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Archive for August, 2021

Human tissues to be grown in microgravity conditions aboard the ISS – E&T Magazine

Monday, August 30th, 2021

Experiments to see how human tissue will grow in zero-gravity conditions are to be conducted onboard the International Space Station (ISS).

Researchers at Airbus and the University of Zurich (UZH) plan to send materials up with the next supply flight for the ISS that will enable astronauts to grow three-dimensional organ-like tissues called organoids.

The organoids, which will be grown from human adult stem cells, cannot be produced on Earth because they require supporting skeletons due to the effect of gravity.

3D organoids are of great interest to pharmaceutical companies because they could allow drugs to be tested directly on human tissue which could produce more reliable results and eliminate the need for animal models.

Organoids grown from patient stem cells could also be used in the future as building blocks for tissue replacement therapy for damaged organs. Globally, the number of donated organs is far from sufficient to meet demand.

Initial preparatory tests on the ISS 18 months ago were successful. In this experiment, 250 test tubes containing human stem cells that spent a month on board the space station showed differentiated organ-like liver, bone and cartilage structures that developed as intended from the tissue stem cells.

In contrast, the cultures created on Earth, which were grown as controls under normal gravity conditions, showed no or only minimal cell differentiation.

In the current mission, tissue stem cells from two women and two men of different ages are being sent into space.

The researchers are testing how robust the method is when using cells of different biological variability. They expect production to be easier and more reliable in microgravity than using support structures to grow on Earth.

Currently, the focus is on production engineering issues and quality control, said UZH scientist Oliver Ulrich.

With regard to the envisaged commercialisation, we now have to find out how long and in what quality we can keep the organoids grown in space in culture after their return to Earth.

Airbus project manager Julian Raatschen said: If successful, the technology can be further developed and brought to operational maturity. Airbus and the UZH Space Hub can thus make a further contribution to improving the quality of life on Earth through space-based solutions.

The sample material will return to Earth at the beginning of October with the first results expected from November.

In June, an additional solar array was deployed on the ISS to give the station a much needed electricity boost as demand for low-gravity experiments and space tourism grows.

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Is rheumatoid arthritis a disability? Benefits and more – Medical News Today

Monday, August 30th, 2021

Rheumatoid arthritis is a chronic condition in which the bodys immune system attacks its own tissues. The condition typically causes swelling, stiffness, and pain in the joints. However, it may also affect other areas of the body, including the cardiovascular system, kidneys, skin, and eyes.

For some, rheumatoid arthritis (RA) symptoms can significantly affect their ability to carry out day-to-day tasks. In these situations, the person may qualify for disability benefits.

This article discusses when RA is a disability, how to know if a person living with RA qualifies for benefits, and how to claim them. We also provide tips on how to manage the symptoms of RA.

RA is a progressive condition, meaning that it will worsen over time. The pace at which the disease progresses will depend on multiple factors, including:

In a 2008 study of RA and work disability in the United States, 35% of people stopped working within 10 years of their initial RA diagnosis.

According to the Global Healthy Living Foundation, to qualify for disability benefits, a person would need to show that they are unable to work for a year or that working may result in death.

The Social Security Administration (SSA) considers RA a disability if a person meets the following eligibility criteria:

The SSA calculates work credits based on the total amount a person earns each year. According to the SSA, in 2021, a person can receive one credit for every $1,470 of earned income for a maximum of four credits per year.

Though the amount needed per credit often increases each year, a person can accumulate credits at different points in their life. They will not disappear if a person stops working for several years.

Disability benefits, more commonly known as Social Security Disability Income (SSDI), are available for qualified individuals. To qualify, a person must have worked and paid into social security for a number of years.

The SSA outlines the number of years a person needs to have worked to qualify for SSDI. The number of years varies based on the age of the person. According to the SSA, people 3142 years old need to have earned 20 credits in the 5 years before becoming disabled.

However, a person aged 62 years or older needs to have earned 40 credits in the 10 years before becoming disabled.

According to the SSAs monthly statistical snapshot, the average monthly benefit in June 2021 for people under 65 years old with a disability was $1,310.

The SSA classifies RA under inflammatory arthritis.

According to the SSA, to qualify for SSDI, a person living with RA needs to meet one or more of the following criteria:

In determining benefits, the SSA will also look at a persons ability to sustain work based on their Social Securitys Medical-Vocational Guidelines.

The guidelines use the Residual Functional Capacity (RFC) to determine how much work a person living with RA can reasonably carry out. The RFC classification outlines four broad categories based on the physical demands of a persons work. They include:

If a person cannot complete their expected work based on their disability and experience level, they may qualify for full benefits. However, a person who can complete light or sedentary work may not be eligible if they can work in a sedentary position.

The RFC also takes into account the following factors to determine if a person should receive SSDI:

People may apply for SSDI benefits online here or by calling 800-772-1213.

The SSA provides an Adult Disability Checklist to help people determine what they need before applying for disability benefits. They provide one checklist for completing an application online and another for completing an application over the phone.

The checklist details the documents and information a person needs to apply for benefits. Some of the information a person will need includes:

There is no cure for RA, but there are ways to manage its symptoms and slow its progression. The goal of most treatment plans is to:

Some standard treatment options include:

A person should talk to their doctor if they notice worsening or continued symptoms. Working closely with a doctor is important for managing symptoms and reducing the severity of RA.

RA is a chronic disease that primarily affects the joints but can also affect other parts of the body. The condition can progress to the point that a person finds it difficult or impossible to maintain their occupation.

The SSA classifies RA as a type of inflammatory arthritis. A person with RA may qualify for benefits if they become unable to work. A person must document that they meet the Social Security criteria for disability before receiving any benefits.

Although there is no cure for RA, a person can manage the condition with medications, therapies, and appropriate lifestyle changes.

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Is rheumatoid arthritis a disability? Benefits and more - Medical News Today

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Pandemic surge causes major shortage of a drug that treats rheumatoid arthritis and severe Covid-19 – CNN

Monday, August 30th, 2021

The Virginia woman says she and her whole family got the vaccine as soon as it was available. She's immunocompromised and susceptible to getting really sick if she caught Covid-19. She has lupus and rheumatoid arthritis and it is these diseases that add an extra layer to her frustration and anger.

"We did our part to preserve ourselves, our community, in trying to help battle this by getting vaccinated," Melendez said. "It's just unfortunate that the ignorance and laziness, for lack of better words, of other people who avoided taking the vaccine and ended up in the hospital with Covid, now has to impact me."

The antibody treatment blocks an inflammatory protein called IL-6 that causes damage in rheumatoid arthritis. That same protein plays a role in some of the serious symptoms in people with severe Covid-19 infections.

In the United States, supplies of several dose levels of this medicine have been out of stock since last Monday.

A life saver and life changer

For patients with Covid-19, the drug can be lifesaving. For patients with rheumatoid arthritis, like Melendez, it can be life-altering.

"It has restored my ability to have a fully functioning life," Melendez said. "Before it, it was so bad that simple things like brushing my teeth, combing my hair, opening a bottle of water, unfastening a pair of jeans, going to a restaurant, feeding myself were all challenges. Standing up and walking was hard. That's how bad my RA gets and I'm only 47."

Without the medication, even for a month, people can suffer debilitating flare-ups.

"It isn't easy to switch drugs, especially when you're on a serious drug like Actemra," Taylor said. "You surely don't want to be bouncing around."

Genetech is expanding manufacturing

On Thursday, Genentech sent a notice to customers saying it was "working as urgently as possible to expedite replenishments and increase manufacturing capacity and supply wherever possible."

The company said the medicine should be available for distribution starting Monday, August 30, but "given continued tight supply, Genentech anticipates additional intermittent periods of stockouts in the months ahead if the pandemic continues at the current pace."

