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Archive for the ‘Longevity Genetics’ Category

Lifeist Subsidiary Mikra Cellular Sciences to Launch First Product CELLF to Combat Brain Fog and Unlock Healthy Aging, Announces U.S. Patent…

Wednesday, December 8th, 2021

- Mikra patent focusing on novel cellular therapeutic targeting systemic fatigue- Mikra partners with InVivo Biosystems for pre-clinical trials to strengthen patent application and generate further data confirming expression pathways for genes

TORONTO, Dec. 06, 2021 (GLOBE NEWSWIRE) -- Lifeist Wellness Inc. (Lifeist or the Company) (TSXV: LFST) (FRANKFURT: M5B) (OTCMKTS: NXTTF), a health-tech company that leverages advancements in science and technology to enable you to find your path to wellness, today announced that its newly launched biosciences and consumer wellness subsidiary, Mikra Cellular Sciences Inc. (Mikra), is poised to launch its first product CELLF, a novel cellular therapeutic compound targeting systemic fatigue. As part of pre-launch activities of CELLF, Mikra has filed a patent application with the United States Patent and Trademark Office and partnered with InVivo Biosystems, Inc. (InVivo Biosystems) for pre-clinical trials to strengthen its patent claim.

The real health crisis isnt reduced longevity were living longer than we have in the past. Its extended morbidity thats the problem. While were all familiar with mortality, morbidity is attributable to age-related diseases that lower your quality of life which is why so many of us when we hit our 30s, 40s and 50s experience multiple physiological and mental walls notably brain fog, fatigue, and inflammation. This all happens at a cellular level, and it can cascade into poor sleep, mood drops, and an inability to enjoy life like you want to, said Faraaz Jamal, COO of Lifeist and CEO of Mikra. With that in mind, Im extremely excited to present Mikras first product, CELLF (pronounced self). We engineered this product for everyone who has started to feel like their biological age is affecting their everyday performance and ability to feel like the best version of themselves.

Continued Jamal, CELLF works at a cellular level to help combat systemic fatigue, inflammation, and brain fog by promoting the creation of mitochondria and subsequently increasing their efficiency. This is in addition to the upregulation and downregulation of certain cellular detoxification pathways that can remove the buildup of senescent (old/dysfunctional) cells that may cause excessive chronic inflammation and uncontrolled cell division.

CELLF - A science-backed cellular therapeutic, treating systemic fatigue and low-grade cellular inflammation

CELLF is manufactured in a proprietary oxygen-deprived environment to maintain biopotency and bioavailability with clinically tested United States Food & Drug Administration (FDA) certified GRAS (generally recognized as safe) bioactive ingredients. The CELLF compound delivery system is a two-stage, patented mechanism it is first bound to a transferrin glycoprotein and then encapsulated within a liposome. This allows safe passage of CELLF through the gastric environment and delivery directly into the blood plasma. The result is optimal delivery of our compound with minimal degradation to the best site of absorption. CELLF will be shipped in a package containing 30 X 10ml single-serve sachets to prevent oxidation and maximize bioavailability.

Youve got to satisfy two conditions for a product like this to work. The first is that the molecules within the compound need to be backed by rigorous science. The second is that you need to deliver it effectively into your body, and more specifically, your cells so that it is maximally absorbed. Very few products satisfy the first, let alone the second, said Jamal. As one of my lifelong heroes, Carl Sagan once said, extraordinary claims require extraordinary evidence, which is why weve partnered with Invivo Biosystems to prove and strengthen our patent claim that CELLF does both.

Mikra Partners with InVivo Biosystems

Mikra has partnered with InVivo Biosystems, experts in genetic model creation and in vivo testing, to strengthen its patent application by conducting a pre-clinical study identifying genetic signatures and pathways associated with average human healthspans and to test the effects of CELLF on healthy aging.

We are proud to partner with Mikra in developing a family of healthy living products that reduce biological aging. At InVivo Biosystems, we take a systematic, multi-omics approach to make gene-by-gene discoveries and uncover the different genetic pathways that are up or down regulated during aging. The InVivo Longevity Platform measures the complex interplay of cellular proliferation, autophagy, mitochondrial oxidative stress, genetic predisposition, and transcriptional changes that occur during aging, said Chris Hopkins, PhD, Chief Science Officer at InVivo Biosystems. In our collaboration with Mikra, we are exploring how its flagship formulation, CELLF, increases the efficiency of mitochondrial ATP production and cellular respiration. Using the InVivo Longevity Platform, we measure at the molecular level how Mikras CELLF formulation can counter periodic bouts of fatigue by providing improved cellular respiration. In our partnership, we will be generating the science-based evidence that Mikra can use as further backbone for their intellectual property claims. Here at InVivo Biosystems we are also excited to continue partnering with Mikra in the future to uncover further how CELLF, and their future product lines, can create a new baseline for healthy living after 30.

CELLF Product & Community Launch

Im very excited about adding incremental value to Lifeist shareholders and unlocking the earnings potential of Mikra and subsequently Lifeist. Were taking the first steps here with bringing something novel to the market, validating and protecting it. But lets be clear, its only the first step, said Meni Morim, CEO of Lifeist. The initial traction Mikra has had around the pre-launch has been very promising to grow to a community of nearly 20,000 with a huge level of engagement, in such a short amount of time and with no sign of stopping is a testament to the teams expertise and validates the consumers desire for this type of product.

Mikras CELLF will be available for pre-sale in mid-Q1 2022 with a waitlist sign up available at http://www.wearemikra.com. CELLF will be available on http://www.wearemikra.com and Amazon following the pre-sale for full public launch.

Follow Mikras journey on your favorite social media platform with @wearemikra.

About Mikra, Cellular Sciences Inc.Mikra is a biological sciences and consumer wellness company on a mission to increase your healthspan by focusing on the tiniest aspect of your health: the cell. People are made up of over 37 trillion cells with a variety of different sizes, shapes, functions and lifespan. These cells are responsible for energy, happiness, recovery potential and so much more. Mikra is exploring the link between changes at a cellular level and the cascading effects it can have on health.

About InVivo Biosystems, Inc.InVivo Biosystems, an expert in genetics, delivers scientific proof and evidence for ingredients at the molecular and cellular level via a proprietary analytical approach. Its analytical platform helps branded ingredient developers and manufacturers substantiate their product claims, file IP patents, or refine their formulations using the best science backed measure of outcome. Managed by experienced PhD scientists, InVivo Biosystems gene expression platform can help find new applications for novel ingredients, discover new molecules, and conduct proof-of-concept studies for therapeutic purposes. Visit http://www.invivobiosystems.com/longevity for more information.

About Lifeist Wellness Inc.Sitting at the forefront of the post-pandemic wellness revolution, Lifeist is a portfolio of wellness companies leveraging advancements in science and technology to enable individuals to find their personalized path to wellness. Portfolio business units include: CannMart, which operates a B2B wholesale distribution business facilitating recreational sales to Canadian provincial government control boards and the CannMart.com marketplace which provides Canadian medical customers with a diverse selection of cannabis products from a multitude of federally licensed cultivators and its U.S. customers with access to hemp-derived CBD and smoking accessories; Australian Vapes, the countrys largest online retailer of vaporizers and accessories; Findify, a leading AI-powered search and discovery platform; and Mikra, a biosciences and consumer wellness company seeking to develop innovative therapies for cellular health and recovery.

Information on Lifeist and its businesses can be accessed through the links below:www.lifeist.com http://www.cannmart.com http://www.everyonedoesit.co.uk http://www.australianvaporizers.com.au http://www.wearemikra.com

Contacts

Lifeist Wellness Inc.Meni Morim, CEOMatt Chesler, CFA, Investor RelationsPh: 647-362-0390Email: ir@lifeist.com

Forward Looking Information

This news release contains forward-looking information within the meaning of applicable securities laws. All statements contained herein that are not historical in nature contain forward-looking information. Forward-looking information can be identified by words or phrases such as may, expect, likely, should, would, plan, anticipate, intend, potential, proposed, estimate, believe or the negative of these terms, or other similar words, expressions and grammatical variations thereof, or statements that certain events or conditions may or will happen.

The forward-looking information contained herein, including, without limitation, statements related to the launch of Mikras first product CELLF and its anticipated therapeutic benefits, are made as of the date of this press release and is based on assumptions management believed to be reasonable at the time such statements were made, including, without limitation, expectations that pre-clinical trials will prove successful and that the Companys application for a patent will be granted, expectations that CELLF will gain market acceptance along with the expansion of the market for nutraceutical products and managements perceptions of Lifeists standing in the online marketplace for wellness and related products, Lifeists beliefs regarding the expected demand for wellness and related products and the expected growth of that market, the timing of product availability, as well as other considerations that are believed to be appropriate in the circumstances. While we consider these assumptions to be reasonable based on information currently available to management, there is no assurance that such expectations will prove to be correct. By its nature, forward-looking information is subject to inherent risks and uncertainties that may be general or specific and which give rise to the possibility that expectations, forecasts, predictions, projections or conclusions will not prove to be accurate, that assumptions may not be correct and that objectives, strategic goals and priorities will not be achieved. A variety of factors, including known and unknown risks, many of which are beyond our control, could cause actual results to differ materially from the forward-looking information in this press release. Such factors include, without limitation: unforeseen developments that would delay the Companys ability to launch CELLF as anticipated and in a timely manner, the risk that pre-clinical trials are not as successful as anticipated and do not demonstrate anticipated therapeutic benefits and/or fail to strengthen the Companys patent claim, the risk that the expected demand for nutraceutical products in general and those of the Company does not develop as anticipated, regulatory risk, risks relating to the Companys ability to execute its business strategy and the benefits realizable therefrom and risks specifically related to the Companys operations. Additional risk factors can also be found in the Companys current MD&A and annual information form, both of which have been filed under the Companys SEDAR profile at http://www.sedar.com. Readers are cautioned not to put undue reliance on forward-looking information. The Company undertakes no obligation to update or revise any forward-looking information, whether as a result of new information, future events or otherwise, except as required by applicable law. Forward-looking statements contained in this news release are expressly qualified by this cautionary statement.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release or has in any way approved or disapproved of the contents of this press release.

Source: Lifeist Wellness Inc.

Photos accompanying this announcement are available at:

https://www.globenewswire.com/NewsRoom/AttachmentNg/0629e54e-48ba-4759-a4ce-344d1b6cc525

https://www.globenewswire.com/NewsRoom/AttachmentNg/4e7b131b-e5d1-4e28-a67d-7fb10c3f7dba

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Lifeist Subsidiary Mikra Cellular Sciences to Launch First Product CELLF to Combat Brain Fog and Unlock Healthy Aging, Announces U.S. Patent...

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Longevity and anti-aging research: Prime time for an …

Sunday, November 21st, 2021

Research into longevity and healthy aging has progressed rapidly in recent years, but intense interest from the public, corporations, and the media has created an environment in which unfounded claims can be hard to separate from scientific facts.

In February, a group of 16 researchers from Harvard, MIT, and other institutions around the U.S. and Europe launched the nonprofit Academy for Health and Lifespan Research to promote future work, ease collaborations between scientists, and ensure that governments and corporations are making decisions based on the latest facts instead of rumor, speculation, or hype.

The Boston-based organization will form a nexus for work on extending the human health span, fighting the myriad diseases associated with aging, and fostering the work of junior researchers. Harvard Medical School Genetics Professor David Sinclair, one of the new academys founding members and director of the Paul F. Glenn Center for the Biology of Aging at HMS, spoke to the Gazette about the status of aging research and the mission of the academy.

GAZETTE:Tell me about the academy. Is it intended to be mainly an advocacy organization?

SINCLAIR: The academy has been formed because our field of aging and longevity research has reached a point of maturity where the leaders in the field believe that we can have or will have a big impact on the planet. That impact will be in medicine, in health span, and in its knock-on effect on [everything from] human productivity to Social Security.

We wanted to come together to speak with one voice, to be able to help corporations and governments understand what things they should be thinking about now and give realistic projections of what life is going to be like 10, 20, 50 years from now. Because its not a question of if theres going to be an impact, its really a question of what kind of a future we want to build when this happens.

GAZETTE: What kind of impact are we talking about? When you think about 10, 20, 50 years in the future, how do you see aging being transformed in the U.S. and around the world?

SINCLAIR: The 16 researchers in the academy have all been working on this for most, if not all, of our careers. So that spans for many of us over 25 years. When we started, research on aging at the molecular level was the backwater of biology, but in the last 25 years, aging has moved to the forefront of science. Its actually rare to open a leading scientific journal and not see a new breakthrough in our understanding of the aging process.

Recently, weve moved from being able to extend health and lifespan of simple organisms like yeast and worms and flies to being able to do this quite easily in animals, in mice and monkeys. With that knowledge how to keep the body younger and not develop diseases of aging we think its now prime time for having an impact on the globe.

