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Archive for October, 2019

How Mere Humans Manage to Comprehend the Vastness of the Universe – Scientific American

Saturday, October 12th, 2019

Astrophysics is not typically considered to be part of the humanities. Yet one class I took as a senior at university suggested otherwise. It left me in awe of the human mind.

With my own background rooted in the humanities, I found myself focusing on the way my professors described the cosmos. While the fantastical environments of black holes, white dwarfs and dark matter often took center stage, at the heart of each discovery was the human mind seeking to understand the unfamiliar.

Their tales of discovery made it clear that we often take our knowledge of the universe for granted. After all, the universe was not built for the human mind to understand. When we look up at the night sky, we see only a tiny fraction of what is out there. It is the task of the astrophysicist to develop a picture of the universe despite our overwhelming blindness.

I wanted to better understand how being human shapes our understanding of the universe. After talking to some of Princetons leading astrophysicists, one thing became clear: the discipline requires the human mind to be conscious not only of the universe but of itself (unless otherwise identified, all quotes are from these scientists).

Only 5 percent of the universe is normal, observable matter. Within this small fraction, the human eye can only perceive matter that emits light within a certain frequency on the electromagnetic spectrum. While birds can perceive magnetic fields and snakes can image in the infrared, we can detect only visible light. This range determines our picture of space, Adam Burrows explains. Our picture of space is, in that sense, a direct product of the human mind.

Rather than assume our picture wholly captured the universe, Jo Dunkley says that astrophysicists started wondering whether there might be other things filling our galaxies and universe that we cannot see. They designed telescopes to detect frequencies of light that lie beyond human perception, such as those of x-rays and radio waves. With these instruments, our picture of the universe became 5 percent complete.

The astrophysicists task then became one of using the visible to detect the remaining 95 percent. Einsteins laws of gravity provided a means of navigating the obscure. Because gravity depends solely upon mass, its effects can be seen irrespective of light production. As Dunkley explains, a massive, invisible object, such as a black hole, will attract a visible object, like a star.

While the Event Horizon Telescopes image of a black hole is one recent example, the strategy dates back as early as 1933. It was Swiss astronomer Fritz Zwicky who unwittingly first employed the technique when examining the behavior of galaxy clusters. He found the clusters to be far more massive than anticipated based on what was visible. He called the missing mass dark matter. Nearly 40 years later, American astronomer Vera Rubin confirmed its existence. While measuring the radial velocity of galaxies, she observed velocities incompatible with those predicted by the laws of gravity. The expectation had been that objects farther from the center of the galaxy orbited more slowly than those near the center. Rubin instead observed a constant velocity, meaning that there was no decrease at the fringe of the galaxies. In order for this to be possible within the laws of physics, there must be more to space than meets the eye, Dunkley explains. The mass existed, it just had yet to be detected.

Neta Bahcall explains that its the laws of gravity that render this dark matter indirectly observable. They allow astrophysicists to determine how much of the universe is invisible without knowing exactly what the darkness is. James Jeans once likened the situation to Platos well-known allegory, where imprisoned in our cave, with our backs to the light, we can only watch the shadows on the wall. The comparison is apt. Counterintuitively, the shadows here represent what is visible, and the light represents what we cannot see or even imagine. With this technique, dark matter came to contribute 27 percent to our cave drawing of the universe.

The 68 percent of the universe absent from our drawing is still unknown. But, in 1998, that unknown was given a name: dark energy. It emerged as a means of explaining the universes anomalous expansion. In the 1990s, astrophysicists thought that the universes rate of expansion would gradually decrease. The laws of gravity predicted that the matter filling the universe would begin to pull itself together as time went on, thus slowing the universes expansion. Yet this turned out not to be the case. The expansion was accelerating. Very little is known about dark energy, and so our picture of the universe remains far from complete.

The problems facing our picture of the universe are not limited to what we can perceive. As Ed Turner explains, our mind and the culture in which it was formed condition the way we explore the universe. Because of this particular conditioning, we have mental blind spots for the cosmic phenomena that run counter to human intuition and understanding. For instance, Turner claims that the mind is predisposed to see things as statistically significant when they might not be. We erroneously perceive patterns in the spacing of stars and of the planets in the solar system, seeing them as though they were arranged.

There are other properties of the mind that get in the way of seeing the truth, according to Turner. Consider, for instance, our belief that massive objects must take up space. It is not a direct relationship: we accept that a piece of lead is more massive than a pillow, even though the latter is larger. At the extremes, however, we expect some positive correlation between the two. The extreme physical environment of a neutron star then poses problems. As Michael Strauss suggests, the star is so dense that a thimbleful of neutron star material has the mass of 70 million elephants. We cannot help but wonder: where is all the mass?

We are blinded by being human when we look at something larger than the human experience, Robert Lupton explains. It becomes further apparent when we are confronted with counterintuitive phenomena like white dwarfs and black holes. White dwarfs decrease in size as they become more massive, says Joshua Winn, and for black holes, all mass is compressed to zero size. While we cannot see the black hole, giving the phenomena a name allows us to imagine it. The same could be said of dark matter and dark energy, explains Dunkley. As with the previous analogy, language provides a means of overcoming our initial blindness to interact with these cosmic phenomena.

Astrophysicists encounter another blinding property of the mind when considering the nature of space: we can only visualize in three dimensions. In order to imagine the geometry of space namely whether it is flat or curvedwe would need to be able to think in four dimensions, says Dunkley. For instance, to determine the curvature of a ball, we first picture the ball in three dimensions. Therefore, to determine a three-dimensional curve, the mind would need to picture the four-dimensional object.

This need arises when astrophysicists contemplate the expanding universe and relativity. For the former, the task is to conceptualize a three-dimensional universe that exists in a loopan impossible visualization, for connecting every dimension would create a four-dimensional object. For the latter, in order to explore the relativistic behavior of spacetime, the task is to imagine a three-dimensional space deformed by gravityanother impossibility.

In both cases, two-dimensional analogies facilitate understanding. Dunkley likens the universe to a piece of string attached at both ends to create a loop, and then relies upon language to bridge the-dimensional gap. We would connect every side of space, such that no matter the direction we traveled in, we would always return to our starting point, she explains. Similarly, in his 1915 paper on general relativity, Einstein used a trampoline as a two-dimensional analogue for space. He then turned to language to illustrate how placing a massive object upon the stretchy surface creates a third, vertical dimension. The same principle applied in more dimensions, he argued: massive objects bend space. While we are still unable to visualize the four-dimensional phenomena, Dunkley says that through these linguistic analogies, we can imagine the consequences.

In this manner, astrophysicists stretch the mind to see the universe from an external perspective, says Turner. Burrows speaks of retraining the brain by developing a new language better suited for the conversation between the cosmos and the individual. The environment of the universe is so different from our daily environment that often we cannot imagine it, according to Joel Hartman. Take, for instance, the size of the universe and the number of stars within it. The language of mathematics, grounded in scientific notation, logarithms and orders of magnitude, allows us to grapple with the cosmos where words fall short, explains Burrows.

Similarly, when considering the four-dimensional universe, mathematical measurements provide astrophysicists with an invaluable means of navigating the obscure. Just like in two dimensions, explains Dunkley, if the geometry of space is flat, then parallel lines, like light rays, stay parallel always. If the space is curved, then they will either come towards each other in a positively curved universe or splay apart in a negatively curved one. To return to the language of Platos cave, it seems that by measuring the shadows before us, we are able to conceptualize, in part, the nature of what remains out of sight and out of mind.

Even with this universal language of mathematics, astrophysicists still resort to biological terms to describe certain cosmic phenomena. Turner describes how astrophysicists speak of the birth and death of stars, as though they were alive. More extreme is the twin paradox devised to facilitate a correct conception of time. We are accustomed to thinking of time as strictly linear and independent, but Einsteins theory of relativity says that probably is not the case. Time passes more slowly when close to massive objects.

To overcome our intuition, astrophysicists imagine taking two twins and somehow sending one of them to spend time near a black hole, [so that] she would actually age more slowly than [her] Earth-dwelling partner, explains Dunkley. The physical manifestation of aging allows the mind to grapple with the nonuniformity of time, for we are able to envision two differently aged twins despite the semblance of a paradox.

While there are certainly properties of the mind that get in the way of seeing the truth, as Turner says, the fact that it is human allows us to engage with the universe. The lives of stars and the twin paradox are just two examples of astrophysicists making sense of the unfamiliar through our own biology. After all, it is the mind of the astrophysicist that must first identify its blind spots and then devise techniques to overcome them. In that sense, astrophysics and humanism go together in a wonderfully unexpected way. As the literary critic Leo Spitzer once wrote, the humanist believes in the power of the human mind of investigating the human mind.

So often the predominant reaction to astrophysics focuses on how vast the universe is and how insignificant a place we hold in it. It would be far better to flip the narrative to see the marvel of the mind exploring the cosmos, human lens and all.

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How Mere Humans Manage to Comprehend the Vastness of the Universe - Scientific American

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Parents in UAE urged to check kids’ eyes to avoid preventable blindness – Khaleej Times

Saturday, October 12th, 2019

Medics recommend that all children have an initial eye exam before the age of four.

It is important to make sure children's eyes are checked for better school performance and to avoid preventable blindness that can only be treated during childhood, Abu Dhabi parents have been told.

On the occasion of World Sight Day (October 10), experts from the Cleveland Clinic Abu Dhabi's pioneering Eye Institute urged parents to arrange eye examinations for their children. Left uncorrected, impaired vision in children impacts quality of life, including lower academic achievement, and can result in permanent visual loss that is not treatable after childhood, an expert said as part of the 'Vision First!' programme.

The medics recommend that all children have an initial eye exam before the age of four. If parents suspect a child has an eye problem, they should be examined, whatever their age is. This allows causes of preventable blindness to be treated during childhood.

Dr Arif Khan, a paediatric ophthalmologist at Cleveland Clinic Abu Dhabi, has explained that a child's visual system is not set at birth. "It depends upon visual experience and continues to develop until the age of around seven or eight, with the first few years of life being a particularly critical period," he said. "At least four per cent of children have visual impairment that is only treatable during childhood. Detecting visual problems during childhood, when they are most amenable to treatment, can have a tremendously positive impact on the child's future."

While some paediatric eye conditions can be relatively easy for parents to spot, the majority can only be detected with an eye exam, particularly if the condition affects just one eye. There is a clear link between poor vision and lower academic performance in children. While most schools in the UAE provide eye exams for students, doctors are keen to highlight that waiting until a child has started school to correct some problems can be too late.

"It's important that people think about putting vision first. Children are never too young for an eye exam," said Dr Khan.

He said that he recently saw a child referred for a second opinion. The child was suffering from frequent headaches and blurred vision and had been diagnosed with neurological disease as the cause. A specialised eye examination revealed that the source of his symptoms was an undiagnosed need for glasses. After receiving the proper prescription glasses, the headaches stopped.

ismail@khaleejtimes.com

Ismail Sebugwaawo

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Parents in UAE urged to check kids' eyes to avoid preventable blindness - Khaleej Times

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One in 7 diabetics is visually impaired: Survey – BusinessLine

Saturday, October 12th, 2019

One in eight persons above 50 years in India is a diabetic; One in every 46 diabetics is blind; and one in seven has some form of impairment in their vision due to high blood sugar levels, according to a diabetes and diabetic retinopathy survey by the All India Institute of Medical Sciences (AIIMS) in collaboration with Ministry of Health and Family Welfare carried out between 2015 to 2019.

