StemCell Therapy

5 November 2019

Singapore A*STARs Institute of Bioengineering and Nanotechnology (IBN) has teamed up with the Singapore Institute of Advanced Medicine Holdings Pte Ltd (SIAMH) to explore how to better tackle nasopharyngeal carcinoma (NPC), a type of head and neck cancer, through targeted proton therapy.

The two parties are collaborating through an agreement to evaluate and optimise proton therapy for NPC with the use of patient-derived xenografts as well as in vitro 3D organoid models developed at A*STARs IBN, specifically for the treatment of recurrent and radioresistant NPC. The parties will also perform research on designing and establishing novel nano-radiotheranostic agents.

NPC that is detected early is often treated by radiotherapy, concurrently with chemotherapy. However, NPC presents a unique treatment challenge for radiation oncologists due to the proximity of cancer tissues to several critical organs and tissues such as the brain, the spinal cord, the salivary gland, and the optical nerves. Any damage to these adjacent structures could severely impair the quality of life of patients following the treatment.

Figure-1---The-treatment-room-of-a-proton-facility - Image-Credit-SIAMH

Proton therapy could help solve some of these existing treatment challenges. It is a newer mode of radiation therapy that allows proton beams to more precisely irradiate the tumour compared to the x-rays used in conventional radiotherapy. This results in sparing damage to nearby healthy tissues and organs, and potentially less treatment-related side effects for patients to enjoy improved quality of life.

We are excited to partner with SIAMH to explore ways of optimising proton therapy for treating NPC, through leveraging IBNs expertise in developing tumour models and organoids for disease modelling and therapeutic optimisation, said Dr. Lucky Sasidharan, Postdoctoral Fellow at A*STARs IBN.

This collaboration offers a great opportunity to mutually apply our technologies and expertise in an innovative fashion for the benefit of cancer patients, added Dr. Lim Chwee Ming, Adjunct Clinician Scientist at A*STARs IBN.

Figure-2---Components-of-the-proton-facility-of-SIAMH - Image-Credit-SIAMH

Dr. Djeng Shih Kien, Chairman and CEO of SIAMH said, We are very happy to be able to collaborate with A*STAR's IBN and develop a focus group interested in treating Asian cancers like NPC. Although NPC is rare in the Western world, it is common in Asia. There are 300 new cases a year in Singapore alone. It is the 3rd most common cancer in Malaysia, after colorectal and lung cancer.

Dr. Djeng added: Singapore is a small country with limited resources and talent pool. SIAMH's first collaboration with IBN is our attempt to bring together leaders of IBN and the private sector in Singapore as well as domestic and international experts to maximise talent usage. Proton Therapy will be available in Singapore by early 2020. It would significantly reduce side effects due to its characteristic tumour targeting abilities which would be very advantageous in sparing critical structures in the case of NPC patients.

Recently, the group also presented their work at the Australia and New Zealand Head and Neck Cancer Societys Annual Scientific Meeting held at Adelaide[1][1].

NPC is the 9th most common cancer and 7th most frequent cause of cancer related deaths amongst males in Singapore.2 It is often associated with an Epstein-Barr virus (EBV) infection of the white blood cells and nasal lining at the back of the nose. One of the most common signs of newly-diagnosed NPC is the appearance of one or more lumps in the nose or on the neck.

About the Institute of Bioengineering and Nanotechnology

The Institute of Bioengineering and Nanotechnology (IBN) is the worlds first bioengineering and nanotechnology research institute. Established in 2003, IBNs mission is to conduct multidisciplinary research across science, engineering, and medicine for breakthroughs to improve healthcare and quality of life. IBNs research activities are focused on Nanomedicine and Biomaterials, Synthetic Xenobiology and Biosystems, Tissue and Organoid Models, and Green and Safe Biomaterials. The Institute has published over 1,320 papers in leading scientific journals, filed over 660 active patents and patent applications on its inventions, and established 12 spin-off companies. For more information on IBN, please visit http://www.a-star.edu.sg/ibn.

About the Agency for Science, Technology and Research (A*STAR)

The Agency for Science, Technology and Research (A*STAR) is Singapore's lead public sector agency that spearheads economic oriented research to advance scientific discovery and develop innovative technology. Through open innovation, we collaborate with our partners in both the public and private sectors to benefit society.

As a Science and Technology Organisation, A*STAR bridges the gap between academia and industry. Our research creates economic growth and jobs for Singapore, and enhances lives by contributing to societal benefits such as improving outcomes in healthcare, urban living, and sustainability.

We play a key role in nurturing and developing a diversity of talent and leaders in our Agency and research entities, the wider research community and industry. A*STARs R&D activities span biomedical sciences and physical sciences and engineering, with research entities primarily located in Biopolis and Fusionopolis. For ongoing news, visit http://www.a-star.edu.sg.

About the Singapore Institute of Advanced Medicine Holdings Pte Ltd

The Proton Therapy Pte Ltd, a subsidiary of the Singapore Institute of Advanced Medicine Holdings Pte Ltd (SIAMH), will provide proton beam therapy treatment in Singapore. It is part of a new oncology center that is located at the Biopolis, Singapore. The new oncology center will include a comprehensive diagnostic center providing both imaging and laboratory services using advance medical technologies. Its training facility, the Advanced Medicine Training Centre, will provide the necessary training to the specialists in this part of the world. For more information, search proton.sg.

See more here:
Taking Better Aim at Nasopharyngeal Carcinoma Using Proton Therapy - BioSpace

Over billions of years nature has perfected ingenious ways for biological cells to move around their environment and harmlessly transport packages of chemicals between one another.

Now scientists are mimicking some of these processes to create new nanomachines that could eventually help treat diseases like leukaemia and other cancers.

One approach takes its inspiration from the story of the siege of Troy, when the Greeks hid their warriors inside a giant wooden horse in order to get inside the city.

Professor Valentina Cauda, a chemical engineer at the Politecnico di Torino in Italy, is leading a project to create nano-sized crystals of zinc oxide that can kill cancer cells from the inside. By themselves the crystals, which are around 20 nanometres in size about 6,000 times smaller than the width of a human hair can be toxic to healthy cells in the body and can trigger an immune reaction that prevents them from reaching the tumour.

But Prof. Cauda and her colleagues on the TrojaNanoHorse project have developed a shell around the crystals so they can slip them past the bodys defences and inside cancer cells.

The idea is to elude the immune system and to elude the barrier of the cell membrane thanks to the biomimetic shell, says Prof. Cauda. In the Trojan horse analogy, the (cancer) cell can be the city of Troy.

Fatty

The tiny shells, which are between 100-200nm or 1,000 times smaller than a human hair, are made from fatty molecules called lipids that form the outer membrane of almost all living cells. In nature, small droplets made from these lipids known as vesicles constantly bud off from the surface of our cells with chemical messages or unwanted materials inside so they can be carried safely to other parts of the body.

Prof. Cauda and her team have tried to copy this by coating their nanocrystals in vesicles produced by cells grown in the lab so they too can pass harmlessly through the body. The surface of the vesicles can also be studded with antibodies against specific cancer cells, helping them to hone in on only the cells they want to kill.

Once a vesicle finds a cancer cell, its antibodies will bind to the surface, allowing the lipids to merge with the cell and releasing the toxic nanocrystal inside. And by growing nanoshells from cells taken from a patients own body, Prof. Cauda believes it will be possible to create personalised treatments that can evade the immune system while still killing cancer cells.

The team have already tested the nanoshell approach against leukaemia cells and cervical cancer in the laboratory. While they hope to be able to perform human trials in the future, Prof. Cauda warned it could still be many years before they reach that stage.

Benefits

If successful, however, this nanomedicine approach could bring benefits compared to traditional chemotherapy treatments by only targeting tumour cells, leaving healthy tissue unaffected and so reducing side-effects.

The nanomedicine approach could offer a site-selective and personalised treatment for the patient, said Prof. Cauda.

In the Trojan horse analogy, the (cancer) cell can be the city of Troy.

Professor Valentina Cauda, Politecnico di Torino, Italy

This approach, however, still largely relies upon the nanoshells chancing upon the cancer cells as they circulate in the patients bloodstream so they can attach to them.

Another team of researchers are working on nano- and micro-machines that might actively be able to improve this by carrying treatments to the site in the body where they are needed.

Dr Larisa Florea, a materials scientist at Trinity College Dublin in Ireland, is leading a project called ChemLife to create miniature vehicles that can move by themselves in a liquid.