A subcutaneous injectible form of Actemra that has not been authorized to treat Covid-19 is still available for patients with rheumatoid arthritis. Snow suggested patients ask their doctors about it. It's unclear if insurance would cover it.

And for hospitalized Covid-19 patients, there are some alternatives if Actemra is not available.

"We also strongly encourage Roche to facilitate technology transfer and knowledge and data sharing to broaden access to this important treatment," the WHO said in its statement.

More pandemic shortages

"All it takes is a little spike in demand and we have problems," Fox said.

Because of the uncertainty of surges, some facilities also hoarded some medication. Genentech recently said it would not take orders back, and that should cut down on hoarding, Fox said.

"The same as any other manufacturer, they're going to make enough for what they think they need for the year. Nobody wants to have extra inventory sitting around," Ganio said.

Ganio said the American Society of Health System Pharmacists has also heard reports of shortages of in-line filters that are used with IV bags. There's been more demand for them due to the increasing use of the Regeneron antibody cocktail used to treat people with Covid-19.

"It's very frustrating. In shortage after shortage after shortage the manufacturer does not have a plan for when they can't supply product. It's often 'good luck, we're out,' " Fox said. "All decisions are made about the business first and unfortunately, there's no requirement to make anything, no matter how life saving it is."

"I know I can't be the only person who's sitting here today on edge," Melendez said. "I want to make sure they don't forget about us."

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Pandemic surge causes major shortage of a drug that treats rheumatoid arthritis and severe Covid-19 - CNN

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Rheumatoid arthritis and diabetes: Link, prevention, treatment – Medical News Today

Monday, August 30th, 2021

Rheumatoid arthritis (RA) is a type of inflammatory arthritis and autoimmune disorder. People with RA have an increased risk of diabetes, while diabetes can also raise the risk of RA. Excessive inflammation, lifestyle factors, and genetics may be among the factors that connect the two conditions.

RA and diabetes also share several risk factors and causes, including certain medications.

This article discusses the link between RA and diabetes and explains how people can prevent and treat each of these conditions.

Although diabetes and RA share some similarities in terms of their causes and risk factors, they are very different conditions.

RA is an inflammatory autoimmune disease in which the bodys immune system mistakenly attacks healthy cells and tissue. It often causes inflammation in the joints of the hands, knees, or wrists. In some cases, it may affect the lungs, heart, eyes, or other organs throughout the body.

Type 2 diabetes is the most common form of diabetes. In a person living with the condition, the body either does not produce enough insulin or does not use it effectively. In either case, blood sugar levels will elevate.

The most likely connection between type 2 diabetes and RA involves inflammation and a buildup of cytokines known as tumor necrosis factor (TNF) in the body. The Arthritis Foundation notes that TNF plays a necessary role in wound healing by causing an inflammatory effect. However, it can be harmful when too much TNF is circulating in the body.

In RA, the immune systems attack on the joints causes TNF to build up in the body. In type 2 diabetes, fat cells mainly produce TNF, which can cause the body to develop insulin resistance over time. As a result, it is possible that the inflammation and TNF associated with RA could increase the risk of a person developing type 2 diabetes.

Other possible connections between RA and type 2 diabetes involve medications and lifestyle factors that can act as risk factors for both conditions.

Certain medications, such as corticosteroids, can increase the likelihood of developing type 2 diabetes. Also, RA might lead to a person having a more sedentary lifestyle, which is a risk factor for type 2 diabetes.

People living with type 1 diabetes may also be at higher risk of developing RA and vice versa.

The Global Healthy Living Foundation, a nonprofit organization, explains that type 1 diabetes is an autoimmune disorder in which the immune system mistakenly attacks insulin-producing cells. It notes that a person living with one autoimmune disorder has an increased chance of developing a second one at some point in their lifetime.

People living with RA may have an increased risk of developing type 2 diabetes. Researchers have found that people living with RA are 23% more likely to develop type 2 diabetes compared with the general population.

In a 2020 review, researchers noted that RA can negatively affect a persons insulin resistance, which can cause the body to develop more fat. They also reported that many people with RA who develop type 2 diabetes also have other risk factors, including obesity.

People living with RA may be more likely to develop type 1 diabetes, as both conditions are autoimmune disorders. A person who has an autoimmune condition is more likely to develop another one during their lifetime.

The Arthritis Foundation suggests that people over the age of 45 years get screenings for diabetes every 3 years, noting that this is particularly important for those living with RA.

Learn more about risk factors for type 2 diabetes.

People living with type 1 diabetes have a higher risk of developing RA. In part, this may be due to both conditions being autoimmune disorders. There also may be a genetic link between the two conditions research has shown that the gene PTPN22 is linked to both conditions.

Some researchers believe that the inflammation associated with type 2 diabetes triggers RA in people who are genetically predisposed. A 2014 study in Taiwan supports this theory, finding that living with type 2 diabetes increases the risk of RA in females.

It is unclear whether type 1 or 2 diabetes could make RA symptoms worse. However, similar lifestyle changes can help both conditions, including:

Doctors can help create an effective treatment plan for a person living with RA, diabetes, or both.

A doctor can recommend a combination of medications alongside self-care strategies to slow the progression of RA and prevent joint damage. The CDC says that possible strategies for people living with RA include:

Learn some tips for dealing with rheumatoid arthritis flare-ups here.

The Arthritis Foundation notes that treating a person living with RA and type 2 diabetes is not much different than treating a person living with RA alone. One of the most important aspects for a person living with both conditions is to get regular exercise to help prevent heart disease.

A doctor may recommend a combination of medications and lifestyle adjustments to manage diabetes. In some cases, a person may find that diet and exercise modifications are enough to control their blood sugar.

If a person cannot control their blood sugar with diet and exercise alone, a doctor may recommend medication. They may recommend drugs to help the body process sugar or prescribe insulin.

Read a review of therapies and lifestyle changes for diabetes here.

RA and diabetes share some similar features, and a person with one condition may have an increased risk of the other.

People living with type 1 diabetes may have an increased risk of RA, and vice versa, due to the connection between autoimmune disorders and genetics. The inflammation associated with type 2 diabetes may put individuals with this form of diabetes at higher risk of RA. RA can make a person more likely to develop type 2 diabetes by affecting their insulin resistance.

A person living with RA should get regular screenings and watch for warning signs of diabetes. A person with a diagnosis of type 2 diabetes should follow their doctors treatment advice.

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Drug used to treat rheumatoid arthritis and COVID-19 in short supply – KSL.com

Monday, August 30th, 2021

A medication used widely in treating rheumatoid arthritis is out of stock due to a rise in COVID-19 hospitalizations, affecting patients in the U.S. and Utah. (Adam Sotelo, KSL-TV)

SALT LAKE CITY A medication used widely in treating rheumatoid arthritis is out of stock due to a rise in COVID-19 hospitalizations, affecting patients in the U.S. and Utah.

Sharon Greenwood, of Utah County, was diagnosed with rheumatoid arthritis when she was just 12 years old.

"There is no cure," Greenwood said. "Even if (arthritis) gets in your jaw, then eating is a problem because you can't chew."

Decades later and a dozen or so failed treatments, Greenwood finally has a medication that works for her tocilizumab, known by the brand name Actemra. She has been using the treatment for 10 years.

"Without it, the pain is completely debilitating," Greenwood explained.

However, Greenwood says her monthly treatment is now out of reach.

"I went in for my treatment on Wednesday with the hospital," Greenwood said that's when her nurse at Intermountain American Fork Hospital told her there was a major shortage.

"Apparently, just that morning, the drug had been called in. The nurses were told they were not to use it for anyone because it was being confiscated and gathered up to be sent to a central location," Greenwood said.

Greenwood said she was one of the last rheumatoid arthritis patients to get their treatment.

"The nurse apparently had my drug in her hand and the pharmacist said 'No, we have to take that,' and she said 'No, our patient is here waiting for it,'" she said.

