is also backed up with other extraordinary achievements. Shaquille ONeal mentioned it himself, if and when LeBron James becomes the all-time leading scorer in NBA history, he should be considered the GOAT.
As reported, Shaquille O'Neal says LeBron James can become the GOAT if he surpasses Kareem Abdul-Jabbar on the all-time scoring list:
Hes got four rings and he becomes the highest scorer in the NBA history. Hes the best ever, ONeal said. Aint nothing you can say.
Shaq continued:
I know what hes doing, ONeal said while eating some roast beef. Championships are great, but hes trying to pass Kareem up. Thats what he is doing. I know exactly what hes doing. Cause now if you pass Kareem up, it aint no talk about who the best player ever is.
Basketball is about scoring more points than the opponent, and if LeBron did that better than everyone else, he will convince millions of people he is the GOAT.
No player in NBA history has played so well for so long as the great LeBron James. The King is in his 19th season and is averaging the third-most points of his career at age 37. James is not only an elite scorer and passer but always seems to find ways to dominate a game and control the outcome. Most pundits and fans refer to Kareem Abdul-Jabbar as the man who played so well into his late 30s and early 40s, but LeBron James has surpassed him in that regard.
The King always seems to find a way to have his name in the record books and is also competing for the scoring title alongside Joel Embiid and Giannis Antetokounmpo. LeBron is somehow playing as if he is 10 years younger on the offensive end of the court, and is putting up spectacular performance after spectacular performance. We will never see the likes of LeBron James again, and his incredible longevity keeps boosting his status in the eyes of casual fans and younger audiences who are becoming more aware of professional basketball.
LeBron James becoming the all-time leading scorer would be a great thing for his career, because it will give him an amazing addition to an untouchable resume. James has 4 NBA titles and 4 Finals MVPs with 3 teams, the only player to ever achieve that. He will also become the all-time leading scorer and the only player in the exclusive 10k points, 10k assists, and 10k rebounds club. James also has 4 MVP awards (tied for 3rd most) and 18 All-Star appearances (tied for 1st alongside Kareem Abdul-Jabbar).
The King also has 17 All-NBA appearances which will be 18 by the end of the year, which is already the most in NBA history. Adding in a scoring title, and possibly a second one coming this year, LeBron is in a league of his own when it comes to longevity awards and accolades. Even if LeBron James played so long at such a high level, he has somehow dominated the game better than everyone else at his age and experience level.
It will also be extremely impressive if James is able to capture his second scoring title at age 37, along with the all-time record next year. LeBron is not considered a natural scorer, yet still broke records by scoring the ball at an elite level at his age and breaking the record for most points scored. LeBron has also spoken about how he feels disrespected as an all-time great scorer during an episode of The Shop:
When they talk about the best scorers of all time, they never mention my name, James said during the shows episode. It pisses me off.
Clearly, James is not happy bout being disrespected as a scorer, even if he is one of the most unselfish superstars ever:
Im not like a natural scorer, James explained. I love getting my guys involved, Ive always been that way.
The King can also find solace in the fact that by breaking the all-time scoring record, his name will have to be mentioned alongside Michael Jordan, Kobe Bryant, and Kareem Abdul-Jabbar as the most dominant scorer ever whether he is naturally inclined to score or not.
To many fans, especially the younger audiences, LeBron James is already the GOAT without the all-time record in points scored. But capturing that record would convince many more people that we are witnessing the best player ever because that is yet another unbreakable record to his name. Being 1st in points scored, 1st in All-NBA selections, 2nd in All-Star selections, 2nd in Finals MVP awards, and 3rd in MVP awards is truly astonishing because he is in a league of his own.
Even if there are people who are not convinced that James is the GOAT, there is no doubt a lot of them will admit that The King will surpass a ton of competitors such as Kareem Abdul-Jabbar once he claims the scoring record. As mentioned, Kareem Abdul-Jabbar is the name most mentioned when discussing the greatest challenges to Micahel Jordans throne as the GOAT. Kareems all-time scoring record tends to boost him in the rankings, an achievement that will firmly belong to James. With Kareem out of the way, there is only one man standing in James way before becoming the GOAT, Michael Jordan.