Chemotaxis

The team is attempting to emulate a form of movement known as chemotaxis, which is employed by some basic microorganisms and enables them to move through solutions from low salinity to high salinity, or from acidic to alkaline solutions, for example.

Other research teams in the US have previously shown that man-made droplets can be very precisely navigated through complex mazes with this approach. Dr Florea and her colleagues have sought to extend this by using light to control the movement of droplets.

They have created vesicle-like droplets that pair light sensitive molecules with compounds known as surfactants. Surfactants are commonly found in detergents but are also commonly found in many biological systems.

When exposed to light, the photosensitive molecules react by changing their shape, altering the surface tension on each side of the droplet. This causes the molecules in the droplet to flow from one side to the other, driving it forward, a little like the tread of a tank.

The team have shown they can accurately steer droplets through three dimensional spaces and reach speeds of up to 10.4mm per second (0.02mph).

By adding a photoactive material to a droplet, scientists have been able to control its movement in three dimensions through water using light. Video credit -Yang Xiao (author) and co-authors: Sara Zarghami, Klaudia Wagner, Pawel Wagner, Keith C. Gordon, Larisa Florea, Dermot Diamond, David L. Officer.

If you compare the speed of the movement to the size of these microdroplets, they are faster, pound for pound, than some of the best swimmers in the world, said Dr Florea.

They have also been able to demonstrate that their droplet-shaped vehicles can carry cargo, delivering it to other droplets to trigger a chemical reaction. It raises hopes that similar methods could be used to deliver drugs or other sorts of treatments to specific cells in the body.

While it may be difficult to use light to navigate a drug-carrying droplet through the body, Dr Florea and her colleagues have also explored using mild electrical currents.

Propel

The team have also been developing more complex micromachines that can swim or crawl through liquids like tiny bacteria. Using highly precise 3D printing techniques, they have been able to create hydrogel structures around a few micrometres in size that can contract and expand to propel a structure forward.

We have been making tiny flower-like structures, for example, that can open and close in response to different stimuli, she said. For example it might open at a certain pH and close at another.

This happens because the hydrogels expand by absorbing water and contract by expelling it according to the pH of the surrounding solution.Dr Florea said they hope to also control the movement of hydrogels with changes in temperature or pulses of light.

The ChemLife team are using these hydrogels to create structures with tiny rotating flagella the tiny tail-like appendages that some bacteria use to propel themselves. They are also creating worm-like structures from the same kind of hydrogels that can crawl along surfaces or through liquids.

The ultimate goal is to have these micro-vehicles perform actions like drug delivery or (chemical) sensing, said Dr Florea. But we have to be realistic that this might not be achieved in the near future as the body is a very difficult environment.

The tiny moving structures could also find uses in other ways too. These include delivering chemicals to better improve industrial reactions or creating soft micro-grippers that could be remotely activated to handle delicate components like cells without damaging them.

When you look at what nature can achieve, the opportunities are endless, added Dr Florea.

The research in this article was funded by the EUs European Research Council. If you liked this article, please consider sharing it on social media.

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Nanovehicles that mimic nature could deliver treatments of the future - Horizon magazine

Nanomedicine Market report has been structured after a thorough study of various key market segments like market size, latest trends, market threats and key drivers which drives the market. This market study report has been prepared with the use of in-depth qualitative analysis of the global market. The report displays a fresh market research study that explores several significant facets related to Nanomedicine Market covering industry environment, segmentation analysis, and competitive landscape. This global market research report is a proven source to gain valuable market insights and take better decisions about the important business strategies.

Industry Analysis:

Global nanomedicine market is registering a healthy CAGR of 15.50% in the forecast period of 2019-2026. This rise in the market value can be attributed to increasing number of applications and wide acceptance of the product globally. There is a significant rise in the number of researches done in this field which accelerate growth of nanomedicine market globally.

Top Dominating Competitors are: Abbott, Invitae Corporation, General Electric Company, Leadiant Biosciences, Inc., Johnson & Johnson Services, Inc., Mallinckrodt, Merck Sharp & Dohme Corp., NanoSphere Health Sciences, Inc., Pfizer Inc., CELGENE CORPORATION, Teva Pharmaceutical Industries Ltd., Gilead Sciences, Inc., Amgen Inc., Bristol-Myers Squibb Company, AbbVie Inc., Novartis AG, F. Hoffmann-La Roche Ltd., Luminex Corporation, Eli Lilly and Company, Nanobiotix, Sanofi, UCB S.A., Ablynx among others.

Nanomedicine Market Report incorporates the precisely contemplated and surveyed information related to the Nanomedicine Market by utilizing various explanatory tools and techniques. The explanatory devices, for example, PEST analysis, Porters five Forces examination, SWOT investigation, speculation return examination and feasibility analysis have been utilized to break down complex Nanomedicine Market data.

Market Drivers and Restraint:

Table of Contents:

Chapter 1 Industry Overview:

Chapter 2 Premium Insights

Chapter 3 Production Market Analysis:

Chapter 4 Major Market Classification:

Chapter 5 Major Application Analysis:

Chapter 6 Industry Chain Analysis:

Chapter 7 Major Manufacturers Analysis:

Chapter 8 New Project Investment Feasibility Analysis:

Chapter 9 Market Driving Factors:

Explore Full Report with Detailed TOC Here at https://www.databridgemarketresearch.com/toc/?dbmr=global-nanomedicine-market

Geographical landscape

Have look on the Premium Insights of the Report

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Nanomedicine Market Analysis by Growth, Segmentation, Performance, Competitive Strategies with Top Players Pfizer Inc., CELGENE CORPORATION, Teva...

Japanese researchers have developed a machine learning model that allows scientists to reconstruct the neuronal circuitry of the brain by measuring signals from the neurons themselves.

According to experts in the field, the brain is considered to be one of the most complex systems in existence. While significant headway has been made to understand how the brain works, researchers tend to generate more questions than answers about this entity.

However, the creators of the machine learning model - a team from Kyoto University - believe it has the potential to explain the difference in neuronal computation in different brain regions more clearly.

To comprehend the brain, neurologists must look at the neurons that construct it. Our entire world of perception runs across these billions of cells in our head and that is compounded by the exponentially larger number of connections known as synapses between them. This, therefore, makes the path to our understanding of the brain a challenge.

Shigeru Shinomoto from Kyoto Universitys School of Science, who led the project, explained that although it is possible to record the activity of individual neurons in the brain and that number has increased dramatically over the last decade it is still a challenge to map out how each of these cells connects to each other.

It has been suggested that neuronal connectivity can be estimated by analysing the correlation between neuronal signals, Shinomoto explained. But getting accurate inference was difficult because of the amount of external noise coming from other neurons.

As part of their study, the team constructed an analytical method that takes the signal spikes from individual neurons and estimates the inter-neuronal connections from them.

To eliminate data-contaminating 'noise', the researchers applied a generalised linear model (GLM), a basic model in machine learning, to a cross correlogram (an image of correlation statistics) that records the firing correlation between neurons.

We called our analysis GLMCC and it estimated the strength of nerve connections in units of synaptic membrane potential, said Ryota Kobayashi from the National Institute of Informatics (NII) based in Tokyo.

To confirm if our data reflected real-world connectivity, we evaluated its accuracy through a simulation of a large network of neurons. We confirmed that the new model has an accuracy of 97 per cent, much higher than any previous method.

A brain circuit diagram can be obtained by applying the GLMCC (Generalised Linear Model for Cross Correlation) programme

Image credit: Kyoto University/Shinomoto Lab

The model was then applied to experimental data of neuron activity in the hippocampus (a brain structure embedded deep in the temporal lobe of each cerebral cortex) of rats. When analysed, the team found the estimated connections matched the results inferred with other physiological cues.

A 'ready-to-use' version of the deep learning model is available online and the team hopes it will be utilised by neuroscientists around the world.

Shinomoto concluded: As we advance in technology, the amount of neurological data we collect will increase. Our new analytical model will be vital in processing that information and will lead us to better understand how our brains process the world around us.

The paper, Reconstructing Neuronal Circuitry from Parallel Spike Trains,waspublished in the journalNature Communications.

In April, researchers from UC Berkeley and the US Institute for Molecular Manufacturing (iMM) predicted that exponential progress in nanotechnology, nanomedicine, artificial intelligence and computation will lead to the development of a human brain/cloud interface and will give people instant access to vast knowledge and computing power via thought alone.