Of 56,771 persons over 50 years of age assessed in 21 districts, up to 11.8 per cent (6,717) were found to be diabetic. The highest prevalence of diabetes (over 20 per cent) was observed in Thrissur, Kerala (29.4 per cent), North Goa (24.7 per cent), Kapurthala in Punjab (22 per cent) and Virudhunagar in Tamilnadu (21.2 per cent).

Of the total diabetic population of 6,717 persons, 144 persons were blind and 923 persons were visually impaired. Prevalence of blindness among diabetics was 2.1 per cent and visual impairment 13.7 per cent, states the report.

In all the diabetics, 16.9 per cent had diabetic retinopathy or damage to retina, 7 per cent had diabetic maculopathy or damage to macula, a part of the eye which provides central vision, and 3.6 per cent had sight-threatening diabetic retinopathy, the report estimated. Globally, diabetic retinopathy is responsible for 1.06 per cent of blindness and 1.16 per cent of visual impairment, according to 2015 estimates.

The reason for diabetes leading to blindness and visual impairment was linked to poor blood sugar control among patients. While most of patients surveyed (85.7 per cent) were on oral tablets for diabetic management, only 39.5 per cent of known diabetics had controlled their random blood glucose to less than 200 mg per dL.

Up to 60.5 per cent had poor control of sugar. And a majority of the diabetics had never sought an eye check-up. Poor awareness regarding the health, 90 per cent of known diabetics had never gone for fundus evaluation for diabetic retinopathy, states the report.

In India, there are an estimated 7.296 crore cases of diabetes in adults. While urban prevalence is between 10.9 to 14.2 per cent, rural prevalence is between 3 to 7.8 per cent among population which is over 20 years and there is much higher prevalence in population over 50 years.

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One in 7 diabetics is visually impaired: Survey - BusinessLine

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Tears flow as 16-year-old girl sees light for the first time after 4 years of blindness – YEN.COM.GH

Saturday, October 12th, 2019

- Leticia Vidza, a 16-year-old girl from Cape Coast has had her eyesight restored after 4 years of blindness

- This followed a 30-minute surgery by a joint team of American and Ghanaian eye specialists

- Vidza benefited from a free cataract surgery project between the Himataya Cataract Project (HCP) and the Ghana Health Service (GHS)

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A 16-year-old girl identified as Leticia Vidza from Cape Coast, Central region, who was compelled to curtail her education after she lost her sight four years ago has had her vision restored.

Leticia Vidza underwent a 30-minute surgery performed by a combined team of American and Ghanaian doctors to remove a cataract from both eyes at the Cape Coast Teaching Hospital (CCTH).

The 16-year-old girl benefited from eye specialists performing free eye operations on some 600 patients with eye defects.

Vidza could not hide her joy with tears running down her cheeks at seeing once again after the plasters were taken off.

The elated girl told the Ghana News Agency (GNA) she would immediately resume school to continue with her education.

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Vidza recounted her predicament while revealing it all started in school when suddenly she could not see from afar.

She revealed that her ''parents did their best, sending me to hospitals but my condition worsened until I went totally blind. I am very excited and I cant wait to see my friends.''

The free cataract surgery initiative, is a joint programme between the Himataya Cataract Project (HCP), an American Non-Governmental Organisation, Ghana Health Service (GHS) and the CCTH is expected to benefit nearly 600 cataract patients in Cape Coast.

Dr Oscar Debrah, Country Representative of HCP, revealed more than 1,000 patients were screened in Cape Coast and its surrounding communities.

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Meanwhile, the resilience of Berdanette Adams, the wife of a former French footballer, Jean-Pierre Adams, has given meaning to staying true to one's vows which has resonated with many globally. Berdanette has reinforced what it means to stay with ones partner, for better or for worse.

Despite the current state of her husband, Jean-Pierre Adams, who is still in coma for nearly 40 years now, Berdanette continues to stay true to her love and has many marvelled.

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Tears flow as 16-year-old girl sees light for the first time after 4 years of blindness - YEN.COM.GH

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It’s No Coincidence That the Top Presidential Candidates Are All So Old – Mother Jones

Friday, October 11th, 2019

Over the past few months Bernie Sanders has often remarked that hes in great shape. I am blessed to have been in good health my entire life, he told the Washington Post earlier this year. I honestly cant remember the last time I missed work because of illness. I bought it: The guy seemed reasonably fit and sharp. Then, last week, he suffered a heart attack.

Given his age, its not all that surprisingabout a fifth of men in their 60s and 70s have heart disease; by age 80, nearly a third do. On Inauguration Day, he will be 79, which makes him 40 years older than the oldest of millennials, his most devoted demo. That also makes him the oldest serious contender, but many of his opponents arent spring chickens, either: Joe Biden will be 78, Donald Trump 74, and Elizabeth Warren 71.

This grayest-ever crop of frontrunner candidates has made some people wonder whether there should be a legal age limit on running for president. Indeed, other fields turn aging employees out to pasturecommercial airline pilots, employees of the United Nations, and judges in many states arent allowed to practice into their 70s. So isnt it conceivable that the presidency of the United Statesby many measures literally the hardest job in the worldshouldnt go to someone prone to senior moments? And if we have a lower age limit, why not an upper one?

Consider that Jimmy Carter, the oldest living president at 95, said recently, If I were just 80 years old, if I was 15 years younger, I dont believe I could undertake the duties that I experienced when I was president.

I recently called up some other accomplished older people to see what they thought about an aging president. Their responses were not exactly encouraging.

A 96-year-old museum docent barked, I have absolutely no interest in talking to you about that, and hung up.

The oldest mayor in the United Stateswho is 80 and runs the city of Stafford, Texastold me in an email that he would be happy to visit by phone but then never got around to calling me back.

An 87-year-old retired CEO said, Hold on, let me get out of my wheelchair. No, Im just kidding. Are you young and pretty? Will you go out with me? No, Im just kidding.

After that initial round of interviews, you can guess I wasnt exactly bullish about the idea of a president pushing 80. So I decided to check in with the experts: scientists who study how the aging process affects our bodies and minds. They painted a very different picture.

Nir Barzilai, an endocrinologist with Albert Einstein College of Medicine, studies the genes of a group of long-lived Ashkenazi Jews. Barzilaiwho is prone to comments like Age means nothing to me! and I know someone who just went to Machu Picchu for her 100th birthday!has been able to show that about 60 percent of the 100-year-old women hes studied have certain unusual mutations in their growth genes. We have discovered longevity genes, he said. Unfortunately, he then added, Do the candidates have them? I have no idea.

Short of sharing a full genetic sequencing, Barzilai says that family history is a pretty good predictive factor. That bodes well for Trump, Warren, and Biden, whose parents all lived well into their 80s. But then what to make of Sanders, who has already outlived both of his parents by several decades (and is expected to make a full recovery from his heart attack)?Barzilai acknowledges its not just about genes; social and environmental circumstances also help determine how long and how well a person lives.

I found out that more powerful predictors of both longevity and cognitive stabilitymore powerful than even geneticsare three external factors: education, race, and wealth. Countless studies have found a correlation between income level and lifespan; a 2016 study published in the Journal of the American Medical Association, for example, found that on average, the richest 1 percent of American men live 14.6 years longer than the poorest 1 percent; for women the difference is 10.1 years. Thats not surprising: Being wealthy means you have access to good health care and good control over your diet and exercise.

Relatedly, education level matters, tooand even more so along racial lines. In 2012, University of Illinois at Chicago gerontologist and public health researcher Stuart Jay Olshansky sorted deaths in the United States by age, race, and number of years of schooling. He found that on average, black men who hadnt finished high school lived 14.2 years less than white men who had completed 16 or more years of education; for women that figure was 10.3 years. (Its important to note that these racial differences probably have to do with lack of opportunity for African Americans, not any biological difference.)

Education also seems to have a strong protective effect against dementia: A 2018 University of Southern California study found that most people who have graduated from college can expect to prevent cognitive decline into their 80s, while people with a high school education often begin to experience it in their 70s. Its not that education actually prevents the changes in the brain associated with dementia, explained Joe Verghese, another Albert Einstein gerontologist. Rather, education seems to help people compensate for those changes. The theory is that people who are highly educated and intellectually engaged will be able to stave off the effects of this disease, he said.

When you consider these external factors, good genes dont seem as important. All of the presidential candidates are wealthy; all are exceptionally well educated. Take Sanders: Its valid to speculate that perhaps one reason he has lived so much longer than his parents is that he has a college degree and robust finances, while his parents were poor immigrants who worked all their lives.

University of Illinois Olshansky used actuarial tables to calculate the lifespan and healthspan of each candidatebasically, the risk that theyll die or become cognitively or physically disabled while in office. Taking into account wealth and education level he found that all the contenders stand at least a 76.8 percent chance of surviving their first term, most of them higher. (For most, the odds of living through a second term are also high, though for Sanders and Biden, they drop to 66 percent and 70 percent respectively.)

So its likely that by dint of privilege and circumstance, even the oldest contenders stand a pretty good chance of surviving the presidency. Fair enough. But that still left me wondering about their mental health and general with-it-ness. Would they, too, last?

The geriatric psychologists I talked to all assured me that contrary to popular belief, elderly people are no more prone to depression, anxiety, and other psychiatric disorders than their younger counterparts. Ellen Langer, a Harvard University psychologist who specializes in geriatric patients, railed against the stereotype of the socially weird old person. Its not that their age-addled brains make them behave strangely; rather theyve mastered the fine art of not caring. At 30 you might be mortified that you have spaghetti sauce on your shirt and you have to go a meeting, says Langer. At 70, you might say, Please excuse this, as you can see I was excited about the spaghetti I was eating!

In short, Langer says, life experience leads to perspective. And if you have those qualities, so what if you still think people listen to records? What are millennial staffers for, if not to show the president how to, say, use an iPad for briefing updates? (Speaking of millennials, maybe its time we rethink the requirement that a president must be at least 35, which hasnt changed since Continental Congress delegate Tench Coxe wrote that the president cannot be an idiot, probably not a knave or a tyrant, for those whom nature makes so, discover it before the age of thirty-five, until which period he cannot be elected. Today, you could probably figure all that out from a 25-year-old candidates Twitter feed. And we know people can act tyrannical across ages.)

In any case, the gerontologists told me that age wouldnt play a major role in their decision on Election Day. And their research suggests that setting a legal age limit for president probably doesnt make sensethough that may end up being irrelevant: The way things are looking now, Americans wont have much of a choice but to vote for someone who was born before there were zip codes or magic markers or antihistamines. Thats too bad, since there are signs that Americans are clamoring for younger, more diverse political leadershipsee, for example, the upwelling of enthusiasm for Alexandria Ocasio-Cortez and her squadmates. And last year, when I was talking to voters about the 44-year-old African American Georgia gubernatorial candidate Stacey Abrams, I heard over and over from people who were thrilled to see a candidate that finally looked like them.

In this country, the same set of extreme social privileges that propel someone to the position of frontrunner presidential candidate also protect against the typical ravages of old age. And that single fact, for better or worse, is a stronger predictor of candidates health than any senior-moment gaffe they might have over the coming months. Its entirely possible, Olshansky told me, that some of these folks running for president are super-agers. We should all be so lucky.

Image credit, from left:Bill Clark/Getty; Mario Tama/Getty; Chip Somodevilla/Getty; Joe Raedle/Getty

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It's No Coincidence That the Top Presidential Candidates Are All So Old - Mother Jones

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What Will It Take for Eliud Kipchoge to Break 2-Hours? – runnersworld.com

Friday, October 11th, 2019

In his all-conquering career, its the final, elusive frontieran impossible dream that Eliud Kipchoge will now try to make a reality.