Obviously, Michael Jordan did not play as long as LeBron James. The Chicago Bulls legend missed out on 4 NBA seasons due to 2 separate retirement phases, and he even only played 17 games following his first season back from his first retirement. That meant, Jordan only had 12 NBA seasons where he was playing consistent basketball at a professional level. That is way off the 19 seasons that LeBron has played, which is why he fails to compare in many of the longevity accolades.
James has more All-Star appearances (18 vs. 14), more All-NBA appearances (17 vs. 11), and is also a greater all-time scorer. These accolades are hard to argue against because it shows LeBron James had a longer sustained career than the legendary Bulls guard. Of course, Jordan supporters will be quick to point out that James does not have as many championships and Finals MVPs as Jordan (6 vs. 4).
While James will likely never catch Jordan in championships won, he has surpassed him in almost every other individual category pertaining to longevity. He is not the scorer that Jordan is as a purely offensive weapon (Jordan has 10 scoring titles), but James has more total points scored and more total stat totals including assists and rebounds. While there will be a massive portion of the NBA fanbase who will prefer Jordans 6 NBA titles, LeBrons scoring record adds yet another unbreakable record to The Kings name.
LeBron James: 4
Michael Jordan: 6
There arent many winners better than Michael Jordan, as he ranks 6th all-time in championships won as a player. Of course, he always performed on the brightest stage of them all and it is likely that LeBron James will never catch Jordan. The King does have 4 titles with 3 teams, meaning he had to move around the league a few times to win them.
LeBron James: 4
Michael Jordan: 6
With Jordan being the best player in every Finals series he played in, he has the edge in Finals MVPs as well. MJ dominated the Finals, never competing in a Game 7 and killing off the competition in 6 games and less. LeBron was also the best player in the series he played in, capturing 4 Finals MVPs in his Finals appearances, although he holds a poor 4-6 record.
LeBron James: 4
Michael Jordan: 5
LeBron James probably should have won more MVP awards, because he is arguably the greatest regular-season player considering his statistics and accolades. The same could be said for Michael Jordan because he was arguably the best player in the league by the end of his first season. James cuts it close, but once again, MJ has the nod in another accolade.
LeBron James: 0
Michael Jordan: 1
LeBron James was an elite defender in his prime, showcasing his talent on the defensive end when he played for the Miami Heat alongside two other All-Stars. Thanks to the presence of Dwyane Wade and Chris Bosh, James was able to focus on defense a little bit more and could defend all five positions when asked to. But he is not Michael Jordan on defense, and quite frankly, very few are. Jordan captured the elusive Defensive Player of the Year award while James has not.
LeBron James: 1
Michael Jordan: 10
LeBron James could earn the scoring title this year, a great achievement for a pass-first player as he will join the likes of Kobe Bryant, Shaquille ONeal, and Carmelo Anthony with two. But he is well off of Jordans 10 scoring titles, and nobody except Wilt Chamberlain (7) comes close. We will never see a dominant scorer like Mike again, and he has the edge over The King.
LeBron James: 18
Michael Jordan: 14
LeBron James has had a longer career and is the greatest 37-year-old player ever. No player has played as great for as long as LeBron, and he has a whopping 18 All-Star appearances. Only Kareem Abdul-Jabbar has more with 19. Jordan had 14 All-Star appearances, a respectable number, but he did not play as long as The King.
LeBron James: 17
Michael Jordan: 11
LeBron James will likely make his 18th All-NBA Team appearance this season, and he is already in a league of his own. Kobe Bryant, Tim Duncan, and Kareem Abdul-Jabbar all have 15 All-NBA appearances, meaning James is the leading man by far. Jordan only has 11 All-NBA appearances, mainly because he did not last 19 seasons at a superstar level as LeBron did. James has the nod in a very important category here.
