Kaiser Permanente researcher and colleagues reports new findings from long-term study in PLOS Medicine
BySue Rochman
Ten years ago, Kaiser Permanente Division of Research research scientist Erica P. Gunderson, PhD, MS, MPH, became the Principal Investigator on one of the worlds largest and most diverse prospective studies to look at future health outcomes in women who developed gestational diabetes (diabetes diagnosed for the first time during pregnancy) .
Erica P. Gunderson, PhD, MS, MPH, research scientist, Kaiser Permanente Division of Research.
New findings from the Study of Women, Infant Feeding and Type 2 Diabetes After GDM Pregnancy (SWIFT) were published on May 20 in PLOS Medicine. The new research, Amino acid and lipid metabolism in post-gestational diabetes and progression to type 2 diabetes: A metabolic profiling study, conducted by Gunderson and her long-time collaborators at the University of Toronto, exemplifies what can be learned from a transdisciplinary approach that merges biochemistry and clinical epidemiologic research. The findings have also brought Gunderson a step closer to achieving one of the SWIFT studys primary goals: developing a new blood test for early prediction of women with gestational diabetes who are at greatest risk of developing type 2 diabetes in the future. Gunderson talked about reaching the 10-year anniversary of the SWIFT study, the most recent findings, and where her research on maternal health is headed
Q: What makes the SWIFT study unique?
Gunderson: What makes the SWIFT study different from many other Kaiser Permanente research studies is that it doesnt rely solely on electronic medical records. Our study team recruited 1,033 women with gestational diabetes during pregnancy for the SWIFT study and conducted research oral glucose tolerance tests and assessments from 2 months after delivery and beyond to build a biobank of blood samples and research databases. The SWIFT participants are an ethnically and racially diverse group of women who were diagnosed with gestational diabetes during a pregnancy between 2008 and 2011. Each woman consented to 3 in-person research visits, starting 6 to 9 weeks after giving birth and up to two years later, where we measured body weight, height, and waist circumference, and asked questions about breastfeeding and other lifestyle factors during the first year after delivery. At each study visit, each woman was also given a research oral glucose tolerance test. As a result, the blood samples we have collected over the past 10 years provide a rare resource to measure biomarkers preceding the development of type 2 diabetes in the SWIFT study participants.
Q: What were the main findings from your new PLOS Medicine study?
Gunderson: Right now, a 2-hour oral glucose tolerance test that requires a woman to fast for 8-14 hours is used to test for diabetes after pregnancy. Our goal for the SWIFT 10-year followup study is to develop an alternative blood test. The new study published in PLOS Medicine added 1,000 more metabolites to our previous analysis. This helped identify an expanded group of metabolites that can predict with over 80% accuracy which women with gestational diabetes are at highest risk of progressing to type 2 diabetes. A blood test that looks at levels of these metabolites would allow obstetricians and primary care providers to identify the women most at risk for type 2 diabetes and advise them about changes in behavior to prevent future diabetes, such as breastfeeding, getting enough sleep, and healthful eating habits to avoid weight gain.
Q: What have you learned from following these women for 10 years?
Gunderson: There are other studies that have looked at progression to diabetes after pregnancy among women with gestational diabetes. But our study is the largest prospective study of women with gestational diabetes in which all participants were given standardized oral glucose tolerance tests from early postpartum and then tested for diabetes annually for up to 2 years. Weve now seen about 20% of these women have developed diabetes within 8 to 10 years after pregnancy. In the general population, among women of this age, about 2% would would have progressed to diabetes within 10 years of giving birth. That means for the women with gestational diabetes, their risk is about 7 to 10-fold higher. My previously published studies have shown that women who breastfed for 5 to 6 months or more had half the risk of developing type 2 diabetes after gestational diabetes, independent of other factors, and that their infants had less rapid weight gain growth. Our ongoing studies will also provide insights into how the severity of gestational diabetes may affect a womans future risk for cardiovascular risk factors and outcomes.
Q: What will happen next?
Gunderson: Our research staff was ready to begin contacting the women in the SWIFT study for their 10-year follow-up visits to administer a fourth research blood test for type 2 diabetes when the COVID-19 pandemic hit. We will pick up where we left off, as soon as we can. The information we glean from the 10-year study research visits will bring us even closer to our goal of developing this test. It will also help us to identify metabolic differences that are associated with race and ethnicity that this test will need to take into account. Many thanks to all of the women who have stayed in the SWIFT research study for 10 years. Their decision to be part of this study and their continued participation will help many women in the future.
Funding for the new study in PLOS Medicine was supported by research grants from The National Institute of Child Health and Human Development (Gunderson, PI); The National Institute of Digestive, Diabetes and Kidney Disease (Gunderson, PI); Canadian Institutes of Health Research; and Janssen Pharmaceuticals Companies.
Coauthors of the new PLOS Medicine study include Mi Lai, Ying Liu, Anne Wu, Brian J. Cox, Feihan F. Dai, Hannes L. Rst, and Michael Wheeler of the University of Toronto and Gabriele V. Ronnett of Janssen Research & Development.
