StemCell Therapy

Nitt Hanprathet,1 Somrat Lertmaharit,1 Vitool Lohsoonthorn,1,2 Thanapoom Rattananupong,1 Palanee Ammaranond,3 Wiroj Jiamjarasrangsi1,2

1Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand; 2Department of Preventive and Social Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand; 3Department of Transfusion Medicine, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand

Correspondence: Wiroj JiamjarasrangsiDepartment of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Rama IV Road, Pathumwan, Bangkok 10330, ThailandTel +66 2 256 4000 ext. 3700Fax +662 256 4292Email wjiamja@gmail.com

Purpose: The gender differential evidence of the association between shift work and type 2 diabetes risk remains scarce. This longitudinal study determines whether the association between shift-work exposure and type 2 diabetes risk and abnormal fasting plasma glucose (FPG) differs according to gender; the study aims to find the association between shift work and changes in physiological, behavioral, and psychosocial stress.Patients and methods: This retrospective cohort study was conducted among 5947 workers (4647 female and 1300 male) aged 60 years old in Bangkok, Thailand. Participants required a normal FPG level (<100 mg/dL) at baseline and at least two health check-up results from 2009 to 2016. Shift-work exposure history was assessed using a self-administered questionnaire; FPG levels were measured annually. Cox proportional hazard models were used to assess the aforementioned association.Results: During the follow-up period, 1470 new abnormal FPG and 154 new type 2 diabetes cases developed. Stratified analysis of male workers data revealed an association was significant in the unadjusted model, which tended to be stronger after adjustment for demographic data and the baseline values of anthropometric and biochemical parameters. This was the case both for type 2 diabetes [Hazard Ratio (HR) (95% Confidence Interval (CI))=2.98 (1.585.62)] and abnormal FPG [HR (95% CI)=1.86 (1.432.41)]; this association was less obvious among women.Conclusion: Shift work is a risk factor for type 2 diabetes and abnormal FPG; this risk is gender differential, being more pronounced in men. Preventive measures aiming at ameliorating shift work induced type 2 diabetes risk should pay more attention to men.

Keywords: shift-work exposure, diabetes, abnormal fasting plasma glucose, gender difference, behavioral stress, retrospective cohort study, Cox proportional hazard models

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

See the original post:
Increased Risk Of Type 2 Diabetes And Abnormal FPG Due To Shift Work D | DMSO - Dove Medical Press

This entry was posted on November 12, 2019 at 4:47 pm and is filed under Diabetes. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed. |