By impact, I mean that instead of tackling one disease at a time, which is the way 20th-century medicine and pharmaceutical development was practiced, we believe we can [develop] medicines that will treat aging at its source and thereby have a much greater impact on health and lifespan than drugs that target a single disease.

Heart disease medicine may keep your heart healthy for an extra five or 10 years, but does nothing for your brain. So, were ending up with a population of people who live longer but not better and who need a lot of help, if theyre not completely [in the grip of] dementia. We dont think thats necessarily the only or the best approach.

Were generally in denial that, for most of the diseases that we get these days, the root cause is aging. I dont know 10-year-olds that get Alzheimers disease or heart disease.

David Sinclair

Now, we have the knowledge. Were developing the technologies to not just delay these diseases of aging but actually reverse aspects of them. Imagine you have a treatment for heart disease, but as a side effect youd also be protected against Alzheimers, cancer, and frailty. Youd live a longer and healthier life.

The reason we can extend the lifespan of animals is not because we can just make them live longer, but we keep them healthy. The animals dont get heart disease, cancer, Alzheimers, until sometimes 20 percent later in their life. And so thats 20 percent longer youth, not just 20 percent longer life.

GAZETTE: Are there regulatory hurdles? When weve spoken in the past, youve mentioned that the FDA considers aging a natural process and therefore wont approve drugs to treat it. Are we at a point where that is becoming a hurdle in getting advances out to the people who need them?

SINCLAIR: Opinions are changing rapidly about whether aging should be a condition that a doctor can prescribe a medicine for. Thats essentially what a disease is. Its something that a doctor can read the label that this medicine is for aging or age-related conditions. Were not at that point yet.

We currently live in a world where aging is so common that its considered by most of the world, including the medical community, as something thats natural and inevitable. And if somethings considered inevitable, typically you dont focus on it in the same way as something you can treat. Cancer was a natural part of life at one time, in the same way that aging is today. A hundred years ago, doctors didnt focus on treating cancer as much as we do now, because then you couldnt do much, if anything, about it. As soon as you show you can modify the disease process, like we learned in the 1970s with the discovery of oncogenes that cause cancer and increasingly so today then theres renewed hope, and views about the condition shift.

There are now dozens of companies working on therapies that could potentially extend overall human health and lifespan, but none of them are working specifically toward an approval for aging because the FDA wouldnt even know where to start. But that may be changing quickly. Ive been part of a group that talked with the FDA, and they are willing and also quite enthusiastic about considering a change that defines aging as a disease. They would like us, first, to show that its possible to change the rate of aging, which in my view is backward, but thats what they want.

In Australia, the government is 100 percent behind this, at the FDA level and in the Ministry for Health. Im hopeful that one country in the world it may be Australia, it may be the U.S., it may be an Asian country will change its definition of aging. Once one country changes its definition, then it will be a domino effect and the others will follow.

One of the biggest changes that happened last year was the World Health Organization, in their international disease codebook, declared aging a condition that is treatable. So now doctors and countries can report back to the World Health Organization how many people in their country are suffering from this condition known as old age.

Were generally in denial that, for most of the diseases that we get these days, the root cause is aging. I dont know 10-year-olds that get Alzheimers disease or heart disease. Its aging that increases the risk 1,000-fold for cancer, while if you smoke, it goes up fivefold. Which is more important to be focused on?

GAZETTE: What excites you most about the state of anti-aging and longevity research?

SINCLAIR: Well, I hate to pick favorite children. Someone will always be upset. I have my hands in a few pies, but the most recent one that Im excited about is cellular reprogramming.

GAZETTE:And how does that occur?

SINCLAIR: We introduce a combination of genes into the animal, or the cell, and we see that the tissue is rejuvenated as though it was young again. So it can heal, it can start new growth, like it was young. And if we can figure out how to deliver that to patients in a safe way, then its quite possible that aging is a reversible disease.

GAZETTE: What genes are we changing?

SINCLAIR: Were using a combination of Yamanaka factors [used to reprogram differentiated adult cells into induced pluripotent stem cells] that are used to make stem cells currently in a dish, but what were finding is that you can introduce them into the animal as well. They tolerate it well and tissues rejuvenate.

I havent published it yet, so I cant say too much, but were writing up the paper now that shows that parts of the mouses body that we thought would not ever improve are able to be regenerated. So were licensing that technology and hoping that it will be tested in the clinic in the next two years.

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North American South Devon Association

Sunday, November 21st, 2021

In the beef cattle industry today, South Devon cattle deliver necessary traits for success. They are an English breed that can outcross with other English and Continental cattle breeds.

Tests and years of selective breeding on five continents show that South Devon cattle are feed efficient, fertile and maternal, with superior carcass traits. They are well-known for their longevity and 100s of years of docility are bred right into their genetics.

These economically important traits combine a uniform approach and balance to commercial and registered ranching and feeding operations with the use of South Devon genetics.

Profit driven cow/calf operations are looking for a level of fertility, low feed intake, high weaning weight production and calf value that South Devon can deliver. In the feedlot, lower feed intake and carcass merit are a compliment of the South Devon breed.

In North America South Devon cattle are primarily polled and can be found in black or red-hided genetics.

Cattle operations using South Devon genetics can increase their profitability with a breed suitable for any North American geographic location.

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Can drinking red wine ever be good for us? – BBC Future

Sunday, November 21st, 2021

The researchers also found that people who drank red wine had a lower body mass index (BMI). This also could be why drinking red wine in moderation is associated with health. Its not that red wine makes you healthier; its that red wine drinkers may be healthier to begin with.

People who drink red wine often also do more exercise and [are] more affluent and healthier, says Bellis.

The same is true of the gut health question: because the study was observational, the researchers couldnt establish whether a single glass of red wine a week makes your gut healthier, or people with healthier guts happened to be the kind to drink a glass a week. And randomised control trials, where participants are split into groups and their health measured as they follow different diets, can be particularly unethical when it involves alcohol.

There have been a few randomised control trials but these have been less than conclusive. A 2016 study found that having one glass of red wine with their evening meal every day for six months didnt affect the blood pressure of people with diabetes.

Another randomised control study from 2015 found that drinking 150ml of red wine (again, the amount held in a champagne flute), can lower the risk of developing stroke and heart disease among people with diabetes.

Healthiest option

In fact, while red wine may be the healthiest drink option, its healthier to abstain entirely, says author of the study looking at wine consumption and gut health, Caroline Le Roy, research associate at the Department of Twins Research at Kings College London.

We know alcohol is bad for us, she says. If you drink, it should be red wine, as this is the only alcoholic drink thats been found to have a beneficial effect, but Im not encouraging people to drink red wine.

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Gero scientists found a way to break the limi | EurekAlert!

Sunday, November 21st, 2021

image:Schematic illustration of loss of resilience along aging trajectories view more

Credit: GERO PTE. LTD.

The research team of Gero, a Singapore-based biotech company in collaboration with Roswell Park Comprehensive Cancer Center in Buffalo NY, announces a publication in Nature Communications, a journal of Nature portfolio, presenting the results of the study on associations between aging and the loss of the ability to recover from stresses.

Recently, we have witnessed the first promising examples of biological age reversal by experimental interventions. Indeed, many biological clock types properly predict more years of life for those who choose healthy lifestyles or quit unhealthy ones, such as smoking. What has been still unknown is how quickly biological age is changing over time for the same individual. And especially, how one would distinguish between the transient fluctuations and the genuine bioage change trend.

The emergence of big biomedical data involving multiple measurements from the same subjects brings about a whole range of novel opportunities and practical tools to understand and quantify the aging process in humans. A team of experts in biology and biophysics presented results of a detailed analysis of dynamic properties of the fluctuations of physiological indices along individual aging trajectories.

Healthy human subjects turned out to be very resilient, whereas the loss of resilience turned out to be related to chronic diseases and elevated all-cause mortality risks. The rate of recovery to the equilibrium baseline level after stresses was found to deteriorate with age. Accordingly, the time needed to recover was getting longer and longer. Being around 2 weeks for 40 y.o. healthy adults the recovery time stretched to 6 weeks for 80 y.o. on average in the population. This finding was confirmed in two different datasets based on two different kinds of biological measurements - blood test parameters on one hand and physical activity levels recorded by wearable devices on the other hand.

"Calculation of resilience based on physical activity data streams has been implemented in GeroSense iPhone app and made available for the research community via web-based API." - commented the first author of the study, Tim Pyrkov, head of the mHealth project at Gero.

If the trend holds at later ages, the extrapolation shows a complete loss of human body resilience, that is the ability to recover, at some age around 120-150 y.o. The reduced resilience was observed even in individuals not suffering from major chronic disease and led to the increase in the range of the fluctuations of physiological indices. As we age, more and more time is required to recover after a perturbation, and on average we spend less and less time close to the optimal physiological state.

The predicted loss of resilience even in the healthiest, most successfully aging individuals, might explain why we do not see an evidential increase of the maximum lifespan, while the average lifespan was steadily growing during the past decades. The divergent fluctuations of physiological indices may mean that no intervention that does not affect the decline in resilience may effectively increase the maximum lifespan and hence may only lead to an incremental increase in human longevity.

Aging in humans is a complex and multi-stage process. It would, therefore, be difficult to compress the aging process into a single number, such as biological age. Gero's work shows that longitudinal studies open a whole new window on the aging process and produce independent biomarkers of human aging, suitable for applications in geroscience and future clinical trials of anti-aging interventions.

"Aging in humans exhibits universal features common to complex systems operating on the brink of disintegration. This work is a demonstration of how concepts borrowed from physical sciences can be used in biology to probe different aspects of senescence and frailty to produce strong interventions against aging.", - says Peter Fedichev, co-founder and CEO of Gero.

Accordingly, no strong life extension is possible by preventing or curing diseases without interception of the aging process, the root cause of the underlying loss of resilience. We do not foresee any laws of nature prohibiting such an intervention. Therefore, the aging model presented in this work may guide the development of life-extending therapies with the strongest possible effects on healthspan.

"This work by the Gero team shows that longitudinal studies provide novel possibilities for understanding the aging process and systematic identification of biomarkers of human aging in large biomedical data. The research will help to understand the limits of longevity and future anti-aging interventions. What's even more important, the study may help to bridge the rising gap between the health- and life-span, which continues to widen in most developing countries." - says Brian Kennedy, Distinguished Professor of Biochemistry and Physiology at National University Singapore.

"This work, in my opinion, is a conceptual breakthrough because it determines and separates the roles of fundamental factors in human longevity - the aging, defined as progressive loss of resilience, and age-related diseases, as "executors of death" following the loss of resilience. It explains why even most effective prevention and treatment of age-related diseases could only improve the average but not the maximal lifespan unless true antiaging therapies have been developed" - says prof. Andrei Gudkov, PhD, Sr. Vice President and Chair of Department of Cell Stress Biology at Roswell Park Comprehensive Cancer Center, a co-author of this work and a co-founder of Genome Protection, Inc., a biotech company that is focused on the development of antiaging therapies/.

"The investigation shows that recovery rate is an important signature of aging that can guide the development of drugs to slow the process and extend healthspan." - commented David Sinclair, Harvard Medical School professor of genetics.

"The research from Gero surprisingly comes to a similar quantification of human resilience - a proposed biomarker of ageing - based on two very different kinds of data: blood test parameters on one hand and physical activity levels recorded by wearable devices on the other hand. I'm very excited to see how Person-generated Health Data, including data from commercial wearables, can help create individual, longitudinal profiles of health that will be instrumental to shed light on lifetime-scale health phenomena, such as ageing." - commented Luca Foschini, Co-founder & Chief Data Scientist at Evidation Health.

Two aging markers

The authors characterized the dynamics of physiological parameters on time scales of human lifespan by a minimum set of two parameters. The first is an instant value, often referred to as the biological age, and is exemplified in this work by the Dynamic Organism State Index (DOSI). The quantity is associated with stresses, lifestyles and chronic diseases and can be computed from a standard blood test.

The other parameter - the resilience - is new and reflects the dynamic properties of the organism state fluctuations: it informs how quickly the DOSI value gets back to the norm in response to stresses.

When does aging start?

Age-related changes in physiological parameters start from birth. However, various parameters change in different ways at different stages of life, see, e.g., a previous work by the same authors published in Aging US in 2018).

The data from the Nature Communications work shows that there is a good differentiation between the growth phase (mostly complete by the age of 30 and following the universal growth theory by Geoffrey West and aging. At 40+ years, aging manifests itself as a slow (linear, sub-exponential) deviation of physiological indices from their reference values.

How often should one measure biological age?