View original post here:
Blood test to identify risk for diabetes after pregnancy in women with gestational diabetes now one step closer - Kaiser Permanente Division of...
- 1 woman thought she was destined for diabetes. This 1 realization helped her lose 70 pounds - Yahoo! Voices - March 29th, 2024
- Franciscan Health offering diabetes education at local churches - The Times of Northwest Indiana - March 29th, 2024
- For diabetes patients, needle-free insulin injections are on the way - ScienceBlog.com - March 29th, 2024
- Las Vegas nonprofit hosting health workshop specifically aimed at local Latinos - KTNV 13 Action News Las Vegas - March 29th, 2024
- How Often Do You Really Need to Check Your Blood Sugar Levels? - WSJ - The Wall Street Journal - March 29th, 2024
- Unintended Effects of Caps on Insulin Out-of-Pocket Costs - Managed Healthcare Executive - March 29th, 2024
- Study: Pompe treatment Nexviazyme isn't linked to new or worsening... - Pompe Disease News - March 29th, 2024
- A Smoker With New-Onset Pain in Both Feet - Medscape Reference - March 29th, 2024
- Pre-diabetes leads to Type 2 diabetes; Here's how to prevent and reverse it - WXII12 Winston-Salem - March 29th, 2024
- 'From Interpretation to Action': Using CGM to Manage T2D - Medscape - March 29th, 2024
- March: diabetes-kidney | News and features - University of Bristol - March 29th, 2024
- Health centers attempt to prevent diabetes - WTVM - March 29th, 2024
- Beyond Meat Unveils New and Expanded Line of Beyond Crumbles, Now Certified by the American Heart ... - Yahoo Finance - March 29th, 2024
- Beyond Meat Launches Revamped Plant-Based Crumbles, Earning American Heart and Diabetes Association ... - vegconomist - the vegan business magazine - March 29th, 2024
- Ypsomed hands off insulin pen needle business to focus on smart pump, autoinjector development - Fierce Biotech - March 29th, 2024
- Take the online diabetes test that could help save your life - NBC Connecticut - March 29th, 2024
- Study evaluates the use of tirzepatide in overweight/obese adults with type 1 diabetes - News-Medical.Net - March 29th, 2024
- Risk prediction using genes and gut bacteria can improve early detection of diseases like type 2 diabetes - Medical Xpress - March 29th, 2024
- On a Healthy Vegan Diet, I've Healed My Liver, Reversed Type 2 Diabetes, and Lost 35 Pounds - Forks Over Knives - March 29th, 2024
- Study Links Diet, Diabetes, and Alzheimers - Neuroscience News - March 29th, 2024
- Novo Nordisk Isn't in The "Magnificent Seven," but Here's Why I Think It Should Be - Yahoo Finance - March 18th, 2024
- Doctor warns of strange telltale sign of diabetes which can appear on the legs - The Mirror - March 18th, 2024
- Unraveling the complexities of muscle repair in diabetes: A call for targeted research and therapies - News-Medical.Net - March 18th, 2024
- Popular diabetes and weight loss drugs often hard to get for people who need them - NBC News - March 18th, 2024
- Your Health Matters: The ABCs of diabetes - The Globe | News, weather, sports from Worthington, Minnesota - The Globe - March 18th, 2024
- The Link Between Pancreatic Cancer and Diabetes - Cedars-Sinai - March 18th, 2024
- Nikita Kuzmin diabetes: what was he holding in the CBB house? - Cosmopolitan UK - March 18th, 2024
- FDA Approves Rezdiffra, the First Drug for Diabetes-Related Liver Disease - diaTribe Foundation - March 18th, 2024
- He took up running rather than take diabetes medication. It worked - South China Morning Post - March 18th, 2024
- Can Eating Yogurt Really Reduce Your Risk of Diabetes? - Health.com - March 18th, 2024
- Even short periods of diabetes remission are linked to lower risk of heart attack and stroke - The BMJ - March 18th, 2024
- Kidney stone risk factors and how type 2 diabetes medication may help - WECT - March 18th, 2024
- 'Making the Invisible Visible': CGMs Offer Insights for T2D - Medscape - March 18th, 2024
- Novo Nordisk Discontinues Insulin Medication After Cutting Its Price - The American Prospect - March 18th, 2024
- Infographic: Where GLP-1s Work Now -- and What's Coming - Medscape - March 18th, 2024
- Intermountain Health Experts Say Education Key to Prevention of Type 2 Diabetes | PRUnderground - PR Underground - March 18th, 2024
- International body recommends more sensitive test to indicate risk of developing diabetes - The Hindu - March 18th, 2024
- The importance of knowing your A1C level - KSAT San Antonio - March 18th, 2024
- Tandem Diabetes Care's t:slim X2 Insulin Pump is the First Automated Insulin Delivery System to Integrate with ... - Business Wire - January 9th, 2024
- Diffuse Alveolar Hemorrhage Occurring Suddenly in a Diabetic Patient With Asthma Exacerbation - Cureus - January 9th, 2024
