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Archive for the ‘Personalized Medicine’ Category

FDA Clearance for Hepatica, Perspectum’s Surgical Decision Support Tool for Liver Cancer – Business Wire

Sunday, January 31st, 2021

DALLAS--(BUSINESS WIRE)--Perspectum announced today that it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for Hepatica, a precision oncology decision support tool for liver cancer.

Each year, around 200,000 Americans are diagnosed with primary or secondary liver cancer, with surgery as one of the key treatment options. The success of surgery relies on the volume and health of the remaining liver, which is impacted by any underlying chronic liver disease (CLD). Fatty liver disease, chronic viral hepatitis B and C as well as alcoholic liver disease affect nearly 100 million Americans, with prevalence increasing. Accurate pre-surgical assessment of liver health is therefore urgently needed to improve the outcomes for patients.

Hepatica uses non-invasive quantitative multiparametric MRI to provide a liver health assessment based on AI-driven liver segmentation together with proprietary biomarkers for hepatic fibro-inflammation and fat. Using AI to delineate the liver and calculate regional volumes saves over 20 minutes of pre-operative radiology time per case.

Initial results from UK-based study on 143 surgical candidates showed that by combining estimated future liver remnant with an assessment of underlying fibro-inflammation, Hepatica could effectively identify patients at risk of poor outcomes from surgery and a longer stay in hospital. This information enables tumour boards and multidisciplinary teams to make more informed pre-operative decisions to improve post-operative outcomes for patients, translating to cost-savings in associated care.

Mr Myrddin Rees, Consultant General and Hepatobiliary Surgeon at HHFT commented, As a hepato-biliary surgeon with over 30 years of experience operating on the liver I am thrilled that Hepatica is now cleared for clinical use. The missing element in all our current diagnostic, non-invasive imaging is an accurate assessment of the quality of the liver parenchyma. Hepatica provides the surgeon with a measure of liver well-being that allows us to push the boundaries on the one hand whilst avoiding the removal of inappropriate liver volume on the other. This work is a significant advance in our quest to treat more patients with liver disease whilst armed with the knowledge of what can be achieved safely.

Hepatica seamlessly integrates into the clinical workflow and provides a simple, patient-friendly report via a cloud-based service.

Hepatica is an advanced oncology tool that provides objective information to guide personalized clinical management, said Professor Claude Sirlin, Professor of Radiology at University of California, San Diego. It is an excellent application of smart imaging and Artificial Intelligence in medicine, and I look forward to seeing how it can be used in a variety of indications to improve clinical care.

Notes to Editors

About Hepatica

Hepatica is a precision oncology tool for clinical and surgical decision support tool based on non-invasive quantitative multiparametric MRI. It identifies high risk patients and enables more informed preoperative decision making, therefore improving post-operative outcomes. Hepatica has demonstrated utility in identifying patients at risk of poor outcomes, with the potential to inform surgical planning and realize significant cost savings through lowering the post-surgical complication rate, associated in-patient hospital stay and reducing time required from radiologists.

About Perspectum

Perspectum delivers cutting-edge digital technologies that help clinicians provide better care for patients with liver disease, diabetes and cancer. With a strong focus on precision medicine using advanced imaging and genetics, our vision is to empower patients and clinicians through quantitative assessments of health enabling early detection, diagnosis, and targeted treatment. With a diverse team of physicians, biomedical scientists, engineers and technologists, Perspectum offers a way to manage complex health problems at scale. For more information, visit perspectum.com.

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Biotechnology research and policy expert joins Thunderbird School of Global Management and Sandra Day O’Connor College of Law at ASU through World…

Sunday, January 31st, 2021

Doxzen's two-year joint appointment is part of a cutting-edge collaboration between WEF's Centre for the Fourth Industrial Revolution (C4IR) in San Francisco and the two schools based on ASU's Downtown Phoenix campus. As a Hoffmann Fellow, Doxzen will lead transnational projects that explore and tackle global policy and governance challenges in healthcare driven by emerging biotechnologies such as gene editing and synthetic biology.

"We're thrilled to have Kevin in this high-impact role, which gives us an opportunity to re-imagine precision medicine by leveraging new biotech in developing countries in spite of low-resource challenges," said Thunderbird's Director General and Dean, Sanjeev Khagram.

"Kevin's experience and expertise in genome-editing research and policy position him to be a difference-maker on a global scale through this prestigious fellowship. Working with faculty, administrators, and professionals spanning the worldwide networks of Thunderbird, ASU Law, and WEF, he will advance scholarship and experimentation in an international community to create resilient, robust governance frameworks that guide emerging biotechnologies such as CRISPR for the benefit of humanity," said Khagram.

"ASU Law, through its Center for Law, Science and Innovation, and Thunderbird have a long history of working with WEF at the intersection of law, governance and emerging technologies," said ASU Law's Associate Dean for International Engagement Di Bowman. "Partnering with WEF's C4IR to host esteemed Hoffmann Fellows represents a new and exciting chapter in our collaboration and we are delighted to welcome Kevin as our first fellow."

"Global healthcare challenges depend on global solutions that harness scientific and technological advances from diverse sectors and disciplines," said Genya Dana, Head of Healthcare Transformation at the World Economic Forum. "We are excited to welcome Kevin to the Forum's C4IR to help us lead efforts to ensure that emerging biotechnologies support equitable and ethical health and healthcare advances. We look forward to this collaboration withleading-edge partners at ASU to design and pilot new business models, policies and collaborative approaches to supporting the translation of cutting-edge science into treating and even curing rare diseases, blood disorders, and cancers."

"The Coronavirus Pandemic and the new era of biotechnology associated with the Fourth Industrial Revolution that COVID-19 is accelerating highlight the vital importance of the work Kevin has already started," said Professor Landry Sign, search committee chair and Senior Director of Thunderbird's Fourth Industrial Revolution and Globalization 4.0 Center. "And as a Hoffmann Fellow at ASU, he'll continue tapping into a global spectrum of experts to advance both practice and policy in next-generation precision medicine, producing new knowledge and high-tech healthcare tools with real-world impact."

About Thunderbird School of Global ManagementThunderbird School of Global Management is a unit of the Arizona State University Enterprise. For 75 years, Thunderbird has been the vanguard of global management and leadership education, creating inclusive and sustainable prosperity worldwide by educating future-ready global leaders capable of tackling the world's greatest challenges. Thunderbird's Master of Global Management was ranked #1 in the world for 2019 by the Wall Street Journal/Times Higher Education. ASU is ranked No. 1 "Most Innovative School" in the nation by U.S. News & World Report for six years in succession. Thunderbird Executive Education has been ranked in the top 10 internationally for decades.

About the Sandra Day O'Connor College of LawThe Sandra Day O'Connor College of Law at Arizona State University is one of the nation's preeminent law schools, focused on offering students a personalized legal education. Ranked No. 1 in Arizona since 2010 and No. 24 nationally by U.S. News & World Report, ASU Law offers students the opportunity to tailor their education, to match externships to their interests and career services resources to help land their ideal jobs. Additionally, ASU Law's LEED Gold certified building in downtown Phoenix is steps away from the legal, political and economic heart of Arizona. For more information, visit law.asu.edu.

About ASUArizona State University has developed a new model for the American Research University, creating an institution that is committed to access, excellence, and impact. ASU measures itself by those it includes, not by those it excludes. As the prototype for a New American University, ASU pursues research that contributes to the public good, and ASU assumes major responsibility for the economic, social, and cultural vitality of the communities that surround it.

CONTACT:Jonathan Ward Thunderbird Media Relations[emailprotected]+1 480.490.9773Download Media

SOURCE Thunderbird School of Global Management

https://thunderbird.asu.edu/

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Personalized Medicines Market 2020- Applications, Challenges, Growth, Shares, Trends, Top Players and Forecast to 2026 with key players position (3G…

Sunday, January 31st, 2021

The Personalized Medicines Market grew in 2019, as compared to 2018, according to our report, Personalized Medicines Market is likely to have subdued growth in 2020 due to weak demand on account of reduced industry spending post Covid-19 outbreak. Further, Personalized Medicines Market will begin picking up momentum gradually from 2021 onwards and grow at a healthy CAGR between 2021-2025.

Deep analysis about Personalized Medicines Market status (2016-2019), competition pattern, advantages and disadvantages of products, industry development trends (2019-2025), regional industrial layout characteristics and macroeconomic policies, industrial policy has also been included. From raw materials to downstream buyers of this industry have been analysed scientifically. This report will help you to establish comprehensive overview of the Personalized Medicines Market

Get a Sample Copy of the Report at: https://i2iresearch.com/download-sample/?id=16521

The Personalized Medicines Market is analysed based on product types, major applications and key players

Key product type:PM DiagnosticsPM TherapeuticsPersonalized Medical CarePersonalized Nutrition & Wellness

Key applications:Hospitals PharmaciesRetail PharmaciesDietary Care CentersOthers

Key players or companies covered are:3G BiotechQuest DiagnosticsLaboratory Corporation of AmericaAbbottAgendia NVAsuragen IncBecton DickinsonCardioDx Inc.Foundation MedicineQiagenSiemens HealthcareAmgenBristol-Myers SquibbGE HealthcarePfizerSanofi23andMeIllumina

The report provides analysis & data at a regional level (North America, Europe, Asia Pacific, Middle East & Africa , Rest of the world) & Country level (13 key countries The U.S, Canada, Germany, France, UK, Italy, China, Japan, India, Middle East, Africa, South America)

Inquire or share your questions, if any: https://i2iresearch.com/need-customization/?id=16521

Key questions answered in the report:1. What is the current size of the Personalized Medicines Market, at a global, regional & country level?2. How is the market segmented, who are the key end user segments?3. What are the key drivers, challenges & trends that is likely to impact businesses in the Personalized Medicines Market?4. What is the likely market forecast & how will be Personalized Medicines Market impacted?5. What is the competitive landscape, who are the key players?6. What are some of the recent M&A, PE / VC deals that have happened in the Personalized Medicines Market?

The report also analysis the impact of COVID 19 based on a scenario-based modelling. This provides a clear view of how has COVID impacted the growth cycle & when is the likely recovery of the industry is expected to pre-covid levels.

Contact us:i2iResearch info to intelligenceLocational Office: *India, *United States, *GermanyEmail: [emailprotected]Toll-free: +1-800-419-8865 | Phone: +91 98801 53667

https://neighborwebsj.com/

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Global Companion Diagnostics Market Growth, Trends, and Forecasts Report 2020-2025: Companies Promoting Personalized Medicine and Targeted Therapy as…

Saturday, January 2nd, 2021

Dublin, Dec. 30, 2020 (GLOBE NEWSWIRE) -- The "Companion Diagnostics Market - Growth, Trends, and Forecasts (2020 - 2025)" report has been added to ResearchAndMarkets.com's offering.

The growth of the global companion diagnostics market can be attributed to the rising focus on personalized medicine and the co-development of drug and diagnostic technologies. Additionally, rising cases of adverse drug reactions related to drugs, due to the lack of efficacy, drive the need for companion diagnostics.

One of the major factors driving the growth of the companion diagnostics market is the increasing demand for personalized medicines and awareness about the same, among the population. With companies increasing their collaborations for better biomarkers and diagnostics, in order to focus on cost regulations, there has been a significant number of opportunities for its applications in indications, like cancer, cardiovascular, and neurological disorders.

Key Market Trends

Application in Lung Cancer is expected to Dominate the Market over the Forecast Period

Companion diagnostic tests (CDXs) are considered mandatory in decision-making for treatment with targeted therapies in lung cancer. The emergence of immunotherapy has also given rise to the development of CDXs. Therascreen EGFR RGQ PCR Kit (Qiagen) and Cobas EGFR Mutation Test v2 (Roche Molecular Systems) are some of the many companion diagnostics available for lung cancer therapies.

Moreover, lung cancer is the most common form of cancer, and causes most cancer-related deaths, globally, as per the 2018 report by the World Health Organization. This translates to more demand for lung cancer companion diagnostics, which is expected to help the market growth.

