StemCell Therapy

Ridding the world of Covid-19 is a lucrative enterprise.

As analysts divvy up the multibillion-dollar rewards in line for the leaders in the race to roll out the first pandemic vaccines, no one is forgetting to track just how much the top company founders have on the line now as stock prices gyrate ever higher.

Bloomberg, which tracks these numbers with missionary zeal, puts Sahins net worth today at $5.1 billion following the most recent rise of BioNTechs $BNTX share price. The biotechs partner, Pfizer, is aggressively pushing ahead with plans to get the first approved vaccine in play, and Bernstein believes that will put the two collaborators in line for the largest market share for next year.

Unlock this story instantly and join 94,800+ biopharma pros reading Endpoints daily and it's free.

SUBSCRIBE SIGN IN

Continue reading here:
#ASH20: Orca's team showcases their first cut of the data on promising cell purification work for HSCT - Endpoints News

Results from a study using cutting-edge genome editing for hard-to-treat blood disorders were presented at the 62nd American Society of Hematology (ASH) Annual, Meeting and Exposition held virtually from December 5 8, 2020.

The researchers reported promising interim safety and efficacy data from 10 patients who received an investigational gene-editing based therapy, CTX001, the first to test a CRISPR-Cas9 gene-editing therapy in humans for a genetic disease.

Sickle cell disease affects approximately 100,000 people in the United States. And globally, approximately 400,000 infants are born each year with sickle cell disease. [3][4]

Recognized for its abnormally shaped red cells, sickle cell disease can cause a variety of health problems, including hemolytic anemia, episodes of severe pain, called vaso-occlusive crises, as well as progressive and irreversible organ damage, and strokes, leading to a decreased health-related quality of life (hrQoL), and early death.[5]

Standard of of careToday, the standard curative treatment for sickle cell disease is allogeneic hematopoietic stem-cell transplantation. If matched with a sibling donor, transplantation is known to be curative in more than 90% of patients. This approach is approach has limitations including a higher risk of complications in older patients, a risk of severe graft-versus-host disease (GVHD), and lack of an available matched sibling in approximately 80% of cases.[6][7]

Patients with transfusion-dependent thalassemia are dependent on blood transfusions from early childhood. The only available cure for both diseases is a bone marrow transplant from a closely related donor, an option that is not available for the vast majority of patients because of difficulty locating matched donors, the cost, and the risk of complications.

In the studies, the researchers goal is to functionally cure the blood disorders using CRISPR/Cas9 gene-editing by increasing the production of fetal hemoglobin, which produces normal, healthy red blood cells as opposed to the misshapen cells produced by faulty hemoglobin in the bodies of individuals with the disorders.

The clinical trials involve collecting stem cells from patients. Researchers edit the stem cells using CRISPR-Cas9 and infuse the gene-modified cells into the patients. Patients remain in the hospital for approximately one month following the infusion.

Prior to receiving their modified cells, the seven patients with beta-thalassemia required blood transfusions approximately every three to four weeks and the three patients with sickle cell disease suffered episodes of severe pain roughly every other month. All the individuals with beta-thalassemia have been transfusion independent since receiving the treatment, a period ranging between two and 18 months. Similarly, none of the individuals with SCD have experienced vaso-occlusive crises since CTX001 infusion. All patients showed a substantial and sustained increase in the production of fetal hemoglobin.

SafteyResearchers report that the safety of CTX001 infusion was generally consistent with the chemotherapy regimen received prior to cell infusion. Four serious adverse events related or possibly related to CTX001 were reported in one patient with thalassemia: headache, haemophagocytic lymphohistiocytosis (HLH), acute respiratory distress syndrome, and idiopathic pneumonia syndrome.

The patients have now recovered.

Unmet medical needThere is a great need to find new therapies for beta-thalassemia and sickle cell disease, said Haydar Frangoul, MD, Medical Director of Pediatric Hematology and Oncology at Sarah Cannon Research Institute, HCA Healthcares TriStar Centennial Medical Center.

What we have been able to do through this study is a tremendous achievement. By gene editing the patients own stem cells, we may have the potential to make this therapy an option for many patients facing these blood diseases, Frangoul concluded.

Because of the precise way CRISPR-Cas9 gene editing works, Frangoul suggested the technique could potentially cure or ameliorate a variety of diseases that have genetic origins.

Given that the only Food and Drug Administration (FDA) -approved cure for sickle cell disease, a bone marrow transplant, is not widely accessible, having another curative option would be life-changing for a large number of the sickle cell disease population, noted Catherine Bollard, MD, of Childrens National Research Institute and George Washington University.

While longer follow-up data are needed, this study is extremely exciting for the field, she added.

The trial was sponsored by CRISPR Therapeutics and Vertex Pharmaceuticals.

Abstract[1] Frangoul H, Bobruff Y, Cappellini MD, Corbacioglu S, Fernandez CM, De la Fuente J, Grupp SA, Handgretinger R, et al, Safety and Efficacy of CTX001 in Patients with Transfusion-Dependent - Thalassemia and Sickle Cell Disease: Early Results from the Climb THAL-111 and Climb SCD-121 Studies of Autologous CRISPR-CAS9Modified CD34+ Hematopoietic Stem and Progenitor Cells (Abstract #4)

Reference[2] Frangoul H, Altshuler D, Cappellini MD, Chen YS, Domm J, Eustace BK, Foell J, De la Fuente J, Grupp S, et al. CRISPR-Cas9 Gene Editing for Sickle Cell Disease and -ThalassemiaH. N Engl J Med. 2020 Dec 5; DOI: 10.1056/NEJMoa2031054[3] Heeney MM, Ware RE. Hydroxyurea for children with sickle cell disease. Hematol Oncol Clin North Am 2010;24:199-214.2.[4] Piel FB, Patil AP, Howes RE, et al. Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates. Lancet 2013; 381: 142-51[5] Esrick EB, Lehmann LE, Biffi A, Achebe M, Brendel C, Ciuculescu MF, Daley H, et al. Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease. N Engl J Med. 2020 Dec 5; DOI: 10.1056/NEJMoa2029392[6] Gluckman E, Cappelli B, Bernaudin F, et al. Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation. Blood 2017; 129: 1548-56.4.[7] Bernaudin F, Dalle J-H, Bories D, et al. Long-term event-free survival, chimerism and fertility outcomes in 234 patients with sickle-cell anemia younger than 30 years after myeloablative conditioning and matched-sibling transplantation in France. Haematologica 2020; 105: 91-101.

Featured image: The ASH Store at the American Society of Hematology 61th Annual Meeting at the Orange County Convention Center. Photo courtesy 2019. ASH/Scott Morgan. Used with permission.

Go here to see the original:
ASH 2020: Results from a Study of Inherited Blood Disorders Treated with CRISPR/Cas9 - OncoZine

Hematologic malignancy was associated with more severe symptoms and death from coronavirus disease 2019 (COVID-19), likely due to immunosuppression attributable to the hematologic disease, according to results of a retrospective study presented at the virtual 62nd American Society of Hematology (ASH) Annual Meeting and Exposition.

The worse disease evolution should be taken into account for a population that is highly exposed to SARS-CoV-2 contagion due to [a] high number of hospital visits for treatment, Cristina De Ramn, of the Hospital Universitario de Salamanca in Spain, and presenter of the study, said.

Prior studies have suggested that hematologic disease is associated with higher COVID-19 mortality rates than the general population, but the data so far are limited. The aim of this study, called ECOVIDEHE, was to assess the effect of hematologic disease and its associated treatment with the outcomes of COVID-19.

