StemCell Therapy

If youve made it through 2020 without feeling stressed, congratsyoure a magician. For the rest of us, this tumultuous year has been trying enough to leave even the most positive of people looking for some support.

Since deep breaths and telling yourself to calm down only go so far, we asked Bindiya Gandhi, MD, whos double board-certified in family medicine and integrative medicine, to share her most impactful advice on how to actually managestress.

We are constantly exposed to stress, but our stress load is intensified because of the pandemic, Dr. Gandhi says. I encourage everyone to learn some techniques they can use later in life. My hope is after this pandemic is over, we will have become a stronger, more resilient society with better stress-management skills. Hows that for a positive outlook?

Dr. Gandhi says that some amounts of stress will always be normal (because life wont suddenly be worry-free once the calendar turns to 2021), but learning how to manage it is the key. From adjusting your diet and lifestyle to recommendations on the high-quality Solgar supplements to take, keep reading for the stress-less techniques you can implement ASAP.

Stress might make you want to down a whole box of cookies and a bottle of red, but turning to sugar, alcohol, or caffeine could actually make things worse, according to Dr. Gandhi.

When youre stressed, you usually experience a spike in the hormone cortisol, which can cause sugar cravings and sleep issues, she says. The trouble is, caffeine also increases cortisol, so its like throwing fuel on the fire: Youre stressed, so you dont sleep, so you drink coffee, which can increase your stress (and your sugar cravings), and the cycle repeats.

You might think a glass of wine would help break the cycle (alcohol makes people sleepy, right?), but Dr. Gandhi says think again. Alcohol disrupts your circadian rhythm and inhibits you from getting good, deep REM sleep, which is why its best to avoid when youre already feeling overwhelmed, she says. Instead, opt for some herbal tea and a savory snack during your wind-down time, and your sleep schedule (and your hormones) will thank you.

Yes, endorphins make people happy, but aside from the physical stress-relieving side effects of working out, adding more movement into your day gives you an opportunity to focus your energy on something positive, rather than dwelling on any negatives (looking at you, 2020).

Whether its a brisk walk in the park, a few yoga asanas, some lunges, or even training for a run, [routine] moderate exercises will decrease your cortisol production, help you sleep better at night, and elevate your mood, Dr. Gandhi says. Can you feel those endorphins already?

Dr. Gandhi is a big fan of using supplements to help with occasional stress, and often recommends them to her patients looking for support in facing less-than-stellar emotions.

If you want to stock your medicine cabinet with mood-supporting supplements, start with Solgar Stress & Anxiety Relief Tablets, which contain ashwagandha (an adaptogen that a 2012 study showed to support a healthy cortisol response) and saffron (which studies have shown can help maintain a positive mood).*

Some other heavy hitters in the stress-management game? Magnesium (which a 2017 review of 18 different studies showed can help with occasional anxiety), B vitamins, and 5-HTP.* Dr. Gandhi explains that 5-HTP is an amino acid thats a precursor to serotonin (the feel-good hormone), so it promotes a calm, relaxed mood.* The more you know.

Another of Dr. Gandhis go-tos for decreasing cortisol? Meditation. And regardless of what that looks like for you, anything from a quiet walk around the block (spending time outdoors is another big one on Dr. Gandhis list of chill-out techniques) to a full-on guided mediation session can help promote those feelings of calm youre after.

Taking time to implement silence for a few minutes a day goes a long way, Dr. Gandhi says. It changes the projection of your day and significantly decreases your cortisol production over the long term.

Now, you probably cant quit your job and move to a tropical island in the name of eliminating stress, but you can be intentional about scheduling time in your day to do things that make you happy.

Whether its reading, singing, or just playing with your dog, take a moment to take inventory of what makes you feel most joyfulthen find a way to do more of that thing every day, even if its just for five minutes. Heres to heading into 2021 with less stress, and more joy.

Photo: Getty/Westend61

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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Has 2020 Been Stressing You Out? Try This MDs 5 Tips for Finding More Calm - Well+Good

(Eds: Disclaimer: The following press release comes to you under an arrangement with Business Wire India. PTI takes no editorial responsibility for the same.) Mumbai, Maharashtra, India Business Wire India A wellness-focused virtual read aiming to bring the body in harmony with nature An insightful and inspiring read to modify your lifestyle in accordance with the circadian rhythm Second-in-line as a free book to the world emphasizing on holistic health and wellness Luke Coutinho, a globally renowned Holistic Lifestyle Coach and an expert in Integrative Medicine has recently launched his second e-book A New Way of Living as a free gift to India and the world. Being authored by the wellness aficionado himself, this book emphasizes the intelligence of our bodies in connection with nature.Lukes previous e-book The Magic Immunity Pill Lifestyle with Shilpa Shetty, that was also a free gift to the readers, has crossed 60k+ downloads since its launch and is a huge success across India and overseas. Joining the bandwagon of books on healthy lifestyle is - A New Way of Living, an e-book- that has already garnered over 50K+ downloads from all across the globe within the first hour of its release.The goal of the book is to highlight the importance of syncing your body''s internal clock - the circadian rhythm and also mentions guidelines to be followed for being in harmony with nature. This virtual read is insightful and inspiring as it has positive stories and feedbacks from people who have embraced this way of living and seen phenomenal changes in their health and well-being. The book gives you an insight on each of these guidelines, along with scientific explanations. Adding a non-fictional touch to the book is a chapter dedicated to night-shift workers who due to their jobs, struggle to live according to the circadian cycle.Through years of experience as a holistic lifestyle coach, Lukes proficiency as a wellness leader has provided him with transformational tools to assist people in making the necessary lifestyle modifications. A New Way of Living emphasizes on the significance of having a strong immunity and uses it as a catalyst to make lifestyle changes for living within the boundaries and laws of nature. Through this book, Luke encourages readers to make an effort to sync back the body that has been operating outside the laws of the nature.Lukes backend coaching complements each chapter of the book thus aiding the readers with transformational tools that will change their life.According to Luke Coutinho, Holistic Lifestyle Coach, Integrative Medicine, Through the launch of A New Way of Living, we aim to help masses regain their health in the most effortless ways by operating within the laws of nature. The outside environment that controls our inner setting is the bodys intelligence that exists in the trillions of cells present in our body. During and post-pandemic times, the way forward is to live according to the new way of living- circadian rhythm. This book is all about bringing our health and lifestyle in tandem with nature. We need to align all that we do, according to the circadian rhythm to help restore, regain and reset our health in a massive way.About Luke Coutinho Holistic Healing Systems Pvt. Ltd.Luke Coutinho Holistic Healing Systems Pvt. Ltd. focuses on integrative and preventative health care using lifestyle, with its team of medical doctors, nutritionists, clinical dietetics, emotional counsellors, lifestyle experts, yoga therapists, and elite trainers practising across the globe. Through personal consults and programs on health and wellness, condition management and supplementary cancer care, the integrative team works towards identifying the root cause of a particular health condition and helps people suffering from lifestyle-driven illnesses to reduce their pain and improve the quality of life. The Company has its main presence across India, Dubai, Middle East, Africa, the U.K., and the U.S. and its ecosystem includes building sustainable and healthy food chains across India.To View the Image Click on link Below:A New Way of Living - Circadian Rhythm PWRPWR

Disclaimer :- This story has not been edited by Outlook staff and is auto-generated from news agency feeds. Source: PTI

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Holistic Lifestyle Coach Luke Coutinho Launches a Free E-book - a New Way of Living, to Help Readers Discover the Wellness Route - Outlook India

Drive up for soup and sandwiches

The Oak Ridge Presbyterian Church north of Wellsville will offer carryout soup and sandwich from 4-6:30 p.m. Wednesday. There will be a variety of frozen soups in microwaveable containers, fresh bean soup and steak sandwiches. Donations will be accepted.

Church offering GriefShare support

Lake Mount Church of Christ, 6290 state Route 7, New Waterford, is hosting a loss of spouse seminar of GriefShare from 10 a.m. to noon Saturday, Dec. 5. GriefShare is a special seminar and support group designed to help you rebuild your life after losing a loved one. This group is led by caring people who have experienced grief and want to help you through the difficult days ahead. Cost of the program is $5 to cover workbook and materials. Social distancing will be in order. For additional information call the church office at 227-3636

Arthritis program

The Arthritis Foundation, a national, non-profit organization, announced a new Live Yes! Connect group has formed in Boardman. For now the program will be virtual for adults or parents of children living with arthritis. Deborah Andio, the new facilitator for the Boardman Live Yes! Connect group, said We want to get the word out that our support group is here, and we are planning our first virtual event. It will be held at 10 a.m. Dec. 12. Dr. Yufang Lin from the Cleveland Clinic Center for Integrative Medicine will be discussing the healing power of the human body. Discussion also will center on nutrition to help inflammation, discuss herbs and supplements as well as essential oils. The doctor will also share some recipes. The presentation is 45 minutes followed by a 15-minute Q and A. To sign up go to connectgroups.arthritis.org.

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Area briefings | News, Sports, Jobs - The Review - The Review

San Francisco, CA, December 1, 2020 Candied sweet potatoes. Egg nog. Mac n cheese. Stuffing. Pumpkin pie. Traditional holiday meals are resplendent with taste-of-home fare thats easy to overeat. Based on original research by holistic nutrition researcher Deborah Kesten, M.P.H., and behavioral scientist Larry Scherwitz, Ph.D., Whole Person Integrative Eating offers in-depth insights into the reasons we overeat and gain weight, and a science-backed, step-by-step dietary lifestyle that can halteven reverseovereating and weight gain during the holidaysand throughout the year.

Now is the time to reset and rethink what and how we eat; to replace traditional dieting with a scientifically sound way of eating thatlessens overeatingand that leads naturally to weight loss, health, and healing, says Kesten.

In their award-winning book, Whole Person Integrative Eating: A Breakthrough Dietary Lifestyle to Treat the Root Causes of Overeating, Overweight, and Obesity, authors Kesten and Scherwitz share a simple yet powerful premise: Identify the reasons you overeat (your overeating styles) and gain weightwith the illuminating self-assessment quizthen overcome overeating and lose weight by replacing your overeating styles with the antidotes: the elements of the Whole Person Integrative Eating program.

By shedding light on the root causes of overeating, Kesten and Scherwitz present a program that empowers readers with a personalized plan, and in turn new hope and new choices to help them reduce overeating, lose weight and keep it off.

WPIE is not a diet that a person goes on then off. It is a scientifically sound, dietary lifestyle designed to be practiced for a lifetime.

If people follow the revolutionary program outlined in this game-changing, insightful book, it may be the most helpful step they can take toward losing weight and keeping it off, says bestselling author Kenneth Pelletier, M.D., clinical professor of medicine at University of California School of Medicine, San Francisco.The authors paradigm-shifting message is that food influences not only the physical dimensions of health, but also our emotional, spiritual and social well-being. Their dietary lifestyle can build bridges between the millions who struggle with overeating and weight issues and the medical community. And it can inspire us all to re-envision our relationships with food, eating and weight, so that each time we eat, we are nourished for life.

