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Archive for the ‘Arthritis’ Category

Arthritis and the Cold Season – Business Daily

Thursday, July 9th, 2020

Health & FitnessSaturday, July 4, 2020 15:03

By DR FREDRICK OTIENO

Many patients with rheumatic diseases especially those presenting witharthritisreport increasing pain and stiffness during cold seasons.

Tales abound of how some patients can actually predict the onset of rain or cold weather from these symptoms. Whether it is a knee acting up when a rainstorm is on the horizon or, worse yet, a full-fledged rheumatoidarthritisflare when a blizzard hits, many of those with rheumatic diseases swear the weather harms their conditions.

The precise mechanism for this observation is not clearly understood, but it is thought that changes in weather can cause expansion and contraction of tendons, muscles, bones, and scar tissues, resulting in pain in the tissues that are affected byarthritis.

Low temperatures may also increase the thickness of joint fluids, making them stiffer and perhaps more sensitive to pain during movement.

What causes autoimmune diseases?

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Before addressing what precautions people living with rheumatic diseases can take during the rainy season, it is important to first understand what causes the condition. Anything foreign or toxic to our body are collectively called anti- gens; mostly some form of proteins or carbohydrate.

The immune system identifies these antigens and produces antibodies to get rid of them. Our cells, which are also made up of proteins and carbohydrates, escape the action of these soldiers due to the presence of specific distinguishing features called self-antigens. The immune cells, during their development in the thymus and bone marrow, are exposed to these self-antigens and made tolerant to them.

In a healthy individual, these tolerant cells go on to mature and become cells of the immune system. The body destroys the intolerant ones.

Many times, due to discrepancies in this process of destruction, the autoreactive immune cells escape the surveillance and can cause autoimmune disorders. These discrepancies can be genetic in origin, there could be a mutation in the self-antigens, or excessive and uncontrolled inflammation can lead to an overactive immune system.

Systemic autoimmune disorders occur when the effect of the autoreactive cells are seen all over the body, in conditions like lupus, rheumatoidarthritis, multiple sclerosis, and ankylosing spondylitis.

Arthritisis a common manifestation of most rheumatic diseases and is usually a result of inflammation.

Typical presentation includes:

What precautions can people living with rheumatic diseases take during the cold season?Patients with rheumatic diseases should be on effective treatment that ensures adequate disease control and suppression of inflammation at all times.

Treatments cannot cure autoimmune diseases, but they can control the overactive immune response and bring down inflammation or at least reduce pain and inflammation. These treatments include; non-steroidal anti-inflammatory drugs (NSAIDS), steroids, immunosuppressive drugs, and newer agents called biologic drugs.

Keeping warm: Dressing warmly, avoiding contact with cold water, take a warm shower, use hand gloves, warm bedding, and eat warm foods and beverages to reduce some of the effects seen when there is a drop in ambient temperature.

Exercise regularly: Exercise is crucial for patients living witharthritis. It is known to ease pain, increase strength and flexibility, and boost energy. The tendency during cold weather is for many people to shy off exercises. Patients should however prioritise exercise as this can ease the pain experience.

Dr Otieno is the assistant professor and consultant physician and rheumatologist at Aga Khan University Hospital, Nairobi.

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Skin problems, arthritis, reduced libido Why the body needs zinc and how to get it – The Saxon

Thursday, July 9th, 2020

Scientists believe that about 17% of people worldwide dont get enough zinc. This mineral is, however, very important, in particular, with the help of the body formed more than 300 different enzymes.

Who said that a lot of people, about 17% of the population experience zinc deficiency. Among the reasons for this called reducing consumption of animal food, the spread of diarrhoeal disorders and disorders of the intestine, chronic stress.

Zinc performs a very important function when its lack can even cause the fertility this mineral is essential for ovulation, the production of viable sperm, as well as to child bearing and lactation. But this is not all of its functions. Mineral helps preserve collagen in the skin and connective tissues, regulates the production of androgens, which in many cases are the cause of acne and other skin problems, it is involved in the synthesis of leukocytes, thyroid hormones, helps the body regulate the stress response.

Symptoms of zinc deficiency can be diverse, among them we can name:

In the body, zinc is not stored, so it must be regularly supplied in the diet. The daily menu should include seafood, poultry, beef, cocoa, egg yolk, whole seeds of flax, pumpkin and sesame seeds, wheat germ, lentils, almonds, peas, dairy products.

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Rheumatoid Arthritis Treatment Market Prognosticated For A Ravishing Growth By 2026 – Daily Research Chronicles

Thursday, July 9th, 2020

The strategy analysis on Global Rheumatoid Arthritis Treatment Market gives insights of market size, trends, share, growth, development plans, Investment Plan, cost structure and drivers analysis. With precise data covering all key aspects of the existing market, this report offers existing data of leading manufacturers. The Rheumatoid Arthritis Treatment market report covers marketing channels and market positioning to potential growth strategies, providing in-depth analysis for new competitors or exists competitors in the Rheumatoid Arthritis Treatment industry. The Report Gives Detail Analysis on Market concern Like Rheumatoid Arthritis Treatment Market share, CAGR Status, Market demand and up to date Market Trends with key Market segments. The report provides key statistics on the market status of the Rheumatoid Arthritis Treatment manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry. Overall, the report provides an in-depth insight of Rheumatoid Arthritis Treatment market covering all important parameters.

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The Rheumatoid Arthritis Treatment market was valued at XX Million US$ in 2019 and is projected to reach XX Million US$ by 2024, at a CAGR of XX% during the forecast period. In this study, 2019 has been considered as the base year and 2020 to 2024 as the forecast period to estimate the market size for Rheumatoid Arthritis Treatment.

Due to the pandemic, we have included a special section on the Impact of COVID 19 on the Rheumatoid Arthritis Treatment Market which would mention How the Covid-19 is Affecting the Rheumatoid Arthritis Treatment Industry, Market Trends and Potential Opportunities in the COVID-19 Landscape, Covid-19 Impact on Key Regions and Proposal for Rheumatoid Arthritis Treatment Players to fight Covid-19 Impact.

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The scope of the report is limited to the application of the type, and distribution channel. The regions considered in the scope of the report include North America Country (United States, Canada), South America, Asia Country (China, Japan, India, Korea), Europe Country (Germany, UK, France, Italy), Other Country (Middle East, Africa, GCC). This report presents the worldwide Rheumatoid Arthritis Treatment market size (value, production and consumption), splits the breakdown (data status 20152019 and forecast to 2024), by manufacturers, region, type and application.

Market segment by Type, the product can be split into:Product Type Segmentation: Epicel, IntegraIndustry Segmentation: Chemical, Cosmetic, Pharmaceutical

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Full in-depth analysis of the parent market Important changes in market dynamics Segmentation details of the market Former, on-going, and projected market analysis in terms of volume and value Assessment of niche industry developments Market share analysis Key strategies of major players Emerging segments and regional markets Testimonials to companies in order to fortify their foothold in the market.

Further, in the research report, the following points are included along with an in-depth study of each point:

* Production Analysis Production is analyzed with respect to different regions, types, and applications. Here, the price analysis of various Market key players is also covered.* Sales and Revenue Analysis Both, sales and revenue are studied for the different regions of the global market. Another major aspect, price, which plays an important part in the revenue generation is also assessed in this section for the various regions.* Supply and Consumption In continuation of sales, this section studies the supply and consumption of the Market. This part also sheds light on the gap between supply and consumption. Import and export figures are also given in this part.* Other analyses Apart from the information, trade and distribution analysis for the Market, contact information of major manufacturers, suppliers and key consumers are also given. Also, SWOT analysis for new projects and feasibility analysis for new investment are included.

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Reactive Arthritis Treatment Market to Expand at a Healthy CAGR of XX% Between and 2017 2027 Bulletin Line – Bulletin Line

Thursday, July 9th, 2020

The global Reactive Arthritis Treatment market gives detailed analysis about all the important aspects related to the market. The study on global Reactive Arthritis Treatment market, offers deep insights about the Reactive Arthritis Treatment market covering all the crucial aspects of the market. Moreover, the report provides historical information with future forecast over the forecast period. Various important factors such as market trends, revenue growth patterns market shares and demand and supply are included in almost all the market research report for every industry. Some of the important aspects analysed in the report includes market share, production, key regions, revenue rate as well as key players.

The study of various segments of the global market are also covered in the research report. In addition to that, for the forecast periods determination of factors like market size and the competitive landscape of the market is analysed in the report. Due to the increasing globalization and digitization, there are new trends coming to the market every day. The research report provides the in-depth analysis of all these trends.

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Key Players

Some of the players in reactive arthritis treatment market includes F. Hoffmann-La Roche Ltd, Teva Pharmaceutical Industries Ltd., Pfizer, Inc., Novartis AG, Amgen Inc., Velcura Therapeutics, Inc., Bayer AG, Geri-Care Pharmaceuticals, Merck Sharp & Dohme Corp, UCB S.A., Johnson & Johnson Services, Inc, Bristol-Myers Squibb Company, and AbbVie Inc., among others.