The 34-year-old has done it allOlympic gold, world title, the marathon world recordbut there is one thing he has yet to tick off his bucket list: a sub-two-hour marathon.

Many ideologies [have] been going that no human will break the two-hour mark but personally, I have dared to try, Kipchoge said in a video of the INEOS 1:59 Challenge documentary series. I am doing it to make history.

He is, without question, the greatest marathoner of all time, but in a park in Vienna, Austria, on Saturday, Kipchoge will aim for immortality. The start time for the event will be 8:15 a.m. in Vienna; 2:15 a.m. ET.

Fans know that he has come close before. In May 2017, the Kenyan clocked 2:00:25 on a formula one racetrack in Monza, Italy, during Nikes Breaking2 project. It was the fastest marathon ever run, but did not count as an official world record because of the use of rotating pacemakers.

Kipchoge went on to set the official world record at last years Berlin Marathon, running 2:01:39 to carve 78 seconds off the previous mark. Shortly after winning his 10th straight major marathon in London this past April, he announced his next project: the INEOS 1:59 Challenge.

In his bid to push back the boundaries of human ability, he thinks hell have more than luck on his side. I have a rich experience from Monza, he said. I am confident I will beat the mark.

Many of the people close to Kipchoge are as confident as he is. His manager, Valentijn Trouw, has overseen his preparation. In an interview with Runners World on Wednesday, he said Kipchoge is primed for the task.

If we look at the whole training circle and compare it with preparations for London (in 2019) or Berlin (in 2018), he is in a nice position, Trouw said.

I am confident I will beat the mark.

Trouw paid several visits to Kipchoge as he trained for the attempt in Kaptagat, Kenya, and having been there for every step of Nikes Breaking2 project, he sees a difference in Kipchoges mindset this time.

Two years ago he was training his mind for seven months to convince himself he could do it. The moment we talked about this, Eliud had that internal feeling: If I train well and it all comes together on the day, Im going to do it.

No stone has been left unturned in preparation. With the financial backing of INEOS, a petrochemical company owned by the richest man in Britain, Jim Ratcliffe, every detail has been orchestrated to maximize Kipchoges chances.

The coursethe Prater park in Viennawas picked after a worldwide search using software to find locations that have ideal parameters in temperature, humidity, air pressure, wind speed, elevation, and precipitation at this time of year.

The race is scheduled to begin early on Saturday on the citys Reichsbrcke Bridge, and Kipchoge will then make a 1.2K run to the Praterstern roundabout, where the road has been resurfaced with a camber to maximize Kipchoges efficiency as he circles it.

The initial run to the park features an elevation drop of 16 meters and once there, Kipchoge will complete four laps of a 9.6K circuitand a final stretch to complete the full distancethat is almost completely flat, with just 2.4 meters of elevation change. After the four circuits,

Forty-one world-class distance runners have been recruited as pacemakers, and they will take turns in a different formation to that seen in the previous attempt. Five athletes will run in front of Kipchoge in a V-shape, with two athletes just behind him to either side, which was found during testing as the most efficient way to reduce drag. Officials from INEOS noted that Kipchoge and all the pacers are being tested both in and out of competition by the Athletics Integrity Unit (AIU), which is the same testing unit used by the World Marathon Majors.

The time Kipchoge runs will again not count as an official world record because of the use of rotating pacemakers and because he will be handed drinks from a bicycle rather than from a table, as required by the sports governing body (IAAF) for record-eligible races.

However, all other IAAF guidelines will be followed to ensure the achievement, if it happens, maintains a sense of credibility.

While Nikes attempt was not open to the public and took place on a near-deserted racetrack, this event is supposed to be the opposite, with organizers hoping close to 20,000 will line the roads in The Prater to lend their support.

Having a crowd is absolutely crucial, giving him that encouragement, bringing that energy, said Fran Millar, CEO of Team INEOS, in one of the documentary videos leading up to the event. Its going to be a huge boost for Eliud.

A car will once again be driven in front of the runners at a controlled pace of 2:50 per kilometer (4:33 per mile), with a line projected on the road for runners to follow.

During the race Kipchoge will consume a carbohydrate drink made by Maurten, a Swedish manufacturer, and every time he takes a drink from a bottle and discards it, it will be picked up and weighed to measure exactly how much was consumed, with feedback given to guide future intake.

The biggest performance gain, however, may come from Kipchoges shoes. Its a controversial topic in running given the slew of records that have fallen since Nike introduced its Vaporfly 4% during its Breaking2 attempt in 2017. The shoe features a carbon fiber plate to help propel athletes forward, and in April this year Kipchoge wore its latest version, the ZoomX Vaporfly Next%, which was 15 grams lighter and featured a thicker midsole.

In recent months, Kipchoge has been training with a new version of the shoe, which is set for release next year. It will be mainly a follow-on from the shoe he was using in Berlin and London, Trouw said. He has done quite a lot of training sessions in the shoe to get familiar.

At the time of publication Nike had not responded to questions about the shoes specifics, but an industry insider has told Runners World it is substantially more efficient than both previous editions.

Of course, the most important ingredient of all will be Kipchoges fitness. After the London Marathon in April he ran easy for four days and then took three weeks completely off running. For the next month he ran three to four times a week and hit the gym for two and a half hours on the other days, doing weight training, step aerobics and flexibility work.

That laid the foundation for what came next, with Kipchoge then following his usual four-month marathon buildup under the guidance of Patrick Sang, the coach and mentor who has steered his career for the past two decades.

Courtesy of INEOS 1:59 Challenge

Kipchoge typically ran a fartlek on Tuesdays, a long run on Thursdays and a hard session of intervals on Saturdays, with the rest of his week filled with easy to steady running.

A test event was organized in Vienna in late August, and while the plan was initially for Kipchoge to attend and familiarize himself with the course, he decided it was better to stay in Kenya and avoid the interruption to his training.

As a result he got his first look at the course on Tuesday after arriving in Vienna, where the 41 pacers have been practicing their formations all week. One of those is U.S. 1500-meter athlete Matthew Centrowitz, who spoke in glowing terms about Kipchoge at this years world championships.

Hes got the most unbelievable range of any athlete ever, Centrowitz said. We could all learn a little something from him about his longevity, the enjoyment he looks like he has even when hes struggling out there. If [he makes] history, thats something I want to be a part of.

Fellow Olympian Lopez Lomong was part of the pacing team during Nikes Breaking2 attempt, and the U.S. distance star is equally impressed by Kipchoge. Hes a very calm guy, dialed in, Lomong said. Theres a lot of things I like to emulate from him, how humble he is. He doesnt do it for himself, he does it for the community, to open the eyes of athletes that if he can do it, then we can do it as well.

Lomong is certain Kipchoge will achieve his goal, predicting a finishing time of 1:59:36, while Centrowitz is also confident, predicting 1:59:52.

As with all great sporting barriers, much of the challenge is mental. In that department, few can rival Kipchoge.

From my experience over many years he can block pain, put it at the back of his mind until the race is done, Kipchoges long-time physiotherapist Peter Nduhiu said in a documentary video showing his training. Its something that is so unique to him.

Kipchoges mental strength is something he takes seriously. He devours self-help books for ways to find a psychological edge.

Some people think its genetics, that you either have a strong mind or you dont, but its something you can train and improve, Trouw said. This is where day in, day out, Eliud gets stronger and stronger.

Trouw has been with Kipchoge in Vienna since Tuesday, and while he is cautious not to make any bold predictions, he sees in his star athlete as having a calm, cool confidence that bodes well as he prepares to go up against the ultimate barrier.

Eliuds mindset at the moment is really strong, Trouw said. He absolutely believes he is going to do this.

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Analysis on the Global DNA Read, Write & Edit Market, 2017-2019 and Forecast to 2024 – Yahoo Finance

Friday, October 11th, 2019

DUBLIN, Oct. 10, 2019 /PRNewswire/ -- The "Global DNA Read, Write and Edit Market" report has been added to ResearchAndMarkets.com's offering.

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The scope of the report includes DNA read, write and edit technologies, applications, industries, initiatives, patents, and companies. The markets for read, write and edit products and services are given for 2017, 2018, 2019 (estimated) and 2024 (forecast).

This report reviews the main read, write and edit technologies and explains why genetic variation is important in clinical testing and disease. It then discusses significant large-scale research initiatives that impact read, write and edit applications. Of particular interest is a discussion of population-scale sequencing projects throughout the world, and their likely impact. The main market driving forces for read, write and edit products and services are listed and discussed.

The report quantifies each of the main market segments. The read (sequencing) market is quantified by delivered format, including sequencing workflow products (sample preparation kits and reagents, sequencing instruments and consumables, and informatics) and sequencing services (clinical diagnostics and sequencing services to applied market customers).

The sequencing workflow products market is quantified by type, that is, DNA isolation and extraction; target enrichment; library preparation; and informatics/ecosystems. The sequencing instruments and consumables market is given by platform (Sanger, NGS, and 3GS).

The sequencing services market is analyzed by end-user application (applied, clinical, and R&D). Within sequencing services, the applied market is analyzed by end-user application (agriculture, biopharma, consumer, microbiology, population-scale genomics, synthetic biology and other).

Also within sequencing services, the clinical market is analyzed and quantified by disease category (cardiovascular, clinical microbiology and infectious diseases, Mendelian disorders, metabolic/immune disorders, neurology, oncology, reproductive health, and transplant medicine).

The DNA write (synthesis) market is quantified by product type (oligonucleotides, synthetic biology parts, genes, and RNA therapeutics). The oligonucleotide market is analyzed by application (gene editing, sequencing, PCR, FISH, microarray, gene synthesis and other). The gene market is quantified by gene type (standardized, value-added). Finally, the RNA therapeutics market is quantified by platform (RNA interference, antisense oligos, micro RNA modulation, and mRNA) and by disease category (cancer, hematology, musculoskeletal, neurology, and rare diseases).

The DNA edit (gene editing) market is quantified by application (agriculture, biopharma, diagnostics, and therapeutics); editing platform (CRISPR, meganuclease, TALEN, ZFN). The gene-editing agriculture market is analyzed by product type (crop/seeds, livestock). The gene-editing biotechnology market is analyzed by product type (kits and reagents, cell line engineering, animal models and services). The gene-editing therapeutics market is analyzed by disease category (eye and rare diseases).

Specific geographic markets discussed include North America, Europe, Asia-Pacific, and the rest of the world (ROW).

Industry sectors analyzed include next-generation sequencing; long-read sequencing; DNA synthesis; RNA therapies; and gene editing.

More than 320 companies in the read, write and edit industry are profiled in this report.

The author also provides a summary of more than 180 of the main industry acquisitions and strategic alliances that took place from January 2018 through June 2019, including key alliance trends.

Story continues

Market Summary

The DNA read, write and edit industry is at the beginning stages of its growth story; penetration of the key markets is still at an early stage. The data indicates that there is a significant future upside for sequencing across research, metagenomics, agriculture, synthetic biology, and clinical applications, among others.

The situation is similar for DNA writing and editing technologies, with clinical therapeutic applications, in particular, providing an enormous total available future market that is yet to be significantly penetrated. Major successes in this industry include the adoption of next-generation sequencing (NGS) for noninvasive prenatal testing; enabling the roles of synthetic DNA oligonucleotides and genes in the rise of the synthetic biology industry; and rapid adoption of CRISPR gene editing by research institutions and biopharma industries.

