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Cold enough for you? This typical Midwest winter greeting pretty much sums up this weeks weather, but it should serve as a reminder, too it can be too cold.

As the temperature plunges and cold winds blow, so does the risk of frostbite. Skin exposed to extreme cold can develop frostbite in as little as five minutes, said FHN Podiatrist Roland Tolliver. Fingers in gloves and toes in boots can develop frostbite, too.

Though frostbite can happen to anyone, some conditions can make a person more susceptible: if you have diabetes, take blood thinners or smoke, your circulatory system may not work as efficiently or you may suffer from neuropathy, which means you have lost some feeling in your extremities. Poor circulation and neuropathy put you at higher risk for developing frostbite.

Skin that is cold and wet, like fingers in damp gloves and toes in wet socks, is even more susceptible to frostbite.

Danger Signs

Dr. Tolliver said one of the first signs of frostbite can be skin that is itchy, burnsor is numb. The skin also may turn white or greyish yellow, and as more damage occurs, feel waxy or hard. At its most severe, frostbite can cause blistering and even gangrene.

If you notice any of the signs of frostbite, go inside or get warmed up as quickly as possible.

Once you are in where its warm, remove any wet clothing and look closely at the affected area. You might see red skin and feel some pain or numbness. As you warm up, you may notice the area feels tingly that means the circulation is returning.

You can help speed the warming process by soaking the affected area in lukewarm not hot water. (The water temperature should be between 105-110 F.) Soak the area until the skin is back to its normal color and you dont feel any numbness.

A warm beverage like tea or cocoa can help you feel warmed up, too, but avoid any alcoholic beverages while your body is recovering from the cold. If you are feeling pain, an over-the-counter pain reliever may help.

If your pain increases or your skin doesnt return to its normal color, bundle up (in dry clothes leave the soggy gloves and boots behind) and head for the emergency department for medical attention.

Warm and dry

If youre planning to spend a lot of time outside in the cold, you probably know to wear long underwear and a turtleneck to help keep you warm.

Well-planned layers can help prevent frostbite, too: wear a thin pair of socks to pull moisture away from your feet underneath a thicker pair of socks for warmth. If you know youll be handling wet snow, wear waterproof gloves or layer pairs to keep your fingers as dry as possible.

Hand warmers and other gadgets to tuck in your pockets or shoes are easy to find this time of year, but people with poor circulation or who have lost some feeling in their extremities should be cautious using these items: if you cant feel your fingers or toes getting too cold, you likely wont be able to tell if they get too warm, either, and that can cause tissue damage, too.

The key to staying safe from frostbite, Tolliver said, is just to be aware of any signals your body may be sending. Take a warm-up break from shoveling or sledding when you need one with these temperatures, the snow isnt going anywhere!

Roland Tolliver, DPM, FACFAS, is a podiatrist at FHN. Hear more of his Dial-a-Doc interview on this topic at http://www.fhn.org/newsradio.asp.

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FHN Health Column: Be careful in the cold protect your skin from frostbite - Freeport Journal-Standard

100 types of joint pain

Arthritis is an inflammation of the joints that can cause debilitating joint pain. There are more than 100 different kinds of arthritis and related conditions.

Arthritis affects more than 50 million adults and 300,000 children in America, according to the Arthritis Foundation. The causes and treatment options available vary from one type of arthritis to another.

To find the best treatment and management strategies, its important to determine the type of arthritis you have. Read on to learn about the types and what their differences are.

Osteoarthritis (OA), also called degenerative arthritis, is the most common type of arthritis. It affects about 27 million people in the United States, according to the Arthritis Foundation.

With OA, cartilage in your joints breaks down, eventually causing your bones to rub together and your joints to be inflamed with subsequent pain, bone injury, and even bone spur formation.

It may occur in just one or two joints, on one side of the body. Age, obesity, injuries, family history, and joint overuse can raise your risk of developing it. Common symptoms include:

To learn if you have OA, your doctor will take your medical history and conduct a physical exam. They may order X-rays and other imaging tests. They may also aspirate an affected joint, taking a sample of fluid from inside to check for infection.

Rheumatoid arthritis (RA) is a type of autoimmune disease in which your body attacks healthy joint tissue. The Arthritis Foundation estimates that about 1.5 million adults in the United States have RA. Nearly three times as many women have RA than men.

Common symptoms of RA include morning stiffness and joint pain, typically in the same joint on both sides of your body. Joint deformities can eventually develop.

Additional symptoms may also develop in other parts of your body including the heart, lungs, eyes, or skin. Sjgrens syndrome frequently occurs with RA. This condition causes severely dry eyes and mouth.

Other symptoms and complications include:

Your doctor cant use any single test to determine if you have RA. To develop a diagnosis, theyll likely take a medical history, conduct a physical exam, and order X-rays or other imaging tests.

Your doctor may also order a:

These tests can help your doctor learn if you have an autoimmune reaction and systemic inflammation.

Juvenile arthritis (JA) affects about 300,000 children in the United States have JA, according to the Arthritis Foundation.

JA is an umbrella term for several types of arthritis that affect children. The most common type is juvenile idiopathic arthritis (JIA), formerly known as juvenile rheumatoid arthritis. This is a group of autoimmune disorders that can impact childrens joints.

JIA starts to occur in children younger than 16 years old. It can cause:

Months of aching joints, swelling, stiffness, fatigue, and fevers may indicate juvenile idiopathic arthritis.

Other less common forms of JA include:

Ankylosing spondylitis (AS) and other types are autoimmune conditions that can attack the locations where tendons and ligaments attach to your bone. Symptoms include pain and stiffness, especially in your lower back.

Your spine will likely be affected the most, as AS is the most common of these conditions. It usually affects mainly the spine and pelvis but can affect other joints in the body.

Other spondyloarthropathies can attack peripheral joints, such as those in your hands and feet. In AS, bone fusion may occur, causing deformation of your spine and dysfunction of your shoulders and hips.

Ankylosing spondylitis is hereditary. Most people who develop AS have the HLA-B27 gene. Youre more likely to have this gene if you have AS and youre Caucasian. Its also more common in men than women.

Other spondyloarthritic diseases are also associated with the HLA-B27 gene, including:

Systemic lupus erythematosus (SLE) is another autoimmune disease that can affect your joints and many types of connective tissue in your body. It can also damage other organs, such as your:

SLE is more common among women, particularly those with African or Asian ancestry. Common symptoms include joint pain and swelling.

Other symptoms include:

You may experience more severe effects as the disease progresses. SLE affects people differently, but starting treatment to try to get it under control as soon as possible and working with your doctor can help you manage this condition.

Gout is a form of arthritis caused by the accumulation of urate crystals inside your joints. High levels of uric acid in your blood may put you at risk of gout.

An estimated 3.9 percent of American adults have gout thats 5.9 percent of American men and 2 percent of American women. Age, diet, alcohol use, and family history can affect your risk of developing gout.

Gout can be incredibly painful. A joint at the base of your big toe is most likely to be affected, although it can potentially affect other joints. You may experience redness, swelling, and intense pain in your:

An acute attack of gout can come on strong within a few hours during the course of a day, but the pain can linger for days to weeks. Gout can become more severe over time. Learn more about the symptoms of gout.

Infectious arthritis is an infection in one of your joints that causes pain or swelling. The infection can be caused by bacteria, viruses, parasites, or fungi. It can start in another part of your body and spread to your joints. This kind of arthritis is often accompanied by a fever and chills.