The report covers exhaustive analysis on:

The regional analysis includes:

North America (U.S., Canada)

Latin America (Mexico. Brazil)

Western Europe (Germany, Italy, France, U.K, Spain, Nordic countries, Belgium, Netherlands, Luxembourg)

Eastern Europe (Poland, Russia)

Asia-Pacific (China, India, ASEAN, Australia & New Zealand)

Japan

The Middle East and Africa (GCC, S. Africa, N. Africa)

The report is a compilation of first-hand information, qualitative and quantitative assessment by industry analysts, inputs from industry experts and industry participants across the value chain. The report provides in-depth analysis of parent market trends, macroeconomic indicators and governing factors along with market attractiveness as per segments. The report also maps the qualitative impact of various market factors on market segments and geographies.

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Detailed overview of parent market

Changing market dynamics in the industry

In-depth market segmentation

Historical, current and projected market size in terms of volume and value

Recent industry trends and developments

Competitive landscape

Strategies of key players and products offered

Potential and niche segments, geographical regions exhibiting promising growth

A neutral perspective on market performance

Must-have information for market players to sustain and enhance their market footprint.

NOTE All statements of fact, opinion, or analysis expressed in reports are those of the respective analysts. They do not necessarily reflect formal positions or views of Future Market Insights.

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No Association Between Clinical and Ultrasound Measures of Disease Activity in RA Remission – Rheumatology Advisor

Saturday, June 27th, 2020

Ultrasound abnormalities are widespread in patients with rheumatoid arthritis (RA) who are in clinical remission, with no significant association with clinical parameters in remission, according to study results published in Therapeutic Advances in Musculoskeletal Disease.

The study cohort included patients with an established diagnosis of RA who were enrolled in the Biomarkers of Remission in Rheumatoid Arthritis study, which evaluated disease-modifying antirheumatic drug (DMARD) cessation. Patients included this analysis were in clinical remission (Disease Activity Score 28 C-reactive protein [DAS28-CRP], <2.4) and receiving synthetic DMARDs at time of study entry. Patients from the Newcastle Early Arthritis Clinic who were DMARD-naive and undergoing clinical and ultrasonographic evaluation at first presentation with early active RA (DAS28-CRP >2.4) were included in the positive control group and those with seronegative noninflammatory arthralgia (NIA) were included in the negative control group.

Investigators examined the association between clinical parameters and total ultrasound scores with individual dependent variables, which included synovial power Doppler and greyscale, tenosynovial greyscale, and erosions.

Of 294 patients included in the study, 66 with RA were in clinical remission, 146 with early active RA were in the positive control group, and 82 were in the NIA negative control group. Synovial greyscale was common in patients in RA remission and occurred both in patients who did and did not meet the clinical remission criteria irrespective of whether it was the DAS28-CRP <2.4 (n=66) or the American College of Rheumatology/European League Against Rheumatism Boolean criteria (n=40). Other ultrasound abnormalities that occurred frequently included tenosynovial greyscale, erosions, and synovial power Doppler.

There was a significant association between swollen joint count and higher total synovial greyscale score (odds ratio [OR], 1.17; 95% CI, 1.08-1.26; P <.001) in the active RA group. In addition, the investigators observed a significant association between swollen joint count and higher total synovial power Doppler score (OR, 1.20; 95% CI, 1.12-1.30; P <.001). In the NIA group, there were no significant associations between swollen joint count and total synovial greyscale score or synovial power Doppler score. In the RA remission group, there were 6 significant variable-score associations (P <.05) in an adjusted model, but these associations were not significant in the adjusted analysis. In addition, there were no significant associations between the total synovial power Doppler score and clinical parameters in this group.

Study limitations included the reliance on a 7-point scan protocol, the small sample size, and the inclusion of only patients with established disease in the remission group.

Researchers concluded that ultrasound and clinical examination findings do not overlap in RA remission, challenging the proposition of ultrasound-driven management strategies in this setting.

Reference

Baker KF, Thompson B, Lendrem DW, Scadeng A, Pratt AG, Isaacs JD. Lack of association between clinical and ultrasound measures of disease activity in rheumatoid arthritis remission [published online May 11, 2020]. Ther Adv Musculoskelet Dis. doi:10.1177/1759720X20915322

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DECT Has Mixed Performance in Differentiating Gout vs CPPD – Medscape

Saturday, June 27th, 2020

Dual-energy computed tomography (DECT) appears to have limited utility for differentiating between gout and calcium pyrophosphate deposition disease (CPPD), according to a German prospective cohort study. Findings were reported at the annual European Congress of Rheumatology, held online this year because of COVID-19.

Dr Valentin S. Schfer

"Differentiation of gout and pseudogout, or CPPD, is sometimes difficult," said presenting investigator Valentin S. Schfer, MD, associate professor of internal medicine and head of the department of rheumatology and clinical immunology at University Hospital Bonn (Germany).

"Arthrocentesis and subsequent polarization microscopy remains the gold standard," he noted. "Novel diagnostic approaches, such as DECT, have recently been validated for gout, but limited data [are] available on the use of DECT in patients with CPPD."

The investigators studied 30 patients: 22 with suspected gout and 8 with suspected CPPD. All underwent arthrocentesis with subsequent polarization microscopy for definitive diagnosis, plus clinical examination, ultrasound examination, conventional radiography, DECT, and assessment of 12 laboratory parameters.

For diagnosis of gout, DECT had a sensitivity and specificity of 59.1% and 100%, respectively, Dr. Schfer reported, noting that this sensitivity falls considerably short of the 90% previously reported for gout (Figure 1).

Figure 1: Gout tophus formation (curved arrow) shown on 80-kV DECT with color-coded overlay showing monosodium urate crystals in green and calcium in blue, as well as articular and juxta-articular osseous erosions (straight arrow).

Corresponding sensitivity and specificity were 90.9% and 75% for ultrasound, 58.8% and 100% for conventional radiography, and 81.8% and 87.5% for the rheumatologists' suspected clinical diagnosis.

For diagnosis of CPPD, DECT had sensitivity of 37.5% and specificity of 81.8%. Corresponding values were 87.5% and 91% for ultrasound, 0% and 94.1% for conventional radiography, and 75.0% and 100% for suspected clinical diagnosis (Figure 2).

None of the 12 laboratory parameters studied uric acid, C-reactive protein, organic phosphate, and leukocytes, among others significantly differentiated between conditions.

Figure 2: DECT image with color-coded overlay shows typical findings of CPPD along the medial and lateral menisci (arrow) and calcium in tissues where it's not usually found (e.g., hyaline cartilage).

"Both ultrasound and suspected clinical diagnosis had higher sensitivities than DECT for gout and CPPD," Dr. Schfer concluded. "Further studies with larger patient cohorts and perhaps modified scan protocols are needed in order to determine the diagnostic utility of DECT in CPPD."

"Noninvasive, accurate methods for distinguishing between gout and CPPD will improve clinical care," Sara K. Tedeschi, MD, MPH, predicted in an interview.

"Arthrocentesis is painful in an acutely inflamed joint, can be difficult to perform on small joints, and is underutilized in clinical practice," she elaborated. And ultrasound is operator dependent and does not quantify crystal volume in and around the joint.

The question addressed by the study is therefore clinically relevant, according to Dr. Tedeschi, a rheumatologist at Brigham and Women's Hospital and assistant professor of medicine at Harvard Medical School, Boston.

However, among the patients with CPPD, the study did not report specific phenotypes (acute inflammatory arthritis, chronic inflammatory arthritis, and osteoarthritis with calcium pyrophosphate deposits), she noted. "It is difficult to draw conclusions about the sensitivity or specificity of DECT for CPPD without this information, especially among just 8 CPPD patients."

In addition, among the patients with gout, the proportion having new-onset disease with flare duration less than 6 weeks and the proportion with tophi were unknown, both of which affected DECT sensitivity in the previous study that reported 90% sensitivity. "Based on the 95% confidence interval in the present study, it is possible that with a larger sample size, DECT sensitivity for gout would have been higher," she pointed out. "We also do not know the DECT software settings, which impact DECT interpretation as positive or negative for the crystal of interest."

Finally, "it would be relevant to know what joints were aspirated and imaged in each group," Dr. Tedeschi said. "For example, if the first metatarsophalangeal (MTP) joint was aspirated and imaged for half of the gout patients but for none of the CPPD patients, that may affect the study interpretation."

The study did not receive any specific funding. Dr. Schfer disclosed a variety of financial relationships with multiple pharmaceutical companies. Dr. Tedeschi disclosed receiving grant support from the National Institutes of Health to study imaging modalities for CPPD, and being first author on a study comparing the sensitivity of DECT, ultrasound, and x-ray for acute CPP crystal arthritis.

Ann Rheum Dis. 2020;79:196. Abstract

This article originally appeared on MDedge.

For more news, follow Medscape on Facebook, Twitter, Instagram, and YouTube.

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Heres how to deal with one of the most dreaded injuries in golf – Golf.com

Saturday, June 27th, 2020

In the early part of the 2014 season, Jason Day missed six weeks with a thumb injury, which he aggravated at that years Masters tournament.

