Basic ingredients and dietary supplements such as Saccharomyces cerevisiae yeast can have functional properties in the diet and yield satisfactory results when added to feed as active cells (autolysed or hydrolysed) inactive cells or as cell wall components.
It is known that the fermentation environment that will provide the fundamental differences in the final product composition is more important than yeast strain. The strains used in sugarcane processing to obtain ethanol will result in a product with a higher -glucans concentration. Yeast culture goes through numerous fermentation cycles, which makes cell wall denser, resulting in higher carbohydrate rates and lower fat content, making it less digestible in the gastrointestinal tract.
Photo: Henk Riswick
With the restrictions imposed by regulations in Brazil and abroad, as well as the demand of the consumer market for natural and healthy products in animal feed, several alternatives have been tested and used in the animal industry. However, many factors are considered by producers to obtain the highest cost-effectiveness, such as the action of these compounds on animal metabolis.
Natural additives found on the market are capable of providing compounds that stimulate the body to respond more efficiently to the stressful stimuli imposed in the field. Among the options available, ImmunoWall and Hilyses stand out for being natural Saccharomyces cerevisiae yeast-based products, with no use restrictions to any animal species.
ImmunoWall is composed of Saccharomyces cerevisiae cell wall and contains a high concentration of -glucans (> 35%) and mannan-oligosaccharides, MOS (~ 20%). Due to the processing conditions to which cells are subjected, the wall becomes denser compared to other yeast cell walls on the market. This yeast cell wall structure is resistant to degradation by digestive tract enzymes and bacteria, and its resistance to digestion in the gastrointestinal tract and fermentation in the large intestine are one of the main criteria for its use as prebiotic. Prebiotics are considered excellent contributors to animal health because they stimulate the immune system and contribute to intestinal mucosa integrity, prevent adhesion of enteropathogenic microorganisms, and have the ability to bind and inactivate mycotoxins in the intestinal lumen.
Mannan-oligosaccharide (MOS) is known for its ability to agglutinate pathogens. By providing a binding site for harmful bacteria present in the intestinal tract that have type 1 and 4 fimbriae, MOS prevents the colonisation of pathogens in the intestine. Since -glucans are not digested, trapped bacteria are excreted with faecal material. Importantly, to achieve full functionality, yeast cell walls must have low digestibility in the intestine. -glucans constitute the indigestible portion of the yeast cell wall so that the higher its concentration, the lower yeast cell wall digestibility.
-glucans are considered immunomodulators that improve immune response effectiveness and agility in animals. These polysaccharides are natural and effective stimulants of the innate immune system, and phagocytic cells, when in contact with -glucans, are stimulated, producing cytokines. Cytokine production provokes a chain reaction, improving animal immunity and allowing the body to fight opportunistic infections. One of these immune system reactions is the increased number of goblet cells responsible for mucus production. With increased mucus production and release in the intestinal lumen, the mucosa (villus protection barrier and the medium that allows the action of various enzymes) increases, providing greater protection to intestinal cells and villi.
Dietary nucleotide supplementation has been studied in several species, and although not considered essential nutrients, these additives play an important role in various metabolic processes and, in particular, in some body tissues and stages of animal life characterised by very high energetic demand due to high cell multiplication.
Free nucleosides and nucleotides can be immediately absorbed by enterocytes in the intestine, and are especially important for rapidly multiplying tissues and due to limited de novo synthesis (major nucleotide production pathway), such as intestinal epithelial cells, blood cells, hepatocytes and cells of the immune system. And this occurs especially in animals undergoing fast-growing stages (early stages), reproduction, stress, and challenges.
Hilyses is a great natural choice of exogenous free nucleosides and nucleotides, obtained through the processing of Saccharomyces cerevisiae yeast used in the fermentation of sugarcane to obtain ethanol. The process consists of cell autolysis (cell membrane rupture), where intracellular content is extravasated, and after this process, some specific enzymes are inserted for hydrolysis (breakdown) of RNA into nucleotides and nucleosides (which form the nitrogenous bases of the structure). This end product is highly digestible as it contains amino acids, peptides, and short-chain polypeptides and glutamine, and is highly recommended for animal nutrition. It also contains mannan-oligosaccharides (MOS, an effective tool against Salmonella and E. coli.) and high levels of -glucans (immunomodulators that stimulate the innate immune system for a faster and more effective response).
Supplementing diets with natural additives that provide support for animals to better respond to the challenges posed by the field is fundamental in farming systems. ImmunoWall and Hilyses act as prophylactic agents, increasing animal resistance, minimising contamination and high mortality rates, and improving weight gain and health. In highly challenging environments, such as in intensive animal production, strengthening the immune system is crucial for greater productivity gains.
