Dzierzak, E. & Philipsen, S. Erythropoiesis: Development and differentiation. Cold Spring Harb. Perspect. Med. 3, a011601a011601 (2013).
PubMed PubMed Central Article CAS Google Scholar
Hattangadi, S. M., Wong, P., Zhang, L., Flygare, J. & Lodish, H. F. From stem cell to red cell: Regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications. Blood 118, 62586268 (2011).
CAS PubMed PubMed Central Article Google Scholar
Mei, Y., Liu, Y. & Ji, P. Understanding terminal erythropoiesis: An update on chromatin condensation, enucleation, and reticulocyte maturation. Blood Rev. 46, 100740 (2021).
CAS PubMed Article Google Scholar
Steinman, R. A. Cell cycle regulators and hematopoiesis. Oncogene 21, 34033413 (2002).
CAS PubMed Article Google Scholar
Walkley, C. R., Sankaran, V. G. & Orkin, S. H. Rb and hematopoiesis: Stem cells to anemia. Cell Div. 3, 13 (2008).
PubMed PubMed Central Article CAS Google Scholar
Teixeira, L. K. & Reed, S. I. Ubiquitin ligases and cell cycle control. Annu. Rev. Biochem. 82, 387414 (2013).
CAS PubMed Article Google Scholar
Zhou, Z., He, M., Shah, A. A. & Wan, Y. Insights into APC/C: From cellular function to diseases and therapeutics. Cell Div. 11, 118 (2016).
Article CAS Google Scholar
Chang, L. & Barford, D. Insights into the anaphase-promoting complex: A molecular machine that regulates mitosis. Curr. Opin. Struct. Biol. 29, 19 (2014).
CAS PubMed Article Google Scholar
Eguren, M., Manchado, E. & Malumbres, M. Non-mitotic functions of the anaphase-promoting complex. Semin. Cell Dev. Biol. 22, 572578 (2011).
CAS PubMed Article Google Scholar
Qiao, X., Zhang, L., Gamper, A. M., Fujita, T. & Wan, Y. APC/C-Cdh1: From cell cycle to cellular differentiation and genomic integrity. Cell Cycle 9, 39043912 (2010).
CAS PubMed PubMed Central Article Google Scholar
Wsch, R., Robbins, J. A. & Cross, F. R. The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression. Oncogene 29, 110 (2010).
PubMed Article CAS Google Scholar
Engelbert, D., Schnerch, D., Baumgarten, A. & Wsch, R. The ubiquitin ligase APCCdh1 is required to maintain genome integrity in primary human cells. Oncogene 27, 907917 (2008).
CAS PubMed Article Google Scholar
Garca-Higuera, I. et al. Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat. Cell Biol. 10, 802811 (2008).
PubMed Article CAS Google Scholar
Sigl, R. et al. Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis. J. Cell Sci. 122, 42084217 (2009).
CAS PubMed Article Google Scholar
Yuan, X., Srividhya, J., De Luca, T., Lee, J.-H.E. & Pomerening, J. R. Uncovering the role of APC-Cdh1 in generating the dynamics of S-phase onset. Mol. Biol. Cell 25, 441456 (2014).
PubMed PubMed Central Article Google Scholar
Greil, C. et al. The role of APC/CCdh1 in replication stress and origin of genomic instability. Oncogene 35, 30623070 (2016).
CAS PubMed Article Google Scholar
Garzn, J. et al. Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1. Oncogene 36, 58085818 (2017).
PubMed Article CAS Google Scholar
Kimata, Y. APC/C ubiquitin ligase: Coupling cellular differentiation to G1/G0 phase in multicellular systems. Trends Cell Biol. 29, 591603 (2019).
CAS PubMed Article Google Scholar
Sigrist, S. J. & Lehner, C. F. Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell 90, 671681 (1997).