Getty Images

Arnold Palmer is famous for, among other things, his iconic thumbs up to adoring galleries. (Sorry, Phil.) I was lucky enough to call Arnold a good friend; in 2006, we launched the Arnold Palmer Sports Health Center. He had an abiding interest in keeping people healthy and participating in the game he loved.

The thumb is remarkable, and we ask much of it. Gripping a golf club throughout the swing means positioning the thumb at multiple points in space, and that demands great flexibility. This flexibility is provided by two hinge joints and the very agile basilar joint where the thumb plugs into your wrist plus great strength and stability.

This balancing act can create a problem that manifests as friction at the basilar jointaka arthritis. Almost all golfers will eventually get a little degenerative wear and tear arthritis at the thumb joint. Ive operated on several PGA Tour Champions players, but most of us will have milder cases treatable by conservative measures.

Symptoms: Pain and modest swelling at the thumbs base is common; more advanced cases may lead to a decrease in motion. Your hand may feel weakened as discomfort can lead to protecting the thumb from tasks (e.g., opening jars) in which grip power is necessary and potentially painful.

Self-Care: There is a wide range of nonsurgical managementsice, heat, splints and judicious use of over-the-counter anti-inflammatories. Any splint used should include the thumb to help support the basilar joint.

Doctor Visit: A diagnosis will likely entail the doctor loading the thumbs basilar joint and briefly grinding it you may feel the discomfort and mechanical symptoms that accompany joint irregularity. An X-ray can help establish matters definitively. As for treatment beyond splinting and activity modification, a steroid shot can bring temporary relief. As a last resort, a reliable surgery can be performed that allows you to participate in most activities without restriction including golf. Thumbs up to that!

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COVID-19 Treatment Developed In St. Louis To Begin Human Trials – St. Louis Public Radio

Saturday, June 27th, 2020

COVID-19 remains a mystery in many ways, but as it continues to rampage through the worlds population, some things are becoming more clear. One of them is that cytokine storms a deranged immune response to the virus, in which the body literally attacks its own cells instead of the invading coronavirus appear to be one reason some patients end up extremely ill.

A drug developed in St. Louis aims to combat those cytokine storms. Called ATI-450, it was originally developed by Confluence Discovery Technologies in 2013 with the idea of helping people suffering from autoimmune diseases, particularly rheumatoid arthritis.

But as scientists began to understand the way COVID-19 affects the body, the company realized it could potentially help with the new coronavirus as well.

Were actually in a Phase 2 rheumatoid arthritis study, explained Joe Monahan, Confluence Discovery Technologies executive vice president of research and development, on St. Louis on the Air. That started earlier in the year. But when we saw what was happening with COVID back in January or February, and we started to think about the possibility of both COVID being driven by the cytokine storm in the lung, and [rheumatoid arthritis] being driven by a similar storm of cytokines regulated in the joint, we thought maybe we could do some quick studies in the laboratory to validate that ATI-450 may have an impact on these cytokines in the lung, and in particular things driven by the SARS CoV-2.

Added Monahan, It was the right place at the right time.

And so even as most businesses around St. Louis closed their offices and moved to remote work this spring, Confluence doubled down. With staggered shifts and seven-day workweeks, researchers in its headquarters at Cortexs BioSTL building were able to show strong enough results in the lab to receive FDA approval to begin human trials.

Those are to begin in two weeks at the University of Kansas Medical Center, Monahan said. Thirty-six patients will be given the drug in a double-blind, placebo-controlled study.

The company hopes to show that, by blocking the pathways used to make cytokines, ATI-450 stops the cytokine storms that can be so damaging. Explained Monahan, In so doing, we believe that we would reduce the [acute respiratory distress syndrome] observed in these patients, and reduce the need for mechanical ventilation, decrease the hospital stay, and reduce the mortality.

Listen:

Normally, good results in such a study would mean another three to six years before bringing a drug to market. But Monahan has hopes for a speedier process for ATI-450 when it comes to COVID-19.

If this works really well [against] the disease, and we expand it to more people and it continues to work, I think theres an ability to really shorten those timelines, he said.

Confluence was acquired by Pennsylvania-based Aclaris Therapeutics in 2017, but its researchers remain based in St. Louis. Monahan helped to co-found the company as part of BioSTL after spending 28 years at Pfizer and its legacy companies. The pharmaceutical giant was moving a unit to the Boston area, and rather than relocate, Monahan and some colleagues decided to stay in St. Louis and go out on their own.

We had maybe some different ideas on how to do drug discoveries that we had not been able to do at Pfizer, he said.

St. Louis on the Air brings you the stories of St. Louis and the people who live, work and create in our region. The show is hosted by Sarah Fenske and produced by Alex Heuer, Emily Woodbury, Evie Hemphill, and Lara Hamdan. The audio engineer is Aaron Doerr.

Send questions and comments about this story to feedback@stlpublicradio.org.

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Lyme disease emerged in Connecticut in the 1970s … then the conspiracy theories started – Connecticut Magazine

Saturday, June 27th, 2020

Sciepro / Science Photo Library / Getty Images

At first no one believed the mom from Lyme. Polly Murray moved with her family to the Connecticut River town in the late 1950s and within a few years began experiencing mysterious symptoms. There were rashes, migraines, recurring fevers, and severe joint pain including a swollen knee. Over the years her children and even the family dog had similar ailments. Doctors believed it was all in her head, and she agreed to a psychiatrists suggestion to obtain three weeks of inpatient treatment.

By 1975 her two sons were diagnosed with juvenile rheumatoid arthritis, but neighbors had children with similar ailments, and Murray, who died last year, didnt believe the occurrences of this rare condition in children were a coincidence. Murray and another mother reached out to the state Health Department and the Yale School of Medicine.

A few months earlier, a 33-year-old doctor named Allen Steere had started a fellowship in rheumatology at Yale School of Medicine. Steere had spent the previous two years investigating disease outbreaks as an epidemic intelligence officer with the Centers for Disease Control in Atlanta. State officials thought he would be the ideal person to investigate these cases. Steere asked Dr. Stephen Malawista, who headed the rheumatology program at the Yale School of Medicine, for permission to start.

He said, Fine, why dont you take six months and see what you can do? Its now 45 years later, and I and lots of other people are still working on this, Steere says.

Steere, now a professor of medicine at Harvard Medical School and director of translational research in rheumatology at Massachusetts General Hospital, began contacting parents who had children with joint pain, particularly knee pain. Consulting with school nurses in Lyme and surrounding communities, Steere identified 39 children and 12 adults with this unexplained rheumatoid arthritis in Lyme,as well as neighboring Old Lyme and East Haddam. It was clear that they had inflammatory arthritis, he says, but the condition was occurring far too frequently in the area, particularly in children. If you had one child in that Lyme, Connecticut, area that had inflammatory arthritis, maybe thats what youd expect, but not 39. Moreover, there was clustering within certain areas. There were a couple of roads where 1 in 10 children had this type of inflammatory arthritis.

It was apparent that this was something different than had been seen before and described in the medical literature, and we began to call it Lyme arthritis, Steere adds.

Through contact tracing, Steere learned that most cases had occurred in the summer and early fall, and there was no evidence of person-to-person spread. Twenty-five percent of the patients remembered having a strange skin lesion shortly before they developed symptoms. Around the same time, Steere learned from a Danish dermatology resident at Yale that a similar skin lesion called erythema migrans had been known in Europe for years and was caused by a tick bite.

Residents told Steere that as recently as the 1960s there were no ticks, but that the area had been inundated with them by the 1970s. This was due to massive swaths of farmland being converted back to forests, which supported tick and wildlife habitats. By 1976 Steere and his fellow researchers put forth the belief that ticks were responsible for spreading the infection. In 1981 a researcher at the Rocky Mountain Biological Laboratory named Willy Burgdorfer identified the bacteria that causes Lyme. Meanwhile, Steere helped to research early antibiotic treatments for the disease.

Though Lyme emerged from the wilds in Connecticut in and around the 1970s, it was not a new disease, Steere says. There are descriptions of what sounds like Lyme disease in writings from the 1600s and confirmed cases of the disease found in preserved specimens in New England and Europe from the 1800s. The 2010 autopsy of tzi the Iceman, a 5,300-year-old frozen mummy found in the Eastern Alps in the 1990s, revealed he had Lyme disease.

Despite this historical evidence of the condition, conspiracy theories as to its origins are rampant. The most prominent holds that it was a biological warfare agent developed at Plum Island Animal Disease Center, a federal island research facility dedicated to the study of animal diseases 8 miles off the Connecticut coast. Between 1952 and 1954, the island also served as the headquarters for the Army Chemical Corps. The corps hoped to study biological weapons, but according to credible accounts, never truly pursued its work on the island. In addition, Lyme-like conditions were never studied at the island, and there would be records if they were, as the work that takes place on the island is not classified. In addition, tick specimens from 1945 from the South Fork of Long Island were also found to contain the disease, several years before the island facility opened in the 1950s.

Back in the 1970s, Steere says, I knew nothing about Plum Island and nobody thought that Plum Island had anything to do with this. He adds that it wasnt until many years later that he first started hearing conspiracy theories linking Lyme disease to Plum Island.