North America Captured the Largest Market Share and is Expected to Retain its Dominance

North America dominated the overall companion diagnostics market, with the United States emerging as the major contributor to the market. The use of companion diagnostics is considered as an important treatment decision tool for a number of oncology drugs, which is also reflected in the way the FDA classifies these assays, in relation to risk.

In the United States, companion diagnostic assays are classified as IVD class III products, which represents a high-risk category, and consequently, the highest level of regulatory control. Hence, owing to high healthcare technology adoption rates and increasing demand for personalized medicine, the US companion diagnostics market is expected to register a substantial growth rate, during the forecast period.

Competitive Landscape

The presence of major market players, such as Abbott Laboratories, Agilent Technologies Inc., F Hoffmann-La Roche Ltd, Biomerieux SA, and Qiagen NV, is increasing the overall competitive rivalry of the market studied.

However, the issues associated with the high development cost and poor reimbursement are affecting the market negatively. Moreover, the rising focus of companies toward personalized medicine, co-development activities, and increased cases of adverse drug reactions is expected to boost the competitive rivalry in the market studied.

Key Topics Covered:

1 INTRODUCTION1.1 Study Deliverables1.2 Study Assumptions1.3 Scope of the Study

2 RESEARCH METHODOLOGY

3 EXECUTIVE SUMMARY

4 MARKET DYNAMICS4.1 Market Overview4.2 Market Drivers4.2.1 Companies Promoting Personalized Medicine and Targeted Therapy as a New Treatment Option4.2.2 Increasing Cases of Adverse Drug Reactions4.2.3 Co-development of Drug and Diagnostic Technology4.3 Market Restraints4.3.1 High Cost of Drug Development and Associated Clinical Trials4.3.2 Reimbursement Issues among Many Countries4.4 Industry Attractiveness - Porter's Five Forces Analysis

5 MARKET SEGMENTATION5.1 By Technology5.1.1 Immunohistochemistry (IHC)5.1.2 Polymerase Chain Reaction (PCR)5.1.3 In-situ Hybridization (ISH)5.1.4 Real-time PCR (RT-PCR)5.1.5 Gene Sequencing5.1.6 Other Technologies5.2 By Indication5.2.1 Lung Cancer5.2.2 Breast Cancer5.2.3 Colorectal Cancer5.2.4 Leukemia5.2.5 Melanoma5.2.6 Other Indications5.3 By Geography

6 COMPETITIVE LANDSCAPE6.1 Company Profiles6.1.1 Abbott Laboratories6.1.2 Agilent Technologies Inc.6.1.3 F Hoffmann-La Roche Ltd6.1.4 Biomerieux SA6.1.5 Qiagen NV6.1.6 Siemens Healthcare6.1.7 Thermo Fisher Scientific Inc.6.1.8 Danaher Corporation (Beckman Coulter Inc.)

7 MARKET OPPORTUNITIES AND FUTURE TRENDS

For more information about this report visit https://www.researchandmarkets.com/r/7z4nt2

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Global Research Antibodies and Reagents Market Report 2020-2027: Significant Opportunities from Emerging Asia-Pacific and Latin-American Markets -…

Saturday, January 2nd, 2021

Dublin, Dec. 31, 2020 (GLOBE NEWSWIRE) -- The "Research Antibodies and Reagents Market by Product {Antibodies [Type (Primary, Secondary), Production, Source, Research Area (Oncology, Neurology)], Reagents}, Technology (ELISA, Western Blot), Application, End User (Pharma, Academia) - Global Forecast to 2027." report has been added to ResearchAndMarkets.com's offering.

The research antibodies and reagents market is expected to grow at a CAGR of 5.6% from 2020 to 2027 to reach USD 6.32 billion by 2027.

Factors such as rising demand for protein therapeutics & personalized medicine, increasing investment in stem cell research, and rising need for biomarker identification represent high-growth opportunities for players during the forecast period. However, factors such as high cost and time related to identifying and developing potential antibodies are expected to hinder the growth of this market.

In 2020, based on type, the antibodies segment is projected to account for the largest share of this market. The large share of this segment is mainly attributed to increasing demand for antibodies for biomedical research, growing focus on protein and cell-based research, and increasing number of biomarker discovery.

On the basis of technology, in 2020, the flow cytometry segment is poised to command the largest share of the research antibodies and reagents market. The raising biomedical research for better diagnosis and therapy, initiatives for rising biomarker discovery, and growing cell & molecular-based research are the factors driving this growth of this segment.

In 2020, the proteomics segment is expected to command the largest share of the research antibodies and reagents market. Growing focus on protein-based research and the rising need for effective drugs using various protein-based disease profiling are the factors driving the growth of this segment.

The pharmaceutical and biotechnology industry is widely adopting research antibodies and reagents for proteomics research and drug discovery and development.

An in-depth analysis of the geographical scenario of the research antibodies and reagents market provides detailed qualitative and quantitative insights for the five major geographies (North America, Europe, Asia-Pacific, Latin America, and the Middle East & Africa) along with the coverage of major countries in each region. In 2020, North America is estimated to command the largest share of the research antibodies and reagents market, followed by Europe, Asia-Pacific, Latin America, and the Middle East & Africa.

Key Topics Covered:

1. Introduction1.1. Market Ecosystem1.1.1. Research Antibodies and Reagents Market1.1.2. Research Antibodies and Reagents Market, by Product1.2. Currency and Limitations1.3. Key Stakeholders

2. Research Methodology2.1. Research Process2.1.1. Secondary Research2.1.2. Primary Research

3. Executive Summary

4. Market insights4.1. Introduction4.2. Market Dynamics4.2.1. Drivers4.2.1.1. Rising Proteomics and Genomics Research Studies4.2.1.2. Increase in the Funding for Research Activities4.2.1.3. Growing Industry-Academia Collaboration4.2.2. Restraint4.2.2.1. High Cost and Time Related to Identification and Development of Potential Antibodies4.2.3. Opportunities4.2.3.1. Rising Demand for Protein Therapeutics and Personalized Medicines4.2.3.2. Rising Investment and Focus on Stem-Cell Research4.2.3.3. Rising Need for New Biomarker Identification4.2.3.4. Significant Opportunities from Emerging Asia-Pacific and Latin-American Markets4.2.4. Challenges4.2.4.1. Issues Related to Quality and Stability of Research Antibodies4.2.4.2. Intense Pricing Pressure on Leading Players

5. Research Antibodies and Reagents Market, by Product5.1. Introduction5.2. Antibodies5.2.1. Antibodies Market, by Type5.2.1.1. Primary Antibodies5.2.1.2. Secondary Antibody5.2.2. Antibodies Market, by Production Type5.2.2.1. Monoclonal Antibody5.2.2.2. Polyclonal Antibody5.2.2.3. Antibody Fragments5.2.3. Antibody Market, by Source5.2.3.1. Mouse5.2.3.2. Rabbit5.2.3.3. Other Sources5.2.4. Antibodies Market, by Research Area5.2.4.1. Oncology5.2.4.2. Infectious Diseases5.2.4.3. Cardiovascular Disease5.2.4.4. Immunology5.2.4.5. Neurology5.2.4.6. Stem Cell Research5.2.4.7. Other Research Areas5.3. Reagents5.3.1. Sample Preparation Reagents5.3.1.1. Media and Serum5.3.1.2. Stains and Dyes5.3.1.3. Probes5.3.1.4. Buffers5.3.1.5. Solvents5.3.2. Antibody Production Reagents5.3.2.1. Enzymes5.3.2.2. Proteins5.3.3. Other Research Reagents

6. Research Antibodies and Reagents Market, by Technology6.1. Introduction6.2. Flow Cytometry6.3. Immunofluorescence6.4. Enzyme-Linked Immunosorbent Assay6.5. Immunoprecipitation (IP)6.6. Multiplex Immunosorbent Assay6.7. Immunohistochemistry6.8. Western Blot6.9. Other Technologies

7. Research Antibodies and Reagents Market, by Application7.1. Introduction7.2. Proteomics7.3. Drug Discovery and Development7.4. Genomics

8. Research Antibodies and Reagents Market, by End User8.1. Introduction8.2. Pharmaceutical and Biotechnology Industry8.3. Academic and Research Institutes8.4. Contract Research Organizations

9. Research Antibodies and Reagents Market, by Geography

10. Competitive Landscape10.1. Introduction10.2. Key Growth Strategies10.3. Competitive Benchmarking10.4. Market Share Analysis

11. Company Profiles11.1. Business Overview11.2. Financial Overview11.3. Product Portfolio

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USA Equities Corp (USAQ), Announces Revenues of $120000 for the 4th Quarter of 2020 and Projects Revenues in excess of $300000 for the 1st Quarter of…

Saturday, January 2nd, 2021

WEST PALM BEACH, FL, Dec. 30, 2020 (GLOBE NEWSWIRE) -- USA EQUITIES CORP. (OTCQB: USAQ) (the Company, we, or our) announced today that its revenues for the fourth quarter of 2020 would be approximately $120,000 and that its revenues would exceed $300,000 in the first quarter of 2021.

We introduced our QHSLab, Software as a Service (SaaS) platform, to 159 medical practices in June 2020. Through September, physicians in these practices provided 374 allergy patients with a QHSLab-generated allergen immunotherapy prescription, generating an estimated $664,608 in revenue for these physicians practices. In November, building on the capabilities of our QHSLab, we began shipping allergy diagnostic related products and immunotherapy treatments to these physicians in response to their requests based upon courses of treatment recommended for their patients by QHSLab. Our revenue in the fourth quarter will be $120,000 as a result of these sales. Based upon orders in hand and reasonably anticipated, revenues from our allergy diagnostic test kits and treatment programs should exceed $300,000 in the first quarter of 2021. Revenues from this program should continue to increase thereafter as we increase the number of physicians and medical practices utilizing QHSLab.

Based on our QHSLab allergy treatment systems success, we intend to increase our revenues by charging physicians a monthly subscription fee for the use of QHSLab. USAQ plans to introduce these physicians to additional point of care diagnostic, digital medicine, and treatments that our physician clients can use and prescribe. They will be paid under existing government and private insurance programs, based upon analyses conducted utilizing QHSLab.

The revenues we generated in the fourth quarter of 2020 and anticipated revenue in the first quarter of 2021 far exceed the revenue levels assumed by the equity research firm, Litchfield Hills Research, when it released its first analyst coverage report on USAQ. Litchfield Hills continue to rate our stock as a buy under its three-tiered rating system, with a target price of $5.00 per share.

About USA Equities Corp (OTCQB: USAQ)

On December 20, 2019 USA Equities Corp completed a share exchange whereby it acquired Medical Practice Income, Inc. (MPI). The Company is focused on value-based healthcare solutions, clinical informatics and algorithmic personalized medicine including digital therapeutics, behavior based remote patient monitoring, chronic care and preventive medicine. The Companys products are intended to allow the general practice physician to increase his revenues by cost effectively diagnosing and treating chronic diseases generally referred to specialists. The Companys products and information service portfolio are directed towards prevention, early detection, management, and reversal of cardio-metabolic and other chronic diseases. Our principal objectives are to develop proprietary software tools, devices, and approaches, providing more granular, timely, and specific clinical decision-making information for practicing physicians and other health care providers to address todays obese, diabetic and cardiovascular disease population. The Company is located in West Palm Beach, Florida. For more information, visit http://www.MedicalPracticeIncome.com/discover.

Forward-Looking Statements

Certain matters discussed in this press release are 'forward-looking statements' intended to qualify for the safe harbor from liability established by the Private Securities Litigation Reform Act of 1995. In particular, the Company's statements regarding trends in the marketplace, future revenues, future products and potential future results and acquisitions, are examples of such forward-looking statements. Forward-looking statements are generally identified by words such as may, could, believes, estimates, targets, expects, or intends and other similar words that express risks and uncertainties. These statements are subject to numerous risks and uncertainties, including, but not limited to, the timing of the introduction of new products, the inherent discrepancy in actual results from estimates, projections and forecasts made by management, regulatory delays, changes in government funding and budgets, and other factors, including general economic conditions, not within the Company's control. The factors discussed herein and expressed from time to time in the Company's filings with the Securities and Exchange Commission could cause actual results and developments to be materially different from those expressed in or implied by such statements. The forward-looking statements are made only as of the date of this press release and the Company undertakes no obligation to publicly update such forward-looking statements to reflect subsequent events or circumstances.