In October 2018, E&Texplored advances in neuroimaging which could pave way for researchers to observe brain activity in real-time, investigating how these new techniques could reshape the way mental illness is diagnosed and treated.

Sign up to the E&T News e-mail to get great stories like this delivered to your inbox every day.

Read more from the original source:
Machine learning constructs map of the brain's neural circuit - E&T Magazine

Ongoing advancements in cancer research continue to lead to the introduction of newer and better treatment options including drug therapies. The provision of newer drugs and treatments is expected to improve the diagnostic and treatment rate for triple-negative breast cancer. Some of the recent clinical efforts are being targeted at the molecular level characterization of triple-negative breast cancer across emerging therapeutic targets such as epigenetic proteins, PARP1, androgen receptors, receptor and non-receptor tyrosine kinases, and immune checkpoints. These initiatives are anticipated to boost revenue growth of the triple-negative breast cancer treatment market. In a new research study, Persistence Market Research estimates the globaltriple-negative breast cancer treatment marketrevenue to cross US$ 720 Mn by 2026 from an estimated valuation of just under US$ 505 Mn in 2018. This is indicative of a CAGR of 4.7% during the period 2018 to 2026.

Development of generics is another key opportunity area in the triple-negative breast cancer treatment market. With the rapidly expanding number of cancer cases across the world, there is a need for effective cancer management, including the provision of better and more efficient drugs. Developing economies are faced with challenges on several fronts including paucity of funds and lack of proper treatment options, calling for more innovative approaches to affordable healthcare. The availability of biosimilars and affordable generic anti-cancer drugs in developing regions is expected to significantly reduce the burden of cancer care. A projected cost reduction to the tune of more than 30% 40% and extended use of generic drugs is expected to reduce overall cancer treatment costs, thereby increasing the treatment rate for triple-negative breast cancer. This is further anticipated to create lucrative growth opportunities in the global triple-negative breast cancer treatment market.

Advances in Cancer Treatment and Introduction of Innovative Cancer Treatment Drugs to Boost Revenue Growth of the Triple-Negative Breast Cancer Treatment Market

Breast cancer is one of the most common types of cancer in women, and over the years, pharmaceutical and life sciences companies have been conducting advanced research and development activities to devise newer treatment options and drugs to treat breast cancer. Several new drug formulations are currently in the pipeline in different stages of clinical development and this is expected to bode well for the triple-negative breast cancer treatment market. Innovation in oncology therapeutics has shifted focus towards an outcome based approach to cancer care, with an increasing emphasis on combination drugs and newer therapeutic modalities. This is further likely to put the global triple-negative breast cancer treatment market on a positive growth trajectory in the coming years.

Combination Therapy and Advancements in Nano Medicine Research Trending the Triple-Negative Breast Cancer Treatment Market

One of the biggest trends being observed in the global market for triple-negative breast cancer treatment is the shift towards combination therapy. Companies in the global triple-negative breast cancer treatment market are conducting clinical trials for combination therapies by collaborating with other players in the market. Combination therapies are the latest innovation in the field of oncology and the combination of therapeutic drugs with chemotherapy is said to be an effective protocol for the treatment of triple-negative breast cancer.

Another huge trend in the triple-negative breast cancer treatment market is the emergence of nanotechnology as an efficient tool in the clinical management of critical diseases such as triple-negative breast cancer. It has been observed that the combination of gold nanoparticles and folic acid results in higher cell entry rate in both in-vitro and in-vivo models, indicative of the fact that folate receptors are effective targeted therapies for the treatment of triple-negative breast cancer. Nanoparticles facilitate systematic and efficient delivery of drugs and agents to the site of the tumor. Advanced R&D in nanotechnology and nano medicine is one of the top trends likely to impact the global triple-negative breast cancer treatment market in the years to come.

Read the rest here:
Triple Negative Breast Cancer Treatment Market is Countable to Translate to a Revenue of CAGR 4.7% by 2018 to 2026 in Step With Market Forecast -...

Medical technologies like smart pills, vaccines personalization, and more are opening newer ways for cancer treatment.

FREMONT, CA: Treatment options for cancer have massively evolved and improved in recent years. Today, care providers continue to explore new possibilities for cancer treatment with the help of advanced technologies. Treatments like radiation therapy, personalization of cancer vaccines, and nano-medicines, experience rapid adoptions by care providers for cancer treatment.

1. Radiation Therapy

Health care providers use radiation therapy, highly effective cancer treatment. This treatment aims accurately and directly at the cancer cells, resulting in the killing or reduction of the tumor-affected cells and tissues in the patients. The high-energy rays prove to be highly effective in reducing the risk of cancer and recurrence of common cancer, such as breast cancer, bowel cancer, and prostate cancer, and helps the surgeons remove or kill the cancer-affected tissues. The latest medical technologies for cancer integrated with radiation therapy are making the treatments more quick, accurate, and effective.

2. Ingestible Sensors and Smart Pills

Ingestible technology in the healthcare field is used to help the patients manage their medications. The new technology allows the care providers to ensure their cancer patients are taking medications as prescribed. Ingestible sensors offer close monitoring of patients' health conditions, which include sensing the growth of tumors and instantly guiding the smart pills towards precise tumor locations and heart rate, activity level, and sleep cycle of the patients. The digital pills enable real-time transmission of health information to a small patch on the patients' skin, which can be connected to a mobile app that both the patients and their doctors can access.

3. Personalized Cancer Vaccines

Developments in personalized cancer vaccines enable the next-generation cancer treatment method. The advanced vaccine is used with the computational pipeline, which can precisely identify tumor-unique mutations and successfully induce immune responses in cancer patients, helping them fight their diseases. The technique follows cell-based immune therapies that provide the patients with tumor-attacking T cells, and the delivered neo-antigens in the patients body create vaccines to stimulate the T cells. The advanced vaccines are given in the form of messenger RNA that produces a particular protein according to the patients physiological requirements.

4. Nano-Medicines

The innovative and promising technology, nano-medicine provides many advantages over conventional cancer therapies and new opportunities for early detection, improved treatment, and diagnosis of cancer. The benefits of nano-medicines for cancer treatment attract care providers, as the unique physical, chemical, mechanical, and optical properties of these medicines are easier to access with more efficiency. The innovative medicine uses nano-carriers to deliver therapeutic molecules, such as drugs, proteins, or nucleic acids. The nano-structures for the cancer treatment can also be exploited to favor the delivery of immune agents and represent therapeutic tool.

Technology leads the cancer treatment sector towards a bright future, where the increasing advantages of innovative cancer treatment solutions can be accessed easily across the world. Nanotechnology, targeted radiation, personalized vaccines are revolutionizing the medical technology industry, promising the possibilities of more solutions that can successfully fight cancer and prevent its reoccurrence. The ever-evolving field of cancer treatments consistently puts effort into exploring innovative diagnostics and treatments, leading to more creative solutions like molecular cancer diagnostics, identify genetic and lifestyle causes of diseases, and perform precision surgery.

Link:
4 Innovative Solutions Fostering Advanced Cancer Treatment - Medical Tech Outlook

PITTSBURGH, Oct. 23, 2019 /PRNewswire/ -- While major drug companies reached a $260 million settlement to avert a federal opioid trial this week, the crisis continues to impact Americans. Researchers at Duquesne University think they have some answers.

Here's How We Can End the Opioid Crisiswill feature brief presentations from members of Duquesne's Chronic Pain Research Consortium, including:

The 45-minute session will begin at 9:30 a.m. on Thursday, October 24. To view the presentation live, click here.

The session is part of Duquesne's Integrative Health Summit, which highlights the university's growing momentum in health sciences education and research. Other sessions will focus on new treatments for deadly diseases; children and family health issues, including the anti-vaccine movement; how integrative techniques help serve marginalized populations, including sexual assault victims and those dealing with violence-related trauma; and the role of the arts in medicine.

Earlier this year, Duquesne announced that it's creating a College of Osteopathic Medicine to help meet a looming physician shortage in the U.S.

