StemCell Therapy

This transmission electron microscope image shows SARS-CoV-2-also known as 2019-nCoV, the virus that ... [+] causes COVID-19-isolated from a patient in the U.S. Virus particles are shown emerging from the surface of cells cultured in the lab. The spikes on the outer edge of the virus particles give coronaviruses their name, crown-like. (Photo by: IMAGE POINT FR - LPN/BSIP/Universal Images Group via Getty Images)

When we get sick we trust our immune system to protect us, but what happens when that system goes awry and ends up killing patients? COVID-19 is shedding new light on how viruses can kick some patients immune system into overdrive to deadly effect in what is known as a cytokine storm syndrome.

In short, our immune system by and large is incredibly effective at working around the clock to keep a myriad of infections and diseases at bay while simultaneously being able to identify between outside invaders and our own cells and effectively prioritise what to attack and what to protect. However, occasionally, either due to genetic factors or rampant viral infections like COVID-19, our immune system can become overzealous and go rogue - attacking and killing everything in sight, including healthy cells in the body. When that happens it is referred to as a cytokine storm and it may be killing around half of severe COVID-19 patients.

Cytokines are inflammatory immunologic proteins that are there to fight off infections and ward off cancers, says Randy Cron, M.D., Ph.D, at theUniversity of Alabama at Birmingham, But when they are out of control, they can make you very ill.

It is important to note that many things have to happen before a potential COVID-19 related cytokine storm is triggered, which is why the majority of COVID-19 patients will never have to deal with the syndrome. According to the Centers for Disease Control (CDC), This first preliminary description of outcomes among patients with COVID-19 in the United States indicates that fatality was highest in persons aged:

Which means that odds are if you contract COVID-19 you will be able to ride it out at home. You can thank the immune system for that because it does not just have one means for defending you against disease, but many many tools in its tool belt to keep you alive.

Dr. Randy Cron, of the University of Alabama, is a leading researcher of cytokine storm syndrome. He explains The data out of China, as well as elsewhere, suggests that about 80% of patients can ride COVID-19 out at home because they are either asymptomatic or feel like their having something like a horrible case of the flu. Continuing, However, about 20% require hospitalization and of those 20% that are being hospitalized, it's entirely unknown what percentage have a cytokine storm so it makes it hard to gauge the mortality of COVID-19 related cytokine storms.

Dr. Cron goes on to explain that the typical mortality rates in adults who develop the syndrome ranges from 50% to 80%. Until further research is done to track COVID-19 related cytokine storm indicating symptoms along with positive cytokine indicating tests we will not yet know just how prevalent cytokine storms are in COVID-19 patients.

Our immune systems are far from simple and have a number of safe guards to keep invaders out. This can be broken down into our innate immune system and our active immune system, which is contributes to our adaptive immune response, as well as our passive immune system, which is "borrowed" from another source and lasts for a short time (for example, antibodies in a mother's breast milk give a baby temporary immunity to diseases the mother has been exposed to).

Put (very) simply, the innate immune system response relies on the use of physical barriers like our skin and mucous membranes, coupled with our first responder defenders like phagocytes, antimicrobial proteins, and attack cells. The innate immune system response is why, for example, we get a stuffy nose and sneeze when we have a cold, or why a scrapped knee gets red, hot and inflamed, as well as sometimes filled with pus. By and large, this first defense is effective and may be why many people who contract COVID-19 are asymptomatic.

However, when the innate immune system isnt enough it calls on our second line of defense; the active immune system. This is typically when the inflammatory response gets kicked into higher gear and you develop a fever, which triggers a number of your bodys chemical alarms that call the active immune system to action and increases the metabolic rates in cells, thus allowing them to heal faster, as well as making it easier for a variety of immune response cells and proteins to do their jobs faster and more effectively. This is also when people start feeling body aches associated with COVID-19 and other viral infections.

The active immune response is both complex and elegant and (again put very simply) not only identifies and fights off viruses like COVID-19, it also remembers these viruses so it can quickly and effectively combat and neutralize them in the future, thus creating immunity. This is why vaccines are one of the more amazing developments of modern medicine. So if all goes well (or relatively well), then our immune system will protect us and we will live to tell the tale, but what happens when things start going awry?

Viruses like COVID-19 have a devious trick up their sleeve when it comes to making us sick; in a sense, they use human cells to shelter and reproduce. When COVID-19 is searching the body for a cellular host to attach to it is fairly exposed and it is easier for our active immune response to target and kill them. COVID-19 wants to do three things when it enters our body; find protection, reproduce and spread. Our cells offer the perfect environment for COVID-19 to do all three. So COVID-19, which targets the respiratory system, attaches and infiltrates our respiratory cells where it can more effectively hide from our immune system early on and reproduce. The infected cell will then spit out more of the COVID-19 virus that will repeat the process. This is where the battle royale of our immune response kicks off with our cellular immune response.

Yet again put very simply, our body has a special cell called the T-Cell, which has a variety of forms that it exists in to combat infection. When T-Cells are activated they release cytokines (yes, that cytokine), which trigger additional T-Cells to be made, which then release even more cytokines. One type of T-cells that are created are called cytotoxic T-cells. Cytotoxic T-cells are the cells that are able to roam the body and mercy kill infected cells who are chemically calling out to be killed and ideally to stop the increased production of viruses like COVID-19.

When your body responds the way it is supposed to, the cytotoxic T-cells will only target infected cells to be killed and move along. Additionally, the immune response also has a chemical indicator that ideally tells overzealous immune response cells to stand down once the threat has been neutralized. It is when we are in the throes of a cytokine storm that those systems start to get overwhelmed and malfunction. In essence, our bodys immune response gets so amped up that it stops differentiating between infected and healthy cells and attacks everything in its path. For obvious reasons, this is very bad for patients because not only is the COVID-19 virus killing the cells in our bodies, now our immune system is too.

Dr. Randy Cron and his colleagues began recognizing instances of cytokine storm syndrome in the early Chinese reports of COVID-19. The way we are seeing cytokine storms manifest in COVID-19 patients are that we are typically seeing a fever and some degree of respiratory distress. He says, However, we are also seeing patients who look like they're in septic shock and become hypotensive as they get sicker. He explains that many COVID-19 patients also have bleeding or clotting abnormalities as well saying, COVID-19 seems to have a really high propensity to lead to clots either in deep veins or in the brain or in the lungs, for example.

Cat Scan. Pneumocystosis In Right Lung. Pneumocystis Carinii Interstitial Pneumonia. (Photo By ... [+] BSIP/UIG Via Getty Images)

However, most notably, COVID-19 patients are most often dying of acute respiratory distress syndrome (ARDS), which indicates that COVID-19 related cytokine storms, like the virus, are focused in the lower lung. This leads to the instances of acute pneumonia and the need for intubation and ventilator use. It also means that patients are dying of cytokine storms faster in instances of COVID-19 than other infections.Most cytokine storm related deaths happen as a result of multi-organ failure, which is why it has such a high mortality rate. Says Dr. Cron, However, with COVID-19 we are seeing people die from pulmonary complications typically before the multi-organ failure can set in. It may just be that patients are getting so sick with their lungs that they're already deathly ill before the rest of the syndrome develops. No one really knows.

Our understanding of cytokine storms is relatively young within the medical field and most of the literature around the syndrome did not take off until the 1990s. There are a lot of people who, both in the lay community and the medical community (particularly if they were trained a longer time ago), that are unfamiliar with cytokine storm syndrome. says Dr. Cron, This syndrome occurs unfortunately every day in ICUs, both in pediatrics and adults across the planet, as a result of a whole variety of conditions that go under-diagnosed and therefore under-treated. However, COVID-19 is changing that.

Luckily, the tests to diagnose cytokine storms are often cheap and readily available in hospitals. Dr. Cron explains that when patients are in throes of a cytokine storm, You will notice an elevation in the serum ferritin, a protein in the blood. Usually the value is less than 200 nanograms per ML and for COVID-19 related cytokine storms, it tends to run between 500 to the low thousands. The test to measure serum ferritin is cheap, readily available in most hospitals, and has a fast turn-around time. If a patients serum ferritin results are elevated, then it is a good early indicator that further testing is needed.

A complete blood count or CBC is a really common standard test. says Dr. Cron, And COVID-19 patients, for whatever reason, seem to be very lymphopenic, meaning their lymphocyte count tends to be less than a thousand per microliter. Continuing that, We don't know if it's more of a cytokine storm feature or just the virus itself, but it certainly suggests that you're not going to do well.

Cytokine storms also can be indicated by liver enzyme abnormalities. The liver gets very unhappy with the cytokine storms and as a result liver enzymes will go up, says Dr Cron, We see also an increase in a protein called D dimers and lactate dehydrogenase (LDH) levels also tend to go up as well. So luckily, despite the relative youth of the field, there are relatively straightforward indicators to diagnose and therefore treat cytokine storms.

There are also a few effective treatments for cytokine storms despite the fact that we still do not know exactly which treatments will ultimately be developed and recommended across the board for COVID-19 related cytokine storms. There's always kind of this push pull between doing no harm and trying therapies that haven't been tried for this disease because it's new to mankind. says Dr. Cron, It's hard to watch people dying in front of you so if you can intervene in some way to help stop that, then that's what doctors are going to do and why some of our colleagues are trying to treat COVID-19 related cytokine storms with just any approach that seems reasonable based on how theyve treated other cytokines storms in the past.

A chemist displays hydroxychloroquine tablets in Kolkata,India on April 10,2020. Amidst concerns ... [+] over domestic shortage, India has lifted the ban on some drug exports including hydroxychloroquine. (Photo by Debajyoti Chakraborty/NurPhoto via Getty Images)

Among other therapies, a few that have recently gotten attention (controversially or otherwise) are hydroxychloroquine and a drug called Actemra. While hydroxychloroquine has been touted by President Trump repeatedly, hospitals have reported mixed results. As Forbes contributor, Anita Bartholomew explains, One of the mostdramatic press reports of apparent successcame from a skilled nursing facility for veterans in Lebanon, Oregon. A doctor treated eight elderly veterans with a combination of hydroxychloroquine and azithromycin (an antibiotic thats been used in tandem with the anti-malarial, and in a French study, showed better results than hydroxychloroquine alone). One died, but the others recovered, including a 103-year old who was seriously declining prior to getting the medication, and survived to celebrate his 104thbirthday on April 1, 2020.

Actemra is a drug that was designed to treat rheumatoid arthritis, but was also approved in 2017 to treat cytokine storms in cancer patients. Actemra was recently successfully used to save a Seattle emergency room doctor who was near death after he contracted COVID-19.