Jane Marsh, a lifelong Old Lyme resident, recalls her father being one of the first adults to get the disease. Marsh later got the disease, as did everyone in her family. We did not suspect that anything came floating across from there to Old Lyme, she says. She got wind of the conspiracy theory later and, though she never bought into it, Marsh says she knows people in the area who believe it.

The theory has also stretched beyond Connecticut. Last year New Jersey Rep. Chris Smith called for an investigation into whether the Department of Defense experimented with ticks and other insects to deliver biological weapons between 1950 and 1970.

Plum Island isnt the only controversy associated with Lyme disease. Chronic Lyme is a condition many patients believe they have but which the Centers for Disease Control does not recognize, and which Steere has said is overdiagnosed.

Lyme disease is a complex infection, there are no two ways about it, Steere says. Its an illness that without treatment can occur in stages with different manifestations at each stage. People can have neurologic involvement, they can have cardiac involvement, they can have arthritis. But it does not cause everything. There are advocacy groups that have grown up that attribute a much wider spectrum of illness to Lyme disease than is the case in mainstream medicine.

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Lyme disease emerged in Connecticut in the 1970s ... then the conspiracy theories started - Connecticut Magazine

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US Scientists Begin Phase 3 Trial of Arthritis Drug to Study its Effect on COVID-19 – The Weather Channel

Wednesday, June 24th, 2020

Representational Image of Medicine

Researchers at the University of Texas Health Science Center at Houston (UTHealth) in the US are studying the effectiveness of an arthritis drug in treating a type of severe immune overreaction seen in patients with COVID-19 induced pneumonia in Phase 3 clinical trial.

The clinical trial is enrolling patients at the Harris Health System's Lyndon B. Johnson Hospital in Houston, Texas. The Phase 3 study is evaluating the effectiveness of the drug canakinumab, an interleukin-1 (IL-1) blocker approved for the treatment of juvenile rheumatoid arthritis, for preventing cytokine release syndrome (CRS) in COVID-19 patients with pneumonia.

Often referred to as a cytokine storm, CRS is a life-threatening immune reaction caused by the body releasing too many cytokines into the blood at once. Cytokines include a broad category of proteins secreted by the body.

Interleukin-1 serves as the first-line defence for the immune system, alerting other proteins to respond if a virus or bacteria are present. Canakinumab blocks the production of IL-1 protein, which could prevent a possible deadly overreaction of the immune system in COVID-19 patients.

Research has linked a number of COVID-19 deaths to CRS due to damage caused to several major organs.

Roberto C. Arduino, MD, the study's lead investigator and professor of infectious disease at the McGovern Medical School in UTHealth, said this is a time for the HIV research community to utilise the members' expertise in the search for a treatment for coronavirus.

Arduino's research background includes the study of new antiretroviral drugs, treatment strategies, immune activation, and inflammation in the search for an HIV cure.

"The research community truly feels compelled to do something in the search for a viable treatment for COVID-19, and I feel I owe it to my community to offer my expertise," said Arduino, who has led HIV clinical research for 22 years.

Researchers are investigating if canakinumab combined with standard-of-care treatment can increase the chances of survival without ever requiring invasive mechanical ventilation in patients with COVID-19-induced pneumonia.

Over a two-hour period, patients who are enrolled will receive either a 450 mg, 600 mg, or a 750 mg IV dose of canakinumab based on their body weight, UTHealth said in a statement on Monday. Arduino is the study's lead investigator. All participants will be monitored for up to 29 days, or until they are discharged from the hospital. A follow-up will occur at 127 days.

The Weather Companys primary journalistic mission is to report on breaking weather news, the environment and the importance of science to our lives. This story does not necessarily represent the position of our parent company, IBM.

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Survey launched on impact of Covid-19 on people with arthritis – TipperaryLive.ie

Wednesday, June 24th, 2020

Arthritis Ireland has launched a nationwide survey asking people with arthritis to share their experiences of Covid-19. The survey is available online and takes 10-15 mins to complete.

Nearly one million people are living with arthritis in Ireland; many of whom have been severely impacted by the pandemic; for example, due to being immunosuppressed or aged over 70.

The survey includes questions on how the pandemic affected peoples physical and mental health, their access to health services, where they sourced information about the coronavirus, and how their employment and personal finances have been impacted.

Brian Lynch, head of communications and advocacy, said: This research will give us direct insights into how Covid-19 has impacted people living with arthritis. This is a diverse population, but some were extremely medically vulnerable, many were required to cocoon, people had appointments postponed or cancelled. Arthritis is a chronic condition for which there is yet no cure; peoples symptoms, their pain and fatigue didnt disappear during the pandemic.

Lynch said that when they analyse the information, it will help the patient organisation advocate for better services and access to healthcare.

Arthritis is the single biggest cause of disability in Ireland, resulting in significant loss of physical health and function. Inflammatory forms of arthritis are systemic diseases which can affect your whole body. Its vital that our rheumatology service be resourced and structured to best meet the needs of new and existing patients, he said.

At the end of May there were 18,818 people waiting for a rheumatology appointment; 44% of whom were waiting longer than 12 months. There were 68,463 waiting for an appointment with an orthopaedic consultant; 38% of whom were waiting longer than 12 months.

The survey can be accessed via the Arthritis Ireland website,www.arthritisireland.ie.

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COVID-19 Impact and Recovery Solutions on Rheumatoid Arthritis and Lupus Treatments Market- Business Growth Strategies by Key Players: AbbVie, Amgen,…

Wednesday, June 24th, 2020

Synopsis of Global Rheumatoid Arthritis and Lupus Treatments Market Report:

The Rheumatoid Arthritis and Lupus Treatments Market complete overview of the market, covering various aspects product definition, segmentation based on various parameters, and the prevailing market landscape. The report provides a distinct point-of-view through analysing market scenarios to comparative pricing between major players, cost and profit of the specified market regions.

Furthermore, the development of policies and plans as well as manufacturing processes are mentioned to assist in the decision making process. The report also states import/export consumption, supply and demand Figures, cost, price, revenue and gross margins to justify the stated forecast. To provide an accurate forecast aspects such as regional demand & supply factors, recent investments, market dynamics including technical growth scenario, consumer behavior, and end use trends and dynamics, and production capacity have also been thoroughly studied.

Have some queries? Get Free Sample PDF Copy based on Latest Research on Rheumatoid Arthritis and Lupus Treatments Market after the Covid-19 impact: https://www.acquiremarketresearch.com/sample-request/360571/

The report provides a granular analysis of the market share, segmentation, revenue forecasts and geographic regions of the market. Following are some of the segmentations provided in the report ;

Leading players operating in the global Rheumatoid Arthritis and Lupus Treatments market are: AbbVie, Amgen, Bayer, Biogen Idec, Roche, Johnson and Johnson, Merck, Mitsubishi Tanabe Pharma, Novartis, Pfizer

Rheumatoid Arthritis and Lupus Treatments Market Growth by Types: Rheumatoid Arthritis Treatments, Lupus Treatments

Rheumatoid Arthritis and Lupus Treatments Market Extension by Applications: Hospitals and Clinics, Ambulatory Surgery Centers, Homecare Settings

The Global version of this report with a geographical classification would cover regions: North America (USA, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, Colombia etc.), Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria, and South Africa)

Report on Rheumatoid Arthritis and Lupus Treatments Market (covering Covid-19 impacts) at an Impressive Discount! With Corporate Email ID @ https://www.acquiremarketresearch.com/discount-request/360571/

While segmentations have been provided to list down various facets of the Rheumatoid Arthritis and Lupus Treatments market, analysis methods such as S.T.E.E.P.L.E., S.W.O.T., Regression analysis, etc. have been utilized to study the underlying factors of the market. Summarization of various aspects consisted in the report have been listed.

What does this research exactly offer?1.The Rheumatoid Arthritis and Lupus Treatments market shares of every equatorial region as well as market share for every product type with the growth rate for the forecast period has been provided.2.The revenue in terms of valuation and percentage at the end of the forecast period has been well explained with the help of a number of tables and charts.3.The study also includes market share for every separate domain of the Rheumatoid Arthritis and Lupus Treatments market from the beginning of the forecast year to the end of the forecast period.4.The Rheumatoid Arthritis and Lupus Treatments study also encompasses a separate section that included data pertaining to certain important aspects of the market such as vital parameters such as industry chain analysis and analysis of the upstream market and many more.5.Additionally, the report will also include an evaluation of the distribution of the consumer base with a percentage base of which domain will be occupying the most market share during and after the forecast base.

Covid-19 virus has vastly transformed the market and has shaken its position such that it is up for grabs. We at Acquire Market Research help you to achieve your desired market position. While its our primary concern we also provide necessary information regarding the Covid-19 virus and necessary step to stay safe.

Critical doubts Related to Rheumatoid Arthritis and Lupus Treatments Market addressed in the report; What is the CAGR of Rheumatoid Arthritis and Lupus Treatments Market after the effects of Covid-19?What is the current status of markets, with respect to the Rheumatoid Arthritis and Lupus Treatments Market and who are the market leaders?After dispersion of markets, are there any new entrants in the market who are capturing customers at an exponential rate?Competitive strategies of market leaders and their future plans to capture markets?Effects of Covid-19 on the large markets and potential markets of the Rheumatoid Arthritis and Lupus Treatments Market.

