StemCell Therapy

Oregon State University research has provided the first complete, cellular-level look at whats going on in joints afflicted by osteoarthritis, a debilitating and costly condition that affects nearly one-quarter of adults in the United States.

The study, published in Nature Biomedical Engineering, opens the door to better understanding how interventions such as diet, drugs and exercise affect a joints cells, which is important because cells do the work of developing, maintaining and repairing tissue.

Research by the OSU College of Engineerings Brian Bay and scientists from the Royal Veterinary College in London and University College London developed a sophisticated scanning technique to view the loaded joints of arthritic and healthy mice loaded means under strain, such as an ankle, knee or elbow would be while running, walking, throwing, etc.

Imaging techniques for quantifying changes in arthritic joints have been constrained by a number of factors, said Bay, associate professor of mechanical engineering. Restrictions on sample size and the length of scanning time are two of them, and the level of radiation used in some of the techniques ultimately damages or destroys the samples being scanned. Nanoscale resolution of intact, loaded joints had been considered unattainable.

Bay and a collaboration that also included scientists from 3Dmagination Ltd (UK), Edinburgh Napier University, the University of Manchester, the Research Complex at Harwell and the Diamond Light Source developed a way to conduct nanoscale imaging of complete bones and whole joints under precisely controlled loads.

To do that, they had to enhance resolution without compromising the field of view; reduce total radiation exposure to preserve tissue mechanics; and prevent movement during scanning.

With low-dose pink-beam synchrotron X-ray tomography, and mechanical loading with nanometric precision, we could simultaneously measure the structural organization and functional response of the tissues, Bay said. That means we can look at joints from the tissue layers down to the cellular level, with a large field of view and high resolution, without having to cut out samples.

Two features of the study make it particularly helpful in advancing the study of osteoarthritis, he said.

Using intact bones and joints means all of the functional aspects of the complex tissue layering are preserved, Bay said. And the small size of the mouse bones leads to imaging that is on the scale of the cells that develop, maintain and repair the tissues.

Osteoarthritis, the degeneration of joints, affects more than 50 million American adults, according to the Centers for Disease Control and Prevention. Women are affected at nearly a 25 percent rate, while 18 percent of men suffer from osteoarthritis.

As baby boomers continue to swell the ranks of the U.S. senior population, the prevalence of arthritis will likely increase in the coming decades, according to the CDC.

The CDC forecasts that by 2040 there will be 78 million arthritis patients, more than one-quarter of the projected total adult population; two-thirds of those with arthritis are expected to be women. Also by 2040, more than 34 million adults in the U.S. will have activity limitations due to arthritis.

Osteoarthritis will affect most of us during our lifetimes, many to the point where a knee joint or hip joint requires replacement with a costly and difficult surgery after enduring years of disability and pain, Bay said. Damage to the cartilage surfaces is associated with failure of the joint, but that damage only becomes obvious very late in the disease process, and cartilage is just the outermost layer in a complex assembly of tissues that lie deep below the surface.

Those deep tissue layers are where early changes occur as osteoarthritis develops, he said, but their basic biomechanical function and the significance of the changes are not well understood.

That has greatly hampered knowing the basic disease process and the evaluation of potential therapies to interrupt the long, uncomfortable path to joint replacement, Bay said.

Bay first demonstrated the tissue strain measurement technique 20 years ago, and it is growing in prominence as imaging has improved. Related work is being conducted for intervertebral discs and other tissues with high rates of degeneration.

This study for the first time connects measures of tissue mechanics and the arrangement of the tissues themselves at the cellular level, Bay said. This is a significant advance as methods for interrupting the osteoarthritis process will likely involve controlling cellular activity. Its a breakthrough in linking the clinical problem of joint failure with the most basic biological mechanisms involved in maintaining joint health."

The Engineering and Physical Sciences Research Council, Arthritis Research UK, the Medical Research Council, and the Diamond-Manchester Branchline at Diamond Light Source supported this research.

Continued here:
To Your Health: Study paves way to better understanding, treatment of arthritis - The Chief News

KEY POINTS

Arthritis is a catch-all term for a series of painful conditions that cause tenderness and swelling of one or more joints.Rheumatoid arthritis and osteoarthritis are two of the most common types of arthritis.

The Joints Affected

Osteoarthritis usually affects the knees, spine, hips, and hands. Rheumatoid arthritis, on the other hand, oftentimes affects the wrists, hands, and feet.