Additionally, There are both broadly immunosuppressive approaches, such as high-dose corticosteroids, and more novel targeted approaches that go after inflammatory cytokine proteins, Dr. Cron said in a Q&A, While we are attempting to develop vaccines for COVID-19 and are trialing novel or re-purposed anti-viral therapies for COVID-19, let us also not forget to treat the patient with all we have to offer to help save lives. We need to address the immediate needs for the significant numbers of patients becoming critically ill in the current pandemic.

While cytokine storms are admittedly terrifying, there is still some hope for COVID-19 patients who develop the syndrome. Now that physicians are more aware of the syndrome and how to identify and treat it we are on track to develop more effective therapies and fail safes that can save more and more patients as the COVID-19 pandemic develops and (eventually) subsides.

Full coverage and live updates on the Coronavirus

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What Is The Cytokine Storm And Why Is It So Deadly For COVID-19 Patients? - Forbes

PALM BEACH, Fla.--(BUSINESS WIRE)--Stress is a part of life for many of us especially now more than ever. Whether we are having trouble adjusting to working from home, caring for a sick relative or home-schooling children, it seems everyone is experiencing some form of stress during this global health crisis. However, science tells us that extreme amounts of stress and sleeplessness can suppress our immune system and make us more vulnerable to illnesses.

Its well established, scientifically, that chronic stress and sleeplessness can significantly blunt the immune system. Right now, Americans are experiencing extraordinary stress at a time when compromised immunity can be devastating, said Dr. Richard Cartledge, Chief of Cardiovascular Surgery at Boca Raton Regional Hospital and inventor of Xen by Neuvana. One of the most remarkable ways known to combat your bodys stress response is through electronic vagus nerve stimulation. We created Xen by Neuvana to make this previously inaccessible technology available to everyone.

People are feeling the effects of stress more than ever

Chronic stress, worry, and lack of sleep negatively impact our immune system, throwing it off balance and increasing the risk for development or worsening of diseases. In these challenging times, people are experiencing new stressors from job security to taking care of children out of school and adjusting to working from home. In a recent survey by Neuvana, more than half (51%) of Americans said working from home adds to their feelings of stress.

Isolation can take its toll, as well. Social interaction may indirectly strengthen immunity, as friends typically help with encouragement of healthy behaviors and help buffer the stress of negative events. Studies have shown that individuals who are socially isolated are approximately 2-2.5 times more likely to have clinically high levels of C-reactive protein, which measures inflammation as a sign of stress in the body, as opposed to those who are socially well integrated.

The chronic stress we are experiencing these days can have many short- and long-term effects suppressing immunity, decreasing the number of immune cells and increasing the number of immunosuppressive cells. In the short and medium term, it can create social anxiety, sensitivity to pain, disrupted sleep, chronic pain, depressed mood and social withdrawal. And in the long term, individuals under chronic stress are more likely to experience susceptibility to infection, inflammatory diseases, accelerated aging and early mortality. Cortisol, the bodys primary stress hormone, is produced in abnormally high amounts during chronic stress, which can depress the immune system.

Managing stress and getting enough sleep can help us to fight off illness, to lower the risk of diseases and may even help enhance our response to vaccinations. One way to help boost your immune system, right now, at home, is through vagus nerve stimulation (VNS).

What is Vagus Nerve Stimulation (VNS)?

Your brain and body are designed to self soothe during or after stressful moments. Your parasympathetic nervous system kicks in to balance the stress response and promote relaxation by slowing your heart rate and breathing and the vagus nerve plays a key role in coordinating this response. While stimulation of the vagus nerve has become a more common topic in recent years, humans have practiced forms of vagus nerve stimulation for centuries through meditation, yoga, mindfulness and deep breathing exercises. When toned or strengthened just like a muscle, the functions of the vagus nerve can be amplified bringing on feelings of calm, boosted mood and better sleep.

Neuvana brings the benefits of VNS home

Neuvana a team of physicians, expert engineers and wellness practitioners has found a way to bring the calming effects of VNS through Xen a new wellness device that safely and gently tones the vagus nerve for better sleep and reduced stress and anxiety.

Xen by Neuvana works by sending a gentle, calming electrical signal via patented earbuds to the part of the vagus nerve located in the ear. This promotes relaxation during any activity - even while social distancing - like working from home, after a yoga session, reading a book to the kids before bed, or listening to music. Regular use delivers maximum benefits, often with just two 15-20-minute sessions a day.

In light of Aprils Stress Awareness Month and this global health crisis, the team at Neuvana want to make VNS more accessible and are offering the Xen Box Set for $329, a $70 discount off MSRP through May 15, 2020. Additionally, for every unit sold, Neuvana will donate $20 to Feeding Americas COVID-19 Response Fund. For more promotional information, and other stress relieving and wellness tips, please visit http://www.neuvanalife.com.

Xen by Neuvana is available for order today with an optional monthly premium app fee of $3.99. All users will receive a 60-day free trial of the premium app, which includes additional waveforms and signals. Neuvana offers a 30-day money-back guarantee if not fully satisfied.

Media members interested in more information or executive interviews may contact Neuvana@maxborgesagency.com. Press kit can be found here. Detailed feature and tech spec list can be found here.

This product is for healthy users interested in potentially improving their general wellness. Individual results may vary. Neuvana offers a 30-day money-back guarantee if not fully satisfied.

About Neuvana LLC.

Neuvana is a South Florida-based brand at the intersection of wellness and technology, continually striving to improve peoples lives through accessible Neuroscience. Founded in 2014 by Dr. Richard Cartledge, an avid inventor and Chief of Cardiovascular Surgery at Boca Raton Regional Hospital, the company is made up of physicians, intellectual property experts, engineers, experienced business professionals and a world-class scientific advisory board with a shared goal: a platform to make the wellness benefits of neuroscience safe, easy and accessible to everyone.

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Lack of Sleep and Chronic Stress Hurt the Immune System: Here's How Vagus Nerve Stimulation Can Help During a Global Pandemic - Business Wire

Most of us actually already know how we can strengthen our immune system, by simply eating foods that are high in nutrients, getting regular movement and exercise, getting enough vitamins, and so on. We are living in a very toxic world and we need to protect ourselves and eliminate any disease by taking better care of ourselves. Sometimes it takes an extreme situation like we have right now to make us more aware of our health.

Viruses and bacteria are two types of potentially disease-causing (pathogenic) particles. Viruses are much smaller than bacteria and can be transmitted in a variety of ways. Coronaviruses are a group of viruses that usually cause mild illnesses, such as the common cold. However, certain types can infect the lower airway, causing serious illnesses like pneumonia or bronchitis. Most people will get infected with a coronavirus at some point in their lives and the majority of these infections are harmless.

There are countless things that can weaken our immune systems and prevent our bodies from fighting off viruses. For example, being sedentary, consuming a lot of added sugar (such as in baked goods or sodas), being overweight, having type 2 diabetes or an existing disease such as heart or lung and respiratory conditions, autoimmune disorders, and issues related to gut health and nutrient deficiencies, especially protein, zinc, vitamin A and and vitamin D. All these high risks can weaken our immune system, as well as countless others including smoking, stress, and insomnia. In other words, a lot of people can suffer from a weakened immune system.

So how can we strengthen it?

Lets start first with exercise. Even without going to the gym, just being active during the day will help you boost your immune system. If youre able to get outside then, for example, simply going for a walk, maybe a 15 minute walk twice a day or a 30 minute brisk walk can have a very positive effect. If the current situation is preventing you from going outside then even in your home you can get some good exercise. You really dont need equipment, your own body weight is more than enough. You can also be creative and instead of weights and gym equipment you can use things like water bottles, bags of cat foods, a chair, a cushion etc. Start looking at your home as if it was a fitness center and you will be surprised what you can do!

The second major factor is our added sugar intake. I have talked a lot about this in my previous articles as sugar is one of the most important factors that can affect our immune system by damaging the gut. And in addition, of course, overconsumption of added sugar, over long periods of time, is associated with being overweight or obese which are risk factors for a wide range of health problems. But even if you are not overweight, excessive sugar consumption has been linked to chronic diseases including type 2 diabetes, heart disease and liver disease. Sugar is a simple carbohydrate (monosaccharide) and also comes in many different forms including glucose (which occurs naturally in fruits and plant juices), fructose (which occurs naturally in fruits, some root vegetables, cane sugar and honey), and galactose (which combines with glucose to form lactose). For example, eating a whole apple versus drinking apple juice will have two very different effects on the body (yes, eating the whole apple is definitely better!).

Other major factors include insomnia and stress, which are both equally important and really can not be separated from each other. When you are in high stress you will be restless and can often not sleep well either. On the other hand, if you have insomnia then eventually you will have stress by increasing cortisol levels, which is a stress hormone. When we stress the body we suppress the immune system because the body thinks that its the time to be alert, and not the time to repair and heal ourselves. When we are not getting enough rest or sleep, we can not repair our body to help keep it in balance or homeostasis.

What about nutrient deficiencies? Proteins are the building blocks that help our bodies repair. Protein deficiencies tend to be hidden for so many people, you may be thinking that you are getting enough protein but bioavailability (such as over-cooked plant based protein) or any digestion problems can impair the absorption. Finding yourself feeling tired often, or losing your hair, can be a sign of protein deficiency.

Zinc deficiencies are common, and zinc is necessary to build our bodys defenses, so a deficiency can increase the risk of infectious diseases. Also, zinc is necessary for the production of the hormone thymulin, which is important for the maintenance of various immune functions. Eggs, meat, shellfish and seeds are excellent sources of zinc.

Vitamin D, the sunshine vitamin or hormone, has well documented benefits, such as improving our bodys defenses, enhancing vitamin A, improving gut microbiota, reducing systemic inflammation, improving mood and sleep, improving muscle strength and reducing respiratory infection. So make sure that you are getting enough sunlight, and in addition you may need vitamin D supplementation. Beef liver, fatty fish, egg yolks and cheese, and of course sunshine, are good sources of vitamin D.

Vitamin A is crucial for maintaining vision and promoting growth and development, and is also known as an anti-inflammatory vitamin because it plays an important role in enhancing immune function. You can find it in foods such as beef liver, salmon, sweet potatoes and carrots.

And selenium is another important nutrient that we should not forget. It is a potent nutritional antioxidant and strongly influences inflammation and immune responses. Brazil nuts, sardines, tuna and shrimp are high in selenium.

The bottom line is that we can not control what is coming from outside, although we still can have an enormous control of our health by taking care of our body and our mind. Dont forget, taking action and preventing yourself from getting a disease or illness is so much better than waiting until you have something before you take action. We should all act now and change our lifestyle for better health.