Deborah Kesten, M.P.H., is an international nutrition researcher, award-winning author and medical/health writer, with a specialty in preventing and reversing obesity and heart disease. She served as Nutritionist on Dean Ornish, M.D.s first clinical trial for reversing heart disease through lifestyle changes, the results of which were published in the Journal of the American Medical Association. She has served as Director of Nutrition at cardiovascular clinics in Europe and on the Board of Directors of the American Heart Association, San Francisco.

Kesten has published more than 400 nutrition and health articles. Her first book, Feeding the Body, Nourishing the Soul, received the first-place gold award in the Spirituality category from the Independent Publisher Book Awards. Whole Person Integrative Eating has been honored with the No.1 gold, best-book award in the Health category by Book Excellence Awards and is a No. 1 Amazon best seller. Kesten is a VIP Contributor at Arianna Huffingtons Thrive Global, and is married to behavioral scientist and co-author of Whole Person Integrative Eating, Larry Scherwitz, Ph.D.

For more information, please visit http://www.IntegrativeEating.com. You can also connect with the author on the following social media sites: https://www.instagram.com/integrativeeating/;

https://www.facebook.com/WholePersonIntegrativeEating; https://twitter.com/IntegrativeEat1.

Whole Person Integrative Eating: A Breakthrough Dietary Lifestyle to Treat the Root Causes of Overeating, Overweight, and Obesity

Publisher: White River Press

ISBN-10: 1887043543

ISBN-13: 978-1887043540

Available from Amazon.com and integrativeeating.com

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Overcome OvereatingDuring the Holidays and Throughout the Year - Milwaukee Community Journal

David Sauro| COURTESY PHOTO

Third article of three-part series.

With the fight against COVID-19 for the past several months, we understand the importance of wearing a mask, washing your hands often and social distancing. Now that winter is here, we also need to take the necessary precautions to fight against the flu and the common cold, in addition to COVID. Medical experts also focus on the importance of boosting your immune system to give you the edge to stay healthy. It is more important than ever to make a commitment to a heathy lifestyle that will help to strengthen your immune system.

While there is no magic healthy pill, there are ways to make your immunity powers stronger. In our previous articles we talked about getting Vitamin D, and those "S" words, sleep, stress, and sugar. Getting enough quality sleep and reducing stress and sugar is necessary to enhance our immune system. This article will be on the importance of getting enough movement, proper nutrition, and hydration.

To move your body daily is a powerful way to boost your immune system. Regular exercise is one of the pillars for healthy living. It improves cardiovascular health, lowers blood pressure, helps control body weight, and protects against a variety of diseases. The benefit of an active body is good circulation, which allows blood cells and the lymph to move through the body freely and do their job effectively.

Being active causes your bodys antibodies and white blood cells to circulate more rapidly, which means they may be able to detect and zero in on illness more quickly. Being active also lowers stress hormones, which reduces your chances of getting sick, said Dr. Mark Moyad from the University of Michigan Medical Center. If you already have a regular exercise routine, keep it up. If you do not, try to move as often as you can throughout the day. The body functions better when physically active every day. A minimum of 10 minutes a day but ideally up to 30 minutes a day. Exercise is individual, so always listen to your body, and consult a physician or healthcare professional if making a major exercise change. Moderate exercise, such as brisk walking, jogging, swimming, yoga, and light hiking, can reduce inflammation and help your immune cells regenerate regularly. Exercise improves cardiovascular health, lowers blood pressure and helps control body weight. Like anything else, moderation is the key to exercise, finding that sweet spot that works for your body.

Diet is a big part of living a healthy lifestyle. Eighty percent of your immune system is in your gut, so when healthy, we tend to be able to fight off infections faster and better, says Yufang Lin, MD., at the Cleveland Clinic for Integrative Medicine. Choosing whole, unprocessed foods does wonders for overall health. The focus should be on incorporating a variety of whole foods, fruits, vegetables, and water in your daily diet.

Several whole plant foods contain antioxidants, fiber, and vitamin C, all of which may lower your susceptibility to illness. Healthy fats like olive oil and omega-3s are highly anti-inflammatory. These food choices can help boost your immune system and combat illnesses. Another immunity booster selection is garlic. One-half of a clove is beneficial. Chop it in foods or roast it whatever is palatable for you. Also, Vitamin C-rich foods are beneficial.

Many people drink orange juice, but most brands have a lot of sugar, so it becomes counter-productive. It is best to get vitamin C from oranges, broccoli, or cantaloupe. Eating foods rich in antioxidants, such as colorful fruits and vegetables, including berries, carrots and spinach, will help build a strong immune system. Gut health and immunity are deeply connected. A healthy gut will support a healthy immune system and vice-versa.

We tend to be more mindful of water consumption during the warmer months, but we must also remember to stay hydrated during the colder months. You should be drinking at least half your bodyweight in ounces of water daily. Hydration does not necessarily protect you from germs and colds, but preventing dehydration is important to your overall health. Dehydration can increase your chances of becoming ill.

To prevent dehydration, you need to drink enough water daily, so that your urine is clear and odorless. A fluid in your circulatory system called lymph is largely made up of water and carries infection-fighting immune cells throughout your body. Being dehydrated slows down the movement of the lymph, which can lead to a weaker immune system.

Your immune system, when strong, does a remarkable job of defending against disease-causing microorganisms. Sometimes it fails, so when a germ penetrates your immune system, it can make you ill. It is possible to boost your immune system to prevent this from happening as discussed. If you do get ill, it is your body telling you to take some time off to rest and recharge, and to avoid getting others sick.

The benefits of a healthy lifestyle, by choosing healthy habits, will not only strengthen your immune system but will also have positive effects on the other systems of your body, leaving you feeling healthier and more energized for your life!

Also, continue to wear a mask, practice social distancing, and wash your hands often. Be Safe and Be Well!

The content shared from HOW (Heart of Wellness) is for informational purposes only and is not intended nor should it be used to diagnose or treat any medical condition. Consult with your doctor if any questions. HOW is a nonprofit based in Centerville, MA and Boca Raton, FL. that specializes in mindful wellness and self-care programs along with professional development for schools, business, and communities. We want to hear from you, whether it is about this article, COVID-19, or anything else health-related. Send questions and comments to: info@heartofwellness.us

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HEART OF WELLNESS Immune-strong movement and nutrition - Barnstable Patriot

Luke Coutinho Holistic Healing Systems, a company that focuses on integrative and preventive medicine, disease and coaching has recently joined forces with conscious lifestyle store Saukhyam by adopting the shop-in-shop concept in to their business model. With its retail presence in Goa, Saukhyam has established a holistic and wellness product line that connects farmers and vendors across the country. The collaboration aims to showcase a part of Lukes Wellness Market within the store. With Saukhyams vision of creating a sustainable food chain being in line with Luke Wellness Markets approach, the tie-up aims to strengthen the brands coveted retail presence in the micro markets of Goa as well as across the country.

This launch comes close on the heels of success achieved by Lukes Wellness Market that is committed to sourcing products and connects farmers and vendors across the country doing ethical work in the food and lifestyle space. This is the first timeever that the brand is working with a lifestyle and wellness retailer in this capacity to have a concurrent retail presence in multiple markets.The brand has put up a Lukes Wellness Market section within the store that will be revised on a monthly basis. The section displays a variety of hand selected and handpicked products by the holistic mastermind himself. The brand has also infused products ranging from lifestyle categories like food, nutrition, utensils, skin care, cosmetics, books, clothing and fitness accessories, to lend a more holistic appeal.

The shop-in-shop model will enable buyers to touch and feel the product before buying. This initiative is aimed at translating Lukes Wellness Markets holistic approach into a tangible experience. With this strategic move, the brand aims to strengthen its multi-country presence through such models and is looking at scaling the business across various food, wellness and lifestyle stores in the country.

Speaking about the association, Luke Coutinho, Holistic Lifestyle Coach-Integrative Medicine says, Through this launch we are very passionate about bringing an unparalleled level of trust, integrity and expertise to our clients, patients and followers. With this tie up, we aim to expand and create an ethical food chain with complete transparency to support the farmers and local vendors sourcing quality and authentic health products. This collaboration allows us to provide wellness in an engaging way, enabling to touch new markets and shoppers in the process.

About Luke Coutinho Holistic Healing Systems Pvt. Ltd.Luke Coutinho Holistic Healing Systems Pvt. Ltd. focuses on integrative and preventive medicine, disease and coaching with its team of medical doctors, nutritionists, registered dietitians, yoga therapists, lifestyle coaches, clinical dietitians, emotional and mental health professionals and integrative medicine specialists practicing across the globe. The Company has its main presence across India, Dubai, Middle East, Africa, the U.K., and the U.S. The companys ecosystem includes building sustainable and healthy food chains across India.

About Lukes Wellness Market:

Lukes wellness market is an extension of Lukes holistic health store that was launched with the objective of supporting the fair-trade farmers, sustainable and holistic living, and improving the food chain. Live markets are organized across cities wherein farmers and vendors bring in fresh, chemical-free produce and other lifestyle goods grown the ethical way. People across all age groups come together, shop, eat, indulge in fun activities, interact, build communities and make it a family event. It is a step towards resetting the existing food chain in our country and worldwide by making it an honest and ethical one. Lukes wellness market enables consumers to interact and meet the farmers to understand where their food actually comes from.

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Luke Coutinho Holistic Healing Systems adopts the shop-in-shop model to revolutionize its retail presence - - Goa Chronicle

Global Alternative Healthcare Providers Market: Overview

Practice of complementary and alternative medicine comprises many different areas of medicines. In addition to that, it is possible that many parts of one field will overlap with another in another area. A case in point is acupuncture, which finds use in both alternative and conventional medicine. Alternative medicine refers to those medical treatments that find utilization instead of conventional therapies. Few people call them complimentary or integrative medicine. Many people make use of alternative therapies so as to make them deal and feel better with diseases like cancer. In this type of treatment, how one feels is an important part in how you cope up with the disease.

Many of the alternative healthcare therapies focus on the reduction of and relaxation from stress. These therapies increase general sense of wellbeing, relieve anxiety, and calm ones emotions. Several doctors, researchers, and nurses have exhibited interest in the concept of positive emotions making improvements in ones health. These factors are estimated to propel the global alternative healthcare providers market toward growth over the forecast tenure.

This report on the global alternative healthcare providers market takes a closer look at the key changes in consumer preferences and those preferences affect the growth of market. The insights offered into the report assist investors and the market players in making an informed choice about the market. The information shared in the report will help the stakeholders formulate strategies accordingly

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Global Alternative Healthcare Providers Market: Trends and Opportunities

Growing Faith and Awareness in Alternative Medicines Escalates Demand

The global alternative healthcare providers market has prospered on the back of the growing interest of people in such forms of medicines. Growing preference for alternative medicines has resulted from peoples increasing willingness to experiment with alternative medicines.

Alternative healthcare providers make an offering of a wide variety of products and practices and medical and healthcare systems that are used by patients sans medical supervision. Usually, alternative medicines and treatments are not availed by the people suffering from various chronic diseases like diabetes, cancer, liver disease, and osteoporosis. However, there has been a slight change in attitude, a few patients suffering from such chronic diseases are opting for alternative medicines. Such changes in the behavior pattern of patients are expected to spearhead the expansion of the global alternative healthcare providers market in years to come.