Duquesne UniversityFounded in 1878, Duquesne is consistently ranked among the nation's top Catholic universities for its award-winning faculty and tradition of academic excellence. Duquesne, a campus of nearly 9,500 graduate and undergraduate students, has been nationally recognized for its academic programs, community service and commitment to sustainability. Follow Duquesne University on Facebook, Twitter and Instagram.www.duq.edu

Excerpt from:
Researchers Explore How to End the Opioid Crisis at Web Event Tomorrow - Bradford Era

SOUTH SAN FRANCISCO, Calif. and TAIPEI, Taiwan, Oct. 21, 2019 (GLOBE NEWSWIRE) -- TLC (Nasdaq: TLC, TWO: 4152), a clinical-stage specialty pharmaceutical company developing novel nanomedicines to target areas of unmet medical need in pain management, ophthalmology and oncology, recently presented data at the American Society of Anesthesiologists (ASA) ANESTHESIOLOGY annual meeting from a Phase I/II clinical trial which showed TLC590 to yield more immediate and long-lasting pain reduction than ropivacaine. In addition, in vivo findings in which TLC590 showed no dose-related toxicity and other preclinical data were recently published in the International Journal of Nanomedicine. TLC590 is a non-opioid, BioSeizer formulation of ropivacaine with the aim to manage postsurgical pain for four to seven days with a single dose, potentially deterring the use of opioids following surgery.

At ANESTHESIOLOGY 2019, which took place October 19-23 at the Orange County Convention Center in Orlando, FL, principal investigator Todd Bertoch, MD, Chief Medical Officer at JBR Clinical Research, a CenExel Clinical Research Center of Excellence, presented findings from a Phase I/II, randomized, double-blind, comparator-controlled, dose-escalation study of TLC590 following inguinal hernia repair.

Highlights from the e-poster presentation are as follows:

I am delighted to have had the opportunity to present these fantastic results, said Dr. Todd Bertoch. As a clinical researcher specializing in pain, it is so rewarding to be able to share findings that provide hope for a real, substantive weapon in the war against opioids. Clinicians have been waiting patiently for safe, easily administered, very long acting local anesthetics with a rapid onset. These data suggest that we may have found one.

Results of studies evaluating the release profile of TLC590 in vitro and its pharmacokinetics and anesthetic effect in vivo were recently published in the International Journal of Nanomedicine.

Highlights from the publication article are as follows:

The poster presentation and full text article can be accessed under Publications in the Pressroom section of TLCs website at http://www.tlcbio.com.

About TLC590

TLC590 is a non-opioid, BioSeizer sustained release formulation of ropivacaine designed to prolong the retention time of ropivacaine around the injection site as a drug depot, simultaneously extending its therapeutic period and reducing unwanted systemic exposure. A Phase II, randomized, double-blind, comparator- and placebo-controlled clinical trial to evaluate the safety, pharmacokinetics and efficacy of TLC590 following bunionectomy is ongoing.

About TLC

TLC (NASDAQ: TLC, TWO: 4152) is a clinical-stage specialty pharmaceutical company dedicated to the research and development of novel nanomedicines that maximize the potential of its proprietary lipid-assembled drug delivery platform (LipAD). TLC believes that its deep experience with liposome science allows a combination of onset speed and benefit duration, improving active drug concentrations while decreasing unwanted systemic exposures. TLCs BioSeizer technology is designed to enable local sustained release of therapeutic agents at the site of disease or injury; its NanoX active drug loading technology is designed to alter the systemic exposure of a drug, potentially reducing dosing frequency and enhancing distribution of liposome-encapsulated active agents to the desired site. These technologies are versatile in the choice of active pharmaceutical ingredients, and scalable with respect to manufacturing. TLC has a diverse, wholly owned portfolio of therapeutics that target areas of unmet medical need in pain management, ophthalmology, and oncology.

Cautionary Note on Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements contained in this press release include, without limitation, statements regarding TLCs expectations regarding the clinical development of TLC590, the clinical benefits of TLC590 for postsurgical pain management, the timing, scope, progress and outcome of the clinical trials, and the anticipated timelines for the release of clinical data. Words such as may, believe, will, expect, plan, anticipate, estimate, intend and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) are intended to identify forward-looking statements. These forward-looking statements are not guarantees of future performance and involve a number of risks, assumptions, uncertainties and factors, including risks that the outcome of any clinical trial is inherently uncertain and TLC590 or any of our other product candidates may prove to be unsafe or ineffective, or may not achieve commercial approval. Other risks are described in the Risk Factors section of TLCs annual report on Form 20-F for the year ended December 31, 2018 filed with the U.S. Securities and Exchange Commission. All forward-looking statements are based on TLCs expectations and assumptions as of the date of this press release. Actual results may differ materially from these forward-looking statements. Except as required by law, TLC expressly disclaims any responsibility to update any forward-looking statement contained herein, whether as a result of new information, future events or otherwise.

Read more:
TLC Presents Clinical and Preclinical Data of TLC590 at ANESTHESIOLOGY Annual Meeting and in International Journal of Nanomedicine TLC590 showed...

Rizia Bardhan

With a research specialty in nanomedicine and nanophotonics and designing materials that fight diseases using image-guided techniques Rizia Bardhan will join the faculty of the Department of Chemical and Biological Engineering in January, 2020.

Bardhan, who has been hired as a tenured associate professor, comes to Iowa State from Vanderbilt University, where she has been an assistant professor in the Department of Chemical and Biomolecular Engineering since 2012.

Her research focuses on designing nanomaterials that can be activated by external stimuli and then utilize them for biomedical imaging, and image-guided drug delivery and immunotherapies across many disease models, including cancer, neurodegenerative disease and infection. She also develops point of care diagnostics that she is currently applying for early detection of preterm birth in pregnant women. Click here for more on her current research.

Prior to joining the faculty of Vanderbilt University she was a postdoctoral fellow at The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA.

She received a B.A. in mathematics and chemistry at Westminster College, Fulton, Missouri, in 2005 and a Ph.D. in chemistry at Rice University in 2010 under the guidance of Prof. Naomi Halas, a pioneer in nanophotonics and plasmonics.

In the 2020 spring semester at Iowa State she will teach ChE 381, chemical engineering thermodynamics.

Outside of research and teaching, Bardhan enjoys spending time outdoors with her two sons Elan (3) and Jonah (5), and husband Cary Pint, who is also a new Iowa State University faculty member, joining the Department of Mechanical Engineering in January.

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New CBE professor Bardhan to bring image-guided techniques to fight against disease College of Engineering News Iowa State University - Iowa State...

Nanorobotic is a new technology of robot engineering. The development of nano-robot belongs to molecular nanotechnology

Nanorobotic Marketreport offers a comprehensive valuation of the marketplace. It does so via in-depth comprehensions, grateful market growth by pursuing past developments, and studying the present situation and future forecasts based on progressive and likely areas. Each research report supports as a depository of analysis and data for each and every side of the industry, including but not limited to: Regional markets, types, applications, technology developments and the competitive landscape.

The Nanorobotic Market report profiles the following companies, which includes: Bruker, Jeol, Thermo Fisher Scientific, Ginkgo Bioworks, Oxford Instruments, Ev Group, Imina Technologies, Toronto Nano Instrumentation, Klocke Nanotechnik, Kleindiek Nanotechnik, Xidex, Synthace, Park Systems, Smaract, Nanonics Imaging

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Report Description:-

This report presents a comprehensive overview, market shares and growth opportunities of Nanorobotic market by product type, application, key companies and key regions.

In addition, this report discusses the key drivers influencing market growth, opportunities, the challenges and the risks faced by key players and the market as a whole. It also analyzes key emerging trends and their impact on present and future development.

Product Type Coverage:-Nanomanipulator, Bio-Nanorobotic, Magnetically Guided Robot

Product Application Coverage:-Nanometer Medicine, Biomedical, Machine, Other

Market Segment by Regions, regional analysis coversNorth America (United States, Canada and Mexico)Europe (Germany, France, UK, Russia and Italy)Asia-Pacific (China, Japan, Korea, India and Southeast Asia)South America (Brazil, Argentina, Colombia etc.)Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

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Table of Content:

1 Report Overview1.1 Study Scope1.2 Key Market Segments1.3 Players Covered1.4 Market Analysis by Type1.5 Market by Application1.6 Study Objectives1.7 Years Considered

2 Global Growth Trends2.1 Nanorobotic- Market Size2.2 Nanorobotic- Growth Trends by Regions2.3 Industry Trends

3 Market Share by Key Players3.1 Nanorobotic- Market Size by Manufacturers3.2 Nanorobotic- Key Players Head office and Area Served3.3 Key Players Nanorobotic- Product/Solution/Service3.4 Date of Enter into Nanorobotic- Market3.5 Mergers & Acquisitions, Expansion Plans

4 Breakdown Data by Product4.1 Global Nanorobotic- Sales by Product4.2 Global Nanorobotic- Revenue by Product4.3 Nanorobotic- Price by Product

5 Breakdown Data by End User5.1 Overview5.2 Global Nanorobotic- Breakdown Data by End User

Research objectives

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Nanorobotic Market 2019 Technological Perspective, Latest Trends and key manufacturers:: Bruker, Jeol, Thermo Fisher Scientific, Ginkgo Bioworks -...