Resources:

https://www.nhs.uk/conditions/coronavirus-covid-19/

https://www.medicinenet.com/viral_infections_pictures_slideshow/article.htm

https://www.sciencedirect.com/topics/immunology-and-microbiology/rna-viruses

https://www.ncbi.nlm.nih.gov/pubmed/16877062

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763971/

http://sugarscience.ucsf.edu/

https://www.webmd.com/cold-and-flu/cold-guide/10-immune-system-busters-boosters#1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1379072/

https://www.health.harvard.edu/staying-healthy/how-to-boost-your-immune-system

https://www.apa.org/research/action/immune

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162863/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759054/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723386/

https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/

Ayda Ersoy, Nutritionist (Dip.C.N., Dip.S.N.), Master Trainer (CPT ACE, NCSF, CanfitPro), Registered Yoga Teacher, Founder, Health Angel Nutrition, Fitness and Wellness, Founder, SMS (Stability, Mobility Strength) Intuitive Training System.

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What could weaken your immune system, and how to strengthen it - Thegardenisland.com

As the daughter of an air force officer and a nurse, I am fascinated by defence systems. There is none more impressive than the human immune system, equipped as it is with a rich arsenal to defend against different types of pathogen. Viruses have evolved to trick, bypass and evade these defences. Our immune systems have, in turn, learned to recognise and deter these virus stealth tactics. In Covid-19, the enemy is a tiny piece of genetic material wearing a lipid coat and a protein crown.

So how is our immune system able to defend against viral infections, and how does this apply to Covid-19? The virus that causes Covid-19 is called severe acute respiratory syndrome coronavirus 2 (Sars-Cov-2), and was first detected in humans around five months ago. It is a coronavirus. Corona, in Latin, means crown. The virus is adorned with an outer layer of protein covered in spikes, like a crown. These spikes help the virus attach itself to target cells. The research community is fast learning about immunity to Covid-19, and we are also applying our knowledge of similar respiratory viruses to predict what to expect in this infection.

Importantly, Covid-19 cannot gain entry to our homes or bodies by itself we have to let it in

Think of a virus as a robot; it cannot reproduce so it needs a factory of materials proteins, lipids and nucleotides to build copies of itself. The coat allows the virus to attach itself to the target cells membrane. The virus then fuses with the cell and releases a shopping list of instructions on how to build and assemble new viruses. This shopping list, the virus genome, is written in nucleotides (RNA). The first job of a virus that enters our bodies is to invade target cells so that it can comfortably remove its coat and deploy its RNA.

Once inside, the virus commandeers the cell and borrows cellular machinery to build more viruses before immune cells detect the intruders and raise the alarm. Antibody proteins that are able to stick to the virus-spike proteins, and prevent attachment to the target cells, are called neutralising antibodies: generating them is often the goal of protective vaccination.

Our infected cells make the ultimate sacrifice and invite their own destruction by displaying distress signals for T-cells, which swiftly detect and kill them. T-cells are cytotoxic powerful serial killers that can recognise peptide fragments of virus displayed on the infected cell surface. When they do, they release a payload of toxic enzymes that kill the infected cell in a kiss of death. This strategic martyrdom is organised by the immune system to deprive the virus of its replication factories and can lead to the reduction of viral load in the patient. It takes several days for antiviral T-cells to expand and antibodies to be generated. Heres the silver lining: memory cells ensure that if we encounter the same virus again, we can react immediately with pre-existing defences. Sars-Cov-2 is new to humanity so we have no protective immunological memory. Vaccines prepared using harmless parts of the virus can help us build protective memory.

The viruss enemy superpower is spreading. The virus achieves this through shedding from infected patients. Sars-Cov-2 is expert at hopping from person to person, and in some people, it achieves a stealthy existence with mild or no symptoms. Once many copies of the virus are made, it needs to jump to another host. It hitches a ride on droplets that can be coughed or sneezed to a distance of up to two metres. Droplets can survive on surfaces for several hours enabling pick-up by a new host, or they can be directly inhaled if another person is in close proximity. Studies are emerging into animal hosts so far the virus has been detected in a few ferrets, cats, tigers and dogs. No animal deaths have yet been reported, and we dont know if animals can transmit back to humans.

The age differential in fatalities for Covid-19 suggests, with some exceptions, that a healthy immune system is usually able to control infection. Meanwhile, an ageing or weakened immune system may struggle to deploy a protective arsenal. Importantly, Sars-Cov-2 cannot gain entry to our homes or bodies by itself we have to let it in. This is why official advice has centred around cleaning our hands and avoiding touching our faces.

We know that a healthy immune system is usually able to eliminate infection in a couple of weeks. However, we have no understanding of the components of our immune arsenal that contribute to this feat: some vaccines work by creating potent neutralising antibodies; other vaccines generate powerful memory T-cells. Antiviral antibodies emerge as early as three to four days after virus detection, but are they protective against future reinfection? We believe that antibodies to other coronaviruses (Sars, Mers) last from one to three years. Because this is a new virus, we dont yet know the answer to this question. Public Health England is recruiting 16,000 to 20,000 volunteers to monitor antibodies once a month for six to 12 months to confirm whether we can generate long-lasting antibody responses to Sars-Cov-2. Determining the quality of these antibodies will be important to understanding long-term protection.

What is our most potent immune weapon against Covid-19? Cytotoxic T-cells may play an important role. Immunologists and virologists are working together to discover the correlates of protection, to design vaccines that offer long-term defences against Covid-19. Years of investment in research means that we can use existing approaches to respond to this new threat, and early mobilisation of research funders, philanthropists and academics are diverting resources to bolster these efforts on an unprecedented scale. Experience has taught us that vaccines are able to eradicate infections from this planet (for instance, smallpox), and medicines against viruses that dont embed their genetic material to our own (for example, hepatitis C) can also achieve this.

Our secret weapon is research. Scientists are working hard on understanding Covid-19, and collaboration is key to this effort. But until a vaccine or treatment is available, we ought to work hard to protect ourselves and our families: isolate and prevent transmission by using physical distancing, face masks and sensible hygiene. If we all do our part, this little virus holding the world to ransom wont stand a chance.

Zania Stamataki is a senior lecturer and researcher in viral immunology at the University of Birmingham

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Here's how your body gains immunity to coronavirus - The Guardian

As the Covid-19 death toll rises, scientists are racing to understand the human body's response to the disease.

While some coronavirus antibody tests have been approved for use in the U.S., several key questions remain: What happens to the immune system after a person recovers from the virus? Could they be reinfected, and are they still a risk to others?

The Trump administration and some European countries have proposed allowing nonessential employees to return to work if they can prove they're no longer capable of spreading the virus.

This would be done by testing for coronavirus antibodies, the proteins created by the immune system in response to the presence of a virus. U.S. officials said last week that coronavirus antibody tests would soon hit the national market.

As of April 15, the U.S. Food and Drug Administration has authorized three coronavirus antibody tests. But some scientists argue that not enough is presently known about how novel coronavirus antibodies work, in order to correctly determine whether someone is immune.

"It's very likely that there are a large number of people out there that have been infected have been asymptomatic and did not know they were infected," said Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases during an April 10 appearance on CNN's New Day. Fauci is also a member of the federal coronavirus task force.

"If their antibody test is positive, one can formulate kind of strategies about whether or not they would be at risk or vulnerable to getting reinfected, this will be important for healthcare workers for first line fighters those kinds of people," he said. But those tests need to be validated, he added.

Fauci also stated that the prospect of people receiving immunity permits "is something that's being discussed" and that such a policy "might actually have some merit under certain circumstances."

But before the feasibility of such a policy can be weighed, the research must first catch up, said Dr. Helen Chu with the University of Washington's epidemiology department.

"We do think that having immunity to the virus may be protective," Chu told KUOW's The Record. "We don't know what an antibody test, at this point, means though. People who are currently infected and then recover from the virus we don't actually know what the immune signature of recovery is."

Chu said it's not clear which particular antibodies could protect a person against Covid-19.

Researchers also have yet to discover how high those antibody levels would need to be to provide immunity, or how long they would last, she said. Moreover, having antibodies for the novel coronavirus wouldn't necessarily mean a person isn't still infectious to others.

"The idea of being able to have a test to say that you're protected and you can go back and work we're not quite there yet," she said.

While there's still a great deal of uncertainty surrounding the immune system's response to Covid-19, Chu said seasonal flu epidemics could offer a window of insight.

"Once you get infected [with influenza] and you develop a protective response, that doesn't last for very long," she said. "And by the next year, you're going to be reinfected again or you're going to get another vaccine and that'll protect you for a certain amount of time but then you become susceptible again. And we don't know how coronavirus behaves."

The University of Washington's Clinical Immunology Laboratory has set out to help answer some of the looming questions about coronavirus antibodies.

"Basically, we're looking for antibodies that bind to the coronavirus proteins," said Dr. Susan Fink, assistant director of the University of Washington's Clinical Immunology Laboratory.

Thus far, the tests conducted by Fink's team have yielded varying outcomes.

"We've looked at a number of different assays, basically to look for performance characteristics are they sensitive, are they specific? And one of the things that we found is that [with] the different sort of ways that you can measure antibodies, we get very different results," she said.

Samples collected prior to the pandemic have provided some insight, albeit inconclusive, Fink said. Her team is still trying to figure out the best method for measuring coronavirus antibodies.

"We see reactivity and the way we're interpreting that is we think that those are probably false positives," Fink said, adding that her team attributes this to the presence of antibodies for other coronavirus strains not the one at the center of our current pandemic.

The Clinical Immunology Laboratory is also probing the potential for herd immunity against Covid-19: The concept of vaccinating a high percentage of people in a community to prevent them from contracting or transmitting an infectious disease, thus suppressing it.

"If we can develop an assay that we know is pretty specific for the novel coronavirus, as opposed to other coronaviruses that people have been infected with, then we can start to ask the questions about, 'Well how many people have actually developed these antibodies?'"

However, Fink said a lot more research is needed before drawing any conclusions about who might be immune to the virus.

Bill Radke contributed to this report.

Read more:
Coronavirus immunity permits for Washingtonians? 'We're not quite there yet' - KUOW News and Information

As living with the coronavirus becomes the new normal for communities all over the world, artists like Yayoi Kusama and Mo Willems have stepped forward to offer ways to self-soothe or stay entertained while practicing social distancing. Now, David Hockney, one of the most famous and successful living painters in the world, has added his voice to the conversation via a letter he sent to the Daily Mail. Controversially, Hockney is of the opinion that smoking cigarettes could provide people with a defense against the coronavirus, a stance that he backs up by citing data from the outbreak in China that points to fewer smokers being admitted to the hospitalfor COVID-19 treatment.