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COVID-19 Impact and Recovery Solutions on Rheumatoid Arthritis and Lupus Treatments Market- Business Growth Strategies by Key Players: AbbVie, Amgen,...

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Blood Thinner Could Prevent Osteoarthritis – Rheumatology Network

Wednesday, June 24th, 2020

Researchers writing in the current issue of Arthritis and Rheumatology report that a blood thinner may have potential as a preventive treatment for osteoarthritis.

Ticagrelor (Brilinta, AstraZeneca) is a P2Y12 platelet inhibitor currently used to prevent stroke and heart attack in patients with acute coronary syndrome or a history of myocardial infarction. It works by increasing the presence of extracellular adenosine which, in turn, regulates the inflammatory processes. Studies in animal models have shown that it is effective in treating osteoarthritis.

In this study, researchers compared the results in patients who were treated with ticagrelor and a second group who was treated with the blood thinner clopidogrel, which does not increase extracellular adenosine concentrations. This was a five-year study that included 7,007 patients who were treated with ticagrelor for an average of 287 days and 14,014 were treated with clopidogrel for an average of 284 days. The study excluded patients with an osteoarthritis diagnosis at baseline. The average patient was 64 years old and most, at 73 percent, were male. Researchers concluded that patients who were treated with ticagrelor had a 29 percent reduced risk of osteoarthritis (estimated a hazard ratio of 0.71 (95% CI 0.64-0.79, p<0.001).

These findings suggest that extracellular adenosine may play an important role in reducing cartilage inflammation and damage, and that it might serve as a therapeutic target for preventing and treating osteoarthritis in humans, wrote researchers who were led by Matthew C. Baker, M.D., of Stanford University. We believe that even this relatively short treatment period may provide protection against developing osteoarthritis over the subsequent years. It is not clear how long this effect may last, as the follow-up period for this study ended at five years, with a relatively small number of patients at risk after three years.

Osteoarthritis affects about 27 million adults in the United States. It was once thought of merely as degeneration of the joints, but today is more often recognized as a disease driven by low-grade inflammation and complex interactions between genes and the environment, Dr. Baker and colleagues wrote. There are no effective treatments to prevent the onset or progression of osteoarthritis, and novel therapies are needed.

REFERENCE

Matthew C. Baker, Yingjie Weng, Robinson H. William, Neera Ahuja, Nidhi Rohatgi. Osteoarthritis risk is reduced after treatment with ticagrelor compared to clopidogrel: a propensity score matching analysis, Arthritis and Rheumatology. First Published: 21 June 2020

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Lyme disease emerged in CT in the 1970s … then the conspiracy theories started – CT Insider

Wednesday, June 24th, 2020

At first no one believed the mom from Lyme. Polly Murray moved with her family to the Connecticut River town in the late 1950s and within a few years began experiencing mysterious symptoms. There were rashes, migraines, recurring fevers, and severe joint pain including a swollen knee. Over the years her children and even the family dog had similar ailments. Doctors believed it was all in her head, and she agreed to a psychiatrists suggestion to obtain three weeks of inpatient treatment.

By 1975 her two sons were diagnosed with juvenile rheumatoid arthritis, but neighbors had children with similar ailments, and Murray, who died last year, didnt believe the occurrences of this rare condition in children were a coincidence. Murray and another mother reached out to the state Health Department and the Yale School of Medicine.

A few months earlier, a 33-year-old doctor named Allen Steere had started a fellowship in rheumatology at Yale School of Medicine. Steere had spent the previous two years investigating disease outbreaks as an epidemic intelligence officer with the Centers for Disease Control in Atlanta. State officials thought he would be the ideal person to investigate these cases. Steere asked Dr. Stephen Malawista, who headed the rheumatology program at the Yale School of Medicine, for permission to start.

He said, Fine, why dont you take six months and see what you can do? Its now 45 years later, and I and lots of other people are still working on this, Steere says.

Steere, now a professor of medicine at Harvard Medical School and director of translational research in rheumatology at Massachusetts General Hospital, began contacting parents who had children with joint pain, particularly knee pain. Consulting with school nurses in Lyme and surrounding communities, Steere identified 39 children and 12 adults with this unexplained rheumatoid arthritis in Lyme, as well as neighboring Old Lyme and East Haddam.

It was clear that they had inflammatory arthritis, he says, but the condition was occurring far too frequently in the area, particularly in children. If you had one child in that Lyme, Connecticut, area that had inflammatory arthritis, maybe thats what youd expect, but not 39. Moreover, there was clustering within certain areas. There were a couple of roads where 1 in 10 children had this type of inflammatory arthritis.

It was apparent that this was something different than had been seen before and described in the medical literature, and we began to call it Lyme arthritis, Steere adds.

Through contact tracing, Steere learned that most cases had occurred in the summer and early fall, and there was no evidence of person-to-person spread. Twenty-five percent of the patients remembered having a strange skin lesion shortly before they developed symptoms. Around the same time, Steere learned from a Danish dermatology resident at Yale that a similar skin lesion called erythema migrans had been known in Europe for years and was caused by a tick bite.

Residents told Steere that as recently as the 1960s there were no ticks, but that the area had been inundated with them by the 1970s. This was due to massive swaths of farmland being converted back to forests, which supported tick and wildlife habitats. By 1976 Steere and his fellow researchers put forth the belief that ticks were responsible for spreading the infection. In 1981 a researcher at the Rocky Mountain Biological Laboratory named Willy Burgdorfer identified the bacteria that causes Lyme. Meanwhile, Steere helped to research early antibiotic treatments for the disease.

Though Lyme emerged from the wilds in Connecticut in and around the 1970s, it was not a new disease, Steere says. There are descriptions of what sounds like Lyme disease in writings from the 1600s and confirmed cases of the disease found in preserved specimens in New England and Europe from the 1800s. The 2010 autopsy of tzi the Iceman, a 5,300-year-old frozen mummy found in the Eastern Alps in the 1990s, revealed he had Lyme disease.

Despite this historical evidence of the condition, conspiracy theories as to its origins are rampant. The most prominent holds that it was a biological warfare agent developed at Plum Island Animal Disease Center, a federal island research facility dedicated to the study of animal diseases 8 miles off the Connecticut coast. Between 1952 and 1954, the island also served as the headquarters for the Army Chemical Corps. The corps hoped to study biological weapons, but according to credible accounts, never truly pursued its work on the island. In addition, Lyme-like conditions were never studied at the island, and there would be records if they were, as the work that takes place on the island is not classified. In addition, tick specimens from 1945 from the South Fork of Long Island were also found to contain the disease, several years before the island facility opened in the 1950s.

Back in the 1970s, Steere says, I knew nothing about Plum Island and nobody thought that Plum Island had anything to do with this. He adds that it wasnt until many years later that he first started hearing conspiracy theories linking Lyme disease to Plum Island.

Jane Marsh, a lifelong Old Lyme resident, recalls her father being one of the first adults to get the disease. Marsh later got the disease, as did everyone in her family. We did not suspect that anything came floating across from there to Old Lyme, she says. She got wind of the conspiracy theory later and, though she never bought into it, Marsh says she knows people in the area who believe it.

The theory has also stretched beyond Connecticut. Last year New Jersey Rep. Chris Smith called for an investigation into whether the Department of Defense experimented with ticks and other insects to deliver biological weapons between 1950 and 1970.

Plum Island isnt the only controversy associated with Lyme disease. Chronic Lyme is a condition many patients believe they have but which the Centers for Disease Control does not recognize, and which Steere has said is overdiagnosed.

Lyme disease is a complex infection, there are no two ways about it, Steere says. Its an illness that without treatment can occur in stages with different manifestations at each stage. People can have neurologic involvement, they can have cardiac involvement, they can have arthritis. But it does not cause everything. There are advocacy groups that have grown up that attribute a much wider spectrum of illness to Lyme disease than is the case in mainstream medicine.

This article originally appeared in Connecticut Magazine. You can subscribe here , or find the current issue on sale here . Sign up for the newsletter to get the latest and greatest content from Connecticut Magazine delivered right to your inbox. On Facebook and Instagram @connecticutmagazine and Twitter @connecticutmag .

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Lyme disease emerged in CT in the 1970s ... then the conspiracy theories started - CT Insider

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Arthritis pain – the cheap snack you should add to your shopping list to avoid symptoms – Express.co.uk

Tuesday, June 23rd, 2020

Arthritis pain can lead to a number of debilitating symptoms that patients will want to try and avoid.

The condition can make life more difficult when carrying out simply, everyday tasks.

But, just some simple lifestyle changes could go a long way in helping to prevent arthritis symptoms from flaring up.

One of the best ways to avoid triggering arthritis symptoms is to eat more nuts, it's been revealed.

READ MORE: Arthritis warning - the common vegetable you should avoid

"Certain foods can actually help to ease arthritis symptoms and improve your overall joint health," said Penn Medicine.