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Revisiting Late-Onset Asthma: Clinical Characteristics and Association | JAA – Dove Medical Press

Saturday, January 2nd, 2021

Santiago Quirce,1 Enrico Heffler,2 Natalia Nenasheva,3 Pascal Demoly,4 Andrew Menzies-Gow,5 Ana Moreira-Jorge,6 Francis Nissen,7 Nicola A Hanania8

1Department of Allergy, La Paz University Hospital, IdiPAZ and Universidad Autnoma de Madrid, Madrid, Spain; 2Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, MI, Italy; 3Department of Allergology and Immunology of Russian Medical Academy for Continuous Medical Education, Moscow, Russian Federation; 4Department of Pulmonology, Division of Allergy, Hpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France; 5Department of Respiratory Medicine, Royal Brompton Hospital, London, UK; 6Novartis Farmaceutica, S.A., Barcelona, Spain; 7London School of Hygiene and Tropical Medicine, London, UK; 8Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA

Correspondence: Santiago QuirceHospital Universitario La Paz, P. La Castellana, 261, Madrid, 28046 SpainEmail squirce@gmail.com

Abstract: The Global Initiative for Asthma (GINA) 2020 defines late-onset asthma (LOA) as one of the clinical phenotypes of asthma wherein patients, particularly women, present with asthma for the first time in adult life, tend to be non-allergic and often require higher doses of inhaled corticosteroids (ICS) or are relatively refractory to corticosteroid treatment. In this review, we examine the published literature improve the understanding of the following aspects of LOA: 1) the age cut-off for its diagnosis; 2) its distinct clinical phenotypes, characteristics and risk factors; and 3) its association with allergic comorbidities and conditions. Overall, our review reveals that clinicians and researchers have used multiple age cut-offs to define LOA, with cut-off ages ranging from > 12 years to 65 years. LOA has also been classified into several distinct phenotypes, some of which drastically differ in their clinical characteristics, course and prognosis. Although LOA has traditionally been considered non-allergic in nature, our review indicates that it is commonly associated with allergic features and comorbidities. Our findings suggest that there is an urgent need for the development of more clear clinical practice guidelines that can provide more clarity on the definition and other aspects of LOA. In addition, the association of LOA and allergy needs to be re-examined to frame a more optimal treatment strategy for patients with LOA.

Keywords: asthma, diagnosis, age of onset, allergy, allergic asthma, asthma phenotypes

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Creative Medical Technology Holdings Announces Reversion of Liver Failure Using ImmCelz Personalized Cellular Immunotherapy in Preclinical Model -…

Saturday, January 2nd, 2021

PHOENIX, Dec. 29, 2020 /PRNewswire/ --(OTC-CELZ)Creative Medical Technology Holdings Inc. announced today novel data and patent filing No. 63131261 describing the ability of ImmCelz to reverse liver failure in the carbon tetrachloride preclinical model of hepatocyte necrosis.

These findings are the basis for a patent filing covering various means of generating the ImmCelz product in a hepatoprotective specific manner. The Company has previously reported that ImmCelz is capable of treating animal models of stroke,1 as well as inducing "immunological tolerance" in a model of autoimmune rheumatoid arthritis.2

The work is an extension of previously published findings of Dr. Thomas E. Ichim, in which mesenchymal stem cells were capable of inhibiting progression of liver failure.3

"I am proud of the work the team at Creative Medical Technologies is conducting in advancing the concept of immunologically-mediated regeneration,"said Dr. Ichim, Co-inventor of the patent. "ImmCelz is an advancement on our previous liver failure work due to the fact that we have shown transfer of regenerative activity from the stem cell to the immune cell. Immune cells possess ability to home to injured tissues faster than stem cells due to their smaller size. Additionally, immune cells possess immunological memory, which we believe may be applied to the concept of regeneration."

"While stem cell therapeutics are recognized as the future of medicine, I believe it is important to realize that many activities of stem cells are mediated by changes to the immune system," said Dr. Amit Patel, Board Member of the Company and Co-Inventor of the Patent Application. "ImmCelz represents a fundamental advancement in regenerative medicine in that instead of administering stem cells in the body to induce immune modulation, we actually optimize the immune modulation in the laboratory before injecting immune cells into the patient."

Being at the forefront in identifying novel regenerative treatment options, the Company possesses numerous issued patents in the area of cellular therapy, including patent no. 10,842,815 covering use of T regulatory cells for spinal disc regeneration, patent no. 9,598,673 covering stem cell therapy for disc regeneration, patent no. 10,792,310 covering regeneration of ovaries using endothelial progenitor cells and mesenchymal stem cells, patent no. 8,372,797 covering use of stem cells for erectile dysfunction, and patent no. 7,569,385 licensed from the University of California covering a novel stem cell type.

"Liver failure represents a significant unmet medical need and I am extremely excited that ImmCelz has the potential to help the numerous patients on the liver transplant waiting list who currently have no other option.

With growing validation and acceptance of such technologies, the company intends to continue to broaden its intellectual property portfolio by compiling research data and filing patents, in order to record early filing dates and increase the likelihood of our receiving patent issue.

We continue to welcome opportunities with collaborators and Key Opinion Leaders as we are dedicated to accelerating the further development of our technology."

About Creative Medical Technology Holdings

Creative Medical Technology Holdings, Inc. is a commercial stage biotechnology company specializing in stem cell technology in the fields of urology, neurology and orthopedics and trades on the OTC under the ticker symbol CELZ. For further information about the company, please visitwww.creativemedicaltechnology.com.

Forward Looking Statements

OTC Markets has not reviewed and does not accept responsibility for the adequacy or accuracy of this release. This news release may contain forward-looking statements including but not limited to comments regarding the timing and content of upcoming clinical trials and laboratory results, marketing efforts, funding, etc. Forward-looking statements address future events and conditions and, therefore, involve inherent risks and uncertainties. Actual results may differ materially from those currently anticipated in such statements. See the periodic and other reports filed by Creative Medical Technology Holdings, Inc. with the Securities and Exchange Commission and available on the Commission's website atwww.sec.gov.

Creativemedicaltechnology.comwww.StemSpine.comwww.Caverstem.comwww.Femcelz.com

1 Creative Medical Technology Holdings Identifies Mechanism of Action of ImmCelz Stroke Regenerative Activity (prnewswire.com)2 Creative Medical Technology Holdings Reports Positive Preclinical Data on ImmCelz Immunotherapy Product in Rheumatoid Arthritis Model | BioSpace 3 Human endometrial regenerative cells alleviate carbon tetrachloride-induced acute liver injury in mice | Journal of Translational Medicine | Full Text (biomedcentral.com)

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The technological transformations that marked 2020 – Mint

Saturday, January 2nd, 2021

On 1 January 2020, I published my very first Ex Machina article of the year. Since it was also the beginning of a new decade, I made my own modest attempt at predicting the technological changes we could hope to expect in the coming years. I wrote about the promise of artificial intelligence, speech recognition and augmented reality, and how they would come together to let us speak to computers in novel ways. I argued that technology would transform our commute, eventually leading to a future of shared autonomous vehicles that would completely eliminate the need to own personal cars, etc. Finally, I spoke of personalized medicine and a future in which treatments could be calibrated to individual requirements, instead of being focused on discovering drugs that need to work on the entire human population.

What I did not predict was that in a couple of months, a global pandemic would bring the entire world to a grinding halt.

Much of what I had thought would happen will likely still come to passalthough in a slightly different way from what I had imagined. Now that companies have realized how easy it is to support working from home, many businesses are re-thinking their investments in commercial real estatecommitting themselves instead to enabling employees to work from wherever they might be at a given point in time.

In addition to all that I had anticipated, I believe this new mindset will eventually contribute to a fundamental alteration of our commute and be another catalyst for some of the urban mobility solutions. I had anticipated. And while autonomous transportation may not become a reality anytime soon, I am excited by the immediate promise that platform solutions of the likes of Beckn have to offer.

I had suggested in my article that computers might soon be able to speak coherently with us, but even I did not imagine wed get there so soon. The remarkable language abilities of OpenAIs Generative Pre-trained Transformer Ver 3 (GPT-3) technology took the world by storm this year. But while initial reports suggested that it would make computer communications indistinguishable from human speech, closer study revealed flaws in its output, as also practical limitations in working with very large data-sets. That said, I was heartened by the emergence of new techniques of artificial intelligence such as few-shot learning, and the promise that it could hold for data-starved countries like India.

But the technology breakthrough that everyone was focused on for all of 2020 was in medicine. On this front, my prediction at the beginning of the year fell well short of the mark. As hopeful as I still am for a future in which medicine will be personalized, the covid pandemic made it clear that there will always be a need for medical solutions that can be rolled out rapidly and at scale to the entire global population.

I am thankful that our investments in genetic technologies, the global interconnectedness of the scientific community and the manufacturing capabilities of pharmaceutical companies came together so well this past year to enable us to produce multiple vaccines for covid-19 in record time. I hope these demonstrations of success encourage us to invest in platform vaccine technologies, so that we are better placed to deal with such challenges that we will, no doubt, continue to face in the future.

But, more than anything else, the pandemic demonstrated the central role that technology now plays in society. From the contact-tracing apps that were all the rage in the early months of the diseases outbreak, to the remote-working solutions that brought us together even though we were far apart, it is clear that all aspect of our lives today are dependent on technology.

Our recent experiences will hopefully serve as the impetus we need to make sure that small businesses and ordinary citizens in this country get greater access to the internet, so that they can all partake in this future.

Early in the lockdown, the department of telecommunications relaxed the work-from-home restrictions that applied to technology companies registered as Other Service Providers (OSP)a relaxation that was made permanent before the end of the year with a radical overhaul of the entire OSP framework. Later in the year, the Union cabinet approved the Prime Minister Wi-Fi Access Network Interface, or PM Wani , a new regulation system for wifi that will encourage the rapid proliferation of digital technologies in India.

As good as these regulatory measures might be, we still need key technology legislation to bring us on par with the rest of the world. It was good to see that despite the constraints imposed by the pandemic, the meetings of the Joint Parliamentary Committee on data protection proceeded apace. Equally interesting was the governments interest in regulating non-personal data, making India the first country to attempt governing the entire data landscape.

As gruesome as the year has been, it has forced us to reconsider our relationship with technologyand to engage with it in different ways.

Rahul Matthan is a partner at Trilegal and also has a podcast by the name Ex Machina. His Twitter handle is @matthan

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Predictive Oncology Announces Cancellation of Special Meeting in December 2020Reincorporation Proposal Received Overwhelming Support Among Shares…

Saturday, January 2nd, 2021

NEW YORK, Dec. 29, 2020 (GLOBE NEWSWIRE) -- Predictive Oncology (NASDAQ: POAI) (the Company), a knowledge-driven company focused on applying artificial intelligence (AI) to personalized medicine and drug discovery, today announced that its Board of Directors has decided to cancel its Special Meeting of Stockholders that was originally scheduled for December 1, 2020. On that date, the meeting was adjourned to December 30, 2020 because a quorum was not reached. As of December 30, 2020, approximately 47% of the outstanding shares as of the record date have been voted, and therefore a quorum has still not been reached. The Board of Directors has determined that it is not practical to incur the expense of adjourning the meeting further to continue to solicit proxies, because approval of the reincorporation proposal would require the affirmative vote of a majority of the Companys outstanding shares (not simply a majority of the shares voted).

The Board notes that, of the shares that were voted at the Special Meeting, nearly 88% of the shares were voted FOR the reincorporation from Delaware to Nevada. In the future, the Board intends to continue to seek stockholder approval for reincorporation, due in part to the oppressive franchise taxes charged by Delaware.

About Predictive Oncology Inc.