CAS PubMed Article Google Scholar
Delgado-Esteban, M., Garca-Higuera, I., Maestre, C., Moreno, S. & Almeida, A. APC/C-Cdh1 coordinates neurogenesis and cortical size during development. Nat. Commun. 4, 2879 (2013).
ADS PubMed Article CAS Google Scholar
Eguren, M. et al. The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors. Nat. Commun. 4, 2880 (2013).
ADS PubMed Article CAS Google Scholar
Holt, J. E. et al. The APC/C activator FZR1 is essential for meiotic prophase I in mice. Development 141, 13541365 (2014).
CAS PubMed Article Google Scholar
Li, W., Wu, G. & Wan, Y. The dual effects of Cdh1/APC in myogenesis. FASEB J. 21, 36063617 (2007).
CAS PubMed Article Google Scholar
Wu, G. et al. The anaphase-promoting complex coordinates initiation of lens differentiation D. Mol. Biol. Cell 18, 10181029 (2007).
CAS PubMed PubMed Central Article Google Scholar
Koulnis, M. et al. Identification and analysis of mouse erythroid progenitors using the CD71/TER119 flow-cytometric assay. J. Vis. Exp. https://doi.org/10.3791/2809 (2011).
Article PubMed PubMed Central Google Scholar
de Boer, J. et al. Transgenic mice with hematopoietic and lymphoid specific expression of Cre. Eur. J. Immunol. 33, 314325 (2003).
PubMed Article Google Scholar
Bennett, L. F., Liao, C. & Paulson, R. F. Stress Erythropoiesis Model Systems 91102 (Springer, 2018). https://doi.org/10.1007/978-1-4939-7428-3_5.
Book Google Scholar
Swartz, K. L. et al. E2F2 promotes nuclear condensation and enucleation of terminally differentiated erythroblasts. Mol. Cell. Biol. 37, 110 (2017).
Article Google Scholar
Farrs, J. et al. PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors. Cell Death Differ. 22, 11441157 (2015).
PubMed Article CAS Google Scholar
Liu, J. et al. Quantitative analysis of murine terminal erythroid differentiation in vivo: Novel method to study normal and disordered erythropoiesis. Blood 121, e43e49 (2013).
CAS PubMed PubMed Central Article Google Scholar
Kozar, K. et al. Mouse development and cell proliferation in the absence of D-cyclins. Cell 118, 477491 (2004).
CAS PubMed Article Google Scholar
Sankaran, V. G. et al. Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes Dev. 26, 20752087 (2012).
CAS PubMed PubMed Central Article Google Scholar
Spike, B. T. & Macleod, K. F. The Rb tumor suppressor in stress responses and hematopoietic homeostasis. Cell Cycle 4, 4245 (2005).
CAS PubMed Article Google Scholar
Sankaran, V. G., Orkin, S. H. & Walkley, C. R. Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. Genes Dev. 22, 463475 (2008).
CAS PubMed PubMed Central Article Google Scholar
Kinross, K. M., Clark, A. J., Iazzolino, R. M. & Humbert, P. O. E2f4 regulates fetal erythropoiesis through the promotion of cellular proliferation. Blood 108, 886895 (2006).
CAS PubMed Article Google Scholar
Hu, T. et al. Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia. Blood 119, 45324542 (2012).
CAS PubMed PubMed Central Article Google Scholar
Ghazaryan, S. et al. Inactivation of Rb and E2f8 synergizes to trigger stressed DNA replication during erythroid terminal differentiation. Mol. Cell. Biol. 34, 28332847 (2014).
PubMed PubMed Central Article CAS Google Scholar
Alvarez, S. et al. Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality. Nat. Commun. 6, 8548 (2015).
ADS CAS PubMed Article Google Scholar
Ishizawa, J. et al. The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress. Cancer Sci. 102, 967974 (2011).
CAS PubMed Article Google Scholar
He, C. et al. c-myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo. Development 135, 24672477 (2008).
CAS PubMed Article Google Scholar
Dirlam, A., Spike, B. T. & Macleod, K. F. Deregulated E2f2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts. Mol. Cell. Biol. 27, 87138728 (2007).