There is increasing interplay among the three DNA technology platforms, giving rise to innovative corporate strategies. For example, Arbor Biotechnologies employs sequencing, gene synthesis, and artificial intelligence to perform high-throughput discovery of biomolecules, including new CRISPR proteins.

Report Scope

Key Topics Covered

Chapter 1 Introduction

Chapter 2 Summary and Highlights

Chapter 3 Overview

Chapter 4 Technology Background

Chapter 5 DNA Read, Write and Edit Initiatives

Chapter 6 DNA Read, Write and Edit Applications

Chapter 7 DNA Read, Write and Edit Industries

Chapter 8 Acquisitions and Strategic Alliances

Chapter 9 DNA Read, Write and Edit Markets

Chapter 10 Patents

Chapter 11 Nucleic Acid Read, Write and Edit Company Profiles

Companies Mentioned

For more information about this report visit https://www.researchandmarkets.com/r/7jlxd8

Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research.

Media Contact:

Research and Markets Laura Wood, Senior Manager press@researchandmarkets.com

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Antibiotics bug the immune response – Science

Friday, October 11th, 2019

Abstract

Changes in the gut microbiome caused by antibiotics can impair immune responses to influenza vaccination.

Many facets of the immune system have been shown to be affected by the bacteria that live on us and within us. However, the mechanisms of these effects remain unclear, especially in human immunology. Prior investigations highlighted the potential impact of commensal microorganisms on vaccine responses but have left many questions. Hagan et al. recruited a cohort of healthy adults (n = 22) and vaccinated for influenza (on day 0). Half of the participants were pretreated with antibiotics (day -3day 1). Hagan et al. measured the effect of antibiotics on gut microbiome with a stool 16S rRNA sequencing time course. Antibiotics led to a significant decrease in stool 16S rRNA and lipopolysaccharide stool (proxies for microbiome content in the stool) and altered microbiome community members; these recovered slowly. There was not a significant impact of antibiotics on influenza responses. This cohort had high baseline influenza titers, so Hagan et al. recruited a second group with 11 additional participants with low baseline influenza titers. This cohorts antibiotic-treated group again showed a decrease in microbial quantity and diversity but also showed a decrease in immunoglobulin G1 (IgG1) and IgA against one of three influenza strains. There was no clear impact on proportions of B cell subsets or T follicular helper cells. Antibiotic treatment alone yielded increases in inflammatory pathways and decreased serum secondary bile acids. Systems analysis of the entire dataset highlighted connections among the microbiome, levels of related metabolites (i.e., secondary bile acids decreased with antibiotic treatment), the subsequently increased inflammatory response (e.g., AP-1), and impact on vaccine responses. H1N1-specific IgG1 titers and secondary bile acids were both affected by the altered gut microbial community post-antibiotics, although seemingly by separate mechanisms. Continuing to delineate connections among the microbiome, metabolome, and immune response in additional, larger cohorts is fundamental to moving toward a mechanistic understanding of the impact of the microbiome on the immune system. Beyond that, given the durable impact of initial influenza exposure on subsequent influenza immune responses, it will be fascinating to study these questions in children, especially in infants before initial influenza vaccination.

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Women have a more effective immune system than men – Research – All4Women

Friday, October 11th, 2019

JERUSALEM, Oct. 10 (Xinhua) Israeli researchers found differences between females and males immune systems, which may explain why women are less ill than men, the Ben Gurion University (BGU) in southern Israel reported Thursday

The findings, published in the journal Nature Communications, may lead to accurate prevention, diagnosis and treatment of illnesses, with personalisation and reference to the patients gender. Men and women differ in many genetic, physiological, and social traits, but most body systems, except the reproductive system, function quite similarly.

In the study, the BGU researchers used gene expression data from 11 types of immune cells from male and female mice. Surprisingly, in one of the cell types, called macrophage, significant differences between males and females were found.

The main difference was in genes associated with interferon protein response in females, compared with males. This finding indicates some immune activity in these cells, only in females. The results suggest that the activity of the female immune system defends faster and more strongly against infectious agents.

While men tend to have infectious diseases more frequently and severely, womens immune response is stronger, and they recover better from injuries and live longer. On the other hand, this pre-activity also increases the likelihood of an over-reaction that may lead to autoimmune diseases, where immune system failure causes immune cells to attack cells in different body systems.

While All4Women endeavours to ensure health articles are based on scientific research, health articles should not be considered as a replacement for professional medical advice. Should you have concerns related to this content, it is advised that you discuss them with your personal healthcare provider.

Author: ANA Newswire

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This claim about the flu shot is all wrong – MarketWatch

Friday, October 11th, 2019

Flu vaccination prevents millions of flu-related illnesses and deaths annually, but vaccination rates are low for many reasons.

During the 2018-2019 flu season, the Centers for Disease Control and Prevention reported that about 45% of U.S. adults received the flu vaccine. While this is an increase of 8 percentage points from 2017-2018, it falls way below the national goal of 70% of American adults receiving a flu shot.

One of the common myths that leads people to avoid the flu shot is that they think the shot will give them the flu. But that is simply not true. The virus in the vaccine is not active, and an inactive virus cannot transmit disease. What is true is that you may feel the effects of your body mounting an immune response, but that does not mean you have the flu.

I am a nursing professor with experience in public health promotion, and I hear this and other myths often. Here are the facts and the explanations behind them.

Influenza, or the flu, is a common but serious infectious respiratory disease that can result in hospitalization or even death. The CDC estimates that during a good flu season, approximately 8% of the U.S. population could get the flu. That is roughly 26 million people.

Each year the flu season is different, and the flu virus also affects people differently. One dangerous complication of the flu is pneumonia, which can result when your body is working hard to fight the flu. This is particularly dangerous in older adults, young children and those whose immune systems arent working well, such as those receiving chemotherapy or transplant recipients.

Historically millions of Americans get the flu each year, hundreds of thousands are hospitalized and tens of thousands of people die from flu-related complications. During the 1918 flu pandemic, one-third of the worlds population, or about 500 million people, were infected with the flu. Since that time, vaccine science has dramatically changed the impact of infectious diseases.

The cornerstone of flu prevention is vaccination. The CDC recommends that everyone 6 months of age and older who does not have contraindications to the vaccine, receive the flu shot.

And just as the polio vaccine wont give a child polio, the flu vaccine will not cause the flu. Thats because the flu vaccine is made with inactive strains of the flu virus, which are not capable of causing the flu.

That said, some people may feel sick after they receive the flu shot which can lead to thinking they got sick from the shot.

However, feeling under the weather after a flu shot is actually a positive. It can be a sign that your bodys immune response is working. What happens is this: When you receive the flu shot, your body recognizes the inactive flu virus as a foreign invader. This is not dangerous; it causes your immune system to develop antibodies to attack the flu virus when exposed in the future. This natural immune response may cause some people to develop a low-grade fever, headache or overall muscle aches. These side effects can be mistaken for the flu but in reality are likely the bodys normal response to vaccination.

And the good news is these natural symptoms are short-term side effects compared to the flu, which can last much longer and is more severe. It is estimated that less than 2% of people who get a flu shot will develop a fever.

Also, people often confuse being sick with a bad cold or stomach flu with having influenza. Influenza symptoms can include a fever, chills, sore throat, runny or stuffy nose, body aches, fatigue and headaches. Cold symptoms can be similar to the flu but are typically milder. The stomach flu, or gastroenteritis, can be caused by several different bacteria or viruses. Symptoms of gastroenteritis involve nausea, vomiting and diarrhea.

Some people do get the flu after they have received a flu shot, but that is not from the shot. It can happen for a couple of reasons.

First, they could have been exposed to the flu before they had the shot. It can take up to two weeks after receiving the flu shot to develop full immunity. Therefore, if you do get the flu within this period, it is likely that you were exposed to the flu either prior to being vaccinated or before your full immunity developed.

Second, depending on the strain of the flu virus that you are exposed to, you could still get the flu even if you received the vaccine. Every year, the flu vaccine is created to best match the strain of the flu virus circulating. Therefore, the effectiveness of the flu vaccine depends on the similarity between the virus circulating in the community and the killed viruses used to make the vaccine.

If there is a close match between the two, then the effectiveness of the flu vaccine will be high. However, if there is not a close match, vaccine effectiveness could be reduced. Still, it is imperative to note that even when there is not a close match between the circulating virus and the virus used to make the vaccine, the vaccine will still lessen the severity of flu symptoms and also help prevent flu-related complications.

Bottom line: You cannot get influenza from getting the flu vaccine. As someone who has treated many people who do get the flu, I strongly urge you to get the shot.

Now read: Flu season 2019 looks bad so fight it with these 10 proven treatments

Libby Richards is an associate professor of nursing at Purdue University in West Lafayette, Ind. This was first published by The Conversation Why the flu shot cannot give you the flu (and why you should get one now)

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Bronchiectasis Severity Linked to Pregnancy-related Protein, Study Finds – Bronchiectasis News Today

Friday, October 11th, 2019

A protein associated with pregnancy is linked to disease severity and frequent exacerbations in people with bronchiectasis and chronic chest infections (that are mostly caused by Pseudomonas aeruginosa), a study suggests.

Bacteria could be hijacking a bodys natural process to shield themselves from the immune system, and persist in the airways, according to researchers at the University of Dundee. Therefore, approaches that boost the immune system could be successful against chronic respiratory infections, the team said.

The data were presented at the recent European Respiratory Society (ERS) 2019 International Congress, in Madrid, and described in the study Pregnancy Zone Protein is Associated with Airway Infection, Neutrophil Extracellular Trap Formation and Disease Severity in Bronchiectasis, which was published in the American Journal of Respiratory and Critical Care Medicine.

Pregnancy zone protein (PZP) is a powerful inhibitor of the immune system. It is produced by men and women but its blood levels are higher during pregnancy, when it is believed to suppress the immune system to protect the fetus from being rejected.

Although work in mice suggested that PZP increases susceptibility to viral infections, the protein has not been reported in the airways or studied in chronic respiratory disease.

People with chronic lung diseases are far more likely to get regular chest infections. Despite this fact, we find that the bodys normal mechanisms for dealing with infection doesnt work properly in those situations, which leaves patients trapped in a vicious cycle of coughing and spluttering from frequent chest infections, James Chalmers, PhD, professor at the University of Dundee and lead author of the study, said in a university news release, written by Grant Hill.

To investigate whether PZP could be associated with airway infections in bronchiectasis and other lung diseases, the researchers took samples from 124 people with bronchiectasis and 40 patients with chronic obstructive pulmonary disease (COPD), and analyzed the concentrations of PZP in their sputum (coughed-up mucus) and blood.

They found that PZP was present in sputum samples from people with COPD or bronchiectasis and those with chest infections, but not in healthy people.

Also, higher levels of PZP in the sputum were correlated with bacterial infections, mainly caused by P. aeruginosa.

Higher sputum PZP levels also correlated with greater disease severity, more frequent infections, reduced lung function, and quality of life as assessed by the Quality of Life Bronchiectasis Respiratory Symptom Score and with a higher amount of bacteria in the airways.

Consistent with these observations, treatment withantibiotics reduced PZP production in the airways of patients with bronchiectasis and chest infections.

A more detailed analysis revealed that a type of white blood cell, called neutrophils, was responsible for the release of PZP in the airways of patients.

In response to infections and other triggers, neutrophils launch a defense system called neutrophil extracellular traps (NETs), which can immobilize invading microorganisms. In vitro experiments showed that neutrophils alsorelease high concentrations of PZP, and confirmed the presence of this protein within NETs.