Predictive Oncology (NASDAQ: POAI) operates through three segments (Skyline, Helomics and Soluble Biotech), which contain four subsidiaries: Helomics, TumorGenesis, Skyline Medical and Soluble Biotech.

Helomics applies artificial intelligence to its rich data gathered from patient tumors to both personalize cancer therapies for patients and drive the development of new targeted therapies in collaborations with pharmaceutical companies. TumorGenesis Inc. specializes in media that help cancer cells grow and retain their DNA/RNA and proteomic signatures, providing researchers with a tool to expand and study cancer cell types found in tumors of the blood and organ systems of all mammals, including humans. Skyline Medical markets its patented and FDA cleared STREAMWAY System, which automates the collection, measurement and disposal of waste fluid, including blood, irrigation fluid and others, within a medical facility, through both domestic and international divisions. Soluble Biotech is a provider of soluble and stable formulations for proteins including vaccines, antibodies, large and small proteins and protein complexes.

Forward-Looking Statements

Certain matters discussed in this release contain forward-looking statements. These forward-looking statements reflect our current expectations and projections about future events and are subject to substantial risks, uncertainties and assumptions about our operations and the investments we make. All statements, other than statements of historical facts, included in this press release regarding our strategy, future operations, future financial position, future revenue and financial performance, projected costs, prospects, plans and objectives of management are forward-looking statements. The words anticipate, believe, estimate, expect, intend, may, plan, would, target and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Our actual future performance may materially differ from that contemplated by the forward-looking statements as a result of a variety of factors including, among other things, factors discussed under the heading Risk Factors in our filings with the SEC. Except as expressly required by law, the Company disclaims any intent or obligation to update these forward-looking statements.

Investor Relations Contact:

Hayden IRJames Carbonara(646)-755-7412

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Worldwide Industry for Microbiome Sequencing Services to 2025 – Increased Focus on Human Microbiome Therapy is Driving Growth – ResearchAndMarkets.com…

Saturday, January 2nd, 2021

The "Global Microbiome Sequencing Services Market (2020-2025) by Technology, Application, Research Type, Laboratory Type, End-Users, Geography and the Impact of Covid-19 with Ansoff Analysis" report has been added to ResearchAndMarkets.com's offering.

The Global Microbiome Sequencing Services Market is estimated to be USD 1.02 billion in 2020 and is expected to reach USD 2.31 billion by 2025, growing at a CAGR of 17.8%.

Microbiomes are a group of micro-organisms living on a human body. They live on the skin, eyes, saliva, mouth, and the gastrointestinal tract. The human microbiome contains thousands of bacterial species/microbes in diverse communities, along with their genes, proteins, and metabolites. An imbalance of these microbes can lead to life-threatening diseases. The study of Microbiome sequencing and its techniques relates to the study of the microbial composition of the human gut and to understand the resulting impact on health and disease development.

Microbiome sequencing is usually done to understand this microflora residing on the human body and further study human microbes and their role in related diseases. This study can also be helpful while analyzing the patient's response to a particular treatment. Effective understanding and application of microbiome sequencing services would help in the commercialization of personalized medicine and diet. Hence, the market is extensively driven by research-based communities, especially in the developed economies like the US, which has the presence of NHGRI (National Human Genome Research Institute) supporting the growth of the market.

Due to advancements in technology, there has been a rise in the NGS (Next-Gen Sequencing) to generate microbiome data. Besides, techniques such as novel high-throughput sequencing and new software tools are transforming microbiome studies by providing service at high quality, speed, and high cost. Many companies are additionally concentrating on novel exome sequencing and RNA sequencing applications in niche market segments.

Story continues

Specific factors that have led to the growth of this market are the rising use of microbiome in genomics, along with the reduced cost of sequencing. However, other factors such as the lack of expertise in the data analysis for the microbiomes with advanced tools shall hinder the growth of this market.

Market Dynamics

Drivers

Increased Focus on Human Microbiome Therapy

Reduction in the Cost of Sequencing

Human Microbiome as a New Validated Target for Drug Development

Human Microbiome Used as an Aid for Early Disease Detection and Diagnosis

Increasing Demand for NGS

Restraints

Lack of Skilled Professionals for Microbiome Sequencing Services

Lack of Awareness Among Physicians and Scientist about Advanced Tools for Data Analysis

Barriers in Proving the Causal Link Between Dysbiosis and Disease

Opportunities

Investigational New Drug (IND) Requirements for Fecal Microbiota

Increasing Collaborations Create Growth Opportunities

Increasing Research Investments and Technological Advancements

Why Buy this report?

The report offers a comprehensive evaluation of the Global Microbiome Sequencing Services Market. - The report includes in-depth qualitative analysis, verifiable data from authentic sources and projections about market size. The projections are calculated using proven research methodologies.

The report has been compiled through extensive primary and secondary research. The primary research is done through interviews, surveys and observation of renowned personnel in the industry.

The report includes in-depth market analysis using Porter's 5 force model and the Ansoff Matrix. The impact of Covid-19 on the market is also featured in the report.

The report also contains a competitive analysis using IGR Positioning Quadrants, Infogence's Proprietary competitive positioning tool.

Companies Mentioned

Baseclear B.V.

Clinical-Microbiomics A/S

Molzym GmbH & Co. Kg

Zymo Research Corp.

Rancho Biosciences

Microbiome Therapeutics, LLC.

Microbiome Insights Inc.

Openbiome

Resphera Biosciences, LLC.

MR DNA (Molecular Research LP)

Shanghai Realbio Technology Co., Ltd

Diversigen, Inc.

Merieux Nutrisciences Corporation

Metabiomics Corp.

Second Genome

LOCUS BIOSCIENCES, INC,

BioSpherex LLC

For more information about this report visit https://www.researchandmarkets.com/r/6xv3hj

View source version on businesswire.com: https://www.businesswire.com/news/home/20201229005159/en/

Contacts

ResearchAndMarkets.comLaura Wood, Senior Press Managerpress@researchandmarkets.com For E.S.T Office Hours Call 1-917-300-0470For U.S./CAN Toll Free Call 1-800-526-8630For GMT Office Hours Call +353-1-416-8900

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After accepting virtual trainers, AI-powered nutrition is the next step in keeping a healthy lifestyle – Geektime

Saturday, January 2nd, 2021

The day comes for all of us, and the day Im speaking of is that day when our once loose jeans and baggy shirt become a bit tighter around the waste. Its at that time we decide to get down to business, hit the gym, and skip the cookie aisle at the supermarket, because the diet starts now.

COVID hits and its not that easy to get our work out on. Still we wake every morning and go for a run, even buy weights, do the research and plan out are meals. After chugging down a protein shake, suddenly losing those extra pounds feels easy. However, then, with the runners high wearing off, a bag of Cheetos, a few beers, and more than one off-day later, and you realize that this is going to be an uphill battle.

Israeli startup Newt and its founder and CEO Gil Kerbs understand the struggle of maintaining a healthy diet and schedule. The company developed an AI-powered platform that uses your daily habits to generate a personalized regiment to keep your nutritional goals on track. Or as Gil puts it Our product interacts with users daily to understand and aggregate all information needed for health / nutrition based decisions, and then provides daily support to start shifting their behavior towards healthier habits.

With the year of COVID coming to a hopeful end, it was definitely a great year for remote technology, from medicine to fitness, the global pandemic did change the way people interact virtually. So how has personalized nutrition gained such popularity? GIl says that It's kind of the 'perfect storm'. We are so focused on our health and wellbeing due to the pandemic - we finally REALLY know that actively staying fit and healthy can help prevent harsh impacts from sickness, such as with COVID. We are also witnessing the rise of AI, allowing for true personalization - a personal fitness coach that is really 'personal', and now with Newt, a personal nutritionist that really tailors everything for you.

Gil explains that he sees preventative care as the future of personalized medicine, not only giving you the 'right' medicine when you need it but rather helping you make the right daily decisions that eventually shape your long term health.

Yeah, this is probably not the first fitness/nutrition app youve heard of, but Newt does things a little different, actually putting your habits in the center to better motivate you. But how is it done? In one word - "behavioral personalization". We are not aiming for a quick perfect, but for the closest to optimal that you can sustain for the long run. Our Behavioral expertise stretches from Prof. Adam Grant (Wharton, world leading motivation expert), and Stanford Mind&Body lab who focus on use of psychology for wellbeing. Our goal is to make not only the best clinical knowledge available, but rather to combine it with cutting edge psychology/behavior knowledge that makes behavior and diet change a real possibility in the long run."

Gils attachment to the subject comes from his years in the medical industry as part of Medtronic China, where he notes that it was very rewarding to help add 1-2 years to people's lives, but I wanted more - 20-30 more years, with better quality - and this could not be done when the patient is already in the OR. So, I got into preventative medicine, and there's nothing bigger for your long term health than your nutrition... All of us at Newt have this motivation - helping people keep healthy, by harnessing the strongest force available to everyone - daily nutrition."

He adds that although intervention healthcare isnt going anywhere and will maintain an important part of medical care but preventative can be better for humanity as a whole, Take cancer - surgery's solution is to take it out or 'kill it' (radiation), but not to solve what caused it, yet. This is a short term solution due to the limitations of our knowledge. Think about it this way - 5 year survival rates for various cancers are still very low, despite utilizing cutting edge technology to treat them. Preventative healthcare is much less 'high-tech', we don't need robots - nor huge amounts of dollars - it's rather cheap - and it really helps dramatically reduce chances of getting sick. The real problem is that it's a marathon, and not just a sprint intervention, making it psychologically harder. That's why we at Newt focus on behavior so much.

Founded in 2019, Newt has received backing from Welltech1 - a wellness microfund, and angel investors. And according to Gil, the company has a few partnerships in the works. Cool idea and all but why the name Newt? We wanted something short that sounds like nutrition, but is also a name of a character. We see Newt as a personal guide for nutrition. It's also a really cute animal, said Kerbs.

Ok, last thing, even though its been a weird year, were sure people will keep in the tradition of failing at their New Years resolutions (myself a victim), so we asked Gil to take from his nutritional expertise and offer some advice: ...In general I'd advise people that next time they 'fail' with a resolution, they should not beat themselves up about it, but rather think how to better approach it next time. Usually, there's a fun, easier way to achieve success and give you great results in the long run.

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Predictions for AI-powered digital healthcare in 2021 – MedCity News

Monday, December 28th, 2020

Apart from efforts to develop vaccines for Covid-19, 2020 has been a year of substantial advancements in artificial intelligence (AI) and machine learning technologies that are being applied in healthcare as never before, resulting in improvements and enhancements in diagnosis and treatment that were previously impossible.

These technologies are advancing at an increasing rate, and we can be sure that AI will be used even more to overcome healthcare challenges in 2021 and beyond. Here are some of the main areas AI will be used to enhance digital healthcare in the near future.

OncologyMany healthcare practices today, including cancer diagnosis, still rely heavily on manual activities and processes and even those that do utilize digital technologies use them on an independent basis, not under one integral environment. Pathology, the medical specialty of diagnosing disease in patients, most notably cancer, is a good example. Traditional pathology involves manual processes that have remained unchanged for years, where glass slides with tissue samples are analyzed by pathologists using microscopes.

But that is changing today with a growing trend of moving toward digitized infrastructures and workflows (for example digital pathology). This trend is expected to accelerate as a result of the Covid-19 pandemic, increasingly saving time and labor costs while providing better and more cost-effective care. Moreover, adding an AI layer to an already digitized workflow can help make processes even more efficient on several fronts, including:

Triage: AI tools can help determine which cases should be reviewed more urgently and which physicians or resources to assign to them. This will ensure that each case is diagnosed by the physician whose capabilities can best be applied to the situation at hand, assigning cases based on a physicians sub-specialty or level of experience, which becomes especially important in complex cases.

Diagnosis: AI tools can also help with cancer diagnosis and assessment, pointing instantly to particular areas of interest, for instance those that include cancerous cells, and signaling the needle in the haystack factor that can shed light on a patients situation and what may be required to treat them. As a result, turnaround times for case reporting to the referring physician can be reduced significantly. In addition, smart AI tools will allow for the automation of some diagnostic tasks that are currently performed manually, such as counting cells, measuring features and automatically filling up parts of the report.