The multicenter, retrospective observational study evaluated data from 543 patients with hematologic disease who developed COVID-19 between March and June 2020. Samples and data were collected at the time of assistance in the emergency department or hospital admission.

At baseline, the median age of patients was 70 years, 57% of patients were male, and 76% had at least 1 comorbidity. There were 65% of patients in the cohort with a lymphoid malignancy, of which, 53.6% were on active anticancer treatment. SARS-CoV-2 infection was confirmed with a positive nasopharyngeal swab or serologic testing among 94% of patients, and 15% were nosocomial.

There were 89% of patients who required hospital admission, including 6.3% who were admitted to intensive care units (ICU). Overall, 65% of patients were considered to have severe COVID-19. The most common symptoms were fever, cough, dyspnea, and pneumonia.

Overall, the mortality rate was 36.3%. Patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS; 49%) were significantly more likely to die from COVID-19 than patients with other hematologic malignancies (34%) or other hemopathies (29%; P <.001). Patients with active or progressive disease were also more likely to die from COVID-19 (51%) compared with patients in complete remission (21%) or those with partial remission or stable disease (37%: P =.018).

Patients who had undergone an allogeneic (22%) or autologous hematopoietic stem cell transplant (20%) experienced improved survival compared with patients who had not undergone transplant (39%; P <.01). Ms De Ramn said that these findings may be because the patients who underwent transplant were younger and many were in complete remission.

In addition, mortality was associated with higher Charlson Comorbidity Index and Eastern Cooperative Oncology Group performance status. Mortality was also associated with low lymphocyte or platelet counts, as well as high lactate dehydrogenase, C-reactive protein, procalcitonin, and D-dimer levels. A multivariate analysis confirmed these findings, and also found that being older than 70 years was associated with mortality.

Most treatments for COVID-19 did not improve survival outcomes, except corticosteroids. Ms De Ramn suggested that this may be because the treatments were preferentially administered to patients with more severe disease.

Ms De Ramn concluded that SARS-CoV-2 infection causes more severe disease and higher mortality rates in hematological patients, especially those with AML/MDS or active or progressive disease.

Read more of Cancer Therapy Advisors coverage of the ASH 2020 meeting by visiting the conference page.

Reference

De Ramn C, Hernandez-Rivas JA, Garca JAR, et al. Impact of Sars-CoV2 infection on 491 hematological patients: the Ecovidehe Multicenter Study. Presented at: 62nd American Society of Hematology (ASH) Annual Meeting and Exposition; December 5-9, 2020. Abstract 312.

Read the original here:
Poor COVID-19 Outcomes Among Patients With Hematologic Malignancies: Results From ECOVIDEHE - Cancer Therapy Advisor

Ridding the world of Covid-19 is a lucrative enterprise.

As analysts divvy up the multibillion-dollar rewards in line for the leaders in the race to roll out the first pandemic vaccines, no one is forgetting to track just how much the top company founders have on the line now as stock prices gyrate ever higher.

Bloomberg, which tracks these numbers with missionary zeal, puts Sahins net worth today at $5.1 billion following the most recent rise of BioNTechs $BNTX share price. The biotechs partner, Pfizer, is aggressively pushing ahead with plans to get the first approved vaccine in play, and Bernstein believes that will put the two collaborators in line for the largest market share for next year.

Unlock this story instantly and join 94,800+ biopharma pros reading Endpoints daily and it's free.

SUBSCRIBE SIGN IN

Read the original post:
Backed by a $200M investment from a Korean conglomerate, Vivek Ramaswamy has quietly built a 'mother ship' for vant creation with a whole new...

Updated data for a second anti-BCMA therapy, idecabtagene vicleucel (ide-cel) from Bristol Myers Squibb/bluebird bio, will be presented, including health-related quality of life results from the KarMMA study in patients with heavily pretreated R/R multiple myeloma. FDA has assigned a March 27, 2021, target date for action on this therapy.

Also anticipated are results from the APOLLO study in relapsed multiple myeloma, which will show that adding daratumumab and hyaluronidase-finj, called Darzalex Faspro by Janssen, to pomalidomide and dexamethasone reduces the risk of disease progression or death by 37% compared with pomalidomide and dexamethasone alone.

Notably, this phase 3 study involves subcutaneous administration of daratumumab, which offers significantly reduced treatment time and burden for patients. Janssen has submitted results from APOLLO to FDA and the European regulators.

The subcutaneous formulation of daratumumab offers patients and physicians a 3- to 5-minute administration experience and the potential to reduce systemic administration-related reactions compared to intravenous administration of daratumumab, said Meletios A. Dimopoulos, MD, professor and chairman of the Department of Clinical Therapeutics at the National and Kapodistrian University of Athens School of Medicine, Athens, Greece, who is the studys principal investigator.

The REACH3 study, a phase 3 randomized study of ruxolitinib (Jakavi) vs best-available-therapy, will have important implications in chronic graft-vs-host-disease (GvHD). This condition occurs when new T cells from a stem cell transplant identify the patients cells as foreign and attack them, creating reactions from rashes to gastrointestinal issues to harm to the liver.

Results involving transplant in myelodysplatic syndromes (MDS) could have important implications for reimbursement. Corey Cutler, MD, MPH, FRCPC, of Dana-Farber Cancer Institute will present results that show transplantation of hematopoietic stem cells from compatible donors nearly doubled the survival rate of patients aged 50 to 75 years.

Even though transplant is frequently used in younger patients, it has not been widely used among older patients. Lack of Medicare coverage is a major barrier, Cutler explained. This study adds to a growing body of evidence that suggests its time to revisit the reimbursement question.

Asked his thoughts on whether CMS might change its policy, Cutler said, I cant speak for the agency, but I will tell you there are several studies that do suggest it should be covered.We are, of course, reaching out to CMS.

Fridays press briefing ahead of the opening of ASH highlighted the results for MDS and daratumumab and others that are expected to be practice changing. To know that older patients do well with transplant is a really important message, said Lisa Hicks, MD, MSc, a hematologist from St. Michaels Hospital in Canada, who moderated the briefing.

Ian Flinn, MD, of Tennessee Oncology, who is an author on several studies being presented at ASH involving venetoclax (Venclexta) and Brutons tyrosine kinase (BTK) inhibitors in chronic lymphocytic leukemia, said he was interested to see the results of the CAPTIVATE trial.

He said that right now, venetoclax is a fixed-duration therapy. Now, we need to figure out whether thats a good idea or not, Flinn said. CAPTIVATE will help clinicians understand whether they should keep patients on venetoclax plus ibrutinib after they have reached the point of minimal residual disease.

The ASH meeting will also highlight research examining disparities in care, as well as the effects of COVID-19 on outcomes. On Saturday, Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases (NIAID), will discuss the latest information on COVID-19 and its impact on hematologic conditions in a fireside chat with ASH President Stephanie J. Lee, MD, MPH.

This week, President-elect Joe Biden announced that Fauci will be a chief medical adviser, in addition to retaining his longtime role at NIAID during the new administration.

Maggie L. Shaw contributed to this report.

See the original post here:
ASH Goes Remote as CAR T-Cell Therapy Competition Heats Up - AJMC.com Managed Markets Network

Doctors at Vanderbilt Medical Center said people with diabetes should be prioritized for the COVID-19 vaccine.

NASHVILLE, Tenn. Doctors at Vanderbilt Medical Center say people with diabetes need to be prioritized for the COVID-19 vaccine. They also said there are certain side effects they need to be aware of.

Researchers at Vanderbilt said they studied more than 6,000 COVID-19 patients since March. They have compared the overall impact of the illness between those with Type 1 Diabetes, Type 2 Diabetes, and those who dont have Diabetes.