Los Angeles, United States, In a recent study published by QY Research, titled, Nanobots Market Research Report, analysts offers an in-depth analysis of global Nanobots market. The study analyses the various aspect of the market by studying its historic and forecast data. The research report provides Porters five force model, SWOT analysis, and PESTEL analysis of the Nanobots market. The different areas covered in the report are Nanobots market size, drivers and restrains, segment analysis, geographic outlook, major manufacturers in the market, and competitive landscape.

The report provides accurate historic figures and estimates about the future to the readers. The report also mentions the expected CAGR of the global Nanobots market during the forecast period.

Get PDF template of this report: https://www.qyresearch.com/sample-form/form/1148108/global-nanobots-market-report-history-and-forecast-2014-2025-breakdown-data-by-manufacturers-key-regions-types-and-application

Key manufacturers in the Nanobots market:

The report lists some of the key manufacturers operating in the global Nanobots market. Their revenue data, shares in the market, historic and forecast are all covered in this section.

Xidex CorpZymergen IncSynthace LimitedGinkgo BioworksAdvanced Diamond TechnologiesAdvanced Nano Products Co Limited

Segment Analysis of the Nanobots market:

The segment analysis of the Nanobots market includes the major two segments as type and application, and end user. Such a segmentation enables a granular view of the market that is imperative to understand the finer nuances.

Global Nanobots Market by Type Segments:

Microbivore NanorobotsRespirocyte NanorobotsClottocyte NanorobotsCellular Repair Nanorobots

Global Nanobots Market by Application Segments:

Nano MedicineBiomedicalMechanicalOther applications

Geographical Outlook of the Nanobots market:

The geographic outlook of the Nanobots market contains analysis of all the regions which occupy the regional shares of the market. This section provides you with all the information about the revenue generated by different regions from import, export, and manufacturing.

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Scope of Global Nanobots Market

The research report gives a wide overview of the new and emerging trends in the Nanobots market. The report provides an assessment of the strengths and weaknesses of the market along with the other factors which are expected to hinder the market. It also explains the dynamics of Nanobots market in detail for a comprehensive understanding.

The drivers in the Nanobots market are all the external factors which are expected to contribute towards its growth. It contains the data from different industries which are expected to grow and create more demand and opportunities for the products in the future. This will help reader understand the trajectory of the Nanobots market for making sound investments and better business decisions.

The restraints in the Nanobots market includes all the factors which might hamper its growth in future. Studying the market restraints will help readers understand the challenges the Nanobots market might face. It will also help them take necessary measures to avert loses. In addition, the report also includes a list of opportunities present in the global Nanobots market.

The Nanobots market scope will allow the reader to have all the necessary information of the Nanobots market that might be helpful to the readers.

Competitive Landscape of the Nanobots market:

Competitive landscape studies new strategies being used by different manufacturers for increasing the competition or maintain their position in the Nanobots market. Strategies such as product development, innovative technologies, mergers and acquisitions, and joint ventures are covered in the research report. This will help the reader understand the current trends that are growing at a fast pace. It will also update the reader about the new products which are replacing the traditional once. All this has been explained in complete detail for absolute clarity.

About Us:

QYResearch always pursuits high product quality with the belief that quality is the soul of business. Through years of effort and supports from the huge number of customer supports, QYResearch consulting group has accumulated creative design methods on many high-quality markets investigation and research team with rich experience. Today, QYResearch has become a brand of quality assurance in the consulting industry.

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Nanobots Market Size Trends, Revenue, Regional Segmented Analysis and Outlook 2025 - Update in Seconds

HAYWARD, Calif.--(BUSINESS WIRE)--Pulse Biosciences, Inc. (Nasdaq: PLSE), a novel bioelectric medicine company bringing to market its proprietary CellFX System harnessing Nano-Pulse Stimulation (NPS) technology, today announced that it will present results of three clinical studies demonstrating high clearance rates across its benign skin lesion portfolio during the upcoming American Society for Dermatologic Surgery (ASDS) annual meeting on October 24-27, in Chicago. The data will span the companys CellFX procedure using NPS non-thermal energy in clearing Sebaceous Hyperplasia lesions, non-genital warts and back acne. The cellular-specific NPS technology was also selected to be featured at the opening Plenary Session, which highlights cutting-edge science and emerging therapies in dermatologic surgery.

The breadth and depth of the clinical data we are presenting at ASDS points to the tremendous progress we are making collaboratively to advance our CellFX System across a broad range of benign lesions, said Darrin Uecker, President and Chief Executive Officer of Pulse Biosciences. These results reflect the ongoing commitment needed to introduce the CellFX System into the clinic to improve clinical outcomes and quality of life for patients.

In prior studies, investigator assessments concluded that the NPS procedure met efficacy endpoints in 99.5% of Sebaceous Hyperplasia lesions and 82% of Seborrheic Keratosis lesions along with normal and expected skin recovery periods. NPS technology delivers nano-second pulses of electrical energy to non-thermally clear cells while sparing adjacent healthy, non-cellular tissue.

Dr. Tom Rohrer, a dermatologic surgeon in private practice at SkinCare Physicians in Boston, MA, and former president of the ASDS, will spotlight NPS technology in his lecture at the Emerging Therapies plenary of the Societys annual meeting.

I am excited to share the science and clinical data on NPS technology because it is a first-of-its-kind bioelectric technology that is genuinely different from existing energy-based devices, said Thomas Rohrer, MD. In our clinical experience, as well as in peer-reviewed published studies, the cellular mechanism of NPS energy points to a rapidly evolving and dynamic new technology with a tremendous amount of upside for our patients.

ORAL PRESENTATIONS:

Abstracts

Lead Authors

Key Findings

Schedule

First Clinical Use of Non-Thermal Nano-Pulse Stimulation Technology for Treating Cutaneous, Non-Genital Warts [Feasibility Study]

E. Victor Ross, MD,Girish Munavalli, MD

The high rate of wart size reduction suggests the utility of the unique NPS cellular mechanism for the treatment of non-genital, cutaneous warts. In two instances, the control wart showed 100% reduction in size, suggesting there may be an immune response. Based on these initial results, a larger pivotal study is warranted and will be conducted in the future.

Thursday,October 24th7:30 - 8:45 amCentral Time

GeneralDermatology

Oral Abstracts

A Feasibility Study for the Treatment of Moderate to Severe Acne Vulgaris of the Back Using Nano-Pulse Stimulation Energy

Mark S. Nestor, MD,

Brian Berman, MD,Jessica Jones, DO,Taraneh Matin, DO

Initial data of two male patients suggests the positive effect of treating back acne with NPS energy. A larger study is needed to validate these promising early results and to focus on achieving similar acne lesion reduction efficacy while minimizing the rate and extent of hyperpigmentation.

ThursdayOctober 24th8:23 - 8:25 am

General DermatologyOral Abstracts

Emerging Therapies in Dermatologic Surgery

Thomas Rohrer, MD

An overview of the science, mechanism and clinical uses of Nano-Pulse Stimulation technology for clearing benign and malignant skin lesions.

Thursday,October 24th10:45a Noon

Plenary Session

A Multicenter, Pivotal Study Using the Nano-Pulse Stimulation Procedure to Treat Sebaceous Hyperplasia Lesions [Optimization Study]

Girish Munavalli, MD

Brian Zelickson, MD,Suzanne Kilmer, MD,Brenda LaTowsky, MD,

Elizabeth Tanzi, MDAva Shamban, MD

This second study of SH lesions evaluated the use of lower energy levels for relative efficacy and recovery periods, as well as lower side effect profiles.

The data reaffirms that NPS technology is an effective method for safely clearing SH lesions. The reduced energy levels utilized in this study demonstrated similar levels of efficacy as in the previous study, while reducing the time of normal skin recovery and decreasing the rate and duration of residual skin effects, such as hyperpigmentation and volume loss.

