StemCell Therapy

Bronze Age skull in situ in the Tollense Valley. Credit: Stefan Sauer / Tollense Valley Project

The ability for humans to digest milk as adults has altered our dietary habits and societies for centuries. But when and how that ability known as lactase persistence or lactose tolerance occurred and became established is up for debate. By testing the genetic material from the bones of people who died during a Bronze Age battle around 1,200 BC, an international team of scientists including Krishna Veeramah, PhD, of Stony Brook University, suggest that lactase persistence spread throughout Central Europe in only a few thousand years, an extremely fast transformation compared to most evolutionary changes seen in humans. Their findings are published today (September 3, 2020) in Current Biology.

Various bones at a Bronze Age battle excavation site, some of which were genetically tested to determine the presence of the lactase-persistent gene. Credit: Stefan Sauer / Tollense Valley Project

Despite the prominence of milk drinking in Europe and North American today, approximately two-thirds of the worlds population remains lactose intolerant. Generally, no mammal digests milk as an adult, which is why for example people should not give adult cat or dog pets milk. However, a subset of humans have a genetic mutation that enables the enzyme lactase to digest the lactose sugar found in milk throughout an individuals lifetime. Many of these people are from Central or Northern Europe.

The battle occurred on the banks of the Tollense, a river in present-day Germany, and is the most significant that we know about from Bronze Age Europe, probably consisting of about 4,000 warriors, almost a quarter of which died during the fighting. Despite being more than three thousand years old, the researchers were able to sequence DNA from some of the bone fragments recovered from the battle site.

Veeramah, Associate Professor in the Department of Ecology and Evolution in the College of Arts and Sciences, led part of the research that involved analyzing how the overall genetic ancestry of the battlefield population compared to other modern and ancient populations, and then compared the frequency of the lactase-persistent allele to other modern and ancient populations, particularly medieval European populations.

Archaeologists have been systematically searching a section along the Tollense river for more than 10 years. Credit: Stefan Sauer / Tollense Valley Project

The research team, led by Joachim Burger and colleagues at Johannes Gutenberg University Mainz (JGU), found that despite the battle occurring more than 4,000 years after the introduction of agriculture in Europe which in part would have involved the consumption of dairy from early cattle, goats and sheep domesticates only one in eight of the warriors had a genetic variant that enabled them to break down lactose.

When we look at other European genetic data from the early Medieval period less than 2,000 years later, we find that more than 60 percent of individuals had the ability to drink milk as adults, close to what we observe in modern Central European countries, which ranges from 70 to 90 percent said Veeramah. This is actually an incredibly fast rate of change for the gene that controls milk digestion. It appears that by simply possessing this one genetic change, past European individuals with the ability to digest lactose had a six percent greater chance of producing children than those who could not. This is the strongest evidence we have for positive natural selection in humans.

Joachim Burger of JGU, lead author on the study, added that there still is not definitive answer to the question: Why did being able to digest the sugar in milk after infancy provide such a big evolutionary advantage?

With milk being a high-energy, relatively uncontaminated drink, its ingestion may have provided greater chances of survival during food shortages or when supplies of drinking water may have been contaminated, explained Burger.

Reference: Low Prevalence of Lactase Persistence in Bronze Age Europe Indicates Ongoing Strong Selection over the Last 3,000 Years by Joachim Burger, Vivian Link, Jens Blcher, Anna Schulz, Christian Sell, Zo Pochon, Yoan Diekmann, Aleksandra egarac, Zuzana Hofmanov, Laura Winkelbach, Carlos S. Reyna-Blanco, Vanessa Bieker, Jrg Orschiedt, Ute Brinker, Amelie Scheu, Christoph Leuenberger, Thomas S. Bertino, Ruth Bollongino, Gundula Lidke, Sofija Stefanovi, Detlef Jantzen, Elke Kaiser, Thomas Terberger, Mark G. Thomas, Krishna R. Veeramah and Daniel Wegmann, 3 September 2020, Current Biology.DOI: 10.1016/j.cub.2020.08.033

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Genetic Analysis of Bones From a Bronze Age Battle Reveal Lactose Tolerance Quickly Spread Throughout Europe - SciTechDaily

The University Hospital Heidelberg is one of the major healthcare centers in Germany. Our objective is the development of innovative diagnostics and therapies as well as their quick implementation for the patient. With about 10,700 employees in more than 50 specialized clinical departments with almost 2,000 beds, about 80,000 patients in part-time and full-time inpatient treatment as well as 1,000,000 patients in ambulant treatment are medicated each year.

JobID: P0025V280

Location: Institut of Human Genetics, INF 366, 69120 HeidelbergContract: 2 years with extension possibilities, begin as soon as possibleSalary: Competitive, subject to skills and experience

The newly created Nephrogenetics unit headed by Matias Simons is looking for an enthusiastic postdoc to join our research group at the Institute of Human Genetics of the University Hospital Heidelberg. The general interest of the lab is in the molecular mechanisms underlying hereditary kidney and metabolic diseases. Most of these diseases are caused by single-gene defects and thereby offer unique opportunities to decipher fundamental regulatory pathways of human physiology and to develop targeted diagnostic and therapeutic options. Recent publications include Marchesin et al, Cell Rep 2020; Bedin et al, J Clin Invest 2019; Goncalves et al, PloS Genetics 2018; Simons, JASN 2018; Rujano et al, J Exp Med 2017; Trepiccione et al, JASN 2016; Gleixner et al, Cell Rep 2014. We combine human genetics with several experimental approaches, including fly and mouse genetics, cell culture, microscopy and biochemistry. For more info on the lab see http://www.simons-lab.de.

We offer an exciting project aimed at exploring the role of random monoallelic expression in renal development and homeostasis. For this project, we invite applications from individuals with a solid background in molecular cell biology. Prior experience with stem cells (e.g. mouse ESCs), organoids, single cell RNA-seq, epigenetics and kidney research is an advantage but not a prerequisite. The projects will be carried out in a stimulating work environment with scientific collaborations within the institute, across the Heidelberg life science community (e.g. EMBL, DKFZ) and worldwide.

The successful applicant will have good communication and organisational skills and a PhD in a relevant area (or be in the final stages of completion). We also invite applications from research-oriented MDs. Candidates are expected to be highly motivated and to work independently with a strong work ethic. As we are an international lab, profictiency in English language is a requirement. Applications including a cover letter, a detailed CV including a publication list and contacts of up to three referees should be sent as soon as possible to matias.simons@med.uni-heidelberg.de

The University Hospital Heidelberg offers:

http://www.klinikum.uni-heidelberg.de/karriere

We stand for equal opportunities. People with disabilities are given priority with the same suitability. The university hospital aims at a general increase in the proportion of women in all areas and positions where women are underrepresented. Qualified women are therefore particularly encouraged to apply.

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ERC-funded postdoctoral position at the Institut of Human Genetics, - Nature.com

The Alliance Review

(NAPSI)Social isolation during the pandemic may pose a mental health threat for those already at risk for COVID-19people over age 65.

As doctors treat more senior patients for depression, an increasingly popular genetic test may inform their treatment decisions. The GeneSight test (www.genesight.com) provides information about how your genes may impact how you metabolize and respond to certain depression medications.

Innovative solutions for mental health conditions are important. As the pandemic and its resulting isolation wears on, many are struggling with their mental health. According to the Centers for Disease Control and Prevention, loneliness can be associated with higher rates of depression.

When I first experienced depression, it happened all of a sudden, shared Doreen, a wife, mother of three grown children, and retiree. It was like a cloud happened in my head.

Symptoms of depression can include changes in sleep or eating patterns, decreased energy, difficulty concentrating or a lack of motivation.

Doreen saw her doctor, who prescribed a depression medication but it didnt alleviate her symptoms.

I began to see one doctor, then another, to help deal with my depression, said Doreen. Her doctors tried many, many different medications and none seemed to work. Finally, my heart doctor said, Doreen, Ive heard about this gene test, I think it might help you.

Her doctor was referring to the GeneSight test.

The test is a simple cheek swab, ordered by a healthcare provider who can prescribe medications. A patient can take the test at home or in the doctors office.

Using a patients unique DNA, the GeneSight test informs doctors about potential gene-drug interactions. The report provides information about which depression medications may require dose adjustments, may be less likely to work, or may have an increased risk of side effects based on a patients genetic makeup.

The GeneSight test helped Doreens doctor to make an informed treatment decision; she was prescribed a new medication.

Thats when my life started to change. I got back to smiling, being happy and laughing again. I got back to being me, Doreen said.

Post-pandemic life will likely never be the same. If depression is one of the unanticipated consequences, treatment is important.

People struggling with depression can ask their doctor about the GeneSight test. To learn more, visit http://www.GeneSight.com.

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Pandemic Depression: Genetic Insight May Help Treatment - The-review

The consumer genetics startup, which claims it can tell customers what kind of foods they should eat and whether theyre predisposed to intelligence based on their DNA, has secured some of the biggest coronavirus testing contracts in the country.

A Boston consumer genetics company that has batted away former employees accusations of shoddy practices since at least 2019 is now under investigation by the state Department of Public Health for logging hundreds of false positive coronavirus test results.

The company, Orig3n, has halted COVID-19 testing in the state. A company spokesman said the false positives were due to "human error" in processing the tests.

In August, after learning about the Massachusetts investigation, North Carolina issued a stop order for its coronavirus testing contract with Orig3n.

The consumer genetics startup, which claims it can tell customers what kind of foods they should eat and whether theyre predisposed to intelligence based on their DNA, has secured some of the biggest coronavirus testing contracts in the country.

According to an Orig3n spokesman, the company continues to offer COVID-19 testing elsewhere in the U.S.

So far, the Massachusetts DPH has found Orig3n sent out more than 300 COVID-19 tests wrongly classified as positive in Massachusetts, a number that could increase as DPH staff continue investigating. Orig3n claims the company isnt aware of any additional false positives. According to a Harvard epidemiologist and lab director, false negatives are far more difficult to discover, because most tests come back as negative.

Ted Owens, CEO at North Hills Pines Edge skilled nursing facility in Needham, one of roughly 60 long-term care facilities that used Orig3n test services, said in an Aug. 11 bulletin to residents and staff that Orig3n returned a total of 19 false positives to the nursing home.

The numbers didnt seem credible to Owens, but Pines Edge began immediately to take actions based on the working assumption that we needed to treat these results as correct.