We report a novel link between airway infection, NET formation, and disease severity in bronchiectasis during chronic airway inflammation, the researchers wrote.

We were surprised to find PZP in the lungs, but this might explain why people with chronic lung disease cannot clear these infections easily. We believe that the bacteria are hijacking the bodys natural processes during pregnancy, activating the production of PZP, and shielding themselves from the immune system, Chalmers said.

These findings present a new opportunity to treat those people with the most severe types of chest infection, by kickstarting the bodys natural defense mechanisms, and helping break the vicious cycle of chest infections, he added.

Ana is a molecular biologist enthusiastic about innovation and communication. In her role as a science writer she wishes to bring the advances in medical science and technology closer to the public, particularly to those most in need of them. Ana holds a PhD in Biomedical Sciences from the University of Lisbon, Portugal, where she focused her research on molecular biology, epigenetics and infectious diseases.

Total Posts: 52

Patrcia holds her PhD in Medical Microbiology and Infectious Diseases from the Leiden University Medical Center in Leiden, The Netherlands. She has studied Applied Biology at Universidade do Minho and was a postdoctoral research fellow at Instituto de Medicina Molecular in Lisbon, Portugal. Her work has been focused on molecular genetic traits of infectious agents such as viruses and parasites.

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How nutrition can fight colds and flu – The Leader

Friday, October 11th, 2019

Shana Tatum

By Shana Tatumstatum@wellness-collaborative.com

As we begin the fall season, pumpkin spice flavors are not the only thoughts that fill our mind. Cold and flu season may preoccupy our attention as well.

Most know the dread we feel when that scratchy throat or the drippy nose symptoms appear. It can slow us down and put a kink in our day-to-day activities. However, just as most of the points shared here in this column, there are many preventive measures to take to avoid having a season filled with colds or the flu.

If you are a regular reader of The Leader, you know I put great weight on good sleep hygiene. Practicing this nightly sets you up for a stronger immune response. In fact, recent research shows that during sleep, certain parts of the immune system are activated. One study demonstrated that people sleeping seven hours per night were shown to be 200 percent more likely to catch a cold than those who slept eight hours per night. Good, long sleep is of high importance, especially if a cold has already begun.

In addition to good rest, there are some foods that are beneficial to include in the diet to enhance the immune system.

Old-fashioned chicken soup

Its the kind our grandmothers made. Hydrating broth made with chicken bones contain amino acids rich in glycine, proline, lysine, alanine, arginine and valine. Soups like this provide needed protein and hydration during times of healing. Minerals and vitamins found in carrots, celery and onion further support the immune system in intervals of illness. Old-fashioned chicken soup also is an easily digestible soup.

Garlic

Long known for its antimicrobial properties, garlic (allicin) can help fight against infection, reduce inflammation and even may be a guard against tumor formation. Its use dates back to 400 BC and has been used by many cultures worldwide. It is a common ingredient in much of todays cooking.

It can be used minced or roasted whole in recipes for added flavor. If using garlic in your cooking is new for you or you fear the dreaded garlic breath, start slow. Add whole cloves to soups or stew-like meals. You may also find garlic in the refrigerated produce section pre-minced and in a jar.

As a health remedy, add the juice of one lime, a cup chopped onion, 1-2 cloves of minced garlic and cup water in a blender. Mix well and drink daily when cold-like symptoms appear.

Foods rich in Vitamin C

Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin. Foods high in Vitamin C act as an antioxidant to combat stress in the body. It is an immune booster and a key ingredient to include in your medicine pantry. It serves as a main structural protein of skin, cartilage and blood vessels and is rapidly depleted with physical and emotional stress.

If taken regularly before a cold strikes, it has been shown to reduce the duration of the virus.

Examples of foods rich in Vitamin C include orange and tomato juice, red bell peppers and strawberries.

Ginger

Ginger belongs to the family Zingiberaceae. Through a recent boating adventure in Kauai, I saw firsthand how ginger helps ease motion sickness. Sailors for generations have praised its properties and distant cultures have employed the root for the immune-boosting benefits. With much of the immune system housed in the digestive tract, it is no mystery that gut and immune health may both see improvements with the powerful flavorings of ginger.

An easy ginger tea can be made with boiled water, ginger root, lemons and raw honey.

Thankfully, Mother Nature provides much of the immune system support we need every day. Whether it is the powerful phytonutrients and antioxidants found in fruits and vegetables or the inflammation-reducing compounds found in herbs and spices, we can look to our daily meals to fully nourish us.

By getting good nightly sleep, avoiding excess alcohol and managing daily stress, be it physical or emotional, we can strike a balance that supports optimal wellness and keeps illness at bay. My hope is that you try some of these tips to stay well this cold and flu season.

To your health!

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I Didn’t Bond With My Baby Right Away – NYT Parenting

Friday, October 11th, 2019

The writers husband with their baby girl.Creditvia Jancee Dunn

When I was pregnant, my husband and I made a habit of fondly addressing my growing belly. As obsessive first-time parents, we had read the research that bonding with your baby is linked to everything from a more robust immune system to deeper infant sleep to better cognitive and emotional development. We reasoned that it couldnt hurt to start the process while she was still in the womb. As she grew bigger, I fancied that when I talked to her, she moved around more enthusiastically. Were communicating! Already, we have a mystical connection!

I longed to meet her. I counted the days.

As is so often the case, things didnt go as planned during delivery starting with the doctors discovery that the umbilical cord had snaked around the babys neck, requiring an emergency C-section.

[Read our guide on what to expect from a Cesarean section.]

I wasnt at all prepared for the intensity of the operation the tugging, the cutting, the jets of blood onto the protective sheet. In a daze, I heard my daughter cry for the first time.

A smiling nurse materialized. Do you want to hold her? she asked.

I blinked at her. Not really, I thought. My adrenaline was surging. The brightly lit operating room was jammed with people. My body was shaking uncontrollably (a common occurrence, although researchers dont yet know the precise cause).

All I wanted to do was lurch off the operating table and hide somewhere.

I cant do it, I croaked.

The nurse nodded, and put Sylvie into the eager arms of Tom, who fell swooningly in love.

As I recovered in the hospital and then returned home, I expected that at any minute, my maternal feelings would flow, and wed resemble the enraptured moms and babies I saw in diaper cream ads.

Instead, for the first few weeks, I felt the same fuzzy disconnect as I held and fed her. When I brought this up with our pediatrician, she ran through the symptoms of postpartum depression constant crying, feelings of dark dread and hopelessness that impede your ability to care for the baby and determined I didnt have it. Still, I felt steeped in shame and guilt.

[How to recognize and seek treatment for postpartum depression]

Its time for moms to let that go, said Dr. Susan Lareau, M.D., assistant professor of obstetrics and gynecology at Magee-Womens Hospital at the University of Pittsburgh Medical Center. Some people feel an amazing, instant connection, and some think, Huh, theres a baby, she said. And thats O.K., too. We see this a lot in the hospital. Many women just need the first few hours, or days, to recover, be it a C-section or a difficult vaginal delivery. Theyre too tired to think of anything other than I want to go to sleep.

However one arrives at parenthood, from adoption to surrogacy, those feelings are normal, said Dr. Alexandra Sacks, M.D., a New York City reproductive psychiatrist. The process of becoming a mother, she said, is profound and exhilarating and triggering and a million different things that are nuanced for people.

A small but notable 2014 study published in the journal BMC Pregnancy and Childbirth revealed that distress states among new mothers feelings of detachment and the shock of the new were less severe than postpartum depression but were nonetheless difficult. In a 2018 meta-analysis, Norwegian researchers found it was common for mothers to have a gap between expectations and reality, and the sense of detachment from the child, and ensuing guilt and shame.

But the societal pressure to instantly adore your offspring is intense. Dr. Sacks ticked off a few factors that shaped my delivery room experience, among them how you relate to pain, how you relate to attachment and beginning relationships, how you experience feeling out of control, how you experience something youve never done before. Its incredibly personal.

Dr. Sacks frequently refers to the concept of matrescence, a term coined by medical anthropologist Dana Raphael in the 70s to describe the seismic shift a woman undergoes from womanhood to motherhood. Its body, mind and hormonal, with all these subcategories like sociocultural, financial, interpersonal, she said.

Katie Shea, a 32-year-old venture capitalist in Manhattan, felt this transition acutely when she had her first baby in January and didnt experience an immediate connection. I just felt very disconnected from my old me, and like I was mourning a really fun chapter of my old life, she said. My husband and I were coming from this awesome, newly married independence where we would meet each other for a drink after work to managing a new chapter in our lives that was very tactical and regimented. I felt like I was in the same room with my husband, missing my husband.

It didnt help matters that Shea was being bombarded with texts and calls from well-meaning friends, saying, Isnt this the happiest youve ever been? Theres nothing that compares to this type of love! Shea wasnt there yet: I was like, I guess, she said.

Elle Wang, 33, a partnership adviser at the United Nations in New York who lives in Long Island City, Queens, was surprised by her adjustment period when her son George was born in March, five weeks early.

Not only were she and her husband physically separated from their son in the newborn intensive care unit, which caused her tremendous anxiety, but she felt emotionally unprepared for the suddenness of his arrival.

Everything happened so quickly that I was thrown into this role immediately, said Wang, who was on maternity leave when we spoke. And it took me quite a few days to kind of come to my senses and think, This is my baby. You think its going to be this magical thing, but I think it takes people longer to really connect to the level that movies and TV shows actually project. Its not often immediate, but people dont want to admit that.

Meredith F. Small, Ph.D., a professor of anthropology at Cornell University, said that bonding is not instantaneous, but a process. Most women have a long labor, and theyre exhausted and overwhelmed, she said.

Attachment takes time, Dr. Small said, and there are many parents who do it much more slowly. You know, we believe in love at first sight but thats between two adults, and that doesnt happen very often. Attraction happens instantly, but real, deep, connected, forever love in an instant? Extraordinarily rare, she said with a laugh. And human infants are not necessarily very attractive when theyre first born.

Dr. Small added that deeper parental instincts are still at work. Chances are that the evolutionary push to protect that baby would still be there, she said. Even if you dont feel that close and youre wondering, Why is this baby here? if someone came in and tried to hurt that baby, youd have a different response.

During those first few weeks, on the advice of my pediatrician, I made skin-to-skin contact with my baby as often as possible, and I constantly carried her close to me in a sling. I gave Sylvie massages on the recommendation of a neonatal nurse, which several studies show can strengthen your connection.

Finally, while feeding her one morning, a feeling of warmth so intense it almost knocked me over engulfed me as we gazed into each others eyes.

Shea had a similar experience. A newborn might not seem to recognize us immediately, but when her daughter Lillie started smiling at four weeks, that feedback loop, that reciprocation, was my total light switch moment when I fell in love, she said.

Wang said connection wasnt instantaneous for the whole family. It took me some time. It took my husband some time. It took the baby himself some time! The baby needs a moment, too. And I think if we have an honest conversation about it, it can save some people heartache.

So, ditch the guilt. A heartening new Lehigh University study found that when caregivers respond to their babys need for attention, they need only to get it right half the time to provide a secure base for baby. As study author Susan S. Woodhouse, an infant researcher, put it, You dont have to be perfect, you just have to be good enough.

Theres no lost time, said Dr. Sacks. Those first few moments, or days, are not paramount in your relationship with your child. Your relationship is about a much larger story than a few days.

Jancee Dunn is the author of How Not To Hate Your Husband After Kids.