CAS PubMed PubMed Central Article Google Scholar
Cohen, M. et al. Unbiased transcriptome signature of in vivo cell proliferation reveals pro- and antiproliferative gene networks. Cell Cycle 12, 29923000 (2013).
CAS PubMed PubMed Central Article Google Scholar
Boekhout, M. et al. Feedback regulation between atypical E2Fs and APC/C-Cdh1 coordinates cell cycle progression. EMBO Rep. 17, 414427 (2016).
CAS PubMed PubMed Central Article Google Scholar
Clijsters, L. et al. Cyclin F controls cell-cycle transcriptional outputs by directing the degradation of the three activator E2Fs. Mol. Cell 74, 12641277 (2019).
CAS PubMed PubMed Central Article Google Scholar
Yuan, R. et al. Cyclin F-dependent degradation of E2F7 is critical for DNA repair and G2-phase progression. EMBO J. 38, 20 (2019).
Google Scholar
Wasserman, D. et al. Cell cycle oscillators underlying orderly proteolysis of E2F8. Mol. Biol. Cell 31, 725740 (2020).
CAS PubMed PubMed Central Article Google Scholar
Choudhury, R. et al. APC/C and SCF(cyclin F) constitute a reciprocal feedback circuit controlling S-phase entry. Cell Rep. 16, 33593372 (2016).
CAS PubMed PubMed Central Article Google Scholar
Angulo-Ibez, M. et al. Erk5 contributes to maintaining the balance of cellular nucleotide levels and erythropoiesis. Cell Cycle 14, 38643876 (2015).
PubMed PubMed Central Article CAS Google Scholar
Bracken, A. P., Ciro, M., Cocito, A. & Helin, K. E2F target genes: Unraveling the biology. Trends Biochem. Sci. 29, 409417 (2004).
CAS PubMed Article Google Scholar
Hayashi, S., Lewis, P., Pevny, L. & McMahon, A. P. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech. Dev. 119, S97S101 (2002).
PubMed Article Google Scholar
Read more from the original source:
Efficient terminal erythroid differentiation requires the APC/C cofactor Cdh1 to limit replicative stress in erythroblasts | Scientific Reports -...
- 001 Strange lesions after stem-cell therapy [Last Updated On: June 25th, 2010] [Originally Added On: June 25th, 2010]
- 002 Pat McCrory will do the right thing. He supports non-embryonic stem cell research. - Video [Last Updated On: October 13th, 2011] [Originally Added On: October 13th, 2011]
- 003 The potential of stem cells.flv - Video [Last Updated On: October 15th, 2011] [Originally Added On: October 15th, 2011]
- 004 StemEnhance is the Biggest Scientific Medical breakthrough of our time - World Exclusive! - Video [Last Updated On: October 16th, 2011] [Originally Added On: October 16th, 2011]
- 005 Hiv Positive Man Cured - Video [Last Updated On: October 16th, 2011] [Originally Added On: October 16th, 2011]
- 006 Invitrx "Reluma" with Habib Torfi - Video [Last Updated On: October 17th, 2011] [Originally Added On: October 17th, 2011]
- 007 Negative Campaign against Bonnie Marge Westerford - Video [Last Updated On: October 20th, 2011] [Originally Added On: October 20th, 2011]
- 008 HIV Resistant Genes...Rhesus Negative, Excess PK [Last Updated On: October 20th, 2011] [Originally Added On: October 20th, 2011]
- 009 Insidermedicine in 60 - December 7, 2007 - Video [Last Updated On: October 20th, 2011] [Originally Added On: October 20th, 2011]
- 010 Stem Cell Therapy - BioLogic Anti-Aging Skin Cream - Video [Last Updated On: October 20th, 2011] [Originally Added On: October 20th, 2011]
- 011 Stem Cell Research (Government Hilbrands) - Video [Last Updated On: October 20th, 2011] [Originally Added On: October 20th, 2011]
- 012 Stem Cell News ISCO.MP4 - Video [Last Updated On: October 20th, 2011] [Originally Added On: October 20th, 2011]