It turned out that several other skilled nursing facilities also showed an unusual spike in positive cases last week, and oddly enough, all these facilities had used the same testing vendor, Owens continued. This caught the attention of the epidemiologists at Mass DPH, who intervened and instructed the vendor to re-test the samples."

Upon retesting, all of the positive tests were found to be negative.

The spike in cases which turned out to be false positives caused panic in Needham. They came as the school district made plans to return to in-person learning, and a public health nurse for the town was asked to appear before the Select Board.

Needham public health nurse Tiffany Zike told the board on Aug. 18 that a number of coronavirus cases reported in July were considered false cases that were revoked due to the lab having an issue.

$25,000 wire transfer

In early May, nursing homes throughout Massachusetts were looking for a miracle.

The DPH had ordered long-term care facilities coping with severe coronavirus outbreaks to test 90% of residents and staff for COVID-19 by May 25 in order to qualify for a portion of $130 million in relief funding offered by the state.

Many nursing homes struggled to meet the deadline because of a shortage of COVID-19 tests. The National Guard was testing nursing home residents and staff on behalf of the state, but demand was high.

When Ron Doty got a memo from the Massachusetts Senior Care Association on May 6 offering Orig3n as a turnkey mobile testing option, he immediately reached out to the company.

Doty, administrator at Marlborough Hills Rehabilitation & Health Care Center in Marlborough, wired $25,000 to Orig3n. The next day, he received 250 COVID-19 test kits from the company.

Two months later, Orig3n was asked to suspend COVID-19 testing in Massachusetts, which it did on Aug. 8. Staff at the DPH noticed the lab was reporting an unusually high rate of positive tests, prompting the agency to investigate, according to a DPH spokesperson.

The state DPH declined to identify which nursing homes used Orig3ns testing services, citing the ongoing investigation.

Tony Plohoros, Orig3ns spokesman, said the lab is now working with state health officials to correct problems in its Boston lab, which has ceased processing coronavirus samples but continues to process consumer genetic profiles.

While it remains unclear if the federal government has taken action to halt use of Orig3ns COVID-19 testing services in other parts of the country, as North Carolina did, concerns about Orig3n hadnt yet reached a health care supply company in Ohio as of this week. That company, Mason, Ohio-based Link-age Solutions, is still working with Orig3n to provide coronavirus tests to long-term care facilities nationwide.

Patrick Schwartz, a spokesman for Link-age Solutions, said Thursday that the company was unaware Orig3n was asked to cease coronavirus testing in Massachusetts.

One of the highest accuracy ratings in the market

Orig3n received an emergency authorization to conduct COVID-19 testing from the Food and Drug Administration in April.

The same month, the company received a federal Paycheck Protection Program loan valued between $350,000 and $1 million from Silicon Valley Bank, according to U.S. Treasury data.

Since getting the FDA approval, Orig3n has provided testing services to The New England Power Generators Association, Bostons homeless population, a boarding school in Virginia and other public and private entities.

In late June, Link-age Solutions, which helps long-term care facilities nationwide obtain supplies ranging from pharmaceuticals to office supplies, issued a press release touting Orig3ns breakthrough testing method as having one of the highest accuracy ratings in the market.

In partnering with Orig3n, Link-age could offer in-demand coronavirus tests to its members at a reduced cost, according to the press release. Results would be returned less than 36 hours after specimens arrived at the lab, the release said.

The lab boasts output capabilities of 6,000 and up to 12,000 tests per day, and will offer billing to Medicare where appropriate, the press release stated. Reporters questions to the Centers for Medicare & Medicaid Services have gone unanswered.

Schwartz, the Link-age spokeman, said Thursday his company continues to offer COVID-19 testing services performed by Orig3n, and that feedback about Orig3ns tests from its customers has been positive.

Company flagged in the past

Orig3n lists its office location as the third floor of 27 Drydock Ave. in the heart of Bostons Seaport neighborhood. Until August, thats where the company processed its coronavirus tests.

Before it got into the coronavirus business, Orig3n billed itself as a consumer genetics pioneer, carving a path toward a future of wellness and health through the use of diagnostics, genetics and biotechnology.

The company, founded in 2014, offers tests ranging in cost from $29 to $298 that are supposed to help people learn what kinds of food, exercise and beauty products would work best for their genetic profiles, and even whether they are genetically predisposed to so-called superhero traits including intelligence and strength, according to Bloomberg Businessweek.

A former Orig3n employee who spoke to Gannett New England reporters on the condition of anonymity because of a nondisclosure agreement with the company said the number one complaint received by customer service was genetic profile tests not being returned to customers. The employee, who left the company pre-pandemic, didnt think the company could handle both genetic profile testing and coronavirus testing.

Unless things drastically changed since I have left, not even testing, just bandwidth-wise, they were already kind of drowning when I left, the employee said.

Despite its startup status, Orig3n quickly gained prominence partly through securing big-name partnerships, including one with the NFLs Baltimore Ravens.

In September 2017, the Ravens linked up with Orig3n for an event called DNA Day. Roughly 70,000 Ravens fans were set to pour into the teams stadium, where they could have picked up a free genetic testing kit.

The event never happened. The Ravens postponed it days before federal health officials told The Baltimore Sun they were working to determine whether any of the testing being offered by Orig3n is subject to the requirements of the Clinical Laboratory Improvement Amendments of 1988.

The federal regulatory standards apply to labs testing human samples in the United States, and are intended to ensure accuracy, effectiveness and reliability.

About a year after DNA Day was scrapped, 17 former Orig3n employees criticized the company in Bloomberg Businessweek, alleging it habitually cut corners, tampered with or fabricated results, and failed to meet basic scientific standards.

Marketing, not science, the employees said, was the companys priority.

Press releases put out by Orig3n throughout the pandemic show the company was eager to publicize contracts with respected institutions, both public and private.

On May 12, the company announced what it called a comprehensive solution to enable COVID-19 testing for Massachusetts nursing home residents.

In the press release, the company said it sought to become the partner of choice for coordinating and providing COVID-19 testing for defined populations beyond long-term care residents and employees, including private employers, schools, government agencies, and cities and states.

The nursing home program is one of many applications for Orig3ns fully-integrated solution, the press release said.

What went wrong?

Doty, the Marlborough nursing home administrator, would not have known about Orig3n if not for the May 6 memo from Massachusetts Senior Care Association, an organization many nursing homes relied on during the viruss spring surge in the state to interpret complex and shifting guidance from the DPH.

Massachusetts Senior Care Association President Tara Gregorio said in a statement that her organization essentially serves as a messenger for its members, and that it relies on governmental agencies to vet labs like Orig3n.

"Throughout the pandemic, MSCA has passed along lists of government approved COVID-19 PCR testing labs options available to our members, Gregorio wrote. We must rely, as all providers do, on the licensing process to ensure legitimacy and accuracy of these labs."

The FDA, which gave Orig3n emergency authorization to conduct coronavirus testing last spring, has not yet responded to Gannett New England reporters seeking comment.

According to a Massachusetts DPH spokesman, Orig3n told the agency after it was contacted by DPH that errors in testing occurred because of a broken vial or contaminated plate during final processing, an explanation DPH investigators are now trying to confirm.

In an email to Gannett New England reporters on Friday, Plohoros, Orig3ns spokesman, said human error at the beginning of the laboratory testing process caused a pre-extraction reagent that was used in the affected batch tests to become contaminated.

In an Aug. 18 press conference, Massachusetts Secretary of Health and Human Services Marylou Sudders said erroneous results from Orig3n affected the number of COVID-19 cases reported in Fall River and Taunton.

The positive test rates for that three-day period for that one lab just seemed high, and so (we) went back, and the lab stopped processing, they're still not processing any tests, Sudders said, adding that DPH staff was analyzing tests processed prior to the discovery to make sure the issue was, as Orig3n told the DPH, a one-time problem rather than a more structural issue.

Dr. Michael Mina is an assistant professor of epidemiology at Harvard T. H. Chan School of Public Health who has experience running laboratories that perform PCR testing.

Mina says a lab that processes 6,000 to 12,000 PCR coronavirus tests a day as Orig3n has said it does would need to be run with what he called extreme quality control measures.

It requires an amazing amount of concentration and care to really ensure you're not getting contamination or any number of other problems that can happen, he said. If this was an easy (test), I would have said, sure, any lab can do it but this particular (test) ... it really is a finicky test. You have to be extremely careful about how you're doing it, and that means you need a lot of quality controls. You need to be a really diligent lab.

Mina, who stressed he has no knowledge of Orig3n other than circulating allegations that the company had previously been investigated, said when a mistake like the kind Orig3n described occurs, staff should immediately stop processing, sterilize the area and alert any affected patients and health departments.

The fact that the Massachusetts DPH noticed the problem and not Orig3n is a problem, Mina said.

That shows in general that the quality control wasn't being maintained, he said, adding that performing intense quality control checks multiple times daily is a core tenet of running any lab, especially a high-complexity clinical lab. And if we're giving them the benefit of the doubt, they didn't know that there was a problem because otherwise it's just nefarious.

Mina said that a professionally run lab would likely have caught the mistake, and alerted the state DPH immediately.

Part of the reason for that is simply a motive to care for the patient, who will likely make important decisions about their own behavior based on the test result they receive, which in turn affect other people.

At Brigham, for example, where I was one of the medical directors, of course people feel embarrassed (about making a mistake), but there's this strong culture where people recognize that their embarrassment is not worth a patient's hardship, Mina said. That's one thing that really, I think, lacks a little bit when we move into industry laboratories running clinical tests. That same spirit of honesty ... might not exist everywhere.

While mistakes at labs are common, Mina said, they're also commonly fixed and they don't usually require an investigation.

Mina said that the U.S. did need to increase its capacity to process coronavirus tests this spring, but labs, especially ones new to the medical diagnostics space, as Orig3n is, need to be monitored closely.

It's just important to keep all these things in check, Mina said. The frenzy to do coronavirus testing has been so extreme. I don't think labs should be immediately shut down for mistakes, but we have to remain vigilant to ensure that all the testing that is being done is up to the highest standards.

Trevor Ballantyne and Jeannette Hinkle are reporters for Gannett New England.

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Massachusetts startups COVID-19 testing halted as hundreds of false results probed - Enterprise News

Global Genetic Ancestry Testing Market Report from AMA Research highlights deep analysis on market characteristics, sizing, estimates and growth by segmentation, regional breakdowns& country along with competitive landscape, players market shares, and strategies that are key in the market. The exploration provides a 360 view and insights, highlighting major outcomes of the industry. These insights help the business decision-makers to formulate better business plans and make informed decisions to improved profitability. In addition, the study helps venture or private players in understanding the companies in more detail to make better informed decisions.