Physiological parameters are naturally subject to fluctuations around some equilibrium level. Glucose levels rise and drop after having a meal, the number of sleeping hours is slightly different each day. Yet, one can collect a longitudinal dataset, that is a series of such measurements for the same person, and observe that the average levels are different between individuals. Resilience also requires repeated measurements, since one needs to know exactly when recovery was achieved to calculate the resilience.

Importantly, resilience also provides a convenient guide on how often repeated measurements should be taken. As a rule of thumb, the period of observation required for the robust bioage determination should comprise multiple stress and recovery events. For the most healthy individuals such an observation period would amount to several months and should increase with age. During that time, a robust bioage determination would require several data points per recovery time, that is ideally one measurement in a few days.

Wearable technology comes into play

In 2021, the only practical way to achieve a high (once-per-day or better) sampling rate is to use mobile/wearable sensor data.

In another paper, the authors have focused on wearable/mobile sensor data. They have built "wearable DOSI", which they called GeroSense and reported its validation tests in Pyrkov et al. Aging (Albany NY) 13.6 (2021): 7900. GeroSense can be used to compute resilience. Population study shows that the number of individuals showing signs of the loss of resilience increases exponentially with age and doubles every 8 years at a rate matching that of the Gompertz mortality law (the observation by B. Gompertz from 1827, who observed for the first time that the all-cause mortality rate doubles every 8 years).

###

About Gero

Gero is a data-driven biotech company applying modern AI/ML tools to big longitudinal biomedical data to understand aging and major diseases.

Gero AI/ML models are originating from the physics of complex dynamic systems. We have presented our unique approach in Frontiers in Genetics (Fedichev 2018, Frontiers in genetics 9:483). We combine the potential of deep neural networks with the physical models to study human health as a dynamic process. In conjunction with high-quality genetics data, we produce quantitative explanatory models of (aka theory of) aging and complex diseases, as well as actional drug target hypotheses.

Gero conducts high-quality research in collaborations with Harvard Medical School, Massachusetts Institute of Technology, University of Edinburgh, National University of Singapore, Moscow Institute of Physics and Technology, and Roswell Park Comprehensive Cancer Center. The company is a regular contributor to peer-reviewed journals.

Gero has developed a unique framework "GeroSense" for continuous day-to-day monitoring of biological age based on data streams of mobile and wearable sensors. "GeroSense" provides biological age monitoring in our free iPhone app.

Gero encourages using "GeroSense" via web API for monitoring of anti-aging and pro-longevity effects of therapies as well as lifestyle choices, physical activities, diets, food supplements, recommended by health/fitness and wellness apps (see https://techcrunch.com/2021/05/07/longevity-startup-gero-ai-has-a-mobile-api-for-quantifying-health-changes/).

Gero is funded by AI champions, including AIMATTER founders (recently acquired by Google). In 2019 and 2021, Gero was also named one of the leading companies in artificial intelligence in life extension along with Google and IBM.

About Roswell Park Comprehensive Cancer Center

Roswell Park Comprehensive Cancer Center is a community united by the drive to eliminate cancer's grip on humanity by unlocking its secrets through personalized approaches and unleashing the healing power of hope. Founded by Dr. Roswell Park in 1898, it is the only National Cancer Institute-designated comprehensive cancer center in Upstate New York. Learn more at http://www.roswellpark.org, or contact us at 1-800-ROSWELL (1-800-767-9355) or ASKRoswell@RoswellPark.org.

Nature Communications

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In most ways, women age better than men and live longer. Scientists are trying to figure out why. – The Philadelphia Inquirer

Sunday, November 21st, 2021

Consider 100 baby boys and 100 baby girls born in 1950. Experts predict that 46 of the men and 61 of the women a third more will still be alive at age 80 in 2030.

Even Steven Austad, an expert on aging at the University of Alabama at Birmingham, didnt give statistics like that much thought until about 10 years ago. Everyone knew that women outlived men. He figured it was just because men had more heart disease.

But Austad, who is senior scientific director of the American Federation for Aging Research, is a sucker for topics that others take for granted, and he dug deeper. He learned that girls started out-surviving boys even before they were born and that their survival advantage lasted throughout life. It was present in virtually every country, rich or poor. Women were more likely to live through natural disasters, famines, pandemics (including COVID-19) and many of the diseases that most often kill human beings. Under almost any condition we can imagine, women do better, he said.

A rare upside for men was that those who made it to their senior years were less disabled than female peers. There were also surprising studies that found that a few drugs that extended the life of male mice did nothing for females. Thats a really stunning result, said Richard Miller, a biogerontologist who directs the Paul F. Glenn Center for Aging Research at the University of Michigan and has been studying life-extending drugs in mice. One medication, he said, worked in both sexes.

Austad and a growing cadre of researchers started to think that these differences in aging between men and women were fundamental to human biology and potentially much more complex and divergent than many had assumed. They are now in the early stages of studying how our chromosomes and genes, hormones and immune systems influence how long and how well we live, with an eye toward expanding our healthy lifespans.

If we could find a way to make men live as long as women and make women be as healthy as men later in life, then we would have an enormous impact on our lives, Austad said.

Candace Kerr, a stem cell biologist in the division of aging biology at the National Institute on Aging, agreed that understanding these sex differences could improve the health of both men and women as they aged. It paves the way to finding sex-specific targets for disease, she said.

For decades, scientists assumed that information they gleaned from male patients and male lab animals would naturally apply to females, as well. Since 2016, the National Institutes of Health has required scientists to incorporate males and females into the design, analysis and reporting of clinical research studies of people and vertebrate animals.

Now researchers are finding unexpected differences throughout our bodies, but they say its too soon to draw sweeping conclusions. I think that we are in a renaissance of sorts in really beginning to understand and appreciate the differences, said Dena Dubal, a neurologist at University of California-San Francisco who studies how to slow aging with a focus on hormones and genetics. Her research has found fascinating evidence of the benefits women may derive from their second X chromosome.

The signs that women are the tougher sex when it comes to health are copious. Eighty-five percent to 90% of centenarians are women. All of the worlds 10 oldest people with credible birth records were female, Austad said. In 2018, women died at a lower age-adjusted rate of 13 of the top 15 causes of death, according to the National Center for Health Statistics. There was no sex difference for stroke. Women were more likely to die of Alzheimers disease, although men who get dementia die of it more quickly, said Michelle Mielke, a Mayo Clinic epidemiologist who studies sex differences in neurodegeneration.

Women tend to die of the same basic things that men do, but they die at later ages, Miller said.

At the cellular level, womens brains look four to five years younger than mens, Dubal said. Many biological markers indicate faster aging in almost all of the tissues in male bodies, Kerr said. Women get heart disease later. Their vascular health is generally better than mens, although they have more disease in small blood vessels in late life, Mielke said. Womens immune systems respond more quickly to viral invasions. This is one explanation for why theyre more likely to recover. It may also be why theyre more prone to autoimmune diseases than men.

Then we come to what Austad calls the morbidity-mortality paradox. Men who survive into late middle age and old age tend to have less disability than women. One theory is that men die of diseases that women survive, but the women do not emerge unscathed. Many women will survive and remain fairly functional after diseases that men would have died from, Miller said.

Anne B. Newman, a geriatrician and epidemiologist at the University of Pittsburgh, added that women are more prone to arthritis, which causes disability. Everyone loses muscle mass with age, and women start out with weaker muscles and a higher percentage of body fat. Women are also more prone to osteoporosis after menopause, and that puts them at risk for broken hips. There are more older women with frailty, partly because frail men dont live long.

Women are just physically less endowed to keep moving as they get older, Newman said.

READ MORE: It's never too late to start moving, but you may not catch up to lifelong exercisers

As to why women live longer, the theories are many and complex.

The gap between male and female lifespan widened during the 20th century. Caleb Finch, a biologist at the University of Southern California who studied that phenomenon, thought lung cancer and heart disease accounted for most of the difference. He also studied an indigenous Bolivian population whose pre-industrial lifestyle included exercise and a healthy diet. People there had very little coronary artery disease, but men still had more evidence of blood vessel damage than women.

Newman added that women began living longer when better medical care meant they less often bled to death or became infected during childbirth. She thinks that qualities that allow women to successfully carry a child, such as the ability to tolerate stress and store additional nutrition, may lengthen their lifespans.

You cant ignore behavior. Men are more likely to smoke and eat fatty food. Theyre also less likely to see doctors regularly and get cancer screenings and flu and COVID-19 vaccines. They more often age in isolation. Behavior feels like more than half of the picture, said Aroonsiri Howell, a Temple Health geriatrician.

Young men are prone to risky and potentially deadly activities, a period that Austad calls testosterone dementia. Their death rate compared to womens slows after 35 or so, but its still higher.

Finch said trying to tease out whats affecting our aging is like analyzing a hoard of arrows shot into the air at the same time but traveling at different rates. Genes and hormones matter, but the role of culture and society in shaping the outcomes is also huge and not easy to define at the molecular level.

Beyond behavior, much current research focuses on hormones and sex chromosomes. Women have two X chromosomes, one from their mother and one from their father. Men have an X from their mother and a Y from their father.

Those two Xs give women a richer dose of X-related genes. In each cell of a womans body, one X dominates and the other is mostly inactivated, but its not always the same X. Early in life, the mom and dad Xs may split the work fairly evenly, but, as women age, the fitter X may take on a bigger role, Austad said. Plus, scientists now know that the inactivated X isnt really inactivated. About 15% of its genes are functional.

Austad thinks the Y deserves more attention than scientists are giving it, but its clear that it codes for many fewer genes (55) than the X (900). While the second X may give women a safety net of sorts if one of their Xs is faulty, a mans Y chromosome is not much help when theres a problem with his X. This is why certain X-lined diseases, such as fragile X syndrome, hemophilia A, and Duchenne muscular dystrophy are more common in men.

Dubals work with mice suggests that womens extra X complexity also gives women a longevity advantage. She used a technique that allows researchers to grow the gonads of one sex in the bodies of another, thus exposing them to the other sexs hormones. So, genetically female mice could have testicles and penises and male mice could have ovaries and vaginas. She compared four groups of mice: XX mice with ovaries, XX mice with testicles, XY mice with testicles and XY mice with ovaries. The XX mice lived the longest, regardless of their gonads.

The X accounts for about 5% of our genome, Dubal said, and it is rich in brain-related genes. This may help explain why women are more cognitively resilient. One of her studies found that 19 of those genes were associated with slower cognitive aging in women, but not in men. Three genes, meanwhile, were linked to higher levels in men but not women of misformed tau, a protein seen in the brains of people with Alzheimers.

Women may reap the benefits of the double-dose of X throughout their lives, but theres little doubt that things go downhill from an aging perspective after menopause, so hormones are clearly also a factor. Estrogen, the most important female hormone, drops markedly as a woman enters menopause. Testosterone production also slows in men.

Estrogens are thought to be protective against a variety of diseases, whereas testosterone seem to enhance the risk of disease progression, wrote Brnice Benayoun, a geneticist and cell biologist at the University of Southern Californias Leonard Davis School of Gerontology, in a 2020 paper.

The average woman reaches menopause at 51. Studies show that later menopause is associated with longer life.

Jennifer Garrison, a neuroscientist and chemist at the Buck Institute for Research on Aging, focuses on the impact of ovarian aging in women. Menopause makes a womans body age about 6% faster, she said. It unleashes this negative cascade of health effects, including more heart disease, cognitive decline, and bone weakening. She said the ovaries are involved in important communication channels with the brain that have systemic physical implications.

She would like to do away with menopause entirely. Theres no biological imperative to have it, she said. She thinks menopause should be a choice, not something imposed on you by some out-of-date biology. She realizes that not every woman dreams of extra decades of periods and pregnancy fears. Pregnancy and fertility and menstruation can potentially be uncoupled from having functioning ovaries, she said.

No doubt it will take a while to figure out how to do that, and there is no similar fix available to aging men.

In the meantime, Temples Howell counsels male and female patients differently. She tells the men to worry about heart disease and high-fat diets. Women need to worry about preventing osteoporosis and falls.

READ MORE: Steps to prevent falls as we age

And we all can do the usual things that promote healthier aging: Eat good food, avoid smoking and exercise.

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In most ways, women age better than men and live longer. Scientists are trying to figure out why. - The Philadelphia Inquirer

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Embark sponsors The National Dog Show, in commitment to improving life and longevity of all dogs – PRNewswire

Sunday, November 21st, 2021

BOSTON, Nov. 16, 2021 /PRNewswire/ -- Embark Veterinary, Inc., a global leader in dog genetics, today announced that it will be the preferred dog DNA test sponsor of The National Dog Show. Hosted by The Kennel Club of Philadelphia and licensed by the American Kennel Club, the 20th anniversary Thanksgiving Day special will take place at the Greater Philadelphia Expo Center in Oaks, Pa. Nov. 20-21. It will be open to the vaccinated public for the first time since 2019 due to the COVID-19 pandemic.