Smokers have developed an immune system to this virus, Hockney wrote. With all these figures coming out, its beginning to look like that to me. Im serious. Additionally, the artist weighed in on his own mortality. Ive smoked for more than 60 years, but I think Im quite healthy, Hockney added. How much longer do I have? Im going to die of either a smoking-related illness or a non-smoking-related illness, Hockney wrote. While this particular flavor of contemplative nihilism is certainly entertaining coming from one of the most celebrated artists in the world, Hockneys theory that smokers are less likely to get the coronavirus is problematic at best and dangerous at worst.

SEE ALSO: Marina Abramovis Dangerous Work Has Given Her an Interesting Perspective on Coronavirus

The World Health Organization writes that smokers are in fact more likely to be vulnerable to COVID-19, due to the fact that potentially contaminated fingers and cigarettes are coming into frequent contact with a persons open mouth when they smoke. Smokers may also already have lung disease or reduced lung capacity, which would greatly increase risk of serious illness, WHO continues. Additionally, although its clear that more research is warranted, recent studies are beginning to trickle out which indicate that smoking is likely associated with the negative progression and adverse outcomes of COVID-19.

Its possible Hockney swiped his theory from rumors that nicotine has the ability to downregulate the enzyme that binds COVID-19 to humans, which has been getting a decent amount of circulation on Twitter. Its a theory that has little to no scientific basis, particularly in the face of the mounting evidence that smoking increases the risk of COVID-19 symptoms growing more severe. Right now, its important to practice common sense and remember that cigarettes have been proven to be really, really bad for you. Until the world knows enough about coronavirus in order to develop a vaccine, its probably best to assume that smoking wont save you.

Go here to read the rest:
David Hockney Says Smokers Have Developed an Immune System Against Coronavirus - Observer

Boosting immunity is a hot topic in the fall as cold and flu season approaches; however, this is a conversation we should have all year long. It is especially popular in light of the recent COVID-19 pandemic.

What does boosting immunity mean? Our bodies have a sophisticated immune system guarding us against disease. Our lifestyle choices impact our ability to strengthen or weaken our immune systems. Behaviors such as tobacco and excessive alcohol use weaken our defense system while consuming a healthy diet and getting our bodies moving works to strengthen it.

While boosting our bodys immune response is not a guarantee against infection, it is one more tool in our toolbox to decrease risk. Therefore, there are many lifestyle choices we can make to help boost immunity:

1. Manage stress: There are a variety of ways to do this, and each person manages their stress differently. Many of us turn to food to help manage stress. Instead, you could consider journaling, meditation, deep breathing exercises, yoga, tai chi, qi gong or making a gratitude list. Other ideas include calling a friend, trying something new, being outside in nature, doing something you enjoy, or expressing yourself creatively with music or art.

2. Avoid tobacco and alcohol: Tobacco and alcohol contribute to chronic inflammation and the increase of toxins in your body. These toxins decrease your bodys ability to make white blood cells and fight off other invaders, like viruses and bacteria. If you need more support to quit, UW Health is here to help: Smoking 1-800-784-8669; AODA (608) 282-8270

3. Stay hydrated: Drinking water helps your body naturally eliminate toxins and keeps the system flowing smoothly. The goal of drinking at least 64 ounces or eight cups of water each day may sound daunting, but there are many options to help you reach this, like flavored water, fruit infused water, sparkling water, unsweetened tea, or herbal tea. Whatever you choose, make it calorie-free and sugar-free.

4. Get sleep: When it comes to sleep quality is more important than quantity (ideally 7-9 hours each night),. To improve your quality of sleep, consider: avoiding technology or screens at least 90 minutes before going to bed; consider reading, journaling, or listening to soft music before bed. Make sure your bedroom is cool, dark, and quiet, and avoiding turning on the TV while lying in bed.

5. Move your body: Regular exercise helps to fight inflammation and strengthen your immune system. Find ways to incorporate physical activity into your day, such as taking extra steps while doing household chores. As little as 20 minutes of movement can be effective, with a goal of moving your body each and every day. If youre active at least 150 minutes per week, youre doing great keep up the good work!

6. Choose anti-inflammatory foods: Many are stocking up on canned or boxed foods, but theyre missing a key opportunity to strengthen their immune system with nutrient-dense, antioxidant rich foods. Instead, continue purchasing whole foods, such as a colorful rainbow of fruits and veggies (frozen and canned count), whole grains, nuts, beans and lentils, and shelf-stable lean proteins like frozen or canned chicken and fish.

7. Stay connected: Its in our human nature to connect and interact with others, which makes social-distancing challenging, frustrating, and at times depressing. Even a brief, virtual connection with others can boost our positive emotions, which have been shown to improve our immunity. During this time, stay in touch with friends and family, even if it has to be through FaceTime, Skype, Zoom, texting, or the age-old phone call.

For more resources:

http://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public

http://www.cdc.gov/coronavirus/2019-ncov/prepare/prevention.html

More here:
Lifestyle tips to boost immunity - Daily Union

Those quarantine snacks sure look like tempting. But try to eat them in moderation, says Dr. Hans-Rudolf Berthoud, who studies neurobiology and nutrition at Pennington Biomedical Research Center.

Pandemic or not, Berthoud reminds us: The nutritional value of natural foods is so much better than the nutritional value of snack foods. The more processed the food is, the less nutritionally rich.

There isnt one single answer for why we want to constantly snack, according to Berthoud. But for some, he says, the urge to snack could be tied to genetic obesity.

Berthoud does think the stay-at-home order has a silver lining: Families can now cook together more often.

When cooking, youll want to incorporate carbohydrates and proteins into your diet. But you dont need to eat meat every day, Berthoud says. Eating a portion of meat two to three times per week is enough. Instead try to opt for protein from beans, vegetables or fish, which is filled with unsaturated fats that can improve heart health and your overall immune system.

He also says some of that family time should include healthy activities pre-dinner, such as going for walks for an hour or two per day to achieve at least 10,000 steps per day. And when you leave the house for essential services, take the stairs and park farther away from store entrances.

Exercise also means you dont have to spend as much time constantly watching your caloriesjust dont take it too far.

When doing exercise, you can eat a little more [afterward], but for some people this is not productive because theyll just pig out and eat a lota whole lot, Berthoud says.

Drink lots of water (and skip the sugary sodas!), and get at least eight hours of sleep per night to boost your immune system.

These, he says, are small behavioral steps to change your habits for the better. Those habits might also help the quarantine snacks last a little longer, too.

Read more:
How to stay healthy and boost your immune system during the pandemic, according to a Pennington researcher - 225 Baton Rouge

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Editorial: The economy needs an immune system - TribLIVE

COVID-19 does not impact us all the same. In fact, a growing body of evidence finds that the virus seems to hit men harder than women.

Early in the epidemic, researchers' best guess was that the difference could be chalked up to higher rates of smoking among men, which may have made them more vulnerable to this respiratory illness.

But now, as new data reveals dramatically stark sex disparities, researchers have proposed new theories tied to biological differences and cultural norms that could help explain why men appear to be more vulnerable to this disease.

Researchers first learned of sex differences early on in the COVID-19 epidemic when data out of Wuhan, China, found that men accounted for the majority of cases and up to 75% of deaths.

Next was Italy, the nation with the highest total deaths in the world, where the man-to-woman ratio for death is 80% to 20%.

Here in the United States, an analysis of 1.5 million tests found that men were more likely to be COVID-19 positive when they were tested, according to coronavirus response coordinator Dr. Deborah L. Birx. Women have actually been tested more often than men.

And according to a Centers for Disease Control and Prevention study covering 14 states and nearly 10% of the U.S. population, more than half of COVID-19-associated hospitalizations happened in men. In New York state, the epicenter in the U.S. with the highest number of cases and deaths, men make up nearly 60% of the deaths. None of the aforementioned studies, however, drilled down into COVID-19 rates for gender minorities, including people who identify as transgender or do not identify as either gender.

Looking back to viral epidemics of the past, these differences are not unique to the virus that causes COVID-19.

COVID-19 appears to follow the trend of previous infections with SARS and MERS [in that] men are affected more often than women," said Veena Taneja, an associate professor of immunology at The Mayo Clinic.

As researchers try to understand why men are more affected than women, smoking initially seemed like the obvious culprit. With more than 1.1 billion smokers in the world, far more men smoke than women. Often portrayed as habits that evoke wealth, power and sexual success, smoking is instead linked to lung disease, heart disease, cancer and death.

China is the largest producer and consumer of tobacco in the world, and more than half of adult men there are current smokers. Men are more likely to be cigarette smokers in the majority of countries including China, the U.S., Italy and others.

But as data accumulated, experts realized that smoking couldn't stand alone as the reason. For example, in countries like Spain, the rate of smoking among men and women is approximately the same, yet men still represent the majority of cases and deaths.

Now, researchers are looking beyond smoking to other lifestyle factors, such as diet and alcohol consumption. And they're exploring other possible causes -- from the cellular level to social and cultural norms -- to help understand why men are falling victim to this disease.

Men are consistently more likely to drink and almost twice as likely to binge drink as women. Alcohol has a longstanding association with adverse immune-related health factors like susceptibility to pneumonia, acute respiratory distress syndrome (ARDS), slower recovery from infection and much more.

A study from China looking at 21 different hospitals found that almost half of the patients who died of COVID-19-related pneumonia had high blood pressure and nearly 30% had diabetes.

Prior research has shown a powerful interaction between high blood pressure and the immune system, indicating that people with high blood pressure may be less well equipped to fight off infections.The same is true of uncontrolled diabetes, which can cause the immune system to fail in its ability to control infections, making people more susceptible.

Taneja of the Mayo Clinic has studied differences in the immune systems of men and women and found significant differences in other diseases. She said the differences can be due to a number of factors.

Occupational hazards that affect the immune system and lungs are more common in men, and then there are sex hormones which affect the immune system differently, she said.

Studies suggest that there are many differences between men and women in immune response due to sex hormones (androgen and estrogen), sex chromosomes (XX, XY), regulatory genes (genes that tell the body what decisions to make) and the ability to produce antibodies (proteins that tell the body about the virus).

Taneja explained that male hormones are known to suppress immune response.

However, due to estrogen, females generate higher immune response and make antibodies which can clear the infection. She said estrogen is also known to change the bacterial composition in our guts. Bacteria help us fight infections.

Sex chromosomes may also help with the immune response in women.

Women have XX chromosomes and men carry XY" [and] each X chromosome helps with the immune response by providing women [a] double dose," Taneja said.