While there is no cure for this painful condition, there are some lifestyle interventions that have been proven to alleviate the symptoms. Among these is consuming a well-known Christmas treat. gingerbread treatment for arthritis Photo: NickyPe - Pixabay

A Delicious Treatment

A key ingredient of the gingerbread man can help alleviate arthritis symptoms. Several studies have shown ginger extract helps a lot in alleviating joint pains caused by arthritis.

One prominent research revealed that ginger extract has the same efficacy as ibuprofen in the first treatment period. Another study also found that Echinacea and ginger supplements can reduce pain and inflammation after knee surgery. Echinacea is a well-known herb that is often taken to treat colds and flu.Researchers also discovered that highly concentrated doses of ginger extracts are very effective for the treatment of osteoarthritis of the knee.

The Study

The research involved volunteers who are experiencing moderate-to-severe knee pain. After taking ginger extracts, the volunteers said they felt lesser pain in their knees upon standing and after walking.

An animal study also revealed ginger could help relieve joint pains caused by rheumatoid arthritis. The findings of the researchers were further strengthened by another research which found ginger to be very effective in relieving human muscle pain due to an exercise-induced injury.

Volunteers who ingested at least two grams of raw or heated ginger reported the pain they felt somewhat lessened. The inflammation was also reduced. The volunteers applied ginger extract three times a day for twelve weeks, and during this time, they report having reduced levels of pain.

Researchers say that, while raw and heated gingers are equally helpful in alleviating joint pains, heat-treated ginger is believed to have a stronger effect. The studys findings also suggest applying a ginger-laced gel or cream directly to the affected area can also alleviate the painful symptoms.In many studies, researchers say ginger extracts can greatly improve osteoarthritis in the knees when it is applied topically.

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Relieve Joint Pains Caused By Arthritis This Christmas By Having This Treat - International Business Times

U.S. Rep. Debbie Dingell (D-12th District) voted in favor of H.R. 3, the Elijah E. Cummings Lower Drugs Costs Now Act. This landmark legislation will give Medicare the power to negotiate directly with the drug companies to lower the cost of prescription drugs for Medicare beneficiaries and Michiganders with private insurance.

Too many hardworking men and women face the terrifying high costs for prescription drugs and seniors dont have coverage for dental, vision, or hearing services, said Dingell. The House is delivering on the first step to lower prescription drug prices for the people. Since coming to Congress, I have led the fight to get Medicare to cover hearing aids and service. The eyes, ears, and teeth are just as much a part of healthcare. This bill invests savings from prescription drugs right back into expanding Medicare benefits to include dental, vision, and hearing.

Making hearing aids more affordable has been a priority for Dingell since coming to Congress. The first bill she ever introduced was the Medicare Hearing Aid Coverage Act to cover hearing aids for beneficiaries. Similar legislation passed the Energy and Commerce Committee this fall.

Right now, drug prices in the US are nearly four times higher than the combined average of 11 other similar countries, and Americans pay as much as 67 times more than consumers in other nations for prescription drugs.

Through allowing Medicare to directly negotiate the cost of prescription drugs, H.R. 3 will save patients and seniors $120 billion, and reinvest have a trillion dollars in expanding Medicare benefits to cover dental, vision, and hearing services, programs to address the opioid crisis, and research for new cures and treatments.

Diabetes About 9.8 percent of Michigan 864,882 people - are living with diabetes. For the most commonly used insulin medications, Michigan residents spend anywhere from $1,200 to $20,000 annually.

Under H.R. 3, Michigan residents could spend 3.5 times less on insulin. H.R. 3 can lower the average total cost of the insulin NovoLOG Flexpen by 76% from about $19,800 to $4,800 per year. Under H.R. 3, some commonly used insulins can cost as little as $400 per year.

Arthritis - 27 percent of Michigan residents have arthritis, 30.5% of whom experience severe joint pain because of it. H.R. 3 can lower their total costs on most arthritis drugs from about $40,000 to $10,000 per year.

Asthma About 10.8 percent or 310,955 Michigan residents live with asthma. H.R. 3 can lower their total costs on most asthma drugs from about $1,400 to $270 per year.

HIV/AIDS In 2015, 777 Michigan residents were diagnosed with HIV. H.R. 3 can lower their total costs on most HIV drugs from about $15,000 to $6,000 per year.

Give Medicare the power to negotiate directly with the drug companies to bring down prices and create powerful new tools to force drug companies to the table to agree to real price reductions.

Make the lower drug prices negotiated by Medicare available to Americans with private insurance too, not just those on Medicare.

Stop drug companies ripping off Americans while charging other countries less for the same drugs by limiting the maximum price for any negotiated drug.