#EXCLUSIVE- "There's no guarantee," Hundreds of patients... are out of crucial treatment for rheumatoid arthritis, Actemra. @genentech says surge in #COVID19 hospitalizations is to blame for unsatiable demand...& it's affecting Utahns like Sharon Greenwood. Story now on @KSL5TVpic.twitter.com/CbQz5nPGHI

Greenwood said nurses told her the drug was going to be reserved for COVID-19 and possibly cancer patients as the delta variant fuels a surge in virus cases and hospitalizations.

"They told me they were hoping to have more come in in about 4-6 weeks, which will be around the time I have my next appointment, but there's no guarantee," Greenwood said, explaining that she is worried about the possibility of not getting her next treatment.

On June 24, the FDA issued an emergency use authorization for Actemra to treat COVID-19 patients in hospitals, including adults and kids age 2 and older.

"The EUA is based on results from four randomized, controlled studies that evaluated Actemra for the treatment of COVID-19 in more than 5,500 hospitalized patients. The results of these studies suggest that Actemra may improve outcomes in patients receiving corticosteroids and requiring supplemental oxygen or breathing support," said a company spokesperson for Genentech, the U.S. manufacturer of Actemra.

Genentech is the sole manufacturer and supplier of the drug in the U.S. Its parent company, Roche, manufactures the drug outside of the U.S.

However, despite efforts to ramp up production, Genentech confirmed in a written response to KSL, "they're experiencing a temporary stock out" of the drug in the U.S. since Aug. 16.

A company spokesperson added they expect to receive scheduled replenishments by the end of August. However, they warned, if the pandemic continues to spread at its current pace, there could be more shortages in weeks and months ahead.

"The dramatic emergence of the COVID-19 delta variant, as well as the unexpected slowing of vaccination rates in the U.S., has led to an overwhelmingly high incidence of COVID-19 hospitalizations in certain areas of the country. This new wave of the pandemic has led to Genentech experiencing an unprecedented demand for Actemra IV well-over 400% of pre-COVID levels over the last two weeks alone and it continues to increase," said Lindsey Mathias, senior manager of Genentech corporate relations.

In the meantime, Greenwood said her doctor and nurses told her the drug is being stockpiled and rationed priority is going to COVID-19 patients.

"For me, it's about quality of life. But for them, it's a matter of life or death, and so it does need to go to them first because they are the greater need," Greenwood said.

Nevertheless, Greenwood said the situation underscores the impact of others' choice not to be vaccinated as Intermountain experts have previously stated 90% of hospitalized COVID-19 patients are unvaccinated.

"Unless you suffer from rheumatoid arthritis, you may never know that choosing not to be vaccinated is affecting people like me," Greenwood said, "My hope is that people would choose wisely."

The World Health Organization, in conjunction with UnitAid, released a statement last week calling on the company to ensure equal access to the medicine and look for ways to increase global supplies.

KSL's Garna Mejia is also in contact with Intermountain Healthcare, Greenwood's health care provider, for more information on what exactly the supply shortage looks like in Utah. An update is expected later this week.

The most updated information on the U.S. supply of Actemra can be found here, while information on world supplies can be found here.

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Poverty Tied to Worse Functional Status in Rheumatoid Arthritis – HealthDay News

Monday, August 30th, 2021

TUESDAY, Aug. 24, 2021 (HealthDay News) -- Worse functional status and increased probability of functional decline are seen for patients with rheumatoid arthritis (RA) with lower socioeconomic status (SES), according to a study published online Aug. 4 in JAMA Network Open.

Zara Izadi, M.Pharm., from the University of California in San Francisco, and colleagues examined the association between SES and functional status in patients with RA using data from the American College of Rheumatology's Rheumatology Informatics System for Effectiveness registry. Data were included for 83,965 patients with a confirmed RA diagnosis who were seen at participating rheumatology practices.

The researchers found that the mean functional status score was worse at lower SES levels for all measures (e.g., Multidimensional Health Assessment Questionnaire quintile 1 and 5: 1.79 and 2.43, respectively). The probability of functional decline was 14.1 and 18.9 percent in the highest and lowest SES quintile, respectively, in longitudinal analyses. Disease activity partially mediated the association between SES and functional decline (7 percent).

"We found important disparities in functional status by SES in a national cohort of individuals with RA, despite utilization of rheumatology care," the authors write. "Future qualitative research is important to further our understanding of factors that affect functional status, including factors outside of medical care that can be intervened on."

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text

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Mississippi hospitals dealing with global shortage of arthritis drug tocilizumab used to treat severely ill COVID-19 patients Mississippi hospitals…

Monday, August 30th, 2021

COLUMBUS, Miss. (WCBI) As hospitals across Mississippi and around the country continue to deal with high numbers of COVID-19 patients, yet another one of their resources is running low.

One of the challenges we face is, How do we treat patients in a consistent fashion?' says North Mississippi Health Services Chief Medical Officer Dr. Jeremy Blanchard.

The U.S. Food and Drug Administration approved tocilizumab for emergency use in late June. Two months later, a global shortage of the drug has drawn the concern of the World Health Organization.

Sometimes either those medications or our testing supplies have come at risk, Dr. Blanchard says. Most recently, we have one of our medicationsthat we use with severe respiratory dysfunctions that has a threatened supply chain right now.

The WHO says tocilizumab can play a key part in keeping patients alive and reducing the need for mechanical ventilation for the severely ill.

Very similar to the hydroxychloroquine family (of drugs) used in rheumatoid arthritis, says Hank Norwood, a pharmacist for Allegro Family Clinics.

Now Mississippi hospitals must rely on alternatives.

The steroid inhalers, the steroid packs, the antibiotic packs, and the breathing inhalers, Norwood says.

Dr. Jeremy Blanchard says NMHS hospitals have algorithms to help guide them in choosing the best treatment for a patient.

What they are is, if A happens then do B and if B happens then you do C, he explained. Its based on a positive test and a set of symptoms that says you have COVID.

But Dr. Blanchard says the best way to treat COVID is still to prevent someone from getting it.

If you were going to look at what evidence do we have that really has been effective in treating and managing COVID, the three biggies that come up first are going to be vaccination, masking and monoclonal antibodies, he says.

The WHO says it is working to expand the number of manufacturers of tocilizumab across the globe.

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Effect of Introducing Biologics to Patients with Rheumatoid Arthritis on the Risk of Venous Thromboembolism: a Nationwide Cohort Study – DocWire News

Monday, August 30th, 2021

In the United States, 100,000-300,000 patients die from venous thromboembolism (VTE) each year, with more than 500,000 people related hospitalizations. While in Europe, 500,000 people die from VTE each year. Patients with rheumatoid arthritis are at increased risk of VTE. The use of biologics in patients with rheumatoid arthritis may be associated with an increased risk of VTE. We identified all patients who had been newly approved for Catastrophic Illness Card of rheumatoid arthritis extracted the claims data from the National Health Insurance research database and Registry for Catastrophic Illness Patient Database from 2003 to 2016. VTE was defined as the presence of inpatient VTE diagnostic codes (including DVT or PE) according to the discharge diagnosis protocol. An analysis of VTE variables indicated that the incidence of VTE in the biologic group (14.33/10,000 person-years) was higher than that in the conventional drug group (12.61/10,000 person-years). As assessed by the Cox proportional hazards model, the relative HR for VTE in the biologic group (HR: 1.11; 95% CI 0.79-1.55) versus that in the conventional drug group did not reach a significant difference. In conclusion, this study found no significant differences in risk were observed between the use of conventional DMARDs and biologics.

