StemCell Therapy

High-throughput cell-based screening of drug library identifies albendazole as a sensitizer with combination of bortezomib for treatment multiple myeloma. [Kim MK, et al. Cancer Res 2014;74:1702 ]

A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells. [Thrane S, et al. Oncogene 2014;10.1038/onc.2014.351]

Patient-derived xenografts from non-small cell lung cancer brain metastases are valuable translational platforms for the development of personalized targeted therapy. [Lee HW, et al. Clin Cancer Res 2015;21(5):1172-82]

Kinome-level screening identifies inhibition of polo-like kinase-1 (PLK1) as a target for enhancing non-viral transgene expression. [Christensen MD, et al. J Control Release 2015;204:20-29]

Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway. [Bhardwaj V, et al. Oncotarget 2015;6(3):1531-43]

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer. [Franco J, et al. Oncotarget 2014;5(15):6512-25]

High-throughput Prescreening of Pharmaceuticals using a gGenome-wide bBacterial bBioreporter aArray. [Phillipson DW, et al. Biosensors and Bioelectronics 2015;68:699-704]

Overcoming acquired BRAF inhibitor resistance in melanoma via targeted inhibition of Hsp90 with ganetespib. [Acquaviva J, et al Mol Cancer Ther 2014;13(2):353-63]

Acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors. [Ember SW, et al ACS Chem Biol 2014;9(5):1160-71]

RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer. [Knudsen ES, et al. Cell Cycle 2015;14(1):109-22]

mTOR inhibition potentiates HSP90 inhibitor activity via cessation of HSP synthesis. [Acquaviva J, et al Mol Cancer Res 2014;12(5):703-13]

Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture. [de Wilde AH, et al. Antimicrob Agents Chemother 2014;58(8):4875-84]

Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery. [Ekins S, et al. PLoS Negl Trop Dis 2015;9(6):e0003878]

Aurora kinase A and B as new treatment targets in aromatase inhibitor-resistant breast cancer cells. [Hole S, et al. Breast Cancer Res Treat 2015;149(3):715-26]

Aurora kinases as druggable targets in pediatric leukemia: heterogeneity in target modulation activities and cytotoxicity by diverse novel therapeutic agents. [Jayanthan A, et al PLoS One 2014;9(7):e102741]

The Human Orphan Nuclear Receptor Tailless (TLX, NR2E1) Is Druggable. [Benod C, et al. PLoS One 2014;9(6):e99440]

Enhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian models. [Ekins S, et al. PLoS One 2013;8(5):e63240]

Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference. [Ansbro MR, et al. PLoS One 2013;8(4):e60334]

Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamoxifen resistant breast cancer. [Larsen SL, et al. BMC Cancer 2015;15:239]

Acetylation of intragenic histones on HPV16 correlates with enhanced HPV16 gene expression. [Johansson C, et al. Virology 2015;482:244-259]

Role of Kinase Epidermal Growth Factor Receptor and SRC in the Caerulein-Induced Acute Pancreatitis in Mice. [Huang Y, et al Pancreas 2014;10.1097/MPA.0219]

Synergistic apoptosis in head and neck squamous cell carcinoma cells by co-inhibition of insulin-like growth factor-1 receptor signaling and compensatory signaling pathways. [Axelrod MJ, et al Head Neck 2014;10.1002/hed.23822]

Pseudopeptides with a centrally positioned alkene-based disulphide bridge mimetic stimulate kallikrein-related peptidase 3 activity. [Meinander K, et al. MedChemComm 2013;4, 549-553]

Formation of covalently closed circular DNA in Hep38.7-Tet cells, a tetracycline inducible hepatitis B virus expression cell line. [Ogura N, et al Biochem Biophys Res Commun 2014;452(3):315-21]

Mass spectral similarity for untargeted metabolomics data analysis of complex mixtures. [Garg N, et al. International Journal of Mass Spectrometry 2014;10.1016/j.ijms.2014.06.005]

Bioinformatic mining of kinase inhibitors that regulate autophagy through kinase signaling pathways. [Yang Y, et al. Mol Med Rep 2014;10(6):3348-56]

From the biomolecular screening facility at the EPFL to the chemical biology screening platform for switzerland. [Turcatti G, et al. MedChemWatch 2013;Gerardo Turcatti]

Identification of kinases driving growth of anti-estrogen resistant T47D breast cancer cell lines. [Larsen SL, et al. Roskilde University 2013;Sarah Line Larsen ]

Selecting, acquiring, and using small molecule libraries for high-throughput screening. [Dandapani S, et al. Current Protocols in Chemical Biology 2012;4:177-191]

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Stem Cell Small Molecule Compound Library | Stem Cell ...

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