Reactive arthritis can occur when an infection in one part of your body triggers immune system dysfunction and inflammation in a joint elsewhere in your body. The infection often occurs in your gastrointestinal tract, bladder, or sexual organs.

To diagnose these conditions, your doctor can order tests on samples of your blood, urine, and fluid from inside an affected joint.

Up to 30 percent of those with psoriasis will also have psoriatic arthritis (PsA). Usually, youll experience psoriasis before PsA sets in.

The fingers are most commonly affected, but this painful condition affects other joints as well. Pink-colored fingers that appear sausagelike and pitting and degradation of the fingernails may also occur.

The disease may progress to involve your spine, causing damage similar to that of ankylosing spondylitis.

If you have psoriasis, theres a chance you could also develop PsA. If PsA symptoms start to set in, youll want to see your doctor to treat this as early as you can.

Many other forms of arthritis and other conditions can also cause joint pain. A few examples include:

If youre experiencing joint pain, stiffness, or other symptoms, talk to your doctor. They can help diagnose the cause of your symptoms and recommend a treatment plan. In the meantime, find relief from arthritis pain naturally.

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What Type of Arthritis Do You Have? Understanding Symptoms

Arthritis is a painful rheumatic condition that causes joint inflammation. There are many different types of arthritis that can affect the joints and other areas of the body and cause similar symptoms, such as pain, swelling, and stiffness.

There are more than 100 different types of arthritis. Some common types of arthritis include osteoarthritis (OA), rheumatoid arthritis (RA), and psoriatic arthritis (PsA).

Below, we explore these conditions, as well as other diseases that can present with arthritis. We also discuss potential treatment and when to seek medical guidance.

According to the Centers for Disease Control and Prevention (CDC), OA affects over 32.5 million adults in the United States.

Symptoms of OA include:

People often experience OA symptoms in the hips, hands, and knees.

The following increase the likelihood of developing OA:

Learn more about OA here.

RA is an autoimmune condition that causes painful swelling and inflammation in the joints. It typically affects the hands, wrists, and feet.

RA does not only affect joints. It can also cause problems in other organs of the body, including the heart, lungs, and eyes.

While some people experience a sustained progression of the disease, the intensity of symptoms usually comes and goes. Symptoms may include:

Another characteristic of RA is symmetrical involvement. This means pain and signs of inflammation occur on both sides of the body and in the same joints.

RA can cause lasting tissue damage, which can lead to:

Some people who have RA may also need assistance walking.

Some RA risk factors include:

Learn more about RA here.

PsA is an autoimmune condition.

Symptoms of PsA include:

PsA joint involvement is asymmetric, affecting different joints on either side of the body.

This type of arthritis can develop in people with a skin condition called psoriasis, which causes scaly, flushed, or silvery patches of skin. These patches can look different depending on a persons skin color.

Learn more about psoriasis on black skin here.

Researchers still do not fully understand what causes this form of arthritis. However, having a family history of PsA may increase a persons risk of developing this condition.

Learn more about PsA here.

Gout is a type of arthritis that causes painful swelling, often in a single joint at a time.

Symptoms of gout can flare up and go away quickly. They include:

Swelling is common in the big toe. Often, it also affects the knee or ankle joint.

A person may be at higher risk of developing gout if they:

Health conditions that may lead to gout include:

Gout may also occur due to metabolic syndrome, which is not a condition in itself. It refers to a number of characteristics, diseases, or habits that can make a person more likely to experience other health conditions, such as heart disease, stroke, or diabetes.

Learn more about gout here.

This chronic illness is an autoimmune condition that commonly affects females aged 1544 years.

Lupus is not a type of arthritis in itself. However, arthritis is one of the most common symptoms of this condition.

One symptom of lupus is the characteristic butterfly rash that can develop on the face. Other rashes can also develop on the arms, hands, and face. Rashes can worsen after sun exposure.

While symptoms may differ from person to person, they generally include:

Learn more about lupus here.

Juvenile arthritis, also known as childhood arthritis, affects children or even infants.

Symptoms of juvenile arthritis include:

There is no known cause of childhood arthritis. It appears to affect children regardless of race, age, or background.

Learn more about juvenile arthritis here.

Reaching a definitive diagnosis may take time, because many types of arthritis are similar or resemble other conditions.

Typically, a doctor will first check a persons medical and family history. They will also ask about symptoms and perform a physical exam. They may run tests such as:

Arthritis management depends on the type of arthritis. There are different forms of treatment available.

Medical treatment for arthritis may involve:

Surgery may not be necessary for everyone with arthritis. However, it can benefit certain complications of arthritis that result in malalignment of joints and functional limitations due to damaged joints. It can also help with intractable pain, which is when a person experiences pain that is difficult to treat or manage.

Common surgeries for arthritis include:

Physical therapy can be a great option for people with arthritis. It can help ease pain or increase activity.

Behavioral changes that can help with arthritis may include:

Some people find certain home remedies helpful in relieving pain and swelling from certain types of arthritis. These may include:

If a person has experienced joint symptoms that last more than 3 days, they should seek treatment from a healthcare professional.

Similarly, if a person has joint symptoms at different times within a month, they should also contact a doctor.

Medications and other treatments can help a person manage chronic symptoms, such as pain and swelling.

Pain will come and go with many types of arthritis. However, even if the pain resolves, a person should still seek treatment.

It is important to treat arthritis early. If left untreated, some types of arthritis may worsen over time and cause permanent disability.

Arthritis is a painful condition that causes joint inflammation.

Different types of arthritis can cause similar symptoms. It is vital to get the correct diagnosis, as it can help determine most effective treatment options.

The right treatment may also prevent future complications and help a person live a more active life.

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Common types of arthritis: Location, causes, treatment, and more - Medical News Today

February 9, 2021

After watching a close family member suffer with rheumatoid arthritis, Vidyanand Anaparti [PhD/15] was motivated to make a difference.

In 2015, Anaparti joined Max Rady College of Medicine professor Dr. Hani El-Gabalawys research program which focuses on discovering the origins of rheumatoid arthritis. Since then, Anapartis work has been recognized and was listed as one of the Arthritis Societys Top 10 Research Advances of 2020.

I understand the pain my family member goes through every single day, said Anaparti, a postdoctoral fellow in internal medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences. If Im able to prevent at least one person from getting the condition, I will think that my research is successful.

When Anaparti joined El-Gabalawys team, he was tasked with researching the cellular switches that turn genes on and off.

Anaparti studied First Nations people, who have elevated rates of rheumatoid arthritis, to figure out what factors precede or aid in the onset of the chronic disease. One of the factors is cellular switches called microRNAs. Anaparti was interested in people who had levels of anti-citrullinated protein antibody (ACPA), a type of autoantibody whose levels are routinely measured to assess the risk of developing rheumatoid arthritis.

Anaparti found that the first-degree relatives of patients with rheumatoid arthritis have altered levels of certain microRNAs and these individuals exhibit a microRNA expression pattern similar to rheumatoid arthritis patients. Anaparti found that altered microRNA expression in ACPA-positive first-degree relatives is consistent over time and how theyre expressed varies depending on the type of immune cell.

We were able to detect these microRNAs in people years before they developed rheumatoid arthritis, Anaparti said. We have the potential to identify individuals before they become a patient.