- 013 N5-FG-108-all_30fps.AVI - Video [Last Updated On: October 20th, 2011] [Originally Added On: October 20th, 2011]
- 014 Stem cell [Last Updated On: October 21st, 2011] [Originally Added On: October 21st, 2011]
- 015 Steam Cell Reasearch - Video [Last Updated On: October 24th, 2011] [Originally Added On: October 24th, 2011]
- 016 Meat from a petri dish may be on the menu soon :oP - Video [Last Updated On: October 26th, 2011] [Originally Added On: October 26th, 2011]
- 017 Mmmm meat from a petri dish may be on the menu soon - Video [Last Updated On: October 26th, 2011] [Originally Added On: October 26th, 2011]
- 018 Parents of a CP Girl - Talk about Stem Cell Treatment Experience (2) - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- 019 George Somlo, MD - What is triple negative breast cancer? | City of Hope - Video [Last Updated On: October 28th, 2011] [Originally Added On: October 28th, 2011]
- 020 Stem Enhance - Stem Cell Enhancer - Video [Last Updated On: October 28th, 2011] [Originally Added On: October 28th, 2011]
- 021 VistaGen's Cardiac OrganDots(TM) Produced for Drug Rescue - Video [Last Updated On: November 10th, 2011] [Originally Added On: November 10th, 2011]
- 022 The Power of Stem Cells - Video [Last Updated On: November 10th, 2011] [Originally Added On: November 10th, 2011]
- 023 Adult stem cell treatment, quality and testing - Video [Last Updated On: November 26th, 2011] [Originally Added On: November 26th, 2011]
- 024 Cord Blood Stem Cell Transfusion Saves 3-Year-Old Child - Video [Last Updated On: December 7th, 2011] [Originally Added On: December 7th, 2011]
- 025 Dr. Uma Lakshimipathy presents Generation of Transgene-Free Induced Pluripotent Stem Cells - Video [Last Updated On: December 28th, 2011] [Originally Added On: December 28th, 2011]
- 026 StemFlo - Blood Circulation Enhancer, Antioxidant and More!.flv - Video [Last Updated On: January 1st, 2012] [Originally Added On: January 1st, 2012]
- 027 Dr Tony Talebi discusses treatment of multiple myeloma patients with Dr Ratzan - Video [Last Updated On: January 2nd, 2012] [Originally Added On: January 2nd, 2012]
- 028 Dr Tony Talebi discusses stem cell transplantation in Myeloma with Dr Ratzan - Video [Last Updated On: January 2nd, 2012] [Originally Added On: January 2nd, 2012]
- 029 Frank Young Joins Bioheart as Financial Consultant [Last Updated On: January 31st, 2012] [Originally Added On: January 31st, 2012]
- 030 Scientists use old theory to discover new targets in fight against breast cancer [Last Updated On: February 13th, 2012] [Originally Added On: February 13th, 2012]
- 031 Salk Scientists Use an Old Theory to Discover New Targets in the Fight Against Breast Cancer [Last Updated On: February 13th, 2012] [Originally Added On: February 13th, 2012]
- 032 Life Technologies Scientist Uma Lakshmipathy presents, "Solving Challenges in the Generation of Induced Pluripotent ... [Last Updated On: February 15th, 2012] [Originally Added On: February 15th, 2012]
- 033 Bioheart to Present at BioFlorida's Saturday Exchange [Last Updated On: February 15th, 2012] [Originally Added On: February 15th, 2012]
- 034 Nasal Stem Cells Show Promise in Repairing Spinal Cord Damage Caused by Contusion [Last Updated On: February 22nd, 2012] [Originally Added On: February 22nd, 2012]
- 035 Gentium Responds to the EMA's Day 120 List of Questions for Defibrotide MAA [Last Updated On: February 22nd, 2012] [Originally Added On: February 22nd, 2012]