Create a new $2,000 out-of-pocket limit on prescription drug costs for people on Medicare.

Save taxpayers approximately $500 billion over the next ten years and reinvest that savings

Save American households $120 billion.

Save private businesses more than $40 billion.

Save taxpayers approximately $500 billion and reinvests that savings to expand benefits.

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Dingell votes in favor of legislation to drastically lower the cost of prescription drugs - Dearborn Press and Guide

DEAR DR. ROACH: Are you aware of the possibility of pancreatitis resulting from long-term vitamin D2 supplementation? I was diagnosed with IPMN with chronic pancreatitis after being on 50,000 IU of vitamin D2 once a week for nine months. I had mild upper left quadrant pain, which I am told is quite unusual for pancreatic cysts. After doing some research, I decided to decrease and then stop the D2. As I did, cyst sizes and tumor markers both decreased. In addition, the pain resolved. I was fortunate enough to detect the connection, but have not had any interest from medical practitioners about looking into the possible link here. J.D.

ANSWER: This is a complex issue, and it starts with your IPMN, which stands for intraductal papillary mucinous neoplasms of the pancreas. These are tumors of the pancreas that are at risk for becoming cancerous.

The size is the biggest predictor of malignancy, so your doctors are likely monitoring the size of your tumors. Those less than 2 cm in size are at low risk for malignancy. Malignant and cancerous are synonymous terms, but the boundary between benign tumors and malignant ones is not as sharp a line as we used to think.

These cystic tumors are filled with mucin and can block the main pancreatic duct or a side pancreatic duct, through which the pancreatic enzymes that help to digest food flow into the small intestine. Insulin is also produced by the pancreas, but it is transported to the body through the splenic vein into the liver rather than the ducts into the intestine. Blockage of the ducts causes ductal dilation behind the obstruction. For the subset in whom the pancreatic ducts get blocked, IPMN can also cause inflammation of the pancreas, called pancreatitis.

Scientists observed that vitamin D levels D2 and D3, the usual kind we supplement are low in people with any kind of pancreatitis, but vitamin D treatment often made the pancreatitis worse. This seeming paradox was resolved when it was further found that the inflammatory cells in the inflamed pancreas were making the active form of vitamin D (1,25-dihydroxy vitamin D), and high levels of this active D vitamin were increasing calcium levels. The increase made pancreatitis worse. The low levels of circulating vitamin D2 and D3 are part of the bodys response to the elevated 1,25-dihydroxy vitamin D. Vitamin D supplementation is thus not usually done in pancreatitis since it can make it worse.

With the lessening of inflammation because you stopped the D2, its possible the cysts decreased in size and the ducts were able to go back toward normal, relieving inflammation in your case of IPMN.

DEAR DR. ROACH: I have just been diagnosed with a Bakers cyst behind my knee but received little information about it. Can you please tell me causes and cures? D.O.

ANSWER: A Bakers cyst is a common problem. It is a fluid collection behind the knee. In adults, these are usually due to increased joint fluid (from arthritis, a meniscal tear or trauma) communicating with the back of the knee through a one-way valve.

They are treated by addressing the underlying problem; for instance, anti-inflammatories and moderate exercise for arthritis. In addition, an injection of an anti-inflammatory into the joint space is usually successful in relieving symptoms. If a person is resistant to these treatments, an orthopedic surgeon has particular expertise in managing these.

Dr. Roach regrets that he is unable to answer individual letters, but will incorporate them in the column whenever possible. Readers may email questions to ToYourGoodHealth@med.cornell.edu or send mail to 628 Virginia Dr., Orlando, FL 32803.

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Vitamin D's odd connection with pancreas inflammation - Marshall News Messenger

Lifestyle Desk, , Updated Mon, 30 Dec 2019 09:27 AM IST

Uric acid is an rising drawback over time. Due to extend of this acid within the physique, an individual will get arthritis drawback. Arthritis causes swelling within the joints, inflicting insufferable ache. The impact of this ache begins displaying slowly on well being as nicely. Explain that the formation of uric acid within the physique is because of weak metabolism. Uric acid works by damaging blood cells. But yoga is one means which may eliminate this drawback. Today were telling you Three such yogasanas with the assistance of which youll management uric acid.

Abigale is a Masters in Business Administration by education. After completing her post-graduation, Abigale jumped the journalism bandwagon as a freelance journalist. Soon after that she landed a job of reporter and has been climbing the news industry ladder ever since to reach the post of editor at Our Bitcoin News.