LeBron James: 6
Michael Jordan: 9
LeBron was a defensive beast in his prime, but he never really had sustained excellence on that end of the floor as MJ did. Jordan made 9 All-Defensive Teams, and only 5 players had more (Tim Duncan, Kevin Garnett, Kobe Bryant, Kareem Abdul-Jabbar, and Scottie Pippen). Once again, James was excellent defensively but Jordan was the better defender.
LeBron James: 3
Michael Jordan: 3
LeBron James is one of the greatest All-Star Game performers, capturing the MVP award 3 times. Michael Jordan also captured the All-Star Game MVP 3 times, meaning he and LeBron James are tied for 2nd all-time with Oscar Robertson and Shaquille ONeal joining them. Only Kobe Bryant and Bob Pettit are ahead of them with 4 awards.
LeBron James: 1
Michael Jordan: 1
LeBron James had one of the best rookie seasons ever, considering the extreme pressure on The King. At age 19, James dropped averages of 20.9 PPG, 5.5 RPG, and 5.9 APG and certainly met expectations by winning Rookie of the Year. Jordan also won Rookie of the Year, posting sublime averages of 28.2 PPG, 6.5 RPG, and 5.9 APG. No doubt, Jordan had the better rookie season.
LeBron James: 37,024
Michael Jordan: 32,292
Michael scored over 32k points in his career and did the bulk of the damage during his incredible 13-year span before his second retirement. Had he played longer without missing nearly 5 seasons with retirement, Jordan could have broken Kareem Abdul-Jabbars record. But LeBron has played longer and has been at an elite level for 19 seasons, as he has more points than MJ.
LeBron James: 10,202
Michael Jordan: 6,672
The King is a 69 behemoth so it is natural for him to have more total rebounds than Michael Jordan. James has a career average of 7.5 RPG, ahead of Michael Jordans average of 6.2 RPG. Over 19 seasons, James has accumulated over 10,000 rebounds as he is part of the exclusive 10k points, 10k rebounds, and 10k assists club. Michael had over 6,000 rebounds in his own career but falls short of James.
LeBron James: 10,041
Michael Jordan: 5,633
As one of the most talented passers ever and a natural playmaker, LeBron James has almost doubled the number of assists as MJ. The King is a pass-first player and is among the best floor generals to have ever played the game. MJ hardly had any weaknesses as a player, but his playmaking is the closest to a weakness. Not because he could not pass, but because he was a natural scorer with the ability to take every shot down the floor.
LeBron James: 2,135
Michael Jordan: 2,514
LeBron James trails Michael Jordan in total steals because the legendary Bulls guard had a career average of 2.3 SPG. James held a career average of 1.6 SPG, and despite playing longer, he could not generate more steals than MJ. Jordan is one of the best defenders ever, so this comes as no surprise.
LeBron James: 1,041
Michael Jordan: 893
LeBron James, as a forward with a large frame, blocked over 1,000 shots in his career. That is an amazing number for a non-big man because ball-handlers are often not known for their shot-blocking ability. Amazingly enough, Michael Jordan was not far off LeBrons total blocks despite playing fewer games and fewer seasons.
LeBron James: 4,782
Michael Jordan: 2,924
Since LeBron James is a pass-first player who handles the ball on almost every possession, it is natural for him to have over 4,000 turnovers. After all, James ranks 1st all-time in turnovers but shares the top-5 with Karl Malone, John Stockton, Russell Westbrook, and Kobe Bryant who were/are ball-dominant stars. Jordan has a lot of turnovers, but LeBron has many more.
LeBron seems to have the edge over Michael Jordan in terms of longevity related accolades including total statistics and more All-Star and All-NBA Teams. But in terms of prime talent and dominance, it is hard to argue LeBron over Jordan.
Michael won more with the Bulls, staying with one team for his career. James had to move a few times to win his titles and often had the deck stacked in his favor. Jordan also seems to have a heavier weight towards his accolades as he has more championships, Finals MVPs, MVPs, scoring titles, and a Defensive Player of the Year.