Researchers say 90% of Diabetic patients in the United States have Type 2 Diabetes. Around 10% (or 1.6 million people) have Type 1 Diabetes in the U.S.

They say while studies have suggested that those with Type 2 Diabetes are at higher risk for more serious complications and being hospitalized with COVID-19, little is known about the risk for individuals with Type 1 Diabetes.

Before we know it, we are going to have to decide which patients we need to prioritize to receive immunization for COVID-19, said Dr. Justin M. Gregory MD, MSCI.

Dr. Gregory not only researches how COVID-19 impacts Diabetic patients; he also lives with Type 1 Diabetes. Now, with a COVID-19 vaccine on its way, he says people with diabetes dont need to be the very first to get vaccinated.

Not above healthcare workers, not above people in nursing homes, but soon thereafter, Dr. Gregory said.

He said thats because those with Type 1 or Type 2 Diabetes are three times more likely to have a severe illness than those who dont have the medical condition. When it comes to getting the vaccine, they should expect certain side effects, including flu-like symptoms.

When people with Diabetes have flu-like symptoms, we know that makes their blood sugar levels go up, Dr. Gregory said. When people with Type 1 Diabetes and to some extent Type 2 Diabetes are getting these vaccines, they need to be positioning themselves and being really really on top of their diabetes control, as if they were sick.

He mentions that even though patients blood sugar might be more difficult to control a few days after, he still encourages them to get vaccinated.

Read the original here:
Vanderbilt doctors urge priority COVID-19 vaccination for Diabetic patients - WBIR.com

It has been known for some time that there is a reduction in the risk of type 2 diabetes for those who follow a Mediterranean diet. However, it has not been clear which factors are key to those beneficial effects.

While a reduction in body mass index (BMI) may be somewhat obvious, other mechanisms include beneficial effects on insulin resistance, lipoprotein metabolism and inflammation.

However, the diets antidiabetic effect does not appear to extend to people whose weight is considered healthy (BMI under 25), according to a recent study, which supports the idea that by improving their diet, people can improve their future risk of type 2 diabetes. This is particularly true if they are overweight or obese.

While metabolism can change over a short time on the Mediterranean diet, the study indicates that there are longer term changes happening that may provide protection over decades.

The Mediterranean diet, with an emphasis on healthy olive oil as the predominant source of oil, favors fruits, vegetables, legumes, nuts, and seeds, fish and dairy products, while limiting intake of red and processed meats as well as sweets.

The diet has been linked to as much as a 30% reduction in the risk of diabetes in previous observational studies.

To investigate the precise mechanisms that underlie the prevention of diabetes, the Harvard researchers examined data from 25,317 healthy women participating in the Womens Health Study who had baseline assessments between September 1992 and May 1995. They started out with an average age of 52.9 years.

Over the course of the study, 2,307 participants developed type 2 diabetes.

After a follow-up averaging almost 20 years, those who had the highest self-reported adherence to the Mediterranean diet (a score of 6 on a scale of 0 to 6) at baseline, had as much as a 30% lower risk of developing type 2 diabetes after some other factor adjustments compared to those with a lower Mediterranean diet score (a score of 3 or less).

The diabetes-related biomarkers that were most closely related to the reduced risk of type 2 diabetes included insulin resistance, accounting for 65% of the reduction, followed by BMI (55.5% reduction), high-density lipoprotein measures (53%), and inflammation (52.5%).

Other factors, though to a lesser degree, included branched-chain amino acids (34.5%), very low-density lipoprotein measures (32.0%), low-density lipoprotein measures (31.0%), blood pressure (29.0%), and apolipoproteins (23.5%).

Differences in glycohemoglobin A1c levels only had a limited effect on the risk (2%).

Further analysis looking at effects of the diet according to baseline BMI showed the reductions in type 2 diabetes associated with higher intake of the Mediterranean diet only extended to those with an above normal weight (BMI 25) as noted above.

The study was not originally designed to look at the baseline BMI as a factor. But the findings are consistent with the well-known increase in diabetes risk seen with a higher BMI.

Other studies, such as the Nurses Health Study, have shown that the risk for type 2 diabetes in women increases with age, even at BMI levels below 25. But the risk goes up exponentially at around a BMI of 25 and higher.

The strong role of insulin resistance was a surprise to the researchers. Since insulin resistance can precede by years and decades the elevated blood sugar and clinical diagnosis of diabetes, it could represent an opportunity to intervene earlier and more intensively by improving insulin resistance through dietary approaches such as the Mediterranean diet.

Another surprise was that glycohemoglobin A1c had no substantial effect on the reduction of diabetes risk with the Mediterranean diet. This could suggest that a rise in glycohemoglobin A1c likely occurs later in type 2 diabetes development.

Like every large population study, there are some limitations in what should be projected from the analysis results. But the findings suggest that more intensively following the Mediterranean diet might have substantial benefits over many years in preventing diabetes, among other health benefits such as lowering insulin resistance and inflammation, improving lipid metabolism, and lowering blood pressure.

Hopefully, more studies will help us understand the relationship. But for now, I would recommend that anyone who is overweight (especially with a family history of diabetes) may want to follow the Mediterranean diet.

More here:
Diabetes: Sunny news about food choices and better health - KPCnews.com

The holidays can be a magical time, but if you are a person with Diabetes, you might be worrying about controlling your blood sugar. This is a common thought, but the holidays dont have to be a time for throwing in the towel on all the hard work youve done the rest of the year.

Series 3 of the Fresh Focus Podcast was created by Marion VA Healthcare System Diabetes Educators to help you tackle the 2020 holidays.

We understand the holidays can also be a challenging time, especially with modifications this year, including smaller gatherings. This year, instead of making a large turkey, you might find yourself utilizing an herb roasted turkey breast instead. Similarly, you could try mini pumpkin pie-letsto reduce the overall calories and carbs while still getting your pie fix.

For people with Diabetes, when you choose to eat all of your calories and carbohydrates at one meal, you are taking a chance of having hypoglycemia or low blood sugar during the day. Then there is a possibility to have hyperglycemia or high blood sugar after eating too much that night with one large meal. Take a listen to the podcast to learn these key points in controlling a blood sugar roller coaster:

1. Eat consistently: dont skip meals during the day, which can lead to overeating at the big holiday meal.

2. Remember to always take your medications as ordered.

3. Utilize the healthy plate method even at the holidays to help fill your plate with all those good foods. Bring a delicious holiday inspired salad to the meal for a pop of green and bright red.

Now that you have your game plan, stay tuned for more Diabetes inclusive holiday eating tips. We hope you have happy, healthy holidays!

Kerri Hayden is a Registered Dietitian Nutritionist, Certified Diabetes Care and Education Specialist

Read the original here:
Fresh Focus #13: Taste of the Holidays: Meal Planning with Diabetes - VAntage Point - VAntage Point Blog

- FreeStyle Libre 2 system continuously measures glucose data every minute with customizable, optional real-time alarms1to alert users when their glucose is high or low without scanning

- Now for children (ages 4 and older) and adults with diabetes, this latest technology sustains excellent performance for up to 14 days, providing trends, insights and actionable data on a reader or with the FreeStyle LibreLink mobile app all at the same price as the current FreeStyle Libre system

- Latest sensor-based glucose monitoring technology will be available in the coming months to the more than 3.7 million Canadians with diabetes2

ABBOTT PARK, Ill., Dec. 2, 2020 /PRNewswire/ --Abbott (NYSE:ABT)today announced its next-generation, sensor-based glucose monitoring technology, FreeStyle Libre 2, received approval by Health Canada for adults and children (4 and older) with diabetes. With new features such as optional, real-time alarms1 that measure glucose levels every minute, FreeStyle Libre 2 gives users the option to be alerted in real-time of critical events such as hypoglycemia (low glucose levels3)or hyperglycemia (high glucose levels4). The wearable technology, which eliminates the need for painful fingersticks5, also provides people with diabetes with excellent accuracy and actionable information to better manage their condition, and will be priced at the same cost as the current FreeStyle Libre system.