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High Uric Acid Causes Arthritis And Joint Pain Yoga For Control - By controlling uric acid, these 3 Yogasanas will relieve joint ache, common follow -...

Tripterygium wilfordii, popularly known as thunder god vine root is primarily used for the treatment of rheumatoid arthritis in traditional Chinese medicine. The side effects of Trpterygium wilfordi are relatively low and hence it makes an attractive option for arthritis patients to improve their quality of life. Apart from an herbal approach in arthritis the Tripterygium wilfordii root is claimed to have antifertility, antiviral, and antitumor activities although not enough clinical evidence is available to support the claims.

This root extract is gaining significant acceptance among the arthritis patients due to its herbal nature and increasing consumers trust on herbal medicines. The regulatory aspects of herbal medicines favor the growth of herbal products market in USA, India, China and many European countries. This is expected to fuel the market growth of herbal products including Tripterygium wilfordii in the forecast period.

Tripterygium wilfordii Extract MarketSegmentation

The Tripterygium wilfordii root extract is segmented on the basis of dosage form, distribution channel and region. Tripterygium wilfordii is segmented on the bases of dosage form as tablets, capsules and powder. Originally available in powder form only, the benefits of Tripterygium wilfordii has created a costumer side demand and hence formulations of different kind have been developed and the shift in consumer trust towards herbal medicines is expected to drive the Tripterygium wilfordii market during the forecast period.

On the basis of distribution channel the Tripterygium wilfordii root extract market is segmented as retail, online retail, herbal specialty store and supermarket. With the increasing internet penetration in developing countries, the online sales of herbal supplements has also gained momentum and is expected at grow at a significant rate.

On the basis of region the Tripterygium wilfordii extract can be segmented into the following key regions; Western Europe, North America, Asia Pacific, Middle East and Africa. The Western European region, with its high expenditure on herbal medicine research is expected to drive the Tripterygium wilfordii market. The North American region has registered an ever increasing demand and acceptance in herbal products which is expected to further grow, contributing to a major factor for growth in the region. The Asia pacific region being the origin in use of Tripterygium wilfordii is also expected to see a steady increase in the market growth due to the a large populations belief in traditional remedie

Tripterygium wilfordii Extract Global Market Trends and Market Drivers:

The trends in use of traditional or herbal medicines is different for different regions, for example manufacturers do not need to register their products with FDA in US or get an approval, these are sold as dietary supplements. For this reason a large number of herbal products are flooding the American market and gaining high acceptance among masses.

The increased focus in innovation in herbal products in Western Europe is generating supply side demand and countries like Germany and France are spending high amounts on research. This is expected to act as a driving tool for the growth of the herbal product market including Tripterygium wilfordii root extract.

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In Indian regulatory system the marketing and sales of herbal products are furthermore liberal, herbal products are established products being used from a long time hence there is no safety study required for established products. This is expected to catalyze the growth of Tripterygium wilfordii root extract market.

The Tripterygium wilfordii root market is of great potential due to the above limited regulations and the high amount of faith in people for the use of herbal products. The unavailability of herbal practitioners and high concentration of the practitioners in certain regions is expected to be a major restrain in Tripterygium wilfordii root market.

Tripterygium wilfordii Extract Market Key Players:

The Tripterygium wilfordii powder from Asia Pacific constitutes for a major market share and hence some of the key prayers are also concentrated in these areas. Some of the key global players include; Shaanxi Jintai Biological Engineering Co., Ltd., Xian Hao-Xuan Bio-Tech Co., Ltd., Hunan Jin Kang Biotechnology Co., Ltd., Stanford Chemicals Co. Organic Herb Inc. among others.

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Tripterygium wilfordii Extract Market : Macroeconomic Factors to Create Positive Impact on the Industry Growth and its Potential - Market Research...

OBJECTIVES:

We aimed to assess the safety and efficacy of tocilizumab as monotherapy or in combination with methotrexate in a routine clinical practice setting in Tunisian patients with RA who did not respond to conventional treatment with disease-modifying anti-rheumatic drugs (DMARDs-IR).

A total of 51 DMARDs-IR adult patients with moderate to severe RA participated in a phase IIIb, open-label clinical trial. Patients received 8 mg/kg of tocilizumab every 4 weeks in combination with a DMARD or as monotherapy during 24 weeks. The study was extended to 24 other weeks for those who had at least a moderate response at the end of the initial phase. Safety and efficacy of tocilizumab were analysed.