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Effect of Introducing Biologics to Patients with Rheumatoid Arthritis on the Risk of Venous Thromboembolism: a Nationwide Cohort Study - DocWire News

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East Lake valedictorian goes to Harvard to study medicine and cure moms arthritis – WTSP.com

Monday, August 30th, 2021

Lorena Britton and her mother, Rosa, moved to Boston this month. It marked the fulfillment of a goal the teen set over a decade ago: to attend Harvard University.

TARPON SPRINGS, Fla. Lorena Britton still remembers the moment she found out she would be attending her dream school.

That was December 17, the teen said. That was just like the best day of my life. We got the news at 7 p.m. and I stayed up all night.

The East Lake High School class of 2021 valedictorian only applied to one university. Attending Harvard had always been her goal since the day she came home from elementary school and asked her mother, Rosa, which school was the best in the nation. They even took a trip to Boston when Lorena was eight years old.

Weve had this mutual goal of getting there, said Lorena. Its such a special place to be.

Now, they both are there.

Im very proud, said Rosa, whom her daughter describes as her biggest cheerleader. So far, she hasnt let me down.

In mid-August, Lorena and Rosa packed up everything they owned and left Florida for Boston. It took four days to make the drive from the Sunshine State due to Rosas health issues. Shes been living with increasingly debilitating rheumatoid arthritis since she was 22 years old.

Brushing my teeth is hard, said Rosa, who emigrated from Venezuela knowing very little English two decades ago.

Lorena has been the caretaker for her mother for the last 8-10 years, helping with everyday tasks most able-bodied people take for granted. Her mothers arthritis has gotten progressively worse.

Thats why Lorena chose Harvard.

Its mostly the reason I want to be a doctor to help people like her, said Lorena. I just love learning.

Rheumatoid arthritis has attacked Rosas joints. She has limited mobility and is in constant pain. Lorena hopes her studies in regenerative biology at Harvard will lead to finding a breakthrough treatment or cure for her mothers physical issues.

Its been attacking me very aggressively. I cannot use my hands. I keep my spirits up and try to do my best, be happy, and all I can do is pray to God to see my Lorenas success, said Rosa. My life has been like a trial of fire.

Classes begin on September 1 for Lorena. She is eager to get back to the classroom. For a decade shes been dreaming of this day.

For herself, and her mother.

With modern science and stem cells we can probably find a cure for my moms disease, Lorena said. We depend on each other.

Lorena was awarded $2,000 from Achieva after the credit union heard about her story. Achieva has awarded $26,000 in scholarship funds this year, bringing its total to more than $200,000 in scholarships in the past 14 years.

Lorena plans to get a degree in developmental and regenerative biology.

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East Lake valedictorian goes to Harvard to study medicine and cure moms arthritis - WTSP.com

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Incidence of Venous Thromboembolism in Rheumatoid Arthritis, Results from a "Real-life" Cohort and an Appraisal of Available Literature -…

Monday, August 30th, 2021

Background and Purpose

Rheumatoid arthritis (RA) is associated with an increased risk of venous thromboembolism (VTE) occurrence. In this work, we assessed the incidence and predictive factors of VTE in our real-life cohort of RA patients. To contextualize our results, we reviewed the available literature about this topic, we performed a retrospective analysis of prospectively followed-up patients with RA attending our Rheumatologic Clinic between January 2010 and December 2020.

Each patient was investigated for VTE occurrence. Incident cases were reported as incidence proportion and incidence rate per 1000 person-years at risk. Possible predictive factors were also exploited by regression analyses. Available literature about this topic was also assessed.

In this evaluation, 347 consecutive patients without previous evidence of VTE, attending our Rheumatologic Clinic from 2010 to 2020, were studied. In our real-life cohort, the incidence proportion of VTE was 3.7% (2.7-4.7%) and considering over 1654 person-years, an incidence rate of 7.8 1000 (2.5-11.7). Exploratively assessing predictive factors in our cohort, older age (hazard ratio [HR] 1.07, 95% confidence interval [CI] 1.01-1.14, p = .015), higher body mass index (HR 1.37, 95% CI 1.04-1.80, P = .026), and longer disease duration (HR 1.11, 95% CI 1.03-1.20, P = .006) resulted to be significant predictors of VTE occurrence during the follow-up.In our real-life cohort, VTE burden has been suggested in patients with RA.

Comparing our results with previous data derived from randomized controlled trials and administrative data, some different findings were retrieved about incidence of VTE. Assessing predictive factors, older age, higher body mass index, and longer disease duration resulted to be significant predictors of VTE occurrence during the follow-up. Taking together these observations, a further evaluation of this issue on specific designed studies is needed to provide more generalizable results to the daily clinical practice.

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Incidence of Venous Thromboembolism in Rheumatoid Arthritis, Results from a "Real-life" Cohort and an Appraisal of Available Literature -...

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Animal Expert Shares 5 Things That Will Help Your Dog Live a Longer, Healthier Life – ScienceAlert

Monday, August 30th, 2021

As anyone who has ever lived with a dog will know, it often feels like we don't get enough time with our furry friends. Most dogs only live around ten to 14 years on average though some may naturally live longer, while others may be predisposed to certain diseases that can limit their lifespan.

But what many people don't know is that humans and dogs share many genetic similarities including a predisposition to age-related cancer. This means that many of the things humans can do to be healthier and longer lived may also work for dogs.

Here are just a few ways that you might help your dog live a longer, healthier life.

One factor that's repeatedly linked with longevity across a range of species is maintaining a healthy bodyweight. That means ensuring dogs aren't carrying excess weight, and managing their calorie intake carefully.

Not only will a lean, healthy bodyweight be better for your dog in the long term, it can also help to limit the impact of certain health conditions, such as osteoarthritis.

Carefully monitor and manage your dog's bodyweight through regular weighing or body condition scoring where you look at your dog's physical shape and "score" them on a scale to check whether they're overweight, or at a healthy weight. Using both of these methods together will allow you to identify weight changes and alter their diet as needed.

Use feeding guidelines as a starting point for how much to feed your dog, but you might need to change food type or the amount you feed to maintain a healthy weight as your dog gets older, or depending on how much activity they get.

Knowing exactly how much you are feeding your dog is also a crucial weight-management tool so weigh their food rather than scooping it in by eye.

More generally, good nutrition can be linked to a healthy ageing process, suggesting that what you feed can be as important as how much you feed. "Good" nutrition will vary for each dog, but be sure to look for foods that are safe, tasty and provide all the nutrients your dog needs.

Exercise has many physiological and psychological benefits, both for our dogs (and us). Physical activity can help to manage a dog's bodyweight, and is also associated with anti-ageing effects in other genetically similar species.

While exercise alone won't increase your dog's lifespan, it might help protect you both from carrying excess bodyweight. And indeed, research suggests that "happy" dog walks lead to both happy dogs and people.

Ageing isn't just physical. Keeping your dog's mind active is also helpful. Contrary to the popular adage, you can teach old dogs new tricks and you might just keep their brain and body younger as a result.

Even when physical activity might be limited, explore alternative low-impact games and pursuits, such as scentwork that you and your dog can do together. Using their nose is an inherently rewarding and fun thing for dogs to do, so training dogs to find items by scent will exercise them both mentally and physically.

Other exercise such as hydrotherapy a type of swimming exercise might be a good option especially for dogs who have conditions which affect their ability to exercise as normal.

Like many companion animals, dogs develop a clear attachment to their caregivers. The human-dog bond likely provides companionship and often, dog lovers describe them as a family member.

A stable caregiver-dog bond can help maintain a happy and mutually beneficial partnership between you and your dog. It can also help you recognize subtle changes in your dog's behavior or movement that might signal potential concerns.

Where there is compatibility between caregiver and dog, this leads to a better relationship and even benefits for owners, too, including stress relief and exercise. Sharing positive, fun experiences with your dog, including playing with them, are great for cementing your bond.