Yoga, ayurveda, homeopathic medicines, acupuncture, and unani medicines are some of the types of alternative medicines. The global alternative healthcare providers market is likely to be driven by growing adoption and use of various natural wellness and supplements medicine. In addition to that favorable government initiatives in certain countries, particularly in the Asia Pacific, are expected to create substantial opportunities of growth for the global alternative healthcare providers market over the period of review.

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The report includes an elaborate executive summary, along with a snapshot of the growth behavior of various segments included in the scope of the study. Furthermore, the report sheds light on the changing competitive dynamics in the global Alternative Healthcare Providers market. These indices serve as valuable tools for existing market players as well as for entities interested in entering the global Alternative Healthcare Providers market.

Global Alternative Healthcare Providers Market: Competitive Landscape

Key players profiled in the global alternative healthcare providers market are The Healing Company, Columbia Nutritional Inc., Pure encapsulations, Inc., John Schumachers Unity Woods Yoga Center, Pure encapsulations, Inc., and Allen Laboratories Ltd.

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Global Alternative Healthcare Providers Market Analysis Size, Share, Trend, Current Demand, and Business Opportunities - Murphy's Hockey Law

Thousands of bears, locked in rows of rusty cages so small that they can barely move, stare out through the bars as their bile is drained into containers. Their captors intentionally drill holes into the bears gallbladders to collect their bile for a Traditional Chinese Medicine (TCM) known as Tan Re Qing. These bears spend their entire lives, which often last for over 30 years, inside bile farms, which animal activists dub houses of horror. Animals Asia estimates that more than 12,000 bears are currently held in facilities like these in China, South Korea, and Vietnam.

In March, Chinas National Health Commission (NHC) began recommending Tan Re Qing to treat COVID-19 symptoms. Credible evidence that bear bile helps to treat COVID-19 symptoms does not exist, and according to Clifford Steer, a professor of genetics and medicine at the University of Minnesota, the Tan Re Qing treatment may even worsen patients conditions by decreasing their immune responses. Another inclusion on the NHCs list of TCM treatments for COVID-19 is a pill called Angong Niuhuang Wan, which contains illegally trafficked rhino horn and also has not been proven effective.

As another response to the pandemic, Chinas National Peoples Congress announced in February measures that ban wet market vendors from selling wildlife, including so-called bushmeat, for direct human consumption. However, the captive breeding of wild animals for use in TCM, and the sale of the resulting products (along with sales of exotic furs and leathers), remains completely legal. Breeding of captive wildlife is and remains widespread in China, despite the recent ban on wildlife sales at wet markets.

The NHCs Tan Re Qing recommendation shines a light on Chinas explicit support for the captive wildlife industry to produce animal-based TCM. Conservationists oppose the captive wildlife industry because raising generations of animals in captivity, in addition to sanctioning cruelty, does nothing to ensure the species survival in the wildborn-and-bred captive animals can never be safely released. China policymakers largely ignore the cruel conditions that captive animals endure and falsely claim that breeding animals in captivity reduces their extinction rates. The bear bile in Tan Re Qing is only the most prominent example of a wildlife-based TCM remedy that is sourced from generations of captive animals. Chinese law also permits the captive breeding of pangolins, tigers, musk deer, peacocks, cats, dogs, and rhinos.

Conservation leaders in China are continuously imploring policymakers to crack down on the captive breeding of wildlife, for TCM remedies and all other uses; captive breeding is indisputably driving the illegal poaching and trading of wild animals. The legal existence of the captive breeding industry makes it easier to pass off poached animal products for ones that have been legally harvested. A 2012 investigation by the Environmental Investigation Agency (EIA), a conservation nonprofit organization, in China uncovered a common method among poachersinvolving the reuse and counterfeiting of legally-issued government permitsthat enables the trafficking of illegal animal products. The commercial sale of tiger parts, for example, is illegal in China, yet tiger breeding and the distribution of their skins and other body parts are exempt from prosecution if the parts are obtained under forestry administration permits, purportedly for educational purposes. This loophole, exploited since the mid-1980s, allows tigers to be continually trafficked into tiger farms, where they are forcibly bred and their parts harvested for profit. In a 2017 investigation, the EIA observed how tiger farms are thinly disguised as conservation-driven amusement parks; a few tigers in these parks perform for tourists while thousands are caged behind the scenes. Up to 6,000 tigers are currently held captive throughout China, while globally fewer than 4,000 tigers remain in the wildrepresenting a 96 percent population decrease since the start of the 20th century.

The TCM industry uses, usually ineffectively, many species of both trafficked and captive wildlife. Tigers genitals are used as an aphrodisiac, their teeth to treat fevers, and their brains to treat laziness; rhino horns are used as a treatment for fevers and convulsions; shark fins are used to help fight cancer and increase fertility. None of these remedies have been proven medically effective. According to TIME, the false idea that TCM ascribes extraordinary health benefits to rare animal parts has become a persistent misconception that is difficult to eradicate. Scientific evidence notwithstanding, TCM products derived from illegally-trafficked wild animals are perceived by some consumers as being more potent than those sourced from captive animals. Aron White, wildlife campaigner for the EIA, confirms that some TCM enthusiasts consider only products containing wild-raised animals to be the real deal.

In recent years, TCMs overall popularity has grown internationally and offerings from its various sects can now be found in more than 180 countries. Under the guise of TCM, wildlife traffickers are plucking many already vulnerable species from their habitats and leading them closer to extinction. The United Nations Office on Drugs and Crime identifies TCMs global growth as a primary cause of the recent large spike in wildlife trafficking. The TCM industry currently exploits 36 vulnerable speciesmany of which are not protected by the Convention on International Trade in Endangered Species of Wild Fauna and Florain various ways for their purported medicinal uses. The rising popularity of TCM is driving a proportional increase in demand for wildlife-based remedies.

Dr. Lixing Lao, President of the Virginia University of Integrative Medicine, and practitioners of reputable TCM state that wildlife traders do not necessarily believe in the supposed healing effects of wildlife-based TCM products; they simply exploit the TCM industrys popularity and push misinformation for their own profit. While the conservation community decries wildlife-derived TCM for its role in generating demand for endangered species, the medical community emphasizes these animal-based treatments lack of proven efficacies. Multiple Chinese nonprofit organizations recently proposed that the International Union for the Conservation of Nature assist with ending Chinese companies legal use of endangered species in TCM. Many TCM enthusiasts, both in China and worldwide, openly condemn wildlife-based remedies, which they feel tarnish the practices reputation. Some TCM practitioners, including Dr. Lao, believe that the wildlife industryboth legal and illegalhas infiltrated the TCM industry, thus exploiting and damaging the venerable traditions global image.

The ready availability of wildlife-based TCM is leading to an increase in misinformation regarding both its historic use in Chinese culture and its effectiveness. According to Dr. Lao, teachings dating back to the Tang dynasty state that TCM treatments should be derived solely from plants, not animals. Modern-day TCM practitioners continue to contradict these teachings by exploiting trafficked and captive wildlife for supposedly medicinal uses. Although the majority of TCM distributors have removed wild animal parts from their pharmacopeia in recent years, many vendors doing business in Asian countries and even online persist in selling remedies derived from animals.

Wildlife-based TCM may be in the minority of TCM remedies, but the NHCs recommendation of Tan Re Qing to treat COVID-19 is especially angering to animal activists, given that COVID-19 is a zoonotic disease. Zoonotic diseases are a classification of infectious scourges driven by exploiting animals and their habitats. The ongoing use of ineffective wildlife-based TCM treatments for a virus that was likely unleashed by wildlife exploitation and has escalated into a pandemic, aside from being deeply ironic, puts many human lives at risk while greatly exacerbating the mass species extinction event already underway. Strengthening the scientific link between the current pandemic and wildlife-based TCM, a 2020 microbiology study published by Chinese and German researchers deduces that the Rhinolophus ferrumequinum bat species used in some TCM treatments may be the very one that originally hosted the novel coronavirus before it crossed the species barrier. A TCM formula called Ye Ming Sha is sourced from these bats feces to treat eye conditions, while their dried body parts are consumed as a supposed detox remedy. Despite Chinas ban on the sale of live wild animals (including bats) at food markets, the loophole that allows the trading and handling of bats for TCM poses a serious risk for future zoonotic disease outbreaks.

The inclusion of Tan Re Qing in the NHCs medical compendium also raises questions about the agencys possible motive behind the poorly-timed endorsement. The Chinese government has a history of enforcing government policies that openly favor corporate profits over conservation. Chinas so-called Wildlife Protection Law, enacted in 1989, is a misnomer, as it classifies wild animals as a resource to be used for human benefit. Serving to further legitimize the commercial use of wildlife, the law was amended in 2016 to explicitly assert that animals can be used for TCM remedies. The China Wildlife Conservation Association (CWCA), a nongovernmental organization operating under the framework of the China Science Association that is tasked with implementing conservation laws and policies, misleadingly promotes wildlife farming and captive breeding as animal protection under Chinas Wildlife Protection Law. The CWCA instituted the laws protection for human use clause, which declares that the state encourages breeding and farming of wildlife animals, thereby firmly establishing animals as a resource for human utilization. The willingness of the CWCA to promote wildlife productseven during a wildlife-linked viral pandemicis perhaps less surprising, given that several CWCA board members are executives of TCM companies that sell animal-based remedies. The continuation of Chinas policies that value profits over conservation further jeopardize the survival of endangered wildlife.

The World Health Organization (WHO) joins Chinese policymakers in refusing to unambiguously condemn wildlife-based TCM, despite its risks to global public health. The WHOs global medical compendium includes TCM but fails to specifically condemn the modalitys use of wild animal parts. Panthera, a global nonprofit organization dedicated to wild cat conservation, in 2019 released a statement expressing concern that the WHOs equivocation regarding TCM will be perceived by the global community as a stamp of approval from the United Nations on the overall practice [of TCM], which includes the use of remedies utilizing wild animal parts. The WHO has since stated that it does not condone the use of wildlife in TCM, but has not specifically excluded wildlife-based TCM from its medical compendium. Key conservation players including the EIA and the Wildlife Conservation Trust join Panthera in expressing fears that wildlife poaching and trafficking syndicates will interpret the WHOs ambiguity in their own favor. WHOs failure to unequivocally condemn wildlife-based TCM only makes it easier for wildlife profiteers to traffick animal parts under the guise of sanctioned medical usage.

While Chinas traditional herb-based medicines are popularizing TCM worldwide, wildlife traffickers are simultaneously exploiting the ancient systems popularity to expand their own market. Wildlife-derived TCM modalities should be vilified by all for their role in harming animals. Whether an animal-derived product is sourced from trafficking or captivity, the ecological impacts are similarly destructive. Though the sale of exotic wildlife in Chinese wet markets is now banned, the wildlife industry, both legal and otherwise, continues to exploit animals through the development and promotion of ineffective treatments for a wide range of medical conditions, including COVID-19 itself. In order to help with slowing the extinction rates of vulnerable wildlife, consumers everywhere must ostracize the wildlife industry and its hijacking of Traditional Chinese Medicine, and policymakers worldwide must explicitly condemn its morbid use of animal parts.