Major Players in This Report Include,

MyHeritage (Israel), Laboratory Corporation (United States), Myriad Genetics, Inc. (United States), Ancestry.com LLC (United States), Quest Diagnostics (United States), Gene By Gene (United States), DNA Diagnostics Center, Inc. (United States), Invitae (United States), IntelliGenetics (United States) and Ambry Genetics Corp. (United States)

Free Sample Report + All Related Graphs & Charts @: https://www.advancemarketanalytics.com/sample-report/125027-global-genetic-ancestry-testing-market

Definition

Genetic ancestry testing is a way for people interested in family history to go beyond what they can learn from relatives or from historical documentation. It gives clues about where a persons ancestors might have come from and about relationships between families.

Global Genetic Ancestry Testing Market Report offers a detailed overview of this market and discusses the dominant factors affecting the growth of the market. The impact of Porters five armies on the market over the next few years has been discussed for a long time in this study. We will also forecast global market size and market outlook over the next few years.

Types of Products, Applications and Global Genetic Ancestry Testing Market Report Geographical Scope taken as the Main Parameter for Market Analysis. This Research Report Conducts an assessment of the industry chain supporting this market. It also provides accurate information on various aspects of this market, such as production capacity, available production capacity utilization, industrial policies affecting the manufacturing chain and market growth.

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Market Drivers

Market Trend

Restraints

Opportunities

In this research study, the prime factors that are impelling the growth of the Global Genetic Ancestry Testing market report have been studied thoroughly in a bid to estimate the overall value and the size of this market by the end of the forecast period. The impact of the driving forces, limitations, challenges, and opportunities has been examined extensively. The key trends that manage the interest of the customers have also been interpreted accurately for the benefit of the readers.

The Genetic Ancestry Testing market study is being classified by Type, Applicationsand major geographies with country level break-up that includes South America (Brazil, Argentina, Rest of South America), Asia Pacific (China, Japan, India, South Korea, Taiwan, Australia, Rest of Asia-Pacific), Europe (Germany, France, Italy, United Kingdom, Netherlands, Rest of Europe), MEA (Middle East, Africa), North America (United States, Canada, Mexico).

The Global Genetic Ancestry Testing is segmented by following Product Types:

by Type (Y Chromosome Testing, Mitochondrial DNA Testing, Single Nucleotide Polymorphism Testing), Service (Online Testing, Offline Testing)

.

The report concludes with in-depth details on the business operations and financial structure of leading vendors in the Global Genetic Ancestry Testing market report, Overview of Key trends in the past and present are in reports that are reported to be beneficial for companies looking for venture businesses in this market. Information about the various marketing channels and well-known distributors in this market was also provided here. This study serves as a rich guide for established players and new players in this market.

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Current Scenario Analysis for Decision Framework

Key Strategic Developments in Genetic Ancestry Testing Market:

The research includes the key strategic activities such as Research & Development (R&D) initiatives, Merger & Acquisition (M&A) completed, agreements, new launches, collaborations, partnerships & (JV) Joint ventures, and regional growth of the key competitors operating in the market at global and regional scale to overcome current slowdown due to COVID-19.

Key Market Features in Global Genetic Ancestry Testing Market

The report highlights Genetic Ancestry Testing market features, including revenue size, weighted average regional price, capacity utilization rate, production rate, gross margins, consumption, import & export, demand & supply, cost bench-marking in Genetic Ancestry Testing market share and annualized growth rate (Y-o-Y) and Periodic CAGR.

Extracts from Table of Contents

Global Genetic Ancestry Testing Market Research Report

Chapter 1 Global Genetic Ancestry Testing Market Overview

Chapter 2 Global Economic Impact on Industry

Chapter 3 Global Market Competition by Manufacturers

Chapter 4 Global Revenue (Value, Volume*) by Region

Chapter 5 Global Supplies (Production), Consumption, Export, Import by Regions

Chapter 6 Global Revenue (Value, Volume*), Price* Trend by Type

Chapter 7 Global Market Analysis by Application

.continued

This report also analyzes the regulatory framework of the Global Markets Genetic Ancestry Testing Market Report to inform stakeholders about the various norms, regulations, this can have an impact. It also collects in-depth information from the detailed primary and secondary research techniques analyzed using the most efficient analysis tools. Based on the statistics gained from this systematic study, market research provides estimates for market participants and readers.

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Genetic Ancestry Testing Market is expected to double its Market Size in Upcoming Years - Scientect

Written by Parthasarathi Biswas | Pune | September 3, 2020 11:14:01 pmTo encourage farmers, the programme marketed the produce under the brand, Farming Monk, in urban areas for a premium. (Representational)

SIX YEARS after they took up the work of conserving local or traditional (better known as landrace) varieties of rice, sorghum and vegetables, Pune-headquartered BAIF Development and Research Foundation (BDRF) now has plans to take their work to a molecular level. Along with National Institute for Abiotic Stress Management in Baramati, BDRF will try to identify genetic traits that allow these varieties to develop better climate resilience than more commonly grown commercial varieties.

Since January 2014, BDRF has started Maharashtra Gene Bank Programme for Conservation, Management and Revival of Local Resources.

Under the sponsorship of Rajiv Gandhi Science & Technology Commission of the state government, this project has been involved in preserving landrace varieties of crops like rice, millet, sorghum, maize, hyacinth bean, cowpea as well as indigenous livestock varieties for the past six years.

Vitthal Kauthale, thematic programme executive, BDRF, said the project saw both in situ (on spot) and ex situ conservation of landrace varieties. The project, which is to end by September 30, has so far seen conservation of 350 varieties of different crops in 25 in situ conservation at six clusters.

Kauthale said landraces, at present, are under threat with farmers opting for more commonly available commercial varieties. In fact, some of the rice varieties that the programme managed to salvage from near extinction, were now found only in tribal regions of Maharashtra, he said.

He also said these land varieties had better climate resilience than commercial varieties and could withstand heavy rainfall and other extreme climatic events.

During the last six years of the project, BDRF partnered with the local community for preserving local varieties. The process involves purification, trait identification, and then propagation of the variety at the farmer level. Last year, the project recorded production of 13.2 tonnes of worthy landraces of six focused races and availability of quality seeds through village-level community seed banks at six clusters and one central seed bank.

The project has involved self-help groups conserve and propagate crops. To encourage farmers, the programme marketed the produce under the brand, Farming Monk, in urban areas for a premium.

As the project comes to an end, BDRF has plans to upscale the project in a more scientific manner. To date, we were protecting and preserving landraces on field. Now, we wish to go to the molecular level and try to identify genetics that provide resilience to these varieties, Kauthale said.

He added that the collaboration with the Baramati institute aimed at doing the same, and once this was identified, the genes could be used to impart the same characteristic to commercial crops.

One of the major problems faced in conservation of landraces is the lack of any legal identity. The Seed Act, which governs the business of seeds, does not mention landraces and, thus, such seeds cannot be sold commercially. The BDRF has plans to take up policy-level intervention to allow the seeds to be traded.

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BDRF, Baramati institute to identify genetic traits of landrace varieties of crops - The Indian Express

While genetics can play a significant role, the picture is much bigger.

If a man has type 1 diabetes, there is a 1 in 17 chance that his child may also get it. The oddsreduceto 1 in 25 if the woman has it, and the child is born before she is 25. Type 2 diabetes has astronger linkto genetics than type 1. Genes also playsome rolein conditions like hypertension and heart ailments. And just like these illnesses, mental health issues also have some degree of heritability. However, the stigma associated with mental health makes the heredity and its implications more difficult to navigate.

Recently, actor Rhea Chakraborty said in an interview that late actor Sushant Singh Rajputs mother had lived with depression. Sushant, who was found dead in his Mumbai apartment in June, reportedly by suicide, was living with mental health issues as well. In the aftermath of the incident, there have been discussions on how Sushants mental health struggles could have been hereditary. But what do we really know about the link between genes and psychiatric disorders?

There have been numerous studies in the past and ongoing to study these links. Astudyby Consortium on the Genetics of Schizophreniapinned the heredity of schizophrenia at 31% to 44% in nuclear and extended families respectively. When bipolar disorder was included in this, the heritability increased to 37% in nuclear families. And when it came to depression, in the same study, the heritability dropped to 34% in nuclear families and 20% in extended families.

Otherstudiessay that the chances of a person developing schizophrenia if a biological parent has the condition are 13 in 100, and for bipolar disorder, its around 30 in 100. Studies have also been done on identical twins, and have found that if one sibling has schizophrenia, theres a 40-50% chance the other will develop it, because they share the same genetic makeup. Alzheimers dementia is another disease known forhigh heritability.

Dr Sanjeev Jain, officer-in-charge of the Molecular Genetics laboratory and a professor of Psychiatry at the National Institute of Mental Health Sciences, (NIMHANS) in Bengaluru, points out that most things including looks are inherited from biological parents. Mental illness is not very different that way. The only thing is that we have not been able to figure out the precise mechanism by which the causal genes get triggered. Besides, people tend to forget that if there is a 10% chance you will develop a mental health condition due to heredity, there is also a 90% chance that you wont. Till date, we have not been able to predict mental illness, because it does not only depend on the genes, he says.

Dr Sanjeev has been involved in many research and molecular diagnostics projects on neuropsychiatric disorders including Obsessive Compulsive Disorder (OCD), alcoholism, dementia and schizophrenia for several years. He, along with his colleague, Dr Biju Viswanath, Associate Professor of Psychiatry at NIMHANS, are conducting a study Accelerator program for Discovery in Brain disorders using Stem cells(ADBS) using clinicalinvestigations, modern human genetics, and stem cell technology" at NIMHANS. The study has been on since 2016.

Dr Biju says that while there's a 60-70% risk of developing a psychiatric illness contributedby genes, there are several other factors that cannot be discounted. Dr Hema Tharoor, a psychiatrist associated with Chennai-based Schizophrenia Research Foundation (SCARF), points out that it is ultimately the gene-environment interaction that determines whether a person could develop a mental health issue.

There are studies, for instance, that look at siblings wherein one parent had schizophrenia but only one child developed it, and the other two did not. And its not just sociologicalfactors that playa major role in determining ones mental health, it is also things like the antenatal and postnatal care of the mother, low birth weight, infections during pregnancy, that determine the risk of developing these disorders in the persons life too, she explains.