Jay Bhatt, a practicing internist and chief clinical officer at Surgisphere, agrees, noting that having two copies of the X chromosome may be helping bolster the immune response to coronavirus."

Severity of COVID-19 is not the only factor impacted. Women may also have a higher chance of being immune down the road. A comparison of 331 patients in Wuhan showed that after recovering from more severe cases of COVID-19, women had higher levels of antibodies. This is important because research suggests higher antibody levels may be related to immunity.

Some researchers have proposed that these differences in the immune system were forged over thousands of years of evolutionary history.

During evolution, nature, to preserve mankind, and for progeny, has selected women to be stronger during childbearing age. Women are less susceptible to get infections and can fight them by generating a robust response, said Taneja.

Other researchers have suggested that society and culture may play a role, with gendered cultural norms guiding certain behaviors. In China, Hong Kong, Italy, South Korea, and many other countries, experts found that women may have been protected, in part, because they were more likely to stay home when schools closed.

Another cultural norm may be that men are expected to "tough it out" and wait to seek treatment and testing. White House coronavirus response coordinator Birx explored this theory in a briefing last week, referring to the fact that men are less often tested but more likely to test positive.

It gives you an idea about how men often dont present in the healthcare delivery system until they have greater symptomatology, Birx said. This is to all of our men out there, no matter what age group: If you have symptoms, you should be tested and make sure that you are tested.

Scientists, doctors and policy makers agree that we need a better understanding of the potential gender differences to effectively fight COVID-19, prevent further spread and to identify safe treatments and vaccines.

Delaram J. Taghipour, MD, MPH, MBA is a preventive medicine resident at Johns Hopkins Bloomberg School of Public Health and is a contributor to ABC News.

ABC News Dr. Jay Bhatt contributed to this work.

Continued here:
Why coronavirus can make some severely ill and others hardly at all - ABC News

Although there is no cure or specific treatment for COVID-19, there are some things you can do to strengthen your immune system against the coronavirus.

Here are scientifically supported ways to help fight off illness.

The amount of sleep youre getting each night can make a big difference in your bodys ability to fight infection, health experts say.

One 2015 study found that people who sleep less than six hours each night were more likely to catch a cold than those who slept seven or more.

The U.S. Centers for Disease Control and Prevention recommends that adults sleep at least seven hours each night. Going to bed and waking up at the same time each day, sleeping in rooms without electronics or screens, and avoiding large meals, caffeine and alcohol before bed are ways to improve your sleep.

Research shows that regular, moderate exercise can reduce inflammation and support your immune systems cells.

Health experts recommend moderate exercise at least 150 minutes each week, or about 20 minutes a day. You can also do 75 minutes of more intense exercise a week, or do a combination of both.

Moderate exercise includes brisk walking, biking, swimming or jogging, while more intense exercise includes running or other cardio.

Staying hydrated isnt directly connected to preventing disease, but it can help with your overall health.

Healthline says you should drink enough water each day to make your urine a pale yellow, while other health experts recommend drinking eight glasses of water a day, or about half a gallon.

In this age of uncertainty, lowering your stress level is easier said than done. But health experts say high stress levels have negative impacts on your bodys ability to fight off illness.

A series of studies in the 1990s led by Sheldon Cohen, a professor of psychology at Carnegie Mellon University, found that people who reported higher levels of stress were more susceptible to the common cold.

Cohen led another study published in 2012 that found psychological stress can cause the body to lose its ability to regulate its inflammatory response, which may promote the onset and progression of some diseases.

Health experts recommend stress management techniques such as avoiding social media, meditating, practicing controlled breathing, doing yoga, or other activities that help you feel relaxed.

No one food will prevent infection, but following basic dietary guidelines, like eating plenty of fruit, vegetables and protein is a good start.

There are several specific items you can add to your diet to strengthen your immune system and overall health.

Health experts recommend eating certain foods that are high in vitamin C, like red bell peppers, broccoli, strawberries, spinach and citrus fruits like oranges, lemons and grapefruit. Sunflower seeds and almonds are recommended because they are high in vitamin E, while other foods, like yogurt, garlic, poultry and chickpeas, have other health benefits.

Ginger, turmeric, green tea, papayas, kiwis, shellfish and mushrooms are also good items to add to your diet, health experts say.

Texans may be eager to take advantage of alcohol delivery and to-go cocktails since Gov. Greg Abbott waived regulations restricting restaurants from providing such services. But health experts say you should be careful about how much you drink if you want to put your body in a good position to fight off disease.

Research shows excess alcohol consumption can make your body more susceptible to respiratory illness, including pneumonia and other lung diseases. It can also decrease your body tissues ability to heal wounds. Health experts say this is true for chronic and binge drinkers.

While health experts say the occasional glass of wine at dinner wont hurt you, you should avoid overdoing it.

Health experts have differing opinions on the use of vitamins and other supplements. They can be pricey and they dont prevent anyone from catching a disease, no matter how much you take.

Health experts say other disease prevention methods, like frequent hand-washing, will help you more than any supplement will.

However, there is some evidence that regularly taking certain supplements can reduce the duration of certain illnesses.

One 2013 study found that regularly taking vitamin C reduced the duration of colds in adults by 8% and in children by 14%. A similar 2017 study found that the duration of colds among people taking more than 75 mg of zinc per day was 33% shorter than those who didnt take zinc.

An exception to the supplement rule that most health experts agree on is vitamin D, which helps your body fight off infection. You can get vitamin D naturally through certain foods, like salmon, or through exposing your body to sunlight. Some health experts recommend taking a vitamin D supplement during winter months, when sunlight is harder to come by.

If youre going to take supplements, its important not to take too many. Some health and wellness influencers and YouTubers have recommended taking extremely high doses of supplements in recent weeks in response to COVID-19. But health experts warn that can be dangerous. Taking high doses can cause dizziness, nausea and headaches and damage your organs in more serious cases.

Healthline recommends taking supplements that have been tested by a third party, such as United States Pharmacopeia, NSF International and ConsumerLab, because supplements arent regulated by the U.S. Food and Drug Administration.

Practicing habits to strengthen your health does not mean you should stop following other public health guidelines. You should still practice social distancing, avoid nonessential errands, wash your hands often, wear a face mask in public and follow stay-at-home orders, health experts say.

Read more:
Here are the best ways to strengthen your immune system during the coronavirus pandemic - The Dallas Morning News

NEW YORK, April 15, 2020 /PRNewswire/ -- The stem cell therapy market was valued at US$ 1,534.55 million in 2019 and is estimated to reach US$ 5,129.66 million by 2027; it is expected to grow at a CAGR of 16.7% from 2020 to 2027.

Read the full report: https://www.reportlinker.com/p05882135/?utm_source=PRN

The increasing awareness related to the stem cells therapy in effective disease management and growing demand for regenerative medicines are the key factor driving the stem cell therapy market. However, high cost related of the stem cell therapy limits the growth of the market.Stem cell research has been widely investigated globally for various medical applications, especially for the treatment of humans.This raises the importance of creating public awareness about stem cell research and its clinical potential.

The main role of stem cells is in the replacement of dying cells and reconstruction of damaged tissues. Based on the extensive stem cell research, many scientists have claimed that these cells could probably be used in the treatment of various diseases, including cancer and cardiovascular disease.There is a large number of potential treatment procedures that are undergoing clinical trials, and a notably few stem cell therapies have won FDA (i.e., US Food and Drug Administration) approval for clinical usage. For instance, in 2019, the FDA approved Fedratinib for the first-line treatment for myelofibrosis. Moreover, stem cell therapies are widely used in bone marrow transplantation, and these therapies have benefited thousands of people suffering from leukemia. Hematopoietic stem cells are used for treating more than 80 medical diseases, including immune system disorders, blood disorders, neurological disorders, metabolic disorders, genetic disorders, and several types of cancers, such as leukemia and lymphoma; this is also likely to boost the demand for this treatment procedure during the forecast period. Researchers are further investigating the use of stem cell therapies in the treatment of autoimmune disorders.

The global stem cell therapy market has been segmented on the basis of type, treatment, application type, and end user.Based on type, the market has been segmented into adult stem cell therapy, induced pluripotent stem cell therapy, embryonic stem cell therapy, and others.

The adult stem cell therapy held the largest share of the market in 2019; however, induced pluripotent stem cell therapy is estimated to register the highest CAGR in the market during the forecast period.Based on treatment, the stem cell therapy market has been segmented into allogeneic and autologous.

The allogeneic segment held a larger share of the market in 2019; however, the market for the autologous segment is expected to grow at a higher CAGR during the forecast period.Based on application type, the stem cell therapy market has been segmented into musculoskeletal, dermatology, cardiology, drug discovery and development, and other applications.

The musculoskeletal segment held the largest share of the stem cell therapy market in 2019, whereas the drug discovery and development segment is expected to report the highest CAGR during 20202027. Based on end user, the market has been segmented into academic and research institutes, and hospitals and specialty clinics. The academic & research institutes held the largest share of the market in 2019, and it is also expected to report the highest CAGR during the forecast period.Several essential secondary sources referred to for preparing this report are the FDA, World Health Organization (WHO), Organisation for Economic Co-operation and Development, National Institutes of Health, Spanish Agency for Medicines (AEMPS), Japanese Society for Regenerative Medicine, and Indian Council of Medical Research, among others.

Read the full report: https://www.reportlinker.com/p05882135/?utm_source=PRN

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

__________________________Contact Clare: clare@reportlinker.comUS: (339)-368-6001Intl: +1 339-368-6001

Excerpt from:
Stem Cell Therapy Market to 2027 - Global Analysis and Forecasts by Type; Treatment; Application; End User, and Geography - Salamanca Press

Gum recession puts patients at risk of developing decay, causes tooth sensitivity, and creates an unattractive smile. "Gum recession is most commonly caused by gum disease, which affects nearly 65 million Americans annually. Many patients avoid treatment because of the painful, invasive nature of a gum graft that typically uses gum tissue from the roof of the mouth, increasing post-operative pain and suffering. The RejuvaGum Lift offers patients a gentle yet effective alternative to gum grafting, with less recovery time and enhanced healing," says Dr. Alina Krivitsky.

The Brentwood periodontists utilize cutting-edge technology to offer their patients advanced periodontal care. "Several samples of a patient's blood are spun in a centrifuge to separate the platelets, white blood cells and fibrin. When applied directly to a wound, the proteins in the fibrin encourage faster healing by causing the wound to close more quickly, and increase blood flow to the site. The extra boost of stem cells and growth factors assist in soft tissue regeneration around the exposed roots, and by utilizing the patient's own immune system to heal, the risk of infection is almost none," says Dr. Aalam.