Embark recently launched the first-ever DNA test for purebred pet owners, leading the dog DNA testing evolution from breed discovery to a personalized pet care necessity. Embark's data shows that 75% of dogs are carriers, or at risk for, a genetic health condition. But, with hundreds of actionable health insights and the most accurate, detailed data on their dog's health, Embark is helping breeders, owners, and veterinarians make proactive choices that address any breed-specific health conditions and traits.

"The National Dog Show Presented by Purina is a Thanksgiving tradition for many families, and we're proud to become a part of that tradition this year," said Embark CEO and Cofounder Ryan Boyko. "One of the silver linings of the pandemic has been the opportunity to better understand, appreciate and bond with our dogs. As families come together to watch The National Dog Show this year, we hope they'll consider learning more about how to improve their dog's health through genetic screening."

Embark aims to extend dogs' lives by three years within the next decade. A key to achieving that goal is building tools that help breeders make better mating pairs that improve the health of their breeding line, offering genetic counseling, and screening for breed-relevant genetic health conditions. Embark salutes the breeders exhibiting at the Kennel Club of Philadelphia dog show and their important work in breed preservation.

"We are looking forward to working with Embark Veterinary in support of the important work that they do for our canine friends, pet parents, and the veterinary community," said Kennel Club of Philadelphia President Wayne Ferguson. "There's great interest in canine genetics and show attendees in Philadelphia will have the opportunity to learn more at the Embark expo booth."

About Embark Embark Veterinary, Inc. was launched in 2015 by two brothers, Adam and Ryan Boyko, who have a passion for scientific research and a lifelong love for dogs. Starting with their best-in-class canine DNA test, Embark is building a powerful platform for scientific discovery that will accelerate advancements in personalized dog care. Embark offers the most scientifically advanced, most trusted, and highest-rated dog DNA tests on the market that helps dog owners, breeders, and veterinarians learn about their dog's breed, health, and ancestry. Customers gain hundreds of actionable insights that inform more proactive care, and every test fuels new research to help all dogs lead longer, healthier lives. Embark is an official research partner of Cornell University College of Veterinary Medicine, was named to the Inc. 5000 list for the past two years, and was included on Forbes' next billion-dollar startups list.

For more information, visit Embark's website at EmbarkVet.com, and follow Embark on Facebook, Twitter, and Instagram.

SOURCE Embark Veterinary Inc.

http://EmbarkVet.com

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Embark sponsors The National Dog Show, in commitment to improving life and longevity of all dogs - PRNewswire

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Inherited Metabolic Disorders Market Study | Know the prominent factors that will help in reshaping the market growth – BioSpace

Sunday, November 21st, 2021

The inherited metabolic disorders market lies mostly with the Caucasian and African American populations of world, especially in North America, Europe, Australia, and Africa, followed by the minority populations from South Asia and East A.

Globally, IMD affects nearly one in every 2,500 to 5,000 individuals with nearly 300 to 600 new cases found in the U.K., according to Public Health Genetics U.K. The specificity and high risk affinity of IMD varies from disorder to disorder, with some disorders like familial cylomicronemia being closely associated with Caucasians and others like porphyria being recoded largely among African Americans. These metabolic disorders are often controllable with certain lifestyle and diet changes, including Familial Cylomicronemia and Phenylketonuria. But some IMDs are highly dangerous and may affect the survivability of a person, such as Huntingtons or Zellweger syndrome.

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A lot of IMDs arise when the mutated gene responsible is inherited by the natural selection process and a large number of these genes are recessive. This is probably why a large number of these metabolic disorders are rare occurrences, whereas certain other genes are dominant in nature; this makes it difficult for a willing parent to conceive a child as the risk for transferring a gene remains high (e.g. Huntingtons). Familial chylomicronemia occurs when an individual genetically inherits Lipoprotein lipase enzyme mutation. This is a very rare genetic disease at occurrence rate of 1 individual per million with chances of symptoms occurring only in homozygous individuals (receiving mutation genes from both parents) or in other words recessive gene transmission.

Global Inherited Metabolic Disorders Market: Current Market Trends

Nowadays, genetic screening via mass spectrometry and DNA testing of all newborn children are done in nearly all of the developed countries and also some developing countries of the world, including India, China, and Brazil, albeit across a small percentage of the national population. This prepares a parent and the child with the necessary precautions and treatment for increasing the longevity of the concerned newborn. The life expectancy of such a child with all the necessary care and precaution is at par with the average individual.

However among many adult populations and in some children, rare genetic metabolic disorders are abruptly presented and often not accurately diagnosed. In such individuals, abnormal metabolic changes are considered to be a type of genetic mutation in routine diagnosis. Symptoms such as growth failure, precocious puberty and development delay in children below 12, and anemia, neurological disorder, cancer, muscle weakness, rapid hormonal changes, and skin changes in adults, are regarded to probably have a genetic metabolic cause.

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Global Inherited Metabolic Disorders Market: Treatment Classifications

The treatment of IMDs is broadly classified into dietary restrictions, dietary supplementation, drugs that inhibit or regulate metabolism, transplantation of the concerned organ, gene therapy, and dialysis in severe cases. In the case of familial cylomicronemia, gene therapy includes Alipogene tiparvovec recombinant gene therapy drug, manufactured by UniQure Inc. This therapy utilizes viruses (adenovirus vector) designed in such a way that upon infection, the gene for producing the lipoprotein lipase is induced into the host cell, thereby producing the enzyme in-vivo. This therapy has shown positive results and is expected to be released into the market soon. For now, the global inherited metabolic disorders Market lies broadly in the dietary supplements market.

Global Inherited Metabolic Disorders Market: Regional Evaluation

The overall estimated global populations of IMD individuals lie in few millions. The niche category of this segment gives little market for specific condition-related products. However, the implications of therapy are huge as some treatments have the potential to completely eradicate these disorders. Several suitable models have been considered for the treatment of hypercholesterolemia and dyslipidemia, which can in turn alter the outcome of cardiovascular diseases to a bare minimum in the future. For now, the inherited metabolic disorders is open for limitless possibilities.

The inherited metabolic disorders lays primarily with the Caucasian and African American populations of world, especially in North America, Europe, Australia, and Africa, followed by the minority populations from South Asia and East Asia.

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Current and Future Threats

Along with studying the opportunities necessary for growth, threats are also an important aspect to look upon for the companies and stakeholders in a specific sector. TMR Research studies every negative aspect that will hinder the growth of a specific area of business and includes it in the report. The stakeholders and CXOs will have the benefit of assessing the threat and take the necessary steps to prevent the hindrance caused due to the threats.

Accurate Trend Analysis

Keeping up with the latest trends is crucial in any business or sector. While stakeholders are aware of the trends that are on the surface, TMR Researchers find trends that are deeply entrenched in the particular market or sector. The reports are constantly updated with the latest trends so that the stakeholders and CXOs can derive benefits from the trends and generate good revenues.

Regional Assessment

Demography forms an important part of the growth pattern of all the markets. Diving deep into the demographics enables maximum output from specific areas. The TMR Research team assesses every region and picks out the vital points that have a large impact on the growth of a market.

Industrial Analogy

The analysts at TMR Research conduct an all-round analysis on the competitive landscape of the market. The observations recorded by the analysts are added to the reports so that every stakeholder gets a glimpse of the competitive scenario and frame their business plans according to the situation.

COVID-19 Impact

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Inherited Metabolic Disorders Market Study | Know the prominent factors that will help in reshaping the market growth - BioSpace

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Why Hangovers Get Worse as You Age, and What to Do About It – Livestrong

Sunday, November 21st, 2021

For a variety of reasons, it takes your body longer to process alcohol as you get older.

Image Credit: AzmanL/E+/GettyImages

The only thing worse than a fun night of cocktails coming to an end is the morning after: when your mouth is as dry as the Sahara, your head feels like it's being used as a bass drum and your insides are churning. You're no stranger to being hungover, but that's the thing why do hangovers now feel so much worse compared to when you were younger?

There's a reason (well, several), and we'll get there but first, a quick brush-up on what causes hangovers:

"There are many different reasons why hangovers occur, and these are due to both the direct actions that alcohol has on the body as well as the way your body metabolizes and gets rid of the alcohol," Heather Moday, MD, Philadelphia-based physician and author of The Immunotype Breakthrough, tells LIVESTRONG.com.

Usually, hangovers happen as a result of drinking excessive amounts of alcohol, but depending on what you drink, combined with your genetics, weight, overall health and even your sex, you can experience hangovers even after consuming small amounts of alcohol.

Because there are so many potential factors at play, the science behind hangovers and the role age can play in their severity is spotty at best but experts do have a few theories as to why your body doesn't react as well to that pitcher of beer anymore.

1. Your Livers Not Functioning as Efficiently

It's the liver's job to metabolize the alcohol we drink, but as we age, its ability to effectively and efficiently get the job done decreases.

"This might be caused by the fact that there's simply less blood flow going to the liver, which means the body takes more time to expel the alcohol," Hisham Korraa, MD, a psychiatry and detox medicine specialist in Newport Beach, California, tells LIVESTRONG.com.

As a result, the alcohol ends up lingering in the body longer and creating a greater blood alcohol concentration than you'd have otherwise.

2. You Have Less Total Body Water

"For the majority of our lives, the percentage of our body weight that's comprised of water is roughly 50 percent," Dr. Korraa says. "However, this starts to decline as we age, due to the overall body composition changes we experience."

We tend to develop more body fat as we age, which contains less water than lean muscle. It hasn't been proven, but some medical experts believe this can lead to there being a higher concentration of alcohol in the bloodstream, which could contribute to worse hangover symptoms.

3. Youre on Medication

Alcohol is broken down by the liver and so are many medications.

"As we get older, we have less liver enzyme activity, so being on medications while also drinking alcohol creates a competition for these enzymes," Seema Bonney, MD, founder and medical director of the Anti-Aging & Longevity Center of Philadelphia, tells LIVESTRONG.com. "This combination may contribute to more significant hangover symptoms."

Consuming alcohol while taking certain medications can also put you at risk of developing more serious health conditions, due to alcohol getting in the way of your medications breaking down properly: Sedatives become more potent, blood pressure meds aren't as effective and blood thinners can increase the risk of serious bleeding, according to the Cleveland Clinic.

4. Youre More Sensitive to the Effects of Alcohol

Odds are, you booze it up less often compared to when you were younger, thanks to an uptick in career, family and social obligations.

"Consuming alcohol less regularly might cause your body to process it slower," Dr. Korraa says. "A reduced alcohol tolerance, combined with a less productive liver, could potentially worsen hangover symptoms in older individuals."

5. Your Hangovers Might Only Seem Worse

"Because you're likely to drink less than you did when you were younger, your memory of past hangovers may be skewed," Dr. Korraa says.

Hangovers of yore may have been just as brutal as the ones you experience now, but because they're not a series regular in your life anymore and you're no longer used to them, you might perceive them as being more catastrophic.

How Long Do Hangovers Last?

The specific combination of symptoms and how severe they are vary from person to person, but hangover symptoms (headaches, dizziness, fatigue, nausea, vomiting, rapid heartbeat, irritability, anxiety and depression) typically peak when the blood alcohol concentration in the body returns to around zero, with the symptoms lasting roughly 24 hours or longer, according to the National Institute on Alcohol Abuse and Alcoholism.

How to Avoid Feeling Hungover

Drinking on an empty stomach is a recipe for hangover city.

Image Credit: skynesher/E+/GettyImages

Unfortunately, the only foolproof way to avoid a hangover is you guessed it not drinking.

"There's no absolute prevention for hangovers if you choose to drink," Dr. Moday says. "However, there are certain things to keep in mind if you do decide to imbibe."

Read on for steps you can take to make hangovers more manageable and maybe even avoidable.

1. Choose Your Drink Wisely

In terms of which alcohols may cause more hangovers, this is somewhat individual. But generally speaking, some people are sensitive to the natural tannins in red wine (chemical compounds derived from the skin, stems and seeds of grapes), as well as the added sulfites (which preserve the freshness of wine and protect it from oxidation), Dr. Moday says.

If your hangovers seem to be especially monstrous after having wine, opt for low-tannin wines like merlot, pinot noir or zinfandel, or varieties that don't contain sulfites.

Prefer liquor or beer? Avoid darker drinks, which tend to contain more congeners chemicals produced during the fermentation process.

"Higher amounts of congeners can be found in drinks like brandy, bourbon and dark ales," Dr. Korraa says. "Lighter drinks, such as gin, vodka and light beers typically have less of this chemical and are thought to be easier for the body to process, lessening the symptoms of a hangover."

2. Dont Drink on an Empty Stomach

If you eat before and while you drink, your body won't absorb the alcohol as quickly as it would on an empty stomach.