Four patients discontinued treatment prematurely due to an adverse event. The most common AEs were hypercholesterolemia (18 cases), increased triglycerides (17 cases), increased transaminases (15 cases), rash (14 cases), neutropenia (7 cases), digestive disorders (3 cases) and respiratory disorders (3 cases). After 52 weeks, 90.5% of patients responded to treatment. At the end of the study, 61.9% of the patients had a mild RA and almost 50% of patients were in remission. Overall, 29.2, 6.3 and 4.3% of patients achieved ACR20, ACR50 and ACR70 responses, respectively. Additionally, the study showed a significant improvement in all individual parameters of ACR core data.

Treatment with tocilizumab was well tolerated and showed a fast and sustained efficacy in Tunisian patients with moderate to severe active RA who had an inadequate response to DMARDs.Key Points Up to 40% of RA patients remain inadequate responders to a prior csDMARD or a tumour necrosis factor inhibitor (TNFi) biological agent. A non-TNF biological agent like tocilizumab with or without methotrexate is recommended in those patients. In this study, tocilizumab treatment improved the number of responders, the number of patients in remission, and the evolution of disease activity. The meaningful clinical improvement seen denotes a rapid and sustained response to treatment. Tocilizumab presented a favourable safety profile with few withdrawals due to AEs, consistently with what was observed in other trials. This study provides new information about the safety and efficacy of tocilizumab in a patient population resembling that expected in clinical practice among the Tunisian population.

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Safety and Efficacy of Tocilizumab as Monotherapy or in Combination with Methotrexate in Tunisian Patients with Active Rheumatoid Arthritis and...

Paddy McGuinness, 46, revealed in an Instagram post last year that at the age of 44 hed been diagnosed with arthritis. Arthritis is a common condition that causes pain and inflammation in a joint.

Arthritis charity Arthritis Research UK said at the time: Were grateful to Paddy McGuinness for speaking out and showing other young people with arthritis that they are not alone.

People often think of arthritis as an older person's disease.

But Paddy is actually one of 11.8 million people under the age of 65 living with a musculoskeletal condition, including 2.7 million under 35 years old."

The two most common types of arthritis are osteoarthritis and rheumatoid arthritis.

DON'T MISS

The main symptoms of osteoarthritis are pain and stiffness in your joints, according to the NHS, which can make it difficult to move the affected joints and do certain activities.

It adds: The symptoms may come and go in episodes, which can be related to your activity levels and even the weather. In more severe cases, the symptoms can be continuous.

You should see your GP if you have persistent symptoms of osteoarthritis so they can confirm the diagnosis and prescribe any necessary treatment.

Other symptoms you or your doctor may notice include:

Osteoarthritis can affect any joint in the body, but the most commonly affected areas are the knees, hips and small joints in the hands.

In osteoarthritis, the protective cartilage on the end of bones breaks down.

The main symptoms of rheumatoid arthritis are joint pain, swelling and stiffness.

The NHS advises: It may also cause more general symptoms, and inflammation in other parts of the body.

The symptoms of rheumatoid arthritis often develop gradually over several weeks, but some cases can progress quickly over a number of days.

The symptoms vary from person to person. They may come and go, or change over time.

You may experience flares when your condition deteriorates and your symptoms become worse.

Rheumatoid arthritis is an autoimmune disease, which means the immune system attacks the cells that line joints by mistake.

If you think you have the symptoms of osteoarthritis or rheumatoid arthritis, see your GP.

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Paddy McGuinness health: Star diagnosed with debilitating condition - the symptoms - Express

According to a new market study, the Rheumatoid Arthritis Treatment Market is projected to reach a value of ~US$XX in 2019 and grow at a CAGR of ~XX% over the forecast period 2017-2027. The presented study ponders over the micro and macro-economic factors that are likely to influence the growth prospects of the Rheumatoid Arthritis Treatment Marketover the assessment period.

The market report throws light on the current trends, market drivers, growth opportunities, and restraints that are likely to influence the dynamics of the Rheumatoid Arthritis Treatment Market on a global scale. The Five Force and SWOT analysis included in the report provides a fair idea of how the different players in the Rheumatoid Arthritis Treatment Market are adapting to the evolving market landscape.

ThisPress Release will help you to understand the Volume, growth with Impacting Trends. Click HERE To get SAMPLE PDF (Including Full TOC, Table & Figures) at https://www.futuremarketinsights.co/reports/sample/REP-GB-3119

Analytical insights enclosed in the report:

The report splits the Rheumatoid Arthritis Treatment Marketinto different market segments including, region, end-use, and application.