Next-generation diagnostics: With advanced machine learning capabilities and as more digital datasets become available, AI tools will be able to analyze more data and thus provide more insight than is currently possible. These tools will go beyond mimicking a physicians diagnosis; AI models will integrate extensive amounts of data from diverse sources (e.g., imaging, pathology and clinical data), acting as a sort of tumor board, where experts from multiple fields share their findings and knowledge to decide on the most accurate diagnosis and treatment. In the near future, we can expect to see AI serve as the perfect companion to the physician, with an unparalleled ability to combine huge amounts of fragmented information accurately and effectively.

Telehealth and Physician AccessThe need for quality healthcare keeps growing with an aging population and an increase in disease incidence. The number of physicians, however, does not grow at the same rate, and this creates a supply gap particularly evident for certain medical sub-specialties, in far-flung rural communities and sometimes even in urban centers. AI-based telehealth for instance, a new generation of affordable and accurate sensing devices that can be used to examine, monitor or diagnose patients remotely, as well as new communication technologies such as AI-based chatbots will help transform a visit to the doctors office into a completely different experience, enabling a more effective, frequent and affordable physician access for patients. The pandemic, with its frequent quarantines and regional lockdowns, only demonstrated the importance of these technologies as well as the shift needed in the mindset of all stakeholders: patients, physicians, providers and payers.

Personalized MedicineWith all the advancements in medical science, prognostic assessments and treatment decisions are many times not much better than a shot in the dark. For example, up to 75% of oncology patients (in a number of cancer types) do not respond to at least one of the available treatment drugs. Developing new biomarkers and genomic tests to more accurately predict prognosis and enable physicians to choose the right treatment is a costly, unpredictable, and painfully slow process.

Enter AI. Biomarkers based on artificial intelligence and machine learning can be an important, cost-effective and efficient way to develop tools for precision medicine. AI algorithms could provide new prognostic insights and help oncologists stratify patients into smaller, more homogeneous groups and assist in selecting personalized treatment for each patient based on a multitude of data types. These algorithms will combine pathology, radiology, genomic, clinical and demographic data, and analyze huge databases of medical records, treatments and outcomes. AI-driven solutions could also provide a more accurate and objective analysis of medical data, leading to new computational tests that replace or augment todays molecular tests.

Quality ControlObviously an essential part of any quality-driven system, quality control is a real challenge in labor-intensive processes. For example, for pathologists diagnosing cancer, an effective near bulletproof quality control requires having a second pathologist review the same biopsy again a time consuming and costly task. As a result, we find many clinical processes where quality control is done only on a small fraction of cases, if at all, often failing to detect errors.

AI and advanced algorithms can help create concurrent processes that rapidly review medical procedures and diagnoses, detecting mistakes early enough to avoid any damage. Fast and automated AI tools will enable pathology labs for the first time to apply rigid quality control standards to all their cases. Currently, the majority of cases are viewed by a single pathologist in almost all labs, which means that errors and misdiagnosed cancers may not be detected on time. AI can help transform this completely.

Algorithms can also alert on inconsistent findings, making sure the different medical disciplines provide a coherent picture of the patients condition and treatment plan, and that there are no holes in the process. An electronic medical record (EMR) that contains all the medical information of a patient could be constantly monitored by AI whenever something suspicious is detected, such as a lab test result that is inconsistent with a previous diagnosis, or a drug prescription that does not match the patients condition, the AI would highlight the inconsistency, prompting a thorough review by the relevant physician.

Screening ProtocolsDecisions on issues like which patient should be sent for a specific test CT, MRI, colonoscopy and others are currently conducted based on demographics or other general variables that often have nothing to do with a patients medical record. Going forward, we will see more medical screening thats based on specific characteristics identified by AI algorithms trained on large providers datasets. Such predictive algorithms will identify specific patterns, risk factors or correlations between multiple variables using advanced machine learning techniques.

Science-based medicine is one of the miracles of the modern age; lives are being saved today that just a few years ago would have been unsalvageable, and new, advanced treatments are providing a much better quality of life for many more than would have been possible in the past. Still, there are many domains in medicine and healthcare that could benefit from adopting the latest developments in artificial intelligence and machine learning and we see their role in improving healthcare becoming ever more important in the future.

More:
Predictions for AI-powered digital healthcare in 2021 - MedCity News

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The Increasing Use Of AI In The Pharmaceutical Industry – Forbes

Monday, December 28th, 2020

The pharmaceutical industry has long relied on cutting edge technologies to help deliver safe, reliable drugs to market. With the recent pandemic, its proved more important than ever for pharmaceutical companies to get drugs and vaccines to market faster than ever before.

Subroto Mukherjee, Head of Innovation and Emerging Technology, Americas at GlaxoSmithkline Consumer ... [+] Healthcare

Artificial intelligence and machine learning have been playing a critical role in the pharmaceutical industry and consumer healthcare business. From augmented intelligence applications such as disease identification and diagnosis, helping identify patients for clinical trials, drug manufacturing, and predictive forecasting, these technologies have proven critical. On a recent episode of the AI Today podcast Subroto Mukherjee, who is Head of Innovation and Emerging Technology, Americas at GlaxoSmithkline Consumer Healthcare discussed how AI and ML are being applied to the pharmaceutical industry and some unique use cases for AI and ML technology. In this follow up interview he shares his insights in more detail.

How is AI currently being applied in the pharmaceutical industry?

Subroto Mukherjee: AL and ML have been critical in the pharmaceutical industry and consumer healthcare business. AI and ML are playing an important role during this pandemic, driven by COVID and the race to discover effective vaccines. The top-level uses in Pharma and Consumer Healthcare arena as follows:

Apart from the Healthcare conditions, we see many AI ML usage in Digital Transformation areas for Pharma and Healthcare companies such as Martech, AdTech, Supply Chain, Sales, and Customer Service.

What are some unique use cases for AI and ML technology in the pharmaceutical industry?

Subroto Mukherjee: As per the article in guardian-Artificial intelligence group,DeepMindhas cracked a serious scientific problem that has stumped researchers for half a century. AlphaFold, the company and research laboratory using the AI program, showed it could predict how proteins fold into 3D shapes. The advantage of this discovery is that it will help researchers discover the mechanisms that drive some diseases and pave the way for - designer medicines, more nutritious crops, and "green enzymes" that can break down plastic pollution.

Another unique case and my favorite and involved in enabling the GSK consumer R&D team is AI in Sensory Science. AI and ML are ramping up predicting parameters in foods, beverages, agriculture, andmedicine. This could lead to hyper-personalized products for food, beverage, and medicines customized for different demographics and ethnicities; we extensively usesensoryproperties beyond taste, such as smell, appearance, and texture, influencing what we select to eat or drink.

Can you share use cases where AI was successfully applied at GlaxoSmithKline?

Subroto Mukherjee: Let me share some use cases in our consumer healthcare line of business.

Predictive Forecasting:We have popular seasonal brands in the Allergy and Cold and Flu category. The business use case is to have a predictive model that predicts how the upcoming season for allergy or cold and flu would shape up in different regions, and when are the predicted peaks and troughs. The advantage of this information is to inform consumers on our brand.com website, improve our national and regional media delivery and inform retailers of seasonal activation timing (distribution, stock up, display and secondary support).

Sensory Models Humans react differently, to taste, size, texture, color, and Sensory AI models help in a holistic way of understanding, predicting, and optimizing consumer preference. We use multiple parameters, such as taste, texture, color, and ML models, to understand the relationship between the consumer and the desired product experience. Our brands offer gummies, tablets, and liquids for our over-the-counter products, and these models are beneficial.

AI in eye-tracking:We do studies with our consumers and retailers in our shoppers science lab and monitor how they look at our products while they shop online or in stores. Consumers and retail teams with consent in our labs wear eye-tracking glasses and look at the products on shelf or online. During this process, images are captured and analyzed using AI. The analysis includes Areas of Interest (AOI) metrics, including the time to first fixation and time spent, gaze plots, heatmaps, and video replays. This helps in better product placement, improves our art and labeling, and helps us understand consumer behavior.

What are some of the challenges to AI adoption at larger organizations?

Subroto Mukherjee: Key challenges to AI adoption at larger organizations are as follows:

What are some of the challenges around data privacy, security, ethics, and transparency that organizations such as GSK are dealing with?

Subroto Mukherjee: Data privacy and security are of the highest importance for our organization. We constantly ensure all data privacy, security laws are followed, and appropriate training is provided across our different portfolios and adhered to by our partners and complementary workers. Data classification (PII, CSI, Sensitive), adherence of our systems, and processes to the GDPR or California privacy rights act's needs are some of the challenges we constantly face.

For AI ethics and transparency, we make sure MLOps processes are in place, and Machine learning (ML) models model scoring is established, monitoring and drift detection, the feedback loop is transparently followed. We bring a diverse ML team with diverse experience embedded in the team and test the models constantly to bring transparency and remove bias from the Machine learning models.

The global pandemic has really shaken up the pharma industry. How are you seeing AI and machine learning being put to use in the fight against the pandemic?

Subroto Mukherjee: Concerning the pandemic the biggest use of AI and machine learning from my understanding is to tease out COVID's biological secrets and identify the few molecules which will help end COVID among the millions and to reduce the time to market drugs either be discovery, development to clinical trials and final FDA approvals. Look at the speed and agility of the current vaccine it took 300 days from identifying the coronavirus genome to the first vaccine study, which has previously taken an average of eight to ten years.

Medical Mining - Let me focus on one specific initiative - "US White House - Call to Action." to analyze and Transform COVID-19 Data into Clinical Knowledge. White House is partnering with the AI research community to understand the novel coronavirus by mining medical literature. Natural language processing is one of the fastest-growing practices in this area, helping with this initiative. Medical imaging companies using AI and ML claimed record-level accuracy in detecting covid-induced pneumonia from CT scans, despite concerns from some stakeholders on the quality of training data.

Another important impact of COVID-19 is the impact of the supply chain. All companies, including ours, are facing the impact of COVID in the supply chain and manufacturing. Be it the supply of raw material or distribution of finished goods, it helps in pre-empting the risks associated with it. Companies are scrambling to respond to rapidly shifting consumer demand, limited supply of some products, and new workplace rules. AI and ML are used in Planning and Forecasting, Bots for automation and collaboration, and many key areas of the value chain.

How do large organizations approach change management for transformative technologies such as AI?

Subroto Mukherjee: We are implementing agile transformation across the business to create an effective and simple change management structure. Our technology organization, business team, and leadership team have undergone agile training. The change management discipline has been re-oriented with a clear hierarchy of approvals (key decision-makers) for onboarding new AI technology solutions. We define clear business objectives and value for now, next, and later for these transformative technologies.

What do you see as critical needs for workforce development around AI?

Subroto Mukherjee: We need reskilling and education among the workforce, not only in technical aspects but also in AI's business value. AI for Good or AI ethics is another key aspect that employees and the business community need to understand. Workers should not be afraid of AI, but rather embrace it and understand the benefits of AI. In terms of workforce, organizations need to scale up slowly with monitored results and a pool of data scientists knowing the business, data engineers, and subject matter experts.

How is the global regulatory environment impacting the pharma industrys adoption of AI?

Subroto Mukherjee: It is necessary to meet compliance and regulatory requirements as regulators need to safeguard consumers, and it does impact the timelines of new AI solutions to be rolled out. But organizations should be collaborating with regulators to streamline this process to the benefit of all. Both regulators and pharma companies can embrace AI and other digital transformation initiatives to drive the economy, cost efficiency, and value-driven effectiveness of regulatory operations.

What AI technologies are you most looking forward to in the coming years?

Subroto Mukherjee: I am looking forward to the advancement and extended use of Natural language processing, Robotics, Speech, and computer vision in the coming years.