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Science Talk – Debunking 13 common cancer myths – The Institute of Cancer Research, London – The Institute of Cancer Research

Friday, October 11th, 2019

Cancer myths irritate me. Not only because they fly in the face of scientific research, but also because they prey upon people who are just trying to do their best to live a healthy life.

These myths start to get especially dangerous when they might affect someones response to a cancer diagnosis, so I reached out to some researchers at the ICR to find out which myths bug them the most. Here are the top 13:

There are many types of cancer which you are more likely to develop if someone in your family has had them, but a very small number of cancers are inherited. There is lots of research looking into genes which might identify those at higher risk of developing cancer, and whether this risk affects other people in the family.

But the overwhelming majority of cancers are caused by changes to your DNA that happen over the course of your lifetime, in response to changes in your environment or the ageing process.

Cancer is easy to kill. If you put some cancer cells in a dish and pour some bleach on them, they wont survive for very long. Pouring bleach on some bacteria growing in a petri dish would have much the same effect, but we dont take bleach when we have an infection, for the same reason we dont take it when we have cancer.

The reason finding cancer treatments is so hard is because cancer cells are just normal cells which have turned malignant. Anything that kills a cancer cell is therefore likely to kill your own healthy cells as well. The ideal cancer drug is selectively toxic it will only harm the cancer cells and leave your own cells unscathed.

While older chemotherapy treatments are famously difficult for patients and come with a whole host of nasty side effects, modern research is focused on developing smarter, kinder treatments.

Many of these treatments focus on training your immune system to spot cancer cells and fight them, or therapies which target the genesthat have caused the cancer in the first place.

While some older cancer treatments may not be as kind as more modern therapies, they dont make cancer worse.

Cancer is very much a real disease. Theres not a whole lot else to say on this one. Watch this video of a patient affected by the ICR's research:

The theory behind this myth is that excessive exposure to radiofrequency energy from cellular phones causes cancer. The basic cause of cancer is damage to your DNA, a discovery that was made at the ICR.

But there is no evidence that radiofrequency waves cause DNA damage, which is what leads to cells becoming cancerous, so the pylons/mobile phone myth simply doesnt add up. Radiofrequency waves are nowhere near as strong as other types of radiation like x-rays or UV, which can break the chemical bonds in DNA.

If youve ever heard someone suggest that childhood leukaemia is caused by radiowaves or pollution, Professor Mel Greaveshas published research which shows that there is a clear, biological cause of the disease.

You can read more from Professor Greavesin this blog post which tackles more myths about the causes of leukaemia.

Not dissimilar to the mobile phones myth above, this one stems from a belief that the radiofrequency waves in microwaves can somehow increase the incidence of cancer.

But just like mobile phones, the radiofrequency waves are much too low in energy to cause the damage to DNA which leads to cancer.

Vaccines prevent disease by exposing the immune system to small, often inactive, amounts of infectious material that help it recognise the real disease when it comes along.

There is no link between vaccines and an increased risk of cancer. Cancer patients cant receive vaccines when undergoing treatment, since their immune systems are usually weakened by these therapies and vaccines require someone to have a functioning immune system in order to work properly.

There are actually two vaccines which can protect against cancer the HPV and HBV vaccines. The HPV vaccines prevents against the Human Papilloma Virus, which is linked to cervical, anal, throat and other cancers. The HBV vaccines protects against the hepatitis B virus, which can cause longterm damage to the liver and increase the risk of liver cancer.

Some people think that its possible for an injury to cause cancer you may have heard anecdotes about someone being involved in a car accident who later goes on to be diagnosed with cancer.

Injuries often require thorough medical examinations including imaging like x-rays and MRIs, and these scans can reveal cancers which were already present before the accident happened.

So while it might seem like the two are related, they usually arent. Some types of cancer, like myeloma, can also cause weaknesses in bones, making them more likely to break, or increase your likelihood of severe bruising, which may lead you to see your doctor who then go on to spot the cancer.

This myth is incredibly pervasive, to the point that some people have 'alkylisers' installed on their kitchen sinks in the hope that drinking alkaline water will reduce their risk of developing cancer.

The story goes that cancer can only grow in an acidic environment, so by eating alkaline foods, you can change your bodys pH and thereby eliminate your risk of cancer.

Except that you cant.

The tumour microenvironment which is the area of cells and tissues that directly surrounds a tumour tends to be acidic. Each organ and tissue in your body has its own optimum pH range in which it functions best, and your body has incredibly tightly regulated systems to make sure the pH never goes outside of this range.

You cannot change the pH of your body by eating alkaline foods. The first place anything you consume goes is your stomach, which is a nice big bath of pH 2 hydrochloric acid.

Yes they do. Sharks get cancer at a rate much lower than humans, but they do still get the disease.

This myth is one of those pervasive ones that is repeated by all kinds of people and the general idea seems to be that if sharks dont get cancer, there might be something about them which holds the key to curing or preventing the disease in humans.

There is some evidence that cartilage is antiangiogenic this means that it prevents the development of blood vessels. Cancer needs blood vessels to be able to grow and thrive, so the theory goes that if sharks are made of mostly cartilage, they wont have the kinds of bodies that can support the growth of tumours.

Its an oversimplification, and sharks do get cancer.

We can learn lots about cancer by studying which animals get it and how it develops you can read more about that in this blog post.

No, you dont need to clean your glasses, you did read that correctly. You may not have heard about vitamin B17 and thats becauseit doesnt exist.

Vitamin B17, also called laetrile, is touted as an alternative therapy for cancer, but there is no evidence that it works. Its a manmade version of a chemical found in lots of different plants, and it contains cyanide.

There is no reliable evidence that it works as a cancer treatment or as a treatment for anything else. Its not available for sale in the UK or Europe, due to lack of evidence of its effectiveness.

If there is, wed love to hear about it! The big issue with this myth is of course the notion that cancer is one disease, and it can be cured by any one drug or treatment. The reality is that cancer is an incredibly complex and varied disease. It always has its basis in genetics, but there is a world of a difference between rhabdomyoscaroma and neuroblastoma.

Categorising cancers into groups which have common characteristics helps researchers know where to focus, and helps clinicians know which treatments are likely to be most effective.

So there is no one cure for cancer, because cancer is not one disease.

While eating a healthy, balanced diet with plenty of fruit and vegetables is important to maintain good overall healthand has been linked with reduced cancer risk, no particular food item can be singled out as having a significant impact in either preventing or treating cancer.

News headlines occasionally report that 'X food fights cancer' but these are usually extrapolations of the real research.

While I do love the idea of scientists shooting blueberries out of a cannon at cancer cells growing in a dish, the reality is usually that one single chemical compound from one type of plant is methodically tested to assess its ability to selectively kill cancer cells, and the research is then published in the academic literature.

Not as jazzy, but still very important work!

Sadly, there is still a long way to go when it comes to improving cancer treatments, and its a myth that we wont still lose people to the disease. Scientists and clinicians are making leaps and bounds when it comes to researching cancer, its causes and potential solutions to fight it.

The ICRs new Centre for Cancer Drug Discoverywill focus on trying to outsmart cancer as the disease evolves to adapt to the latest treatments, and the pace of developments in artificial intelligence means were always taking steps forward in beating the disease.

Ill be taking about 30,000 steps forward on 13 October in the Royal Parks Half Marathonto raise funds for the ICR and Ill be keeping the devastating truths of cancer in my mind every step of the way.

To support Joanne and donate to the ICR, please visit her fundraising page:

Support Joanne

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BNA Interview Series: Exploring the Inflamed Mind With Professor Ed Bullmore – Technology Networks

Friday, October 11th, 2019

At the British Neuroscience Association (BNA)s Festival of Neuroscience in April 2019, we were lucky enough to sit down with some influential neuroscientists to discuss their work. Weve assembled these transcripts into our BNA Interview Series. Here, in our final interview of the series, we talk to Professor Ed Bullmore, who splits his time between academic research at the University of Cambridge and industry research with GSK. Professor Bullmore was at the conference outlining some of the evidence that connects inflammation and depression, and the possibility that the immune system could be targeted as part of future antidepressant treatments.Ruairi Mackenzie (RM): Could you outline the link between inflammation and depression?

Ed Bullmore (EB):Well I think the first thing to say is that inflammation and depression go together, so they co-occur; theyre correlated with each other. That, I would say, is beyond reasonable doubt. You can look at two kinds of evidence for that association. You can look at people who have an inflamed body, who have a major medical inflammatory disorder like arthritis or psoriasis or inflammatory bowel disease and ask the question, is that associated with an increased risk of depression? And it is, very robustly. You can also go to people who have depression but dont have an obvious medical inflammatory disease, you can take a blood test and you can measure the inflammatory state of the immune system in a more sensitive way and you can show a very consistent trend and people have shown this over multiple years and multiple studies that on average, people with depression have slightly but significantly increased levels of inflammatory proteins in circulation compared to healthy controls. So, those two bits of evidence I think put it beyond reasonable doubt that there is an association. The question then is about causation. What drives that association and what is the evidence that inflammation and depression are not just kind of going together but one is driving the other, particularly inflammation driving depression.RM: Whatisthe evidence that inflammation is the driving factor behind depression?

EB:There is a lot of evidence from animal studies. If you make an animal inflamed, you will change its behavior so that it looks as if it might be depressed. You can change their social behavior, their interaction with other animals, they are less likely to drink sweetened water, more likely to drink plain water as if they have lost the capacity for pleasure. There are various other sleep and behavioral changes that you can see in animals that look depressed but perhaps the most convincing evidence comes from studies in humans and one thing that you would predict, if inflammation caused depression, then you might expect to find examples of inflammation preceding or anticipating depression because cause precedes effect. If you look, there is evidence for that too.So if you look at long term follow up studies, epidemiological studies, it has been shown that if you are inflamed but not depressed at one point in time then over follow up you are more likely to be depressed than the people that were not inflamed originally. So theres that kind of evidence. You can see in patients, for example, that have got hepatitis, a viral infection of the liver, if you give them an inflammatory treatment to cure their hepatitis, about a third of them will become depressed.RM: Really? Thats really fascinating, that last piece of evidence. Do you see that over time that if their inflammation goes away for whatever reason, they are less likely to become depressed?

EB:Im not sure that thats been so certainly studied, but what I think is pretty clear is that inflammation can precede depression and that, I would say, is a necessary condition for inflammation to be causal.RM: Depression is an immensely complex condition so different risk factors will have different contributions. Are there any firm numbers on what is the significance of this contribution to depression versus other factors?

EB:Well I think its very important, as your questions is suggesting, were not talking about inflammation explaining every case or experience of depression, but based on blood test measurements, it looks like about a third of people with major depressive disorder might also be inflamed and then you think about all the people with so-called comorbid depression, people with arthritis, inflammatory bowel disease. In rheumatoid arthritis, for example, about 25% of those patients are significantly depressed. So, its quite a big chunk of people. Its not everybody, but its a lot of people, I think.RM: Rheumatoid arthritis and some other conditions which involve chronic inflammation, they dont just impact our bodies but also our social lives. It might make it harder for people to leave the house and socialize with friends and obviously social isolation is also a risk factor of depression. Are there studies or have there been observations made that isolate the two?