Another discovery that Anaparti made was that the methylation, a cellular switch, of specific genes in rheumatoid arthritis patients was different from healthy people and might play a crucial role in the diseases development. He also identified that the levels of some metabolic markers are shifted in at-risk, ACPA-positive first-degree relatives of people with the chronic inflammatory disorder.

Anaparti also found that methylation and microRNAs have a direct influence on the expression of certain genes involved in rheumatoid arthritis.

He has published his findings in reputed journals, including Arthritis & Rheumatology and Arthritis Research & Therapy. His research has been funded by Research Manitoba, Arthritis Society of Canada and Health Sciences Centre Foundation.

Vidyanand is a bright and creative scientist who is meticulous in his experimental approach, El-Gabalawy said. He is an integral part of our human immunology research team and is an excellent mentor for trainees in our lab.

Using data generated from Anapartis research over the last five years, El-Gabalawys team has secured funding from the Canadian Institutes of Health Research for a project focused on rheumatoid arthritis in First Nations people that will include a clinical trial to see whether the combination of turmeric, omega-3 and vitamin D can reduce the risk of rheumatoid arthritis.

Currently in the lab, Anaparti is working on advancing his findings on microRNA by trying to understand their biological role.

The ultimate objective is to prevent people from getting rheumatoid arthritis, Anaparti said. All of this research, all of this understanding, is a step forward in the right direction.

Matthew Kruchak

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UM Today | Rady Faculty of Health Sciences | On the path to preventing rheumatoid arthritis - UM Today

In the UK, more than 10 million people have arthritis or other, similar conditions that affect the joints. Osteoarthritis is the most common type of arthritis in the UK, affecting nearly nine million people. As the NHS explains, osteoarthritis initially affects the smooth cartilage lining of the joint.

A review published in the journal Dovepress aimed to summarise the anti-osteoarthritic effects of curcumin derived from clinical and preclinical studies.

Many clinical trials had been conducted to determine the effectiveness of curcumin in osteoarthritic patients.

According to the review, patients with osteoarthritis showed improvement in pain, physical function, and quality of life after taking curcumin.

To arrive at this conclusion, a total of 15 relevant clinical studies on the effects of curcumin supplementation on osteoarthritic patients were retrieved.

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While some food items are anti-inflammatory, others can make osteoarthritis worse so are best to be avoided.

According to the British Dietetic Association (BDA), Several popular diet books on arthritis advocate avoiding foods such as dairy products or the nightshade vegetables (tomatoes, potatoes, bell peppers and aubergines).

"Though there is some evidence that food avoidance may help rheumatoid arthritis patients, there is no evidence of benefit in osteoarthritis patients," says the BDA.

Diet is not the only remedy for osteoarthritis - exercise can help too.

Although it may seem counterintuitive, research shows that people can and should exercise when they have osteoarthritis.

"In fact, exercise is considered the most effective, non-drug treatment for reducing pain and improving movement in patients with osteoarthritis," explains the Arthritis Foundation (AF).

Different types of exercise play a role in maintaining and improving the ability to move and function.

According to the AF, walking and aquatic exercises are particularly good for most people with osteoarthritis.

As the health body explains, aerobic exercise also reduces fatigue and builds stamina, while helping control weight by increasing the number of calories the body uses.

This is important because excess weight can place pressure on the joints, amplifying symptoms.

Examples of this type of exercise includes walking, jogging, bicycling, swimming or using the elliptical machine.

Other exercises for osteoarthritis include:

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Arthritis treatment: Curcumin improves pain, physical function, and quality of life - Express

Cases of long Covid could put the NHS under pressure for many years to come, an expert has warned.

Danny Altmann, professor of immunology at Imperial College London, said people experiencing long-term symptoms of coronavirus could become a burden on the health service equivalent to arthritis.

The i newsletter latest news and analysis

Prof Altmann said arthritis is currently the biggest cause on our NHS time and expenditure but said long Covid risked eclipsing it by taking up even more resources.

He was asked on Times Radio whetherlongCovidwould become less of an issue as fewer people become severely ill from coronavirus, to which he replied: Probably not.

I think for me the rule of thumb at the moment looking at thelongCovidcases is theres no absolute correlation with how severe your initial attack was, Prof. Altmann added.

So theres plenty of people out there who barely know they had it and never had a PCR test or antibody test who are suffering massively still fromlongCovid.

It really worries me, the kind of burden Ive been suggesting is equivalent to our NHS burden of arthritis, which is one of the biggest cause on our NHS time and expenditure.

Its a real thing to worry and think about for the future, for patients and healthcare planning.

Long-Covid patients have complained of persistent fatigue, shortness of breath and problems with memory lasting for months after they were initially infected.

And Prof Altmann said the number of patients reporting symptoms ofCovid-19 weeks after becoming ill could be as high as 20 per cent.

He added that a figure of one in 20 people sufferinglongCovid, reported in October by Kings College London, is lower than what is now being reported.

Many people would have 10-20 per cent as their range if you look at the papers on how many people are still reporting significant symptoms several months afterwards, he continued.

Prof Altmann urged the Government to consider openinglongCovidclinics to dealing with the increased pressure on the NHS.

He recently made the case at a World Health Organisation meeting for mechanisms to be in place for people to be referred to relevant specialists.

The point I was trying to make was really a call to arms for some really good solid research and mechanisms here, because theres no point just having the banner above the clinic if we havent got the doctors to sit in them, he continued.

Prof Altmann warned that there is no absolute correlation between severe illness andlongCovid.

He added: Theres plenty of people out there who barely know they had it and never had a PCR test or antibody test who are suffering massively still fromlongCovid.

Additional reporting byPress Association

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Long Covid could create burden on NHS equivalent to arthritis - iNews

Background:This study aimed to investigate the relationship of serum JNK pathway-associated phosphatase (JKAP) expression with rheumatoid arthritis (RA) risk and clinical features, also to explore the longitudinal change of JKAP during etanercept treatment and its relationship with etanercept treatment response in RA patients.

Methods:A total of 87 RA patients and 44 healthy controls (HCs) were enrolled; then, their JKAP expression in serum was determined by enzyme-linked immunosorbent assay (ELISA). Among 87 RA patients, 42 cases further received the 24-week etanercept treatment; then, their JKAP level in serum (detected by ELISA) and clinical response (evaluated by disease activity score in 28 joints (DAS28) score) were evaluated at week 4 (W4), week 12 (W12), and week 24 (W24) after initiation of etanercept treatment.

Results:JKAP expression was decreased in RA patients compared to HCs, which disclosed a good predictive value for RA risk. JKAP expression was negatively associated with tender joint count, swollen joint count, erythrocyte sedimentation rate, C-reactive protein, and DAS28 in RA patients, respectively. For RA patients who received 24-week etanercept treatment, their clinical response rate was 0.0%, 33.3%, 50.0%, and 69% at W0, W4, W12, and W24, respectively. Importantly, JKAP was gradually increased during etanercept treatment, whose longitudinal elevation positively related to etanercept treatment response in RA patients.

Conclusion:Circulating JKAP links with decreased RA risk and mild disease activity, whose longitudinal elevation positively relates to etanercept treatment response.

Keywords:JNK pathway-associated phosphatase; disease risk; disease severity; etanercept treatment; rheumatoid arthritis.