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The Increasing Use Of AI In The Pharmaceutical Industry - Forbes

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The global metabolomics market size is projected to reach USD 4.1 billion by 2025 from USD 1.9 billion in 2020, at a CAGR of 13.4% – GlobeNewswire

Monday, December 28th, 2020

New York, Dec. 24, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Metabolomics Market by Product, Application, Indication, End User - Global Forecast to 2025" - https://www.reportlinker.com/p04763096/?utm_source=GNW However, issues related to data examination & data processing in metabolomics and the high cost of tools and instruments are likely to restrain the market growth to a certain extent.

By Product & Service, the metabolomics instrument accounted for the largest share of the metabolomics market.

The metabolomics instrument segment is expected to account for the largest market share in 2020. Factors such as the technological advancements in analytical instruments in terms of miniaturization, automation, and computerization; increase in the number of research-related activities worldwide in the field of medicine, nutraceuticals, and metabolomics; and strengthening healthcare infrastructure in developing nations for efficient disease diagnosis and treatment are expected to propel the growth of this segment during the forecast periodBy application, the biomarker discovery segment accounted for the largest share of the metabolomics market.The biomarker discovery segment is expected to account for the largest market share in 2020.The use of metabolic biomarkers to assess the pathophysiological health status of patients is increasing.

In recent years, as a result of significant technological advancements, metabolomics has become a vital tool in discovering biomarkers. By Indication, Cancer segment expected to grow at the fastest growth rate during the forecast period.

Based on indication, the metabolomics market has been segmented into into cancer, cardiovascular disorders, neurological disorders, metabolic disorders, inborn errors of metabolism, and other indications (respiratory and infectious diseases.The cancer segment is expected to account for the largest market share in 2020, with the highest growth rate as well.

This can primarily be attributed to the increasing number of patients who have cancer and the subsequent increase in the demand for cancer therapies.

By End user, Academic and Research Institutes accounted for the largest share of the metabolomics marketThe academic and research institutes segment accounted for the largest share of the metabolomics market in 2020. The increasing number of research activities in the field of metabolomics and funding to the academic and research institutes to conduct metabolomics research are the factors responsible for the largest share of the segment.

Asia Pacific: The fastest-growing region in the metabolomics market.

The Asia Pacific market is projected to grow at the highest CAGR during the forecast period.Several global pharmaceutical firms have entered the APAC market to tap the significant growth opportunities in emerging Asian countries and lower their production costs by shifting their drug discovery R&D operations and manufacturing to the region.

A large number of qualified researchers and low-cost operations in APAC countries, such as India and China, are some of the major factors supporting this trend.

North America: The largest share of the metabolomics market.

North America, which includes the US and Canada, accounted for the largest share of the metabolomics market. The large share of the North America region can be attributed to the presence of major players operating in the metabolomics market in the US, growing biomedical research in the US, and rising preclinical activities by CROs and pharmaceutical companies in the region.

Breakdown of primariesThe study contains insights from various industry experts, ranging from component suppliers to Tier 1 companies and OEMs. The break-up of the primaries is as follows: By Respondent Supply Side- 80%, Demand Side-20% By Designation Executives- 25%, CXOs- 20%, Managers - 55% By Region North America - 50%, Europe - 20%, APAC 20%, RoW- 10%

The metabolomics market is dominated by a few globally established players such as Waters Corporation (US), Agilent Technologies (US), Shimadzu Corporation (Japan), Thermo Fisher Scientific (US), Danaher Corporation (US), Bruker Corporation (US), PerkinElmer (US), Merck KGaA (Germany), GE Healthcare (US), Hitachi High-Technologies Corporation (Japan), Human Metabolome Technologies, Inc. (Japan), LECO Corporation (US), Metabolon, Inc. (US), Bio-Rad Laboratories (US), Scion Instruments (US), DANI Instruments S.p.A. (Italy), GL Sciences (Japan), SRI Instruments (US), Kore Technology Ltd. (UK), and JASCO, Inc. (US)

Research Coverage:The report segments the metabolomics market based on region (North America, Asia Pacific, Europe, Latin America and Middle East & Africa), product & service (metabolomics instruments ((separation tools (((gas chromatography, high-performance liquid chromatography, ultra-performance liquid chromatography, and capillary electrophoresis))), detection tools (((nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and surface-based mass analysis))), bioinformatics tools and services) application (biomarker discovery, drug discovery, toxicology testing, nutrigenomics, functional genomics, personalized medicine, and other applications), indication (cancer, cardiovascular disorders, neurological disorders, metabolic disorders, inborn errors of metabolism, and other indications),end user(academic and research institutes, pharmaceutical & biotechnology companies, contract research organizations, and other end users).Company type (Tier 1, tier 2, Tier 3 providers of metabolomics instruments and services).

The report also provides a comprehensive review of market drivers, challenges, and opportunities in the metabolomics market.

Key Benefits of Buying the Report:The report will help the leaders/new entrants in this market with information on the closest approximations of the revenue numbers for the overall market and the sub-segments.This report will help stakeholders understand the competitive landscape and gain more insights to better position their businesses and plan suitable go-to-market strategies.

The report also helps stakeholders understand the pulse of the metabolomics market and provides them information on key market drivers, challenges, and opportunities.

Read the full report: https://www.reportlinker.com/p04763096/?utm_source=GNW

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The global metabolomics market size is projected to reach USD 4.1 billion by 2025 from USD 1.9 billion in 2020, at a CAGR of 13.4% - GlobeNewswire

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Robert Gallo of the UM School of Medicine Institute of Human Virology and Global Virus Network Awarded Top Life Sciences and Medicine Prize from China…

Monday, December 28th, 2020

BALTIMORE, Dec. 21, 2020 /PRNewswire/ --Robert C. Gallo, MD, The Homer & Martha Gudelsky Distinguished Professor in Medicine, co-founder and director of the Institute of Human Virology at the University of Maryland School of Medicine and co-founder and international scientific advisor of the Global Virus Network, was awarded the "VCANBIO Award for Biosciences and Medicine," a significant and authoritative award in the life sciences and medicine field of China. The elite Prize is jointly presented by the University of Chinese Academy of Sciences and the VCANBIO CELL & GENE ENGINEERING CORP, LTD to push forward scientific research, technological innovation and continuous development in the life sciences and medicine field of China.

"The Prize also serves to facilitate the industrial development and application of innovative life science achievements,"said George F. Gao, DVM, DPHIL (OXON), Director General of the Chinese Center for Disease Control and Prevention (China CDC), Director, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Professor, Institute of Microbiology, Dean of the Medical School of the Chinese Academy of Sciences and Director of China's Global Virus Network Center of Excellence. "Dr. Gallo is a pioneer in virus research and most worthy of this Prize. We are pleased to see him recognized by many members of the Chinese Academy of Sciences."

"Hosted by the Medical School of the University of Chinese Academy of Sciences, this award commends outstanding and innovative Chinese and foreign scientists, who have accomplished innovation achievements and breakthroughs in the life sciences and medicine field,"said Yiming Shao, MD, the Chief Expert on AIDS, China CDC, Director of the Division of Research on Virology and Immunology, National Center for AIDS/STD Control and Prevention, China and Member of the GVN SARS-CoV-2 Task Force and China GVN. "I have worked with Dr. Gallo through the decades and admire his intellect and leadership, which have led to discoveries that have broad implications in protecting mankind from viral threats. I am delighted that my Chinese colleagues are recognizing him with this significant honor."

"Prof. Gallo has made a great deal of contribution to promote the Sino-American friendship and collaboration, especially for medical talent training and public health in China,"said Prof. Guanhua Xu, Chairman of the selection committee of the VCANBIO Award for Biosciences and Medicine.

"This is a tremendous and well-deserved honor for Dr. Gallo,"said E. Albert Reece, MD, PhD, MBA, Executive Vice President for Medical Affairs, UM Baltimore, the John Z. and Akiko K. Bowers Distinguished Professor, and Dean, University of Maryland School of Medicine. "Dr. Gallo has dedicated his career to building international collaborations that have produced major scientific discoveries in human virology, including with leading scientists and academic colleagues in China. As a result, the Institute of Human Virology continues to be recognized as the global leader in the fight against chronic viral diseases."

"I am humbled and honored to receive this esteemed Prize from my colleagues in China,"said Dr. Robert Gallo. "I take this opportunity to stress that it is imperative that government and politics not interfere with science, and that my Chinese and American colleagues, who have a long history of collaborating together and contributing scientific breakthroughs to protect humanity from global health threats, continue to have the freedom to do so and to grow these collaborations."

A Distinguished Scientific Career Advancing Global Health

Dr. Robert Gallo has long believed in the necessity of international cooperation and collaboration in medical sciences in general, and infectious diseases in particular, in part to build global friendships and advance humanitarian principles. Though entertainment and sports facilitate such connections he believes the "knots" are tied best through medical sciences. Throughout his 30 years at the National Institutes of Health (NIH) and more recently his nearly 25 years at Baltimore's Institute of Human Virology (IHV) at the University of Maryland School of Medicine, he has fostered these connections. First, through his pioneering scientific discoveries including his discovery in 1976 of Interleukin-2, the first cytokine, a growth regulating substance now used as immune therapy in some cancers and in autoimmune diseases when suppressive T cells are needed. Then in 1980, the first human retrovirus, HTLV-1, a cause of human leukemia and paralytic neurological diseases as well as severe inflammatory disorders, which is endemic in some regions such as parts of Africa, the Caribbean Islands, Japan, Aboriginal Australians, Iran and South America. Dr. Gallo and his team developed a blood test for HTLV-1 applicable to all countries which protects people receiving blood transfusions that would be contaminated with this virus. Similarly, in 1984, when he and his team co-discovered HIV as the cause of AIDS they also developed the HIV blood test for the world and made their reagents available to all. Dr. Gallo and his team established collaborations in HIV/AIDS research, education, therapy and care for many African countries, particularly in Nigeria and some Caribbean nations. During the current pandemic he quickly became involved in initiating preventive measures against SARS-CoV-2 and COVID-19 disease through the idea of stimulating innate immunity with "live" virus vaccines such as the oral polio vaccine. Dr. Gallo, abetted by his collaborator, Konstantin Chumakov, PhD, Associate Director for Research for the U.S. Food and Drug Administration's (FDA) Office of Vaccines Research and Review and a GVN Center Director and his clinical colleague, Shyam Kottilil, MBBS, PhD, professor of medicine and director of the Clinical Care and Research Division of the Institute of Human Virology at the University of Maryland School of Medicine and senior advisor at the GVN, are advising on trials in India and in discussion about trials in Mexico, Brazil, Uzbekistan and China. He has also fostered the international nature of his research by hosting students beyond the U.S., including post-doctoral senior scientists from Asia, Middle East, Europe, the Americas and many African nations.

However, nothing demonstrates his concern for medical science cooperation more than when he established the idea for the Global Virus Network (GVN), which he co-founded in 2011 with the late Prof. Reinhard Kurth, MD, formerly Director of the Robert Koch Institute in Berlin, and Prof. William Hall, BSc, PhD, MD, DTMH, of University College Dublin. Now, GVN is headed by its President Christian Brchot, MD, PhD. The GVN was formed to advance medical and zoological science without any government influence, giving members of the GVN maximum freedom to speak freely while encouraging all nations to be involved. China, among several dozen other countries, has an active Center of Excellence within the GVN and was the site of the 7th meeting of the GVN in May 2015 held in Beijing and hosted by the late GVN Center Director, Zeng Yi of Beijing University of Technology. Experts shared information on varying viral threats, including those causing hemorrhagic fevers, hepatitis, HIV, measles, influenza, dengue and chikungunya, to name a few. GVN members also reviewed strategies at the center of the organization including the creation of specialized task forces and the launch of training programs to address growing viral threats.