See the original post:
Synergistic use of yeast-based products - All about feed
- Technion team discovers important adaptive strategy of the microbiome, impacting immune system - The Jerusalem Post - April 16th, 2024
- Targeting aging and age-related diseases with vaccines - Nature.com - April 16th, 2024
- Single cell analysis unveils B cell-dominated immune subtypes in HNSCC for enhanced prognostic and therapeutic ... - Nature.com - April 16th, 2024
- After the Smoke Clears: Scars on the Immune System - The Scientist - April 16th, 2024
- Exercise and the Immune System: What's the Latest Research? - Technology Networks - April 16th, 2024
- Analysis of immune cell infiltration characteristics in severe acute pancreatitis through integrated bioinformatics ... - Nature.com - April 16th, 2024
- Vaccination impairs de novo immune response to omicron breakthrough infection, a precondition for the original ... - Nature.com - April 16th, 2024
- Harnessing the power of the body's own cells to defeat cancer - Press Publications Inc. - April 16th, 2024
- Best Life: Immunotherapy targets brain cancer - Action News 5 - April 16th, 2024
- Dietary factors and their influence on immunotherapy strategies in oncology: a comprehensive review | Cell Death ... - Nature.com - April 16th, 2024
- New insights on B cells: Researchers explore building better antibodies and curbing autoimmune diseases - Medical Xpress - April 16th, 2024
- Immune cells' intense reaction to the coronavirus may lead to pneumonia - Science News Magazine - April 16th, 2024
- The telltale traces long Covid leaves in the blood - healthcare-in-europe.com - April 16th, 2024
- Overview of the Immune System - The Merck Manuals - March 18th, 2024
- SUNDAY Unraveling The Gut-Brain Connection: How Infant Gut Bacteria Shape Immune Resilience | TheHealthSit - TheHealthSite - March 18th, 2024
- Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics | npj Systems Biology and ... - Nature.com - March 18th, 2024
- Study unlocks the mystery of neonatal neutropenia in newborns - News-Medical.Net - March 18th, 2024
- Vertebral Subluxation and Systems Biology: An Integrative Review Exploring the Salutogenic Influence of Chiropractic ... - Cureus - March 18th, 2024
- A new strategy to attack aggressive brain cancer shrank tumors in two early tests - ABC News - March 18th, 2024
- Turning on the Bat Signal - The Scientist - March 18th, 2024
- Power Foods That Can Support Your Immune System - Videos from The Weather Channel - The Weather Channel - March 18th, 2024
- Report: Aggressive brain tumors respond to new, immune-focused therapy - UPI News - March 18th, 2024
- Designer immune-cell therapy could shrink deadly brain tumors, early trials show - Livescience.com - March 18th, 2024
- 20.2: Introduction to the Immune System - Biology LibreTexts - February 27th, 2024
- Can one shot of yoghurt really boost your immunity and gut health? - Daily Mail - February 27th, 2024
- New cancer therapy approved by FDA supercharges bodys immune system - The Washington Post - February 27th, 2024
- How bubonic plague rewired the human immune system - BBC.com - February 27th, 2024
- Innovative therapy targets and destroys leukemia stem cells - News-Medical.Net - February 27th, 2024
- Participate in Our Study for $100; Open Slots This Week - University of Arkansas Newswire - February 27th, 2024
- Sexual dimorphism during integrative endocrine and immune responses to ionizing radiation in mice | Scientific Reports - Nature.com - February 27th, 2024
- Comprehensive pan-cancer analysis identifies the RNA-binding protein LRPPRC as a novel prognostic and immune ... - ScienceDirect.com - February 27th, 2024
- YOUR HEALTH: The HAMR fights cancer - WAFB - February 27th, 2024
- Cycles of a diet that mimics fasting can reduce signs of immune system aging, as well as insulin resistance and liver fat - News-Medical.Net - February 27th, 2024
- How the powerhouse of the cell could be cancers Achilles heel - Freethink - February 27th, 2024
- Food is medicine: The science behind zinc and other supplements for immune health - Healio - February 27th, 2024
- Unleashing Our Immune Response to Quash Cancer - Medscape - February 27th, 2024
- Tumor histoculture captures the dynamic interactions between tumor and immune components in response to anti-PD1 ... - Nature.com - February 27th, 2024
- Converging and evolving immuno-genomic routes toward immune escape in breast cancer - Nature.com - February 27th, 2024
- Sanjula Jain Urges a Comprehensive Approach in Address Alarming Rise in Cancer Cases Among Younger Populations - Managed Healthcare Executive - February 27th, 2024
- Cystic fibrosis breakthrough points to zinc as infection buster - New Atlas - February 27th, 2024