Modern veterinary medicine has seen substantial improvements in preventing and managing health concerns in dogs. Successful vaccination and parasite management programs have effectively reduced the incidence of disease in both dogs and humans including toxocariasis, which can be transmitted from dog feces to humans, and rabies, which can be transmitted dog-to-dog or dog-to-human.

Having a good relationship with your vet will allow you to tailor treatments and discuss your dog's needs. Regular health checks can also be useful in identifying any potential problems at a treatable stage such as dental issues or osteoarthritis which can cause pain and negatively impact the dog's wellbeing.

At the end of the day, it's a combination of our dog's genetics and the environment they live in that impacts their longevity. So while we can't change their genetics, there are many things we can do to improve their health that may just help them live a longer, healthier life.

Jacqueline Boyd, Senior Lecturer in Animal Science, Nottingham Trent University.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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The Bat Elixir: Geneticists Suspect that the Flying Mammal Holds the Key to Extended Healthy Life | The Weather Channel – Articles from The Weather…

Monday, August 30th, 2021

A bat in flight.

Bats have developed a pretty bad rap sheet in the last few years. First, pop culture painted these mammals as a form of the blood-sucking Dracula, and then they were villainised for allegedly triggering a pandemic. Indeed, these poor creatures can't seem to catch a break! Aside from being adorable, bats have several other redeeming qualities like being the only mammals capable of flying and finding food even in complete darkness.

Of late, experts in genetics have uncovered a few startling facts about these Chiropterans, which could imply that they may hold the secret to healthy ageing. With the COVID-19 pandemic turning the spotlight on bats, their unique ability to stay alive against unmatched odds has also come under scrutiny.

The relationship between the size of a mammal, its metabolism, and lifespan is relatively straightforward. The larger the mammal, the slower its metabolism is, and this means a longer lifespan. While we humans ourselves are an exception to this rule, these flying mammals also deviate from this trend.

Some bats are known to live for 40 yearsthat's eight times longer than the lifespan of other animals their size! This unusually long lifespan of bats has always aroused the curiosity of scientistsit prompted them to ask the question, what was it that made these bats live longer?

The gene expression pattern in bats is very unique and has been associated with DNA repair, autophagy, immunity and tumour suppression, ensuring an extended health span for bats. Now, scientists are wondering if we could replicate a few such attributes on humans as well!

There's a cap-like structure called the telomere present at the end of each chromosomea microscopic threadlike part of the cell that carries part or all of the genetic material. This unique structure protects your chromosomes from damage. Every time your cells replicate, the chromosome loses just a little bit of the telomere. As time passes, this telomere gets very short, and either rides the wave of ageing or causes the cell to self-destruct. To put it succinctly, the shortening of your telomeres is why you age.

While this seems inevitable, studies conducted in the last few years revealed that the telomeres do not shorten in long-lived species of batslike the Myotis genus. This means that these species can protect their DNA for an unusually long-time in their lifespan.

A bat pup.

It's common knowledge that in humans, the body's ability to heal and repair any damage decreases considerably as we age. But researchers studied the genome of young, middle-aged, and old bats and found that their ability to repair DNA and damage caused by age increased as they grew older.

Another quality that contributes to their longevity is their ability to control their immune responses. With an over-excited immune response, humans tend to succumb to infections like COVID-19 quicker. In COVID-19 patients with regulated immune responses, the risk of ending up on the ventilator is much lower, reveals research.

Similarly, a controlled immune response could be why bats are able to carry numerous deadly pathogens like the coronavirus without succumbing to them easily.

Humans and bats have many similar genes but with a tweak here and a nip there. So, if we could someday discover what factors elicit these controlled immune responses and telomere shortening avoidance in bats and replicate it in humans, it would be a massive leap towards the utopian dream of a healthy, long life!

**

For weather, science, and COVID-19 updates on the go, download The Weather Channel App (on Android and iOS store). It's free!

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Greenland Sharks Live Hundreds of Years; Can These Sharks Teach Humans How to Live Long? – Science Times

Monday, August 30th, 2021

A fishing expedition 15 years ago off the west coast of Greenland led scientists to discover the world's oldest vertebrate, Greenland sharks. This species can live at least 250 years. Scientists see lifestyle and genetics as a possible cause, and gene therapy techniques help humans adopt the same longevity.

Danish marine biologist John Steffensen was on a fishing expedition 15 years ago when he spotted an unusual-looking shark that hung from the boat's edge. Greenland sharks are large, sluggish, and awkwardly proportioned sharks that roam the icy depths of the North Atlantic Ocean and the Gulf of Mexico.

Steffensen and his colleagues published their findings in a study titled "Eye Lens Radiocarbon Reveals Centuries of Longevity in the Greenland Shark(Somniosus microcephalus)," onSciencein 2016. Since then, this cadaverous shark has become a sensation, with scientists worldwide trying to unlock the secret of its longevity, noting that it could show humans how to live long.

(Photo: Wikimedia Commons)Close-up image of a Greenland shark taken at the floe edge of the Admiralty Inlet, Nunavut

According toAtlas Obscura, Greenland sharks were commercially hunted for their oil-rich livers during the first half of the 20th century. However, presently, fishers find them a nuisance since these species feed o valuable halibut. Sometimes, they also get tangled with fishnets that could damage equipment on deck if they could not find a way out.

Steffensen's interest in Greenland sharks peaked when he learned of the extreme longevity of the sharks. They tried scanning the sharks for signs of growth rings but failed and found no evidence of their age.

So, he consulted retired physicist Jan Heinemeier from Denmark's Aarhus University, who gave him the idea of dating eye lenses produced at birth and could be subjected to carbon dating.

The results were astounding, showing that Greenland sharks could live at least 272 years up to 512 years old. In thevideoby Wonder World, they discussed that the oldest Greenland shark was 512 years old found in the North Atlantic, which could also hold the record of being the oldest living vertebrate in the world.

The scientists at first could not believe their findings, questioning whether they have made a mistake or not. Another thing they observed is that older Greenland sharks grow at a slower rate than young ones. The largest they found was 16 feet long, but they could still grow up to 18 feet.

ALSO READ: Two Female Sharks Reproduce Offspring; Recorded as First Case of Asexual Reproduction in Italy

Finding out that there could be sharks swimming in the ocean born during the Renaissance period is extraordinary. Scientists have asked how these creatures could live that long. They believe it might be due to genetics and lifestyle.

According toNBC News, Greenland sharks' longevity might have to do with their extraordinary heart and unique immune systems. The sharks' hearts pump slowly by about one beat per 12 seconds, and they have been beating already for centuries. On the other hand, a human heart beats about once every second and gradually slows down as humans age.

Moreover, DNA sequencing of Greenland sharks shows that genetic mutations in them have given them an immune system that can stop cancer and other infectious diseases.

In the future, scientists hope to transplant the genes to humans to promote long life using gene therapy techniques. However, this technology is in its early years, and more studies are needed to be successful.

RELATED ARTICLE: Godzilla Shark From 300 Million Years Ago Finally Gets New Name, Classified as New Species

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9 Healthy Eating Habits to Live Over A Century, Say Dietitians | Eat This Not That – Eat This, Not That

Monday, August 30th, 2021

You don't have to live in a blue zone to live over a century. "Blue zones" are known to have the densest population of people that live to be over 100located in five different communities around the world. And yet, while these communities are known for being the healthiest and living the longest, the truth is, you don't have to be a community member to reap the same benefits. While genetics do play a role in longevity, setting healthier habits also significantly increases your chances of living long enough to reach that three-digit number.

So what's their secret? If you were to place a microscope on these communities, you would notice that their diets include a variety of real, whole foods. They also focus on eating at the table, sharing meals with others, and regularly moving their bodies.

But what's exactly on their plates? We spoke with a few registered dietitians to look at some of the healthy eating habits that can help you to live over a century, and these tips line up closely with the type of lifestyles lived by those in blue zones. Here are the healthy eating habits you can incorporate into your life today in order to have a happier, healthier tomorrow. Then, be sure to check out our list of The 7 Healthiest Foods to Eat Right Now.