Read More

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In China, Traditional Remedies for COVID-19 Are Fueling the Wildlife Trade - Sentient Media

CLEVELAND, Ohio Northeast Ohio natives JoAnn and Bob Glick have pledged $42 million to MetroHealth System, the largest gift in the hospital systems 183-year history.

The couple chose MetroHealth to receive the gift because of the hospital systems commitment to community health and its goal of reducing health disparities, passions that the Glicks share. The gift was announced today.

The gift enables MetroHealth to address social determinants of health so that everyone has equal access to health care and preventative medicine, especially underserved women and children.

We hope that zip codes dont matter anymore, said JoAnn Glick, who trained as a registered nurse with an emphasis on community health.

In recognition of the gift, MetroHealths new main hospital, now under construction on West 25th Street, will be named the MetroHealth Glick Center. The 11-floor hospital is part of the health systems $946 million campus transformation project, which is designed to spur development in the surrounding neighborhood.

However, the $42 million gift will not be used for hospital construction.

It will be wonderful to have our name on the building, said Bob Glick, founder and former CEO of Dots womens fashion company. But whats really important is what happens inside and throughout the neighborhood.

Clearly, the amount of money is huge and will help us focus on our efforts to ensure Cleveland is a healthier place, MetroHealth president and CEO Dr. Akram Boutros said. Beyond that, the due diligence and inquisitiveness that Bob and JoAnn showed is a huge boost in the arm. It gives us confidence that what we do resonates with individuals who want to see change.

The Glicks want to see their gift used to improve the lives of Clevelanders, Boutros said.

They are so committed to making a difference to folks who dont have access to health care and the interventions needed to live their best lives, Boutros said.

The pledge will be split into two funds:

Choosing MetroHealth

A 2013 Plain Dealer profile that described how Boutros was changing the hospital systems culture as the new CEO caught the couples interest and introduced them to MetroHealths mission.

They were intrigued that Boutros wanted to emphasize keeping people healthy rather than simply treating illness. As they weighed options for philanthropy and researched the hospital system, they were impressed by the passion, caring and engagement of everyone from the maintenance staff to physicians.

They wake up every day wanting to serve the people of Cleveland, Bob Glick said. There is a culture of over-the-top passion for their patients thats hard to describe. That made a difference to us.

This isnt the first substantial gift that the Glicks have given to the hospital system. In 2019, the couple gave $500,000 for programs that help children overcome trauma through the arts, and evaluate children for autism spectrum disorders.

They began The JoAnn and Robert Glick Family Fund of the Cleveland Foundation in 2007.

The Glicks have deep roots in Northeast Ohio. Bob was born in Shaker Heights and earned degrees from Ohio University and the University of Michigan.

In 2011, after 36 years as founder, CEO and chairman of Dots, Bob Glick sold the company to a private equity firm. Dots operated more than 400 stores in 28 states, including Ohio. All stores were closed in 2019.

JoAnn Glick grew up in Youngstown and received a nursing degree from the University of Michigans School of Nursing. She moved to Cleveland in 1976 to attend nursing school and work at University Hospitals.

Bob Glick hopes that the couples gift will inspire wealthy Clevelanders to consider giving to the citys nonprofits. For their part, the couple plans to continue backing MetroHealth.

This is not a one-time gift, Bob Glick said. We want to keep coming back and supporting Metro.

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JoAnn and Bob Glick donating $42 million to MetroHealth System, largest gift in its history, to help underser - cleveland.com

Paris-based Ipsen secured Fast Track designation from the U.S. Food and Drug Administration (FDA) for Onivyde (irinotecan liposome injection) for study patients with small cell lung cancer (SCLC) who progressed following a first-line platinum-based regimen. Onivyde, in combination with fluorouracil and leucovorin, was previously approved for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy.

The designation marks the second Onivyde secured in the past six months. In June, the FDA awarded the designation to Onivyde for patients with previously untreated, unresectable, locally advanced and metastatic pancreatic ductal adenocarcinoma.

Ipsen is conducting an ongoing Phase III study assessing Onivyde as a monotherapy for SCLC study patients who have progressed on or after a first-line platinum-based regimen.

Howard Mayer, Ipsens head of research and development, called the Fast Track designation for Onivyde an extension of Ipsens focus and contribution to the oncology landscape.

With this aggressive and often late-stage diagnosed form of lung cancer, we are proud to be one step closer to making another treatment option available to patients, Mayer said in a statement.

Lung cancer is the second most common cancer in the United States. In 2020, the American Cancer Society estimates there to be about 228,280 new cases of lung cancer in the country.SCLC comprises 10% to 15% of all lung cancers and is a very aggressive form of cancer with about 70% of people having metastatic disease when they are diagnosed.

Elsewhere around the globe:

RevoluGen U.K.-based RevoluGen announced new results from its improved Fire Monkey/Fire Flower version 8 (FMv8) protocol. Results show the protocol demonstrated a 30Gb+ yield of long DNA reads raw data of anE. Colibacterial sample on a single Oxford Nanopore Technologies (ONT) MinION flow cell. The increased yield offers significant potential cost and performance advantages across all sequencing platforms, the company said. The FMv8 protocol introduces a needle-aspirate-based, cell-resuspension step prior to cell lysis that boosts DNA recovery. The spin-column has been optimized to deliver homogenous High Molecular Weight DNA extracted and purified from bacterial and mammalian samples. ForE. Coli, the FMv8 protocol allows the ONT MinION to deliver optimal sequencing throughput at an impressive N50 of 36.7Kb, the company added.

GENFIT Frances GENFIT announced the conclusion of the partial buyback of GENFITs 6,081,081 convertible bonds maturing in October 2022. The company said it achieved satisfactory results. Once the buyback is complete, the company will announce the final results.

Abivax Also based in France, Abivax completed recruitment for its Phase IIb induction study for ABX464 as a treatment of patients with moderate-to-severe ulcerative colitis. Top-line results of the PhaseIIbUC induction study are expected to be available in Q2 2021. The Phase IIb induction study in patients with moderate-to-severe UC, enrolled the first patient in August 2019. In addition, Abivax initiated a companion long-term open-label maintenance study in which patients who have completed the induction study were eligible to continue the treatment to further investigate the long-term safety and efficacy profile of ABX464. Previously, the company announced positive results of the previous Phase IIa induction study in UC in September 2018.

HZI Germanys Helmholtz Centre for Infection Research (HZI) secured two awards worth up to $15 million from CARB-X to develop non-traditional approaches against antibiotic-resistant pathogens. The goal is to develop a first-in-class treatment for Staphylococcusaureusinfections and thereby prevent exacerbation of pneumonia. The drug is a small-molecule inhibitor of theS. aureus-hemolysin,a virulence factor responsible for thebacteriums pathogenicity and ability to cause infection and disease. The drug would disarm the pathogens most importanttoxin that causes damage to lung tissue and immune cells. Additionally, HZI is looking to develop a new treatment for difficult-to-treatPseudomonas aeruginosainfections in cystic fibrosis patients. The new pathoblocker treatment aims to disarm pathogens and suppress the disease-causing properties ofP. aeruginosabacteria, instead of killing the bacteria as an antibiotic would aim to do.By rendering the pathogens harmless instead of killing them, selection pressure on the pathogens is relieved and resistance is likely to develop more slowly.

ERS Genomics Irelands ERS Genomics Limited, and Germanys Vivlion GmbH, announced a non-exclusive license agreement granting Vivlionaccess to ERS Genomics CRISPR/Cas9 patent portfolio, to enhance Vivlions gene editing reagents and screening services. Vivlion holds an exclusive license to Goethe University of Frankfurts proprietary 3Cs technology for the production of next generation 3Cs CRISPR/Cas gRNA libraries. The license from ERS Genomics now enables Vivlion to offer both R&D reagents and screening services to its customers worldwide. Financial details of the agreement were not disclosed.

Noema Pharma Swiss startup Noema Pharma secured $59 million in a Series A funding round, as well as four neurological product candidates from Roche. The product candidates will be developed in neurological indications with severe unmet need, such as seizures in tuberous sclerosis complex (TSC), trigeminal neuralgia, Tourette syndrome and other rare neurological disorders.

TSK Laboratory Netherlands-based TSK developed a new needle that could save 4% to 8% of vaccine doses, which could prevent wasted parts of the COVID-19 preventative medicines. A conventional needle has an average dead space of 45 microliters, which is the amount of vaccine or medicine being wasted per injection. TSK Laboratory developed an inventive and patented needle in 2014 in which this average dead space is reduced to 14 microliters. TSK said its Low Dead Space technology prevents waste of liquid vaccine when it is being extracted from the container, which will ultimately stretch the number of available doses.

Horizon Discovery Group U.K.-based Horizon Discovery Group granted a license to Chinas Sanyou Biopharmaceuticals Co. for its cGMP-compliant CHOSOURCE platform. Sanyou will use Horizons gene-edited Glutamine Synthetase (GS) knockoutChinese Hamster Ovary(CHO) K1 cell line for the developmentof pre-clinical antibody drug projects andto support the clinical development and commercialization of its customers human biotherapeutic products as well as offering the platform through its contract research services.

eTheRNA Belgium-based eTheRNA immunotherapies NV entered into a strategic agreement with China Grand Pharmaceutical & Healthcare Holdings Ltd. to establish a new joint venture company, Nanjing AuroRNA Biotech Co., Ltd. in Mainland China. The new company will deploy eTheRNAs proprietary mRNA technology for pharmaceutical research and development and production in the Greater China Region. This follows an undisclosed equity investment by China Grand Pharma in eTheRNAs Series B financing round earlier in 2020. The formation of AuroRNA Biotech with China Grand Pharma provides eTheRNA access to the Greater China market for selected mRNA cancer and infectious disease vaccine programs, its proprietary mRNA formulation technologies and GMP manufacturing process technology. eTheRNAs global programs will benefit from China Grand Pharmas development, clinical and marketing input.

4D Biomaterials Innovate UK awarded 4D Biomaterials, a spinout by University of Birmingham Enterprise and Warwick Innovations, to develop new commercialization of a new class of liquid resins that can be custom-printed into bioresorbable 3D tissue scaffolds providing accelerated and improved wound healing following major surgery.

Tubulis Germanys Tubulis formed a strategic collaboration with WuXi STA and WuXi Biologics to manufacture and advance Tubulis next generation antibody-drug conjugates (ADCs) towards IND-enabling studies. Tubulis has developed a dual platform approach to generate uniquely matched and disease-specific ADCs that combine selective antibodies with effective payloads. Tubulisrecently completed a 10.7 million Series A to expand the therapeutic potential of ADCs and to advance itsuniquely versatile and customizable ADC technology portfolio. The company utilizes two proprietary technologies to tacklelimitations of currently approved ADCs, which includestability and payload-driven toxicity.