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JNK pathway-associated phosphatase associates with rheumatoid arthritis risk, disease activity, and its longitudinal elevation relates to etanercept...

Arthritis has been one of the most common health conditions in Canada for years, affecting people of all ages with symptoms including joint stiffness and painful inflammation. While there is no known cure, researchers are hoping to find more effective ways to treat and manage arthritis. The Arthritis Society of Canada compiles a list of the top 10 research advances each year, highlighting breakthroughs with promising results. The list for 2020 includes two McGill-led projects supervised by Dr. Hosni Cherif and Dr. Ins Colmegna.

Zombie cells and spinal degradation

Osteoarthritis is one of the most common forms of arthritis worldwide, and is caused by the deterioration of joint cartilagetissues that cushion the ends of bones. Cherif, a postdoctoral fellow in McGills Faculty of Medicine and Health Sciences, led a research project on spinal osteoarthritis.

My research goal is to understand how intervertebral discs and joints degenerate leading to axial osteoarthritis, and the associated chronic pain, Cherif wrote in an email to The McGill Tribune.

In particular, Cherif studied the role of senescent cells, often known as zombie cells, which permanently stop dividing but continue to age and evade death.

Cytokines, also known as cellular signalling molecules, are typically involved in aiding the immune response at a site of inflammation, but the accumulation of these molecules can cause degradation of the spine.

[The] accumulation of senescent cells increases cytokine production and inflammationleading to the development ofintervertebral disc degeneration, Cherif wrote.

Cherifs team identified a synthetic drug, RG-7112, and a natural compound, o-Vanillin, capable of eliminating zombie cells while allowing healthy ones to proliferate. The combination of these molecules has the potential to target inflammation in the spine, thereby reducing the associated chronic pain.

This will lead to better management or the alleviation of persistent pain to improve the quality of life of patients with osteoarthritis, Cherif wrote.

Currently, Cherif is expanding his research in drug discovery to treat spinal osteoarthritis by testing out the signalling pathways of other senotherapeutic agents, molecules that specifically target cellular senescence.

Understanding the mechanism of cellular senescence and disc degradation will facilitate [the] development of novel disease-modifying drugs, Cherif wrote.

The more the better: High dose vaccine protection

Rheumatoid arthritis (RA) is an autoimmune type of arthritis in which the immune response mistakenly targets host cells, causing joint damage and inflammation. This makes patients more vulnerable to the adverse effects of viruses such as influenza.

Colmegna, an assistant professor working in the Division of Rheumatology at the McGill University Health Centre, led a study focussing on the implications of influenza infections in RA patients.

Specifically, Colmegna studied the effect on antibody production of a standard dose of the influenza vaccine versus a high dose in those with RA. Antibodies are molecular markers that recognize and bind to foreign invaders, signalling their presence to the immune system and initiating an immunological response.

The findings of our study indicate that compared with the standard dose influenza vaccine, RA patients who receive the high-dose are two to three times more likely to generate protective antibodies against the influenza virus, Colmegna wrote in an email to The McGill Tribune. This may be associated with a reduced risk of developing influenza.

By increasing the likelihood of generating more antibodies against influenza, the higher dose increases the effectiveness of the bodys response to infection.

This study is the first of its kind to show that it is possible for those with RA to achieve better protection against influenza by using an existing high dose vaccine.

Canadian guidelines recommend that RA patients receive an annual standard dose influenza vaccine, Colmegna wrote. However, many RA patients do not generate protective antibodies post-vaccination [.] With this approach, a larger number of patients with rheumatoid arthritis might be protected against influenza, a disease that in these patients is associated with significant morbidity and mortality.

Colmegna hopes that her research findings will increase the availability of high dose vaccines to better protect RA patients against the influenza virus.

The rest is here:
McGill researchers are shaping the future of arthritis treatment - McGill Tribune

Rheumatoid Arthritis Drugs Market

The global Rheumatoid Arthritis Drugs Market report look through various tendencies, obstructions, and challenges faced by the key competitors of Rheumatoid Arthritis Drugs market. The report has been prepared in consideration of the major outcomes and consequences of the market.

Rheumatoid Arthritis Drugs market was valued at USD XXX million in 2019, and it is expected to reach a value of USD XXX million by 2026, at a CAGR of XX % over the forecast period 2021-2026. Correspondingly, the forecast analysis of Rheumatoid Arthritis Drugs industry comprises of Asia, North America, South America, Middle East and Africa, Europe, with the production and revenue data in each of the sub-segments.The Merck aims at producing XX Rheumatoid Arthritis Drugs in 2020, with XX % production to take place in global market, Novartis accounts for a volume share of XX %.

This report examines the Rheumatoid Arthritis Drugs market status and the potential of global and major regions, from angles of players, product regions and end Application/industries; this report assesses the key players in global and major regions and classifies the Rheumatoid Arthritis Drugs market by product and Application/end industries.

Merck, Novartis, Pfizer, J&J, BMS, Abbvie, Boehringer Ingelheim, AstraZeneca, MedImmune, Takeda, Biogen Idec, Celgene, Bristol-Myers Squibb, Celltrion

HospitalsClinicsHome CareOther

Major Type of Rheumatoid Arthritis Drugs CoveredNSAIDsDMARDsCorticosteroidsAnalgesicsOther

The major objective of this Rheumatoid Arthritis Drugs Industry report is to assist the user get to know the market, understand its definition, segmentation, influential trends, market potential, and the challenges that the market is going through. Profound researches and analysis over the course of the formulation of the report. This report will help the users to understand the market in detail. The facts and the information in respect to the Rheumatoid Arthritis Drugs market are taken from authentic sources as like journals, websites, annual reports of the companies, and others and were reviewed and validated by the industry experts. The data and facts are illustrated in the report using graphs, pie charts, diagrams, and other pictorial representations. This enhances the visual representation and assures understanding the facts in a better way.

The Regional and country-level analysis of the Rheumatoid Arthritis Drugs Market, by end-use.

The Detailed analysis and profiles of additional market players.

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Rheumatoid Arthritis Drugs Market Comprehensive Growth: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2020-2026 KSU | The...

There's no silver bullet to living longer, says Dan Buettner, a National Geographic Fellow and journalist who studies the habits of people living in the "Blue Zones," which are the places in the world where people live the longest. The places are: Okinawa, Japan; Sardinia, Italy; Nicoya, Costa Rica; Ikaria, Greece, and Loma Linda, California.

But making small changes to your everyday routine from how you spend your lunch hour to whether you keep in touch with friends can make a big difference in the long run, Buettner tells CNBC Make It.

Especially during the Covid pandemic, as most people's lives have been dramatically changed, here are the top three habits from the Blue Zones that Buettner says are important to start now.

Famous research from Harvard has shown that people who have close relationships live longer than those who are isolated.

"If you're socially disconnected, [or] if you don't have three friends you can count on on a bad day, it shaves about eight years off your life expectancy, compared to somebody who's well connected," Buettner says.

During the pandemic, even video calls can have a positive effect: "If the conversation has emotional content to it, it counts," he says.

"In the pre-Covid days, we would take a lunch break and often go eat with a colleague," he says. Since that's not possible for many people during the pandemic, he suggests a mid-day video call with someone you care about. "Make that part of your daily routine," he says.

Lots of research supports that exercising wards off your risk of disease and death, but you don't need an exercise bike or home gym to reap the benefits.