Thursday,October 24th3:00- 3:05 pm

Cosmetic DermSurgery OralAbstracts

About Pulse Biosciences

Pulse Biosciences is a novel bioelectric medicine company committed to health innovation that improves and potentially extends the lives of patients. The CellFX System is the first planned commercial product to harness the distinctive advantages of the Companys proprietary Nano-Pulse Stimulation (NPS) technology to treat a variety of applications for which an optimal solution remains unfulfilled. NPS technology delivers nano-second pulses of high amplitude electrical energy to non-thermally clear cells while sparing adjacent non-cellular tissue. The cell-specific effects of NPS technology have been validated in a series of ongoing clinical trials. The CellFX System is preparing to launch in 2019 as a multi-application platform designed to address a broad range of dermatologic conditions. As part of the customer experience, the Company is offering a utilization-based revenue model and easy-access customer portal offering a suite of services. CellFX procedures offer customer value across an expanding spectrum of clinical applications. The initial commercial use will be in the clearance of common and difficult to treat skin lesions that share high demand among patients and practitioners for improved and durable aesthetic outcomes that lead to greater overall satisfaction.

Caution: Pulse Biosciences CellFX System and Nano-Pulse Stimulation technology are for investigational use only.

Forward-Looking Statements

All statements in this press release that are not historical are forward-looking statements, including, among other things, statements relating to Pulse Biosciences expectations regarding regulatory clearance and the timing of FDA filings or approvals, the mechanism of action of NPS treatments, current and planned future clinical studies, other matters related to its pipeline of product candidates, future financial performance and other future events. These statements are not historical facts but rather are based on Pulse Biosciences current expectations, estimates, and projections regarding Pulse Biosciences business, operations and other similar or related factors. Words such as may, will, could, would, should, anticipate, predict, potential, continue, expects, intends, plans, projects, believes, estimates, and other similar or related expressions are used to identify these forward-looking statements, although not all forward-looking statements contain these words. You should not place undue reliance on forward-looking statements because they involve known and unknown risks, uncertainties, and assumptions that are difficult or impossible to predict and, in some cases, beyond Pulse Biosciences control. Actual results may differ materially from those in the forward-looking statements as a result of a number of factors, including those described in Pulse Biosciences filings with the Securities and Exchange Commission. Pulse Biosciences undertakes no obligation to revise or update information in this release to reflect events or circumstances in the future, even if new information becomes available.

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Pulse Biosciences Presents Data From Several Clinical Studies of Nano-Pulse Stimulation Technology to Clear Skin Lesions at the 2019 ASDS Annual...

The Healthcare Nanotechnology Market research report is provided with the information categorizing by parameters such as players, brands, regions, types and application. The report also illustrates the information about the global market status, competition landscape, growth rate, future trends, market drivers, challenges and opportunities and porters forces analysis with respect to these elements.

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You get the detailed analysis of the current market scenario for Healthcare Nanotechnology and a market forecast till 2024 with this report. The forecast is also assist with the elements affecting the market dynamics for the forecast period. This report also details the information related to geographic trends, competitive scenarios and opportunities in the Healthcare Nanotechnology market. The report is also providing with SWOT analysis and value chain for the companies which are profiled in this report.

Key Players of Healthcare Nanotechnology Market:

AmgenStrykerTeva PharmaceuticalsUCBRocheAbbottMerck & Co

This report also covers the study relating to the key regions for the global market size for the Healthcare Nanotechnology such as North America, Europe, Asia Pacific, South America, Middle East, Africa etc. and focuses on the consumption of Healthcare Nanotechnology in these regions.

This comprehensive research covers all the important information pertaining to the Healthcare Nanotechnology market. For this study, Reports Intellect has conducted all-encompassing primary research with key players to collect first had data. Moreover, in-depth interviews with main leaders also assisted in the validation of findings from secondary research and to understand key trends in the Healthcare Nanotechnology market. Primary research makes up the main source of information gathering and validation

Segmentation by product type:NanomedicineNano Medical DevicesNano DiagnosisOther

Segmentation by application:AnticancerCNS ProductAnti-infectiveOther

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Table of Contents

2019-2024 Global Healthcare Nanotechnology Market Report (Status and Outlook)

1 Scope of the Report

1.1 Market Introduction

1.2 Research Objectives

1.3 Years Considered

1.4 Market Research Methodology

1.6 Currency Considered

2 Executive Summary

2.1 World Market Overview

2.1.1 Global Healthcare Nanotechnology Market Size 2014-2024

2.1.2 Healthcare Nanotechnology Market Size CAGR by Region

2.2 Healthcare Nanotechnology Segment by Type

2.3 Healthcare Nanotechnology Market Size by Type

2.3.1 Global Healthcare Nanotechnology Market Size Market Share by Type

2.3.2 Global Healthcare Nanotechnology Market Size Growth Rate by Type

2.4 Healthcare Nanotechnology Segment by Application

2.5 Healthcare Nanotechnology Market Size by Application

2.5.2 Global Healthcare Nanotechnology Market Size Growth Rate by Application (2014-2019)

Reasons Why You Should Buy This Report?

About Us:

Reports Intellect is your one-stop solution for everything related to market research and market intelligence. We understand the importance of market intelligence and its need in todays competitive world.

Our professional team works hard to fetch the most authentic research reports backed with impeccable data figures which guarantee outstanding results every time for you.

So whether it is the latest report from the researchers or a custom requirement, our team is here to help you in the best possible way.

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Healthcare Nanotechnology Market 2019 Will Generate New Growth Opportunities In The Upcoming Year | - Global Market Release

Your sneak preview of the future is the slogan of Innovation Origins, and thats just what we will highlight with our Start-up of the Week column. Over the past few days, five start-ups of the day have been featured and on Saturday we will choose the weeks winner.

Innovation Origins presents a Start-up of the Day each weekday

We shall consider various issues such as sustainability, developmental phase, practical application, simplicity, originality and to what extent they are in line with theSustainable Development Goals of UNESCO. They will all pass by here and at the end of the week, the Start-Up of the Week will be announced.

Moreover, our weekly winners may be awarded another prize. Because at the end of each calendar month, our readers, together with the editors of IO, will select the Start-up of the Month!

The way we use medicines is still somewhat primitive. Maybe thats not surprising, because our options are limited when it comes to taking medication. Most organs are well protected from the outside world. Nevertheless, this also means that medicines cannot be administered very effectively. Dosages are therefore often higher than necessary because they have to travel a long way through our bodies.

Sovigo wants to change this through nanotechnology. Their capsules are about 100 nanometres in size, which is 10,000th of a millimeter (!) The main advantage is that this nanomedicine is effective solely at the point where the medication is actually needed. Preliminary results are encouraging for treating intestinal disorders.

Climate change and dwindling agricultural land are major challenges for food and feed production. The supply of animal protein is particularly problematic.

The start-up Blue Planet Ecosystems, based in San Francisco and Vienna, wants to shift pisciculture (fish farming) to computerized container systems. The ecosystem is to be simulated in such a way that nature is able to grow in self-sustaining LARA systems (Land-based Automated Recirculating Aquaculture).

Lara Systeme (c) Blue Planet Ecosystems

This German start-ups drone system has brought a new automation revolution to warehouses. The flying assistants are able to make an inventory of a warehouse on their own by making a kind of digital impression of it. At present, maintaining a warehouse is a time-consuming task. Doks. Innovation promises a time gain of no less than 90% and a cost reduction of 80%. Data collected by the drones are subsequently made available in a proprietary data analysis system. Similar concepts are focused on a single management system as a rule, whereas Doks offers a universal system.

Giving freedom back to people who have limited freedom of movement. Thats the noble goal that former snowboarder Patrick Mayer has committed himself to. Mayer ended up in a wheelchair for a long time himself and personally experienced how winter can throw a spanner in the works. Moving through snow and over ice in a wheelchair or with crutches is just not much fun.

Which is why he came up with Wheelblades, a kind of mini-snowboard that gives more stability to the front wheels. For people on crutches, there is the SafetyFoot, an extra foothold for underneath crutches. And Wheelblades are also suitable for prams, so that you are able to go on a winter hike with your little one without any hassles.

Recharging: it is perhaps the greatest sore point that is associated with electric mobility. Compared to traditional refueling, it takes ages before you can get back on the road. If its up to the Israeli start-up Chakratec, this will soon be a thing of the past. Their kinetic battery fills up about as fast as your diesel tank does. Yet the potential is even greater: the battery has unlimited charging cycles and contains no pollutants.