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Many people experience smelly armpits from time to time. When people sweat, the liquid mixes with the bacteria on the skin. When this dries, it can cause an unpleasant smell.

Several remedies are available for excessive sweating, including over-the-counter treatments, prescription medications, injections, and more.

In this article, we look at what causes smelly armpits, how to treat them, and when it might be a good idea to speak with a doctor.

Sweat is responsible for smelly armpits. Sweating is a normal and necessary bodily function that stops people from overheating.

There are 24 million sweat glands on the body. Most of these are eccrine sweat glands, and the others are apocrine sweat glands. People have lots of both types of sweat gland in the armpits.

When a person exercises or becomes too hot, the sweat glands release sweat, which evaporates and cools the body down. Stress and intense emotions can also make people sweat.

Eccrine glands release a clear liquid that does not smell. However, if it dries on the skin, it can smell.

Apocrine glands release a thick fluid that smells when it mixes with the bacteria on the skin.

The sweat glands become more active in both males and females during puberty. As a result, it is common for teenagers to start to get smelly armpits when they did not before.

Some people have a medical disorder that makes them sweat more than they should. The name for this condition is hyperhidrosis.

Hyperhidrosis affects about 3% of the population. People who have the disorder have overactive sweat glands that release sweat even when they are not hot or exercising.

Hyperhidrosis is usually harmless, but it is sometimes the result of an overactive thyroid.

When sweat mixes with bacteria, it can lead to a distinctive body odor, which people commonly refer to as B.O. If this odor becomes chronic, doctors call it bromhidrosis.

Some foods, such as garlic, can change the way sweat smells.

Good hygiene can help prevent smelly armpits by getting rid of the bacteria that cause the odor.

People should shower or bathe once a day and after exercise. They should also wear clean clothes every day and change their clothes after exercising.

As well as practicing good hygiene, people can try other ways to combat smelly armpits. These include:

Shaving the armpits and using a deodorant or antiperspirant can often help prevent body odor. Regular deodorant comes with a fragrance that will help mask the smell.

Antiperspirant contains chemicals that stop people from sweating. They plug the sweat glands, which tells the body to stop making sweat.

These simple measures might not work for people with hyperhidrosis.

If sweating is excessive, it can cause smelly armpits even if a person washes regularly and uses deodorant or antiperspirant.

The first thing that a doctor will recommend is usually a prescription strength antiperspirant. Sometimes, these might burn or irritate the skin. If this happens, the person should tell their doctor.

If prescription strength antiperspirants do not stop the excessive sweating, doctors might suggest the treatments below.

People usually refer to botulinum toxin injections as Botox.

Sometimes, doctors inject tiny amounts of Botox into the armpits to treat excessive sweating.

Botox injections help stop excessive sweating by blocking a chemical in the body that stimulates the sweat glands.

For most people, it takes 45 days to work, and the effects usually last for about 46 months.

Some people might find the injections painful.

If excessive sweating affects the whole body, doctors might suggest using anticholinergic medicines.

Anticholinergic medicines stop people from sweating, so they are not generally suitable for athletes or people who live in hot climates.

Common side effects of these drugs include:

Eating some foods, including garlic and onion, can make sweat smell different. Alcohol can also have this effect. Consuming certain foods and drinks may, therefore, lead to a sudden change in body odor around the armpits.

Stress and anxiety can make people sweat more than usual. Sometimes, this can lead to a sudden change in the way the armpits smell.

Many different factors can cause what doctors call secondary hyperhidrosis. This term means that the excessive sweating is a symptom of something else.

Possible causes of secondary hyperhidrosis include:

Excessive sweating is not necessarily the cause of all sudden changes in armpit odor.

For instance, the skin condition intertrigo might cause a musty smell. This condition, which causes a rash, develops in folds of the skin, such as those in the belly, under the breasts, and in the armpits.

Doctors might recommend using a special soap that contains 1% ketoconazole. They will also suggest keeping the affected area as clean and dry as possible.

Everyone will have smelly armpits from time to time. It is perfectly normal and not typically a cause for concern.

If smelly armpits are a more frequent occurrence, though, they can get in the way of everyday life.

Both hyperhidrosis and bromhidrosis can cause distress and social problems. When this is the case, the person should speak to a doctor.

The best way to prevent smelly armpits is to wash daily and after sweating.

Using antiperspirant or deodorant and shaving the armpits can also help.

Avoiding alcohol and certain foods, such as onions and garlic, will also help prevent smelly armpits in some cases.

Sweating is an essential bodily function and is perfectly normal. When the liquid dries, it can smell. Most people will have smelly armpits at times.

Washing daily and after exercising, wearing clean clothes every day, and using antiperspirant or deodorant should usually prevent the problem.

Some people have a condition that makes them sweat too much. Doctors call this hyperhidrosis, and it can sometimes lead to body odor.

Various factors can cause a sudden change in armpit odor. These include certain foods and medications.

Anyone who finds that smelly armpits are affecting their quality of life should speak with a doctor.

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Smelly armpits: Causes, treatment, prevention, and when to seek help - Medical News Today

Originally published in Chinese by Shanghai Jiao Tong University Press, Elsevier secured the rights to publish this important reference book in English at a time when knowledge sharing on preventing the spread of and treating patients infected with the novel coronavirus, subsequently named SARS-CoV-2, was at its most critical.

The three Co-Editors-in-Chief, Jie-Ming QU, Bin CAO and Rong-Chang CHEN, are senior physicians, as well as clinical and scientific research experts specializing in pulmonary diseases and critical care medicine with relevant experience in Wuhan, China, where the outbreak was first identified in December 2019.

Along with other physicians working in China, the Co-Editors-in-Chief have built up deep knowledge and insights on the prevention, control, diagnosis and treatment of the disease, all of which are now globally relevant to managing the COVID-19 pandemic.

COVID-19: The Essentials of Prevention and Treatmentelaborates on the ethology, pathogenesis epidemiology, clinical characteristics, treatment principles, rehabilitation and prevention, as well as prevention and control measures for COVID-19 to provide healthcare workers first-hand information on the prevention, control, diagnosis and treatment of COVID-19.

Key features of the book include:

Quotes

Nanshan ZHONG, Peer Reviewer Academician of Chinese Academy of Engineering Director of National Clinical Research Center for Respiratory Disease (The First Affiliated Hospital of Guangzhou Medical University)

"We've entered a normalization phase in the prevention and control of COVID-19, and I believe the insights contained in this book on emergent diseases especially those on acute respiratory infections that have significant socio-economic impact are extremely informative and highly valuable in the prevention and control of future outbreaks. COVID-19: The Essentials of Prevention and Treatmentis the English version of Elsevier's first Chinese-authored publication on the topic of the novel coronavirus. I sincerely hope this book can facilitate better and effective prevention and control of the disease through the sharing of knowledge and experience of Chinese healthcare workers."

Chen WANG, Peer ReviewerPresident, Chinese Academy of Medical Sciences and Peking Union Medical CollegeVice President & Academician of Chinese Academy of EngineeringDirector, National Respiratory Clinical Research Center, Leader, National Key Disciplines for Respiratory MedicineVice-Chairperson, Global Alliance Against Chronic Respiratory Diseases

"The English version of COVID-19: The Essentials of Prevention and Treatment is of considerable significance as it provides valuable insights of the experiences of China's healthcare professionals in their combat against COVID-19 in the country where the virus was first identified. As a new and previously unknown virus, the manner in which it mutates and changes means that the virus will manifest itself differently at different time periods, as well as in different geography, demographic and ethnicities. The book offers an important medical reference of the COVID-19 situation at a point in time in China and highlights the interdependency between Chinese and international publishers in facilitating knowledge exchange to address important global issues."

Jie-Ming QU, Co-Editor-in-Chief Professor and Party Chief of Ruijin Hospital Chair of Chinese Thoracic Society

"The essence of this book is founded upon the first-hand account and experience of health care experts working on the front lines in the areas of prevention and control when the novel coronavirus first appeared, which the authors have systematically and meticulously curated to form the framework of the syllabus. This book is an important reference that brings together some of China's finest experts in respiratory and critical care medicine, as well as showcases the country's expertise in clinical research and professionalism in caring for the infirm."

Tiandong QIAN, Chairman of Shanghai Jiao Tong University Press

"The outcome of this collaboration between Elsevier and Shanghai Jiao Tong University Press is significant and its inherent value is of considerable relevance to the international health and science community. We've also signed licensing agreements for Russian, Japanese, Thai, Malaysian and Vietnamese rights to the book, which demonstrates its global impact."

Dr. Glyn Jones, Publisher, Elsevier

"The book proposal from Shanghai Jiao Tong University Press came at a very important time when doctors and nurses in Europe and the US were having to treat patients with coronavirus for the very first time, and were very interested to learn from China's experience, which it had built up in the months before. Recognizing the importance of the book, Elsevier undertook to ensure publication as soon as possible. Elsevier is committed to publishing high-quality content that will be of interest to researchers. So far this year, we have commissioned 17 new books written by researchers from all over the world related to various, different aspects of Covid-19."

Lynn LI, Managing Director Greater China, Elsevier

"Elsevier supports scientific and medical advancement for the benefit of our society. Publishing the English version of COVID-19: The Essentials of Prevention and Treatmentin partnership with Shanghai Jiao Tong University Press is a way for us to facilitate the urgent global effort to understand, contain and eradicate the novel coronavirus. We believe that clear, consistent and evidence-based guidance and resources are crucial to helping communities overcome the pandemic. This book has undergone a rigorous peer-review process and draws on the rich experiences to present a first-hand account of frontline health care professionals combatting the virus over the course of two months."

Elsevier Novel Coronavirus Information Center

Elsevier'sNovel Coronavirus Information Centerprovides expert-curated information for researchers, healthcare professionals and public health officials, including clinical guidance and a portal to access all of Elsevier's COVID-19 research. All resources are freely available. We also have dedicated hubs for healthcare professionals; health educators and students; librarians; and R&D professionals. You can find these in ourCoronavirus Resource Directory.

About Elsevier

As a global leader in information and analytics, Elsevier helps researchers and healthcare professionals advance science and improve health outcomes for the benefit of society. We do this by facilitating insights and critical decision-making for customers across the global research and health ecosystems.

In everything we publish, we uphold the highest standards of quality and integrity. We bring that same rigor to our information analytics solutions for researchers, health professionals, institutions and funders.

Elsevier employs 8,100 people worldwide. We have supported the work of our research and health partners for more than 140 years. Growing from our roots in publishing, we offer knowledge and valuable analytics that help our users make breakthroughs and drive societal progress. Digital solutions such as ScienceDirect, Scopus, SciVal, ClinicalKey and Sherpath support strategic research management, R&D performance, clinical decision support, and health education. Researchers and healthcare professionals rely on our 2,500+ digitized journals, including The Lancet and Cell; our 40,000 eBook titles; and our iconic reference works, such as Gray's Anatomy. With the Elsevier Foundation and our external Inclusion & Diversity Advisory Board, we work in partnership with diverse stakeholders to advance inclusion and diversity in science, research and healthcare in developing countries and around the world.