"It is well-known that fruit and vegetables are good for you, but it's important to remember that it's more than just that," says Amy Goodson, MS, RD, CSSD, LD. "Colorful fruits and veggies provide the body with various vitamins, minerals, antioxidants, and plant compounds that help the heart, the gut as well as keep your immune system strong and more! Each color of produce contains a different nutrient package."

RELATED:Get even more healthy eating tips straight to your inbox by signing up for our newsletter!

"While everyone's body and natural genetics are different, fueling your body appropriately is a crucial component if you would like to live over a century," says Ricci-Lee Hotz, MS, RDN at A Taste of Health, LLC and Expert at Testing.com. "Ensuring that you consume a varied diet with a range of different fruits, veggies, lean proteins, whole grain, high fiber carbs, and healthy fat, and balancing them appropriately at each meal and snack is crucial to make sure your body is getting everything it needs to function at its best. In addition, keeping your stress levels down (especially surrounding food) can always help your body stay as healthy as possible, too."

"Following a plant-based diet is one of the best possible dietary choices to live a life with greater quality and quantity," says Trista Best, MPH, RD, LD, and a registered dietitian at Balance One Supplements. "For many who turn to a plant-based diet, their goal is overall health and reduced risk of chronic disease, which culminates in longer life. Among the many benefits of a plant-based diet, including, heart health, weight loss, and diabetes prevention a new secondary benefit is emerging; reduced cancer risk."

Best points out research from the American Institute for Cancer Research which states that one of the best ways to prevent cancer is through dietary means. Focusing on nutrients like fiber, vitamins, minerals, and phytonutrients into your diet is key, and can be found in foods like vegetables, fruit, beans, grains, nuts, and seeds.

If going plant-based does not feel like something that is attainable for you, Best also recommends focusing on a flexitarian approach if you want to live over a century.

"For many, this can be a daunting task and a flexitarian approach may be the best option," she says. "Regardless of where you fall, reducing animal protein in your diet will improve your longevity."

Here are 10 Benefits of Eating a More Plant-Based Diet.

"The healthiest of people fill their plate with nutrient-rich foods like whole grains, fruits, vegetables, lean protein, dairy, and healthy fat, but they also allow for pleasure foods," says Goodson. "The key to a long, happy life is balance. The majority of the time, 80%, eat foods to fuel your body and keep it strong. Then 20% of the time enjoy vacations, holidays, and desserts with the people you love. It's the best plan for the body and the soul."

It's all about setting healthier habits for yourself! Here are5 Healthy Dessert Habits For A Flat Belly.

"It's important to not overeat," Rachel Paul, PhD, RD from CollegeNutritionist.com. "Overeating calories, even of healthier foods, leads to weight gain. Those with overweight or obese bodies are more likely to develop diseases such as diabetes, heart disease, and some cancers, which can lead to premature death."

One of the best ways to combat overeating is to start paying attention to your body's hunger and fullness clues, portioning out your meals, and setting specific times for meals and snacks throughout the day. Overeating and mindless snacking can easily come hand-in-hand, so it's important to set healthy snacking habits that will help you feel full, prevent overeating, and help you ultimately live over a century.

"As we age, we typically lose 2 to 3% muscle mass per decade," says Goodson. "That can lead to falls, bone breaks, and instability as we age. The key? Power up with lean protein at all meals and snacks. Protein helps and builds and repairs muscles helping to keep your body strong as you age. Including foods like lean beef, poultry, fish, eggs, dairy, beans, and legumes can all help you amp up your protein."

"As a dietitian, I'm always telling people to 'eat the rainbow' because all the different colored foods represent different phytonutrients that help keep us healthy as we age," says Mackenzie Burgess, RDN and recipe developer at Cheerful Choices. "One beneficial type of phytonutrient you'll find in colorful fruits, vegetables, and other plant foods are compounds called 'flavonoids.' In fact, recent research has proven these flavonoids to be helping in maintaining our brain health long-term. Flavonoid-rich foods include onions, berries, dark greens, herbs, broccoli, cauliflower, dark chocolate, soy, and citrus fruits."

To easily incorporate flavonoid-rich foods into your diet, Burgess says "For breakfast try mashing together berries and chia seeds to make your own jam. Then, for lunch, blend cauliflower into rice or find it in flatbread form to pair with your favorite protein. Finally, for dinner, try stirring extra onions and herbs into a one-pot curry."

"To keep our brains sharp and to prevent cognitive decline, what we eat can make a difference," says Lisa R. Young, PhD, RDN, author of Finally Full, Finally Slim and a member of our medical expert board. "Foods high in certain vitamins, antioxidants, and phytochemicals may help to boost brain health. Deep red foods such as tomatoes and watermelon contain the antioxidant lycopene which fights free radicals that come with aging. Leafy greens such as kale and spinach are rich in vitamins E and K which may prevent memory loss and help reduce our 'brain age.'"

Related:Why You Need Antioxidants In Your DietAnd How To Eat More Of Them

"As we age, our metabolism tends to slow down so it is important to watch calories and exercise more to avoid weight gain," says Young. "It turns out that maintaining a steady weight and avoiding yo-yo dieting is equally important. The centenarians from Okinawa, known to live long and healthy lives, were known to keep their calories down and their weight steady. Maintaining a healthy body mass index (BMI) has been associated with lower rates of heart disease and certain cancers."

For more, be sure to read our list of The 6 Best Diets That Will Make You Live Longer, Say Dietitians.

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Dad with multiple sclerosis who fought for treatment in Panama during Covid restrictions finds first round is ‘reaping rewards’ – South West Londoner

Monday, August 30th, 2021

A former junior motorsport racer with multiple sclerosis who battled against the odds to receive experimental stem cell treatment in Panama in April is already noticing improvements in his condition.

Alister Bailey, 39, a former Barnes resident, travelled to the Stem Cell Institute with his wife Gemma, despite warnings they would not be let in to Panama due to coronavirus travel restrictions.

MS is an autoimmune disease that can affect the brain and spinal cord. Common symptoms include mobility problems, vision problems, muscle spasms, fatigue and speech difficulties.

Before Panama, Alister couldnt hold a cup of tea, but now his hands have stopped shaking and he can pour a drink without spilling it. He has also noticed an improvement in his eyesight.

Gemma said: This might seem trivial but its a huge physical change.Thats a really positive sign and certainly encouraging for us in terms of the next round.

We have seen some positive signs already which is amazing because we didnt really have any expectations this time round to be honest; it was more to stop the deterioration.

He really believes it will work and he feels something is happening.

The Baileys are currently fundraising to get Alister back to Panama for a second round of treatment in November.

The pair were supposed to fly out to Panama for the first round in January after raising 22,500, but coronavirus put a stop to those plans.

Travel restrictions meant they had to delay the trip until the end of April but, even then, it was not an easy ride.

Read below about their rollercoaster journey:

The pair opted for experimental mesenchymal stem cell therapy because treatment options for progressive MS are limited.

A year after he married Gemma, Alister started experiencing episodes where he wasnt able to walk and then he went blind for two days in 2012.

Since receiving his diagnosis, Alister has been on a drug for ten years to slow symptom progression. But Gemma said his condition has rapidly deteriorated in the past three years. While he does not use a wheelchair at home, he cannot walk any long distance unsupported.

She said: Theres no cure for progressive MS so this treatment in Panama is his only hope.

Alister didnt qualify for anything on the NHS which was pretty disheartening.

We have various doctor friends, some of them researching stem cell treatments for different illnesses but they said this is where medicine is going in the future.

The Stem Cell Institute administers mesenchymal stem cells (MSCs) which are recovered from donated umbilical cords and grown in labs.