"People in Blue Zones walk every day and they make it to 100 without all the other gadgetry and pageantry of working out," Buettner says.

People who commute to work and have to walk to a bus or train station have a lower risk of developing cardiovascular issues. If you're working remotely and are more sedentary than usual, take walks around the block that mimic your morning and evening commutes, Buettner says. Leave your sneakers or walking shoes by the front door "to constantly remind you to use them," he says.

Going on walks during the pandemic is an easy way to exercise safely outdoors and also to socialize with someone from outside of your household. Dr. Anthony Fauci has said he powerwalks 3.5 miles a day to de-stress after work.

Studies have shown that walking boosts your creativity, improves your memory and even helps you sleep.

Taking short mid-afternoon naps is common in many of the Blue Zones regions, Buettner says.

"People who report napping at least 20 minutes, five days a week, have about a third lower rate of heart disease than people who just motor through the day," he says.

After a nap, you typically feel sharper and have lower levels of the stress hormone cortisol, Buettner says. Over time, regular nappers also have less inflammation in their bodies, he adds. (Chronic inflammation is associated with several diseases.)

The key to avoiding grogginess is to only nap for 20 minutes, according to the National Sleep Foundation.If you're working from home, squeeze in a power nap during your lunch break it could improve your performance. Studies suggest that short power naps can increase job performance by up to 34% and improve alertness by 54%.

Check out:How the pandemic killed your motivation, and 6 simple ways to get it back, according to science

Don't miss: The best credit cards for building credit of 2021

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3 easy habits of the worlds longest-living people that can keep you happy and healthy during the pandemic - CNBC

On Thursday, the French nun Sister Andr turned 117 and celebrated with an exceptional feast. A first course of foie gras set the tone for capon with fragrant mushrooms, and was washed down with a hearty glass of red wine.

David Tavella, the communications manager for Andrs care home in Toulon, told the Associated Press that red wine is one of Andrs secrets to longevity. Across the table, red wine, Champagne, and port flowed as Andrs friends toasted in her honor.

The meal concluded a few hours later with Sister Andrs favorite dessert, Baked Alaska. It followed a mass in her honor, led by the local Catholic bishop, and a video call with her great, and great-great, nephews.

At this point, Sister Andr is in line to become the worlds oldest living person. Shes currently Europes oldest and the worlds second oldest, right behind Kane Tanaka, who turned 118 last January.

When asked how shell celebrate her next birthday, Andr replied, I wont be here next year. But dont be perturbed, shes repeated the phrase every birthday for the last ten years, so winemakers better start setting aside their best reds for the next feast.

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117 Year Old French Nun Links Red Wine to Her Longevity - VinePair

When it comes to living a long and healthy life, so much emphasis is put on ones diet. Another factor which can contribute positively to an increased lifespan includes owning a dog. From improving mental health to helping with cardiovascular health, being a dog owner could help boost your longevity. How?

Owning a dog and taking it out for daily walks, acts as a social catalyst for a person.

It helps to promote social connections, conversations and can lead to the development of networks of support.

The connectivity of pets helps a person also feel safer and more loved in their own home.

Owning a dog and getting outdoors more often becomes common practice.

A wealth of research indicates that escaping to a neighbourhood park can lower a person's stress levels, decrease blood pressure and reducetherisk of asthma, allergies, diabetes and cardiovascular disease, whileboostingmental health and increasinglife expectancy.

In another study published in the journal Scientific Reports, spending at least 120 minutes outdoors each week can have a major positive effect on life expectancy and overall health.

The study examined data from nearly 20,000 people in Englandfrom 2014 to 2016, which asked them to record their activities within the past week.

It found that people who spent two hours a week or more outdoors reported being in better health and having a greater sense of well-being than people who didnt get out at all.

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How to live longer: A dog helps improve heart health & manages stress to boost longevity - Express

Virtual Tasting with Phil Long of Longevity Wines Categories: Culture and Heritage, Beer, Wine, & Spirits Visit Their Website Pricing info: $30

Ticket Info: https://thewinefeed.com/products/virtual-tasting-with-phil-long-of-longevity-wines

We are thrilled to share two of his wines with you as well as a Q&A session hosted by Angela Thorpe and Taryn Scarborough.

Angela Thorpe works as a public historian by day, amplifying stories around Black history and culture across North Carolina. By night, she is an emerging wine educator with a passion for exploring and sharing how Black people have contributed to the U.S. wine industry over time. She earned her WSET Level 1 in 2020. Her favorite wine is Spanish Tempranillo.

Taryn Scarborough is a Raleigh, NC native who earned her WSET Level 1 in 2019. She has a passion for educating and sharing her joy of wine with others. Taryn works as a project manager in the clinical research industry and loves to travel (pre-COVID) in her spare time. Favorite wine varietal: Sauvignon Blanc

This event is virtual and will be conducted live over Zoom as well as recorded so that participants may revisit the event. Each signup includes 2 full bottles of wine. We hope you will join us!

2019 Longevity - Chardonnay

2018 Longevity - Cabernet Sauvignon

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Virtual Tasting with Phil Long of Longevity Wines :: Shopping & Retail in North Carolina :: Out and About at WRAL.com - WRAL.com

Winda Wilson celebrated her milestone birthday with a spa day at her senior living facility.

HOUSTON This week Wilda Wilson got a surprise for the ages.

On her 105th birthday, she received a surprise spa day.

Ms. Wilda is an inspiration to all of us," said Abraham Mathew, executive director ofParkway Place.

Wilson's family says Wilda is a doer.

She's been getting things done since 1916. That's when she was born on a farm in Kansas. At that time in history, a brand new Model-T cost a whopping $306 and it was only 22 cents a gallon to fill up.

And if you didn't know, the hamburger bun was invented that year.

A lot has changed over the years.

For decades Wilda was a hairdresser and salon owner. But on this special day, Wilson would be the one in the chair being pampered, getting a scalp massage, styling and a manicure.

"Im glad we could bring a smile to her face today, said Mathew.

Masks were the must-have accessory for Wilson's party, but it didn't cover anyone's happiness. Especially not Wilda's on her big day.

Wilson credits her daily breakfast of five extra crispy pieces of bacon and two pieces of toast smothered in jam to her long life.

Originally posted here:
'An inspiration to all of us': Houston woman turns 105, credits bacon and toast to her longevity - KHOU.com

SportFootballHibsDarren McGregor has long since passed the accepted expiration date on a football career.

Saturday, 13th February 2021, 7:00 am

But, having decided to spice things up, the 35 year-old has proved himself unwilling to be constrained by such arbitrary limitations.

The Hibs defender has had to bide his time this season, regularly restricted to one of the substitute slots as others made the starting berths their own. He managed a few League Cup games as those ahead of him in the pecking order were called away on international duty, but it is only in recent weeks that he has been given the chance to impress on league duty. He has not squandered the opportunity.

He lists several factors but, possibly surprisingly, focuses on the medicinal benefits of turmeric.

It was specifically under Neil Lennon and my knee was giving me all sorts of bother. It was a dull ache and Id tried taking injections or spending a day in and a day out. I dont take any anti-inflammatories but I was advised to take turmeric by the sports science team. Its proven to help with inflammation in your joints. I take them in concentrated form like a tablet and Nathan Ring [physio and Hibs Head of Sports Medicine] has devised a plan along with Colin Clancy, the strength and conditioning coach, which has helped me.