LeBrons individual statistics will always be greater than Jordans because of his incredible longevity but Mike will find solace in the fact that he always prioritized winning over statistics.
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LeBron James Can Become The GOAT: He Surpassed Michael Jordan In Almost Every Category Except Championships, MVP Awards And Finals MVPs - Fadeaway...
Brings blood biometrics, DNA insights together with activity, heart rate, sleep data from Apple Watch to provide personalized nutrition, lifestyle Action Plan
CAMBRIDGE, Mass., March 29, 2022 /PRNewswire/ -- InsideTracker, the leading truly personalized performance and nutrition system, today announced the availability of Apple Watch integration on its top-performing iOS personalized health app. By bringing together blood biometrics, DNA insights and Apple Watch data including workouts, daily activity, resting heart rate (RHR) and sleep duration, the InsideTracker app delivers sophisticated, science-backed nutrition and lifestyle recommendations never before available in real-time, right to Apple Watch devices.
Key Features
The Deepest Understanding from the Inside OutExercise, RHR and sleep directly affect biomarker levels. With InsideTracker's Apple Watch integration, users can track and analyze blood, fitness and sleep data all in one place, giving a clearer picture of how physiological and biomarker data is interconnected, unlocking new ways to improve health.
More Precise, Personalized RecommendationsThe more data InsideTracker has to work with, the more personalized a user's recommendations become. Each time Apple Watch registers a new, completed activity, InsideTracker progress updates in real-time, fine-tuning the personalized Action Plan.
New, Real-Time ProTipsProTips provide daily, laser-focused nuggets of wisdom that are personalized based on a user's information, backed by science and curated by InsideTracker's registered dietitians. Using data synced from Apple Watch, the integration unlocks hundreds of new ProTips on actions you can take to improve your exercise, RHR and sleep duration.
"InsideTracker is the only system that integrates this level of activity tracking with blood, DNA and lifestyle data, and we're excited to unlock these precision wellness and longevity benefits for 100 million Apple Watch users," said Dr. Gil Blander, co-founder and chief scientific officer, InsideTracker.
To unlock the integration, InsideTracker users with an Apple Watch can download the updated InsideTracker app with Apple Watch integration from the App Store starting today, then log into their InsideTracker account to connect their device.
Apple Watch users without an existing InsideTracker account can visit InsideTracker.com and select the plan that's right for them, provide a blood sample at a local Quest lab, via home kit or upload results from a recent physician-ordered test, then download the app to receive their blood test results, sync with their device and create a science-backed Action Plan to help them reach their personal health and wellness goals.
About InsideTrackerFounded in 2009 by top scientists from acclaimed universities in the fields of aging, genetics and biology, InsideTracker is a truly personalized nutrition and performance system. InsideTracker's mission is to help people add years to their lives and life to their years by optimizing their bodies from the inside out. By analyzing the body's data from blood, DNA and fitness trackers, InsideTracker gives a crystal-clear picture of what's going on inside, along with a science-backed action plan for improving your health and becoming your best self. Read our peer-reviewed papers inScientific Reportsand Current Developments in Nutrition.
Follow InsideTracker on Instagram, Twitterand Facebook.
Media Contact:Heather Hawkins[emailprotected](415) 598-8662
SOURCE InsideTracker
Do you enjoy snacking on dried apricots or dried cranberries? Since dried fruit is basically fruit that is void of water, this means that you can get the same nutritional benefits of "regular fruit" minus the hydration. According to Healthline, dried fruit is really good for you because it contains all kinds of fiber, antioxidants, and micronutrients. That means it might lower your blood pressure levels, balance out your blood sugar, and keep you regular, and, because dried fruit is naturally sweet, it can also help to curb your appetite for processed sugar.