The report provides an in-depth analysis of the current trends that are expected to impact the business strategies of key market players operating in the market. Further, the report offers valuable insights related to the promotional, marketing, pricing, and sales strategies of the established companies in the Rheumatoid Arthritis Treatment Market. The market share, growth prospects, and product portfolio of each market player are evaluated in the report along with relevant tables and figures.

The study aims to address the following doubts related to the Rheumatoid Arthritis Treatment Market:

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key players and products offered

Potential and niche segments, geographical regions exhibiting promising growth

A neutral perspective on market performance

Must-have information for market players to sustain and enhance their market footprint

NOTE All statements of fact, opinion, or analysis expressed in reports are those of the respective analysts. They do not necessarily reflect formal positions or views of Future Market Insights.

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Rheumatoid Arthritis Treatment Market To Witness A Considerable CAGR Growth Through The Forecast Period 2017-2027 - Info Street Wire

Systemic Idiopathic Juvenile Arthritis Treatment Market (2018) Report Provides an in-depth summary of Systemic Idiopathic Juvenile Arthritis Treatment Market Status as well as Product Specification, Technology Development, and Key Manufacturers. The Report Gives Detail Analysis on Market concern Like Systemic Idiopathic Juvenile Arthritis Treatment Market share, CAGR Status, Market demand and up to date Market Trends with key Market segments.

The latest report about the Systemic Idiopathic Juvenile Arthritis Treatment market provides a detailed evaluation of the business vertical in question, alongside a brief overview of the industry segments. An exceptionally workable estimation of the present industry scenario has been delivered in the study, and the Systemic Idiopathic Juvenile Arthritis Treatment market size with regards to the revenue and volume have also been mentioned. In general, the research report is a compilation of key data with regards to the competitive landscape of this vertical and the multiple regions where the business has successfully established its position.

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Leading manufacturers of Systemic Idiopathic Juvenile Arthritis Treatment Market:

Alteogen Inc.Bristol-Myers Squibb CompanyEpirus Biopharmaceuticals, Inc.Johnson & JohnsonMomenta Pharmaceuticals, Inc.Mycenax Biotech Inc.Novartis AGOncobiologics, Inc.

Segment by RegionsNorth AmericaEuropeChinaJapanSoutheast AsiaIndia

Segment by TypeAdalimumab BiosimilarCanakinumabGolimumabTocilizumab BiosimilarOthers

Segment by ApplicationClinicHospitalOthers

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Scope of The Systemic Idiopathic Juvenile Arthritis Treatment Market Report:

This research report for Systemic Idiopathic Juvenile Arthritis Treatment Market explores different topics such as product scope, product market by end users or application, product market by region, the market size for the specific product Type, sales and revenue by region forecast the Market size for various segments. The Report provides detailed information regarding the Major factors (drivers, restraints, opportunities, and challenges) influencing the growth of the Systemic Idiopathic Juvenile Arthritis Treatment market. The Systemic Idiopathic Juvenile Arthritis Treatment Market Report analyzes opportunities in the overall Systemic Idiopathic Juvenile Arthritis Treatment market for stakeholders by identifying the high-growth segments.

A detailed overview of the geographical and competitive sphere of the Systemic Idiopathic Juvenile Arthritis Treatment market:

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Table of Content of The Report

Chapter 1- Systemic Idiopathic Juvenile Arthritis Treatment Industry Overview:

1.1 Definition of Systemic Idiopathic Juvenile Arthritis Treatment

1.2 Brief Introduction of Major Classifications

1.3 Brief Introduction of Major Applications

1.4 Brief Introduction of Major Regions

Chapter 2- Production Market Analysis:

2.1 Global Production Market Analysis

2.1.1 Global Capacity, Production, Capacity Utilization Rate, Ex-Factory Price, Revenue, Cost, Gross and Gross Margin Analysis

2.1.2 Major Manufacturers Performance and Market Share

2.2 Regional Production Market Analysis

Chapter 3- Sales Market Analysis:

3.1 Global Sales Market Analysis

3.2 Regional Sales Market Analysis

Chapter 4- Consumption Market Analysis:

4.1 Global Consumption Market Analysis

4.2 Regional Consumption Market Analysis

Chapter 5- Production, Sales and Consumption Market Comparison Analysis

Chapter 6- Major Manufacturers Production and Sales Market Comparison Analysis

Chapter 7- Major Classification Analysis

Chapter 8- Major Application Analysis

Chapter 9- Industry Chain Analysis:

9.1 Up Stream Industries Analysis

9.2 Manufacturing Analysis

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Systemic Idiopathic Juvenile Arthritis Treatment Market By Production, Manufacturer, Revenue Analysis And Forecast To 2029 - Bulletin Line

.