- 036 Bone Marrow Prolotherapy at Caring Medical - Dr. Ross Hauser - Video [Last Updated On: February 23rd, 2012] [Originally Added On: February 23rd, 2012]
- 037 Bacterin International Holdings, Inc. Schedules Fourth Quarter 2011 Financial Earnings Conference Call [Last Updated On: February 25th, 2012] [Originally Added On: February 25th, 2012]
- 038 Mass. General researchers isolate egg-producing stem cells from adult human ovaries [Last Updated On: February 27th, 2012] [Originally Added On: February 27th, 2012]
- 039 The Lancet Publishes Results from Gentium's Phase III Defibrotide Trial for the Prevention of VOD in Paediatric Patients [Last Updated On: February 28th, 2012] [Originally Added On: February 28th, 2012]
- 040 Egg-producing stem cells isolated from adult human ovaries [Last Updated On: February 28th, 2012] [Originally Added On: February 28th, 2012]
- 041 This is the only time bad breath is a good thing [Last Updated On: March 1st, 2012] [Originally Added On: March 1st, 2012]
- 042 BGI Demos Single-Cell Exome Sequencing Method on Tumor Cell Lines, Patient Samples [Last Updated On: March 7th, 2012] [Originally Added On: March 7th, 2012]
- 043 Cancer Paradigm Shift: Biomarker Links Clinical Outcome with New Model of Lethal Tumor Metabolism [Last Updated On: March 15th, 2012] [Originally Added On: March 15th, 2012]
- 044 NCCN Presents New Guidelines for Acute Lymphoblastic Leukemia [Last Updated On: March 21st, 2012] [Originally Added On: March 21st, 2012]
- 045 Bioheart Labs and Stemlogix Veterinary Products Featured in Media [Last Updated On: March 23rd, 2012] [Originally Added On: March 23rd, 2012]
- 046 ImmunoCellular Therapeutics to Present on Cancer Stem Cell Targeting at the AACR Annual Meeting [Last Updated On: March 27th, 2012] [Originally Added On: March 27th, 2012]
- 047 Are Cancer Stem Cells Ready for Prime Time? [Last Updated On: April 1st, 2012] [Originally Added On: April 1st, 2012]
- 048 Bacterin International Holdings, Inc. Schedules First Quarter 2012 Financial Earnings Conference Call [Last Updated On: April 25th, 2012] [Originally Added On: April 25th, 2012]
- 049 Apple to the Rescue [Last Updated On: April 25th, 2012] [Originally Added On: April 25th, 2012]
- 050 Bacterin Secures Accounts Receivable Credit Facility [Last Updated On: April 25th, 2012] [Originally Added On: April 25th, 2012]
- 051 Gentium Receives Day 180 List of Outstanding Issues From the CHMP for Defibrotide MAA [Last Updated On: May 4th, 2012] [Originally Added On: May 4th, 2012]
- 052 Stem cell shield may protect body from chemotherapy side effects [Last Updated On: May 11th, 2012] [Originally Added On: May 11th, 2012]
- 053 Gene-modified stem cell transplant protects patients from toxic side effects of chemotherapy [Last Updated On: May 11th, 2012] [Originally Added On: May 11th, 2012]
- 054 Gene-modified stem cell transplant protects patients from toxic side effects of chemotherapy, study suggests [Last Updated On: May 11th, 2012] [Originally Added On: May 11th, 2012]
- 055 Stem cell jab cuts chemo side effects [Last Updated On: May 11th, 2012] [Originally Added On: May 11th, 2012]
- 056 Boston scientists grow lung tissue from cystic fibrosis patients’ skin cells [Last Updated On: May 11th, 2012] [Originally Added On: May 11th, 2012]
- 057 New England Journal of Medicine Reports on Three Phase III REVLIMID® (lenalidomide) Trials in Patients with Newly ... [Last Updated On: May 11th, 2012] [Originally Added On: May 11th, 2012]