This has maybe been 12-18 months of meticulous work in the background. Trying things and if they dont work trying something else. Now I feel amazing, Im in a sweet spot and I would just like to keep it going.

But, as well addressing his physical predicament, as a team player and mentor, he has also had to consider the bigger picture as he waited to break back into the side.

You have to park your ego and accept that the guys who are playing ahead of you deserve to be in the team. The back three before I came in were doing tremendous and I had to wait for my time.

The gaffer decided to put me in and I think I have taken the opportunity but that is because of a lot of hard work that has been done in the background when no-one was really paying attention. That was in the off chance that I would get an opportunity and I think that has helped me to fit in seamlessly.

The endeavours behind the scenes comprise more than just time on the training pitch or in the gym, it is a lifestyle choice and a willingness to embrace any ideas that could squeeze a bit more out of a body he acknowledges is not getting any younger but remains capable of facilitating his playing ambitions.

Coming into the team for the Rangers game that commanding performance at the heart of the backline, helped the team regain its footing after the Betfred Cup semi-final slip. Retaining his place, he has been part of a winning team ever since.

The Leith side had been heading to Ross County in search of a fourth successive win before a frozen pitch saw that match postponed.

But last weeks important victory over Aberdeen means that they will hold onto third place regardless of results elsewhere. And McGregors strong defensive displays and leadership qualities have contributed to that.

But he admits it wasnt so long ago that he feared time was running out for him and while he concedes that he now treats every game as though it could be his last, he says the turmeric has given him a new lease of life.

You are aware that the clock is ticking and your career is winding down but I can only speak for my own personal feelings and how my body feels. There were times in seasons gone by when i was training some days and not training others just so my body could recover but, this season, touch wood, I have trained every single day and done everything asked of me in the gym.

I just need to keep doing what I'm doing every day and see how long I can go.

As a football player growing up I think you think of 30 as this dreaded age but I think it is definitely changing. Paul Hanlon is 31 now; Paul McGinn is 30.

That gives a combined age of 96 for a back three who have managed two clean sheets in the past three games.

Now, 30 is young. People that dont play the game that are the same age as me, who I maybe went to school with and havent looked after themselves the way I have or done the training Ive done, they maybe put themselves in my shoes and think that at 35 Im definitely past it. But people forget the amount of work we do when we come in here and how meticulous we are with diet etc.

Footballers are definitely getting fitter. Maybe 30-40 years ago, 30 was the age of retirement but I can only be honest. I am training every day and Im sure a lot of the guys will say I do well in training, although some might say I just kick people, and I feel good coming in every day. I still enjoy it.

I'm not at a point when I get up every morning and my body is that sore that I'm thinking I can't be bothered going in. I am appreciating that I am in a hugely privileged position and I want to stay in this position for as long as I can so I am willing to sacrifice whatever needs to be sacrificed for me to keep it going and keep playing for Hibs.

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Hibs defender Darren McGregor reveals the surprising secret behind his longevity and explains why he is not ready to fade into retirement - The...

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PARIS Question: How does one cram enough candles onto a birthday cake for one of the world's oldest survivors of COVID-19? Answer: With 117 candles, you can't.

A French nun who is believed to be the world's second-oldest person celebrated her 117th birthday in style on Thursday, with multiple treats and well-wishes, cards and flowers to fete her exceptional longevity through two world wars and a recent coronavirus infection.

Sister Andr also got a Mass in her honor and a feast with Champagne, red wine and port. Then came a nap followed by more festivities, including an afternoon snack of baked Alaska, her favorite dessert.

"It made me very, very, very, very happy," the birthday girl said. "Because I met all those I love and I thank the heavens for giving them to me. I thank God for the trouble they went to."

Sister Andr's big day got rolling with a morning video call with her great-nephews and great-great nephews, followed by a Mass in her honor led by the local Catholic bishop, said David Tavella, the communications manager for the care home in the southern French city of Toulon where the nun lives.

Her birthday feast included a starter of foie gras, followed by capon with fragrant mushrooms. "All of it washed down with red wine, because she drinks red wine. It's one of her secrets of longevity," Tavella told The Associated Press. There was also port and Champagne "because 117 years have to be toasted," he said.

She skipped dessert because she was tired, but got it served to her later after a nap with three candles and the numerals 117 on top.

Packing on 117 candles would have been impossible.

"We stopped trying a long time ago," Tavella said. "Even if we made big cakes, I'm not sure that she would have enough breath to blow them all out. You would need a fire extinguisher."

Sister Andr's birth name is Lucile Randon. The Gerontology Research Group, which validates details of people thought to be 110 or older, lists her as the second-oldest known living person in the world, behind only an 118-year-old woman in Japan, Kane Tanaka.

Tavella told French media earlier this week that Sister Andr tested positive for the coronavirus in mid-January but she had so few symptoms that she didn't even realize she was infected. Her survival made headlines both in France and beyond.

"When the whole world suddenly started talking about this story, I understood that Sister Andr was a bit like an Olympic flame on a 'round the world tour that people want to grab hold of, because we all need a bit of hope at the moment," Tavella said.

When Tavella talked to her Thursday about celebrating her next birthday in 2022, she replied: "I won't be here next year," he quoted her as saying, adding: "But she has been saying that for 10 years."

By strange coincidence, Tavella celebrated his 43rd birthday on Thursday.

"We often joke that she and I were born on the same day," he said. "I never tell myself that she is 117 because she is so easy to talk to, regardless of age. It is only when she talks about World War I as though she lived through it that I realize, 'Yes, she did live through it!'"

Originally posted here:
COVID-defying nun toasts 117th birthday with wine and prayer - The Topeka Capital-Journal

Global Longevity and Anti-senescence Therapy Market Trends and Forecast

The global longevity and anti-senescence therapies market should grow from $329.8 million in 2018 to $644.4 million by 2023 with a compound annual growth rate (CAGR) of 14.3% during 2018-2023.

Report Scope:

The scope of this report is broad and covers various therapies currently under trials in the global longevity and anti-senescence therapy market. The market estimation has been performed with consideration for revenue generation in the forecast years 2018-2023 after the expected availability of products in the market by 2023.

The global longevity and anti-senescence therapy market has been segmented by the following therapies: Senolytic drug therapy, Gene therapy, Immunotherapy and Other therapies which includes stem cell-based therapies,.

Revenue forecasts from 2028 to 2023 are given for each therapy and application, with estimated values derived from the expected revenue generation in the first year of launch.

The report also includes a discussion of the major players performing research or the potential players across each regional longevity and anti-senescence therapy market. Further, it explains the major drivers and regional dynamics of the global longevity and anti-senescence therapy market and current trends within the industry.

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The report concludes with a special focus on the vendor landscape and includes detailed profiles of the major vendors and potential entrants in the global longevity and anti-senescence therapy market.