To learn more about the RejuvaGum Lift treatment for gum recession, please visit https://implantperiocenter.com/or contact them at 310-504-1845.

About the CENTER for Advanced Periodontal & Implant Therapy

At the CENTER for Advanced Periodontal & Implant Therapy, Dr. Aalam and Dr. Krivitsky utilize advanced technology coupled with cutting-edge techniques to provide minimally-invasive, comfortable and effective periodontal care. As the only dual-board certified practice in Brentwood, California, they are committed to providing restorative periodontal therapies to rejuvenate the aesthetics, health, and function of the gums and teeth, to help patients achieve a healthier smile.

Contact: Charlene Yashouafar, Marketing DirectorSocial Lighthouse[emailprotected](213) 403-1407

SOURCE The CENTER for Advanced Periodontal & Implant Therapy

WELCOME TO YOUR LOS ANGELES PERIODONTISTS

Link:
Los Angeles Periodontists use blood-derived growth factors as an alternative to treating gum recession - PRNewswire

Biotech company Mogrify is deploying its proprietary direct cellular conversion technology to develop cell therapies in a variety of disease areas, including auto-immune, musculoskeletal, respiratory diseases and in cancer immunotherapy.The platform utilizes data from next-generation sequencing and cellular networks to identify transcription factors or small molecules required to directly convert a cell, addressing key challenges that are typically associated with the safety and efficacy of cell therapies.Technology Networks recently spoke with Joe Foster, COO, Mogrify, to learn more about the platform, the challenges encountered in developing cell therapies, and to gain Mogrify's insights on the future of this exciting research space.Molly Campbell (MC): What were some of the major highlights for Mogrify in 2019?Joe Foster (JF): In the past year, Mogrify has solidified its reputation as a pioneer in the expanding field of cell therapy. Using a systematic, data-driven approach, our innovative cell conversion platform addresses many of the challenges impeding systematic discovery, process development and the manufacturing processes.At an operational level, Mogrify has seen unprecedented growth in the last year, with emphasis on world-class science. We have established a leadership team with unparalleled track records, including the appointment of Dr Darrin M. Disley OBE, as CEO and Dr Jane Osbourn OBE, as Chair. Looking forward and with plans to boost our team to 70 individuals working across all disciplines, Mogrify has also moved operations to the new Bio-Innovation Centre in Cambridge, giving our team access to state-of-the-art facilities to continue their work in developing novel approaches to cell therapy.Mogrify received MSDs Innovation Award at the 15th Annual Scrip Awards, in acknowledgement of our potential to transform future cell therapies. Dr Jane Osbourn OBE was also the first female to win the Lifetime Achievement Award, recognizing her significant contributions to the biotech industry. Mogrifys significant fundraising success was also marked at the prestigious European Lifestars Awards, which celebrates excellence in the life science industry. Here, Mogrify was recognized as the Seed Stage Finance Raise of the Year.MC: In Mogrify's opinion, what key trends can we expect to see in the cell therapy space in 2020?JF: Many of the current approaches to cell therapy involve first converting cells back into a stem cell-like stateinduced pluripotent stem cellsbefore then converting them into the cell type required.Mogrify plans to lead the movement towards direct cell conversion, or transdifferentiation, where cells can be transformed from one cell type to another, without having to go through an intermediate pluripotent stage. Direct conversion of cells would enhance the speed of cell therapy development, as cells do not need to use traditional developmental pathways to reach a mature state.

Another bottleneck in the delivery of cell therapies is that most approaches rely on autologous transplants, which are carried out using patient-derived cells. Future innovations are moving towards using allogeneic therapies, where the cells used for therapy are derived from a healthy donor. Such advances are paving the way towards the development of universal donor cells, which would turn cell therapies into off-the-shelf treatments, enhancing the scale and accessibility of the treatments.

Finally, cell therapy methods are likely to move from ex vivo approaches (where cells are isolated from the patient, reprogrammed, and delivered back into the patient), to in vivo approaches, where cell therapies are delivered directly to the recipient, for example, through the use of small molecules present in a reprogramming cocktail or direct gene editing. In vivo technologies would, therefore, be able to reprogram cells directly in living humans, expanding the scope of cell therapy in a clinical setting. Overall, future cell therapies will have the capacity to be more effective, safer, and widely accessible.

MC: What are the key challenges that currently exist when developing and testing cell therapies? How does Mogrify hope to overcome such challenges?JF: The biggest challenges in producing cell therapies surround the efficacy, safety profile, and scalability of clinical treatment regimes. To make treatments safer, delivered cells must bypass the host immune system. This can be achieved with autologous therapy, but comes at the cost of scale and efficiency, as the patients cells need to be extracted, cultured, and reprogrammed before treatment can be delivered. Genetic engineering technologies (such as CRISPR/Cas9) that can be employed to remove the antigenic potential of allogeneic cell therapies (e.g. CAR-T) can be used in conjunction with such treatments, but this brings an additional layer of complication.Another difficulty comes from the technical challenges associated with generating, culturing, and expanding the required cells. In theory, any cell type can be derived from pluripotent cells. However, determining precisely how to generate any cell from pluripotent cells is conceptually and practically complex. Each cell type would require a distinct combination of transcription factors (or small molecules) and optimized culture conditions to ensure robust conversion into the desired phenotype. These technical challenges are associated with slow progress and poor efficiency in deriving reliable therapeutic cells.

Mogrify aims to tackle these hurdles with solutions involving big data, computational predictions, and bioinformatics. Mogrifys proprietary algorithm uses next generation sequencing data to predict the combination of transcription factors necessary to reliably convert any cell type into another cell type. Mogrifys technology provides a framework for direct cell conversion, and can also identify the best culture conditions to ensure that the cell populations remain stable and viable. This greatly improves cell therapy efficiency, as mature cells are created without the often arduous and imprecise process of differentiating cells from pluripotency.

Mogrifys technology is also compatible with in vivo cell therapies, as it can identify a combination of small molecules that will drive the necessary transcriptional networks to create the cells of choice. Therefore, Mogrifys technology can also be applied to overcome safety issues associated with allogeneic ex vivo approaches, and has the potential to greatly enhance the scale at which cell therapies can be delivered.MC: Are you able to tell us more about the latest developments in Mogrify's pipeline?JF: Currently, Mogrify is focused on applying the platform to musculoskeletal disorders, cancer immunotherapy, and auto-immune, ocular and respiratory diseases. Specifically, Mogrify is committed to identifying opportunities in regenerative medicine contexts, where direct cell conversion could have strong therapeutic potential.The current lead musculoskeletal program is in the development of chondrocytes for the treatment of cartilage defects and osteoarthritis. Mogrifys platform identified a cocktail of small molecules that successfully drives the conversion of fibroblast cells to chondrocytes, which has been proven to form functional hyaline cartilage in vitro. This can even be performed using an allogeneic approach without the need for gene editing (as the cartilage is immunopriviliged). Thus, it represents an opportunity for an off-the-shelf therapy that could be a relatively inexpensive and accessible treatment. At present, this treatment is in pre-clinical stages, and has a powerful potential for success in regenerative cartilage therapy. Similarly, an in vivo method of transdifferentiating osteoarthritic chondrocytes to healthy cells is being investigated in ongoing studies using a cocktail of small molecules.

Joe Foster, COO, Mogrify was speaking to Molly Campbell, Science Writer, Technology Networks.

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Leading the Movement Towards Direct Cell Conversion: An Interview With Mogrify - Technology Networks

Throughout history, the nations colleges and universities have set the foundation for innovation and social change. Weve uncovered the secrets of DNA. Weve unleashed bioengineering. We have harnessed intellectual power to create new technologyoften through the partnerships between land grant colleges and local industries and agriculturebringing the latest science to where it was needed. And we have done it all while demanding intellectual rigor and a sharp focus on the common good for society.

At Boston University, the Center for Regenerative Medicine at BUs Medical Center, alerted by colleagues at the University of Washington in Seattle, coordinated with MITs Broad Institute as well as Harvard to produce a test for the virus with a turn around time of within 24 hours. More than 50 volunteered in this round the clock effort. Testing is now underway. Rutgers University has launched its own virus testing program. Its RUCDR Infinite Biologicsa part of the Universitys Human Genetics Institute of New Jerseyis now capable of testing tens of thousands.

Tiny Bay Mills Community College, a Michigan tribal college of fewer than 500 students, has used 3-D technology to design and now produce 1,000 face masks for first responders every week.

Institutions of higher education, large and small, can and do play a significant role in serving our country and our world at this critical moment in history. But our work starts at home. Whats required is a community approach, as local areas are impacted in distinct ways while this crisis unfolds.

I learned the power of community response to overwhelming challenges at the American University of Nigeria. I served there as president when Boko Haram began to surge near the campus and federal assistance was nowhere to be found. The university brought the community together and kept the terrorist group at bay and fed refugees.

Drawing on that experience, when I arrived at Dickinson three years ago, I immediately began to gather with community members to identify their most pressing issues and to connect them with college resources. What started out as a dozen people has now grown to more than 50 representing nearly every sectornonprofits, school districts, health care, government and business. We are meeting remotely in the age of COVID-19, but the relationships we have built have allowed us to respond quickly in a coordinated manner to the communitys growing needs.

Working with Carlisle Borough, the Chamber of Commerce and Community CARES partnered to convert the Stuart Community Center into a shelter for the homeless. UPMC Carlisle anticipated a potential need for housing and shelter for its exhausted medical workers; Dickinson stepped up and agreed to make space available in our vacated residence halls. Local businesses needed an online presence to offer goods and services, but lacked the know-how; Dickinson students are developing e-commerce websites for those businesses. Our organic farm is supplying much-needed fresh produce for the community.

Colleges areand should beat the epicenter of community responses to COVID. They can and should be the assembly point for community action. Its imperative that colleges start building or strengthening relationships with leaders in their communities now, to help in recovery and before the next crisis or disaster occurs.

When students return to class, they will return to communities that have changed in myriad ways. The old ideas, approaches and leadership simply wont do. Our students and young people are the ones we will need to help us with the necessary reconstruction. Those students will rely on the knowledge and problem-solving skills our institutions of higher learning should be providing.

In these difficult times, the country must demand much of its colleges and universities. Communities must know that we are in the trenches with you, and that we are all of us prepared to do more. When students return to our campuses we should work together to build a program of national service. This is how we will rebuild America and prepare the next generation for more unprecedented challenges.