One 2011study, for instance, found that the risk for schizophrenia increased with certain obstetric complications, famines, migrant status, and advanced paternal age. Severe pregnancy and perinatal complications also accounted for environmental risks.

Further, Dr Sanjeev points out, its very difficult to separate genetics and culture. At any point of time, you are expressing only a third of your genes. Different genes will express themselves at different points of time. Only when that expression crosses a threshold does it become a disease.

Besides, we simply dont know all the genes that contribute to the risk of developing a psychiatric disorder or illness. In the case of Alzheimers, studies haveimplicated215 potential causative genes. However, the study by the Psychiatric Genomics Consortium said that these only explain a small proportion of genetic variance, meaning that yet undiscovered genes remain. This is the case with other mental health issues and psychiatric disorders as well.

Even so, experts say it is not necessary that everyone who carries the risk increasing genes will develop the illness its just that the genes could increase the susceptibility of an individual to getting it, and the trigger threshold for the onset could be lower. So, for instance, if someone is at a higher risk to develop OCD due to heredity, and they have also been through trauma in childhood, it could cause early onset. But its also possible that they do not develop it at all, depending on the other factors, Dr Biju says.

Several illnesses like breast cancer and leukaemia have been proven to have a high heredity factor. In some cases, gene therapies have been devised to correct or replace certain genes that could cause some illnesses. However, this is not the case with mental illnesses. The study of the brain and mind is harder because you cant just do a biopsy of the brain, says Dr Sanjeev. However, the advantage to figuring out the genomic links to mental health is that once we know the cause, we can have better drugs to treat them. Most of the ones we use now are decades old.

Dr Biju similarly says, As a doctor, you want to see your patients health improve. Say, 50% of the patients get better with psychiatric medication, but the remaining struggle. But we do not know why the medication is not working. So, if we can understand how the illness or disorder originates by identifying the genes, you can identify the mechanisms; and then we can move to more effectivetreatments.

Dr Abhishek ML, a psychiatrist and a research faculty at Bengaluru-based Indian Institute of Science (IISc), says that another hope in studying the heredity of mental health issues is early preventability. Dr Hema adds, If we can establish the endophenotypes (the neurobehavioral traits that quantify genetic susceptibility to developing a psychiatric disorder), then it becomes a preventable risk. Special care can be taken then in, say, antenatal or postnatal care.

However, Dr Abhishek cautions that this sort of technology should be accompanied by destigmatising mental health, lest it leads to profiling of persons living with certain mental health conditions and impinging of their rights.

Read more:
Understanding mental health and its heredity: What experts know so far - The News Minute

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Four aging dams on the Klamath River are coming down. Their completion between 1921 and 1964 brought hydroelectric power to Northern California. It also blocked hundreds of kilometers of fish habitat, causing chinook salmon to effectively disappear from the upper river basin. But the removal of dams is no guarantee the fish will return, so a team of wildlife researchers hopes it can coax the fish to repopulate the river by exploiting a new discovery about salmon genetics.

The Klamath was once the third-largest salmon-producing river in the United States, and its fish are still prized by Indigenous tribes that live along its winding path. In the Klamath, as in many other rivers, chinook salmon come in two main types: spring-run and fall-run. Spring-run fish start their migration from the rivers estuary four to six months before their fall-run cousins, and their return spawning run takes them farther up the river. Over time, however, human activities including mining, agriculture, and dam construction all but swept spring-run fish from the upper Klamath. Today, only the fall run of chinook salmon is large enough to support fishing.

Though dam removal has yet to beginthat wont come for at least another yearJohn Carlos Garza and Anne Beulke are already investigating how to replenish spring-run chinook in the upper reaches of the Klamath River Basin. Garza is a geneticist with the US National Oceanic and Atmospheric Administrations Southwest Fisheries Science Center and a researcher at the University of California, Santa Cruz, where Beulke is pursuing doctoral studies. Their research was motivated by a mystery of salmon behavior.

People have long recognized spring- and fall-run patterns, but scientists couldnt actually explain what caused this distinction. We found these curious patterns again and again, Garza says, even though they were the same type of salmon. Once they acquired the technology to quickly sequence fish DNA, however, the scientists started analyzing the genes of salmon that spawned at different times. We found a single region in the genome thats responsible for the difference between early- and late-migrating fish, Garza says. This led them to wonder whether they could re-create the missing spring-run salmon by crossing fall-run salmon with those that have the early-migration gene.

Garza and Beulke are now preparing to apply their discovery. They plan to crossbreed and release hatchery-raised spring-run chinook from the nearby Trinity River with fall-run chinook from the Klamath. When the fish return to the hatchery once more to spawn, theyll crossbreed them again with more fish from the Klamath. With every generation, youll get fish with a higher percentage of their ancestry from the Klamath River, he says.

Ideally, Garza and Beulke should begin their project this September to take advantage of the 2020 spawning season. Their work was scheduled to start in March, but stakeholder agencies have been slow to agree. The current pandemic may influence their schedule, too. I cant even get into the lab right now, Beulke says.

Although other plans have proposed reintroducing spring-run fish from nearby rivers, Garzas method has the advantage of preserving the evolutionary history of the Klamath River fish. During his analyses, Garza noticed that some fall-run salmon included genetic descendants of the Klamaths earlier spring-run fish. Crossing spring- and fall-run fish from within the river, then, would enable new spring-run generations to also preserve the adaptive genetic patterns of their Klamath ancestors.

At this point, I like Carloss approach, says Kathleen OMalley, a geneticist at Oregon State University. Its a great opportunity to test the connections between a genomic region and run timing. There are a lot of variables, she adds, but its certainly a worthwhile project. It may take more years than anticipated, though, to actually get enough data points.

Garza is comfortable taking the long view. This is a process that occurs naturally, he says. Were just accelerating things. Within 10 years, we could have thriving spring-run chinook salmon populations.

After all, the dams have been up for 100 years.

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Coming Home to the Klamath - Hakai Magazine

CHICAGO--(BUSINESS WIRE)--Please replace the release with the following corrected version due to multiple revisions.

The updated release reads:

BASE10 AND DNA LINK COVID-19 ANTIBODY TEST YIELDS PROMISING RESULTS

DNA Links Serology Test Showed High Degree of Sensitivity and Specificity for Detecting COVID-19 IgG Antibodies

BASE10 Genetics, Inc. (BASE10) announced the results of an independent study that showed 95% sensitivity and 100% specificity for SARS-Co-V-2 IgG antibodies using AccuFind COVID19 IgG test by DNA Link, Inc. The study was performed at John Hopkins University.

BASE10 offers a COVID-19 Tracking and Recovery Program that assists employers in launching testing and monitoring strategies for COVID-19. The company has been working to incorporate antibody testing to track the full life cycle of SAR-Co-V-2.

Having a reliable COVID-19 antibody test solution is important to our clients in understanding how the virus has affected their specific population. Our team and DNA Link have worked hard these past months to reach this important milestone, says Dr. Michael Fang, BASE10 CEO.

The two companies now plan additional studies with a selected number of BASE10 clients to further meet regulatory compliance and improve clinical usability. We want to work very closely with regulatory bodies in everything we do, while making sure good tests are available to patients and their providers at the right place and time, says Elizabeth Freund, BASE10s VP of Innovation.

Solid science is a valuable commodity in these times of uncertainty, and we are committed to provide the scientific rigor of AccuFind COVID19 IgG to the world, says Dr. Jong-Eun Lee, CEO of DNA Link. We look forward to continuing to gain traction with BASE10 on this important mission.

_____________________

About BASE10 Genetics, Inc.

BASE10 is a precision medicine company based in Chicago. BASE10s proprietary platform identifies precision diagnostics technologies with high potential for improving health outcomes, and creates turnkey disease management solutions to be deployed at scale for insurance payors.

Media inquiries: media@base10genetics.com

About DNA Link, Inc.

Established in 2000, DNA Link is a genomics company based in Korea. The company produces high-quality genomic data through up-to-date technologies, discovers biomarkers for molecular diagnostics and precision medicine. DNA Link strives to lead personalized medicine and new drug target identification.

Media inquiries: ikjun.choi1@gmail.com +82-10-6291-6180

Continued here:
CORRECTING and REPLACING BASE10 and DNA Link COVID-19 Antibody Test Yields Promising Results - Business Wire

Sign up here for our daily coronavirus newsletter on what you need to know, and subscribe to our Covid-19 podcast for the latest news and analysis.

Novo Nordisk A/S, the Danish drugmaker, is exploring whether a new class of medicines that helps people lose weight and control diabetes also has potential in fighting Covid-19.

Research shows people afflicted by obesity and diabetes often fare worse in trying to overcome SARS-CoV-2. Now initial analysis of electronic medical records shows that GLP-1 drugs, which help patients keep blood sugar levels in check, could be a very meaningful therapy in helping people with diabetes battle Covid-19, Novo Chief Scientific Officer Mads Krogsgaard Thomsen said in an interview. He pointed to evidence the virus attacks cells that produce the hormone insulin.

The early indication is that the GLP-1 class is actually beneficial in Covid-19, he said. Thats not unexpected because this is the class of agents that target the risk factors for bad Covid-19 outcomes.

Novo shares recouped earlier losses to trade down 0.2% at 11:40 a.m. in Copenhagen.

GLP-1 drugs include Novos Ozempic for diabetes and Saxenda for obesity. Sales of such drugs, which also include Eli Lilly & Co.s Trulicity and AstraZeneca Plcs Bydureon, totaled more than $11 billion last year, according to a report from Grand View Research.

Novo, the worlds biggest maker of diabetes drugs, is studying the role such medicines could play as researchers and governments rush to find treatments to combat the coronavirus. The U.S. last month cleared use of convalescent plasma -- which uses blood from people who have recovered from Covid-19 to help those currently infected -- on an emergency basis for some cases.

That added to a growing list of therapies available to doctors. In May, regulators granted emergency authorization to the Gilead Sciences Inc. antiviral drug remdesivir, while dexamethasone, a widely available generic anti-inflammatory drug, has shown life-saving promise.

Patients with Covid-19 can suffer from an inflammatory condition in which the immune system overreacts to the virus, causing damage that is worse than the infection itself. Studies show that semaglutide, the key ingredient in Ozempic, dampens systemic inflammation in people with diabetes and obesity, Thomsen said.

Novo is carrying out further studies and will make the results public if it can substantiate the preliminary data, he said. Thomsen added that theres no clinical evidence that GLP-1 drugs have an antiviral effect on Covid-19.