"For the millions of Canadians with diabetes, Abbott's next-generation FreeStyle Libre 2 system expands on the life-changing capabilities of our original FreeStyle Libre system with enhanced accuracy, optional alarms and now available for children," said Marie-Flore Nabor, general manager of Abbott's diabetes care business in Canada. "This latest technology will transform the way diabetes is currently managed. The FreeStyle Libre 2 is designed to simplify this often complicated-to-manage condition and is accessible and affordable to people with diabetes in Canada."

How FreeStyle Libre 2 Works

As the world leader in sensor-based glucose monitoring,6Abbott continues to transform how people with diabetes test their glucose levels. Using Bluetooth technology, the FreeStyle Libre 2 system automatically alerts7users when their glucose is high or low without needing to scan the sensor.

The FreeStyle Libre 2 sensor is worn on the back of the upper arm for up to 14 days and measures glucose every minute to help users and their healthcare providers make informed treatment decisions. With a one-second scan using FreeStyle LibreLink, a smartphone app,8or handheld reader, users can see their glucose reading, trend arrow and eight-hour history. Users can also share data with their physicians or family members via the LibreLinkUp mobile app.

AbbottsFreeStyle Libre 2 system utilizes the same proprietary wired enzyme technology as the FreeStyle Libre system, which was the first to remove painful fingersticks5 and is associated with better glucose control9, decreased time in hypoglycemia and hyperglycemia10, more time in optimal glucose range7, and improved HbA1C11. A real-world study published in the British Medical Journal shows that the use of FreeStyle Libre system over one year is often associated with improved quality of life and that work absenteeism rate and diabetes-related hospital admissions decreased by two thirds.12

"Adding an alarm to this glucose sensing technology is definitely a major step to help people with diabetes live more confidently with less fear of high or low glucose levels," said Dr. Bruce Perkins, M.D., Director, Leadership Sinai Centre for Diabetes and Clinician-Scientist, University of Toronto. "We have seen from research with similar technologies that this kind of innovation can improve glucose level control, and even prevent emergency room visits and hospitalizations. For kids and adults alike, it means less pain from fingersticks, much greater insight into patterns, and much more reassurance."

AbbottsFreeStyle Libre 2 system will be available for people with diabetes ages 4 and up in Canada in the coming months.

As the #1 sensor-based glucose monitoring system used worldwide,6Abbott's FreeStyle Libre portfolio has changed the lives of more than 2.5 million people across more than 50 countries.Abbott has also secured partial or full reimbursement for the FreeStyle Libre system in 37 countries, including Canada where residents of Ontario and Quebec13who manage diabetes with insulin are covered. Other countries include France, Germany, Japan, the United Kingdom, and the U.S.

About Abbott Abbott is a global healthcare leader that helps people live more fully at all stages of life. Our portfolio of life-changing technologies spans the spectrum of healthcare, with leading businesses and products in diagnostics, medical devices, nutritionals and branded generic medicines. Our 107,000 colleagues serve people in more than 160 countries.

Connect with us at http://www.abbott.com, on LinkedIn at http://www.linkedin.com/company/abbott-/, on Facebook at http://www.facebook.com/Abbottand on Twitter@AbbottNews.

1Notifications will only be received when alarms are turned on and the sensor is within 20 feet of the reading device.

2Diabetes Canada. https://diabetes.ca/DiabetesCanadaWebsite/media/Advocacy-and-Policy/Backgrounder/2020_Backgrounder_Canada_English_FINAL.pdf. accessed November 24, 2020.

3FreeStyle Libre 2 User Manual. Based on low glucose alarms set at 70 mg/dl.

4FreeStyle Libre 2 User Manual. Based on high glucose alarms set at 180 mg/dl.

5A finger prick test using a blood glucose meter is required during times of rapidly changing glucose levels when interstitial fluid glucose levels may not accurately reflect blood glucose levels, or if hypoglycemia or impending hypoglycemia is reported by the system, or when symptoms do not match the system readings.

6 Data on file, Abbott Diabetes Care. Data based on the number of users worldwide for the FreeStyle Libre portfolio compared to the number of users for other leading personal use, sensor-based glucose monitoring systems.

7The FreeStyle Libre 2 system has optional glucose alarms. Alarms need to be turned on in order to receive low and high glucose alarms.

8The FreeStyle LibreLink app is only compatible with certain mobile devices and operating systems. Please check the website for more information about device compatibility before using the app. Use of FreeStyle LibreLink requires registration with LibreView.

9Dunn, T., et al. Real-world flash glucose monitoring patterns and associations between self-monitoring frequency and glycaemic measures: A European analysis of over 60 million glucose tests. Diabetes Research and Clinical Practice; 137(2018) 37-46

10Ajjan R. Insights from real world use of flash continuous glucose monitoring. Symposium conducted at: American Diabetes Association 78th Scientific Sessions; June 2018; Orlando, FL

11Seibold A, Ells S, Schlaeger C, Welsh Z. A meta-analysis of real-world observational studies on the impact of flash glucose monitoring on glycemic control as measured by HbA1c. Poster presented at: 78th Scientific Sessions; June 2018; Orlando, FL.

12FokkertM,van DijkP,EdensM, et al, Improved well-being and decreased disease burden after 1-year use of flash glucose monitoring (FLARE-NL4), BMJ Open Diabetes Research and Care2019;7:e000809.doi:10.1136/bmjdrc-2019-000809

13The following three criteria must be met: intensive insulin therapy, frequent or severe hypoglycemia problems and the necessity of glycemia self-monitoring a minimum of eight times per day.

SOURCE Abbott

http://www.abbott.com

Follow this link:
Abbott's FreeStyle Libre 2 Now Approved for Adults and Children with Diabetes in Canada, Featuring Unsurpassed 14-Day Accuracy and Optional Alarms -...

New Delhi | Updated: December 7, 2020 10:26:46 am

Written by Ambrish Mithal

There are no established easy solutions to mitigate . While the world is battling the pandemic together, the graveness of the situation is felt more in countries such as India that simultaneously have a high burden of non-communicable diseases (NCDs) to tackle. Reports have revealed that people with pre-existing medical conditions such as diabetes, heart disease and kidney problems are more vulnerable to becoming severely ill with COVID-19 virus. And India, known as the diabetes capital of the world, has one in six people with diabetes. With an estimated 77 million diabetics, the ninth edition of the IDF Diabetes Atlas projected that India would continue to be at the second spot among the top 10 countries with diabetes till 2045.

As the alarming statistics of people with diabetes continue to rise across the country and the world, the role of nurses and healthcare professionals (who account for over half of the global health workforce) has become increasingly important in managing the impact of the disease. Adherence to insulin and correct injection technique plays a vital role when it comes to managing diabetes. The role of the diabetes nurse in India is performed by the diabetes educator, whose background is usually nutrition. Nurses role in insulin administration and managing hypoglycaemia is largely in the hospitalised patient, where it is very important too. Hence, the ward nurses require training on all aspects of insulin storage and administration technique. OPD is usually taken care of by diabetes educators/nutritionists.