Margee M. Ensign is president of Dickinson College, in Carlisle. Previously, Ensign served as president of the American University of Nigeria, where she developed aid and relief programs for hundreds of thousands of internally displaced people fleeing Boko Haram.

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Community resilience is facing Its greatest threat, and colleges are helping | Opinion - pennlive.com

TAIPEI, April 16, 2020 /PRNewswire/ -- ACRO Biomedical Co., Ltd., the first company in the world to utilize "supercritical CO2 extraction technology" on cleansing animal tissues and organs, is gradually showing impressive results on the global patent map. In 2019, ACRO acquired two patents from Japan. One for the decellularized cartilage graft, and another for the decellularized cornea. The great news continues with ACRO acquiring patents from the USA and Korea successively for the decellularized cornea in March 2020.

ACRO has acquired patents from Taiwan, the USA, Japan, and Korea for the preparation of acellular corneas by utilizing supercritical CO2 extraction technology. Patents from India, EU, Hong Kong, andmainland China are also on their way. The wish to benefit patients around the world with damaged cornea is very promising.

The CEO of ACRO Biomedical, DJ Hsieh, said that the traditional way to utilize supercritical CO2 extraction technology is to extract herbal medicine and essential oil. After many years of research and development, ACRO has successfully utilized the technology on cleansing animal tissues and organs including skin, bone, cartilage, cornea, blood vessel, nerve, heart, kidney, liver, pancreas, and brain. Many of the products have received approval from USFDA, Singapore, Vietnam, Philippines, and Taiwan FDA. Furthermore, ACRO has licensed out Collagen Ophthalmic Matrix to Oculus BioMed from Australia, and also signed an exclusive strategic partnership agreement with Marubeni Corporation from Japan, laying the foundation for the global market.

The advantages of ACRO's technology application are its high efficiency, low cost, time-saving, and when compared with other products of the same type that are decellularized with acid-base solutions or organic solvents, it greatly reduces the chance of allergy and immune rejection. It is a great help for the future development of the global regenerative medicine.

SOURCE ACRO Biomedical Co., Ltd.

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ACRO Biomedical's Proprietary Technology Leads the World with Patents from Taiwan, Japan, USA, and Korea - Yahoo Finance

In this study, once-daily, flexible-dose (50-75 mg) treatment with SEP-363856 demonstrated a statistically significant and clinically meaningful improvement in the Positive and Negative Syndrome Scale (PANSS) total score compared to placebo after four weeks of treatment (-17.2 vs. -9.7, respectively; p=0.001). Patients treated with SEP-363856 also showed improvement in the overall severity of illness as assessed by the Clinical Global Impression Scale Severity (CGI-S) (p<0.001). In addition, improvement was observed in all major PANSS (positive, negative and general psychopathology) subscales (p<0.02). SEP-363856 was well tolerated throughout the study and the overall discontinuation rate was comparable for SEP-363856 and placebo.1

These data represent an exciting step forward in schizophrenia research. The steps that led to identifying this new mechanism of action, targeting TAAR1, were very novel and they reflected a courageous and innovative approach by Sunovion to identifying new ways to treat schizophrenia, said John Krystal, M.D., Chair of Psychiatry and Co-Director, Yale Center for Clinical Investigation at Yale School of Medicine and co-author of the NEJM publication. For the last 60 years, antipsychotics that bind to dopamine receptors have been the standard of care, despite their side effect profile. It is my hope that these results for SEP-363856 support a new schizophrenia treatment for people who have been diagnosed with this serious mental health condition. SEP-363856 could have a big impact on people with schizophrenia, their families, and on the public health burden posed by schizophrenia.

SEP-363856 is a novel trace amine-associated receptor 1 (TAAR1) agonist with serotonin 1A (5-HT1A) agonist activity that is being evaluated in patients with schizophrenia. SEP-363856 does not bind to dopamine 2 (D2) or serotonin 2A (5-HT2A) receptors, which are thought to mediate the effects of currently available atypical antipsychotic medicines. SEP-363856 is being studied in the DIAMOND (Developing Innovative Approaches for Mental Disorders) Phase 3 global development program for schizophrenia with additional indications under consideration. The U.S. FDA granted Breakthrough Therapy Designation for SEP-363856 for the treatment of schizophrenia in May 2019.

Publication of these findings in the New England Journal of Medicine demonstrates the potential of SEP-363856 to be the first TAAR1 agonist for the treatment of schizophrenia, said Kenneth Koblan, PhD, Chief Scientific Officer of Sunovion. This innovative approach to the treatment of schizophrenia may provide a completely new option for the 23 million people worldwide who live with this serious mental health condition. Sunovion is committed to developing new treatment options for these patients and continuing to study SEP-363856 to further evaluate its clinical benefit in schizophrenia and other neuropsychiatric conditions.

As noted in the NEJM publication, in the six-month, open-label extension study, SEP-363856 demonstrated continued improvement across efficacy measures, including the PANSS total score, the CGI-S score, and the Brief Negative Symptom Scale (BNSS) total score and appeared to be safe and well-tolerated.

About SEP-363856 SEP-363856 is a TAAR1 agonist with 5-HT1A agonist activity that is under investigation for the treatment of schizophrenia and other psychiatric conditions. Sunovion discovered SEP-363856 in collaboration with PsychoGenics based in part on a mechanism-independent approach using the in vivo phenotypic SmartCube platform and associated artificial intelligence algorithms. SEP-363856 is being studied in a global Phase 3 development program for schizophrenia (DIAMOND) with additional indications under consideration. The U.S. FDA granted Breakthrough Therapy Designation for SEP-363856 for schizophrenia in May 2019.

About Schizophrenia Schizophrenia is a chronic, serious and often severely disabling brain disorder that affects more than 23 million people worldwide2 and approximately one in 100 adults (about 2.4 million people) in the United States.3 It is characterized by positive symptoms, such as hallucinations, delusions and disorganized thinking as well as negative symptoms, such as lack of emotion, social withdrawal, lack of spontaneity and cognitive impairment that includes problems with memory, attention and the ability to plan, organize and make decisions.2

About Sunovion Pharmaceuticals Inc. (Sunovion) Sunovion is a global biopharmaceutical company focused on the innovative application of science and medicine to help people with serious medical conditions. Sunovions vision is to lead the way to a healthier world. The companys spirit of innovation is driven by the conviction that scientific excellence paired with meaningful advocacy and relevant education can improve lives. With patients at the center of everything it does, Sunovion has charted new paths to life-transforming treatments that reflect ongoing investments in research and development and an unwavering commitment to support people with psychiatric, neurological and respiratory conditions.

Headquartered in Marlborough, Mass., Sunovion is an indirect, wholly-owned subsidiary of Sumitomo Dainippon Pharma Co., Ltd. Sunovion Pharmaceuticals Europe Ltd., based in London, England, and Sunovion Pharmaceuticals Canada Inc., based in Mississauga, Ontario, are wholly-owned direct subsidiaries of Sunovion Pharmaceuticals Inc. Additional information can be found on the companys websites: http://www.sunovion.com, http://www.sunovion.eu and http://www.sunovion.ca. Connect with Sunovion on Twitter, LinkedIn, Facebook and YouTube.

About Sumitomo Dainippon Pharma Co., Ltd. Sumitomo Dainippon Pharma is among the top-10 listed pharmaceutical companies in Japan, operating globally in major pharmaceutical markets, including Japan, the U.S., China, and the European Union. Sumitomo Dainippon Pharma aims to create innovative pharmaceutical products in the Psychiatry & Neurology area, the Oncology area and Regenerative medicine/Cell therapy field, which have been designated as the focus therapeutic areas. Sumitomo Dainippon Pharma is based on the merger in 2005 between Dainippon Pharmaceutical Co., Ltd., and Sumitomo Pharmaceuticals Co., Ltd. Today, Sumitomo Dainippon Pharma has more than 6,000 employees worldwide. Additional information about Sumitomo Dainippon Pharma is available through its corporate website at https://www.ds-pharma.com.

SUNOVION is a registered trademark of Sumitomo Dainippon Pharma Co., Ltd.

Sunovion Pharmaceuticals Inc. is a U.S. subsidiary of Sumitomo Dainippon Pharma Co., Ltd. 2020 Sunovion Pharmaceuticals Inc. All rights reserved.

For a copy of this release, visit Sunovions website at http://www.sunovion.com

References

1 Koblan, K., Kent, J., Hopkins, S., Krystal, J., Cheng, H., Goldman, R., Loebel, A., A non-D2 Binding Drug for the Treatment of Schizophrenia. New England Journal of Medicine. April 16, 2020, Vol. 382, Issue 16, p. 1497-1506. Available online: https://www.nejm.org/doi/full/10.1056/NEJMoa1911772. Accessed April 2020. 2 World Health Organization. Mental Disorders. [Internet]. Available from:https://www.who.int/news-room/fact-sheets/detail/mental-disorders. Accessed September 2018. 3 National Institute of Mental Health. Schizophrenia. [Internet]. Available from: https://www.nimh.nih.gov/health/topics/schizophrenia/index.shtml. Accessed September 2018.

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New England Journal of Medicine Publishes Pivotal Results Evaluating Sunovion's SEP-363856 for the Treatment of Schizophrenia - PharmaLive

Global Regenerative Medicine Marketwas valued US$ XX Bn in 2018 and is expected to reach US$ XX Bn by 2026, at a XX %CAGR of around 24.3% during a forecast period.

Regenerative medicine is an interdisciplinary field of medicine that is used for developing methods to grow, replace or repair diseased or damaged cells, organs, and tissues. Regenerative medicine contains the generation and use of therapeutic stem cells, tissue engineering and the production of artificial organs.

The report covers all the trends and technologies playing a major role in the growth of the regenerative medicine market over the forecast period. It highlights the drivers, restraints, and opportunities expected to influence market growth during 2019-2026.

Global Regenerative Medicine Market

Regenerative medicines are expected to have a major impact on healthcare to treat specific indications and chronic conditions. Therefore, a high prevalence of cancer, neurodegenerative, orthopedic, and other ageing-associated disorders coupled with increasing worldwide geriatric population is driving the market growth. Additionally, increasing prevalence of inheritable genetic diseases is anticipated to fuel the demand in the field of the biotechnology field. However, high treatment costs, operative inefficiency, stringent government regulations, and lack of awareness will restrict the global market for regenerative medicine.