My grand daughter is 6 years old and my goal is to be physically and mentally fit to enjoy her. Well after five years it was not going so well. I had a very serious sit down conversation with self last year around this time. No more minute resolutions. No more unmet goals. No more start and stop diets. I need help; this has been a 65 + year journey and things were not going as well as I had hoped. I downloaded a habit tracker and put short doable daily and weekly goals. For movement, I have the following daily goals:

I also have a weekly hot yoga class at 7 AM on Sunday mornings that I look forward to. The class is 90 minutes of stretching and meditating in the heat which is awesome for arthritis which is in various places in my body.

Over the year, I lost weight, my flexibility increased and my diet shifted as I no longer craved foods that were not good for me. Honestly, I did other things such as increase my prayers, meditation, breathing and affirmation practices. But the key was the physical movement it always accelerated all the other practices. While I did not always do every practice every day, the habit tracker helped me stay on target by starting my count over when I missed a practice.

This year both my mind and body are in a better place than last year. The goal for 2020 is to add real cardio and reap more relief for sleep and stress. I joined my local gym last month; my plan is to enroll in a few classes and add it to my habit tracker. Slow progress is still progress.

Weekly Prompt

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This time last year I laughed and cried with my body - Thrive Global

Helen Aristar-Dry likes to garden, but she doesnt want the aches and pains that could follow an enjoyable time spent out at her 1-acre property in Dripping Springs.

Ive always been interested in easier ways to garden, said Aristar-Dry, 73, who has had rheumatoid arthritis for about 50 years. For someone like herself, she said, Youre always looking for ways to lessen the strain on your joints.

Rheumatoid arthritis is an autoimmune and inflammatory disease that often affects hands, wrists, knees and ankles. Symptoms can include swelling, pain and stiffness in more than one joint, as well as fatigue and weakness.

Over the years having had several surgeries and used a wheelchair at times she has learned tactics to help her out. Sitting alongside her raised bed gardens used for growing Swiss chard and kale, along with other things she is glad she can still relish working with flowers, vegetables and dirt.

Its just really a good pastime, she said.

Aristar-Dry has a doctorate in linguistics, and after she retired in 2013, she had more time for a favorite hobby. She became a Hays County master gardener in 2015, and she has researched a variety of ways to make it easier for her in the garden.

Evaluating her resources and careful planning have helped, Aristar-Dry said. In addition to finding assistance for heavy jobs, she divides up large tasks into shorter chunks.

I rarely work more than 30 minutes at a time, she said. By then my hands will be hurting, so its time to quit.

If I overdo it, Im going to feel bad, she said. She also keeps a to-do list, so I can see whats a good job that fits the time I have. I dont do big projects.

In addition, she opts to use equipment that isnt weighty. I use a childrens rake with a long handle, because its much lighter, she said. Its less stress on the joints if you dont have to carry heavy stuff around. She uses a cart, rather than a wheelbarrow, to move large items such as bags of dirt.

She needs to be more vigilant about keeping her tools sharpened so they dont require as much strength to use, she said. Thats one I need to work on, but it makes a big difference.

Effective use of logistics has also aided her, and that can be as simple as storing her tools near the garden. Shes a big advocate of raised beds of all kinds where she can even sit down to work.

Theyre less demanding physically, she said. As well, she wishes she had more space between garden beds to allow more room for a bench or a cart to get through the path.

She carefully selects plants that are easier to care for, such as drought-tolerant natives, she said. As well, she likes to use plants that have been designated as Texas Superstars, which perform well under Texas tough growing conditions, according to texassuperstar.com.

Aristar-Dry prefers to use perennial plants rather than annuals, because with perennials, you put them in once and they come back, she said. Perennials are just much easier.

She keeps in mind some ergonomic principles, such as using her joints in a neutral position, which she described as about midpoint of their range, and other basics. In addition, she helps limit discomfort through the selection of ergonomically designed gardening tools. These tools help the user reduce stress and injuries from overuse of the body.

She has some long-handled tools that can help let her back remain straight. Some tools such as a waist-high weeder have an O-shaped handle that offers more grip surface, and its easy to use two hands with, she said.

Along with other selection criteria, she picks various tools that can let her keep her wrist straight, she said. (Often, she said, many tools require users to bend their wrists.)