A History with Chinese-American Collaborations

Dr. Gallo had a deep friendship with Dr. Robert Ting who came to the U.S. as a child refugee from Shanghai during the Japanese invasion. As a student, Dr. Ting worked with the famous Italian molecular biologist, Dr. Salvatore Luria at MIT, who won a Nobel Prize. Dr. Ting then went to Caltech to work with another Italian Nobel Prize winner, Dr. Renato Dulbecco and they were joined by two others who were soon to be Nobel Prize winners, Drs. Howard Temin and David Baltimore. Dr. Ting was not just Dr. Gallo's friend but also his teacher by introducing him to Chinese culture and food, tennis, and the field of virology. Soon after meeting Dr. Ting, another Chinese-born and educated young man, Dr. Alan Wu, came to Dr. Gallo's lab from Toronto bringing with him the knowledge and skills of blood stem cells. There were then several other Chinese post-doctoral fellows culminating with Dr. Flossie Wong-Staal from Canton Province and who played a very major role in advancing molecular biology on Dr. Gallo's team for about 15 years. Dr. Nancy Chang, also Chinese, came as a visiting scientist on a few occasions. On one such time she was key to the development of the second-generation HIV blood test used around the world.

In 2009, with the help of a University of Maryland School of Medicine colleague, Dr. Richard Zhao, born in China and educated in the U.S., the Shandong Academy of Medical Sciences (SAMS) announced the establishment of the Shandong Gallo Institute of Virology (SGIV). The announcement was made simultaneously with a ceremony to establish China's first Molecular Diagnostic Center for Personalized Healthcare (MDCPH), which was a joint venture among the University of Maryland, Baltimore, Roche Diagnostics Asia Pacific and SGIV at the Shandong Academy of Medical Sciences. The mission of the SGIV is to promote the basic science of virology especially in the area of HIV/AIDS and other important and emerging viral diseases and to facilitate translational research and clinical trials for related diseases. SGIV also aims to provide molecular-based testing for disease diagnosis, prognosis and treatment in the area of individualized molecular testing for personalized medicine.

Since the founding of the Institute of Human Virology (IHV), Dr. Gallo notes that several of his key science leaders at the Institute of Human Virology came from China, including: Dr. Wuyuan Lu (recent Director of the Division of Infectious Agents and Cancer), Dr. Yang Liu (recent Director of the Division of Immunotherapy), Dr. Pan Zheng (Division of Immunotherapy), Dr. Lishan Su (current Director of the Division of Virology, Pathogenesis and Cancer), Dr. Man Charurat (current Director of the Division of Epidemiology and Prevention and Ciheb) and Dr. Lai-Xi Wang (formerly at IHV and now at University of Maryland, College Park). With each of these leaders also came labs full of Chinese colleagues, who Dr. Gallo states contributed greatly to advancing America's biomedical research. Further, over the past six decades, Dr. Gallo visited China countless times to discuss potential collaborations with public and private sector entities, mentored rising Chinese scientists and facilitated open scientific discussions to advance the field of human virology, among other important things.

About the Institute of Human Virology

Formed in 1996 as a partnership between the State of Maryland, the City of Baltimore, the University System of Maryland, and the University of Maryland Medical System, the IHV is an institute of the University of Maryland School of Medicine and is home to some of the most globally-recognized and world-renowned experts in all of virology. The IHV combines the disciplines of basic research, epidemiology, and clinical research in a concerted effort to speed the discovery of diagnostics and therapeutics for a wide variety of chronic and deadly viral and immune disorders - most notably, HIV the virus that causes AIDS. For more information, visit http://www.ihv.org and follow us on Twitter @IHVmaryland.

About the Global Virus Network (GVN)

The Global Virus Network (GVN) is essential and critical in the preparedness, defense and first research response to emerging, exiting and unidentified viruses that pose a clear and present threat to public health, working in close coordination with established national and international institutions. It is a coalition comprised of eminent human and animal virologists from 59 Centers of Excellence and 11 Affiliates in 33 countries worldwide, working collaboratively to train the next generation, advance knowledge about how to identify and diagnose pandemic viruses, mitigate and control how such viruses spread and make us sick, as well as develop drugs, vaccines and treatments to combat them. No single institution in the world has expertise in all viral areas other than the GVN, which brings together the finest medical virologists to leverage their individual expertise and coalesce global teams of specialists on the scientific challenges, issues and problems posed by pandemic viruses. The GVN is a non-profit 501(c)(3) organization. For more information, please visit http://www.gvn.org. Follow us on Twitter @GlobalVirusNews

SOURCE Global Virus Network

gvn.org

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Robert Gallo of the UM School of Medicine Institute of Human Virology and Global Virus Network Awarded Top Life Sciences and Medicine Prize from China...

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Coagulo Medical Technologies Announces $6.5 Million in Financing to Accelerate Delivery of Disruptive Coagulation Diagnostics Platform – Business Wire

Monday, December 28th, 2020

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Coagulo Medical Technologies, an MIT-born startup that has developed the worlds first precision-medicine platform for comprehensive and targeted blood clotting management, today announced it has raised $6.5 million in financing from 20/20 HealthCare Partners, Sands Capital, Good Growth Capital, IAG Capital Partners and private investors. The Boston area diagnostics innovator also announced that it has been awarded a Small Business Innovation Research (SBIR) grant by the National Science Foundation to accelerate delivery of breakthrough innovations amid the global COVID19 public health crisis, which has called attention to the limitations of conventional coagulation tests.

Coagulos rapid, point-of-care device is a major advancement for personalized diagnosis and management of all coagulation-related diseases. The device is ultra-portable, requires just drops of blood and will provide vital, clinically-actionable information within 10 minutes. It leverages a proprietary and entirely novel approach to coagulation testing, which is capable of parsing through the entire coagulation cascade to pinpoint deficiency or inhibition of specific coagulation factors and quantifies their effect on clotting time.

Current coagulation testing methods were developed over a half-century ago, provide only general information on blood clotting function and cannot identify the specific cause of a clotting abnormality. Outdated testing technology is akin to a generic check engine light, whereas Coagulos test is designed to isolate the issue down to a specific diagnostic code. The device promises better health outcomes by permitting physicians to supplement clinical intuition with targeted information that they always wanted but no other technology could deliver, said Dr. Galit Frydman, CSO and President of the company. To be able to seamlessly deliver those comprehensive, sample-to-insight results using merely drops of blood, and to have that information within a clinically meaningful timeframe and at the bedside, will make Coagulos diagnostic platform a critical tool in meeting the ever-evolving challenges of coagulation management, added Jarrod Niebloom, Coagulos CEO and Chairman of the Board of Directors. No doubt the complex clotting issues that continue to be observed in patients with COVID19 epitomize just how antiquated existing diagnostic tools are and how pressing the clinical need is.

Coagulo has developed a platform that directly responds to current medical needs and, further, will support traditional tests like prothrombin time and activated partial thromboplastin time, said Hillel Bachrach, managing partner of 20/20 HealthCare Partners. We are excited to invest in Coagulo and to help accelerate their path to market as they up-end an industry that has seen very little innovation for decades.

20/20 HealthCare Partners, a global investment group based in Boston that invests at the early stage of technology and life science innovation, has led the investment.

About Coagulo:

Founded in 2018 and based out of Alexandria LaunchLabs, Coagulo licensed technology out of MIT and the Massachusetts General Hospital (MGH) developed by Dr. Galit Frydman, the companys CSO and President, who also holds appointments in the Division of Trauma, Emergency Surgery and Surgical Critical Care at MGH and in the Center for Biomedical Engineering at MIT. Coagulo has developed the next-generation of rapid, ultra-portable and comprehensive diagnostics for the personalized diagnosis and management of all coagulation-related diseases. Coagulos point-of-care device is not yet approved or cleared by the U.S. Food and Drug Administration for marketing in the United States.

http://www.coagulomed.com

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Coagulo Medical Technologies Announces $6.5 Million in Financing to Accelerate Delivery of Disruptive Coagulation Diagnostics Platform - Business Wire

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The Precision Medicine Market To Transcend The Covid-19 Barrier From 2024 Onwards – Farming Sector

Monday, December 28th, 2020

Market Report Summary

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The latest report published by Persistence Market Research titled Global Market Study on Precision Medicine: Drug Discovery Technology Segment Estimated to Witness 0.1% Decline in Market Share Between 2016 and 2024. projects some of the crucial aspects of the globalprecision medicine marketafter an in-depth research. The report assures that the market will grow manifold and it will register a 14.7% CAGR between 2016 and 2024.

Global Precision Medicine Market: The Propellers

The global expansion of the medicine industry will expand the canvas of the global precision market. Larger investments, better infrastructure, simplified approval process of drugs along with companion diagnostics will impact the structure of the entire climate of the global precision medicine market.

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The affordable DNA profiling, the bloating cancer population of the globe will create a favorable condition of growth for the global precision medicine market. The proper storage of genome data plays a crucial part in this segment. The emergence of data backed medicare will also drive the global precision market ahead.

But the market is combating acute data storage and data privacy issues and it also lacks in systematic approach towards funding and soaring prices of personalized drugs is also creating a blockade in the expansion of the global precision medicine market.

Global Precision Medicine Market: Market Autopsy

The global precision medicine market is bifurcated into multiple parent segments which are further sub-categorized. The primary division of the market is an assimilation of three, region, technology and application. The major technologies which will define the market character in the forthcoming years are bioinformatics, next-gen sequencing and drug discovery technology. The applications segment will showcase fruitful results and oncology will act as the showstopper.

The market prediction shows that this segment will bloom and will touch an approximate value of US$ 69 Bn by the end of the assessment period. The approximate registered CAGR of this segment within the assessed period will be above 13.5%. The global population is struggling with some of the acute diseases such as arthritis. A large slice of the aged population is an easy prey of this crippling ailment. The immunology segment will reap maximum benefits from the population affected by arthritis. The immunology segment will gain revenue from the market and the market worth will cross US$ 34 Mn by the end of 2024.

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Global Precision Medicine Market: Regional Scrutiny

The regional market arena has penetrated through different key regions of the globe. The global precision medicine market has extended its boundaries in the last few years. The product has a massive global presence and it is expanding steadily. Apart from North America, Europe, MEA, Latin America and Asia Pacific regions are other major pockets which are expected to show fruitful outcome in the forthcoming years.

The global precision medicine market is expected to perform well in the North American region and it will occupy more than 35% of the market share within the period of prediction. The global precision market in North America will flourish and will probably touch the approximate market value of more than US$ 60 Mn by 2024 end. With a stupendous performance the US and Canada will conquer a lion share of the global precision medicine market of this region predicts the report.

The Europe is a consistent market and will crawl up the revenue chart within the forecast period. The global precision market in Europe will ride an estimated CAGR of more than 13% to sew up an average worth of more than US$ 40 Mn by the end of 2024. In Europe the markets spread across Germany and France will shape the destiny of this market. Apart from this the countries such as Spain, UK and Italy will also follow the leading pack during the period of assessment.

The APAC region is the rising star of the global precision medicine market. The region will project a CAGR of more than 14% during the period of projection. The market will witness a staggering hike and will touch approximately US$ 35 Mn by the end of 2024. In the APAC region Japan will spearhead the market, China and India will lock horns to accumulate maximum market share during the projected period.

The region of Latin America will score considerable revenue during this period. MEA will be a sulking market as less of research activities will dampen the spirit of the precision medicine market.

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To support companies in overcoming complex business challenges, we follow a multi-disciplinary approach. At PMR, we unite various data streams from multi-dimensional sources. By deploying real-time data collection, big data, and customer experience analytics, we deliver business intelligence for organizations of all sizes.

Our client success stories feature a range of clients from Fortune 500 companies to fast-growing startups. PMRs collaborative environment is committed to building industry-specific solutions by transforming data from multiple streams into a strategic asset.

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The Top Five Hypergrowth Industries I’m Targeting In 2021 – Forbes

Monday, December 28th, 2020

dpa/picture alliance via Getty Images

Here are the top new hypergrowth industries Im focused on right now. My research shows all of them will soon have their breaking out moment in 2021:

1.Synthetic Biology

Synthetic biology is a brand-new sector where breakthrough technology allows scientists to program living things. Im sure youve seen the DNA double helix before.

Source: edn.com

DNA is basically your bodys unique set of instructions. Its what makes you, you. Your unique DNA makeup determines what you look like, how your body functions. Think of DNA as the source code of every living thing on Earth. Synthetic biology gives us the tools to edit and create the DNA of an organism to get it to do something entirely new. Basically, it allows scientists to alter the makeup of living things.