Governments and healthcare industry must recognise the importance of investing in educating and training frontline workers who can make a huge difference in the lives of people with diabetes. Besides counselling patients with diabetes, nurses and diabetes educators can also guide them about the complications associated with incorrect injection technique, reuse of needles and wrong insulin storage. Therefore, there is a need to acknowledge how nurses as well as diabetes educators make a difference in managing diabetes.

Due to lack of awareness and training on the correct injection practices, a significant proportion of people reuse insulin pens and syringe needles that are intended for single use only. Reuse of the needle causes bending and blunting of the needle tip, increasing bleeding, pain, dosage inaccuracy and the chances of lipohypertrophy which is a thickened, rubbery swelling under the skin that develops under the usual injection site. Lipohypertrophy can lead to poor glycaemic control, hypoglycaemia, and glycaemic variability. Studies show that the frequency of needle re-use, significantly increase the risks of developing lipo., Moreover, used needles are prone to contamination by bacteria. At times, macroscopic blood regurgitation into a cartridge is also observed. In this case, if the needle is reused, it could lead to transmission of blood-borne infections.

Along with proper injecting guidance, it is imperative to know that insulin should be stored under favourable conditions. When exposed to extreme heat or cold, Insulin loses its ability to control the blood sugar. Unopened insulin should be stored in the refrigerator (2-8 degrees C) and once opened, a vial can be stored at a room temperature of around 15-25 degrees C or in the refrigerator (2-8 degrees C) for up to 28 days.

Now that we know how to store insulin and choose the right site for injecting insulin, here are a few other things to keep in mind if you have diabetes. Ensure that you do not use expired insulin as that may no longer be sterile and will likely not provide the expected outcome. As insulin needs to be given at room temperature, it is recommended to take it out from the refrigerator 30 minutes before the injection. Before injecting yourself, wash your hands properly with soap. After ensuring there are no bubbles in the syringe, draw the right dose of insulin. Push the needle into the skin while holding a skin-fold, inject slowly and steadily until it is all in and leave it in place for at least 10 seconds after injecting. Release the skin-fold after removing the needle from the skin.

Adherence to accurate medication is a major factor in determining treatment outcomes for people living with diabetes. At a time when the world is already grappling with COVID-19, patients with diabetes on insulin need to be all the more careful about managing their condition optimally. There is a need to educate patients and their families about the disadvantages related to inappropriate insulin injecting practice and to push patients to consult diabetes educators in case of any complications.

(The writer is chairman & head (endocrinology and diabetology), Max Healthcare)

The Indian Express is now on Telegram. Click here to join our channel (@indianexpress) and stay updated with the latest headlines

For all the latest Opinion News, download Indian Express App.

Go here to read the rest:
The diabetes nurse in Covid times - The Indian Express

Global Chiropody & Podiatry Market: Snapshot

Escalating number of sport injuries and diabetes patients is likely to generate promising demand opportunities in the global chiropody & podiatry market during the tenure of 2020 to 2030. Physiotherapy and surgery practices are two types of services available in the market for chiropody & podiatry.

An upcoming research report by Transparency Market Research on the chiropody & podiatry market intends to give inclusive analysis of drivers, trends, challenges, restraints, threats, and opportunities in this market. Moving forward, this report delivers reliable data on shares, volume, and revenues of the market for chiropody & podiatry. Thus, the study works as a helpful tool to gain complete synopsis of the chiropody & podiatry market for the forecast period of 2020 to 2030.

The study performs segmentation of the global chiropody & podiatry market based on many important parameters such as type, application, and region. Based on application, the market for chiropody & podiatry is classified into hospitals, clinics, and others.

Request Brochure of Report - https://www.transparencymarketresearch.com/sample/sample.php?flag=B&rep_id=80235

Global Chiropody & Podiatry Market: Growth Dynamics

The global chiropody & podiatry market is all set to trace prodigious curve of expansion during the period of forthcoming years. This growth is attributed to plethora of factors. Chiropody and podiatry refer to healthcare services that are used in the treatment of numerous health issues including ingrowing toenails and thickened toenails, dry skin, calluses, corns, verrucae, cracked heels, ulcers, blisters, arthritic foot care, and diabetes. Thus, increased number of all these health issues is likely to fuel the demand opportunities in the chiropody & podiatry market in the upcoming years.

The chiropody & podiatry market is estimated to experience promising sales opportunities on the back of increased cases of sports injuries. In addition to this, the increased number of older population living in all worldwide locations is one of the key factors stimulating growth opportunities for vendors operating in the market for chiropody & podiatry.

Request for Analysis of COVID-19 Impact on Chiropody & Podiatry Market - https://www.transparencymarketresearch.com/sample/sample.php?flag=covid19&rep_id=80235

Global Chiropody & Podiatry Market: Competitive Analysis

The global chiropody & podiatry market experiences presence of quite considerable number of active players. As a result, the competitive landscape of the market for chiropody & podiatry is moderately intense. Vendors working in this market are using diverse strategies to gain the leading position.

Some of the key strategies executed by players in the chiropody & podiatry market include partnerships, mergers, acquisitions, joint ventures, product launches, and collaborations. Apart from this, many companies working in this market are increasing investments in research and development activities. This move is helping vendors to improve the services they offer. Owing to all these activities, the global chiropody & podiatry market is likely to develop at moderate pace during 20202030.

Pre Book Chiropody & Podiatry Market Report at https://www.transparencymarketresearch.com/checkout.php?rep_id=80235&ltype=S

The research report profiles key players working in the global chiropody & podiatry market. The list of important players in this market includes:

Read more information here:

https://www.transparencymarketresearch.com/chiropody-podiatry-market.html

Global Chiropody & Podiatry Market: Regional Assessment

In terms of region, the global chiropody & podiatry market shows existence in many regions including Europe, Latin America, North America, Asia Pacific, and the Middle East and Africa. Of all regions, Europe and North America are major regions in the market for chiropody & podiatry. This growth can be attributed to increased older population and increased instances of sports injuries in these regions. Apart from this, the market for chiropody & podiatry is likely to witness prodigious expansion opportunities in Asia Pacific. This growth is attributed to increased number of people living with diabetes.

About Us

Transparency Market Research is a next-generation market intelligence provider, offering fact-based solutions to business leaders, consultants, and strategy professionals.

Our reports are single-point solutions for businesses to grow, evolve, and mature. Our real-time data collection methods along with ability to track more than one million high growth niche products are aligned with your aims. The detailed and proprietary statistical models used by our analysts offer insights for making right decision in the shortest span of time. For organizations that require specific but comprehensive information we offer customized solutions through ad hoc reports. These requests are delivered with the perfect combination of right sense of fact-oriented problem solving methodologies and leveraging existing data repositories.

TMR believes that unison of solutions for clients-specific problems with right methodology of research is the key to help enterprises reach right decision.

Contact

Mr. Rohit BhiseyTransparency Market Research

State Tower,

90 State Street,

Suite 700,

Albany NY - 12207

United States

USA - Canada Toll Free: 866-552-3453

Email: sales@transparencymarketresearch.com

Website: https://www.transparencymarketresearch.com/

Read the original post:
Chiropody & Podiatry Market: Escalating number of sport injuries and diabetes patients is likely to generate promising demand opportunities -...

Diabetes type 2: Dr Zoe Williams discusses high blood sugar risks

Type 2 diabetes is a chronic condition whereby the pancreas does not release enough insulin to regulate blood sugar or the insulin it does produce is not absorbed by the cells. Blood sugar is the main type of sugar found in blood. It performs important functions in the body but it must be regulated - unconstrained blood sugar levels can inflict permanent damage to parts of the body such as the eyes, nerves, kidneys and blood vessels.