Dried fruits can be good for your breasts because they arehigh in phytoestrogen (plant-based compounds that mimic estrogen), as noted by an article published inPhytotherapy Research. As you age and your body loses estrogen, consuming phytoestrogen foods can potentially boost your estrogen levels so that you look more youthful and radiant breasts included. Dried fruit is one of the sweetest ways to keep your breasts looking younger for longer. Science can totally back this up!
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10 Foods That Are Awesome When It Comes To Breast Health - The List
I take lions mane with a daily microdose of psychedelic, and B6 to switch on the brain and getmore ideas, says writer Catherine Frenette, ofthe effects of her supplements regime. I did it allthrough writing my latest book: I had a short deadline and needed to stay at my desk. It absolutely worked. Without doubt, Im working better.
Tired, unfocused brain in need of a boost? The traditional recourse coffee is, it turns out, very pre-pandemic. A stimulant made for 2019s office-worker world, when we were all just striving to keep up, its ashort-term fix that burns through your adrenal reserves and leaves you, ultimately, depleted. Nowadays, thats not good enough. Enter the latest nootropics cognitive enhancers that will take users up and up, and could support brain function and health in the long term.
Unlike coffee, these new nootropics, or smart drugs, nourish the brain without cashing in on its energy reserves. The brain is the bodys most hungry organ, consuming 20per cent of our energy, so it is vital that it is well fed. Stimulants such as coffee, Adderall or study drug Modafinil operate by robbing Peter to pay Paul: increasing dopamine while simultaneously depleting reserves.
We thinkitsnormal to be tired andforget things. Thats not normal. Weshould be feeling better
There is much debate about which nootropics to take, how to take them and how much to take. In online forums, the nootropic hive mind bandies about options that include amino acids like L-theanine and glutamine, thesalt magnesium threonate, nutrients citicoline and phosphatidylserine, adaptogenic herbs such as rhodiola and Bacopa, or the ubiquitously trending cordyceps.
Everybody wants to know about brain biohacking rightnow, reports Dr Tamsin Lewis, founder of Wellgevity,a personalised preventative healthcare service.Everything starts with the brain. If you can changeyour neurochemistry you movedifferently, you interact differently, the whole filterto your day changes. Lewis, whobegan trying nootropics following a head injury,believes plenty of improvement can be gained, butcounsels: Theresno one-size-fits-all everyones baseline functionis different.Shealso cautions that some supplements are notdosedcorrectly or do not include their ingredients in a bioavailable form its important to look for clarity when it comes to dosages.
Lewis recommends to her patients personalised blends of intravenous ingredients, including B vitamin complex and alpha lipoic acid. She says the latter is agreat enhancer of mitochondrial function, naturally increasing levels of glutathione [an amino acid involvedin cell repair]. It can make your brain feel veryclear for a good few weeks.
Another compelling ingredient is Cognizin, a version ofcholine, which is a compound derived from food, particularly eggs. It promotes the production of phospholipids, which make up the membranes of our neural cells. Studies of Cognizin demonstrate up to a 25percent increase in attention, memory and focus in patients versus a placebo. It is an ingredient available in brain-boosting supplements from Qualia to Mind Lab Pro. JulianLee, CEO of green tech business Binding Solutions, began taking Cognizin as one of the ingredients in the super-supplement Lyma. I have remarkably better energy and focus during theday, he reports. Things have really shifted. Im50 andin very good health and spirits I feel much younger than my age.Mentally, clear as a whistle.
If you can changeyour neurochemistry you movedifferently, you interact differently, the whole filterto your day changes
Over at Matt Roberts Evolution in Mayfair, where longevity doctors, physiotherapists and microdosing and psychedelic experts operate in tandem, a 60-something client is emerging from an intravenous glutathione infusionto treat her brain fog. Glutathione cleans out her cells, explains clinician nurse Michelle Gundry. We thinkitsnormal to be tired andforget things. Thats not normal. Weshould be feeling better. MattRoberts Evolution also hascoffee on the menu, butwitha difference: Mushroom coffee, confirms Roberts, madewith cordyceps to give youthe kick you need withoutthecomedown.