EB:No, is the short answer. I mean, I think particularly depression, fatigue and other psychological symptoms have been woefully under investigated, in my opinion, in arthritis and other medical conditions. We need to do much more. The traditional explanation is more what you might call a sociological explanation. Youre depressed because youre thinking about arthritis, because of the impact that it has on your life. It might make it more difficult for you to interact with friends, you may feel gloomy about what the future holds. Are you going to end up in a wheelchair? How is it going to impact on your mobility in the long term? Thats the traditional explanation, and I wouldnt claim that those psychological mechanisms are not at all relevant to the link between depression, arthritis or other inflammatory diseases but I think its important that we allow the possibility that there could be other explanations. There could be a more direct mechanistic link between the autoimmune disease, the inflammatory disease and the body in these patients and their altered mental state.RM: Have there been studies into immunocompromised populations; are they less likely to become depressed?

EB:Its an interesting idea. No, Im not aware that there have been studies looking at immunodeficiencies. I would say there is an opportunity for a lot more work to be done at the interface between mind and body, particularly in what you might traditionally regard as non-psychiatric disorders, and that could include immunodeficiency syndromes as well as autoimmune disorders like arthritis.RM: Are these inflammatory effects isolated to just depression or are there other conditions that are associated?

EB:I think the existing evidence is strongest for depression but if you delve into the literature there is quite a strong story about psychosis in some cases, psychosis being associated with a different kind of abnormality of the immune system. There is a small percentage of patients with a first episode of psychosis who have high levels of autoantibodies. Antibodies that are directed against the bodys own proteins, particularly the glutamate receptor. The anti-NMDA antibody is associated with psychosis and thats an interesting story that people are exploring. I think the other area where there is a lot of interest is neurodegeneration, Alzheimers disease, for example. People are increasingly interested in the idea that when the plaques and tangles of amyloid and tau protein form in the brain, maybe the immune system sees those abnormal proteins as if they were germs, as if they were antigens, and that stimulates an immune response, an inflammatory reaction in the brain which could be damaging to nerve cells and could contribute to neuronal loss and psychological deterioration. So, a lot of companies are interested, I think, in developing new anti-inflammatory treatments to arrest the rate of progression in neurodegenerative disorders.RM: Do these studies look at immune populations specifically within the brain or in the rest of the body as well?

EB:Well its much, much easier to look at the immune system in the rest of the body than the brain. You can get a pretty good read on the immune system from a blood sample but that doesnt tell you anything about the microglial (immune cells resident within the brain) status, for example. I think its one of the key challenges for the field is to develop better biomarkers of brain inflammation. We have very limited options now. You can take a cerebrospinal fluid (CSF) sample and you can measure inflammatory proteins and a few immune cells in a CSF sample but a lot of patients with depression arent going to go along with that. What else have we got? Well you can use various imaging techniques, structural MRI, functional MRI. There are changes in those markers associated with altered levels of peripheral inflammation but the signal itself is not very specific to the immune system. The most promising approach I think, is going to be developments using positron emotional tomography (PET) where you can get a tracer into the blood that will bind to a specific target in the brain and there has been quite a lot of work looking at PET markers that allegedly are specific to microglial activation which have shown increases in Alzheimers disease and also in depression. If you talk to people in the field, I think everybody agrees that the existing PET traces of brain inflammation are better than nothing, but theyre not as specific or sensitive as we want them to be. So I think thats an area where I will hope to see progress over the next few years, is development of better neuroimaging tools for central inflammation.RM: Thinking about the next few years, as a final question, what do you think the future of depression treatment looks like?

EB:Well, what I really hope is that we get away from this idea that depression is just one thing, that everybody is depressed for the same reason and that one day there will be a panacea. That there will be a drug or a psychological intervention thats going to make everybody happy, cure depression for everybody. I think thats been the mindset for a lot of drug development in the past and I think we need to move on from that. Psychiatry, I hope, will catch up with the rest of medicine. The rest of medicine doesnt treat symptoms as if they are all the same, the rest of medicine looks for the causes of symptoms and it tries to treat those causes. So my hope for the future of depression is that we will get to a place where we are beginning to identify causes, we are beginning to get cleverer about identifying which patients are depressed for which particular reason and more precisely targeting treatments to the individuals most likely to respond because their depression is caused by some factor that is responsive to the treatment in question. That kind of more personalized, precise approach is, I hope, where we will get to.RM: Will this strategy involve just pharmacological interventions or also other therapies?

EB: Absolutely, I think thats a very important point. You know, as you have mentioned I work also at GSK and come at this really from the point of view of wondering whether, by focusing on the immune system, could we find the next generation of antidepressant drugs, but the science of neuroimmunology, the interaction between the brain and the immune system, I dont think means that the treatments have to be pharmacological. I think there is a lot of interest in vagal nerve stimulation as a treatment for depression. We know that vagal nerve stimulation often has anti-inflammatory effects. There is a little bit of work in the literature there could be more showing that, for example, meditation has anti-inflammatory effects and so there are a lot of ways in which the immune system could be dampened down or controlled. Diet is another obvious example a lot of inflammation might have its origin in the microbiome could you be effective with a dietary regime change that might alter the microbiome, make it less provocative to the immune system? I think these are all hopes for the future.

Professor Ed Bullmore was speaking to Ruairi J Mackenzie, Science Writer for Technology Networks. Interviews have been edited for length and clarity.

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More benefits to vaccination: rotavirus vaccines reduce the incidence of type-1 diabetes | Speaking of Medicine – PLoS Blogs

Friday, October 11th, 2019

Kaitlin A. Davis and Andrew Mehle discuss the research and context behind the new PLOS Pathogens Pearls article, Does rotavirus turn on type 1 diabetes?.

There is a growing appreciation that viral infections can have long lasting impacts, well after the original infection has been cleared. One example is the proposed connection between childhood infections with rotavirus and the subsequent development of type 1 diabetes. As highlighted in a PLOS Pathogens Pearls article this month, new evidence supports this correlation and suggests that vaccination against rotavirus may contribute to a global decrease in type 1 diabetes prevalence among young children. This surprising effect of vaccination could be the first example of primary prevention of type 1 diabetes, something not currently possible.

Rotavirus, a member of the Reoviridae family, is a major cause of infantile diarrheal disease worldwide, accounting for over 215,000 deaths annually. In a powerful demonstration of the positive effects of public health campaigns, mortality associated with rotavirus infection has substantially decreased since the introduction of rotavirus vaccines. Now, multiple studies have described an associated decrease in type 1 diabetes incidence following vaccination.

How might rotavirus infection be tied to the development of type 1 diabetes? Type 1 diabetesis an autoimmune condition characterized by the destruction of beta cells in the pancreas by the bodys own immune system, leading to the functional absence of insulin While there are some genetic determinants of type 1 diabetes, the precise triggers of this autoimmune disease are not fully understood. Interestingly, portions of proteins on the surface of beta cells that are recognized by T cells the killers of the immune system are strikingly similar to a rotavirus capsid protein called VP7. Both the beta cell protein and its viral doppelganger VP7 are able to stimulate similar T cell responses, and this response can be observed in both humans and animals following infection and vaccination. Previous studies have directly linked rotavirus infection to the production of antibodies associated with diabetes in young children, and similarly, infections in mice have been linked to pancreatic cell death and hyperglycemia. Perhaps rotavirus infection trains the immune system to accidentally target beta cells.

Rotarix [GSK] and RotaTeq [Merck] are the most routinely used rotavirus vaccines, administered in the first six months of life. These vaccines include HLA-mimic VP7 sequences and were fully introduced to communities worldwide from 2006-2008. In studies from both Australia and the United States spanning this time period, type 1 diabetes prevalence decreased coincident with vaccine introduction. In Australia, reported by Perrett, et al., the number of new cases of type 1 diabetes among children 0-4 years of age decreased by 15% following the introduction of rotavirus vaccines. Excitingly, this finding was recapitulated in an American cohort, where a 33-37% reduction in the risk of type 1 diabetes was observed following completion of a rotavirus vaccine series. Thus, if rotavirus infection is a trigger for the development of type 1 diabetes, preventing infections by vaccination would not only reduce viral disease, but have the added benefit of reducing type 1 diabetes. This is exactly what is reported in these new studies and summarized in the PLOS Pathogens Pearls article.

While trends are common between these two diverse studies, there are likely additional factors that contribute to protection. An analysis of a Finnish cohort reports that associations between rotavirus vaccination and type 1 diabetes incidence were inconclusive. This may in part be due to sample size variability between the studies, but also highlights the role of geographical and environmental differences in immunity. Rotavirus mortality and vaccine efficacy are known to vary significantly by country and environment, and similarly, factors promoting type 1 diabetes incidence are likely to be diverse. If the associations outlined in these studies hold true for multiple groups and persist as children age, these findings could outline at least one ubiquitous factor that affects type 1 diabetes development worldwide.

About the Authors

Kaitlin A. Davis received her PhD in Biology from Johns Hopkins University, under the mentorship of Dr. John T. Patton, where she studied mechanisms of rotavirus immune evasion and antagonism. She is currently a postdoctoral research associate with Andrew Mehle at the University of Wisconsin Madison studying how ADP-ribosylation of influenza virus proteins regulates viral replication processes. She also serves on the American Society for Virology executive council.

Andrew Mehle received his PhD in Virology at Harvard University training with Dr. Dana Gabuzda to study virus:host interactions during HIV infection. He continued with postdoctoral training at the University of California Berkeley in the lab of Dr. Jennifer Doudna where his focus shifted to influenza virus. He established his own lab at the University of Wisconsin Madison in 2011 (mehlelab.com), where he is currently an Associate Professor in the Department of Medical Microbiology and Immunology and holds an Investigators in the Pathogenesis of Infectious Disease Award from the Burroughs Wellcome Fund.

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Canine pals could be the secret to longevity – Cosmos

Friday, October 11th, 2019

As most dog owners will attest, four-legged canine companions generate boundless love and joy through their playful antics and tail-wagging devotion.

Accordingly, much research finds they can improve mental health - and now, evidence for their tangible physical health benefits is growing.

A Swedish study and separate meta-analysis, published in the journal Circulation, found that dog owners live longer and do better after having a heart attack or stroke.

First, the Swedes compared the health outcomes of 182,000 people with and without dogs after a heart attack and 155,000 people after a stroke, using health data recorded by the Swedish National Patient Register between 2001 and 2012.

The largest differences between dog owners and non-owners were seen in single households.

After adjusting for demographic and socioeconomic factors, they found that dog owners who lived alone had 33% lower risk of death after a heart attack and 27% less chance of death after a stroke. The effect was not quite as pronounced for people living with a partner or child, with 15% and 12% lower risk, respectively.

Although the mechanisms cant be confirmed with the observational study design, senior author Tove Fall from Uppsala University in Sweden says he was surprised at the large differences in the outcomes, and thinks its likely that exercise and companionship factor in.

We know that dogs can be a good motivator for physical activity, he says. We also know that physical activity and social support are important for optimal recovery after a major cardiovascular event.

Meanwhile, clinician and research scientist Caroline Kramer, from Mt Sinai Hospital in Toronto, Canada, was curious about research showing the benefits of dog ownership in her pursuit of lifestyle changes that can promote peoples health.

What really sparked it, she admits, was her dog a miniature Schnauzer called Romeo.

Since I adopted him, she says, I got more active, and the daily routine with a dog companion is a joy. So when I saw a research report on that I was curious and decided to research further.

The result was a systematic review and meta-analysis of the association between dog ownership and death from all causes or heart disease.

The composite analysis included 10 studies with data from 3.8 million patients and follow-ups ranging from one to 22 years. Overall, having a dog prolonged survival, reducing risk of death by 24%.

When it came to heart attacks and other heart-related issues, dog owners had a 65% and 31% lower risk of death, respectively.