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Novo has bet on GLP-1 drugs including Ozempic, forecast by analysts to generate $3.4 billion in sales in 2020. Saxenda is expected to cross $1 billion in sales this year. The company expects regulators to decide whether to approve semaglutide in obesity at the end of next year, or the middle of 2021 if it decides to use a priority review voucher, Thomsen said.

Research indicates that obese and overweight people are at high risk of suffering severe cases of Covid-19, with a French study last month finding that only one in 10 who end up in intensive care with the disease were in a range of healthy weight. Another report in August highlights concerns future vaccines for Covid-19 could be less effective for individuals with obesity due to a weakened immune response.

Obesity, hypertension and diabetes are big risk factors for bad outcomes, according to Thomsen. But it is also so that the virus puts further stress on your cardiometabolic condition.

(Updates with shares in fourth paragraph, obesity drug timeline in ninth paragraph, research in tenth paragraph)

Before it's here, it's on the Bloomberg Terminal.

View original post here:
Drugs That Fight Diabetes and Obesity May Treat Covid-19 - Bloomberg

Just because you have type 2 diabetes doesnt mean you cant ever let anything sweet pass your lips again. With a bit of strategizing, there are ways you can satisfy your cravings from time to time.

According to the American Diabetes Association (ADA), if you have diabetes, you can absolutely include sweets and desserts in your diet, as long as theyre part of a healthy eating plan and you dont overindulge. The ADA also recommends working with a registered dietitian, a certified diabetes care and education specialist (CDCES), or another diabetes healthcare professional to help you formulate an eating plan thats right for you.

When you eat or drink carbohydrates, such as sugar, starch, and fiber, your body breaks them down into glucose, raising levels in your blood, according to the ADA. If you have type 2 diabetes, your body isnt able to use insulin efficiently to move this glucose from your blood into cells, where its used for energy. So its important to take steps to make sure your glucose levels dont spike too high.

You also want to make sure you eat healthy foods that are nutritious and high in vitamins, minerals, and fiber, and avoid or eat only small amounts of foods that contain unhealthy ingredients such as added sugar, high amounts of sodium, and unhealthy fats.

Many sweets, including cakes, cookies, and candy, tend to be highly processed and chock-full of added sugar, refined flour, and saturated fats, which is why they should be enjoyed in reduced portion sizes as an occasional treat.

Try these tips from diabetes nutrition experts to include sweet treats in your healthy eating plan.

1. Allow yourself the occasional treat. Deprivation isnt likely to work, says Karen Lau, a registered dietitian and CDCES at Joslin Diabetes Center in Boston. Completely eliminating treats from your diet may backfire, and you may end up craving those foods more, notes Lau.

2. Plan ahead. Consider how many carbs youre getting in your meal, not just in your dessert, says Tami Ross RD, CDCES, author of What Do I Eat Now? A Guide to Eating Well with Diabetes or Prediabetes and a spokesperson for the Association of Diabetes Care and Education Specialists (ADCES). That total number should factor into your calculation of what you will eat on days you have dessert or a sweet snack.

Make sure the meal is balanced with other foods. Cut out carbs from the main dish, and save it for dessert instead, says Lau. For example, if youre planning to have dessert, skip the bread, pasta, or side of mashed potatoes at dinner.

3. Be mindful of sugar-free foods. Kristen Smith, RDN, a spokesperson for the Academy of Nutrition and Dietetics, suggests choosing foods that dont list sugar in the ingredients and have sugar substitutes instead. But keep in mind that these foods are often still made with flour and other carbohydrate-containing ingredients, says Smith.

4. Pay attention to what you drink. You probably know that regular soda, juice, and fruit punch are loaded with sugar, but sports drinks, energy drinks, and bottled tea can also raise blood glucose. Plus, these sugary drinks can contain as many as several hundred calories in just one serving, according to the ADA.

Healthier options to help you stay hydrated while still giving your taste buds a treat include seltzer water with slices of lemon or lime or water infused with fruit, says Veronica Brady, PhD, an advanced practice registered nurse at MD Anderson Cancer Center and assistant professor of nursing at The University of Texas Health Science Center in Houston. She is also a spokesperson for ADCES.

5. Swap out ingredients. In the kitchen, use whole-grain flours, such as wheat or oat, or versions made from nuts, such as almond flour, to help with blood sugar control, advises Smith. You can also look for recipes that use fruit or fruit puree to reduce or eliminate sugar, says Smith.

6. Designate a sweet treat day. Depending on how well your diabetes is managed and what you and your diabetes management team decide is best for you, you can decide how many days you can budget in per week or month to indulge your sweet tooth.

7. Focus on fruit. Not only is fruit delicious enough to satisfy your sweet tooth, but it has the added bonus of being healthier, because it has fewer carbs and no added sugar, compared with processed sweets, explains Smith. Plus, fruit has fiber, which is helpful, because it takes longer to digest and is less likely to cause a rapid rise in blood sugar, she adds.

That said, its still important to watch portion size and sugar content when eating fruit. If youre making a smoothie, for instance, youll want to stick to about 4 to 6 ounces rather than drinking a giant tumbler of it, notes Dr. Brady. And if youre snacking on dried fruit or using it in a recipe, make sure you take into account how much sugar it contains: Just 2 tablespoons of raisins or dried cherries can contain as many as 15 grams of carbohydrates.

Some great ways to enjoy fruit:

8. Pick something you really like. Rather than settling for something that you might not like as much just because its labeled low sugar, eat smaller portions of something you love, notes Lau. Not only will eating what you prefer leave you feeling more satisfied, but opting for the diabetes-friendly version may also prompt you to eat more than you should.

9. Take a few bites and make them last. Split that piece of cake with a friend, or just have half of a large cookie. The first few bites are often what you enjoy most, notes Ross. Try to stick to two or three bites, and practice mindfulness about what youre eating.

The next time you take a bite of a treat, try this: Eat more slowly, think about what youre eating, and savor the taste, suggests Brady.

10. Freeze bite-size treats. One great way to have portion-controlled sweets on hand is to freeze bite-size Halloween candies, says Brady. Eat one of these slowly for a treat, she says.

11. Keep temptation out of sight. Ask family members to be supportive and help you stay healthy by not eating sweets in front of you or bringing cookies or candy into the house. Store ice cream at the back of the freezer, and dont put sweets in front or at eye level in the pantry, where you can see them, suggests Smith.

12. Identify your cravings. Are there circumstances where youre more likely to be tempted? Think about what makes you crave sweets, says Smith. Are you often influenced by a TV show or commercial? Be mindful of activities that might spark a craving, advises Smith. If you know youre always tempted when you pass a certain restaurant or billboard, for instance, try to avoid going that way.

13. Dont be too hard on yourself. You dont need to always aim for 100 percent, notes Lau. Instead, she recommends striving to strictly follow your diabetes diet at least 80 percent of the time and allowing yourself the occasional indulgence.

Excerpt from:
How to Satisfy a Sweet Tooth if You Have Type 2 Diabetes - Everyday Health

The "United Kingdom Diabetes Market, By Continuous Glucose Monitoring (CGM), Blood Glucose (SMBG) Device, Insulin Pen, Insulin Pump, Reimbursement Company Analysis & Forecast" report has been added to ResearchAndMarkets.com's offering.

The report provides a complete analysis of the United Kingdom Insulin Devices Market.

United Kingdom Diabetes Market expected to reach USD 4.33 Billion by the year 2025

The market of Insulin Pen, Insulin Pump, Continuous Glucose Monitoring (CGM) Device and Self Monitoring Blood Glucose Device are growing due to the rising awareness for diabetes in the United Kingdom.

In the United Kingdom, there are more than a million people diagnosed with diabetes, and the number continues to grow. Diabetes is one of the biggest health challenges the United Kingdom is facing today. The growing health crisis and its complications will increase awareness of the risks, improve self-management among people with diabetes, bring about wholesale changes in lifestyle and improve access to integrated diabetes care services.

The National Service Framework (NSF) program is improving services by setting national standards to drive up service quality and tackle variations in care. In 2019, The Association of British HealthTech Industries (ABHI) had launched a diabetes section, enabling diabetes technology companies to work together in the first forum of its kind. The ABHI group is for any health technology company with an interest in diabetes care, from CGM and insulin pumps to apps.