"Along with the use of medications, a proper diet can curb the inflammatory responses from the body that cause pain.

"Almonds, hazelnuts, peanuts, pecans, pistachios and walnuts contain high amounts of fibre, calcium, magnesium, zinc, Vitamin E and Omega-3 fats which all have anti-inflammatory effects.

"Nuts are also heart-healthy, which is particularly important for people with rheumatoid arthritis, since they have twice the risk of heart disease as healthy adults."

Common arthritis symptoms include joint pain, inflammation, and restricted movement.

There are two key types of arthritis in the UK; osteoarthritis and rheumatoid arthritis.

Osteoarthritis is the most common type of arthritis to be diagnosed in the UK - around nine million people are believed to have osteoarthritis.

Rheumatoid arthritis, meanwhile, is an auto-immune disease that has been diagnosed in about 400,000 individuals.

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Arthritis pain - the cheap snack you should add to your shopping list to avoid symptoms - Express.co.uk

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The Ultimate Guide to CBD and Seniors With Arthritis – Cleveland Scene

Tuesday, June 23rd, 2020

This article was originally published on CBD Seniors. To view the original article, click here.

In the United States, 23 percent of adults suffer from arthritis. Around the world, 350 million people have this condition. While most people who have arthritis are age 65 or older, there are still many young and middle-aged adults who also have this condition.

Unfortunately, there is no known cure for arthritis. The best thing that scientists can currently do for the condition is alleviate the symptoms and slow down the progression of the disease. By reducing the bodys inflammatory response, doctors can help you live in less pain for longer. While every drug carries some risks and side effects, cannabidiol (CBD) is showing promise as a way to treat the pain of arthritis and reduce the progression of the disease. How Does CBD Help?

Thanks to the passage of the 2018 Farm Bill, farmers can now grow and process hemp in the United States. Because of this, CBD is now widely available online for people across the country. In addition to helping with conditions like insomnia and anxiety, research also shows that CBD can help alleviate pain as well.

CBD is a chemical compound that is naturally found within cannabis plants. While this compound will not make you high, it does have other useful benefits. Since cannabis was completely illegal until very recently, scientists are still working to understand the effects of using cannabis. CBD is only one out of dozens of different cannabinoids in cannabis, so other cannabinoids may have additional effects as well.

In the United States, people can readily buy CBD balm, tinctures, vaporizers and gummies. One study by Harris Poll found that 85 percent of Americans have already heard about CBD. Out of these adults, more than 20 percent have actually tried it.

Once CBD is extracted from cannabis, it can be used to treat ailments ranging from anxiety to chronic stress. CBD works by targeting receptors in the endogenous cannabinoid system. The cannabinoid system consists of neurotransmitters that naturally bind to cannabinoid receptors. These cannabinoid receptor proteins are naturally made in the human body. CBD targets the same receptors in order to alleviate pain, anxiety and stress.

Currently, about 55 percent of users state that they take CBD in order to relax.An estimated half of people use CBD for anxiety and stress. The next most common reason why people used CBD was for pain. In addition, some people use CBD for menstrual symptoms, migraines, nausea and sexual enhancement.

What Does the Research Say?

Because CBD was illegal like the rest of the cannabis plant, researchers are still trying to gain a better understanding of how effective this drug is for various conditions. In addition, researchers still need to figure out effective dosages. In rats, moderate doses of CBD have been shown to produce an anti-anxiety effect.

Another rat study shows that oral and topical solutions of CBD can help to alleviate pain. This particular study involved scientists exposing the rats sciatic nerves using an incision. Then, they constricted the nerves. Another part of the study involved injecting bacteria into the rats paws to cause inflammation. Afterward, the scientists gave the rats CBD or a placebo for a week. They applied pressure or heat to the rats legs to see how their reaction changed in comparison to their pre-study reactions. The rats that received CBD had less pain than the control group.

In a 2010 study of human patients, 177 people experiencing cancer-related pain were given extracts of tetrahydrocannabinol (THC) and CBD. The patients who received extracts with THC and CBD were twice as likely to experience pain relief as the patients who received just THC. This seems to indicate that CBD alone or the combination of the two is the component that leads to pain relief.

Related: Looking for reliable CBD products backed by lab-test results? Check out RealTestedCBD.

CBD and Arthritis Pain

An estimated 54 million Americans suffer from arthritis. Out of this number, 24 million Americans have to limit their daily activities because of arthritis. While people may say they just have arthritis, arthritis is actually a term that covers more than 100 different conditions. All of these conditions involve some level of swelling, pain and stiffness. With certain kinds of arthritis, the organs can also be affected.

The most common type of arthritis is osteoarthritis. This is the form that causes cartilage to deteriorate. Since this cartilage helps to protect your bones from friction, it can lead to pain and joint damage. People who experience this condition can develop inflammation as well. Because it takes time for cartilage to deteriorate, this condition typically affects the elderly more than it affects young adults.

Inflammatory arthritis like psoriatic and rheumatoid arthritis are connected to autoimmune conditions. These kinds of conditions develop because the immune system thinks that it is under attack from invaders. Instead of attacking invading viruses, the body attacks organs or bones. This leads to severe pain and inflammation.

Once someone experiences joint deterioration, the symptoms tend to get worse over time. Other than treating joint and nerve pain, many patients also need help with inflammation. By using CBD, you might be able to limit your joint pain, inflammation and mobility issues. Arthritis symptoms like stiffness, decreased joint movement and pain tend to respond well to CBD.

How the Endocannabinoid System Works

The endocannabinoid system is a fairly recent discovery. It was discovered after researchers started learning about the way cannabis affects the body, which is how this system got its name. People have used cannabis for therapeutic purposes for centuries. In 1964, researchers finally managed to isolate THC. Amazingly, this was the first time scientists learned how cannabis made people high.

Out of all of the cannabinoids, THC is the most abundant in the plant. THC affects neuronal signaling in the body. During the 1990s, researchers found different cannabinoid receptors in the body. Researchers discovered that THC binds with CB1 receptors in the central nervous system. Outside of the central nervous system, THC binds with CB2 receptors. CBD is also thought to work closely with CB2 receptors, which are known to regulate the immune system. The human body does not have cannabinoid systems and receptors by accident.

These receptors were designed to work with natural cannabinoids that your body produces. There are actually two other types of endocannabinoid receptors, but scientists are still uncertain about what these receptors do.

Your cannabinoid system is responsible for processes involving learning, executive function, memory, emotions, sensory reception, motor function and decision making. Your cannabinoid receptors are located in the central nervous system and peripheral nerves. By making changes to the endocannabinoid system by taking CBD, you may be able to reduce your perceived pain and change any processes that are affected by the cannabinoid system.

The Benefits of CBD for Arthritis

Recent studies show that 42 percent of Baby Boomers already use CBD to help with their joint point. In animal research, CBD has been shown to have antioxidant, anti-inflammatory and pain-relieving properties. By taking CBD, you may be able to reduce the signs and symptoms of arthritis.

Pain Suppression

One of the major reasons why people use CBD for arthritis is to reduce pain. Recent studies show that 62.2 percent of marijuana users took marijuana for pain relief. Almost all seniors experience some kind of pain later in life, and CBD can help reduce this pain. Cannabis and CBD are especially useful for joint pain from conditions like arthritis.

Nerve Protectant

Interestingly, CBD can also protect your nerves. It helps to reduce joint neuropathy. This is one of the reasons why it is useful for conditions like arthritis, multiple sclerosis and cancer.

Joint Support

Another one of the ways CBD can help is by supporting the joints. Taking CBD can reduce the inflammation around your joints. Reduced inflammation can also improve the symptoms of other diseases as well.

Insomnia Reduction

When you are in a lot of pain, it can feel impossible to sleep at night. In one study of Sativex and rheumatoid arthritis, many participants were able to sleep better when they used the drug. Cannabinoid products can help reduce physical discomfort and inflammation, which can naturally improve the quality of your sleep.

How Can You Use CBD?

You no longer have to roll a joint to use cannabis. Instead, there is a wide variety of different methods available for taking CBD. From edibles to topicals, you can choose the option that works best for you.

Until recently, the legality of CBD was in question. Some states legalized medical marijuana and recreational marijuana, but marijuana was still illegal on a federal level. Since CBD is made from the cannabis plant, this essentially meant that CBD was illegal.

More recently, the 2018 Farm Bill finally became law. This bill essentially legalized hemp under federal law with a few important caveats. While growers could produce hemp and CBD, they were not allowed to produce THC. Farmers can legally grow hemp, but the hemp is not allowed to have any THC in it. Is CBD Safe?

One of the biggest problems with CBD is knowing how much to take and which drugs to avoid. Because CBD has not gone through major clinical trials yet, there are still many unknowns about things like the dosage and other factors. If a medication is strong enough to cause a cure, it is safe to assume that it is also strong enough to cause side effects and drug interactions. Current research and anecdotal reports generally indicate very few side effects associated with CBD, but there are some potential risks to keep in mind.

Because of the potential side effects, it is important to talk to your doctor before taking CBD. This is especially important if you have other medical conditions or take any medications. CBD can change how prescription medications are processed in the liver. This means it can potentially cause drug interactions with medications like Zofran, Clozaril, Endometrin, Luminal, Valium, Prilosec, Motrin, Celebrex, Paxil and Allegra.