Elsevier is part of RELX, a global provider of information-based analytics and decision tools for professional and business customers. http://www.elsevier.com

Media contact Jason Chan, DirectorElsevier Communications, APAC+65 6349 02 40 [emailprotected]

SOURCE Elsevier

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Even before the pandemic, more than a third of Americans werent getting the recommended seven plus hours of nightly sleep that industry professionals recommend. Add the stress of everyones new reality, and, by certain estimates, 68% of Americans say they just arent getting enough rest.

While youre probably aware of some of the issues, like mental fog, that can arise when you don't get enough rest, you may not be aware that your snoozing habits may impact all sorts of unexpected thingsthink: how well your heart pumps blood, and even your sex drive.

Most of the systems in our body are predicated on some process of renewal or need for sleep, explains board-certified sleep medicine researcher W. Christopher Winter, MD, the author of The Sleep Solution: Why Your Sleep Is Broken and How to Fix It. Sleep is a fundamental aspect of our thinking, our ability to function, and our immune system. It impacts pretty much everything we need to survive.

So turn off your phone, close the shades, and hop into bed early tonight. If you dont, heres how a lack of sleep may impact your body.

Theres a very strong link between sleep and the immune system in general, says Michael Awad, MD, chief of sleep surgery at Northwestern Medicine and chief medical officer of Peak Sleep. The body repairs just about every cell in the body when it comes to sleep. Sleep deprivation lowers the bodys ability to mount an immune response.

Sleep loss is linked to a higher risk of infection, according to the Centers for Disease Control and Prevention (CDC). One study published in JAMA found that restricting a persons sleep for four hours a night for six days, followed by sleeping 12 hours a night for seven days, can lead to a greater than 50% decrease in the production of antibodies to a flu vaccine. Basically, your body just cant mount the usual immune response when youre wiped out.

Lack of sleep can also lower your immune systems ability to fight tumor cells and lead to the generation of inflammatory cytokines. These proteins are secreted by the immune system and can cause the development of metabolic and cardiovascular disorders.

nadia_bormotovaGetty Images

One study of nearly 117,000 people published in the European Heart Journal found that people who slept less than six hours a night were at a greater risk of developing heart disease than their well-rested counterparts. And getting irregular sleepthat is, having no consistent bedtime and wake timecan raise your risk of having some kind of cardiovascular event, including stroke, congestive heart failure, and coronary heart disease, according to a study published in the Journal of the American College of Cardiology.

There are a tremendous number of mechanisms at play here, Dr. Winter says. When you are sleep deprived or have fragmented sleep, your blood vessels lose, to some extent, the ability to expand and contract to regulate things, he says. People also tend to be at a higher risk of developing high blood pressure when they dont get enough sleep, Winter says, which can be tough on your heart.

Sleep deprivation can also increase cholesterol levels and general inflammation throughout your body, leading to the formation of plaque in the blood vessels, Dr. Awad says. When blood vessels start to form plaque, the heart has to work harder, he explains.

There are a lot of reasons for this, Dr. Winter says. When youre fatigued, your brain prioritizes getting sleep over other things, he says. But Dr. Winters says other chemicals that are important for sexual performance and arousal, such as oxytocin, can be lowered by sleep deprivation.

One study in JAMA restricted 10 men's sleep for a week and found that the levels of the sex hormone testosterone in their bodies decreased by up to 15%. (Testosterone is a hormone that can fuel a person's sex drive.) The reverse is also true: Another study published in JAMA found that people who got more sleep than usual were more likely to have sex the next day. Meaning, if you hit the hay earlier, you just might be up for a little something extra.

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There are a few reasons for this. One is that people tend to make bad eating decisions when theyre tired, Dr. Winter says. People are also typically more sedentary and less likely to work out when theyre tired, which also can lead to weight gain, he says.

Research published in the journal Sleep found that people with restricted sleep had altered levels of endocannabinoids, one of the chemical signals that affect appetite, and the brains reward system. The researchers also discovered that when people were sleep-deprived, they ate more and unhealthier snacks between meals, at the same time that endocannabinoid levels were at their highest.

Older research has also found that women who get less sleep tend to weigh more than their better-rested counterparts, likely for the reasons above, Dr. Winter says.

Theres a direct correlation between lack of sleep and diabetes, Dr. Awad says. Its due to your bodys ability to regulate insulin, a hormone produced in the pancreas that controls your blood sugar, he says. Lack of sleep reduces the production of insulin from the pancreas and decreases gluten tolerance, Dr. Awad says. Cells are then less effective at using insulin, and that can lead to the development of diabetes.

To be clear: Sleep deprivation isnt cited by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) as a potential cause of diabetes, but insulin resistancewhich can be caused by lack of sleepis.

How to finally get more shut-eye

If youre struggling with sleep, Dr. Winter recommends first trying to prioritize rest and practicing good sleep hygiene. That includes the following, per the CDC:

If these tried-and-tested tips dont help, Dr. Awad says its a good idea to talk to your doctor about what else you can do to get the rest your body needs.

This content is created and maintained by a third party, and imported onto this page to help users provide their email addresses. You may be able to find more information about this and similar content at piano.io

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5 Things That Happen When You Don't Get Enough Sleep - Prevention.com

Global Preventive Medicine Market: Snapshot

Preventive Medicine is kind of a medical practice that goes by the principle of prevention is better than cure. It includes all the steps taken for preventing the illness and opposes procedure of treatment. Preventive medicine is able to decrease the cases of non-contagious ailments for example, diabetes, tumor, and cardiovascular diseases.

The ongoing examination give an account of global preventive medicine market exhibits a point by point investigation if various parts of the market, for example, limitations, drivers, market figures, and different portions on which the market is relied. This gives a good thought regarding the current and the past market situation to the customers. It is required to settle on their choice further for the market speculation.

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Global Preventive Medicine Market: Trends and Opportunities

The key supporter of the development of global preventive medicine market is rising costs of drugs, recovery medicines, surgeries, and medical gadgets. The pharmaceutical organizations are taking increasingly more interest for preventive drug as they are confronting issues with the customary pharma model, which is neither gainful nor satisfying the demand. Consequently the pharma business has distinguished a sustainable model in preventive medication. This has amazingly contributed towards the market development. Changing attention to individuals alongside expanding reach of eductaion has likewise increased the value of the market development. Be that as it may, the accomplishment of the preventive drug requires an enormous alliance of pharma industry including huge players and new companies with corporate associations and colleges/scholastic organizations, which is uncommon. This is the significant misfortune for preventive drug market. Lack of regional confirmations referring to preventive drug is a huge strategy to shield one from sicknesses may likewise restrain the development. Another factor constraining development is that counteractive action medications capability to confine the healthcare usage has not yet acknowledged on a vast scale in light of the fact that the arrival on venture has never been imparted, keeping individuals enthusiasm for this field under control.

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Global Preventive Medicine Market: Regional Analysis

North America is falling behind different nations to the extent preventive drug market is concerned in view of absence of interest of individuals. As indicated by a journal, Health Affairs, USA will spare just 0.2% of medicinal services payment notwithstanding when 90% of the populace utilize preventive administrations. Hardly any different investigations have likewise shown that preventive measures dont bring down the danger of genuine disease or unexpected passing. European preventive market is developing admirably on account of achievements of the hazard figure the study of disease transmission the locale, which has prompted the authorization of a wide-scope of preventive measures, for example, authoritative arrangements to confine tobacco publicizing and smoking in open spots, wellbeing training for weight, network special occasions for hypertension checking and so on.

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Global Preventive Medicine Market: Competitive LAndscape

The key players operating in the global preventive medicine market include Eli Lilly, Novo Nordisk, Quanterix, Aetna Inc., Cancer Prevention Pharmaceuticals, Inc., Preventive Medical Health Care Co., LTD., American College of Preventive Medicine and U.S. Preventive Medicine., and Phoenix Medicine.

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Preventive Medicine Market : Business Growth, Development Factors, Applications, and Future Prospects - The Haitian-Caribbean News Network

By PTI

NEW DELHI:The Supreme Court on Tuesday said that there was lack of clarity in the Ministry of Ayush advisory on allowing homeopathic medical practitioners to prescribe even add-on or preventive treatment for COVID-19 patients.

The top court said that it would clarify the position and reserved its verdict on a plea challenging the Kerala High Court order which had said that AYUSH medical practitioners can prescribe government approved mixtures and tablets only as immunity booster for COVID-19 The Centre told the top court that medicines which are permitted to be prescribed by the Ministry of AYUSH (Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homeopathy) to COVID positive patients as an add-on treatment was allowed.

A bench of Justices Ashok Bhushan, R S Reddy and M R Shah said it would like to clarify the position on allowing homeopathic doctors to prescribe prophylactic interventions for improving the immunity of COVID-19 positive patients.

Solicitor General Tushar Mehta, appearing for Centre said that as per the advisory dated March 6, of Ministry of AYUSH, homeopathic practitioners cannot prescribe medicines for COVID-19 treatment but can prescribe drugs which are preventive in nature like for immunity boosting.

He said that an affidavit has been filed by the Ministry in this regard, which the bench took into record.

The top court was hearing an appeal against the Kerala High Court order of August 21.

The affidavit said, "Thus in the respectful submission of the answering respondent, prescription of the medication prescribed by the Ministry of AYUSH to COVID positive patients as an add-on treatment is permitted, and therefore, any contention to the contrary stating that homeopathic medical practitioner cannot prescribe any treatment to COVID-19 positive patients, even as an add-on to conventional treatment is liable to be rejected".

The Ministry said in its affidavit that, "It is stated that the only embargo is that the said medicines should not be administered or advertised as a cure but should be administered as preventive measure/immunity booster or as an add-on to the conventional treatment".

It said that the Ministry of AYUSH had clearly provided that administration of the medicine was to be done only as a preventive measure and the same should not be claimed as a treatment advice for the Coronavirus infection.

The affidavit said that the Ministry of AYUSH has clearly permitted the homeopathic medical practitioners to prescribe the drugs, as mentioned in the guidelines, as an add-on drug to the conventional treatment for patients who have been tested COVID positive and are undergoing conventional treatment.

The Ministry of AYUSH said that drugs which can be prescribed by a homeopathic medical practitioner are for preventive and prophylactic use, for symptom management of COVID-19 like illnesses; and add on interventions to the conventional care.

It said that all these medicines are to be administered as a preventive measure or as an add-on to the conventional treatment and should not be treated and/or prescribed as a cure.

The Ministry further said that its Guidelines for Registered Practitioners of respective system of AYUSH including Homoeopathy have been prepared by Director Generals of Research Councils and Directors of National Institutes with their team of experts and after vetting by the Interdisciplinary AYUSH Research and Development Task Force of Ministry of AYUSH.

"While noting and acknowledging the role played by homoeopathy medical practices for preventing the spread of diseases like Chikungunya, Dengue Fever, Japanese Encephalitis and Cholera with good results, the Ministry of Ayush prescribed the intervention and preventive management steps under the homeopathic practices at three stages-- preventive and prophylactic, symptom management of COVID- 19 like illnesses and add on interventions to the conventional car," it said.