REQUEST FOR FREE SAMPLE REPORT:https://www.maximizemarketresearch.com/request-sample/35229/

The report on global regenerative medicine market covers segments such as type, application and region. Based on application, oncology segment is estimated to witness the fastest XX% CAGR over the forecast period. Many government organizations, as well as private companies, have made high investments in cancer research and development of regenerative & advanced cell therapies. Global efforts to reduce the cancer burden is expected to support the lucrative growth of the oncology segment.North America is the dominating region in the market for regenerative medicine. The major factors promoting regenerative medicine market growth in this region are growing awareness for the use of these medicines to treat various diseases and rising funding line for developing the product line by the private and government organizations.

However, the APAC is considered to grow at a faster rate during the forecast period because of the increasing focus on research and development on regenerative medicine, various government have taken initiative to treat many diseases with the help of regenerative medicines. The report gives a recent development in the market for regenerative medicine like in 2018, Novartis AG received EU approval for one-time gene therapy Luxturna, which has been developed to restore visualization in people with rare and genetically-associated retinal disease. Additionally, in 2017, Integra LifeSciences launched its product, Integra Dermal Regeneration Template Single Layer Thin for dermal repair faults reconstruction in a one-step procedure.

The objective of the report is to present a comprehensive assessment of the market and contains thoughtful insights, facts, historical data, industry-validated market data and projections with a suitable set of assumptions and methodology. The report also helps in understanding Global Regenerative Medicine Market dynamics, structure by identifying and analyzing the market segments and project the global market size. Further, the report also focuses on the competitive analysis of key players by product, price, financial position, product portfolio, growth strategies, and regional presence. The report also provides PEST analysis, PORTERs analysis, and SWOT analysis to address the question of shareholders to prioritizing the efforts and investment shortly to the emerging segment in the Global Regenerative Medicine Market.Scope of the Global Regenerative Medicine Market

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Global Regenerative Medicine Market, By Type

Cell-Based Immunotherapy & Cell Therapy Productso Allogeneic Productso Autologous Products Tissue-Engineered Products Gene Therapy ProductsGlobal Regenerative Medicine Market, By Application

Musculoskeletal Disorders Wound Care Oncology Ocular Disorders Diabetes OtherGlobal Regenerative Medicine Market, By Region

North America Europe Asia Pacific Middle East & Africa South AmericaKey Players operating in the Global Regenerative Medicine Market

Integra LifeSciences Corporation Astellas Pharma Inc. Ocata Therapeutics, Inc. Corline Biomedical AB Cook Biotech, Inc. Bayer BV BlueRock Therapeutics AstraZeneca MedImmune F. Hoffmann-La Roche Ltd Pfizer Inc. Merck & Co., Inc. Sigma-Aldrich Co. LLC Abbott St. Jude Medical, Inc. Vericel Corporation Novartis AG Alcon GlaxoSmithKline plc. Baxter. Synovis Micro Companies Alliance Inc Amgen Inc. Eli Lilly and Company Bristol-Myers Squibb Company iPierian, Inc Nuvasive, Inc. Organogenesis, Inc. NuTech MiMedx Group, Inc. Stability, LLC. Takara Bio Inc. Caladrius Biosciences, Inc. U.S. Stem Cell, Inc. Cesca Therapeutics Osiris Therapeutics, Inc

MAJOR TOC OF THE REPORT

Chapter One: Regenerative Medicine Market Overview

Chapter Two: Manufacturers Profiles

Chapter Three: Global Regenerative Medicine Market Competition, by Players

Chapter Four: Global Regenerative Medicine Market Size by Regions

Chapter Five: North America Regenerative Medicine Revenue by Countries

Chapter Six: Europe Regenerative Medicine Revenue by Countries

Chapter Seven: Asia-Pacific Regenerative Medicine Revenue by Countries

Chapter Eight: South America Regenerative Medicine Revenue by Countries

Chapter Nine: Middle East and Africa Revenue Regenerative Medicine by Countries

Chapter Ten: Global Regenerative Medicine Market Segment by Type

Chapter Eleven: Global Regenerative Medicine Market Segment by Application

Chapter Twelve: Global Regenerative Medicine Market Size Forecast (2019-2026)

Browse Full Report with Facts and Figures of Regenerative Medicine Market Report at:https://www.maximizemarketresearch.com/market-report/global-regenerative-medicine-market/35229/

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Global Regenerative Medicine Market : Industry Analysis and Forecast (2019-2026): By Type, Application and Region. - Publicist360

China Regenerative Medicine International Limited (HKSE:8158) STOCK IN FOCUS:

Overbought and Oversold levels

The stock has RSI reading of 53.08. RSI gives an indication of the impending reversals or reaction in price of a security. RSI moves in the range of 0 and 100. So an RSI of 0 means that the stock price has fallen in all of the 14 trading days. Similarly, an RSI of 100 means that the stock price has risen in all of the 14 trading days. In technical analysis, an RSI of above 70 is considered an overbought area while an RSI of less than 30 is considered as an oversold area. RSI can be used as a leading indicator as it normally tops and bottoms ahead of the market, thereby indicating an imminent correction in the price of a security. It is pertinent to note that the levels of 70 and 30 needs to be adjusted according to the inherent volatility of the security in question.

If you are considering getting into the day trading or stock market, its a legitimate and profitable method for making a living. Every good investor knows that in order to make money on any investment, you must first understand all aspects of it, so lets look at daily change, stock price movement in some particular time frame, volatility update, performance indicators and technical analysis and analyst rating. Picking a stock is very difficult job. There are many factors to consider before choosing a right stock to invest in it. If picking stock was easy, everyone would be rich right? This piece of financial article provides a short snap of China Regenerative Medicine International Limited regarding latest trading session and presents some other indicators that can help you to support yours research about China Regenerative Medicine International Limited.

China Regenerative Medicine International Limited (HKSE:8158) stock Trading Summary:

China Regenerative Medicine International Limited (HKSE:8158) stock changed position at +1.92%% to closing price of HKD$0.265 in recent trading session. The last closing price represents the price at which the last trade occurred. The last price is also the price on which most charts are based; the chart updates with each change of the last price. The stock registered Last trading volume of 426750 shares. Daily volume is the number of shares that are traded during one trading day. High volume is an indication that a stock is actively traded, and low volume is an indication that a stock is less actively traded. Some stocks tend always to have high volume, as they are popular among day traders and investors alike. Other stocks tend always to have low volume, and arent of particular interest to short-term traders. The stock average trading capacity stands with 1.648M shares and relative volume is now at 0.26 .

China Regenerative Medicine International Limited (HKSE:8158) Stock Price Movement in past 50 Days period and 52-Week period

China Regenerative Medicine International Limited stock demonstrated 12-month low at HKD$0-39.62% and unveiled a 12-month high of HKD$1+239.62%. Prices of commodities, securities and stocks fluctuate frequently, recording highest and lowest figures at different points of time in the market. A figure recorded as the highest/lowest price of the security, bond or stock over the period of past 52 weeks is generally referred to as its 52-week high/ low. It is an important parameter for investors (as they compare the current trading price of the stocks and bonds to the highest/lowest prices they have reached in the past 52 weeks) in making investment decisions. It also plays an important role in determination of the predicted future prices of the stock.

China Regenerative Medicine International Limited (HKSE:8158) Stock Past Performance

China Regenerative Medicine International Limited stock revealed 0.06% return for the recent month and disclosed 0.1522% return in 3-month period. The stock grabbed -0.9732% return over five years and -0.47% return in yearly time period. Past performance shows you the funds track record, but do remember that past performance is not an indication of future performance. Read the historical performance of the stock critically and make sure to take into account both long- and short-term performance. Past performance is just one piece of the puzzle when evaluating investments. Understanding how performance fits in with your overall investing strategy and what else should be considered can keep you from developing tunnel vision.

Volatility in Focus:

The stock unfolded Volatility or average true range percent (ATRP 14) at 0.0507%. Volatility is a rate at which the price of a security increases or decreases for a given set of returns. Average true range percent (ATRP) measures volatility on a relative level. This is opposed to the ATR, which measures volatility on an absolute level. ATRP allows securities to be compared whereas ATR does not. That means lower-priced stocks wont necessarily have lower ATR values than higher priced stocks.

Beta factor is now at 0.86. BETA indicates whether a stock is more or less volatile than the market as a whole. A stock that has a beta score higher than 1 means that volatility is high, while less than 1 means that volatility is low.

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Hot Stock in the Spotlight:: China Regenerative Medicine International Limited (HKSE:8158) - Investor Welcome

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Complications arising from these illnesses can become serious, says Dr. Suhyun An (drsuhyunan.com), an expert on regenerative medicine and co-author of Demystifying Stem Cells: A Real-Life Approach To Regenerative Medicine.

An says there are ways to prevent the symptoms from reaching that serious point. To feel better and get back on your feet, she recommends numerous natural cold and flu remedies to alleviate your symptoms:

Vitamin C. Some studies indicate that vitamin C can shorten the lifespan of a cold and boost your immune system. The best way to get it is through your diet; the fresher the food, the better, An says. Oranges, limes, lemons, grapefruits, leafy greens, and bell peppers are all good sources of vitamin C. Be careful with supplements because they can lead to upset stomach and kidney stones.

Honey. Honey has natural antiviral and antimicrobial properties. Drinking honey in tea with lemon can ease sore throat pain, An says. Research suggests that honey is an effective cough suppressant, too. Honey often contains Clostridium bacteria, so never give honey to a child younger than 1-year-old because infants immune systems arent able to fight them off.

Chicken soup. This popular cold and flu remedy helps because hot liquids reduce mucus buildup and keep you hydrated. Chicken soup, in particular, has anti-inflammatory properties, which help reduce a colds unpleasant side effects, An says. Keep some in the freezer or even canned for flu season. Its quick to prepare that way and soothing to eat.

Aromas. When you have congestion from the flu, applying camphor or menthol salve around your nose can help break up mucus, An says. Aromatherapy oils, such as peppermint and eucalyptus, can have a similar effect. Also, vapor rub can reduce cold symptoms, especially in children older than 2 years. It helps open air passages to combat congestion, reduce coughing, and improve sleep. Its a good alternative to over-the-counter cold medicines in young children because of unwanted side effects.

Probiotics. These are friendly bacteria and yeast found in the body, some foods, and supplements. They can help keep your gut and immune system healthy, and they may reduce your chance of getting sick with an upper respiratory infection, An says. For a delicious and nutritious source of helpful bacteria, include probiotic yogurt in your diet.

Colds and the flu are threats to us every year, but they dont have to get us down for long, An says. Natural home remedies can reduce symptoms so you can be more comfortable and get the rest you need to get better faster.

Dr. Suhyun An is the clinic director at Campbell Medical Group in Houston and an expert on regenerative medicine.

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COLUMN Worried about your immune system? Try these 5 natural remedies - Body aches fever chills and nasal congestion common symptoms of the flu can...