- Virginia Tech researchers find drugs used to treat Type 2 diabetes reduce alcohol cravings - WRIC ABC 8News - January 9th, 2024
- FDA looking into reports of hair loss, suicidal thoughts in people using popular drugs for diabetes and weight loss - CNN - January 9th, 2024
- Glycemic control and cardiovascular outcomes in patients with diabetes and coronary artery disease according to ... - Cardiovascular Diabetology - January 9th, 2024
- Insulin price cap: More Americans will now pay no more than $35 - USA TODAY - January 9th, 2024
- Eli Lilly cracks down on the use of weight loss drugs Mounjaro and Zepbound for cosmetic reasons instead of for diabetes and obesity - Fortune - January 9th, 2024
- No Increased Risk of Suicidal Ideation With GLP-1 Drugs - Medpage Today - January 9th, 2024
- Ask the Doctors | New research being conducted to treat diabetes - Eureka Times-Standard - January 9th, 2024
- Salivary Chloride Intracellular Channel 1 (CLIC1) as a Hub of Gene-Gene Interactome of Periodontitis With Diabetes ... - Cureus - January 9th, 2024
- Why Omada's CEO Thinks Amazon Selected His Startup as the 1st Partner for Its New Program - MedCity News - January 9th, 2024
- Researchers find drugs used to treat type 2 diabetes and obesity reduce alcohol cravings - Medical Xpress - January 9th, 2024
- Randomized open-label trial of semaglutide and dapagliflozin in patients with type 2 diabetes of different ... - Nature.com - January 9th, 2024
- CV Safety Profile of TheracosBio's BRENZAVVY (bexagliflozin) Confirmed in Research Published in Diabetes ... - Business Wire - January 9th, 2024
- 6 "Bad" Fruits You Should Be Eating When You Have Diabetes, According to Dietitians - EatingWell - January 9th, 2024
- Children of Women with Type 1 Diabetes Have Increased Heart Defect Risk - Inside Precision Medicine - January 9th, 2024
- Transforming Corporate Health: Fitterfly's Success in Tackling Diabetes and Weight Issues - Business Standard - January 9th, 2024
- Ozempic and weight loss | News and views - Diabetes UK - January 9th, 2024
- Drugs used to treat Type 2 diabetes reduce alcohol cravings - ScienceBlog.com - January 9th, 2024
- People taking Wegovy and Ozempic have lower risk of suicidal thoughts vs. older drugs, study finds - ABC News - January 9th, 2024
- For Those With Diabetes On Medicare Part D, Insulin Is $35...If Its Covered - Forbes - October 27th, 2023
- Biologist Douglas Melton: I was studying frogs until my son was diagnosed with diabetes then I started looking for a cure - EL PAS USA - October 27th, 2023
- Diabetes and Hearing Loss with Concept by Iowa Hearing | Paid Content - Local 5 - weareiowa.com - May 9th, 2023
- COUNTY COLUMN: Learn to Live well with diabetes at The Well - Norman Transcript - May 1st, 2023
- Want to Cut Type 2 Diabetes Risk? This High-fat Food Can Be the Answer, According to New Study - Revyuh - May 1st, 2023
- Diabetes: What It Is, Causes, Symptoms, Treatment & Types - March 13th, 2023
- A number of healthtech startups claim they can reverse Type 2 diabetes. But caveats apply, caution doctors - Economic Times - March 13th, 2023
- Tampa doctor who lost brother to diabetes calls insulin price cut a 'game changer' - ABC Action News Tampa Bay - March 5th, 2023
- New study suggest people previously infected with COVID-19 could have increased risk for diabetes - CBS Los Angeles - February 16th, 2023
- Diabetes Symptoms, Causes, & Treatment | ADA - October 15th, 2022
- A nutritionist with type 1 diabetes shares the top 5 'food swaps' she eats to manage her blood sugar - CNBC - October 15th, 2022
- Diabetes and the gut: How a bacterial protein may impact insulin - Medical News Today - October 15th, 2022
- Milton teen involved in launch of diabetes support program - Milton Daily Standard - October 15th, 2022
- Providers Now Have Free Access to Latest Diabetes Technology in One Place - PR Newswire - October 15th, 2022
- 5 Modifiable Factors in Women with History of Gestational Diabetes Mellitus That Can Reduce the Risk of T2D - Pharmacy Times - October 15th, 2022
- BCMH the stoy of Diabetes and Determination - 921News - October 15th, 2022
- Can skipping a meal lead to diabetes and fat around abdomen? - The Indian Express - October 15th, 2022
- Type 2 Diabetes Drugs Market Research Report by Drug, Application, Distribution, Region - Global Forecast to 2027 - Cumulative Impact of COVID-19 -... - October 15th, 2022
- Diabetes: Symptoms, risks, and prevention - Wilmington News Journal, OH - July 17th, 2022
- Diabetes symptoms: The sign of nerve damage that often strikes at night - severe - Express - July 17th, 2022
- Local Teen Brings Smiles and Health Kits to Kids with Diabetes - River Journal Staff - July 17th, 2022
- Type 3 diabetes: symptoms, causes and treatments - Livescience.com - July 17th, 2022