- Exploring synergies between B- and T-cell vaccine approaches to optimize immune responses against HIVworkshop ... - Nature.com - February 27th, 2024
- Is the 100-year old TB vaccine a new weapon against Alzheimers? - The Guardian - February 27th, 2024
- Immune system in the blood of Alzheimer's patients found to be epigenetically altered - News-Medical.Net - February 10th, 2024
- What impact does exercise have on your immune system? And how to stay well while cycling - BikeRadar - February 10th, 2024
- Had COVID recently? Here's what to know about how long immunity lasts, long COVID, and more - AAMC - February 10th, 2024
- Noor Momin harnesses the immune system to treat heart disease | Penn Today - Penn Today - February 10th, 2024
- Research reveals a process tumors use to induce immune suppressor cells and evade immunotherapy - Medical Xpress - February 10th, 2024
- Immune targeting of HIV-1 reservoir cells: a path to elimination strategies and cure - Nature.com - February 10th, 2024
- Preventing severe allergic reactions with nanoparticles - National Institutes of Health (NIH) (.gov) - February 10th, 2024
- Sugary handshakes are how cells talk to each other understanding these name tags can clarify how the immune ... - The Conversation Indonesia - February 10th, 2024
- Scientists have identified an immune cell that can cause allergies - EL PAS USA - February 10th, 2024
- Sickle cell and the importance of the immune system - Punch Newspapers - February 10th, 2024
- Which cancers can be treated with immune checkpoint inhibitors? - MD Anderson Cancer Center - February 10th, 2024
- How does waste leave the brain? Washington University School of Medicine in St. Louis - Washington University School of Medicine in St. Louis - February 10th, 2024
- Healthy Kids: Give your immune system a boost to stay healthy this winter - nbc16.com - February 10th, 2024
- The impact of prior exposure to hypoglycaemia on the inflammatory response to a subsequent hypoglycaemic episode ... - Cardiovascular Diabetology - February 10th, 2024
- Impact of Chronic Stress on Immune System and Depression | Health News - Medriva - February 10th, 2024
- I tried 'swamp soup,' the viral recipe that promises to boost your immune system - Yahoo News - February 10th, 2024
- Understanding Immune Checkpoint Inhibition Therapy: Challenges and Strategies - Medriva - February 10th, 2024
- One Simple Change May Dramatically Boost The Effect of COVID-19 Vaccines - ScienceAlert - February 10th, 2024
- The gut virome is associated with stress-induced changes in behaviour and immune responses in mice - Nature.com - February 10th, 2024
- Cancer vaccines are in the works to fight BRCA-linked gene mutations - The Philadelphia Inquirer - February 10th, 2024
- What are the organs of the immune system? - InformedHealth.org - NCBI ... - January 17th, 2024
- Novel insights into the immune response to bacterial T cell superantigens - Nature.com - January 17th, 2024
- FDA signs off on Takeda's HyQvia as maintenance therapy for CIDP - FiercePharma - January 17th, 2024
- CBDs Pobezinsky and Pobezinskaya Use Flow Cytometry to Determine How Tumor Cells Outwit the Bodys Immune ... - UMass News and Media Relations - January 17th, 2024
- Boosting. What To Do. - Science Based Medicine - January 17th, 2024
- Axelia Oncology takes its TLR2/6 agonist into the clinic to harness the innate immune system - BioWorld Online - January 17th, 2024
- Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to ... - Nature.com - January 17th, 2024
- Opinion | Thanks to mRNA, Future Drugs Will Be Easier and Faster to Make - Mississippi Free Press - January 17th, 2024
- Elon research team models the COVID immune response, one equation at a time - Today at Elon - January 17th, 2024
- Are plant-based meals good for your immune system? 4 things to know about improving your health this week. - Yahoo Life - January 17th, 2024
- Scientists Find Key To Potential Breast Cancer Prevention, Treatment | Newsroom - UNC Health and UNC School of Medicine - January 17th, 2024
- What if every germ hit you at the exact same time? An immunologist explains - The Conversation - January 17th, 2024
- Why Don't We Have a Staph Vaccine? - Healthnews.com - January 17th, 2024
- Best ways to improve your immune system - The Business Standard - January 17th, 2024
- Stanford University researchers think future pandemics could be prevented with universal vaccines - KGO-TV - January 17th, 2024
- Why you may feel depressed and anxious when you're ill and how to cope with it - The Conversation - January 17th, 2024
- New mechanism with potential to boost checkpoint-blocking cancer immunotherapies identified - Medical Xpress - January 17th, 2024
- Battling Bugs and Blues: The Interplay of Infection and Emotion - News-Medical.Net - January 17th, 2024