Stripped of the regulating hormone insulin, a person with type 2 diabetes must make healthy dietary decisions to control blood sugar levels.

Carbohydrates that rank high on the glycemic Index (GI) - a relative ranking of carbohydrate in foods according to how they affect blood glucose levels - are to be avoided or eaten in moderation.

High GI carbs are broken down quickly by the body and therefore raise blood sugar levels quickly.

White bread ranks high on the glycemic index so it is best to swap it for brown bread, which causes a slower rise in blood sugar levels.

READ MORE:Type 2 diabetes warning - four fruits that could be raising your blood sugar levels

However, you should inspect the packaging of brown bread products before purchasing because "a lot of brown bread is just colour-dyed white bread", according to Dr Michael Mosley, founder of The Fast 800.

As he explains to the Express.co.uk, these colour-dyed culprits often contain more sugar to make them more palatable.

"You have to read the side of the packet. If it is dense brown bread, rye, things with seeds or nuts in it there's a good chance it's okay. But often they've just processed it, so be cautious."

Dr Mosley added: "Id switch instead to quinoa, bulgur (cracked wheat), whole rye, whole-grain barley, wild rice and buckwheat.

DON'T MISSHow to live longer: Lifting weights for less than an hour a week could boost longevity[TIPS]How to live longer: The amount of tea you should drink a day to reduce your dementia risk[ADVICE]Bowel cancer symptoms: Five common signs of the deadly disease that may develop first[INSIGHT]

According to Dr Mosley, other healthy swaps include opting for lentils, beans, quinoa, wild rice and buckwheat over white pasta and white rice.

"The complex carbohydrates contain more fibre which supports the growth of friendly bacteria in your gut," he explains.

Dr Mosley says to completely cut back on cakes, sweets, biscuits, crisps, fruit juices and soft drinks.

"These foods rapidly turn into sugar in your blood causing sugar spikes and weight gain - they are like the tip of the iceberg," he warns.

In addition to modifying your diet, exercising regularly is integral to blood sugar control.

According to Diabetes UK, there isnt one type of activity thats best for everyone with diabetes.

Its about finding what works for you and depends on lots of things, like what you enjoy, where you are and how much time you have.

"Its best to do a mixture of different types of activity, because different types have different benefits. And doing the same thing can get boring after a while," the health body advises.

Many people have type 2 diabetes without realising - this is because symptoms do not necessarily make you feel unwell.

Symptoms of type 2 diabetes include:

According to the NHS, you should see your GP if you have any of the symptoms of type 2 diabetes or you're worried you may have a higher risk of getting type 2 diabetes.

As it points out, the earlier diabetes is diagnosed and treatment started, the better.

Original post:
Type 2 diabetes warning: The 'so-called' brown bread that could be raising blood sugar - Express

This article was originally published here

Cureus. 2020 Oct 31;12(10):e11278. doi: 10.7759/cureus.11278.

ABSTRACT

BACKGROUND: Glycated haemoglobin (HbA1c) is a marker that reflects the control of diabetes mellitus (DM) over a three-month period. We sought to compare cardiovascular outcomes of diabetic patients with and without controlled levels of HbA1c post percutaneous coronary intervention (PCI) presenting to King Faisal Cardiac Center. Methods: A retrospective single-center study of all patients with type two DM who were treated with PCI during the period between January 2015 and January 2018. All data were obtained from health informatics system. Demographics, clinical data, and major adverse cardiovascular and cerebrovascular events (MACCE) were collected to compare outcomes among diabetic patients with and without controlled HbA1c.

RESULTS: The study included 177 patients with type two DM who underwent PCI. The mean age was 63.3 (SD12). Males represented 73.4% and 26.6% were females. The mean HbA1c on admission was 8.7%. At presentation 31% of the patients had relatively controlled blood sugar (HbA1c mean 7.5%, SD0.5) and 69% presented with poorly controlled type two DM (mean HbA1c 9.1%, SD0.25). The prevalence of hypertension and dyslipidaemia were higher among the uncontrolled group, but there were no differences between both groups in the control of blood pressure or dyslipidaemia. Patients in the uncontrolled group had higher rate of prior PCI (36.6%) compared to the controlled arm (16%, p=0.0195) The prevalence of cerebrovascular, cardiovascular, and renal impairment was similar. The use of insulin was higher among the uncontrolled arm. Patients in the controlled arm had lower incidence of composite endpoints of death and non-fatal myocardial infarction and stroke (MACCE) (14% vs 41%, p=0.001) compared to the uncontrolled arm.

CONCLUSION: Among patients with type two DM that were treated with PCI, achieving targets of blood sugar control reflected by glycated haemoglobin is associated with improved survival and lower incidence of composite MACCE.

PMID:33274153 | PMC:PMC7707909 | DOI:10.7759/cureus.11278

Continue reading here:
Glycated Haemoglobin and Outcomes of Percutaneous Coronary Intervention Among Type Two Diabetic Patients in Saudi Arabia - DocWire News

Good nutrition is a critical part of health and development. According to the World Health Organization (WHO), better nutrition is related to improved health at all ages, a lower risk of diseases, and longevity.

People can find it difficult or confusing to navigate the amount of nutrition information now available, and many sources have differing views.

This article offers science-based nutrition tips to help someone lead a healthier lifestyle.

Following these nutrition tips will help a person make healthy food choices.

Including some protein with every meal can help balance blood sugar.

Some studies suggest higher protein diets can be beneficial for type 2 diabetes.

Other research indicates balancing blood sugar can support weight management and cardiovascular health.

According to research, omega-3 fatty acids in oily fish are essential for cell signaling, gene expression, and brain and eye development.

Some studies indicate that omega-3 fatty acids can reduce the risk of cardiovascular disease.

Other research suggests the anti-inflammatory properties of omega-3 may effectively manage the early stages of degenerative diseases such as Alzheimers disease and Parkinsons disease.

The American Heart Association (AHA) recommend people eat whole grains rather than refined grains.

Whole grains contain nutrients such as B vitamins, iron, and fiber. These nutrients are essential for body functions that include carrying oxygen in the blood, regulating the immune system, and balancing blood sugar.

The saying eat a rainbow helps remind people to eat different colored fruits and vegetables.

Varying the color of plant foods means that someone gets a wide variety of antioxidants beneficial to health, for example, carotenoids and anthocyanins.

Dark green leafy vegetables are a great source of nutrition, according to the Department of Agriculture (USDA).

Leafy greens are rich in vitamins, minerals, and antioxidants.

The USDA suggest that folate in leafy greens may help protect against cancer, while vitamin K helps prevent osteoporosis.

People should limit their intake of saturated fats while avoiding trans fats, according to the USDA.

A person can replace these fats with unsaturated fats, which they can find in foods such as avocado, oily fish, and vegetable oils.

As part of the Mediterranean diet, extra virgin olive oil has benefits to the heart, blood pressure, and weight, according to a 2018 health report.

A person can include extra virgin olive oil in their diet by adding it to salads or vegetables or cooking food at low temperatures.

According to the AHA, eating one serving of nuts daily in place of red or processed meat, french fries, or dessert may benefit health and prevent long-term weight gain.

The AHA suggest that Brazil nuts, in particular, may help someone feel fuller and stabilize their blood sugar.

According to the AHA, fiber can help improve blood cholesterol levels and lower the risk of heart disease, obesity, and type 2 diabetes.

People can get enough fiber in their diet by eating whole grains, vegetables, beans, and pulses.

Research suggests that plant-based diets may help prevent overweight and obesity. Doctors associate obesity with many diseases.