In general, most experts agree that CBD is safe to take. It carries very low risks. Currently, there has never been a reported case of a CBD overdose. CBD can potentially cause drowsiness for some users, so you should remember this if you plan on operating heavy machinery or driving. How Can You Use CBD for Arthritis?

When you first start using CBD, it is a good idea to start with a low dosage. By doing this, you can give your body time to adjust to the medication. If you do not see results, you can always increase your dose later on. Most people take CBD twice a day. In the beginning, people often start with a dose between 5 and 10 milligrams. If this does not alleviate your symptoms, you can gradually increase your dosage incrementally until you reach up to 100 milligrams a day. While scientists still do not know how all of the cannabinoids work, it seems like some cannabinoids work better when they are taken together. For example, taking THC and CBD at the same time may increase the effectiveness of your dose. With a full-spectrum oil or isolate, you can get a range of cannabinoids instead of just CBD.

For arthritis pain, some people start by just using the product at night so that they can sleep better. You can also start by using a topical product or vaping so that you get immediate effects. Then, you can use edibles. Candies and edible products take longer to take effect, but the effects last longer. Vaping the extract allows CBD to get into your bloodstream quickly, which is useful for acute pain relief.

If you use CBD orally, remember that your body may be unable to absorb the CBD for around an hour. Once the oral CBD is absorbed, it can last for a long time. If you have localized pain, you may want to use a topical remedy like a salve, lotion or balm instead. When you apply a CBD gel on the affected area, you can instantly get relief for acute pain, swelling and inflammation.

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The Ultimate Guide to CBD and Seniors With Arthritis - Cleveland Scene

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EU5 Rheumatologists Expect the Introduction of Janssen’s Tremfya in Psoriatic Arthritis to Blunt Anticipated Growth of Eli Lilly’s Taltz, Novartis’…

Tuesday, June 23rd, 2020

EXTON, Pa., June 23, 2020 /PRNewswire/ --Spherix recently published the inaugural report of the semiannual report series included in their RealTime Dynamix: Psoriatic Arthritis (EU)service, which captured the responses of 246 EU5 rheumatologists surveyed last month. The market intelligence firm has been closely tracking the US psoriatic arthritis (PsA) market on a quarterly basis since 2016 and has observed a relatively stagnant treatment landscape over the past few years. However, the possible introduction of Janssen's IL-23 inhibitor, Tremfya, to both the EU and US PsA markets before the year is over will carry with it the debut of a novel class to the indication, likely causing a stir in rheumatologists' treatment algorithm.

According to the new Spherix report, TNF inhibitor use for the treatment of PsA across the EU5 remains widespread, accounting for two-thirds of all biologic/small molecule-treated patients. For adalimumab, etanercept and infliximab, use is relatively split between biosimilars and the branded reference agent (AbbVie's Humira, Amgen's Enbrel, and Janssen's Remicade, respectively), though use of Enbrel has been most eroded by generic competition.

When looking at use of alternate mechanism of action (AMOA) agents, Novartis' Cosentyx is the most penetrated brand across the EU5, showcasing the highest user base and self-reported brand share among all AMOA agents, followed by Janssen's Stelara. Eli Lilly's second-in-class IL-17 inhibitor, Taltz, has yet to reach the same heights as Cosentyx, and EU5 rheumatologists most often cite their level of experience as the key differentiator between the two agents. This, coupled with the fact that only one-quarter of respondents believe the two IL-17 inhibitors to be completely interchangeable, suggests that Taltz has ample room to grow (given more experience with the brand).

In fact, when assessing rheumatologists' six-month projected biologic/small molecule brand share in PsA, Taltz and Pfizer's Xeljanz are poised for the greatest growth. While Xeljanz is currently even-keeled with Taltz, Lilly's agent is expected to outgrow Pfizer's in the coming months, with anticipated share of Taltz expected to nearly double.

Despite the advantage of oral administration and a unique MOA in the EU PsA market, Xeljanz is struggling to surpass rheumatologists' expectations, and the majority of use is seen in second or later lines of therapy. Just shy of two years post EMA approval, respondents report long-term safety concerns as the most common primary barrier to use for the JAK inhibitor.

Interestingly, Spherix data included in a complementary service reveals EU5 rheumatologists' noticeable preference for Lilly's Olumiant over Xeljanz for the treatment of rheumatoid arthritis, and respondents perceive Olumiant's JAK 1/2 pathway to be the safest option regarding cardiovascular side effects. This is likely a contributing factor in addition to a longer tenure and multiple EMA-approved dosing options in RA to the slower anticipated uptake of Xeljanz in the EU5 PsA market, as prescribers may see the TNF or IL-17 inhibitors as more viable options concerning both safety and efficacy.

Nonetheless, Tremfya (guselkumab), which is in Phase 3 clinical trials for treatment in PsA, is currently under EMA review for EU approval. The introduction of the IL-23 inhibitor will be the first of its class and is expected to throw a curve in rheumatologists' current trajectories. Surveyed rheumatologists also provided six-month projected use patterns considering the commercialization of Tremfya in PsA, and respondents estimate the new entrant will capture a sizeable portion of the market.

As a result, in a post-Tremfya world, EU5 rheumatologists predict continued erosion of the TNF inhibitors and a significant reduction in the projected growth for Taltz and Xeljanz. Cosentyx share is also slated to decrease while Stelara and BMS' Orencia remain relatively stable. One-quarter of surveyed respondents consider Tremfya to be an advance over other treatments, and the majority cite "efficacy in skin/use in psoriasis" as the greatest advantage of the IL-23 class. On the other hand, perceived efficacy of the IL-23 inhibitors could also contribute to lackluster penetration of the class, as overall efficacy was also the number one disadvantage reported by rheumatologists, likely referring to unknown performance in joints for the treatment of PsA.

That is where other late-stage pipeline assets come in and set the stage for an even more dynamic future treatment landscape. Earlier this month, AbbVie announced the EMA regulatory application submission for their JAK inhibitor, Rinvoq (upadacitinib), for the treatment of PsA. While the JAK will likely come second to the Tremfya launch and will not bring with it the introduction of a novel class, early uptake and encouraging efficacy perceptions of Rinvoq for the treatment RA will likely translate to greater use in PsA (granted looming safety concerns surrounding the class do not prevail).

About RealTime DynamixRealTime Dynamix: Psoriatic Arthritis (EU)is an independent service providing strategic guidance through rapid and comprehensive semiannual reports, which include market trending, launch tracking, and a fresh infusion of unique content with each wave.

About Spherix Global InsightsSpherix Global Insights is a hyper-focused market intelligence firm that leverages our own independent data and expertise to provide strategic guidance, so biopharma stakeholders make decisions with confidence. We specialize in select immunology, nephrology, and neurology markets.

All company, brand or product names in this document are trademarks of their respective holders.

For more information contact:Kristen Henn, Business Development ManagerEmail:info@spherixglobalinsights.comwww.spherixglobalinsights.com

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SOURCE Spherix Global Insights

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EU5 Rheumatologists Expect the Introduction of Janssen's Tremfya in Psoriatic Arthritis to Blunt Anticipated Growth of Eli Lilly's Taltz, Novartis'...

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Rheumatoid Arthritis Diagnosis Tests Market Types, Trends, Size, Share, Industry Insights, Trends and Forecast upto 2025 – Cole of Duty

Tuesday, June 23rd, 2020

The latest report pertaining to Rheumatoid Arthritis Diagnosis Tests Market provides a detailed analysis regarding market size, revenue estimations and growth rate of the industry. In addition, the report illustrates the major obstacles and newest growth strategies adopted by leading manufacturers who are a part of the competitive landscape of this market.

Rheumatoid arthritis is a long-term, progressive and disabling autoimmune disease (as in this condition a persons immune system mistakes the bodys healthy tissues for foreign invaders). It is also a systemic disease, which means it affects the whole body. It causes inflammation, swelling, and pain in and around the joints and other body organs.

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It most commonly affects the hands and feet first, but it can occur in any joint. Its major symptoms includes; pain, swelling, and stiffness in more than one joint, symmetrical joint involvement, joint deformity, unsteadiness when walking, a general feeling of being unwell, fever, loss of function and mobility, weight loss, weakness and others. There are several different types of rheumatoid arthritis, some of them are seropositive RA, seronegative RA and JIA (juvenile idiopathic arthritis). It affects adults of any age, although most people are diagnosed between the ages of 40 and 60 and it is two to three times more common among women than men. A diagnosis of rheumatoid arthritis is based on the patients symptoms, a physical examination and the results of x-rays, scans and blood tests.

Global rheumatoid arthritis diagnosis tests market report is segmented on the basis of type, end-user and region & country level. Based upon type, global rheumatoid arthritis diagnosis tests market is classified into serology tests and monitoring rheumatoid arthritis treatment efficiency tests. The serology tests segment is further categorized into erythrocyte sedimentation rate, anti-cyclic citrullinated peptide, rheumatoid factor, antinuclear antibody, uric acid and others. The monitoring rheumatoid arthritis treatment efficiency tests segment is further categorized into muscle enzyme tests, salicylate level count and creatinine test. Based upon end-user, global rheumatoid arthritis diagnosis tests market is divided into hospitals, diagnostics laboratories and ambulatory surgical centers.