The research builds upon prior findings and conclusions of the American Heart Association (AHA)s scientific statement that dog ownership is associated with lower risk factors for heart disease, such as high blood pressure and blood lipid levels, says Glenn Levine, chair of the statements writing group.

Further, these two studies provide good, quality data indicating dog ownership is associated with reduced cardiac and all-cause mortality, he adds.

While these non-randomised controlled studies cannot prove that adopting or owning a dog directly leads to reduced mortality, those robust findings are certainly at least suggestive of this.

In a related editorial, Who is rescuing whom?, Dhruv Kazi, from Harvard Medical School, Boston, notes that pet owners tend to have other heart-health promoting features. These include being younger, better educated, wealthier and more likely to be married. Its also possible that healthier people are more able to adopt a dog.

However, he remarks that its plausible they improve peoples health, given that dog ownership prompts more time being active outdoors. He also notes evidence that the rich variety of germs they bring into the home can positively alter peoples gut microbiome.

He agrees with the AHA, though, that medical reasons alone should not the driving motivator to get a dog, as its a much larger undertaking than embarking on a new medical therapy, involving significant commitment and lifestyle changes.

Quoting Pulitzer-Prize winning poet Mary Oliver, he concludes that the real reward of dog ownership is that there can hardly be a sweeter arrangement than the unconditional love of a loyal friend.

The health benefits of dog ownership are a welcome and possibly substantial bonus.

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Decoding the Genetic Mechanisms of Aging – Technology Networks

Friday, October 11th, 2019

The discovery in the 1990s that a mutation in a single gene of an experimental worm could double its lifespan set off a stampede of research on the molecular biology of aging and triggered hopes that drug therapies or other interventions could be developed to extend healthy human lifespan. But as is often the case in science, the genetic regulation of aging is more complicated than it first appeared.

The nature of this complexity is illuminated in a new paper byMDI Biological LaboratoryscientistsJarod Rollins, Ph.D., andAric Rogers, Ph.D., co-corresponding authors, which describes the mechanisms by which longevity is regulated post-transcriptionally, or after a genetic blueprint has been transcribed from an organism's DNA. The identification of these mechanisms will serve as a road map for screening new, more specific drugs to prolong healthy lifespan.

The research was conducted inC. elegans, a tiny nematode worm that is a popular model in aging research because of its genetic similarity to humans and because of its short lifespan, which allows scientists to easily study lifespan-extending interventions.

"The MDI Biological Laboratory is deeply committed to translational research, or research that can be translated into therapies to improve human health in our focus areas of regeneration and aging," saidHermann Haller, M.D., president. "Because it identifies new potential drug targets in the form of the post-transcriptional mechanisms governing longevity, this research will be hugely important in screening for new therapies to extend healthy human lifespan."

The paper, "Dietary Restriction Induces Post-transcriptional Regulation of Longevity Genes," which was recently published in the journalLife Science Alliance, is the product of five years of research in the Rollins and Rogers laboratories at the MDI Biological Laboratory.

The scientists used bioinformatics, or data analysis, techniques to compare genes in worms fed normal diets with those whose diets were restricted.Dietary restriction, or DR, which refers to calorie restriction without malnutrition, is the most robust intervention known for extending lifespan, and has been demonstrated to increase lifespan and delay the onset of age-related degenerative disease in a wide range of species, from one-celled yeasts to primates.

The scientific evidence on the lifespan-prolonging effects of DR has ignited a quest to develop "DR mimetics," or drugs that mimic the effects of DR without the need to dramatically reduce calories. In addition to being difficult to adhere to, such a diet is associated with negative side effects including increased sensitivity to cold and loss of energy and libido. The identification of these new mechanisms opens up the possibility of developing new, more precise DR mimetics.

"Science already knows a lot about how longevity is regulated at the genetic level, but the picture isn't complete if we just look at transcription," Rollins said. "With this research, we are drilling down to additional layers of regulation, which brings us one step closer to extending healthy human lifespan without the need to dramatically restrict calories or to take drugs that, because they are less selectively targeted, are more likely to cause adverse reactions."

The goal of DR mimetics is to access the adaptive programs in the cell that are activated when an organism is exposed to an existential threat such as a scarcity of nutrients. In such a case, the cellular machinery shifts from an emphasis on growth and reproduction, which is costly in terms of cellular resources, to an emphasis on survival. In order to ensure that an organism survives to reproduce when conditions improve, nature seeks to ensure that its cells function at peak efficiency.

In addition to confirming existing theories about the adaptive response to DR, the paper highlights the importance of post-transcriptional regulation -- or regulation that occurs after a gene has been "read" or "transcribed" from the DNA in the nucleus of the cell. The identification of the mechanisms that govern post-transcriptional levels of gene expression charts a pathway for screening, or testing, drugs that may have pro-longevity effects.

"We found that hundreds of genes are being regulated almost solely at the post-transcriptional level," Rollins said. "These are genes that weren't previously known to have a role in longevity. This level of regulation can be missed if scientists are looking at the transcriptional level alone. The identification of these mechanisms gives us a better idea of how DR works and opens up a whole new area of potential investigation for the aging biology community."

Reference: Rollins et al. 2019.Dietary restriction induces posttranscriptional regulation of longevity genes. Life Science Alliance. DOI: 10.26508/lsa.201800281.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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The longevity of ‘Little Women’ – WCVB Boston

Friday, October 11th, 2019

The longevity of 'Little Women'

Visit the house where Louisa May Alcott wrote 'Little Women' 150 years ago

Updated: 8:10 PM EDT Oct 4, 2019

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ANTHONY: A GRAND CELEBRATION CALLS FOR A FRESH COAT OF PAINT AT THIS ORCHARD HOUSE IN CONCORD. 2018 MARKED THE SESQUICENTENNIAL OF THE PUBLISHING -- PUBLICATION OF LITTLE WOMEN. >> I AM REREADING IT WITH MY BEST FRIEND. IT WAS NEAT BEING ABLE TO COME AND SEE THE HOUSE. ANTHONY: WRITTEN HERE 150 YEARS AGO, NEVER OUT-OF-PRINT, TRANSLATED INTO 50 LANGUAGES. HOLLYWOOD HAS MADE ANOTHER MOVIE OF THE CLASSIC. THIS ONE DIRECTED BY OSCAR NOMINATED GRETA GERWIG. >> GRETA GERWIG AND THE ACTRESSES HAVE COME THROUGH MULTIPLE TIMES ASKING QUESTIONS, WANTING TO ABSORB THE HOUSE. THEY WANTED THE EXACT RANGE COLOR. THEY HAVE BEEN PASSIONATE ABOUT GETTING IT RIGHT. ANTHONY: THERE IS NO SHORTAGE OF PASSION FOR ORCHARD HOUSE, SAYS EXECUTIVE DIRECTOR JAN TURNQUIST . VISITORS FROM AROUND THE WORLD FIND THEIR WAY HERE. >> IT SEEMS TO SPEAK TO THE HEART OF SO MANY READERS, THE MATTER WHAT THEIR CULTURE. THE FACT YOU CAN COME INTO THE ROOMS AND FEEL AS IF THE FAMILY HAS JUST LEFT A MOMENT AGO, IT IS AS CLOSE AS THEY CAN COME TO MEETING THE AUTHOR. ANTHONY: MOST NOTABLE IS LOUISAS WRITING DESK. >> BRONSON AND ABIGAIL GOT -- THEY FELT THEIR DAUGHTERS SHOULD FILL THEIR OWN DESTINY. A DESK OF HER OWN IN ANOTHER EMILY WOULD HAVE BEEN CONSIDERED FOR BITTEN. PHYSICIANS HAD PROVED SUPPOSEDLY BRAINWORK LIKE WRITING WOULD DESTROY A WOMANS HEALTH. THEY THOUGHT IT WAS RIDICULOUS. BRONSON BUILT LOUISA THE DESK AND MRS. ELLICOTT GAVE HER A PEN. THE MAVIS PENN USED TO INSPIRE WHEN WRAPPED IN -- [INDISCERNIBLE] ANTHONY: THE EDUCATOR FOUNDED THE CONCORD SCHOOL OF PHILOSOPHY AND LITERATURE IN HIS STUDY. HE BUILT A LECTURE HALL OUTSIDE. THE SCHOOL IS SLATED FOR ITS HOLLYWOOD DEBUT. >> THE MAKERS OF THIS MOVIE WANTED SO MUCH TO DO SOME OF THE FILMING HERE AT THE SCHOOL. THEY THOUGHT IT WOULD WORK FOR THE SCENE WHEN AMY MARCH BRINGS PICKLE BLINDS TO SCHOOL. ANTHONY: 150 YEARS AND STILL GOING STRONG. WHAT WOULD LOUISA MAKE OF ALL THE FUSS. >> SHE WOULD COMPLETELY ASTONISHED IT COULD CONTINUE LONG AFTER THE PUBLICATION OF HER BOOK. 150 YEARS. SHE WOULD BE AMUSED, PLEASED AND MOSTLY AMAZED. ANTHONY: ALL OF THE ABOVE. LITTLE WOMEN CHRISTMAS DAY. SHAYNA: THAT IS CHRONICLE FOR TODAY. THANK YOU FOR JOINING US. I AM SHAYNA SEYMOUR. ANTH

The longevity of 'Little Women'

Visit the house where Louisa May Alcott wrote 'Little Women' 150 years ago

Updated: 8:10 PM EDT Oct 4, 2019

2018 marked the sesquicentennial of the publication of "Little Women." Written in Concord at Orchard House 150 years ago, it never went out of print and has been translated into 50 languages. It is so tried and true, Hollywood has made yet another movie of the classic, this one directed by Oscar-nominated Greta Gerwig.

2018 marked the sesquicentennial of the publication of "Little Women." Written in Concord at Orchard House 150 years ago, it never went out of print and has been translated into 50 languages. It is so tried and true, Hollywood has made yet another movie of the classic, this one directed by Oscar-nominated Greta Gerwig.

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The longevity of 'Little Women' - WCVB Boston

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Lordi Envision Greater Longevity With ‘Killection’ Album – Loudwire

Friday, October 11th, 2019

The records state that Lordi formed in 1992 and released their first album in 2002, but what if they actually had been around much longer? That's a bit of the idea behind their latest album, Killection.

According to the press announcement for the new album, the group has envisioned the release as if they had actually been around making music since the early '70s, with this selection of songs spanning that entire era.

"Killection is a compilation album that simply says what if Lordi had been in existence since the early 70's. It contains all their imaginary hit singles from different periods done with painstaking attention to detail using authentic studios and vintage technology. This is how they would have sounded if Lordi would have made music back then and therefore would have had the hit material to release this compilation now," reads a description for the album.

Mr. Lordi himself adds, "Killection is a fictional compilation album. It contains songs that Lordi would have written between the early 70's through the mid-90's. The compilation contains one "brand new" song from 2019 as well, cause thats somehow always typical for compilations."

Killection is due Jan. 31 and you can check out the artwork and track listing below. At present, they have a one-off in Helsinki, Finland on Dec. 13, but will return to the road in earnest in February for a month-and-a-half long European tour. See all their dates here.

Lordi, Killection Artwork + Track Listing

01 Radio SCG 1002 Horror for Hire03 Shake the Baby Silent04 Like a Bee to the Honey05 Apollyon06 SCG10 the Last Hour07 Blow My Fuse08 I Dug a Hole in the Yard For You09 Zombimbo10 Up To No Good11 SCG10 Demonic Semitones12 Cutterfly13 Evil14 Scream Demon15 SCG10 I Am Here

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Lordi Envision Greater Longevity With 'Killection' Album - Loudwire

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