"The majority of alcohol is absorbed into the bloodstream through the small intestine," Dr. Korraa says. "If you consume a hearty meal before drinking, the alcohol will stay in your stomach longer, which means it'll be absorbed more slowly and alleviate some of the hangover side effects."

Drinking alcohol faster than your body can process it can overwhelm your system and lead to a worse hangover the next day. Spacing out your drinks might mean the difference between a mild headache and feeling like you've been hit by a bus.

"A healthy liver can process one drink per hour maximum," Dr. Moday says, so consider reading the label on your drink du jour or eyeing the volume of your glass to avoid going overboard.

One drink equals:

4. Alternate Between Booze and Water

When you drink alcohol, you may have noticed that you have to go to the bathroom more than normal.

"Because alcohol's a diuretic, you often end up expelling more liquid than you take in when you're drinking," Dr. Korraa says. Cue dehydration, which increases the odds you'll experience a bad headache, fatigue, weakness and more the following day.

For every alcoholic bevy you have, have a non-alcoholic one to balance the scales. "Doing so will increase your body's water content, which will lower your alcohol concentration," Dr. Bonney says. "It doesn't counter the absorption of alcohol but does slow it down."

5. Get a Jump on Nursing Your Hangover

While there's no guarantee, there are a few steps you can take right after drinking to potentially lessen your chances of a bad hangover the next day.

First up, do your best to finish drinking at least four hours before you go to bed. You might fall asleep faster with alcohol still in your system, but once the alcohol starts to metabolize and the sedative effect wears off, you risk waking up too early and not being able to get back to sleep.

You should also start the process of replenishing your body with fluids. "Be sure to drink a tall glass of water before going to bed," Dr. Korraa says. "You can also drink a sports drink to give your body a boost of electrolytes."

And even if the thought of eating something makes you queasy, it might be a good idea to get something bland in your system to help absorb some of the remaining alcohol in your stomach, Dr. Korraa adds. Try eating at least a plain piece of toast before calling it a night.

You should continue to rehydrate the following day. Tired of plain water? Guzzle some Gatorade or Pedialyte for a one-two punch of H2O and electrolytes.

Do your best to resist any ravenous cravings for greasy foods it's probably your blood sugar talking. Instead, opt for a breakfast that contains protein, carbs and healthy fats to bring your blood sugar back into balance.

"A nutritious breakfast with eggs, spinach, toast, bananas, avocado or oatmeal will be kinder to your stomach and may help reduce your hangover symptoms," Dr. Korraa says.

Lastly, go easy on yourself. Take time out to legitimately rest after your night of debauchery. "There's no cure for a hangover, and you truly just have to let it run its course," Dr. Korraa says. "Be kind to your body and know you'll be back to normal soon."

Link:
Why Hangovers Get Worse as You Age, and What to Do About It - Livestrong

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Addicted to coffee? Heres how it can be harmful to your health – Khaleej Times

Sunday, November 21st, 2021

Study also shows beneficial short-term health effects

By ANi

Published: Sat 20 Nov 2021, 6:20 PM

Last updated: Sat 20 Nov 2021, 6:33 PM

Coffee is the most commonly consumed beverage in the world, yet its health effects remain uncertain, says Gregory Marcus, M.D., M.A.S., associate chief of cardiology for research and endowed professor of atrial fibrillation research at the University of California, San Francisco.

While the majority of long-term observational studies have suggested multiple potential benefits of drinking coffee, this is the first randomised trial to investigate the real-time, physiologic consequences of coffee consumption.

A new research has found that caffeinated coffee consumption can have both beneficial and harmful short-term health effects.

The findings were presented at the American Heart Associations Scientific Sessions 2021.

The meeting was fully virtual Saturday from November 13-Monday to November 15, 2021, and was a premier global exchange of the latest scientific advancements, research and evidence-based clinical practice updates in cardiovascular science for health care worldwide.

Marcus and colleagues enrolled 100 adult volunteers, and they were assigned to wear continuously recording ECG devices (to track heart rhythm), wrist-worn devices to track physical activity and sleep; and continuous glucose monitors to track blood sugar levels for two weeks. The participants were an average age of 38 years, 51 per cent were women and 48 per cent were white. Researchers also obtained DNA saliva samples from the participants to assess genetic variants that may affect caffeine metabolism.

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Participants were then randomly assigned to either avoid or consume coffee for no more than two consecutive days each for 14 consecutive days. Coffee and espresso consumption were recorded in real-time via a timestamp button on the ECG monitor, and researchers tracked trips to coffee shops with geotracking. In addition, participants completed daily questionnaires to detail how much coffee they had consumed every morning.

The analysis found that coffee consumption was associated with a 54 per cent increase in premature ventricular contractions, a type of abnormal heartbeat originating in the lower heart chambers reported to feel like a skipped heartbeat. In contrast, drinking more coffee was associated with fewer episodes of supraventricular tachycardia, an abnormally rapid heart rhythm arising from the upper heart chambers.

Consuming coffee was consistently associated with more physical activity as well as less sleep. Specifically:

- Participants who consumed coffee logged more than 1,000 additional steps per day compared to days when they did not drink coffee.

- On the day participants drank coffee, they had 36 fewer minutes of sleep per night according to their Fitbit devices.

- Drinking more than one coffee drink more than doubled the number of irregular heartbeats arising from the hearts lower chambers.

- Each additional cup of coffee consumed was associated with nearly 600 more steps per day and 18 fewer minutes of sleep per night.

- There were no differences in continuously recorded glucose measured when the study participants consumed versus avoided coffee.

These findings were corroborated by analyses of adherence to their randomization assignment and amplified when more versus less coffee was consumed.

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More physical activity, which appears to be prompted by coffee consumption, has numerous health benefits, such as reduced risks of Type 2 diabetes and several cancers, and is associated with greater longevity, Marcus said. On the other hand, reduced sleep is associated with a variety of adverse psychiatric, neurologic and cardiovascular outcomes. More frequent abnormal heartbeats from the upper heart chambers influence risk of atrial fibrillation, and more frequent abnormal beats from the lower chambers, or ventricles, increase the risk of heart failure. These results highlight the complex relationship between coffee and health.

The study participants with genetic variants associated with faster caffeine metabolism exhibited more abnormal heartbeats originating in the ventricles, or PVCs when more caffeinated coffee was consumed. The slower an individual metabolises caffeine based on their genetics, the more sleep they lost when they drank caffeinated coffee.

The investigators also sought to determine if changes in exercise or sleep influenced coffees effects on abnormal heart rhythms, and no such association was identified.

Marcus noted that because coffee was randomly assigned to the study participants, cause-and-effect can be inferred. These observations were made during repeated assessments of days when coffee was consumed versus when it was not for each study participant, eliminating concerns regarding differences in individual-level characteristics as an explanation for these results.

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Addicted to coffee? Heres how it can be harmful to your health - Khaleej Times

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The Bat Elixir: Geneticists Suspect that the Flying Mammal Holds the Key to Extended Healthy Life | The Weather Channel – Articles from The Weather…

Monday, August 30th, 2021

A bat in flight.

Bats have developed a pretty bad rap sheet in the last few years. First, pop culture painted these mammals as a form of the blood-sucking Dracula, and then they were villainised for allegedly triggering a pandemic. Indeed, these poor creatures can't seem to catch a break! Aside from being adorable, bats have several other redeeming qualities like being the only mammals capable of flying and finding food even in complete darkness.

Of late, experts in genetics have uncovered a few startling facts about these Chiropterans, which could imply that they may hold the secret to healthy ageing. With the COVID-19 pandemic turning the spotlight on bats, their unique ability to stay alive against unmatched odds has also come under scrutiny.

The relationship between the size of a mammal, its metabolism, and lifespan is relatively straightforward. The larger the mammal, the slower its metabolism is, and this means a longer lifespan. While we humans ourselves are an exception to this rule, these flying mammals also deviate from this trend.

Some bats are known to live for 40 yearsthat's eight times longer than the lifespan of other animals their size! This unusually long lifespan of bats has always aroused the curiosity of scientistsit prompted them to ask the question, what was it that made these bats live longer?

The gene expression pattern in bats is very unique and has been associated with DNA repair, autophagy, immunity and tumour suppression, ensuring an extended health span for bats. Now, scientists are wondering if we could replicate a few such attributes on humans as well!

There's a cap-like structure called the telomere present at the end of each chromosomea microscopic threadlike part of the cell that carries part or all of the genetic material. This unique structure protects your chromosomes from damage. Every time your cells replicate, the chromosome loses just a little bit of the telomere. As time passes, this telomere gets very short, and either rides the wave of ageing or causes the cell to self-destruct. To put it succinctly, the shortening of your telomeres is why you age.

While this seems inevitable, studies conducted in the last few years revealed that the telomeres do not shorten in long-lived species of batslike the Myotis genus. This means that these species can protect their DNA for an unusually long-time in their lifespan.

A bat pup.

It's common knowledge that in humans, the body's ability to heal and repair any damage decreases considerably as we age. But researchers studied the genome of young, middle-aged, and old bats and found that their ability to repair DNA and damage caused by age increased as they grew older.

Another quality that contributes to their longevity is their ability to control their immune responses. With an over-excited immune response, humans tend to succumb to infections like COVID-19 quicker. In COVID-19 patients with regulated immune responses, the risk of ending up on the ventilator is much lower, reveals research.

Similarly, a controlled immune response could be why bats are able to carry numerous deadly pathogens like the coronavirus without succumbing to them easily.

Humans and bats have many similar genes but with a tweak here and a nip there. So, if we could someday discover what factors elicit these controlled immune responses and telomere shortening avoidance in bats and replicate it in humans, it would be a massive leap towards the utopian dream of a healthy, long life!

**

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Animal Expert Shares 5 Things That Will Help Your Dog Live a Longer, Healthier Life – ScienceAlert

Monday, August 30th, 2021

As anyone who has ever lived with a dog will know, it often feels like we don't get enough time with our furry friends. Most dogs only live around ten to 14 years on average though some may naturally live longer, while others may be predisposed to certain diseases that can limit their lifespan.

But what many people don't know is that humans and dogs share many genetic similarities including a predisposition to age-related cancer. This means that many of the things humans can do to be healthier and longer lived may also work for dogs.

Here are just a few ways that you might help your dog live a longer, healthier life.

One factor that's repeatedly linked with longevity across a range of species is maintaining a healthy bodyweight. That means ensuring dogs aren't carrying excess weight, and managing their calorie intake carefully.

Not only will a lean, healthy bodyweight be better for your dog in the long term, it can also help to limit the impact of certain health conditions, such as osteoarthritis.

Carefully monitor and manage your dog's bodyweight through regular weighing or body condition scoring where you look at your dog's physical shape and "score" them on a scale to check whether they're overweight, or at a healthy weight. Using both of these methods together will allow you to identify weight changes and alter their diet as needed.

Use feeding guidelines as a starting point for how much to feed your dog, but you might need to change food type or the amount you feed to maintain a healthy weight as your dog gets older, or depending on how much activity they get.

Knowing exactly how much you are feeding your dog is also a crucial weight-management tool so weigh their food rather than scooping it in by eye.

More generally, good nutrition can be linked to a healthy ageing process, suggesting that what you feed can be as important as how much you feed. "Good" nutrition will vary for each dog, but be sure to look for foods that are safe, tasty and provide all the nutrients your dog needs.

Exercise has many physiological and psychological benefits, both for our dogs (and us). Physical activity can help to manage a dog's bodyweight, and is also associated with anti-ageing effects in other genetically similar species.

While exercise alone won't increase your dog's lifespan, it might help protect you both from carrying excess bodyweight. And indeed, research suggests that "happy" dog walks lead to both happy dogs and people.

Ageing isn't just physical. Keeping your dog's mind active is also helpful. Contrary to the popular adage, you can teach old dogs new tricks and you might just keep their brain and body younger as a result.

Even when physical activity might be limited, explore alternative low-impact games and pursuits, such as scentwork that you and your dog can do together. Using their nose is an inherently rewarding and fun thing for dogs to do, so training dogs to find items by scent will exercise them both mentally and physically.

Other exercise such as hydrotherapy a type of swimming exercise might be a good option especially for dogs who have conditions which affect their ability to exercise as normal.

Like many companion animals, dogs develop a clear attachment to their caregivers. The human-dog bond likely provides companionship and often, dog lovers describe them as a family member.

A stable caregiver-dog bond can help maintain a happy and mutually beneficial partnership between you and your dog. It can also help you recognize subtle changes in your dog's behavior or movement that might signal potential concerns.

Where there is compatibility between caregiver and dog, this leads to a better relationship and even benefits for owners, too, including stress relief and exercise. Sharing positive, fun experiences with your dog, including playing with them, are great for cementing your bond.