- 71 data tables and 40 additional tables- An overview of the global longevity and anti-senescence therapy market- Analyses of global market trends, with data from 2017 and 2018, and projections of compound annual growth rates (CAGRs) through 2023- Country specific data and analysis for the United States, Canada, Japan, China, India, U.K., France, Germany, Spain, Australia, Middle East and Africa- Detailed description of various anti-senescence therapies, such as senolytic drug therapy, gene therapy, immunotherapy and other stem cell therapies, and their influence in slowing down aging or reverse aging process- Coverage of various therapeutic drugs, devices and technologies and information on compounds used for the development of anti-ageing therapeutics- A look at the clinical trials and expected launch of anti-senescence products- Detailed profiles of the market leading companies and potential entrants in the global longevity and anti-senescence therapy market, including AgeX Therapeutics, CohBar Inc., PowerVision Inc., T.A. Sciences and Unity Biotechnology

Summary

Global longevity and anti-senescence therapy market deals in the adoption of different therapies and treatment options used to extend human longevity and lifespan. Human longevity is typically used to describe the length of an individuals lifetime and is sometimes used as a synonym for life expectancy in the demography.

Anti-senescence is the process by which cells stop dividing irreversibly and enter a stage of permanent growth arrest, eliminating cell death. Anti-senescence therapy is used in the treatment of senescence induced through unrepaired DNA damage or other cellular stresses.

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Global longevity and anti-senescence market will witness rapid growth over the forecast period (2018-2023) owing to an increasing emphasis on Stem Cell Research and an increasing demand for cell-based assays in research and development.

An increasing geriatric population across the globe and a rising awareness of antiaging products among generation Y and later generations are the major factors expected to promote the growth of global longevity and anti-senescence market. Factors such as a surging level of disposable income and increasing advancements in anti-senescence technologies are also providing traction to the global longevity and anti-senescence market growth over the forecast period (2018-2023).

According to the National Institutes of Health (NIH), the total geriatric population across the globe in 2016 was over REDACTED. By 2022, the global geriatric population (65 years and above) is anticipated to reach over REDACTED.

An increasing geriatric population across the globe will generate huge growth prospectus to the market.

Senolytics, placenta stem cells and blood transfusions are some of the hot technologies picking up pace in the longevity and anti-anti-senescence market. Companies and start-ups across the globe such as Unity Biotechnology, Human Longevity Inc., Calico Life Sciences, Acorda Therapeutics,.

are working extensively in this field for the extension of human longevity by focusing on study of genomics, microbiome, bioinformatics and stem cell therapies,. These factors are poised to drive market growth over the forecast period.

Global longevity and anti-senescence market is projected to rise at a CAGR of REDACTED during the forecast period of 2018 through 2023. In 2023, total revenues are expected to reach REDACTED, registering REDACTED in growth from REDACTED in 2018.

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The report provides analysis based on each market segment including therapies and application. The therapies segment is further sub-segmented into Senolytic drug therapy, Gene therapy, Immunotherapy and Others.

Senolytic drug therapy held the largest market revenue share of REDACTED in 2017. By 2023, total revenue from senolytic drug therapy is expected to reach REDACTED.

Gene therapy segment is estimated to rise at the highest CAGR of REDACTED till 2023. The fastest growth of the gene therapy segment is due to the Large investments in genomics.

For Instance; The National Human Genome Research Institute (U.S.) had a budget grant of REDACTED for REDACTED research projects in 2015, thus increasing funding to REDACTED for approximately REDACTED projects in 2016.

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Global Longevity and Anti-senescence Therapy Market Trends and Forecast interpreted by a new report - WhaTech

Former India batsman, VVS Laxman reveals that he was impressed by Ishant Sharmas will to bowl long spells when he first met the pacer. Laxman lavishes praises on the hard work the Ishant has done since making his debut in 2007 to pick 300 Test match wickets.

On Monday, in Chennai, against England with the wicket of Dan Lawrence, Ishant became the 6th Indian bowler and only the third Indian pacer after Kapil Dev and Zaheer Khan to bag 300 Test wickets.

The lanky seamer has had a career marred with injuries, however, illustrious with some scintillating spells over the years as he reached this feat in his 98th Test. It is often talked about how captains, in domestic cricket and for the national team, have a liking for Ishant because of his endurance to bowl longer spells.

When I was tweeting about his 300th wicket, I remembered the debut Test match of Ishant in 2007 against Bangladesh. A tall, lanky fast-bowler. We all knew he had the talent to do well for India. But the amount of hard work he exhibited throughout his career.

There was Zaheer and other talented fast bowlers like RP Singh, Sreesanth, or Irfan Pathan, but here was one fast bowler who was ready and prepared to bowl 20 overs every day not every innings but every day. Theres a reason why he has had this longevity, VVS Laxman told Star Sports.

VVS Laxman observed that Ishant has a better wrist position and is bowling more fuller lengths than he used to prior to the time spend with former Australia pacer, Jason Gillespie. After remaining unsold in the IPL auction, Ishant went to England to play county cricket for Sussex in 2018 where he was coached by Gillespie.

VVS Laxman reckons the senior India pacer returned a much better and improved bowler from his stint in the county. And rightly so; since the start of 2018, he has picked 74 wickets in 19 Tests at an average of 19.39; compared to the average of 36.55 in his previous 79 Tests.

What changed since 2018, is his wrist position. He is a very hard-working bowler, always looking to improve. He went to Sussex, worked with Jason Gillespie, played in the country championship, and was working on his seam position. And this is what he got right. Since then, he is pitching the ball up and he is ending up getting more wickets, Laxman added.

Also Read: Had Kuldeep Yadav Played For Some Other Country, He Would Have Taken 200 Wickets And Played 50 Tests By Now, Says His Coach Kapil Pandey

Link:
Ishant Sharma Was Prepared To Bowl 20 Overs A Day, That's The Reason For His Longevity - VVS Laxman - Cricket Addictor

Jack and Rose, Allie and Noah, Johnny and Baby, Sandy and Danny these are just some of the most iconic movie couples that spring to mind when we think of L-O-V-E.

For us romantics, its a brief snapshot of a couples unwavering passion for each other that we can escape in for an hour or two (whether thats proving their love by building a house, ensuring nobody puts their beloved in the corner, or letting the other hog the door so they could survive a treacherous icy ocean).

But heres the thing; theres more to relationships than the honeymoon period. And none of our favourite romantic films ever seem to show those uneventful days that come later. You know, like the ones weve endured ourselves in lockdown purgatory, as we constantly ask our partner how their day was, despite fully knowing that it was, quite literally, the same as yesterday.

But no matter how unrealistic we know it is, we cant help but fall back on those same tried-and-tested romcoms.

They play to our longings and desires for connection, says psychologist, author and founder of The Village, Dr Kalanit Ben-Ari.

They are also something we can all relate to so many people are in love with the idea of a romantic relationship. When we are touched by a scenario in a film, we are actually in touch with a part in ourselves. It could be our dreams and longing or fears and losses, which might be in our awareness or unconsciously.

Hoping for a happily ever after certainly isnt a bad thing, but I know my own favourite on-screen couples have skewed my own expectations of love and not exactly in a healthy way.

Im not alone in this, either; as Dr Ben-Ari says: Even though a film can generate feelings of positivity, some might experience an after-effect depending on whats going on in their own life.

For example, a couple at the start of a relationship might be left feeling incredibly positive, whereas couples in an uncertain stage of their relationship might feel a sense of longing and sadness for the disparity between the films story and their reality.

Working closely with Dr Ben-Ari, then, I decided to take a look back at some of those iconic Hollywood couples who many perceive to be epic examples of love.

Some definitely stand the test of time. Others, on closer inspection, have some issues.

Jack and Rose, Titanic

Those of us who have seen Titanic enough times will argue there was space for Jack on that floating door. Which means he sacrificed himself unnecessarily for a holiday romance that had lasted just two days.