Medicinal mushrooms such as lions mane show someevidence of supporting neural health and cognition. Roberts recommends magnesium threonate for sleep (goodsleep is essential for brain recovery and memory)and the supplement NAD, which is essentially niacin (a vitamin B3 extract), or its more hardcore sister, NMN. NADmay increase human-growth hormone response andtherefore the ability of the bodys cells to regenerate. Watch how you take NMN, though, he says, as it needs to be attached to a fat molecule to be absorbable. Like almost everyone else I spoke to, Roberts cites gut health inthe form of a diet rich in plants and fermented foods asa key element in the quest to improve brain function andadaptability.
Neuroplasticity is also on the mind of Clinique La Prairie, the Swiss health and beauty brand, which declares ita fundamental aspect of healthy ageing. Cognition, says Professor Bogdan Draganski, a neuroscientist at the University Hospital of Lausanne and a member of CLPs scientific committee, is a key target for biohackers or neurohackers, as he calls them. Last year, Clinique La Prairie came out with its own health supplement range, Holistic Health. It has been formulated with the patented nootropic Cognivia, which showed a nine per cent increase in numeric working memory.
Much of the interest in neurohacking is fuelled by the work of key professors at Stanford, Harvard and Yale. Neuroscience professor Andrew Huberman at Stanford School of Medicine is one such guru, as is Harvard professor of genetics David Sinclair. Both publish their work daily on social media and have amassed huge followings. Sinclair believes its possible not onlyfor us tohalt cellular decline but to reverse it. Huberman recommends easy hacks such as 30minutes of sunlight every morning to set the circadian rhythm and put you in control of your nervous system.
Huberman also likes to publish his stack, which is how wellness nerds referto their supplement regime. On a recent podcast he listedhis latest, which included eating foods that are rich inomega-3s and/or supplementing with omega-3s to get 2-3gof the fatty acid EPA per day; phosphatidylserine, alipid-like compound abundant in meat and fish; choline, which helps in modulating brain circuits; and creatine asupplement the fitness-obsessed use to bulk up, but which is good fuel for the brain at least 5g a day, he said.
The science is changing all the time, says James Heagney, gym director of KX health club in South Kensington, where Chelseas most ambitious wellness disciples go forworkouts. We follow the research to choose not justthe nutrients gaining in popularity but those that havescientific backing.
Heagney is currently looking at dopaminergic supplements for focus and concentration, the amino acid tyrosine to improve alertness, and adaptogens like gingko and holy basil. As a 4am riser, and with two young children to wrangle, Heagney is laser-focused on his own stack. Increased performance and cognition is where its at, he says. Brain function is everything in the body.
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The secret to making your brain work better - Financial Times
Even if we have health problems, attitude dominates. Employing these strategies will help you to feel younger than your number
No two 83-year olds are the same. One can run a marathon whereas another may be frail and immobile. Why do some of us appear resilient to ageing while others seem older than our years?
What can we do for ourselves and as a society to ensure that we have fulfilling, happy and fit, long lives? Our research study, The Irish Longitudinal Study on Ageing (TILDA), which followed almost 9,000 adults aged 50 and older, has generated more than400 research papers over the past 12 years. The study covers all aspects of life from sex to food, to physical and brain health, genetics, childhood experience, expectations, friendships, finance and much more to illustrate why and how we age.
Differences in the pace of ageing occur because our biological changes count more than the crowd of candles on our birthday cake. One study showed a difference of 20 years in biological ageing clocks in adults as young as 38. Explanations include changes in metabolic and other cell proteins, often associated with higher inflammation in cells. We have trillions of cells that are dividing and producing new cells all of the time, but imbalances in these processes speed up cell damage and cell death and thus overall ageing.
The good news is that we control 80 per cent of our ageing biology only 20 per cent is controlled by our genes. So it is within our power to modify and improve most of the factors that influence our biological clocks, including inflammation.
Most of us are eager to know more about ageing and health. Yet at the same time many people in midlife tell me they can hardly bear to think about growing old, such is their dread of it.