They are setting their sights on a heroic reputation. A start-up for the benefit of humankind. What makes this mission even more challenging, is that the market in which they have delved into is dominated by Chinese companies. How do you stand out? The solution is simple and difficult at the same time. Come up with something completely new. The result is a kinetic battery with flywheel technology.

A battery can be highly innovative; but without a good charger it is of little use. Chakratec maintains that current infrastructure has been overwhelmed by reality and is suffering from too much red tape. It would be possible to create fast charging stations anywhere, even with a weak network, with the relevant fast charging technology.

The potential of Chakratecs technology has not gone unnoticed. The start-up has already won several awards, including one for best storage technology. They can add another feather in their cap because the favorable prospects for Chakratec make it the Start-up of the Week!

There is a frantic search going on around the world for efficient and sustainable batteries and the subject is also regularly addressed by Innovation Origins. At the beginning of this month, for example, we spoke to the start-up High Performance Battery, which is also trying to bring a new type of smartphone battery onto the market. Or does the future for cars lie with hydrogen technology? We sought answers to that question here in this series.

Innovation Origins is an independent news platform, which has an unconventional revenue model. We are sponsored by companies that support our mission: spreading the story of innovation. Read more here.

On Innovation Origins you can always read articles for free. We want to keep it that way. Have you enjoyed this article so much that you want to contribute to independent journalism? Click here:

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Start-up of the week: charging your car can be done in minutes - Innovation Origins

Fact Sheets about Genomics | NHGRI Skip to main content

The National Human Genome Research Institute (NHGRI) has produced this series of fact sheets to explain complex concepts in genomics research to a non-scientific audience. Teachers, students and the general public alike will find the materials clearly written and easy to understand.

A biological pathway is a series of actions among molecules in a cell that leads to a certain product or a change in the cell.

Genomics is the study of all of a person's genes (the genome), including interactions of those genes with each other and with the person's environment.

Chromosomes are thread-like structures located inside the nucleus of animal and plant cells.

Cloning describes a number of different processes that can be used to produce genetically identical copies of a biological entity.

Comparative genomics is a field of biological research in which researchers compare the complete genome sequences of different species.

DNA sequencing determines the order of the four chemical building blocks - called "bases" - that make up the DNA molecule.

Epigenomics is a field in which researchers chart the locations and understand the functions of all the chemical tags that mark the genome.

Genetic mapping offers evidence that a disease transmitted from parent to child is linked to one or more genes and clues about where a gene lies on a chromosome.

A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.

Newborn screening tests use a dried blood sample collected during the first week after birth to measure the presence of disease biomarkers.

Data used to estimate the cost of sequencing the human genome over time since the Human Genome Project.

The X chromosome determines your sex, gives some females super color vision and lends its magic to a certain breed of cat.

The Y chromosome of all living men is related through a single male ancestor who lived over 100,000 years ago.

Genetics refers to the study of genes and their roles in inheritance. Genomics refers to the study of all of a person's genes (the genome).

Last updated: November 9, 2015

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Fact Sheets about Genomics | NHGRI - genome.gov

Pharmaceutical Nanotechnology & Nanomedicine Congress 2019

LexisConferencesconsider it a privilege and a matter of great pride to host Conference on Pharmaceutical Nanotechnology & Nanomedicine Congressis to be held at Venice, Italyfor the duration of September13-14, 2019. On this auspicious occasion, Organizing Committee invites the participants from all over the world to take part in this annual flagship conference with the theme Exploring the Progress of Nanomedicinewith Trending Nanotechnologies. The conference will provide a forum for interaction among attendees on Pharmaceutical Nanotechnology, Development of Nanotechnology-enabled Devices, Micro Fluidics platform for Nano Particle Synthesis, Toxicology and Risk Assessment of Nanomedicine Systems, MedicalNano Devices and Biosensors, Synthesis of Nanoparticles for Drug Delivery, Nanomedicine for Immune System and Cancer Diagnosis & Therapy.

This global meeting will assemble the world leaders in the expanding fields related to Pharmaceutical Nanotechnology & Nanomedicine. It will create an interface among professionals, academic faculty members, Researchers, Nanotech representatives and students, Nanotechnologists, Manufacturing Medical Device and experts in the fields of Nanotechnology. industry practitioners.The Conference will also have a room for companies and/or institutions to present their services, products, revolutions and research results.

Global Market for Nanotechnology products was priced $22.9 billion in 2013 and unanticipated increased to about $26 billion in 2014. This market is await to reach about $64.2 billion by 2019; a compound annual growth rate (CAGR) is 19.8% from 2014 to 2019. The global market for nanotechnology-enabled printing technology was approximate to be at total $14 billion in 2013. The market is anticipate to grow at a compound annual growth rate (CAGR) of 17.7% over the next five years and to total $31.8 billion by 2018.

Details of Nanomedicine Congress 2019

Conference Name

Place

Date

Nanomedicine Congress 2019

Venice, Italy

September 13-14, 2019

Original post:
Nanomedicine Conferences 2019 | Nanotechnology Meetings ...

NLM ID: 101562615SJR H Index:16SJR 2017: 0.35ICDS 2017: 3.8

Nanomedicine is the application of nanotechnology which made its debut with greatly increased possibilities in the field of medicine. Nanomedicine desires to deliver research tools and clinically reformative devices in the near future.

Journal of Nanomedicine & Nanotechnology covers wide varieties of topics such as molecular nanotechnology, nanosensors, nanoparticles, nanodrugs, Nanomaterials, nanobiotechnology, nanobiopharmaceutics, nanoelectronics, nanorobotics, etc.. The journal includes a wide range of fields in its discipline to create a platform for the authors to make their contribution towards the journal and the editorial office promises a peer review process for the submitted manuscripts for the quality of publishing.

The journal is using Editorial Manager System for quality peer review process. Editorial Manager is an online manuscript submission, review and tracking systems. Review processing is performed by the editorial board members of Journal of Nanomedicine & Nanotechnology or outside experts; at least two independent reviewers approval followed by editor approval is required for acceptance of any citable manuscript. Authors may submit manuscripts and track their progress through the system, hopefully to publication. Reviewers can download manuscripts and submit their opinions to the editor. Editors can manage the whole submission/review/revise/publish process.

The Journal of Nanomedicine & Nanotechnology is a scientific journal which provides an opportunity to share the information among the medical scientists and researchers. The main function of open access publishing platforms is to present the content online, making it available to all, and link this information with useful scientific data.The Journal of Nanomedicine & Nanotechnology aims to publish articles bimonthly and is one of the best open access journals of scholarly publishing.

Journal of Nanomedicine & Nanotechnology is anacademic journal which aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of Research articles, Review articles, Case reports, Short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide.

You can find a clear view of peer review process by clicking here.

Material Science Research: Material Science and NanotechnoMaterials are crucial to the performance and reliability of virtually every technology and the vitality and health of any living organism. The central theme of materials science and engineering is that the process by which a material comes into being determines its structure, which in turn controls its properties and ultimately its functional performance.

Nanotechnology is the engineering of functional systems at the molecular scale. It is the study and application of extremely small things and can be used across all the other science fields, such as chemistry, biology, physics, materials science, and engineering.

Related Journals of NanotechnologyNanoscience and Nanotechnology, Nanoscience and Nanotechnology Letters, Journal of Nanomedicine & Biotherapeutic Discovery, IEEE Transactions on Nanobioscience, Journal of Biomedical Nanotechnology, Photonics and Nanostructures - Fundamentals and Applications

Nanobiotechnology is the application of nanotechnology to the life sciences: The technology encompasses precision engineering as well as electronics, and electromechanical systems as well as mainstream biomedical applications in areas as diverse as gene therapy, drug delivery and novel drug discovery techniques.

Related Journals of NanobiotechnologyJournal of Biomedical Nanotechnology, Research Journal of Nanoscience and nanotechnology, Nature Nanotechnology Journal, Nanomaterials & Molecular Nanotechnology, Nature Nanotechnology, Nano Letters, Advanced Materials, Nano Today

A Nanocomposite is a multiphase solid material where one of the phases has one, two or three dimensions of less than 100nm, or structure having nano-scale repeat distance between the different phases that make up the material.