According to some studies, including more plant foods in the diet could reduce the risk of developing diseases such as diabetes and cardiovascular disease.

Beans and pulses are a good source of protein for people on a plant-based diet. However, those who eat meat can eat them on a few meat-free days a week.

Beans and pulses also contain beneficial fiber, vitamins, and minerals.

Some research even says pulses may help people feel fuller and lose weight.

Drinking plenty of healthy fluids has numerous health benefits. Health experts recommend these tips:

Drinking enough water every day is good for overall health and can help manage body weight, according to the Centers for Disease Control and Prevention (CDC).

Drinking water can prevent dehydration, which can be a particular risk for older adults.

If someone does not like plain water, they can add some citrus slices and mint leaves to increase the appeal, or drink herbal teas.

A 2017 study suggests that moderate coffee consumption of 35 cups a day can reduce the risk of:

According to the same review, the recommended amount reduces to 2 cups per day for pregnant and lactating people.

According to research, catechins in green, black, and other herbal teas may have antimicrobial properties.

Herbal teas, such as mint, chamomile, and rooibos, are caffeine-free and help keep someone hydrated throughout the day.

It is important to cut back on food and drink that may have harmful health consequences. For example, a person may want to:

According to research, dietary sugar, dextrose, and high fructose corn syrup may increase the risk of cardiovascular disease and metabolic syndrome.

People should look out for hidden sugars in foods that manufacturers label as names ending in -ose, for example, fructose, sucrose, and glucose.

Natural sugars, such as honey and maple syrup, could also contribute to weight gain if someone eats them too often.

Dietary Guidelines For Americans recommend that if someone consumes alcohol, it should be in moderation.

They advise up to one drink per day for females and up to two drinks per day for males.

Excessive drinking increases the risk of chronic diseases and violence, and over time, can impair short and long-term cognitive function.

The CDC associate frequently drinking sugary drinks with:

People should limit their consumption of sugary drinks and preferably drink water instead.

A large prospective study in the British Medical Journal indicates that U.S. adults eating more red and processed meat had higher mortality rates.

Participants who swapped meat for other protein sources, such as fish, nuts, and eggs, had a lower risk of death in the eight-year study period.

According to a review in Nutrients, eating ultra-processed foods can increase the risk of many diseases, including cancer, irritable bowel syndrome, and depression.

People should instead consume whole foods and avoid foods with long lists of processed ingredients.

There are several steps a person can take to improve their health in addition to consuming healthful foods and drinks.

A 2019 review in Nutrients suggests that a high quality, balanced diet supports microbial diversity and can influence the risk of chronic diseases.

The authors indicate that including vegetables and fiber are beneficial to the microbiome. Conversely, eating too many refined carbohydrates and sugars is detrimental.

The recommended dietary allowance for vitamin D is 15 micrograms or 600 international units per day for adults.

Many people get some of their vitamin D from sunlight, while it is also in some foods.

People with darker skin, older adults, and those who get less exposure to sunlight such as during winter or in less sunny climates may need to take a vitamin D supplement.

Being aware of portion sizes can help people manage their weight and diet.

The USDA have helpful information about portion sizes for different food patterns.

People can adapt the guidelines to suit their cultural or personal preferences.

Using herbs and spices in cooking can liven up a meal and have additional health benefits.

A 2019 review suggests that the active compounds in ginger may help prevent oxidative stress and inflammation that occurs as part of aging.

Curcumin in turmeric is anti-inflammatory and may have protective effects on health, according to research.

Garlic has many benefits, including anti-inflammatory, antimicrobial, and antioxidant properties.

Intermittent fasting involves not eating either overnight or some days of the week. This may reduce energy intake and can have health benefits.

According to a 2020 review, intermittent fasting may improve blood pressure, cholesterol levels, and heart health.

The American Society for Nutrition say that keeping a food journal can help people track calories, see how much they are eating, and recognize food habits.

Keeping a food journal could help someone who wants to maintain a moderate weight or eat a more healthful diet.

Apps, such as MyFitnessPal, can also help someone achieve their goals.

Raw fruits and vegetables can contain harmful germs that could make someone sick, according to the CDC. They advise that Salmonella, E.coli, and listeria cause a large percentage of U.S. foodborne illness.

Always wash fresh produce when eating them raw.

Research suggests that microwaving food in plastic containers can release phthalates, which can disrupt hormones.

Experts recommend heating food in glass or ceramic containers that are microwave-safe.

Many people eat the same meals regularly. Varying foods and trying different cuisines can help someone achieve their required nutrient intake.

This can be particularly helpful when trying to eat a broader range of vegetables or protein.

In a 2017 study, mindful eating helped adults with obesity eat fewer sweets and manage their blood glucose.

Another study suggests mindfulness can bring greater awareness to food triggers and habits in people with diabetes.

Nutrition is an essential part of health, and people can start leading a healthful lifestyle by making small changes to their diet.

It is also important to remember other key aspects of health, such as exercise and activity, stress strategies, and adequate sleep.

Originally posted here:
29 nutrition tips to improve health for everyone - Medical News Today

A new study has found elderly men with existing cardiometabolic disease with a version of a gene associated with longevity and aging in humans appeared to have a reduced risk of death.

The gene in question, Forkhead Box O3 (FOXO3) has long been highlighted in the past as being important in the aging process.

Chronic cardiometabolic diseases of aging such as diabetes, heart disease, and high blood pressure increases the risk of death and a shorter lifespan.

The study followed 3,584 men from the Kuakini Honolulu Heart Program in Honolulu, Hawaii, to examine the effects of the longevity version (alleles) of the FOXO3 gene in men with cardiometabolic diseases and found they lived just as long as men who did not have the disease.

The findings were presented in a paper published in Aging

The work was conducted by an international team, including researchers at the University of Sydney and the University of Hawaii.

Emeritus Professor Brian Morris from the Faculty of Medicine and Health, University of Sydney was corresponding author on the paper.

We have found for the first time that the remaining lifespan of elderly men with longevity associated alleles (versions) of FOXO3 who have one of more chronic conditions of ageing, such as diabetes and hypertension live as long as elderly men who lack any of these lifethreatening conditions, says Emeritus Professor Morris.

This suggests that expression of this particular version of FOXO3 in humans appears to impact what would otherwise be an increased risk for mortality in men with prevalent cardiometabolic conditions.

More:
Longevity gene could be key in reducing risk of death for men with chronic disease - News - The University of Sydney

With a year which has shook many to their cores, putting your health as a priority has never been more important. By quitting smoking, avoiding binge drinking, finding healthy hobbies which bring you joy and eating a varied diet rich in fruits and vegetables you could help boost your longevity by a whopping 10 years.

In a study published in the US National Library of Medicine National Institutes of Health, a Mediterranean diet for an added 10-year mortality in elderly European men and woman was investigated.

The study noted: Dietary patterns and lifestyle factors are associated with mortality from all causes, coronary heart disease, cardiovascular diseases, and cancer, but few studies have investigated these factors in combination.

The study included 1507 apparently healthy men and 832 women, aged 70 to 90 years in 11 European countries.

The study found that by making healthier choices and following a more varied diet including the Mediterranean diet, premature death risk was lowered, as well as a reduced risk of cancer, metabolic syndrome, heart disease, depression and brain deterioration.

READ MORE:Best supplements for the heart - the 2p capsules to protect against heart disease

We are all aware of how binge drinking can negatively affect not only our physical health but our mental health too.

With the Christmas season in full swing its easy to be over drinking, however, heavy alcohol consumption is linked to liver, heart, and pancreatic disease, as well as an overall increased risk of early death.