On November 19, the top court had observed that everybody cannot be allowed to prescribe medicines.

The high court had passed the order on a plea which had sought a direction to the state authority to ensure that homoeopathic practitioners are immediately allowed to perform in accordance with the March 6 notification of the Ministry of AYUSH, which had said that state government shall take steps to adopt homoeopathic system among other systems of medicines in the fight against the menace of Coronavirus.

"Advisory of the Ministry of AYUSH is being followed by the government and tablets are given free of cost to those persons as immunity boosters.

As per the state medical protocol, COVID-19 affected persons should not be treated by anybody other than the government and those authorised by the government," the high court had noted in its order.

The high court had further noted that as per the medical protocol of the government, doctors practising in AYUSH medicines are not supposed to prescribe any medicines stating that it is curative for COVID-19 disease.

"However, as per the advisory, there is nothing prohibiting the qualified medical AYUSH practitioners to prescribe immunity booster mixture or tablets, as suggested by the Ministry of AYUSH, Government of India, New Delhi," it had said.

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SC says will clarify position on homeopathic preventive treatment for COVID, reserves verdict - The New Indian Express

With an overwhelming vote of 13 to 1, The Centers for Disease Control and Preventions (CDC) Advisory Committee on Immunization Practices (ACIP) has decided to put health care providers and long-term care residents at the top of the priority list for the impending COVID-19 vaccines, once they are US Food and Drug Administration (FDA) approved.

Yesterdays vote was formally recognizing the ACIP's previous recommendations on how to allocate the forthcoming COVID-19 vaccines. Healthcare personnel are part of phase 1A, the first group to be vaccinated. This group includes personnel who work in the following facilities including: hospitals, long-term care facilities, outpatient home health care, pharmacies, emergency medical personnel, and public health workers.

With the news that the Pfizer and BioNtechs vaccine was approved in the United Kingdom today, and with scheduled FDA meetings for both the Pfizer/BioNtech and Moderna vaccines later this month, the United States may have 2 approved COVID-19 vaccines in the next few weeks.

One of the biggest takeaways from last weeks meeting was the panel and participants taking part in the discussion wanted to inform the public and clinicians that the COVID-19 vaccines could bring on local side effects having vaccine recipients feeling flu-like.

The concern is that if people who get vaccinated and feel flu-like after the first dose, there might be reluctance to take a second dose a month later, thereby not giving that vaccinated person the needed immunity from the virus.

The ACIP includes 15 voting members responsible for making vaccine recommendations. Fourteen of the members have expertise in vaccinology, immunology, pediatrics, internal medicine, nursing, family medicine, virology, public health, infectious diseases, and/or preventive medicine; one member is a consumer representative who provides perspectives on the social and community aspects of vaccination.

In addition to the 15 voting members, ACIP includes eight ex officio members who represent other federal agencies with responsibility for immunization programs in the United States, and 30 nonvoting representatives of liaison organizations that bring related immunization expertise.

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CDC Committee Votes on Prioritizing US Population for COVID-19 Vaccine - Contagionlive.com

New Jersey, United States: Market Research Intellect has added a new report to its huge database of research reports, entitled Preventive Medicine Market Size and Forecast to 2027. The report offers a comprehensive assessment of the market including insights, historical data, facts, and industry-validated market data. It also covers the projections using appropriate approximations and methods.

Preventive Medicine Market Overview

The Preventive Medicine Market Report provides comprehensive data on market dynamics, market trends, product growth rate, and price. The Preventive Medicine market report has various facts and statistics assuming the future predictions of the upcoming market participants. In addition, it offers business security taking into account sales, profit, market volume, demand and market supply ratio. The in-depth study provides vital information related to market growth, driving factors, major challenges, opportunities, and threats that will prove to be very helpful for market participants in making upcoming decisions.

Preventive Medicine Market: Competitive Landscape

The Preventive Medicine Market report consists of the Competitive Landscape section which provides a complete and in-depth analysis of current market trends, changing technologies, and enhancements that are of value to companies competing in the market. The report provides an overview of sales, demand, futuristic costs and data supply as well as a growth analysis in the forecast year. The key vendors in the market that are performing the analysis are also clearly presented in the report. Their development plans, their growth approaches, and their merger and acquisition plans are also identified. Information specific to a keyword in each of these regions is also provided. This report also discusses the submarkets of these regions and their growth prospects.

Prominent players operating in the market:

Preventive Medicine Market Segmentation

The report contains the market size with 2019 as the base year and an annual forecast up to 2027 in terms of sales (in million USD). For the forecast period mentioned above, estimates for all segments including type and application have been presented on a regional basis. We implemented a combination of top-down and bottom-up approaches to market size and analyzed key regional markets, dynamics and trends for different applications.

Preventive Medicine Market Segment by Type:

Preventive Medicine Market Segment by Application:

Preventive Medicine Market Regional overview:

In the report, experts analyze and forecast the Preventive Medicine market on a global as well as regional level. Taking into account all aspects of the market in terms of regions, the focus of the report is on North America, Europe, Asia Pacific, the Middle East and Africa, and South America. The prevailing trends and various opportunities in these regions are studied that can convince the growth of the market in the forecast period 2020 to 2027.

Reasons to Buy the Preventive Medicine Market Report:

Outlook analysis of the Preventive Medicine market sector with current trends and SWOT analysis. This study evaluates the dynamics, competition, industrial strategies and strategies of the emerging countries. This report has a comprehensive guide that provides market insights and detailed data on each market segment Market growth factors and risks are presented. More precise information provision on the Preventive Medicine market for different countries. Provide visions on factors influencing the growth of the market. Market segmentation analysis, including quantitative and qualitative research considering the impact of economic and non-economic aspects Comprehensive company profiles with product offerings, important financial information and the latest developments.

If you have any custom requirements, please let us know and we will offer you the customized report as per your requirements.

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Preventive Medicine Market Size, Key Manufacturers, Demand, Application And Opportunities By 2027 - The Haitian-Caribbean News Network

Wed, Dec 2nd 2020 02:20 pm

By the American Heart Association

The menopause transition, the years leading up to menopause, is a time of increasing heart disease risk for women. Monitoring womens health and lifestyle, while integrating early intervention strategies for good cardiovascular health, are important, especially during midlife and during menopause to help prevent heart disease, according to a new scientific statement from the American Heart Association, Menopause Transition and Cardiovascular Disease Risk: Implications for Timing for Early Prevention, recently published in its flagship journal,Circulation.

Over the past 20 years, our knowledge of how the menopause transition might contribute to cardiovascular disease has been dramatically evolving, said Samar R. El Khoudary, Ph.D., M.P.H., FAHA, chair of the statement writing committee and associate professor of epidemiology at the University of Pittsburghs Graduate School of Public Health and the Clinical and Translational Science Institute. We have accumulated data consistently pointing to the menopause transition as a time of change in cardiovascular health. Importantly, the latest American Heart Association guidelines that are specific to women, which were published in 2011, did not include the data that is now available on menopause as a time of increased risk for womens heart health. As such, there is a compelling need to discuss the implications of this accumulating body of literature on this topic.

For many women, the menopause transition the change from the reproductive to the nonreproductive phase of life marked by changes in menstruation begins when they are in their late 40s to mid-50s. Before this transition, women produce estrogen, the female sex hormone, which may also have cardio-protective effects. When women go through the natural menopause transition, their ovaries stop producing as much estrogen. This can also occur through surgical menopause (a partial or full hysterectomy, which includes removal of one or both ovaries). Significant changes in a womans cardiometabolic and vascular health, which lead to higher heart disease risk, occur during the menopause transition.

Since the increase in heart disease risk during menopause is associated with a decrease in the production of the hormone estrogen, health care professionals and scientists have studied if hormone therapy might help reduce cardiovascular risk. There is research indicating potential cardiovascular benefits of certain combinations of hormone therapy when initiated in early but not late menopause. Further research is needed to evaluate the role of other hormone therapies, and how long these interventions impact cardio-metabolic health.

Additionally, some studies show the benefits of hormone therapy, including a decreased risk of type 2 diabetes and protection from bone loss, seem to outweigh the risks for most women in early menopause. Current recommendations from leading professional medical societies endorse the use of hormone therapy for women who have recently begun the menopause transition, with appropriate indications.

This scientific statement aims to raise awareness for both health care professionals and women about the significant adverse cardiovascular health changes accompanying midlife and the menopause transition and point out the importance of adopting prevention strategies early during this stage, El Khoudary said. As such, it emphasizes the importance of monitoring womens health during midlife and targeting this stage as a critical window for applying early intervention strategies that aim to maintain a healthy heart and reduce the risk of heart disease. Thus, health care professionals may consider an aggressive, prevention-based approach for women during this stage in their lives to decrease the probability of a future cardiovascular disease occurrence, such as heart attack or stroke.

In addition to summarizing research focused on the use of hormone therapy, the scientific statement provides an overview of risks related to the stages of menopause, age at menopause and lifestyle factors that affect womens risk during this time.

Key takeaways in the statement include the following:

Some of the common symptoms felt with menopause have a correlation with cardiovascular disease. Hot flashes and night sweats are associated with worse cardiovascular disease risk factor levels. Depression and sleep disturbances, linked in some studies to an increased risk of heart disease, are also common among women during this time.

Physiological changes during menopause, such as increased abdominal fat and visceral fat (body fat around the organs), are associated with a heightened risk of all-cause, cardiovascular disease and cancer mortality, even among those with normal body mass index levels.

Cholesterol levels,metabolic syndromerisk and vascular vulnerability appear to increase with menopause beyond the effects of normal aging. Metabolic syndrome is diagnosed when a person has three or more of the following measurements: abdominal obesity, high triglycerides, low HDL cholesterol (the good cholesterol), high blood pressure and/or high blood glucose levels (blood sugar).

Novel data show a reversal in the associations of HDL cholesterol (the good cholesterol) with heart disease risk over the menopause transition, suggesting higher good cholesterol levels may not consistently reflect good heart health in all stages of life in women.

Data about the use of cholesterol-lowering medications remains limited for women going through the menopause transition and requires further study so evidence-based recommendations can be developed.

Women who experience menopause at an earlier age have a higher risk of heart disease. A womans age at menopause can be influenced by factors such as length of menstrual cycle, poor cardiovascular risk profile during reproductive years and socioeconomic factors. Race and ethnicity also play a role, with many Hispanic and Black women experiencing menopause at younger ages.

Physical activity and nutrition may play a role in the timing of menopause for all women. Women who drink little to moderate amounts of alcohol may have later onset of menopause, and those who smoke cigarettes are likely to start menopause about a year earlier than non-smokers.

There is, however, limited information on what is ideal in terms of lifestyle changes (such as the AHAsLifes Simple 7) for women during menopause. Data does indicate that only 7.2% of women in menopause meet physical activity guidelines, and fewer than 20% of those women consistently maintain a healthy diet.