Related Journals of Nanocomposites

Journal of Nanomaterial and Nanotechnology, International Journal of Nanotechnology Impact Factor, Journal of Nanomedicine & Biotherapeutic Discovery, Scripta Materialia, Nanoscale, Lab on a Chip - Miniaturisation for Chemistry and Biology, Materials Science & Engineering A: Structural Materials: Properties, Microstructure and Processing

The Integrated Project Nanobiopharmaceutics aims at the development of innovative multidisciplinary approaches for the design, synthesis and evaluation of functionalised nano-carriers and nano-particle-based micro-carriers for the treatment of various diseases based on targeted, controlled delivery of therapeutic peptides and proteins (biopharmaceutics).

Related Journals of NanobiopharmaceuticsJournal of Nanomedicine & Biotherapeutic Discovery, Journal of Nanobiomedical Impact Factor, Journal of Obsessive-Compulsive and Related Disorders, Journal of Homotopy and Related Structures, Journal of Venomous Animals and Toxins including Tropical Diseases

Nanoelectronics is one of the major technologies of Nanotechnology. It plays vital role in the field of engineering and electronics.

Related Journals of Nanoelectronics Journal of Nanotechnology and Electrophysics, Nano Research & Applications, ACS Applied Materials and Interfaces, International Journal of Nanotechnology Applications, Biosensors and Bioelectronics, Journal of Physical Chemistry C, Nanomedicine: Nanotechnology, Biology, and Medicine

Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials, to nanoelectronic biosensors, and even possible future applications of molecular nanotechnology.

Related Journals of Nanomedicine Nanomaterials & Molecular Nanotechnology, Pharmaceutical Nanotechnology, Journal of Biomedical Nanotechnology, International Journal of Nanomedicine, Nanomedicine: Nanotechnology, Biology and Medicine, Journal of Nanomedicine Research, European Journal of Nanomedicine

Nanotoxicology is a branch of toxicology concerned with the study of the toxicity of nanomaterials, which can be divided into those derived from combustion processes (like diesel soot), manufacturing processes (such as spray drying or grinding) and naturally occurring processes (such as volcanic eruptions or atmospheric reactions).

Related Journals of NanotoxicologyNanomedicine & Nanotechnology, Nanotechnology Journal Lists, Nano Journal Impact Factor, Microscale Thermophysical Engineering, Microelectronic Engineering, Nano Biomedicine and Engineering, Nano-Micro Letters

Nanoengineering is the practice of engineering on the nanoscale. It derives its name from the nanometre, a unit of measurement equalling one billionth of a meter. Nanoengineering is largely a synonym for nanotechnology, but emphasizes the engineering rather than the pure science aspects of the field.

Related Journals of NanoengineeringJournal of Nanoresearch, Review in Nanoscience and Nanotechnology, Nature Nanotechnology Journal, Research & Reviews: Journal of Pharmaceutics and Nanotechnology, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, Nanotoxicology, Precision Engineering, Nanomedicine, Nanotechnology

The spontaneous association of molecules under equilibrium conditions into stable, structurally well-defined aggregates.

Related Journals of NanofabricationsJournal of Nanotechnology Impact Factor, Nanotechnology Journal Lists, Journal of Nano, Nanomaterials & Molecular Nanotechnology, Microporous and Mesoporous Materials, International Journal of Nanomedicine, Beilstein Journal of Nanotechnology

Nanofluidics is often defined as the study and application of fluid flow in and around nanosized objects.

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Journal of Nanomedicine and Nanotechnology- Open Access ...

MESSAGE FROM CONFERENCE CHAIRS

WELCOME to Sydney Australia for the 10th International Nanomedicine Conference.

The annual International Nanomedicine Conference is regarded as the most significant nanomedicine meeting in the Southern Hemisphere.This event attracts approx. 250 registrants with representation from academia, medical research institutes and biotech companies. More than half of the delegates are from interstate and international organisations.

2019 marks the 10th Anniversary of this very successful conference. The Conference will be held from 24-26 June 2019 at Pier One Sydney Harbour Hotel for a special 10th Anniversary celebration. This event is again brought to you by the Australian Centre for NanoMedicine (ACN) and the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (CBNS). The main objective of the conference is to share novel research that may lead to prevention, diagnosis and/or treatment of some of the most challenging diseases,in an environment conducive to networking with colleagues from around the world.

We are fortunate to have five prominent scholars as our Plenary Speakers Professors Joe Wang, Milica Radisic, Chunying Chen, Ranjeny Thomas and Alan Rowan who will lead us through an exploration of our conference themes.

We will also showcase 15 Keynote speakers and 20 Invited speakers who will head discussions in the conference theme areasof Sensors and Imaging, Drug Delivery, Bioactive Materials, Social Aspects & Regulatory, Bio-Nano Interactions & Nanotoxicology, Industry Session and Microfluidic & Bioengineered Models. The unique Clinical Challenges session brings medical doctors into the conference to discuss opportunities for improving the treatment of patients in the clinic.

On behalf of the Conference Organising Committee, we look forward to welcoming you to the Conference!

Scientia Professor Justin Gooding

Professor Maria Kavallaris

Professor Tom Davis

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10th International Nanomedicine Conference 24-26 June ...

Nanomedicine is an application of nanotechnology which made its debut with greatly increased possibilities in the field of medicine. Nanomedicine desires to deliver research tools and clinically reformative devices in the near future.

Journal of Nanomedicine & Biotherapeutic Discovery is a scholarly open access journal publishing articles amalgamating broad range of fields of novel nano-medicine field with life sciences. Nanomedicine & Biotherapeutic Discovery is an international, peer-reviewed journal providing an opportunity to researchers and scientist to explore the advanced and latest research developments in the field of nanoscience & nanotechnology.

This is the best academic journal which focuses on the use nanotechnology in diagnostics and therapeutics; pharmacodynamics and pharmacokinetics of nanomedicine, drug delivery systems throughout the biomedical field, biotherapies used in diseases treatment including immune system-targeted therapies, hormonal therapies to the most advanced gene therapy and DNA repair enzyme inhibitor therapy. The journal also includes the nanoparticles, bioavailability, biodistribution of nanomedicines; delivery; imaging; diagnostics; improved therapeutics; innovative biomaterials; regenerative medicine; public health; toxicology; point of care monitoring; nutrition; nanomedical devices; prosthetics; biomimetics and bioinformatics.

The journal includes a wide range of fields in its discipline to create a platform for the authors to make their contribution towards the journal and the editorial office promises a peer review process for the submitted manuscripts for the quality of publishing. Biotherapeutics journals impact factors is mainly calculated based on the number of articles that undergo single blind peer review process by competent Editorial Board so as to ensure excellence, essence of the work and number of citations received for the same published articles.

The journal is using Editorial Manager System for quality peer review process. Editorial Manager is an online manuscript submission, review and tracking systems. Review processing is performed by the editorial board members of Journal of Nanomedicine & Biotherapeutic Discovery or outside experts; at least two independent reviewers approval followed by editor approval is required for acceptance of any citable manuscript. Authors may submit manuscripts and track their progress through the system, hopefully to publication. Reviewers can download manuscripts and submit their opinions to the editor. Editors can manage the whole submission/review/revise/publish process.

Submit manuscript at http://editorialmanager.com/chemistryjournals/ or send as an e-mail attachment to the Editorial Office at[emailprotected]

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Journal of Nanomedicine and Biotherapeutic Discovery- Open ...

This fast-evolving field uses nanoscale or nanostructured materials to impart unique pharmacokinetic and therapeutic effects such as enhanced dissolution rate and oral bioavailability, targeted delivery, enhanced efficacy and reduced toxicity.

The control of materials in the nanometer size range requires scientifically demanding chemistry, analysis and manufacturing techniques. Our nanomedicine expertise encompasses formulation, process and analytical development, GMP manufacturing and dossier development.

We are experts in the following formulations:

Once we identify a suitable formulation, our scientists develop phase-appropriate production processes in accordance with cGMP and mitigate technology transfer issues by using the same teams for development and manufacturing.

Techniques include:

In our cGMP-compliant manufacturing facilities, we can produce volumes of a couple of millilitres to multiple litres, using batch-type and continuous-flow processes. We also work with highly-potent drug substances and can deliver nanosuspensions and nanoparticle solutions as sterile finished drug products in vials or syringes.

To support product development and to perform quality control of GMP-produced drug products, we utilise state-of-the-art analytical techniques such as:

Having advanced a wide range of nanomedicine formulations into the clinic, we are used to developing new manufacturing techniques and analytical procedures under fierce regulatory scrutiny. Our understanding of the regulatory landscape gives your nanomedicine project the greatest chance of approval.

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Nanomedicine | Ardena