Modern veterinary medicine has seen substantial improvements in preventing and managing health concerns in dogs. Successful vaccination and parasite management programs have effectively reduced the incidence of disease in both dogs and humans including toxocariasis, which can be transmitted from dog feces to humans, and rabies, which can be transmitted dog-to-dog or dog-to-human.

Having a good relationship with your vet will allow you to tailor treatments and discuss your dog's needs. Regular health checks can also be useful in identifying any potential problems at a treatable stage such as dental issues or osteoarthritis which can cause pain and negatively impact the dog's wellbeing.

At the end of the day, it's a combination of our dog's genetics and the environment they live in that impacts their longevity. So while we can't change their genetics, there are many things we can do to improve their health that may just help them live a longer, healthier life.

Jacqueline Boyd, Senior Lecturer in Animal Science, Nottingham Trent University.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Greenland Sharks Live Hundreds of Years; Can These Sharks Teach Humans How to Live Long? – Science Times

Monday, August 30th, 2021

A fishing expedition 15 years ago off the west coast of Greenland led scientists to discover the world's oldest vertebrate, Greenland sharks. This species can live at least 250 years. Scientists see lifestyle and genetics as a possible cause, and gene therapy techniques help humans adopt the same longevity.

Danish marine biologist John Steffensen was on a fishing expedition 15 years ago when he spotted an unusual-looking shark that hung from the boat's edge. Greenland sharks are large, sluggish, and awkwardly proportioned sharks that roam the icy depths of the North Atlantic Ocean and the Gulf of Mexico.

Steffensen and his colleagues published their findings in a study titled "Eye Lens Radiocarbon Reveals Centuries of Longevity in the Greenland Shark(Somniosus microcephalus)," onSciencein 2016. Since then, this cadaverous shark has become a sensation, with scientists worldwide trying to unlock the secret of its longevity, noting that it could show humans how to live long.

(Photo: Wikimedia Commons)Close-up image of a Greenland shark taken at the floe edge of the Admiralty Inlet, Nunavut

According toAtlas Obscura, Greenland sharks were commercially hunted for their oil-rich livers during the first half of the 20th century. However, presently, fishers find them a nuisance since these species feed o valuable halibut. Sometimes, they also get tangled with fishnets that could damage equipment on deck if they could not find a way out.

Steffensen's interest in Greenland sharks peaked when he learned of the extreme longevity of the sharks. They tried scanning the sharks for signs of growth rings but failed and found no evidence of their age.

So, he consulted retired physicist Jan Heinemeier from Denmark's Aarhus University, who gave him the idea of dating eye lenses produced at birth and could be subjected to carbon dating.

The results were astounding, showing that Greenland sharks could live at least 272 years up to 512 years old. In thevideoby Wonder World, they discussed that the oldest Greenland shark was 512 years old found in the North Atlantic, which could also hold the record of being the oldest living vertebrate in the world.

The scientists at first could not believe their findings, questioning whether they have made a mistake or not. Another thing they observed is that older Greenland sharks grow at a slower rate than young ones. The largest they found was 16 feet long, but they could still grow up to 18 feet.

ALSO READ: Two Female Sharks Reproduce Offspring; Recorded as First Case of Asexual Reproduction in Italy

Finding out that there could be sharks swimming in the ocean born during the Renaissance period is extraordinary. Scientists have asked how these creatures could live that long. They believe it might be due to genetics and lifestyle.

According toNBC News, Greenland sharks' longevity might have to do with their extraordinary heart and unique immune systems. The sharks' hearts pump slowly by about one beat per 12 seconds, and they have been beating already for centuries. On the other hand, a human heart beats about once every second and gradually slows down as humans age.

Moreover, DNA sequencing of Greenland sharks shows that genetic mutations in them have given them an immune system that can stop cancer and other infectious diseases.

In the future, scientists hope to transplant the genes to humans to promote long life using gene therapy techniques. However, this technology is in its early years, and more studies are needed to be successful.

RELATED ARTICLE: Godzilla Shark From 300 Million Years Ago Finally Gets New Name, Classified as New Species

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9 Healthy Eating Habits to Live Over A Century, Say Dietitians | Eat This Not That – Eat This, Not That

Monday, August 30th, 2021

You don't have to live in a blue zone to live over a century. "Blue zones" are known to have the densest population of people that live to be over 100located in five different communities around the world. And yet, while these communities are known for being the healthiest and living the longest, the truth is, you don't have to be a community member to reap the same benefits. While genetics do play a role in longevity, setting healthier habits also significantly increases your chances of living long enough to reach that three-digit number.

So what's their secret? If you were to place a microscope on these communities, you would notice that their diets include a variety of real, whole foods. They also focus on eating at the table, sharing meals with others, and regularly moving their bodies.

But what's exactly on their plates? We spoke with a few registered dietitians to look at some of the healthy eating habits that can help you to live over a century, and these tips line up closely with the type of lifestyles lived by those in blue zones. Here are the healthy eating habits you can incorporate into your life today in order to have a happier, healthier tomorrow. Then, be sure to check out our list of The 7 Healthiest Foods to Eat Right Now.

"It is well-known that fruit and vegetables are good for you, but it's important to remember that it's more than just that," says Amy Goodson, MS, RD, CSSD, LD. "Colorful fruits and veggies provide the body with various vitamins, minerals, antioxidants, and plant compounds that help the heart, the gut as well as keep your immune system strong and more! Each color of produce contains a different nutrient package."

RELATED:Get even more healthy eating tips straight to your inbox by signing up for our newsletter!

"While everyone's body and natural genetics are different, fueling your body appropriately is a crucial component if you would like to live over a century," says Ricci-Lee Hotz, MS, RDN at A Taste of Health, LLC and Expert at Testing.com. "Ensuring that you consume a varied diet with a range of different fruits, veggies, lean proteins, whole grain, high fiber carbs, and healthy fat, and balancing them appropriately at each meal and snack is crucial to make sure your body is getting everything it needs to function at its best. In addition, keeping your stress levels down (especially surrounding food) can always help your body stay as healthy as possible, too."

"Following a plant-based diet is one of the best possible dietary choices to live a life with greater quality and quantity," says Trista Best, MPH, RD, LD, and a registered dietitian at Balance One Supplements. "For many who turn to a plant-based diet, their goal is overall health and reduced risk of chronic disease, which culminates in longer life. Among the many benefits of a plant-based diet, including, heart health, weight loss, and diabetes prevention a new secondary benefit is emerging; reduced cancer risk."

Best points out research from the American Institute for Cancer Research which states that one of the best ways to prevent cancer is through dietary means. Focusing on nutrients like fiber, vitamins, minerals, and phytonutrients into your diet is key, and can be found in foods like vegetables, fruit, beans, grains, nuts, and seeds.

If going plant-based does not feel like something that is attainable for you, Best also recommends focusing on a flexitarian approach if you want to live over a century.

"For many, this can be a daunting task and a flexitarian approach may be the best option," she says. "Regardless of where you fall, reducing animal protein in your diet will improve your longevity."

Here are 10 Benefits of Eating a More Plant-Based Diet.

"The healthiest of people fill their plate with nutrient-rich foods like whole grains, fruits, vegetables, lean protein, dairy, and healthy fat, but they also allow for pleasure foods," says Goodson. "The key to a long, happy life is balance. The majority of the time, 80%, eat foods to fuel your body and keep it strong. Then 20% of the time enjoy vacations, holidays, and desserts with the people you love. It's the best plan for the body and the soul."

It's all about setting healthier habits for yourself! Here are5 Healthy Dessert Habits For A Flat Belly.

"It's important to not overeat," Rachel Paul, PhD, RD from CollegeNutritionist.com. "Overeating calories, even of healthier foods, leads to weight gain. Those with overweight or obese bodies are more likely to develop diseases such as diabetes, heart disease, and some cancers, which can lead to premature death."

One of the best ways to combat overeating is to start paying attention to your body's hunger and fullness clues, portioning out your meals, and setting specific times for meals and snacks throughout the day. Overeating and mindless snacking can easily come hand-in-hand, so it's important to set healthy snacking habits that will help you feel full, prevent overeating, and help you ultimately live over a century.

"As we age, we typically lose 2 to 3% muscle mass per decade," says Goodson. "That can lead to falls, bone breaks, and instability as we age. The key? Power up with lean protein at all meals and snacks. Protein helps and builds and repairs muscles helping to keep your body strong as you age. Including foods like lean beef, poultry, fish, eggs, dairy, beans, and legumes can all help you amp up your protein."

"As a dietitian, I'm always telling people to 'eat the rainbow' because all the different colored foods represent different phytonutrients that help keep us healthy as we age," says Mackenzie Burgess, RDN and recipe developer at Cheerful Choices. "One beneficial type of phytonutrient you'll find in colorful fruits, vegetables, and other plant foods are compounds called 'flavonoids.' In fact, recent research has proven these flavonoids to be helping in maintaining our brain health long-term. Flavonoid-rich foods include onions, berries, dark greens, herbs, broccoli, cauliflower, dark chocolate, soy, and citrus fruits."

To easily incorporate flavonoid-rich foods into your diet, Burgess says "For breakfast try mashing together berries and chia seeds to make your own jam. Then, for lunch, blend cauliflower into rice or find it in flatbread form to pair with your favorite protein. Finally, for dinner, try stirring extra onions and herbs into a one-pot curry."

"To keep our brains sharp and to prevent cognitive decline, what we eat can make a difference," says Lisa R. Young, PhD, RDN, author of Finally Full, Finally Slim and a member of our medical expert board. "Foods high in certain vitamins, antioxidants, and phytochemicals may help to boost brain health. Deep red foods such as tomatoes and watermelon contain the antioxidant lycopene which fights free radicals that come with aging. Leafy greens such as kale and spinach are rich in vitamins E and K which may prevent memory loss and help reduce our 'brain age.'"

Related:Why You Need Antioxidants In Your DietAnd How To Eat More Of Them

"As we age, our metabolism tends to slow down so it is important to watch calories and exercise more to avoid weight gain," says Young. "It turns out that maintaining a steady weight and avoiding yo-yo dieting is equally important. The centenarians from Okinawa, known to live long and healthy lives, were known to keep their calories down and their weight steady. Maintaining a healthy body mass index (BMI) has been associated with lower rates of heart disease and certain cancers."

For more, be sure to read our list of The 6 Best Diets That Will Make You Live Longer, Say Dietitians.

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95 and Counting – Arlington Connection

Thursday, June 24th, 2021

95-year-old Howard Eisenberg says he was carded recently and asked to provide proof of his age as he boarded a train on his way to visit his 80-year-old girlfriend.

Three different conductors carded me. I said, Look, isn't my gray hair enough? The conductor said, Nope, that could have started at 40. They insisted on seeing my driver's license and boy, was I proud.

Whats the secret to a long life? Three local seniors reflect on their lives and share their accomplishments and their advice to younger generations.

Born in Manhattan, Eisenberg, who now lives in Alexandria, began his lifelong career as a writer while doing a stint in the military.

I started writing at 18. WWII had just ended and my captain learned that I'd had a couple of years of college. He said, PFC Eisenberg, the Nazis who were in this barracks left a mimeograph machine and a typewriter here. Write me a newspaper to improve morale. You don't say no to your company commander, so I wrote The Rifleman."

Eisenberg, who recently completed the script for a musical, says hes been a writer ever since. I've written for radio and television. Ive written magazine articles, he said. I shared magazine and book bylines with my amazing late wife, Arlene.

To him, age is just a number and he says he has no intention of retiring. There is so much to write about that I don't plan to quit until my fingers break off in the computer keys, he said. And then I'll try dictating.

He has three children, six grandchildren and three great grandchildren. I have to do a bit of math to keep track of progeny, he jokes.

Eisenberg doesnt attribute his longevity to genetics. My mom only reached 62 and my dad his mid-70s, he said. But those were meat-and-potato days. You ate what tasted best, not what was good for you.

Instead, he attributes his good health to prioritizing nutrition and taking vitamins. A healthy diet and regular exercise are two habits that Eisenberg attributes to hitting the 95+ mark. Down with sugar and white flour, he said. The more colorful the food the better.

Broccoli, spinach, asparagus, yams and low-fat, sugar-free ice cream are among the foods that he enjoys. Of course, this is common sense, not prescription, he said.

Inquisitiveness is a trait that Eisenberg advises younger generations to acquire. One of his regrets is not being bold enough to ask questions when he didnt understand something in his youth.

I joined my outfit as an infantry replacement and they gave me a bazooka, which I'd only fired twice and that was in basic training, he said. I didn't remember how to shoot it but was sadly too embarrassed to ask guidance from one of the Battle of the Bulge seasoned veterans. Big mistake.

So when a machine gun nest stopped us and the captain shouted, Bazooka up front, I was momentarily frozen in place, continued Eisenberg. The GI carrying bazooka rockets saved me. He turned and ran to the rear with the ammo and I had to chase and tackle him. By the time I got back with the ammo the machine gun was kaput.