But, the last lap as one of my patients cheerily calls it can be the most relaxed, worthwhile and contented period of our lives, especially if we prepare for it. The research confirms this. And the earlier we start, the better - although these recommendations are beneficial at any age.
As we know, diet, exercise, stopping smoking and low alcohol intake slow down ageing, but there are also unexpected and fun ways to make us more resilient to the ageing process. Here are eight simple things you can start tomorrow which will make a difference.
Good friends add years to our lives. Examining the association between social bonds and health, I was staggered by the powerful physical effects of friendship.
But why would the strength of our social contacts and social engagement affect mortality? Its been suggested that they lower levels of stress and stress-related hormones, heart disease and inflammation. In fact, regular contact with friends is as good for your heart as stopping smoking or normalising your cholesterol levels.
People who enjoy strong social bonds into their 80s were less likely to succumb to cognitive decline and dementia. The fact that social, mental and physical stimulation through friendships reduce vascular diseases is relevant here too.
High blood pressure, high cholesterol and heart irregularities, such as atrial fibrillation in midlife, are all associated with Alzheimers in later life.
The stress-busting effects of good friendships is another reason these relationships benefit brain health. A higher susceptibility to stress doubles the risk of dementia by triggering chronically high cortisol levels. Frequent social contacts increases the formation of new brain cells, building up capacity or cognitive reserve in the area that converts short-term memory to long-term memory, the area important for concentration, understanding, awareness, thought, languageand consciousness, and the area governing our sense of smell.
So even if people have abnormal proteins in their brain cells (dementia pathology), they dont show signs of the disease: their reserve capacity built through social contacts enables normal function. We laugh more when were with friends laughter bonds us with others.
Healthy children laugh as much as 400 times per day but older adults tend to laugh only 15 times per day. Yet laughter keeps us young.
As well as boosting endorphin levels, laughter is a form of muscular exercise, good for circulation and digestion. A good belly laugh provides a workout for the diaphragm, abs, and shoulders plus the immune system and heart.
Laughter is beneficial at a chemical level because it lowers the stress hormones cortisol and adrenaline. And low cortisol stabilises blood sugars and insulin, regulates blood pressure, and reduces inflammation.
Even when we only anticipate having a laugh, our positive hormonal system kicks in and risesas much as 87 per cent. The same expectation mutes stress hormones by up to 70 per cent. So, next time you search for your favourite Father Ted episode, know that you are building up your health stores and resources. (What would Dougal have to say about that, Ted?)
Laughter also increases endorphins chemicals produced naturally by the nervous system to cope with pain or stress, the feel-good chemicals. It raises serotonin and dopamine, which play a critical role in sensations of pleasure, motivation, memory and reward. They make us feel calm, poised, confident and relaxed.
When serotonin and dopamine levels are low, we are nervous, irritable and stressed. Endorphins also play a role in the immune response and in killer T cells, which help to fight infections. Given that immune function declines with age, boosting endorphins is particularly beneficial in older persons.
Stress is ageing. Its biological impacts affect our nervous system, hormones, immune system and metabolic systems. Persistent stress can lead to obesity, diabetes, high blood pressure, a fast heart rate, heart attacks and strokes. A visible measure of how acute stress can age us is that it can turn hair grey overnight. Simple techniques can provide a buffer against stress:
One is regular switch-off periods a time each day when phone and internet are turned off. Let friends and colleagues know you are doing this so that you are not stressed when the phone is off.
Share your worries with a friend. Research shows that a problem shared is a problem halved and, indeed, reduces stress by lowering cortisol.
Take up gardening. A recent paper analysed 22 studies on gardening and health. The host of positive effects included reductions in depression, anxiety, and BMI, plus a rise in life satisfaction and quality of life.
Walks in nature, forests and green spaces have a notably calming effect: stress levels fall and creativity increases dramatically.
Spend one minute doing controlled breathing a few times a day.