MSCs are adult cells which can produce other cells like muscle. This is why researchers are interested in testing whether they can protect nerves from more damage and repair the original damage.

The Baileys are hoping to see the best benefits of the treatment after two or three rounds and have prepared themselves for potentially five visits.

They have planned fundraising events to get together the funds needed for November.

On 17 July, Alisters 67-year-old dad Chris took on the Surrey Hills Epic Off-Road Challenge which involves 125km of off-road mountain biking.

Gemma is organising a charity dinner and her friend Claire is running the Lulworth Cove Trail Challenge which involves running along the coastline.

Their friend Jonny Wright has already raised $14,400 as he prepares to cycle 2,500 miles from Maine to Florida in 30 days starting on 27 August.

Their hope is that the treatment will stimulate repair of the damaged tissues so that Alister can play football with his son again.

You can follow the familys journey on their Instagram page.

You can donate to their fundraiser here.

Credit for all photos: Gemma and Alister Bailey.

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Dad with multiple sclerosis who fought for treatment in Panama during Covid restrictions finds first round is 'reaping rewards' - South West Londoner

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Multiple sclerosis and the experimental treatment giving families hope – South West Londoner

Monday, August 30th, 2021

Multiple sclerosis is an autoimmune disease that can affect the brain and spinal cord, and it is estimated that 130,000 people in the UK have the condition.

There are drugs available to slow the onset of symptoms but treatment options for progressive MS are limited and there is currently no cure.

At the end of July, the US Food and Drug Administration authorised a Phase 2 clinical trial at Hope Biosciences Stem Cell Research Foundation in Texas.

The future of MS treatment is exciting; scientists think solutions for all types of MS could be in their late stage trials by 2025.

But what are the options for those living with progressive MS right now? Some are desperate to halt their symptom deterioration.

Increasingly, they are looking to experimental treatments like the one offered by Panamas Stem Cell Institute.

Alister Bailey and Liam Egalton both raised tens of thousands of pounds to travel to Panama for mesenchymal stem cell therapy. To find out about their turbulent journeys during the pandemic and learn more about ongoing MS treatment research projects, read the full story here:

https://swlondoner.shorthandstories.com/multiple-sclerosis-and-the-experimental-treatment-giving-families-hope/index.html

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Global Regenerative Medicine Market (2021 to 2030) – by Product, Material, Application and Region – ResearchAndMarkets.com – Business Wire

Monday, August 30th, 2021

DUBLIN--(BUSINESS WIRE)--The "Regenerative Medicine Market by Product, by Material, by Application - Global Opportunity Analysis and Industry Forecast, 2021 - 2030" report has been added to ResearchAndMarkets.com's offering.

The global regenerative medicine market is expected to reach USD 172.15 billion by 2030 from USD 13.96 billion in 2020, at a CAGR of 28.9%.

Companies Mentioned

Regenerative Medicine are used to regenerate, repair, replace or restore tissues and organs damaged by diseases or due to natural ageing. These medicines help in the restoration of normal cell functions and are widely used to treat various degenerative disorders such as cardiovascular disorders, orthopedic disorders and others.

The rising demand for organ transplantation and increasing awareness about the use of regenerative medicinal therapies in organ transplantation along with implementation of the 21st Century Cures Act, a U.S. law enacted by the 114th United States Congress in December 2016 are creating growth opportunities in the market. However, high cost of treatment and stringent government regulations are expected to hinder the market growth.

The global regenerative medicine market is segmented based on product type, material, application, and geography. Based on product type, the market is classified into cell therapy, gene therapy, tissue engineering, and small molecule & biologic. Depending on material, it is categorized into synthetic material, biologically derived material, genetically engineered material, and pharmaceutical. Synthetic material is further divided into biodegradable synthetic polymer, scaffold, artificial vascular graft material, and hydrogel material. Biologically derived material is further bifurcated into collagen and xenogenic material. Genetically engineered material is further segmented into deoxyribonucleic acid, transfection vector, genetically manipulated cell, three-dimensional polymer technology, transgenic, fibroblast, neural stem cell, and gene-activated matrices. Pharmaceutical is further divided into small molecule and biologic. By application, it is categorized into cardiovascular, oncology, dermatology, musculoskeletal, wound healing, ophthalmology, neurology, and others. Geographically, it is analyzed across four regions, i.e., North America, Europe, Asia-Pacific, and RoW.

Key Topics Covered:

1. Introduction

2. Regenerative Medicine Market - Executive Summary

3. Porter's Five Force Model Analysis

4. Market Overview

4.1. Market Definition and Scope

4.2. Market Dynamics

5. Global Regenerative Medicine Market, by Product Type

5.1. Overview

5.2. Cell Therapy

5.3. Gene Therapy

5.4. Tissue Engineering

5.5. Small Molecules & Biologics

6. Global Regenerative Medicine Market, by Material

6.1. Overview

6.2. Synthetic Materials

6.3. Biologically Derived Materials

6.4. Genetically Engineered Materials

6.5. Pharmaceuticals

7. Global Regenerative Medicine Market, by Application

7.1. Overview

7.2. Cardiovascular

7.3. Oncology

7.4. Dermatology

7.5. Musculoskeletal

7.6. Wound Healing

7.7. Opthalomolgy

7.8. Neurology

7.9. Others

8. Global Regenerative Medicine Market, by Region

8.1. Overview

8.2. North America

8.3. Europe

8.4. Asia-Pacific

8.5. Rest of World

9. Company Profile

9.1. Integra Lifesciences Corporation

9.2. Abbvie Inc.

9.3. Merck Kgaa

9.4. Medtronic plc

9.5. Thermo Fisher Scientific Inc.

9.6. Smith+Nephew

9.7. Becton, Dickinson and Company

9.8. Baxter International Inc

9.9. Cook Biotech

9.10. Organogenesis Inc

For more information about this report visit https://www.researchandmarkets.com/r/nzud5i

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Global Regenerative Medicine Market (2021 to 2030) - by Product, Material, Application and Region - ResearchAndMarkets.com - Business Wire

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Global Cryopreservation Equipment Market Report 2021-2028 – Growing Acceptance for Regenerative Medicine & Increasing Needs of Biobanking…

Monday, August 30th, 2021

DUBLIN--(BUSINESS WIRE)--The "Cryopreservation Equipment Market Forecast to 2028 - COVID-19 Impact and Global Analysis by Type, Cryogen Type, Application, End User, and Geography" report has been added to ResearchAndMarkets.com's offering.

Freezers Segment to Contribute Major Share to Cryopreservation Equipment Market

Cryopreservation Equipment Market to reach US$ 11,255.02 million by 2028 from US$ 5,798.82 million in 2021; it is estimated to grow at a CAGR of 9.9%

The report highlights the trends prevailing in the market along with the market drivers and deterrents. The factors such as growing acceptance for regenerative medicine and increasing needs of biobanking practices drive the market growth. However, stringent regulatory requirements hinder the cryopreservation equipment market growth.

Cryopreservation plays an important part in the field of regenerative medicine as it facilitates stable and secure storage of cells and other related components for a prolonged time. Regenerative medicine enables replacing diseased or damaged cells, tissues, and organs by retrieving their normal function through stem cell therapy.

Owing to the advancements in the medical technology, stem cell therapy is now being considered as an alternative to traditional drug therapies in the treatment of a wide range of chronic diseases, including diabetes and neurodegenerative diseases.

Moreover, the US Food and Drug Administration (FDA) has approved blood-forming stem cells. The blood-forming stem cells are also known as hematopoietic progenitor cells that are derived from umbilical cord blood. The growing approvals for stem cell and gene therapies are eventually leading to the high demand for cryopreservation equipment. Following are a few instances of stem cell and gene therapies approved by the FDA and other regulatory bodies.