Key Topics Covered

1. Introduction

2. Research & Methodology

3. Executive Summary

4. Market Dynamics

4.1 Growth Drivers

4.1.1 Rising Diabetes Mellitus in an Aging Population

4.1.2 Rising prevalence of diabetes in various age groups

4.1.3 Benefits of Insulin Pump over Multiple Daily Injection

4.1.4 Lifestyle-Compatible Treatment Options and Technological Advancement in Insulin Pump Devices

4.2 Challenges

4.2.1 Technological advancements in insulin infusion devices

4.2.2 Blood Glucose Meter Accuracy Problem

4.2.3 Low Compliance of Glucose Monitoring & Inadequate Reimbursement for SMBG Supplies

4.2.4 Safety Issues in Insulin Pump Devices

4.2.5 Difficulties Associated with the Pump

4.2.6 Adherence

5. United Kingdom Diabetes Market

6. United Kingdom Diabetes Population

6.1 United Kingdom Diabetes Population & Forecast

6.2 Type 1 & Type 2 Diabetes Population and Forecast

7. Market Share Analysis - United Kingdom Diabetic

7.1 By Types

8. Continuous Glucose Monitoring Market (CGM) - United Kingdom Market & Users

8.1 CGM Market by Components

8.1.1 Glucose Sensor Market & Forecast

8.1.2 CGM Transmitter Market & Forecast

8.2 United Kingdom - CGM User (2011-2025)

8.3 CGM Reimbursement in United Kingdom

9. Blood Glucose Device (SMBG) - United Kingdom Market & Users

9.1 Market

9.1.1 Type 1 & Type 2 (Diabetes)

9.2 Test Strips Market and Forecast

9.2.1 Type 1 & Type 2 (Diabetes)

9.3 Lancet Market and Forecast

9.3.1 Type 1 & Type 2 (Diabetes)

9.4 Meter Market and Forecast

9.4.1 Type 1 & Type 2 (Diabetes)

9.5 Blood Glucose Device (SMBG) Users and Forecast

9.5.1 Type 1 & Type 2 (Diabetes)

9.6 Reimbursement of Blood Glucose Devices in United Kingdom

10. Insulin Pen - Market & User

10.1 Insulin Pen User

10.1.1 Disposable Insulin Pen Users

10.1.2 Reusable Insulin Pen Users

10.1.3 Smart Insulin Pen Users

10.2 Insulin Pen Market

10.2.1 Disposable Insulin Pen Market

10.2.2 Reusable Insulin Pen Market

10.2.3 Smart Insulin Pen Market

10.3 Insulin Pen Needle Market

10.4 Reimbursement Policies

11. Insulin Pump - Market & Users

11.1 Insulin Pump Market & Forecast

11.1.1 Type 1 & Type 2 (Insulin Pump Market & Forecast)

11.2 Insulin Pump Users

11.2.1 Type 1 & Type 2 (Insulin Pump User & Forecast)

11.3 Differentiation Points of Insulin Pump Products in the United States

11.3.1 Animas Vibe

11.3.2 Medtronic 530G with Enlite

11.3.3 Insulet OmniPod

11.3.4 Tandem t: slim

11.3.5 Roche Accu-Chek Combo

11.4 Training Model for Patients & HCP - of Medtronic, Animas, Insulet Corp. & Tandem Diabetes Care

11.4.1 Medtronic

11.5 Insulet Corporation

11.5.1 Training Structure for New Patients - Insulet Corporation

11.6 Animas Corporation

11.6.1 Training Modules for New Patients

11.6.2 Training Modules for HCP (Health Care Professional)

Story continues

11.7 Tandem Diabetes Care

11.8 Reimbursement Policies on Insulin Pump

12. Insulin Pen - Company Analysis

12.1 B. Braun Melsungen AG

12.1.1 Overview

12.1.2 Initiatives & Recent Developments

12.1.3 Revenue

12.2 Eli Lilly

12.3 Artsana S.p.A.

12.4 BD

12.5 Novo Nordisk A/S

12.6 Owen Mumford Ltd.

12.7 Ypsomed AG

13. Insulin Pump - Company Analysis

13.1 Medtronic

13.1.1 Overview

13.1.2 Insulin Pump - Product Details

13.1.3 Insulin Pump - Latest Development & Trends

13.1.4 Revenue

13.2 Insulet Corporation

14. SMBG - Company Analysis

14.1 LifeScan Inc.

14.1.1 Overview

Read more:
United Kingdom Diabetes Market 2020-2025 Featuring Analysis of Companies Involved in Insulin Pens, Insulin Pumps, SMBG and CGM -...

For decades, two costly medical conditions have been rising on similar trajectories in America: obesity and type 2 diabetes (T2D). Over the last 40 years, adult obesity rates have more than doubled, with a similar rise in individuals with T2D. The link between these two conditions is further suggested by the fact that 70 percent of Americans are now living with obesity or overweight, and 90 percent of all T2D patients have obesity or overweight.

We also know there are strong medical connections between obesity and T2D. As an individuals BMI (body mass index) rises, their risk of developing prediabetes and type 2 diabetes also increases. This is especially true with increases in visceral, or abdominal, fat which is less responsive to insulin. The first line of treatment for T2D generally focuses on glycemic control, often with medications that promote weight gain.

Examining the connection between weight and T2D gives reason to look at more than glycemic control.

Going Beyond Simply Controlling Glucose Levels

Addressing obesity for patients with diabetes, however, enables the clinician to do more than simply control glucose levels: they can treat the underlying insulin resistance that drives T2D. Choosing medications that promote weight loss like GLP-1 agonists and SGLT-2 inhibitors over medications that promote weight gain like insulin and sulfonylureas can improve weight status providing added benefit to diabetes treatment. Unfortunately,two-thirds of people with obesity remain undiagnosed. Medical professionals cite lack of time as a major reason for why they dont discuss weight treatments with their patients, although patients who do receive obesity counselling from physicians trained in obesity medicine report receiving a higher quality of care.

More informed and effective obesity care translates to better diabetes prevention and care. Clinicians evaluating treatment for T2D should also consider obesity treatments ranging from lifestyle interventions to anti-obesity medications to bariatric surgery. For example, the risk of diabetes is reduced by 58 percent with a five to ten percent reduction of weight through lifestyle changes.

A Range of Cost-Effective Interventions

Bariatric surgery, typically associated with obesity treatment, can offer significant benefits for patients with T2D. Noted as a cost-effective intervention by the International Diabetes Foundation, bariatric surgery results in remission for most patients with T2D. Recently,a study published in the New England Journal of Medicine, compared an intensive lifestyle intervention to bariatric surgery and found similar improvements in weight loss and metabolic profile in patients with T2D.

All clinicians can guide patients towards better health outcomes when they understand the connection between obesity and diabetes. The Obesity Medicine Association(OMA) offers a wealth of resources that can help advance that understanding, including specialized continuing education tracks focused on managing adiposity-related diseases and the role of weight management in the treatment of diabetes.OMAs virtual fall conference, OvercomingObesity 2020, will highlight the latest research and best practices related to obesity. Additional OMA resources include The Obesity Algorithm, Obesity Treatment Proficiency Badges and American Board of Obesity Medicine (ABOM) preparation materials.

Health care professionals who embrace an approach to T2D treatment through medical, surgical and especially combined obesity interventions have the potential to make meaningful improvements for patients on multiple fronts.

For more obesity medicine resources or to become an OMA member, visit:www.obesitymedicine.org.

Nicholas Pennings, DO is board certified in Family Medicine and Obesity Medicine and is a fellow of the Obesity Medicine Association (OMA). He is an associate professor and chair of family medicine at Campbell University School of Osteopathic Medicine (CUSOM) and also serves as the director of the Campbell University Health Center. As a champion for advancing the education of current and future health professionals, particularly as it relates to obesity, Dr. Pennings is an executive director of clinical education for the Obesity Medicine Association. He has also infused obesity education into the medical school curriculum at CUSOM and has developed an online obesity education rotation through the OMA for clinicians in training.

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Improve diabetes prevention and care through obesity treatment - Medical Economics

Diabetes mellitus is an increasingly common disease in the United States and is one of the leading causes of death. It is more than just elevated glucose levels. Type 2 diabetes mellitus, as part of the metabolic syndrome, is often accompanied by obesity, hyperlipidemia and hypertension. It is a complex metabolic disease and is considered a heart disease equivalent.

Diabetes has such a huge impact on cardiovascular health that over a decade ago, the FDA started requiring cardiovascular outcomes data for any new antihyperglycemic drugs. While we have known for many years that improved glycemic control decreased cardiovascular risk, we did not have specific data that any particular drug decreased the incidence of cardiac morbidity or mortality. Now, several newer diabetes drugs have been shown to decrease the risk of either hospitalization due to cardiac events or cardiac death. This has changed the way pharmaceutical companies have been marketing their drugs and it has changed the way people look at diabetes.

People other than endocrinologists, that is. Endocrinologists have always treated diabetes as a cardiometabolic disease. As a matter of fact, the American Diabetes Associations (ADA) Standards of Medical Care in Diabetes includes a whole section on managing cardiac risk. For years, endocrinologists have been treating hyperlipidemia and hypertension as part and parcel of their diabetes management.

Ask an endocrinologist how many times they have started a patient on a statin after that patient had been told by other physicians that his cholesterol is normal. Or worse, how often another physician stops the patients statin because his level is good. Too many. Ive even had patients refuse statin therapy because their cardiologist told them they dont need it.

Patients with diabetes comprise a large portion of the population that endocrinologists see. There is now a push to create a new specialty, a new fellowship in cardiometabolic medicine. Most endocrinologists Ive communicated with are asking why? Why do we need this new separate fellowship? Isnt this what weve been doing all along?

If the argument is that there arent enough endocrinologists to go around (see my earlier post), then the answer isnt training more people in a different specialty, the answer is creating more endocrinologists. The answer is making endocrinology more attractive to medical students and residents.

Why go into endocrinology when our healthcare system rewards people for procedures and not cognitive work? It is my hope that the new CMS physician fee schedule and the new visit codes will correct some of this. In addition, we need more funding for endocrinology fellowship programs.

Only about 300 new endocrinologists complete training each year, meanwhile 1.5 million new cases of diabetes are diagnosed in the same time frame. Wouldnt it save the healthcare system millions of dollars to better compensate endocrinologists for managing diabetes and its comorbidities in order to decrease the need for cardiac testing and procedures and to prevent hospitalizations for cardiac events?

Diabetes is definitely a cardiometabolic disease. But we dont need a whole other specialty to start managing it. Endocrinologists have been at the front line of this all along.

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Cardiometabolic Health Fellowships: The Answer or Part of the Problem? - Endocrinology Network

Western eating habits have made their way to other countries, and an increase in diabetes is the unfortunate result.

September 5, 2020 by Diabetes Knowledge Leave a Comment

Worldwide rates of diabetes among the 65-plus population are on the rise, and have increased dramatically in the past 40 years. The US, China, and India have the highest rates of diabetes around the world. Diabetes puts seniors at a much higher risk for chronic wounds including life-threatening diabetic foot ulcers.

Diabetic foot ulcers can progress from an irritation on the bottom of the foot to a gangrenous limb. This would require amputation. Amputation, especially in developing countries is a result of diabetic foot ulcers. Wound experts can monitor the feet of diabetic patients for signs of a foot ulcer. Generally starting out as a red sore on the bottom of the foot. But seniors in developing countries dont always have easy access to wound care experts, making diabetes an even bigger threat to their overall quality of life.

A rise in diabetes is costly for any nations healthcare system. Threatening to reverse progress in countries like India and China. In both countries, many seniors rely on family members for care, and dont have access to expert wound care. Experts also estimate that both countries have high rates of undiagnosed cases, meaning that patients could be at risk for diabetic foot ulcers and not know it.

Patients in India are put further at risk for diabetic foot ulcers because of faulty footwear. However, one study found to be the cause of ulcers in one-fifth of patients.

The causes of diabetes in the U.S. are well known fast food and diets high in sugar provide an obvious explanation. But Western eating habits have made their way to other countries, and an increase in diabetes is the unfortunate result. Even in Japan, with a global reputation for a healthy diet, has also seen a dramatic spike in diabetes in the past few decades. This is due in part to the aging population the likelihood of developing diabetes increases with age. Along with the westernization of the Japanese diet.

In the Marshall Islands, a small group of islands near the Philippines, scientists have had a chance to study a dramatic dietary shift in a small population. Today, many locals subsist almost entirely on pre-packaged, imported food. As a result, over a quarter of the adult population suffers from diabetes.