The regions covered in this Rheumatoid Arthritis Diagnosis Tests Market report are North America, Europe, Asia-Pacific and Rest of the World. On the basis of country level, the market of rheumatoid arthritis diagnosis tests is sub divided into U.S., Mexico, Canada, U.K., France, Germany, Italy, China, Japan, India, South East Asia, Middle East Asia (UAE, Saudi Arabia, Egypt) GCC, Africa, etc.

Key Players

Some major key players for Global Rheumatoid Arthritis Diagnosis Tests Market are Antibodies Inc., Euro Diagnostica AB, Qiagen NV, Siemens Healthcare GmbH, Bio Rad Laboratories Inc., Genway Biotech, Inc., Abbott Diagnostics, Beckman Coulter, Inc., F. Hoffmann-La Roche Ltd., Thermo Fisher Scientific Inc. and others.

Increasing Aging Population Coupled with the Increasing Prevalence of Rheumatoid Arthritis is Expected to Drive the Market Growth.

The major factor driving the growth of global rheumatoid arthritis diagnosis tests market is increasing aging population coupled with the increasing prevalence of rheumatoid arthritis globally. For example; As per National Center for Biotechnology Information, U.S.; The number of people with rheumatoid arthritis is projected to increase from 422,309 in 2015 to 579,915 in 2030. Health care costs for rheumatoid arthritis were estimated to be over $550 million in 2015, including $273 million spent on biologic disease-modifying antirheumatic drugs. Health care costs for rheumatoid arthritis are projected to rise to over $755 million by the year 2030.

In addition, increasing cases of obesity and growing cigarette smoking population are also anticipated to drive the growth of global rheumatoid arthritis diagnosis tests market. As Cigarette smoking significantly increases the risk of developing rheumatoid arthritis and obese people significantly have greater chance of developing rheumatoid arthritis than the healthy weight person. For example; the model created by Dr. Finkelstein and his colleagues at Duke and the Centers for Disease Control and Prevention estimated that the U.S. obesity rate will be at 42% by 2030. Furthermore, increasing awareness about the rheumatoid arthritis diagnosis tests and improving healthcare infrastructure are also supplementing the growth of the market. However, higher costs of these RA diagnostic test kits may hamper the market growth.

North America is Expected to Dominate the Global Rheumatoid Arthritis Diagnosis Tests Market

The global rheumatoid arthritis diagnosis tests market is segmented into North America, Europe, Asia-Pacific Latin America and Middle East & Africa. North America is expected to dominate the global rheumatoid arthritis diagnosis tests market within the forecast period attributed to the highly developed healthcare infrastructure and increased awareness in this region. Europe is projected to capture the significant share of global rheumatoid arthritis diagnosis tests market owing to the increasing obese population in this region. For example; The percentage of obese people in the countries of the European Union continues to increase every year. The dynamics of obesity growth in Europe is greater for men than for women (3.09% per year vs. 1.92% per year). With the growth rate remaining at the estimated level, in 2030 there will probably be more obese men (38.1%) than women (32.7%) in Poland, and in Europe likewise 36.6% and 32.0%, respectively. Asia Pacific is anticipated to witness a lucrative growth in global rheumatoid arthritis diagnosis tests market owing to the increasing research and development for new and more effective treatments and increasing cases of autoimmune diseases in this region.

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Rheumatoid Arthritis Diagnosis Tests Market Types, Trends, Size, Share, Industry Insights, Trends and Forecast upto 2025 - Cole of Duty

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Age at Arthroplasty, Disease Duration Increased With Time in Patients With Juvenile Idiopathic Arthritis – Rheumatology Advisor

Tuesday, June 23rd, 2020

Significant increases were observed over time in age at arthroplasty and disease duration before the first arthroplasty in patients with juvenile idiopathic arthritis (JIA), according to study results published in Arthritis Care & Research. Researchers noted that JIA category, calendar year of arthroplasty, and the presence of complications were significantly associated with implant survival.

Investigators conducted a retrospective cohort study of patients with JIA who underwent total joint replacement surgery at a hospital in Milan, Italy between January 1992 and June 2019. Demographic and clinical data were extracted from patients medical records. Patients were followed up from their arthroplasty for implant survival, complications, and/or revision surgeries. The primary aim of the study was to describe trends in arthroplasty. Implant survival was calculated using the Kaplan-Meier method; predictors of survival were identified using Cox regression models.

Between 1992 and 2019, a total of 198 arthroplasties were observed in 85 patients (65% women). Median age at first prosthesis was 22.7 years and median disease duration before the first implant was 17.4 years. The most represented JIA categories were polyarticular and systemic JIA. No significant differences in age at arthroplasty, disease duration before surgery, number of implants, and rate of complications were observed between JIA categories. The most frequently replaced joint was the hip, followed by the knee and ankle.

Compared with patients who underwent surgery before 2000, patients treated after 2010 were significantly older (mean ages, 21.93 vs 27.81 years, respectively). Similarly, mean disease duration before arthroplasty increased from 16.98 to 22.93 years. Rates of implant survival at 5, 10, and 15 years ranged from 84% to 89%, with 52% of implants lasting for 20 years. Compared with patients with polyarticular JIA, those with systemic JIA had lower survival rates at 10, 15, and 20 years (P <.001). According to multivariate analysis, the year of surgery was significantly associated with implant survival (hazard ratio [HR], 1.0004; 95% CI, 1.0002-1.0006; P <.001). The absence of complications predicted greater survival (HR, 3.69; 95% CI, 1.82-7.48; P <.001).

Between 1992 and 2019, significant upward trends were observed in age at arthroplasty and disease duration before arthroplasty in a cohort of patients with JIA. Procedure year, complications, and JIA subtype were each significantly associated with implant survival.

As study limitations, investigators noted the lack of data on implant functionality and health-related quality of life, as implant survival alone may have be an insufficient measure of arthroplasty experience. The upward trend in age at arthroplasty could have reflected the increased efficacy of other medical treatments, such as disease-modifying antirheumatic drugs.

The progressive improvement of medical treatment will lower the need for total joint replacement. Future researches should assess functional outcome and survival of implants in relation to medical therapy and different surgical approaches, the investigators wrote.

Reference

Marino A, Pontikaki I, Truzzi M, et al. Early joint replacement in juvenile idiopathic arthritis (JIA): trend over time and factors influencing implant survival [published online May 31, 2020]. Arthritis Care Res (Hoboken). doi:10.1002/acr.24337

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Age at Arthroplasty, Disease Duration Increased With Time in Patients With Juvenile Idiopathic Arthritis - Rheumatology Advisor

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What Is the Main Cause of Rheumatoid Arthritis? 4 Stages – MedicineNet

Saturday, June 20th, 2020

What is rheumatoid arthritis?

Rheumatoid arthritis is a chronic inflammatory disease characterized by pain and inflammation in joints, typically of the hands and feet. It is an autoimmune disease in which the immune system of the body attacks its own healthy cells, resulting in inflammation of the membrane lining the joints (synovial membrane) and damage to joint tissue.

Rheumatoid arthritis also affects other organs such as the skin, heart, lungs, and eyes. The annual incidence of rheumatoid arthritis is approximately three cases per 10,000 people worldwide.

What is the main cause of rheumatoid arthritis?

The exact cause of rheumatoid arthritis is unknown. However, some of the contributing factors to rheumatoid arthritis are:

What are the symptoms and signs of rheumatoid arthritis?

While rheumatoid arthritis is a chronic disease, there are times when symptoms worsen (flares) and times when the patient recuperates from the symptoms (remission). Some of the most common signs and symptoms of rheumatoid arthritis observed are:

What are the four stages of rheumatoid arthritis?

The American College of Rheumatology classifies rheumatoid arthritis into four stages, based on the disease progression and radiologic findings:

Based on the function of the patient, rheumatoid arthritis can be classified as:

How can be rheumatoid arthritis diagnosed?

Rheumatoid arthritis can be diagnosed based on its clinical presentation in the joints as well as using the following blood tests:

Radiographic findings are used by the doctor to assess the arthritis progression. The physician may suggest a magnetic resonance imaging (MRI) or joint aspiration for further evaluation.

What is the treatment for rheumatoid arthritis?

The goals of the treatment of rheumatoid arthritis include:

The treatment approach involves treating the disease with medication, education, and lifestyle modifications.

Drugs used to treat rheumatoid arthritis are:

Surgical treatment can be required for severe joint damage.

What are the complications of rheumatoid arthritis?

Rheumatoid arthritis can lead to the following complications:

Rheumatoid arthritis is not curable but with appropriate treatment, the disease can be controlled. Treatments are most effective when initiated early in the disease.

Medically Reviewed on 6/19/2020

References

https://emedicine.medscape.com/article/331715-overview

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What Is the Main Cause of Rheumatoid Arthritis? 4 Stages - MedicineNet

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