Do meditation for five minutes each morning. Brain scans show that meditation preserves the brains main structural tissues. It also potentially suppresses processes that contribute to brain ageing.
Dispositional mindfulness focusing attention to present thoughts and feelings has physical, psychologicaland cognitive benefits (its the opposite of letting our mind wander and fretting about the future).
Falls are the main cause of accidental deaths and of fractures as we get older. Almost half of people who break a hip never regain their previous independence or vitality. Balance starts to decline after age 40 and is one of the commonest reasons for falls.
So work on balance. Agood start is to stand on one leg while brushing your teeth or at the kitchen sink. Can you stand on one leg for 30 seconds eyes open and 10 seconds eyes closed? That should be your target. Pilates also improves balance and core strength.
Cold water immersion provides a stimulus to our physiological systems, which is related to the phenomenon of hormesis, whereby small amounts of a harmful or painful agent are actually good for us and for the ageing process.
Exposure of the skin to cold water increases release of important nerve signals and chemicals. Chemicals such as noradrenaline, endorphins and opioids are increased and boost performance of cells in both the brain and body that regulate a host of functions such as heart rate, blood pressure, blood flow to muscles, power of contraction of skeletal muscles and release of energy.
Neurotransmission in brain areas that control emotions including depression, concentration, memory and alertness are improved. Because responsiveness to noradrenaline declines with age, any stimulus that enhances its activity is important to ageing physiology.
Hormesis also boosts immune responses and reduces frequency of chest infections. Start at 20 seconds after completing ablutions in warm water and gradually work up to two minutes. Youll eventually find it is addictive. Try it and see.
Until recently, humans were predominantly exposed to, and their lives and evolution depended on, yellow light (wavelength 570-590nm). Blue light (wavelength 450-495nm) exposure was limited to a few hours in winter.
However, over the past few decades blue light has been used more and more, emitting from devices such as televisions, phones and computers. Blue light suppresses melatonin, which is our bodies natural sleeping tablet, thereby causing sleep disorders and insomnia.
Melatonin declines with ageing. So to help with sleep, which plays a major role in the ageing process, and during which our memory stores are refreshed, avoid blue light for at least one hour before bed. Taking a hot bath will also help to enhance sleep and fill the time that you would normally use looking at a device.
As well as improving balance and flexibility at a cellular level, yoga reduces inflammation and thereby slows biological ageing. Several studies show that yoga increases the length of telomeres the protective coverings at the end of chromosomes which stop chromosomal damage. With ageing, telomeres shorten, chromosomes are damaged, cells decay and die.
Fascinating animal studies show that if two groups of animals are fed the same amount of food within 24 hours, but one group just gets all the food within eight hours and the other over 24 hours, the latter become obese and the former do not.
Much research supports the fact that metabolic proteins and hormones are some of the most important in respect of cell ageing and that restricting foods and periods of fasting switch on protective cell mechanisms beneficial for longevity. Grazing throughout the day is bad news. So try to stick to eating within an eight-hour window and no snacks.
The science shows that you are as young as you feel be optimistic about your biological age it will affect how you age. Our studies show that people who feel their chronological age are more likely to develop physical frailty and poor brain health in subsequent years than those who claim to feel younger than they are.
Older adults with negative perceptions about ageing are likely to die seven and a halfyears earlier, mostly because of higher rates of heart disease. A positive attitude towards getting older changes cell chemicals beneficially, possibly by reducing inflammation (low-grade chronic inflammation, from impaired immune responses, is associated with accelerated ageing and many age-related conditions).
Even if we have health problems, attitude dominates. Employing the strategies above will help you to feel younger than your number.
Age Proof: The New Science of Living a Longer and Healthier Life by Prof Rose Anne Kenny is published by Lagom. ProfKenny holds the chair of medical gerontology at Trinity College Dublin and is the founder and principal investigator of The Irish Longitudinal Study on Ageing (TILDA), Irelands flagship research project in ageing
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Irish study finds eight novel ways to live longer (it's not all diet and genes) - The Irish Times