It wasnt always this way. In the past, the Marshallese diet consisted mostly of seafood and local produce, and unsurprisingly, diabetes was practically non-existent. Researchers believe the introduction of white rice into the local diet may have started the trend toward more carbohydrate-rich, processed foods.

What can we learn from countries with especially low rates of diabetes? Italy has one of the lowest rates of diabetes in Europe, which tracks with recent studies. Research suggests that the Mediterranean diet is the best for lowering the risk of diabetes and obesity. A diet rich in healthy fats, in foods like fish and olives, as well as plenty of fresh produce. Seniors in long-term care may not have easy access to Mediterranean cuisine, but keeping those rough guidelines in mind can help seniors in long-term care make healthier choices and keep their diabetes symptoms in check.

Previously published on diabetesknow

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Diabetes Around the World on the Rise? - The Good Men Project

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Bengaluru: An analysis of over 1,30,000 adults from 21 countries over nearly a decade has indicated a high risk of diabetes linked with the consumption of white rice. The risk is most prominent for the South Asian population, according to findings from a new, large-scale, long-term study.

The study was an international collaboration between researchers from various countries including India, China, and Brazil in Asia, North and South America, Africa and Europe.

Led by Bhavadharini Balaji of the Population Health Research Institute, Hamilton Health Sciences and McMaster University, Canada, the study was a part of the institutes Prospective Urban Rural Epidemiology (PURE) project.

The findings were published in the Diabetes Care journal in its September issue.

White rice is milled rice that has its germ (the part that sprouts), bran (hard outer layer), and husk (outer covering) removed. The polishing of rice further results in a bright and shiny appearance. While white rice has an appealing appearance and can be stored longer, the milling and polishing process remove nutrients such as vitamin B.

White rice has been linked to an outbreak of beriberi in Asia, caused by vitamin B-1 deficiency. It also causes the blood sugar levels to spike upon consumption due to its high glycemic index.

Globally, 42.5 crore people currently have diabetes, and this number is expected to increase to 62.9 crore by 2045, according to the International Diabetes Federation.

Studies have alluded to risk of diabetes associated with white rice for a few decades now, although findings have been contradictory. A 2012 study found that each extra serving of white rice increased the risk for diabetes by 11 per cent.

However, findings change depending on which country studies were conducted in. For example, a study of over 45,000 participants in Singapore found no substantial increase in diabetes was associated with white rice consumption.

Most such studies were limited to single countries. To beat this barrier, the authors of the new study extended it to 21 nations Argentina, Bangladesh, Brazil, Canada, Chile, China, Colombia, India, Iran, Malaysia, occupied Palestine territory, Pakistan, Philippines, Poland, South Africa, Saudi Arabia, Sweden, Tanzania, Turkey, United Arab Emirates, and Zimbabwe.

However, the South Asian population seems to show a pattern with white rice consumption and diabetes, despite a number of other lifestyle factors that increase the disease risk.

South Asians are genetically more predisposed to get diabetes, so there are both lifestyle as well as biological reasons for the high diabetes incidence, said Bengaluru-based physician Dr Gowri Kulkarni.

To understand the link between white rice and diabetes in South Asia, the researchers compared the data from India, Bangladesh, and Pakistan with the rest of the world.

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The study involved 132,373 individuals between the ages of 35 and 70, from these 21 countries, who were monitored for nine and a half years. Of these, 6,129 developed diabetes over the course of the study.

Participants were considered if they consumed more than one cup or 150g of cooked rice a day. Overall, the average white rice consumption was 128g a day among the study participants.

However, the team found that the highest consumption of white rice was seen in South Asia at 630g a day, followed by South East Asia at 239g and China at 200g per day. High consumption of rice resulted in lower consumption of other foods like wheat, fibre, red meat, and dairy products.

Carbohydrates make up nearly 80 per cent of calories consumed in many South Asian countries. Since the 1970s, carbs have become increasingly polished and refined as well, losing a lot of nutrition in the process.

Rapid urbanisation and economic development, especially in low- and middle-income countries, have led to a dramatic change in dietary intake and increased physical inactivity, which are related to the obesity epidemic.

Talking about the findings, Mumbai-based nutritionist Priya Kathpal said, I wouldnt say every white rice-eating family would have a diabetic person in their family A lot depends on the quantity of rice eaten, what its eaten with, and how frequently.

Also read:Brainwaves study can tell if a worker can handle crisis situation, IIT Madras research says

China and India are two of the worlds largest countries where rice is the staple food. Both also lead in the incidence of diabetes. However, the researchers found that there wasnt a significant association with white rice consumption and diabetes in China.

There could be many reasons for this, apart from other lifestyle factors. The scientists believe that the kind of rice the Chinese eat (sticky rice) could make a difference.

In India, studies have shown that during the last four to five decades of replacing hand-pounded rice with industrially milled white rice, the prevalence of diabetes in urban areas in India increased from 2 per cent in the 1970s to 25 per cent in 2015, and in rural areas from 1 per cent to 1416 per cent, respectively. White rice is considered to be one of the many main drivers of the trend, which followed improved socioeconomic growth and lifestyle modifications.

Studies have shown that substituting white rice with unpolished brown rice decreases the glycemic response by 23 per cent and the fasting insulin response by 57 per cent in overweight Asian Indians, but consumers do not tend to prefer brown rice due to its inconvenience of longer cooking duration, greater chewing difficulty, and lack of visual appeal.

Several patients that Ive asked to switch to brown rice have faced difficulty, as everyones grown up eating white rice, said Kathpal.

Taste is a huge factor, and brown rice often doesnt taste the same as white with vegetable curries and dals. Sometimes, white rice alternatives like even millets can be more expensive or not as easily available too, she said.

Doctors and dieticians are hesitant to recommend diets that are more expensive and less easily available even if they are healthier, as patients tend not to adopt them successfully.

A daily diet should always be easy to maintain and easily available. Only then can it be sustainable, said Kulkarni. Indians in general have poor protein intake in diet, and this has to do with available resources and choices. Most calories are from carbohydrates as they are cheap.

According to the researchers, in countries where rice is consumed the most or as a staple, the risk of increased diabetes among the public can be lowered by substituting white rice with alternate forms of healthier rice versions and adding more legumes or pulses to food.

Also read:One drink? Or two? Forget the guidelines, less is always better

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White rice linked to diabetes, especially in South Asia, says 21-nation study done over 10 yrs - ThePrint

Cypress resident Anne Imber takes a photo with her son Tristan Edgar, who was diagnosed with Type 1 diabetes in 2009 at the age of 12.

Cypress resident Anne Imber takes a photo with her son Tristan Edgar, who was diagnosed with Type 1 diabetes in 2009 at the age of 12.

Photo: Courtesy Of Anne Imber / Provided By Kimberly Pace, 9th Wonder

Cypress resident Anne Imber takes a photo with her son Tristan Edgar, who was diagnosed with Type 1 diabetes in 2009 at the age of 12.

Cypress resident Anne Imber takes a photo with her son Tristan Edgar, who was diagnosed with Type 1 diabetes in 2009 at the age of 12.

Cypress mother advocates with Beyond Type 1 DKA Campaign to differentiate diabetes symptoms from viruses like COVID-19

Excessive thirst, frequent urination, unexplained weight loss and exhaustion. If Cypress mother Anne Imber and her son had known what these symptoms might indicate, he could have been treated sooner for the serious health complications from his undiagnosed Type 1 diabetes.

Type 1 diabetes is a chronic autoimmune condition that causes the bodys immune system to mistakenly attack the insulin-making beta cells of the pancreas, explained Dr. Daniel DeSalvo, pediatric endocrinologist at Baylor College of Medicine and Texas Childrens Hospital.

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If a person with diabetes isnt receiving insulin, then they can develop a life-threatening condition called diabetic ketoacidosis, or DKA. It causes stomach pain, nausea, vomiting, tiredness, lethargy, sometimes it can cause rapid or heavy breathing, and if its severe it can lead to the point of confusion or even unconsciousness, DeSalvo said.

DeSalvo is on the science advisory board for Beyond Type 1, a nonprofit focused on building awareness and support for people with Type 1 and Type 2 diabetes worldwide.

Among the organizations initiatives is to prevent the development of DKA by educating people about the warning signs of Type 1 diabetes.

Imber became a Beyond Type 1 volunteer after her sons diabetes diagnosis and has been advocating on behalf of the DKA Campaign.

Texas was actually one of the first states to adopt the Beyond Type 1 DKA Campaign, Imber said. We have a really passionate group of diabetes advocates in the Houston area, and especially in the Cypress area, because we have a Type 1 diabetes school advocacy group.

One factor that can lead to the delayed diagnosis of Type 1 diabetes is the symptom similarities to some viral illnesses such as the flu or a stomach virus, DeSalvo said. During the COVID-19 pandemic, making people aware of Type 1 diabetes telltale symptoms is of vital importance.

On HoustonChronicle.com: Ventilation expert reveals how Texas schools can stop the spread of COVID in classrooms

Its an issue that Imber knows all too well.

Imber said her son Tristan was 12 years old when he and his sister contracted the swine flu in 2009 during the H1N1 pandemic.

My daughter immediately bounced back, Imber said. She was on the mend in two days. My son, he went down with the swine flu and then he never recovered his full energy that hed had before. He started suffering from extreme exhaustion. He started having a lot of weight loss.

There were many factors that Imber thought might be at play he was slimming due to a growth spurt; he had started running cross-country; and, of course, hed just been sick with the swine flu.

He would come home incredibly exhausted, falling asleep, and I really attributed it to the swine flu his recovery from the swine flu just not taking the path that his sister had taken, Imber said.

He continued to go downhill over the next month, losing 20 pounds in just four weeks. Hed tell his mom he was starving but was too nauseous to eat. He became more emotional than usual, Imber said. She knew something was wrong, so she made a Friday appointment with a pediatrician.

They knew immediately how bad it was, but they wanted us to come back Monday morning for a fasting blood glucose (test), she said.

Halloween happened to fall on that weekend. Thank god he did not eat his candy, Imber said. He was waiting for his braces to come off on Tuesday.

By Tuesday morning, his pediatrician had called to relay his diagnosis Type 1 Diabetes.

They realized Tristan had been going into phases of DKA because of his untreated condition.

Because he was running cross-country, his blood sugar would go really high and then it would drop again because of the activity, Imber said. So, it was a really unusual case and thats one of the reasons it took so long to manifest in really obvious terms of, something was seriously wrong.