Moderate alcohol consumption is associated with a reduced likelihood of several diseases, as well as a 17 to 18 percent decrease in your risk of premature death.

To keep consumption moderate, it is recommended that women aim for one to two units or less per day and a maximum of seven per week.

Men should keep their daily intake to less than three units, with a maximum of 14 per week.

Its a no brainer that cigarette smoking is linked to a number of serious health conditions including cancers and diseases.

A study looked at the 21st century hazards of smoking and benefits of stopping.

Interesting the study found that among UK women, two-thirds of all deaths of smokers in their 50s, 60s, and 70s are caused by smoking; smokers lose at least 10 years of lifespan.

Although the hazards of smoking until age 40 years and then stopping are substantial, the hazards of continuing are ten times greater.

Stopping before age 40 years (and preferably well before age 40 years) avoids more than 90 percent of the excess mortality caused by continuing smoking; stopping before age 30 years avoids more than 97 percent of it.

View post:
How to live longer: Four habits to implement in your life to boost longevity by 10 years - Express

About eighty per cent of our longevity and health is determined by our epigenome and by not our DNA and we can change our epigenome by how we live, Dr David Andrew Sinclair, professor of genetics and co-director of the Paul F Glenn Center for the Biology of Aging Research at Harvard Medical School, told Hindustan Times health editor, Sanchita Sharma on Friday.

Dr Sinclair talked about some minor dietary and lifestyle tweaks that can turn on the bodys defences against ageing and help promote longevity and good health.

He said that eating three regular meals a day will not give the best results for longevity, instead, skip a meal in a day.

What I do is that I skip a meal in a day and I try not to snack but have tea or coffee, he said.

Dr Sinclair however said that young people should not skip a meal, older and middle-aged people can skip a meal in a day.

Also read: With Covid-19 vaccine coming, economic recovery will gain traction - FM

Dont skip breakfast, may skip lunch or dinner depending on the individual, this is for middle-aged or older people who have slightly slower metabolism, he said, adding that he isnt promoting starvation.

Dr Sinclair explained that longevity factors get turned on when a person remains hungry for a brief spell. If we sit around the whole day, keep eating and dont feel hungry, our bodies will relax and stop fighting ageing, he explained.

He also discussed some other ways to turn on the bodys defences against ageing:

Lose your breath from exercise.

Do hip-hinges exercises, weight-lifting. Keep your hips strong.

Use biomarker feedback. Monitor your health level, track your vitals and see hows the body performing on a daily basis.

Sleep well and reduce stress.

Eat plants that have been stressed, for example, wine is made from grapes that have been stressed.

Dr Sinclair appeared on the cover of the Time Magazines 100 most influential people in the world. Besides Sinclair, the sixth day of HTLS 2020 saw Union finance minister Nirmala Sitharaman and YOOX Net-a-Porter Groups Federico Marchetti in participation.

Read more:
Skip a meal: Harvard expert Dr Sinclairs tips on how to live healthy, longer - Hindustan Times

Getty Images

Davante Adams saw on social media last week that Aaron Rodgers needed three touchdowns to hit 400 for his career. Adams caught the first; Robert Tonyan caught the second; and after Adams caught the third, he presented the ball to the Packers quarterback.

Yeah, that was a special moment, Rodgers said. I can remember all the hundred notches. I said after the game in an interview this will be the first out of those that I actually probably will get the ball. . . . [The receivers] didnt say a whole lot during the week. Its always interesting to see who gets the milestone throw. It was pretty cool that Davante got it. I didnt do a whole lot on that play. It was a really good scheme and play. He did the whole thing and stiff-armed his way into the end zone.

Its fun to have those milestones in back-to-back weeks. Like I said last week, a lot of it is longevity, but there also is some consistent play tied to it.

Rodgers became the fastest quarterback ever to reach 400 career passing touchdowns, and the seventh ever to hit the milestone.

Buccaneers quarterback Tom Brady is the all-time leader with 569 touchdown passes and counting with Saints quarterback Drew Brees on injured reserve with 565.

Rodgers last week became the 11th player in NFL history to reach 50,000 career passing yards.

View original post here:
Aaron Rodgers sets another milestone with 400th career touchdown - NBC Sports - NFL

Lockdown 2.0 might have lifted, at least in some places. But for those who want to wait for a vaccine before returning to the gym, and with jogging and cycling in the cold and wet an altogether grimmer prospect than it was in March, it is no wonder that online sales of home exercise equipment have rocketed.

According to figures released by eBay last month, sales of strength and weight training equipment shot up by 500 per cent after the autumn restrictions were announced, while cardio machine sales rose by 200 per cent. Rather than flour, this time panic buyers stocked up early on dumb-bells and yoga mats. And as Christmas approaches, retailers are banking on a bumper year.

Nothing illustrates just how fit-kit crazy weve become these past weeks than the fact that, on Amazon, a device called the OOTO Upgraded Boxing Reflex Ball is now a bestseller. It is, essentially, a ball on a string, attached to a headband and swatted by the user, like an oversized cat toy. Bizarre, but popular, if you believe the sales algorithms.

Purchasing home exercise kit can be bewildering and expensive, as any Peloton owner will tell you. Which is why I tested a range of more affordable products that will likely find themselves on this years Christmas lists.

Read the rest here:
The best affordable fitness kit to help you work up a sweat indoors this winter - Telegraph.co.uk

Aspart of a study, scientists from Australian Institute of Marine Science in the Rowley Shoals have discovered an 81-year-old midnight snapper, which is considered to be the oldest tropical reef fish in the world. As per the study, Snappers are highly valued by the global fisheries. Also, they are a large component of catches of tropical and subtropical multispecies fishery and are often associated with other meso-predators such as epinephelids and lethrinid.

The research shows that the species of the genus Lutjanus have some of the greatest recorded longevity among tropical reef fishes, with maximum recorded ages of 55 years. Extended longevity is usually the trait of species that live in environments where recruitment success is highly variable and is thought to be a hedge-betting strategy. This ensures that recruitment events coincide with species that live in environments where recruitment success is highly variable and is thought to be a hedge-betting strategy. The study focusses onthree species that are not targeted by fishing in the region: the red bass (Lutjanus bohar), midnight snapper (Macolor macularis), and black and white snapper (Macolor niger).

Read:Oral Drug Blocks Coronavirus Transmission In Ferrets Within 24 Hours: Study

Also, 10 other fishes, which were more than 60-year-old were identified in the Rowley Shoals in 1977. One of these 10 fishes was 79-year-old. The study says that exceptional longevity was discovered in all species. Also, corresponding patterns of age-based demography that varied predictably across latitude were observed. L. bohar and M. macularis were identified as the longest-lived reef-associated fishes from the tropics recorded to date, with a single L. bohar from the Rowley Shoals.

Read:China's Nonsensical Study Claiming COVID's Origin Is India Called Out; CSIR Tears It Apart

The study said, These estimates are two decades greater than that of any fish species from this environment ever recorded; overall, we recorded seven L. bohar and four M. macularis >_ 60 yrs .Published in the Journal named 'Coral Reefs', the research focusses onfour locations along the Western Australia coast, as well as the protected Chagos Archipelago in the central Indian Ocean. Thesnapper is thought to have been born in 1935. However, the elderly sea bass hatched during the First World War.

Read:Baby Goat Missing From Old 'Big Fish' Movie Set In Alabama

Also Read:AC Valhalla Guide: Learn How To Fish With The Help Of This AC Valhalla Fishing Guide

Visit link:
Worlds oldest tropical fish found in Australia survived WWII, can you guess its age? - Republic World