This experience taught him the value of seeking as much information as needed to gain the understanding necessary to complete a task.

You may not carry a bazooka, but there will be many times at different stages in your life when you won't know how to do something. Don't be a shy guy or gal. Ask questions, ask questions, ask questions. Ask until you're sure you understand. Then do it.

Adele Aspinwall Bethesda, 98

Adele Aspinwall was an English teacher in Chicago for 68 years, mostly in the inner city.

"I enjoyed looking out for and encouraging children that some people had written off," she said. "I've had so many students come back to me and tell me how I motivated them and touched their lives. That's how I knew I was born to be a teacher."

When she retired, she moved to Bethesda to be closer to her daughter, three grandchildren and five great grandchildren. Now, 98-year-old Aspinwall lives in the mother-in-laws suite in the home of her daughter.

Aspinwalls mother lived to be 87 years old and her father was 67 when he died. She believes her longevity comes from exercise and a healthy diet.

I would advise young people to begin preserving their health and develop and maintain a sense of style when they're in their 30s, said Aspinwall. Stay current with trends. I dont need to dress like a 25-year-old, but I also dont have to look frumpy. When you look well-dressed then you feel good.

Aspinwall is in a bridge club and plays regularly with a group of friends. She says this helps keep her mind sharp.

Maintain friendships and good relationships with your family members, especially your children, she said. "If thats difficult then set boundaries. But the most important thing is to stay in contact with other people. I dont focus on my age, I just focus on maintaining my health, style and relationships.

Miriam Halprin, 103 of Springfield

Miriam Halprin of Springfield is 103 and credits her longevity to eating and drinking in moderation. You need a positive mental outlook, good genes, a good laugh and an extremely high degree of vanity.

Born in Vermont, she worked as a legal secretary at Hofstra Law School. After retiring at age 75, she moved to be closer to her family which includes one son and one grandson.

These days, she spends her time reading, watching movies and playing cards to keep her mind sharp.

Halprin says her son is her greatest accomplishment, and the life advice that she would give to younger generations is, Always keep a positive outlook and a sense of humor.

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What Lifestyle Decisions Will Help You Become a "Cognitive Super-Ager"? – InsideHook

Thursday, June 24th, 2021

In a recent profile, The New York Times investigates the phenomenon of cognitive super-agers people whose brains remain miraculously youthful even as they join the ranks of centenarians.

For these very few less than 1% of the United States population lives to 100, and cognitive super-agers are a fraction of that their twilight years are not marked by a sudden drop in brainpower. On the contrary, the neurofuction of cognitive super-agers doesnt change much at all after their 70th birthdays. They routinely receive top marks on tests designed to root out declines in understanding, communication, focus or memory.

How is this possible? Researchers are currently studying two methods by which cognitive super-agers are able to ward off the most common form of dementia, Alzheimers disease: via resistance or resilience. With the former, scientists say, some brains are just able to avoid damage. Genetics and lifestyle play a role. But with the latter, fascinatingly, some brains show signs of aging commiserate with Alzheimers and are able to weather the damage regardless. These people, Dr Yaakov Stern tells The New York Times, have a cognitive reserve that enables them to cope better with pathological brain changes.

Of course, longevity isnt appealing to everyone; it isnt uncommon to hear people wishing for an exit in their late seventies or early eighties, the sentiment likely influenced by watching some older relative suffer his or her way into too-old age. But as researchers unlock the secrets of societys healthiest centenarians, and people continue to live longer (the cohort aged 90 and older is Americas fastest-growing population sector), a new kind of promise might begin to perform: live quality years into your hundreds.

No one has the answers yet on how to achieve this. There seem to be some genetic predispositions that help brains that literally start out larger and stronger are less likely to atrophy (the same way a muscle in an arm shrinks due to lack of use or aging). Thickness of the cingulate cortex seems to matter, as does ones prevalence of von Economo neurons.

But both resistance and resilience, researchers believe, can be influenced by lifestyle decisions. There are things you can do right now to stick around longer (and actually have your wits about you while doing so). One of the top recommendations? Enriching experiences. That could mean pursuing higher education, working a job that requires complex problem-solving, or mastering a new craft. Also on the list protecting your hearing and vision (which are closely intertwined with cognitive function), finding a place in a supportive community, making time for leisure and play, eating a Mediterranean-style diet, and exercising regularly.

There are no guarantees here. You may not live to 100 if you do these things, and you may make it there and never remember your own name, but for now, theyre your best shot. The good news? Theyre all things you could look back on after a life lived to only 70 and know you did it right.

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Wentworth weight gains steal the Wagyu show – Queensland Country Life

Thursday, June 24th, 2021

WAGYU F1 steers selected for flat bone and suppleness of hide stole the show in the Wagyu Challenge weight gain phase of the RNA Paddock to Palate competition.

The commercial Wagyu operation Wentworth Cattle Co, owned by Richard and Dyan Hughes and family from Clermont in central Queensland, almost made it a clean sweep of the Wagyu section.

Their best pen of 50 per cent Wagyu cross steers took out first place with an average daily gain of 1.159 kilograms and second place with a gain of 1.097kg. One steer recorded the highest individual weight gain of 1.289kg/day over 360 days for an exit weight of 800kg.

The long-fed Wagyu programs are designed to achieve a consistent lower gain over a long period of time, to enhance the marbling for which the breed is famous.

TOP PERFORMER: The steer from Wentworth which collected the highest individual weight gain of 1.289kg/day over 360 days for an exit weight of 800kg.

Wentworth Cattle Co started with a Brahman cross Red Poll cow base, and currently joins around 8000 F1s through to purebred Wagyu females at Strathablyn near Bowen, and Table Top at Collinsville, managed by Bristow and Ureisha Hughes.

The steers move to Wentworth as weaners where they are backgrounded before being sold to various feedlots at 300 to 480kgs, destined for a number of Wagyu branded products, including Mort & Co's award-winning Phoenix Beef.

Sires of the winning 2021 pen were from Hornery Group's Bar H at River Lea, Comet, Guyra's Door Key Wagyu and Kelva Camm's Cross Bar Wagyu at Clermont.

However, Dyan Hughes explained these steers were chosen while Wentworth was still very much in drought in April 2020 and pedigree was not in the main criteria.

"Flat bone delivers meat tenderness, suppleness in the hide allows for growth and greasiness of spine reflects hormonal activity which delivers flavour," she said.

"The steers were hand-selected for these indicators - good eating quality is the result, but these are also linked to fertility.

"Since the start of time, Wagyu breeders have pursued meat quality and that has also provided exceptional fertility. That also works conversely."

Wentworth uses a Wagyu geneticist to help with bloodline decisions.

"Our daughter Kelva works with Alan Hoey designing mating plans - it's a 'this goes with that' approach to create the ultimate animal," Mrs Hughes said.

"We aim for a balance in frame, marbling and feed conversion in both sexes, combined with fertility, milk and resilience in females.

"We are building longevity into our herd, and making it one that is adapted to the vagaries of northern conditions.

"This is a herd that thrives under regenerative management practices. We like to keep things as natural as we can, hence the move to knock the horns off using polled genetics."

Interestingly, over the 25 years they've been involved with Wagyu breeding the Hughes have used genetics from many of their fellow competitors in this year's competition, including polled Wagyu genetics that became available four years ago.

"Data on the polls is just starting to come through, and it's very promising," Mrs Hughes said.

"Sapphire Feedlot at Goondiwindi achieved a remarkable result with our steers, however F1s often outperform higher-content cattle in weight gains. The real challenge is in the next classes, relating to carcass, carcase dollar value and the ultimate test, the taste-off."

The Hughes family consider it a privilege to compete in competitions like the RNA Paddock to Palate, saying benchmarking against industry leaders and lessons learned are invaluable.

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People on the Move: Appointments, retirements, achievements – Beef Central

Thursday, June 24th, 2021

Beef Central publishes an occasional summary of appointments, departures and achievements occurring across the red meat and livestock supply chain. Send details for entries toadmin@beefcentral.com

Australias Chief Veterinary Officer Dr Mark Schipp has recently completed his three-year term as President of the World Organisation for Animal Health (OIE).

Mark Schipp

Dr Schipp last month represented Australia at the 88th general session (virtual) of the OIE, his last official function as president.

Secretary of the Federal Department of Agriculture, Water and the Environment, Andrew Metcalfe, said Dr Schipps leadership as OIE President had reinforced Australias global influence on a large range of issues related to animal health and welfare. Australias leading role in setting international standards around animal health and welfare has been strengthened by his important work, Mr Metcalfe said.

Dr Schipp said the challenges of the COVID pandemic had highlighted the importance of the work that the OIE does.

It also presents an important opportunity for OIE members to strengthen relationships under the One Health frameworkthe interconnection between humans, animals and our shared environment, he said.

Despite the physical distance that may separate us through our collaborative, approach, we continue to address the many important global issues related to animal health and welfare.

With wildlife the source of many emerging and zoonotic diseases, during Dr Schipps term as OIE President he oversaw the development of a Wildlife Health Framework by the OIE Working Group on Wildlife to create new approaches to wildlife health management.

He also achieved increased OIE member engagement and participation in international standard setting, through strong advocacy and Australian funding for international workshops on implementation of standards related to animal health and welfare.

Under Dr Schipps leadership, the OIE also implemented the OIE Observatory, which is collecting data on the relevance and impact of the OIEs standards to members, allowing this information to support more effective solutions to global animal health and welfare challenges.

As a veterinarian, I am very aware of the need for global animal health and veterinary services to be strong, influential and effective contributors to addressing the global animal health challenges that we face, such as antimicrobial resistance, food insecurity and identification of future pandemics at their source, Dr Schipp said.

The Australian Agricultural Co has promoted David Harris as the companys new chief operating officer, following the recent departure of former COO, Anna Speer.

Ms Speer left AA Co in late April to take up a new role as head of Woolworths new Greenstock red meat supply chain business.

In March 2020, Mr Harris was appointed to the role of AA Cos COO supply chain. Prior to this he was working with AA Co from 2016 in a contracted capacity reporting to the CEO and Board to improve operational aspects of the business.

Since Anna Speers departure, Mr Harris has taken over her previous COO responsibility for Pastoral Operations, as well as his original role as supply chain COO.

Earlier in his career he worked in the lotfeeding sector, holding executive positions with Stanbroke, Smithfield Cattle Co and running his own private agricultural consultancy business and family farming operations in central western New South Wales. He holds a Bachelor of Rural Science from the University of New England specialising in ruminant nutrition and meat science.

In other recent AA Co appointments and promotions, AA Cos experienced pastoral operations manager Michael Johnson has been promoted to the new position of head of pastoral operations.

Previously he managed AA Cos Barkly Group and Brunette Downs station. He originally joined AA Co in 2010 as manager of Avon and Austral Downs, having previously worked with Stanbroke Pastoral Co where he gained extensive experience in the cattle industry, progressing his career from stockman into management roles across a number of enterprises throughout Northern Australia.

He currently sits as an executive of the Northern Territory Cattlemens Association and chairs the Barkly Regional Advisory Council. He will continue to operate out of Brunette Downs.

In other recent AA Co appointments, the new role of head of supply chain operations has been filled by Patrick Vialle, who has had extensive supply chain management experience in the corporate food sector with global giants, Nestle, Retail Food Group and Parmalat.

Mr Vialle, who joined the AA Co business last September before the recent promotion, will oversee supply chain operations, based out of AA Cos Brisbane office.

Meat & Livestock Australia has made a series of recent appointments in middle and upper management roles, both here and in overseas offices.

Scott Cameron has been appointed Group Industry Insights & Strategy Manager, in the Marketing & Insights team.

Scott Cameron

He starts in his new role today, 23 June, following the recent departure of Natalie Isaac. Prior to joining MLA, Mr Cameron already had a depth of experience across marketing, insights and strategy roles in the corporate world, including roles with Nestle, Coca-Cola, and Frucor Suntory.

In his 18 months with MLA, he has been a champion for collaboration across business units and the industry. Working closely with the Insights and International Markets teams, Mr Cameron has contributed to the Category Growth Driver projects for Japan, Korea, and Australia. In addition, he has played a significant role with the Sustainability Discovery Sprint.

He has led strategic engagement with major retailers, with a focus on evolving their approach to Shopper Activation and Category Management, as well as building strong networks amongst brand owners and the processing sector.

Meanwhile, former global industry insights & strategy manager Natalie Isaac finished up with the industry service delivery company yesterday, after five years with MLA. She has accepted a new role with Huon Aquaculture in Tasmania.

Across a range of projects from Data Transformation to the Category Growth Drivers, Ms Isaac connected and engaged effectively with teams including ISC, MSA, Genetics, and Science & Innovation that previously had limited interaction with the marketing & insights team.