Lifestyle and behavioral interventions are critical to maintaining cardiovascular health and reduce heart disease. However, we do not have adequate randomized clinical trials testing these interventions specifically during the menopause transition, said Matthew A. Allison, M.D., M.P.H., FAHA, vice chair of the statement writing committee and professor and chief of the division of preventive medicine in the department of family medicine and public health at the University of California San Diego. Similarly, we need randomized clinical trials of therapeutic interventions, like cholesterol-lowering medications and menopause hormone therapy, in women who are transitioning through menopause. This at-risk population has not been the focus of previous clinical trials, thus leaving us with questions about how the results from these studies might apply to women during this earlier phase of menopause.

The scientific statement was developed by the writing group on behalf of the American Heart Associations prevention science committee of the council on epidemiology and prevention, and the Council on Cardiovascular and Stroke Nursing.

Co-authors and members of the writing committee additionally include Brooke Aggarwal, Ed.D., M.S., FAHA.; Theresa M. Beckie, Ph.D., FAHA; Howard N. Hodis, M.D., FAHA; Amber E. Johnson, M.D., M.S., M.B.A.; Robert D. Langer, M.D., M.P.H., FAHA; Marian C. Limacher, M.D., FAHA; JoAnn E. Manson, M.D., Dr.P.H., FAHA; and Marcia L. Stefanick, Ph.D., FAHA. Author disclosures are in the manuscript.

The American Heart Association is a relentless force for a world of longer, healthier lives.We are dedicated to ensuring equitable health in all communities.Through collaboration with numerous organizations, and powered by millions of volunteers, we fund innovative research, advocate for the public's health and share lifesaving resources.The Dallas-based organization has been a leading source of health information for nearly a century.Connect with us onheart.org,Facebook orTwitter,or by calling 1-800-AHA-USA1.

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Heart disease risk in women increases leading up to menopause; early intervention is key - Niagara Frontier Publications

(Hans Pennick | Associated Press file photo) Nurse Kathe Olmstead prepares a shot that is part of a possible COVID-19 vaccine, developed by the National Institutes of Health and Moderna Inc., in Binghamton, N.Y., in July 2020.

| Dec. 3, 2020, 6:31 p.m.

| Updated: Dec. 4, 2020, 1:35 a.m.

Front-line health care workers at five large hospitals will be the first people in Utah to receive the COVID-19 vaccine, officials for those hospitals confirmed Thursday.

Under the states distribution plan, people at higher risk of getting sicker from COVID-19 will start receiving the vaccine from February through May. The general public is expected to get the vaccine by June or July.

Gov. Gary Herbert, speaking Thursday at his weekly COVID-19 news briefing, said he hopes more vaccines could arrive even sooner.

We hopefully will have enough vaccines that by springtime March, April, May of this year everybody who wants to have a vaccine will be able to have a vaccine, he said. Thats going to help us slow the spread and give us relief, and start to help us recover and have more normal socialization.

The first batch of vaccines will be distributed to the five Utah hospitals, so they can be given out as soon as the U.S. Food and Drug Administration approves an emergency use authorization of the vaccine which is expected the week of Dec. 14.

The five hospitals were chosen, Dascomb said, because they are handling a large number of the states COVID-19 patients and because they have the supercold freezers needed to store the Pfizer vaccine at temperatures of 80 below zero Celsius.

The Pfizer product is a very fragile and unstable virus vaccine, and has to be handled very carefully, Mayer said. Weve got the minus-80 freezers. Weve got the backups to the backups.

The health department estimates there are about 126,000 health care workers in Utah, Hudachko said. The state doesnt know how many of those would receive the first batch of vaccines.

Those front-line workers include doctors and nurses who treat COVID-19 patients, specialists at high-risk of exposure (such as anesthesiologists), and for hospital housekeepers who come in contact with infected materials.

Housekeepers, Mayer said, have been the hardest hit during this pandemic.

Mayer said University Hospital expects to dole out between 500 and 750 doses a day, and Dascomb said the four Intermountain hospitals will be working on a similar schedule. They said the hospitals would work to schedule vaccinations so workers at the same hospital units werent all treated the same day and that the shots would be given so workers could take a day or two off if they develop side effects.

The trial studies for the Pfizer vaccine and a second vaccine made by Moderna, expected to get FDA approval in late December, have shown few side effects, said Dr. Andrew Pavia, chief of pediatric infectious disease at University of Utah Health. That doesnt mean side effects wont show up when thousands and millions of people get the vaccines, he said.

Well be keeping very close eyes on the long-term safety, Pavia said. Its a relatively new vaccine, and we dont have years of experience with it.

Pavia noted that the odds of serious side effects are one in thousands, while the odds of dying if one is infected with the coronavirus is 1 in 150. The benefits of preventing the disease, he said, will outweigh the risks of taking the vaccine.

Health care workers at Intermountain and University of Utah Health wont be required to take the vaccine, officials at both hospital systems said.

Workers will be presented with the data, so they can make an informed choice, said Dr. Tamara Sheffield, medical director of Intermountains community health and prevention department.

Herbert said the state government has no plans to mandate COVID-19 vaccines when they become available to the public.

We think that most of the people in Utah will want to have one, Herbert said, to protect themselves and their loved ones.

Businesses, Herbert said, likely could require their employees to get vaccinated. It would be entirely within their abilities, their constitutional rights as an employer, to say, If youre going to come to work for me, I want to make sure you have the vaccine, so we dont get people sick here on the job.

Both the Pfizer and Moderna vaccines require two doses, taken weeks apart. The plan is to distribute all the Pfizer doses immediately, with more shipments expected to arrive in the coming weeks to cover the second dose.

Mayer said the health department has assured the hospitals that they will receive enough vaccines to cover the second doses.

Pavia noted that the vaccine landscape is constantly changing. A third vaccine, developed by AstraZeneca and Oxford University, is in clinical trials. And both Pfizer and Moderna, he said, are starting trials for 12- to 17-year-olds.

The distribution is complex, and its evolving, Pavia said. By the time spring rolls around, we may have three or four vaccines.

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Here's how Utah's first vaccinations will be distributed and when you will get yours - Salt Lake Tribune

RESEARCH TRIANGLE PARK, N.C., Nov. 30, 2020 (GLOBE NEWSWIRE) -- BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX) today announced the journal Allergy has published data from the APeX-J trial, a randomized, placebo-controlled trial conducted in Japan evaluating oral, once-daily berotralstat for the prophylactic treatment of hereditary angioedema (HAE).

The APeX-J trial met its primary endpoint of a reduction in the rate of HAE attacks for berotralstat 150 mg compared to placebo during the 24-week period (p=0.003). Berotralstat was safe and generally well-tolerated in the trial.

These results are consistent with the global phase 3 APeX-2 trial, where berotralstat 150 mg also reduced the rate of HAE attacks compared to placebo (p<0.001) and was safe and generally well-tolerated.

APeX-J is the first placebo-controlled trial of an HAE medicine conducted in Japan and the berotralstat data are very exciting for patients, who currently have no approved prophylactic treatment options. Based on the safety and efficacy profile, I believe berotralstat, if approved, would be an important advancement in HAE management for Japanese patients, said Dr. Isao Ohsawa, president of Saiyu Soka hospital and principal investigator of the APeX-J trial.

Dr. Ohsawa and the study authors note that HAE is estimated to affect 2,500 patients in Japan and the recognition of HAE by physicians is low. Although two on-demand treatments are approved, no therapies are currently approved for long-term prophylaxis in Japan.

Berotralstat would be the first approved prophylactic therapy for HAE patients in Japan and we believe there is a significant opportunity for berotralstat to accelerate the diagnosis of HAE patients and dramatically improve the quality of life for patients, said Jon Stonehouse, president and chief executive officer of BioCryst.

A new drug application (JNDA) is under review in Japan for approval of oral, once-daily berotralstat for the prophylactic treatment of HAE. Berotralstat is being reviewed under Sakigake designation and the company expects a decision on approval in December 2020.

Torii Pharmaceutical, Co., Ltd. is BioCrysts commercial partner in Japan for berotralstat.

About BioCryst Pharmaceuticals

BioCryst Pharmaceuticals discovers novel, oral, small-molecule medicines that treat rare diseases in which significant unmet medical needs exist and an enzyme plays a key role in the biological pathway of the disease. BioCryst has several ongoing development programs including ORLADEYO (berotralstat), an oral treatment for hereditary angioedema, BCX9930, an oral Factor D inhibitor for the treatment of complement-mediated diseases, galidesivir, a potential treatment for COVID-19, Marburg virus disease and Yellow Fever, and BCX9250, an ALK-2 inhibitor for the treatment of fibrodysplasia ossificans progressiva. RAPIVAB (peramivir injection), a viral neuraminidase inhibitor for the treatment of influenza, is BioCryst's first approved product and has received regulatory approval in the U.S., Canada, Australia, Japan, Taiwan, Korea and the European Union. Post-marketing commitments for RAPIVAB are ongoing. For more information, please visit the Company's website at http://www.BioCryst.com.

Forward-Looking Statements

This press release contains forward-looking statements, including statements regarding future results, performance or achievements. These statements are identified by use of terms such as believe, will, would, expect, and similar words, although some forward-looking statements may be expressed differently. These statements involve known and unknown risks, uncertainties and other factors which may causeactual results, performance or achievements to be materially different from any future results, performances or achievements expressed or implied by the forward-looking statements. These statements reflect our current views with respect to future events and are based on assumptions and are subject to risks and uncertainties. Given these uncertainties, you should not place undue reliance on these forward-looking statements. Some of the factors that could affect the forward-looking statements contained herein include: the ongoing COVID-19 pandemic, which could create challenges in all aspects of BioCrysts business, including without limitation delays, stoppages, difficulties and increased expenses with respect to BioCrysts and its partners development, regulatory processes and supply chains, negatively impact BioCrysts ability to access the capital or credit markets to finance its operations, or have the effect of heightening many of the risks described below or in the documents BioCryst files periodically with the Securities and Exchange Commission; developing and commercializing ORLADEYO or any HAE product candidate may take longer or may be more expensive than planned; BioCryst may not be able to enroll the required number of subjects in planned clinical trials of product candidates; BioCryst may not advance human clinical trials with product candidates as expected; the FDA, EMA, PMDA or other applicable regulatory agency may require additional studies beyond the studies planned for product candidates, may not provide regulatory clearances which may result in delay of planned clinical trials, may impose certain restrictions, warnings, or other requirements on product candidates, may impose a clinical hold with respect to such product candidates, or may withhold or delay market approval for product candidates; product candidates, if approved, may not achieve market acceptance; BioCrysts ability to successfully commercialize its product candidates, manage its growth, and compete effectively; and risks related to the international expansion of BioCrysts business. Please refer to the documents BioCryst files periodically with the Securities and Exchange Commission, specificallyBioCrystsmost recent Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, and Current Reports on Form 8-K, all of which identify important factors that could cause the actual results to differ materially from those contained inBioCrystsforward-looking statements.

BCRXW

Contacts:John Bluth+1 919 859 7910jbluth@biocryst.com

Catherine Collier Kyroulis+1 917 886 5586ckyroulis@biocryst.com

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Allergy Publishes Results from BioCryst's APeX-J Trial of Oral, Once-Daily Berotralstat for the Prevention of HAE Attacks - GlobeNewswire