- 058 Transplanted Gene-Modified Blood Stem Cells Protect Brain Cancer Patients From Toxic Side Effects of Chemotherapy [Last Updated On: May 11th, 2012] [Originally Added On: May 11th, 2012]
- 059 Stem cells jab 'helps brain cancer patients tolerate chemotherapy' [Last Updated On: May 11th, 2012] [Originally Added On: May 11th, 2012]
- 060 'Cell shield' for cancer patients [Last Updated On: May 11th, 2012] [Originally Added On: May 11th, 2012]
- 061 Researchers find a way to delay aging of stem cells [Last Updated On: May 25th, 2012] [Originally Added On: May 25th, 2012]
- 062 Method to delay aging of stem cells developed [Last Updated On: May 25th, 2012] [Originally Added On: May 25th, 2012]
- 063 Verastem to Present Scientific Data at the 2012 ASCO Annual Meeting [Last Updated On: May 29th, 2012] [Originally Added On: May 29th, 2012]
- 064 Breast stem-cell research: Receptor teamwork is required and a new pathway may be involved [Last Updated On: May 31st, 2012] [Originally Added On: May 31st, 2012]
- 065 Breast stem cell research: Receptor teamwork required and a new pathway may be involved [Last Updated On: May 31st, 2012] [Originally Added On: May 31st, 2012]
- 066 This Week in Pathology [Last Updated On: June 1st, 2012] [Originally Added On: June 1st, 2012]
- 067 China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2012 [Last Updated On: June 12th, 2012] [Originally Added On: June 12th, 2012]
- 068 Cryo-Save Group N.V: Further cost savings with closure of France [Last Updated On: June 14th, 2012] [Originally Added On: June 14th, 2012]
- 069 Cell Therapeutics Appoints New Chief Medical Officer [Last Updated On: June 14th, 2012] [Originally Added On: June 14th, 2012]
- 070 Gentium Submits Day 180 Response to List of Outstanding Issues Received From the EMA's CHMP for Defibrotide MAA [Last Updated On: June 21st, 2012] [Originally Added On: June 21st, 2012]
- 071 Bioheart's Chief Science Officer Kristin Comella Presents at 10th Annual Meeting of International Society for Stem ... [Last Updated On: June 25th, 2012] [Originally Added On: June 25th, 2012]
- 072 Bioheart Announces New Brand Image, Launches Redesigned Website and New Company Logo [Last Updated On: June 27th, 2012] [Originally Added On: June 27th, 2012]
- 073 Bacterin Receives Letter From NYSE MKT LLC Regarding Timely Notice of Record Date for 2012 Annual Meeting of ... [Last Updated On: July 4th, 2012] [Originally Added On: July 4th, 2012]
- 074 Scientists Find New Way to Up Safety Factor of Stem Cell Therapy by Causing Contaminated Cells to Purge Themselves [Last Updated On: October 1st, 2012] [Originally Added On: October 1st, 2012]
- 075 Arlen Specter praised as fighter from a more moderate era [Last Updated On: October 15th, 2012] [Originally Added On: October 15th, 2012]
- 076 Nanodiamond coating for a better Petri dish [Last Updated On: October 16th, 2012] [Originally Added On: October 16th, 2012]
- 077 Bioheart Extends Licenses of Electrical Stimulation Patents With Airspeed [Last Updated On: October 18th, 2012] [Originally Added On: October 18th, 2012]
- 078 Stem Cells Therapy [Last Updated On: May 19th, 2015] [Originally Added On: May 19th, 2015]
- 079 Stem Cell Research - Stem Cell Treatments - Treatments ... [Last Updated On: May 19th, 2015] [Originally Added On: May 19th, 2015]
- 080 5. Hematopoietic Stem Cells [Stem Cell Information] [Last Updated On: May 24th, 2015] [Originally Added On: May 24th, 2015]