She played a key role in the development of MLAs global markets strategy, which then led to the development of market classification. This has been widely used both internally and externally by commercial stakeholders to make better decisions identifying high value growth opportunities.

In other recent MLA appointments:

The man responsible for the smooth operations behind last months hugely successful Beef Australia 2021 event in Rockhampton has moved on.

Beef 2021 CEO Ian Mill

Ian Mill has accepted a position from August, as acting chief executive of the Rockhampton Jockey Club, an organisation he has served as a board member for since 2018. Mr Mill led a team of 80 staff and more than 200 volunteers to deliver Beef 2021, which attracted 115,866 people across the week-long internationally recognised beef industry exposition.

Horse racing has been a passion of mine for a long time, both as a volunteer on the local board, as well as having shares in racehorses albeit on somewhat of a social scale, Mr Mill said.

The Thoroughbred industry has always been something I have followed keenly, so when the opportunity arose to step into this role, and with my contract at Beef Australia coming to an end, I jumped at the chance.

Beef Australia board chairman Bryce Camm acknowledged his contribution.

We greatly appreciate Ians contribution to Beef 2021 which despite the challenges and unknowns associated with Covid has been hailed an overwhelming success by all, from our tens of thousands of visitors and participants through to our stakeholders, Mr Camm said. Many of Ians management skills and abilities displayed in delivering Beef 2021 will serve him and the Rockhampton Jockey Club well in his new role. We thank Ian for his service and wish him continued success in serving the Rockhampton community which he is so passionate about.

After spending the past three years working as Chief Scientist on secondment from the University of New England, the Food Agility CRC has announce that Professor David Lamb will now join the CRC full time.

In addition to continuing his role as Chief Scientist overseeing research across the entire program of CRC activities, Professor Lamb will be heading the Food Agility CRCs newGlobal Digital Farminitiative. He continues his ongoing contribution to academia, through both research and teaching, as an Adjunct Professor of UNE.

Specialist rural property agency JLL has appointed Jock Grimshaw to join JLLs Agribusiness team based in Melbourne.

Jock Grimshaw

Formerly working with Colliers International, he will report to JLLs Director of Agribusiness, Clayton Smith, and will focus on campaigns across southern markets including Victoria, New South Wales and South Australia.

Following the boom in the Australian rural market, JLL had recorded more than $160 million in sales for the first quarter of 2021, the company said in a statement supporting Mr Grimshaws appointment.

Jocks experience and reputation in the marketplace will provide us with access to a broad cross-section of clients and asset types, and his knowledge will greatly benefit our clients, Clayton Smith said.

The Australian agribusiness market continues to assert its position as a secure and stable asset class. The market is currently the strongest it has been in ten years, and sales activity is not predicted to slow as family, private, institutional and non-traditional buyers look to the rural sector for investment longevity and stability.

Growing our Agribusiness team is a clear indicator of the strength of this sector and shows the confidence we have in strengthening our service offering in southern markets as Melbourne recovers from the COVID-19 pandemic, Mr Smith said.

Experienced bull breeder Ian Durkin has been elected chairman of the Herefords Australia board.

In line with past practice, all Herefords Australia board positions are declared open in the first board meeting after the breed societys annual general meeting.

Both Trish Worth and Ian Durkin were nominated for the position of chairman, with Ian Durkin duly elected by HAL directors.

Mr Durkin was first elected to the board in May 2020 and held the position of member liaison representative. He owns and manages a mixed farming operation near Coolatai with his wife Shelley and three children.

The position of chairman is an important one, but I believe it is the combination of the diverse skills and experience of all directors that makes for an effective board, he said. I will be drawing on this team to ensure we have sound policies in place to support the advancement of the breed and good governance in place to strengthen the company.

I also understand members want to better understand the strategic direction for the breed. I look forward to the development of the next plan and the role the board plays in monitoring progress and reporting to members outcomes of our investments and activities.

Mr Durkin replaces Trish Worth, who served as chair for the past 12 months. Ms Worth continues her tenure as Herefords Australia director and has been appointed to the finance, audit and risk committee. In other HAL board appointments, Geoff Birchnell was elected as member liaison representative and Michael Crowley elected to the marketing committee.

The 2021 Herefords Australia Board comprises Ian Durkin (chair), Marc Greening (deputy chair), Mark Baker (company secretary), Sam Becker, Geoff Birchnell, Michael Crowley, Ian Durkin, Mark Duthie, Alex Sparkes, Trish Worth.

Smarter farming systems that thrive through drought are among the agricultural innovations recognised at the annual awards of the Australian Academy of Technology and Engineering (ATSE).

ATSEs prestigious annual ICM Agrifood Award is bestowed on applied scientists who have made significant contributions to the agriculture sector.

One of the 2021 winners was Dr Lindsay Bell, Farming Systems Scientist at CSIRO, for world-leading research helping dryland crop and livestock farmers manage climate variability.

Dr Bells research focuses on redesigning cropping systems and re-integrating crops and livestock to more efficiently use highly variable rainfall to increase profitability and reduce losses during droughts. He has been instrumental in developing dual-purpose canola that works both as a crop and a feedstock, and designing protocols to help farmers graze their crops at a time that reduces the risk of grain yield losses.

Growing up on a farm in western Queensland I have firsthand experience with many of the challenges facing agriculture, Dr Bell said.

This has driven me to try to identify practices, technology and markets that help farmers become more viable in the short and long term.

ATSE President Professor Hugh Bradlow congratulated the winners, saying the ICM Agrifood Awards recognise the vital role of R&D in advancing Australias strength as an agricultural powerhouse.

The Graham Centre for Agricultural Innovation has celebrated the achievements of PhD graduates during formal ceremonies at Charles Sturt University recently.

The graduates from the Centre, an alliance between Charles Sturt and the NSW Department of Primary Industries, were among the 600 graduates who attended the Universitys ceremonies in Wagga Wagga, which were postponed last year due to COVID-19.

Dr Cara Wilson and Dr Thomas Williams celebrate graduation at Charles Sturt University.

Charles Sturt University PhD graduate Dr Cara Wilsons PhD research through the Graham Centre examined the impact of hydatid disease on the beef industry in eastern Australia. As part of her research, Dr Wilson examined data from 1.1 million cattle slaughtered at a focus abattoir from 2010 to 2018.

She found the geographic distribution of hydatid-infected cattle was wider than previously thought, with losses to the abattoir from 2011 to 2017 of more than $650,000 in downgraded carcases.

Hydatid disease in beef cattle has important epidemiological and economic impacts on the Australian beef industry, she said. Improved knowledge and awareness of hydatid disease among Australian beef producers is required, and practical and cost-effective control measures need to be identified.

Dr Sajid Latifs research has given new insight on how annual pasture legumes can be used to suppress weeds in south eastern Australian farming systems.

His research examined legumes species such as biserrula, serradella, gland, bladder and arrow-leaf clover established as monocultures and as mixed stands.

Looking at both the above-ground competitive traits and the chemical interactions in the soil rhizosphere Dr Latif looked at the suppression of common annual weeds. He found the choice of pasture species impacted stand establishment, yearly regeneration and weed suppression in pastures, with arrow-leaf clover and biserrula suppressing annual weeds effectively.

Biomass accumulation in pasture species was found to contribute significantly to the reduction of weed biomass for the majority of species followed by light interception at the base of the canopy, Dr Latif said. The results also suggest that plant produced chemical interference is one of the key mechanisms of weed suppression in some of those species, including biserrula and serradella, he said.

Dr Jane Kelly has been awarded her PhD for research examining the prevalence, management and economic impact of seed contamination in sheep carcasses by barley grass.

The findings show the value of proactive and accurately timed integrated weed management strategies for influencing legume pasture composition, reducing barley grass populations and mitigating losses associated with seed contamination in grazing sheep in southern Australia.

Dr Thomas Williams PhD was focused on gastrointestinal nematodes in water buffalo, comparing production systems in Australia and Pakistan.

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People on the Move: Appointments, retirements, achievements - Beef Central

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Pandemic Lessons in Improving the Medical System – The New York Times

Sunday, February 14th, 2021

One of the most dramatic examples was the abrupt substitution of telemedicine for in-person visits to the doctors office. Although telemedicine technology is decades old, the pandemic demonstrated how convenient and effective it can be for many routine medical problems, Dr. Navathe said.

Feb. 14, 2021, 6:09 p.m. ET

Telemedicine is more efficient and often just as effective as an office visit. It saves time and effort for patients, especially those with limited mobility or who live in remote places. It lowers administrative costs for doctors and leaves more room in office schedules for patients whose care requires in-person visits.

Even more important, the pandemic could force a reckoning with the environmental and behavioral issues that result increasingly in prominent health risks in this country. We need to stop blaming genetics for every ailment and focus more on preventable causes of poor health like a bad diet and inactivity.

Consider, for example, the health status of those who have been most vulnerable to sickness and death from Covid-19. Aside from advanced age, about which we can do nothing, its been people with conditions that are often largely preventable: obesity, Type 2 diabetes, high blood pressure, coronary artery disease and smoking. Yet most physicians are unable to influence the behaviors that foster these health-robbing conditions.

Many people need help to make better choices for themselves, Dr. Navathe said. But the professionals who could be most helpful, like dietitians, physical trainers and behavioral counselors, are rarely covered by health insurance. The time is long overdue for Medicare and Medicaid, along with private insurers, to broaden their coverage, which can save both health and money in the long run.

Policy wonks should also pay more attention to widespread environmental risks to health. Too many Americans live in areas where healthful food is limited and prohibitively expensive and where the built environment offers little or no opportunity to exercise safely.

Individuals, too, have a role to play. The pandemic has fostered an opportunity for patients to take on a more active role in their care, Dr. Shrank said in an interview.

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Pandemic Lessons in Improving the Medical System - The New York Times

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The Role of Hormones in Immunocompetence – Anti Aging News

Sunday, February 14th, 2021

The growing importance of hormonal health is becoming an integral component of modern medicine especially as the focus shifts toward maintaining and boosting immunocompetence in the population. Many plausible benefits of hormonal factors on autoimmunity have received growing attention in recent years from the scientific community. Research has been conducted investigating the relationship between immune system function and sex hormones testosterone and estrogen.

Importantly, the immune systems of men and women are known to function differently with 80% of autoimmune diseases occurring in women who tend to show stronger immune responses than their male counterparts. Stronger immune responses in women produce faster pathogen clearance and improved vaccine responsiveness while also contributing to their increased susceptibility to inflammatory and autoimmune diseases.

Results from previous experimental studies have revealed that testosterone can have a medium-sized immunosuppressive effect on immune function, however, the impact of estrogen can vary depending on the immune marker measured. Such differences in immune function and responses have contributed to health- and life-span disparities between sexes yet the role of hormones in immune system aging remains to be understood.

Immune Differences and Dimorphism

The differences in immunocompetency between male and female patients are associated with varying testosterone and estrogen levels major regulators of the immune system. Differences in gene expression between the sexes contribute to the concept of immune dimorphism though they are limited to one or a few types of immune cells. Furthermore, genomic differences between sexes have been found to become more prominent after the age of 65 with men having a higher innate and pro-inflammatory activity along with lower adaptive activity.

Female and males have different energy and nutrient requirements largely based on interactions between external factors and sex hormones; interactions between hormones and a patients environment, including cigarette smoke and viral infections, can lead to variable responses in both genders. While enhanced immunity has been reported in female patients, making them less susceptible to viral infections, their hyper immune response can predispose them to immune-pathogenic effects. In addition, sex hormones can control the immune response via circadian rhythms and their ability to regulate T-cell mediated inflammation.

Microbial Composition

Emerging evidence also indicates that sex hormones can impact the guts microbial composition and thus, impact immunocompetency. Studies have shown that diet-based effects on the microbiome are more prominent in men than in women implicating that dietary interventions may have an influence on sex-based immune responses.

The gut microbiota landscape can impact the systemic levels of testosterone, changing metabolic profiles which may heighten the risk for chronic disease including diabetes. However, current knowledge of the mechanism by which microbiome-derived sex steroids impact immunity remains limited.

Previous research has shown that hormonal contraceptives can increase bacterial species, highlighting sex-hormone-dependent differences and their effects on systemic immune responses. However, the gut microbial composition can be influenced by a variety of factors outside of hormonal levels, such as genetics and dietary habits.

The mechanism underlying sex hormone expression and immunocompetency continues to be investigated; this may result in the improvement of future designs for targeted therapeutics that mitigate sex hormone-inflammatory activity or autoimmune diseases. Clinicians interested in expanding their knowledge on the role of hormones in immune function and longevity are invited to attend the cutting-edge, interactive online Role of Hormones in Immunocompetency and Longevity workshop taking place on February 20, 2021.

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The Role of Hormones in Immunocompetence - Anti Aging News

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