How does it work? In short, engineers design sequences of DNA on computers. Then they physically print out those sequences and insert them into living things. This can then add beneficial character traits to a living thing.

For example, scientists already use it to make self-fertilizing plants. Joyn Bio used fake DNA to modify the microbes of plants so they can pull nitrogen gas from the air and convert it into fertilizer. Using synthetic biology, scientists have also created a reliable source of artemisinin which is used in malaria vaccines.

Fake meat pioneer Beyond Meat also harnessed this new technology to create more realistic veggie burgers. It was first to use a DNA coding sequence from soybeans to create meat that looks and tastes like beef but is actually made from vegetables.

In short, this breakthrough tech allows scientists to reprogram the operating system of plants and other organisms. Synthetic biology is hands down the most cutting-edge industry on earth right now. Just as Intels microchips and IBMs computers underpinned Americas computing revolution,Twist BiosciencesDNA synthesis platform provides the building blocks for the biology revolution.

2.Genomics

DNA carries your genetic information. Think of it as a set of instructions for your body. Mapping your DNA allows scientists to decipher your bodys unique set of instructions. By learning the secrets hidden within your DNA, doctors can tell what diseases youre likely to get. This allows them to catch problems earlier and diagnose them more accurately.

In fact, the use of DNA mapping in healthcare is exploding right now. A new prenatal test based on DNA mapping can detect hard-to-find problems with babies inside their mothers wombs. Its the fastest-growing medical test in American history.

Invitae(NVTA)is using these breakthroughs to turn Americas healthcare system on its head. In short, its building an alternate healthcare industry around DNAor geneticinformation.

By the end of 2020, Invitae will have mapped the DNA of almost one million Americans. And its creating a system where this information is used in our healthcare decisions. For example, most cancers have a genetic link. In other words, mapping DNA can help detect the disease early. And when it comes to cancer, an accurate and timely diagnosis can literally save your life.

But right now, many cancers go largely undetected. Invitae is working to change this. I see genetic mapping ushering in the era of personalized medicine in America. If you havent heard about this yet, you will soon.

In short, DNA mapping will allow you, as an individual, to know which diseases youre most at risk for. Knowing this, youll better understand the perfect foods, the perfect drugs, and the perfect exercise regimen, just for you.

But thats only stage one. The genomics industry is evolving from mapping our DNA to editing it. Gene editing promises to transform how we treat and cure disease. Humans have between 20,000 and 25,000 genes that carry the DNA instructions for our bodies. But devastating diseases like cystic fibrosis and sickle cell anemia are caused by just one error.

Gene editing is making cures for certain diseases possible for the first time in history. It has the potential to cure thousands of diseases like cystic fibrosis, Huntingtons, sickle cell anemia, and hemophilia.

Space has always been a business dominated by governments. The Space Race between America and the Soviet Union kicked off back in the 1950s. And since then, the US government has pumped $600+ billion into NASA. That dwarfs the $20 billion that private companies have invested in space.

But over the past decade, theres been a quiet revolution in the space industry. The advent of reusable rockets and innovative launch methods have slashed the cost of going to space. The cost to launch a satellite into orbit has dropped more in the past 10 years than in the entire history of space!

Rapidly declining costs are transforming space travel into a thriving business. In fact, private space investment has jumped 400% since 2013. Elon Musks intergalactic company SpaceX has launched 20+ resupply rockets to the International Space Station over the past few years. And earlier this year SpaceX sent its first two astronauts into space on its Crew Dragon capsule. It was the first privately built rocket and capsule ever to put humans into space.

Amazon founder Jeff Bezos is also pushing private space exploration forward. His company, Blue Origin, recently won a NASA contract to put Americans back on the moon. In short, the era of private space exploration is here. Over the coming years, tourists will fly into outer space, companies will figure out how to mine asteroids, and companies likeMaxar Technologies (MAXR)will continue to improve their fleets of spy satellites.

Over the past decade, investors have poured a record $26 billion into 535 space companies globally. Last year alone $5.8 billion was investeda new record. In fact, data from the Space Foundation shows the space economy generated $415 billion in revenue last year. Current industry projections peg the 2040 global space economy at between $1 and $3 trillion.

And keep in mind, government activity in space is growing once again. The Commerce Department revitalized the Office of Space Commerce, which was established over 30 years ago to help enable commercial space activities. Last December, Congress approved a $738 billion defense policy bill to create a Space Force, the sixth branch of the US military.

The core idea of artificial intelligence (AI) is a machine that learns and thinks just like you or me. Most important, it learns all by itself, without human intervention. But please understand, AI isnt one single all-knowing machine like you see in the movies. Instead, it describes intelligent computers that do ultra-specific tasks.

For example, right now machines are learning to see for the first time ever. This is the basis of the flourishing computer vision industry. Medical imaging disruptor Paige is using computer vision to revolutionize the way we diagnose cancer. Paige fed millions of real-life medical images into its computer program and taught it to detect early signs of tumors.

And it recently tested the system by scanning 12,000 medical images for potential tumors. It had never seen these images before, yet achieved near-perfect accuracy. In other words, this computer has learned to recognize cancerous tumors better than human doctors. Paige is just one example of machines performing like superhuman doctors.

Stanford researchers recently built a computer that scans MRIs to detect Alzheimers disease with 94% accuracy. Other teams are teaching computers to drive. Amazon recently acquired top self-driving car startup Zoox for $1.2 billion. Zooxs computer on wheels is so good at driving it can zip through San Franciscos busy streets without a human driver.

Then you have firms developing checkout-free grocery stores, which turns your local Whole Foods into a giant supercomputer. Earlier this year, Amazon launched its Dash Cart. The shopping cart uses computer vision algorithms and sensors to identify the items in the cart. So you can simply grab items, throw them in the cart, and walk out.

In short, these are all world-changing technologies that will make many folks rich. Many new, unique disruptions are hiding underneath the misleading banner of AI.

Do you remember when every company had a dedicated payroll department?Now most businesses outsource it to companies like Paylocity and Paycom. In fact, offloading your payroll department makes total sense. Why do it yourself when you can pay a specialist to do it for less?

And as businesses outsourced their payroll needs, Paylocity and Paycoms stocks surged. This outsourcing phenomenon isnt just confined to payroll anymore. All kinds of functions that used to be done in-house like accounting, web design, IT support, and data storage are being offloaded now. For example, most companies that need to build a website no longer hire a whole web design team. Instead, they pay firms like Shopify and Wix to handle all their online needs.

Firms still employ armies of accountants to look after their finances. But this is rapidly changing. An upstart called BlackLine has created software that automates most accounts payable and receivable jobs. It now counts major firms like Nike, Costco, and Dominos as customers. And its stock has shot up 300%+ in the past couple years.

Remember when every office in America had a dedicated server room? The in-house IT department would look after the companys systems. And ensure hackers couldnt steal valuable data.

IT departments are now shrinking rapidly. Instead of employing dozens of workers to stop hackers, companies now simply pay cybersecurity firms likeOktaandZscalera monthly fee to protect their networks.

Then you have a company likeSmartsheet, which is automating much of what project managers used to do. Its app basically allows teams to collaborate, manage, and report on work in real time. And its stock has surged 150%+ over the past couple months.

All these jobs used to be done by in-house employees. Now they are being outsourced to specialist firms. And the firms pioneering new software products have been among the best-performing stocks in the entire market.

Get my report"The Great Disruptors:3 Breakthrough Stocks Set to Double Your Money".These stocks will hand you 100% gains as they disrupt whole industries.Get your free copy here.

Originally posted here:
The Top Five Hypergrowth Industries I'm Targeting In 2021 - Forbes

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AI In Cancer Care: How It’s Making a Difference In Treatment And Care – Entrepreneur

Monday, December 28th, 2020

One of AI's key strengths is that it is able to process vast and complicated data in short amounts of time, and help automate routine tasks to reduce the level of human intervention needed

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December23, 20205 min read

Opinions expressed by Entrepreneur contributors are their own.

You're reading Entrepreneur India, an international franchise of Entrepreneur Media.

Cancer incidence continues to grow worldwide. As per the latest figures from WHOs cancer database GLOBOCAN, 19.3 million new cases of cancer were reported in 2020.This figure is expected to rise to 27.5 million new cancer cases diagnosed each year by 2040. Thus, cancer will remain a key global health issue and utilize a significant chunk of our healthcare resources.

Many countries such as India face challenges in terms of limited healthcare resources available to treat the swelling number of cancer cases. The ratio of patients seeking care for cancer to the availability of cancer specialists is very high compared with developed countries. Indian oncologists, on average, treat a much larger number of cancer patients than their Western counterparts. The pathologist-patient ratio is also highly skewed, and hence the cancer care infrastructure in India faces enormous time pressure, with doctors having to examine a staggering amount of information to make treatment decisions, for every single cancer patient. The result is overcrowded health care facilities and long waiting periods in hospitals equipped to deal with cancer.

This is where artificial intelligence (AI) can be a game changer. One of AIs key strengths is that it is able to process vast and complicated data in short amounts of time, and help automate routine tasks to reduce the level of human intervention needed.

Application to image analysis allowing better screening and more efficient diagnosis

Early detection of cancer is the key to saving the lives of patients. A group at MIT developed a new deep learning-based prediction model that can forecast the development of breast cancer up to five years in advance. Their model was trained on mammograms and patient follow-up data to identify patterns that would not be obvious to or even observable by human clinicians. The results have so far shown to be far more precise, especially at predictive, pre-diagnosis discovery.

Wholeslide imaging is becoming routine in developed countries, which has resulted in the accumulation of digital pathology images and allowed the application of deep learning to pathological diagnosis. A deep learning convolutional neural network, or CNN, developed by a team from Germany, France and the US can diagnose skin cancer more accurately than dermatologists. In a recently reported study, the software was able to accurately detect cancer in 95 per cent of images of cancerous moles and benign spots, whereas a team of 58 dermatologists was accurate 87 per cent of the time.

Personalized medicine

By applying AI and machine learning to multiple data sourcesomics data, electronic health records, sensor/wearables data, environmental and lifestyle dataresearchers are taking first steps toward developing personalized treatments for diseases from cancer to depression. Here, AI is in action today and making great strides in cancer treatment by leveraging patient medical history and tumour characteristics to help generate multiple treatment options.

Various AI/ML models for breast cancer prognosis have successfully transitioned to clinical use. These models help accurately determine the risk of a patient suffering from a relapse, based on which treatment can be personalized. If a breast cancer patient has a low risk of relapse, then they could potentially avoid chemotherapy and all its side-effects. Other localized cancer treatments such as radiation are also increasingly relying on AI. Radiation oncologists are already using AI-driven software to create plans for personalized radiation therapy.

In the near future, AI/ML can mine large datasets (scans, blood work-up, patient follow-up from thousands of patients at one time) to detect early signs of patients who are responding to treatment, and those who are not.

Drug development

AL/ML can be applied in multiple stages of new drug discovery including designing the chemical/protein structure of drugs, target validation, investigating drug safety and managing clinical trials. The hope is that use of AI/ML in drug discovery will not only help significantly reduce thecost ofintroducing new drugs tothemarket, but also make the drug discovery process faster (currently 10-15 years including clinical trials) and more cost-effective (currently costs almost $1 billion per new drug). Companies today use deep learning software to sift through millions of possible molecules in a day or two, which would normally take months via traditional methods.

In conclusion, some AI solutions have already been deployed in clinical practice, but the industry has a long way to go.

In my opinion, AI should be seen as something that can help cancer specialists spend less time on routine tasks, reduce variability and human error rather than replace the specialists altogether. AI can sift through large data sets and aid in decision making rather than be a standalone tool for diagnosing or treating patients in a completely unsupervised environment. Also, we must ensure that the data going in to make the AI based algorithms must be of the highest quality/standards to ensure we get the most accurate algorithms in return.

With all the fears about AI making many jobs redundant, oncology could be a great example of how humans and technology can work together rather than against each other.

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AI In Cancer Care: How It's Making a Difference In Treatment And Care - Entrepreneur

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