Based on type, the cryopreservation equipment market is segmented into freezers, sample preparation systems, and accessories. In 2020, the freezers segment held the largest share of the market, and it is expected to register the highest CAGR during 2021-2028. In ultracold freezers, liquid nitrogen is used for the successful preservation of more complex biological structures by virtually seizing all biological activities.

The COVID-19 pandemic has had a mixed impact on the cryopreservation equipment market. Restricted access to family planning services as well as diverted focus of people due to economic uncertainties and recession, and disturbed work-life balance have led to rise in egg and embryo freezing activities at fertility clinics during the pandemic.

As a result, the rising use of cryopreservation equipment is boosting the market growth. Furthermore, supply chain disruption caused due to congestion of ports and disturbances in other transport means has substantially affected the distribution of cryopreservation equipment and other accessories.

Market players are launching new and innovative products and services to maintain their position in the cryopreservation equipment market. In May 2021, Stirling Ultracold has been acquired by BioLife Solutions, Inc for cell and gene therapies and the broader biopharma market. In return for all of Stirling's outstanding shares, BioLife issued 6,646,870 shares of ordinary stock.

Key Market Dynamics

Market Drivers

Market Restraints

Market Opportunities

Future Trends

The report segments the global cryopreservation equipment market as follows:

By Type

By Cryogen Type

By Application

By End User

Companies Mentioned

For more information about this report visit https://www.researchandmarkets.com/r/tjgti5

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Global Cryopreservation Equipment Market Report 2021-2028 - Growing Acceptance for Regenerative Medicine & Increasing Needs of Biobanking...

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Worldwide Regenerative Medicine Industry to 2030 – Featuring AbbVie, Medtronic and Thermo Fisher Scientific Among Others – GlobeNewswire

Monday, August 30th, 2021

Dublin, Aug. 27, 2021 (GLOBE NEWSWIRE) -- The "Regenerative Medicine Market by Product, by Material, by Application - Global Opportunity Analysis and Industry Forecast, 2021 - 2030" report has been added to ResearchAndMarkets.com's offering.

The global regenerative medicine market is expected to reach USD 172.15 billion by 2030 from USD 13.96 billion in 2020, at a CAGR of 28.9%. Regenerative Medicine are used to regenerate, repair, replace or restore tissues and organs damaged by diseases or due to natural ageing. These medicines help in the restoration of normal cell functions and are widely used to treat various degenerative disorders such as cardiovascular disorders, orthopedic disorders and others.

The rising demand for organ transplantation and increasing awareness about the use of regenerative medicinal therapies in organ transplantation along with implementation of the 21st Century Cures Act, a U.S. law enacted by the 114th United States Congress in December 2016 are creating growth opportunities in the market. However, high cost of treatment and stringent government regulations are expected to hinder the market growth.

The global regenerative medicine market is segmented based on product type, material, application, and geography. Based on product type, the market is classified into cell therapy, gene therapy, tissue engineering, and small molecule & biologic. Depending on material, it is categorized into synthetic material, biologically derived material, genetically engineered material, and pharmaceutical. Synthetic material is further divided into biodegradable synthetic polymer, scaffold, artificial vascular graft material, and hydrogel material. Biologically derived material is further bifurcated into collagen and xenogenic material. Genetically engineered material is further segmented into deoxyribonucleic acid, transfection vector, genetically manipulated cell, three-dimensional polymer technology, transgenic, fibroblast, neural stem cell, and gene-activated matrices. Pharmaceutical is further divided into small molecule and biologic. By application, it is categorized into cardiovascular, oncology, dermatology, musculoskeletal, wound healing, ophthalmology, neurology, and others. Geographically, it is analyzed across four regions, i.e., North America, Europe, Asia-Pacific, and RoW.

The key players operating in the global regenerative medicine market include Integra Lifesciences Corporation, AbbVie Inc., Merck KGaA, Medtronic, Thermo Fisher Scientific Inc., Smith+Nephew, Becton, Dickinson and Company, Baxter International Inc, Cook Biotech, and Organogenesis Inc., among others.

Key Topics Covered:

1. Introduction

2. Regenerative Medicine Market - Executive Summary

3. Porter's Five Force Model Analysis

4. Market Overview4.1. Market Definition and Scope4.2. Market Dynamics

5. Global Regenerative Medicine Market, by Product Type5.1. Overview5.2. Cell Therapy5.3. Gene Therapy5.4. Tissue Engineering5.5. Small Molecules & Biologics

6. Global Regenerative Medicine Market, by Material6.1. Overview6.2. Synthetic Materials6.3. Biologically Derived Materials6.4. Genetically Engineered Materials6.5. Pharmaceuticals

7. Global Regenerative Medicine Market, by Application7.1. Overview7.2. Cardiovascular7.3. Oncology7.4. Dermatology7.5. Musculoskeletal7.6. Wound Healing7.7. Opthalomolgy7.8. Neurology7.9. Others

8. Global Regenerative Medicine Market, by Region8.1. Overview8.2. North America8.3. Europe8.4. Asia-Pacific8.5. Rest of World

9. Company Profile9.1. Integra Lifesciences Corporation9.2. Abbvie Inc.9.3. Merck Kgaa9.4. Medtronic plc9.5. Thermo Fisher Scientific Inc.9.6. Smith+Nephew9.7. Becton, Dickinson and Company9.8. Baxter International Inc9.9. Cook Biotech9.10. Organogenesis Inc

For more information about this report visit https://www.researchandmarkets.com/r/pl6r1p

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Worldwide Regenerative Medicine Industry to 2030 - Featuring AbbVie, Medtronic and Thermo Fisher Scientific Among Others - GlobeNewswire

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2 surgeons weigh in on the most promising areas of regenerative medicine – Becker’s Orthopedic & Spine

Monday, August 30th, 2021

Regenerative medicine is a growing area of orthopedic treatment. Two orthopedic surgeons told Becker's what they found the most exciting about its development.

Ask Orthopedic Surgeons is a weekly series of questions posed to orthopedic surgeons around the country about clinical, business and policy issues affecting orthopedic care. We invite all orthopedic surgeon and specialist responses.

Next week's question: How will joint replacement surgical robots improve in the next 10 years?

Please send responses to Carly Behm at cbehm@beckershealthcare.com by 5 p.m. CDT Tuesday, Aug. 31.

Note: Responses were edited for style.

Question: What area of regenerative medicine holds the most promise for orthopedics?

Mihir Patel, MD. OrthoIndy (Indianapolis): Regenerative medicine is a truly exciting frontier in medicine. In orthopedics, bone graft implants and substitutes are helping patients return to normal activities. The implants can be used in index operations as well as revisions for a variety of orthopedic procedures including acute stress reactions, stress fractures not conducive to metal fixation, and subchondral procedures. The evolution of orthopedic implants from metal to plastic, and now bone is improving outcomes for patients and broadening our arsenal as surgeons to help patients heal. The bone graft substitutes are reducing comorbidities of graft harvesting. Additionally, they are adding to the value proposition for patients who may have difficulty healing bone defects, nonunions, and osteoporosis.

Much like advances in cancer therapies over the past decade, bone graft substitutes have the potential for personalized, targeted medicine for these diagnoses as biomarkers become more available to help clinicians really pinpoint at the molecular level why some heal more quickly than others. Finally, regenerative medicine includes mostly outpatient procedures with sterile kits that are easily transported, giving orthopedic surgeons the confidence in the manufacturing and sterilization process.

Jason Snibbe, MD. Snibbe Orthopedics (Los Angeles): I think the use of biologics from plasma and bone marrow have the most promise right now to help a variety of injuries in orthopedics. We are able to help people recover without surgery and use their own tissue to heal, specifically in labral tears of the hip and meniscus tears in the knee.

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2 surgeons weigh in on the most promising areas of regenerative medicine - Becker's Orthopedic & Spine

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