Imber believes something as simple as an informational poster in the doctors office waiting room, like the ones distributed by the DKA campaign, could have tipped them off sooner.

He hadnt been sharing the excessive thirst and the frequent urination because 12-year-old boys dont do that with their moms; they dont talk about those things, she said. And I know had he been sitting in that office at that time with the DKA Campaign poster there, he would have been able to say, Mom, Ive been having these symptoms and that wouldve really prompted us to get immediate help Friday versus waiting until Tuesday to seek out support for him.

Nowadays, Imber said a DKA diagnosis warrants immediate hospitalization; but at the time, doctors felt the severity level of Tristans condition was low enough to treat him outside of a hospital. Imber said her son was fortunate to not have experienced the organ failure that some do from DKA. She knows of several cases in which lives have been lost because of an incorrect or delayed diagnosis. If her son had not been diagnosed in a timely manner, Imber doesnt doubt he wouldve ended up in the hospital.

We were lucky that he did not incur that seriousness of it, but we immediately saw relief from being able to be treated with the insulin under the care of an endocrinologist, and then started that learning process on how to manage it with the insulin dosing since his pancreas was no longer able to provide that hormone to regulate his food intake, Imber said.

Imber had attributed several of Tristans diabetes symptoms to the residual effects of his flu recovery a relatively common misidentification among people with undiagnosed diabetes, she said.

When its flu season, youll see a lot of people struggling and thinking, It is just the flu, but in reality there are some symptoms that really stand out that frequent urination, that excessive thirst that really differentiate from a flu symptom, Imber said.

The COVID-19 pandemic presents similar challenges for the diagnosis of Type 1 diabetes and DKA, explained Beyond Type 1 Leadership Council Member Michelle Berman.

We are seeing many families protecting themselves and wanting to avoid visits to doctors or the hospital, Berman said. And on top of that, if they arent armed with the knowledge of the warning signs, they also arent taking action when they appear. We really want families to get to the hospital or contact their physician right away, in spite of COVID or in addition to looking for the COVID warning signs. Type 1 diabetes does not stop just because theres a pandemic.

Berman serves as the National Family Advocate for the DKA Campaign.

Her child was diagnosed with Type 1 diabetes in 2007. She took him to the doctor after hed fainted from what she thought was abnormal blood pressure. After his diagnosis, Berman felt frustrated that shed never been made aware of the warning signs for Type 1 diabetes.

Berman learned of the Beyond Type 1 organization in 2016.

So, I partnered with Beyond Type 1 as a family advocate and began working on partnerships with the American Academy of Pediatrics and individual chapters in each state, Berman said. Together, Beyond Type 1 and the AAP partnered and brought awareness to families. Currently, I think theres 25 states across the country that partnered with Beyond Type 1 and disseminated materials warning signs, posters, fliers and handouts to families at well visits.

The campaign began its push to disseminate the information in November of 2016 and has distributed the material in 25 states to more than 28,000 pediatric offices serving over 90 million patients a year, according to Berman.

And thats just phase one.

With a grant from the Helmsley Charitable Trust Foundation, we were able to expand the campaign into phase two, into 10 states across the country, Berman said.

Phase two targets the general public, schools and businesses such as gyms.

In February of this year, the National Association of School Nurses partnered with Beyond Type 1 with the awareness campaign, and so thats been very exciting to expand beyond the pediatricians, Berman said. With the school nurses, were raising awareness of the warning signs, really to be distributed to tens of thousands of school nurses nationally in the United States. So, weve been really thrilled with the awareness and partnerships with this campaign.

For more information or to get involved, visit http://www.beyondtype1.org/dkacampaign or email dka@beyondtype1.org. Find Beyond Type 1 on social media: @beyondtype1.

mfeuk@hcnonline.com

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Cypress mother advocates with Beyond Type 1 DKA Campaign to differentiate diabetes symptoms from viruses like COVID-19 - Chron

LEONARDTOWN, MD (September 3, 2020) The St. Marys County Health Department is pleased to announce that the Overdose Response Program, Tobacco Cessation Program and Diabetes Prevention Program will be offered virtually for community members this Fall.

Overdose Response Program

The Overdose Response Program provides free training, open to anyone who would like to learn how opioids affect the body, how to recognize the signs of opioid overdose, and how to care for someone who may be experiencing an overdose until emergency help arrives. Participants can receive an overdose response kit via scheduled curb-side pickup that includes naloxone (Narcan) a life-saving medication that may be able to restore the breathing of someone who has overdosed on opioids.

Next Session: Wednesday, September 30, 2020, from 6:00 7:00 p.m.Learn moreor register at:www.smchd.org/overdose

Tobacco Cessation Program

The Tobacco Cessation Program is free and that takes place over the course of 8 weeks (weekly 1 hour sessions). Participants learn behavioral modifications, stress management, and other techniques to help them quit using tobacco products.

Next Series: Tuesdays, September 15, 2020November 10, 2020 from 5:306:30 p.m. Learn moreor register at:www.smchd.org/tobacco

Diabetes Prevention Program New!

The Diabetes Prevention Program helps participants establish and stick with positive lifestyle changes, such as healthy eating habits, physical activity and positive stress management, which can prevent or delay the onset of Type 2 diabetes. This free program includes 16 weekly sessions, followed by monthly sessions for ongoing support from a lifestyle coach.

Next Series: September 25, 2020 September 24, 2021 from 2:00 3:00 p.m.Learn more or register at:www.smchd.org/dpp

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Virtual Programs Announced for Overdose Response, Tobacco Cessation and Diabetes Prevention - The Southern Maryland Chronicle

Thousands of diabetes patients in the U.K. have been given hope that their illness could be put into remission by a soup-and-shake diet plan being offered by the National Health Service (NHS).

Those with Type 2 diabetes, which is more likely to affect people who are obese or overweight, are being encouraged to take up the low-calorie liquid diet after a trial involving 5,000 people showed that almost half of the participants saw their diabetes go into remission after a year.

Around 12.3 million people in the U.K are at risk of developing Type 2 diabetes, while in the U.S., one-third of Americans could be on their way to developing the disease, with 84 million Americans having pre-diabetes, a condition where people have higher than normal levels of blood sugar, according to the Center for Disease Control (CDC).

Around 10 percent of the U.S. population has diabetes, according to the CDC.

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Diabetes is also expected to cost the NHS 10 billion a year.

The year-long diet plan is being offered by the NHS to an initial 10 areas of England and only those who have been diagnosed with the condition in the last six years will be considered for the scheme.

Participants will be provided with diet replacement products such as shakes and soups for three months alongside support with exercise plans as well as managed plans to reintroduce ordinary, nutritious food.

Professor Jonathan Valabhji, NHS national clinical director for diabetes and obesity said: "This is the latest example of how the NHS, through our Long Term Plan, is rapidly adopting the latest evidence-based treatments to help people stay well, maintain a healthy weight and avoid major diseases.

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"There has never been a more important time to lose weight and put their Type 2 diabetes into remission, so it's good news for thousands of people across the country that practical, supportive measures like this are increasingly available on the NHS."

It comes as Public Health England data revealed that those with diabetes were more vulnerable to the COVID-19 virus, with a third of people who died in hospital with COVID-19 also having diabetes.

A new study published by the University of North Carolina showed that people with obesity are 113 percent more likely to be admitted to hospital with coronavirus and 74 percent more likely to need intensive care treatment.

Bev, who was one of the first patients to benefit from the diets during trials, said: "My goal for the first eight weeks of the low-calorie diet was to lose 5 percent of my body weight which I achieved in six weeks and in total I've lost over 10kgs, my Type 2 diabetes is now in remission and I no longer have to take any medication I am over the moon.

"Since the low-calorie diet program, my mindset has totally changed for the better and I look at food differently now my shopping habits are far healthier and, when I eat out, I'll go for a healthier option. The program has taught me moderation."

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Britain Begins Diabetes Trial After 50 Percent Recover Within One Year - Newsweek

For people who are struggling with diabetes, a late-breaking research has found out that it can be prevented or even be reversed by losing weight.

The research was presented on Monday at ESC Congress 2020.

In 2019, approximately 463 million people worldwide had diabetes, of which the vast majority (around 90 per cent) had Type 2 diabetes. It doubles the risk of coronary heart disease, stroke and death from cardiovascular complexities. Obesity is the main modifiable cause of Type 2 diabetes, while genetic make-up may also identify individuals with a greater likelihood of developing the condition.

"Because we are born with our genes, it might be possible to pinpoint early in life who has a high chance of developing diabetes during their lifetime," said principal investigator Professor Brian Ference of the University of Cambridge, UK, and the University of Milan, Italy.

"We conducted this study to find out if combining inherited risk with current body mass index (BMI) could identify people at the highest risk of developing diabetes. Prevention efforts could then concentrate on these individuals," Ference added.

The study included 445,765 participants of the UK Biobank. The average age was 57.2 years and 54 per cent were women. Inherited risk of diabetes was assessed using 6.9 million genes. Height and weight were measured at enrolment to calculate BMI in kg/m2. Participants were divided into five groups according to the GC of diabetes. They were also divided into five groups according to BMI.

Participants were followed-up until an average age of 65.2 years. During that period, 31,298 developed Type 2 diabetes.

Those in the highest BMI group (average 34.5 kg/m2) had an 11-fold increased risk of diabetes compared to participants in the lowest BMI group (average 21.7 kg/m2). The highest BMI group had a greater likelihood of developing diabetes than all other BMI groups, regardless of genetic risk.

"The findings indicate that BMI is a much more powerful risk factor for diabetes that genetic predisposition," said Professor Ference.

The investigators then used statistical methods to estimate whether the likelihood of diabetes in people with a high BMI would be even greater if they were overweight for a long period of time. They found that the duration of elevated BMI did not have an impact on the risk of diabetes.

Professor Ference said: "This suggests that when people cross a certain BMI threshold, their chances of diabetes go up and stay at that same high-risk level regardless of how long they are overweight."

He noted that the threshold is likely different for each person and would be the BMI at which they start to develop abnormal blood sugar levels.

"The findings indicate that most cases of diabetes could be avoided by keeping BMI below the cut-off which triggers abnormal blood sugar. This means that to prevent diabetes, both BMI and blood sugar should be assessed regularly. Efforts to lose weight are critical when a person starts to develop blood sugar problems," said Ference

"It may also be possible to reverse diabetes by losing weight in the early stages before permanent damage occurs," he added.

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Diabetes can be prevented, or even be reversed - here's how - DNA India