Thats right; from the very moment that Jack saved Rose from jumping off the Titanic to the moment he freezes in the Atlantic Ocean, only a little over 48 hours has passed. Anyone else think it was already over for Rose?

Longevity rating: 1/5

Johnny and Baby, Dirty Dancing

Johnny and Baby are from different walks of life who find themselves in the same place at the right time in Dirty Dancing. But, with a considerable age gap between them (and not much in common other than their dancing skills), its likely this love was never built to last outside of Kellermans.

Longevity rating: 2/5

Sandy and Danny, Grease

Shes the ultimate good girl, and hes the bad boy who just wants to get friendly down in the sand. Essentially, Sandy and Danny are complete polar opposites who spend the entire film trying to awkwardly impress each other and their peers.

These typical narratives often carry a deeper meaning to what we see on the surface, says Dr Ben-Ari.

There are unconscious processes or agendas that cause opposites to attract for example, and those who are being pursued might not show any interest as a form of defence mechanism from past pain.

Longevity rating: 2/5

Annette and Sebastian, Cruel Intentions

Yes, its another good girl/bad boy trope.

In Cruel Intentions, Sebastian makes a bet with his scheming stepsister Katherine and winds up falling truly in love with his pure-as-a-dove prey, Annette. When his toxic masculinity finally gives way to vulnerability, though, its too late and we wind up speeding towards the films tragic conclusion.

Longevity rating: 2/5

Josh and Cher, Clueless

Clueless is a full-on Monet: it all looks great from far away but up close-up its a mess. Personally, I swoon over any film with the ageless Paul Rudd, but when Chers true love ends up being his character her eye-rolling, nit-picking stepbrother, Josh it really is a case of as if!

Longevity rating: 2/5

Allie and Noah, The Notebook

Communication is a big deal in a relationship; if you dont tell the other what youre thinking or how youre feeling, then how on earth are they supposed to know?

Noah and Allies short-lived summer romance (which begins, as youll no doubt remember, with him blackmailing her into dating him) is heartbreakingly dragged out through the course of their entire lives, and all because neither of them could be bothered to sit down and have a proper conversation.

Longevity rating: 3/5

Lara Jean and PeterKavinsky, To All the Boys Ive Loved Before

Shes the sweet outsider, hes the cute popular jock: its a familiar story. Unlike Grease and The Notebook, though, these two dont just take the time to get to know one another; they make sure they share the same core moral values, too.

Better still? Even in these modern social media times, its an adorable love letter from Lara Jean to Peter Kavinsky that brings them together. Perfection.

Longevity rating: 4/5

Rosemary and Dill, Easy A

Stanley Tucci and Patricia Clarkson play parents Rosemary and Dill in the classic 2010 film Easy A. They are, quite literally, the backbone of this delightful tale, and they show that mature love can be fun, caring and passionate even while dealing with their daughter Olives slut-shaming drama.

Longevity rating: 5/5

Monica and Quincy, Love And Basketball

Love And Basketball is a cult classic, with childhood sweethearts Monica and Quincy sharing an everlasting bond over the sport. A friendship turns into real love. And, yes, they make some mistakes along the way before finding the right time to be together.

But, as director Gina Prince-Bythewood explains to Shadow And Act about the films iconic sex scene, the whole thing is hinged on the couplds respect for one another.

When we did it, I was very specific about what I wanted it to be, she said. Its a girls first time, Monicas first time, I wanted it to be the fantasyI kind of wanted to give a blueprint for boys and girls of what to expect. I wanted the reality of it. Sanaa [Lathan] and Omar [Epps] were so dope in that scene, so protective of each other. They just gave the realness, especially just the looks that they were giving each other that said so much, which added organic humor to it which I loved.

Lets just ignore that he was two weeks away from the wedding when Monica finally made her move, yeah?

Longevity rating: 4/5

Jim and Michelle, American Pie

Jim loses his virginity to Michelle after prom. She isnt the porn star of his dreams, but shes quirky, and human, and believable. And, while they may seem mismatched, theyre destined to make it down the altar. Band geek and goofball for the win!

Longevity rating: 5/5

Sarah and Derek, Save The Last Dance

When white ballet dancer Sarah ends up at a majority-Black high school, she meets Derek. The interracial couple go against the grain, much to the distaste of his friends and family, but cringeworthy hip hop dancing scenes aside (Lets put that S-E-X in those H-I-P-S) they support each others dreams 100% and find love together.

Longevity rating: 4/5

Erin and Garrett, Going The Distance

This film made me believe that, if you really love someone, you will spend hours talking on the phone to keep that long distance relationship going. Im here, fresh from heartbreak, to tell you that isnt the case. Going The Distance deals with the idea that you cant physically touch someone else for months on end. And, while Erin and Garrett nearly dont make it, after a time jump, a sensible cooling-off period, and a decision to relocate, true love wins.

Longevity rating: 4.5/5

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Best film couples & movie relationships, according to a therapist - Stylist Magazine

YORBA LINDA, Calif., Feb. 8, 2021 /PRNewswire/ -- Dental professionals have long sought improvements in dental implant bridge stability, longevity, and esthetics. NobelProcera Zirconia Implant Bridge is a premium solution that provides individualized, high-end, implant-based restorations and services that seek to improve patient outcomes, esthetics, and implant longevity.

"Precision is a key feature for positive patient outcomes and implant longevity. The NobelProcera Zirconia Implant Bridge is cement-free, manufactured with high-strength material and is an excellent choice," said Prof. Dr. Markus B. Blatz from Philadelphia, Pennsylvania.

Made for estheticsAvailable in 10 precisely matched VITA shades, the NobelProcera Zirconia Implant Bridge is designed with esthetics in mind. It was designed for a smaller, angulated screw channel, with the new Omnigrip Mini Screwdriver to improve occlusal esthetics.

With the recent partnership with DOCERAM Medical Ceramics, the zirconia implant bridges are produced with the high-end Nacera Pearl zirconia material, which meets Nobel Biocare's highest quality standards.

Complete design flexibilityThe new offering is available in full-contour, cut-back, thimble, and framework styles (with or without soft tissue), making it possible to achieve natural looking restorations. The combination of the angulated multi-unit abutment and angulated screw channel provides up to 55 degrees of restorative freedom.

Cement-freeRemoving cement from the equation saves time and simplifies the process of implant bridge procedures.

High precision and material strengthNobelProcera works to achieve the goals of improved stability, durability, and esthetics through a manufacturing process that prioritizes high material strength and superior precision.

NobelProcera Zirconia Implant Bridge is now available in DTX Studio Lab and 3Shape systems.

_________________________Nobel Biocare is a world leader in the field of innovative implant-based dental restorations. The company's portfolio offers solutions from single tooth to fully edentulous indications with dental implant systems (including key brands NobelActive and NobelParallel), a comprehensive range of high-precision individualized prosthetics and CAD/CAM systems (NobelProcera), digital solutions for treatment planning (DTX Studio suite) and guided surgery, as well as biomaterials (creos regenerative solutions). Nobel Biocare supports its customers through all phases of professional development, offering world-class training and education along with practice support and patient information materials.

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SOURCE Nobel Biocare Usa, Inc.

Company Codes: Swiss:NOBN

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The new NobelProcera Zirconia Implant Bridge simplifies the partnership between clinicians and technicians - BioSpace