Other implements can also help; she uses a special faucet turner to make it easier to turn on and off the water outside so she doesnt have to use as much strength. She uses a garden kneeler that can serve as a seat, she said. When I sit down and keep my back straight, I can work a whole lot longer.

Putting together information on the tactics she uses, as well as including more details about ergonomics and such, she has given a presentation on called Ergonomic Gardening: Gardening to Avoid Aches and Pains about a half-dozen times at the Hays County Master Gardeners Associations In the Garden series. Emphasizing that she doesnt have any medical training but that she has found these methods useful to her.

The talk is popular, said Phyllis Janowski, past president of the Hays County Master Gardeners Association.

People found it helpful to learn about some measures they could take, even for those who dont usually get aches and pains from gardening, she said.

Now that Aristar-Dry has found workarounds to help her, she still gets to take joy in the garden, she said. I think its really just rewarding to be out there with growing things.

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Find the right tools to garden with arthritis - austin360

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Arthritis is caused by inflammation of the joints. There are many foods and ingredients that can ease inflammation and may help relieve some of the joint pain associated with arthritis. Adding these foods to a healthy diet can help alleviate our arthritis symptoms. Lets have a look on list of food and ingredients that we can try using at our homes in order to get some relief from the arthritis-related pain.

Grains

While considering our options in the bread, cereal, and pasta, we should avoid refined grains. Not only are they highly processed grains but limited in nutrition, can lead to inflammation throughout the body. For Example, switching from refined flour to whole-wheat flour in our recipes can increase the intake of nutrients and potentially lower inflammation. Likewise, barley is filled with 6 grams of fiber per cup, a perfect addition to soups, stews and risotto dishes.

Nut and seeds

Nuts and seeds are a useful component in our diet. Most importantly it offers a variety of health benefits to people with arthritis. With their high ALA content, nuts like walnuts are omega-3-containing and researchers studying their effects have found that they lower C-reactive protein (CRP), an inflammation marker linked to an increased risk of cardiovascular disease and arthritis. Likewise, chia seeds are also an excellent source of anti-inflammatory ALA, but their greatest benefit is likely their high fiber content.

Fruit and vegetables

Fruits are naturally sweet and have a substantial amount of antioxidants, protein, vitamins, minerals, and other nutrients, just like red raspberries, tart cherries and strawberries are filled with antioxidants that help to get rid of radicals that encourage inflammation whereas Vegetables are rich in antioxidants and other nutrients that protect against cell damage and lower inflammation throughout the body, including in the joints. For example, fresh, leafy vegetables such as broccoli, spinach, brussels sprouts, kale, swiss chard, and bok choy are loaded with antioxidants such as vitamins A, C, and K which protect cells from free radical harm.

Spices

According to traditional Eastern medicine, ginger and turmeric are two spices that have anti-inflammatory properties. Along with its anti-inflammatory properties, some studies have shown ginger can also reduce osteoarthritis symptoms, if not in food one can also opt-in the form of a herbal supplement -like IMOVE containing popular, active and trusted pain management ingredients such as ginger and turmeric. It also includes Glucosamine & Chondroitin for joint repair and lubrication, thereby offering full joint treatment.

Fish

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are called marine fatty acids as they are derived from fish, adding omega-3 sources to our diets inflammation could be reduced. Fatty fish such as salmon, tuna, sardines, and mackerel are the best sources of marine omega-3s. Anti-inflammatory effects of omega-3s are helpful not only for the relief of arthritis but also for the prevention of other inflammatory diseases, such as heart disease. It is usually suggested to eat 3 to 6ounce serving of these fish two to four times a week to reduce inflammation and protect the heart Omega-3-rich fishes are also high in mercury, which causes brain and nervous system can harm if consumed in large quantities. Its important to choose smaller fish that have less mercury.

(Disclaimer: Writer is Sargam Dhawan, Director, Planet Herbs Lifesciences Pvt Ltd. Views expressed are a personal opinion.)

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Food and ingredients to cure arthritis! - Elets

Goldman Sachs is bullish on these health care stocks.

Last U.S. presidential election season, health care stocks didn't perform very well. Political headline risk related to drug pricing and "Medicare for All" could weigh on health care valuations again in 2020. Fortunately for investors, the Goldman Sachs analyst team says there are still plenty of opportunities for long-term investors to buy health care stocks heading into an election year. Goldman says valuations are reasonable, aggressive policy changes are unlikely, innovation and product development are booming and there is consolidation potential in the sector as well. Here are Goldman's eight high-conviction health care stock ideas for 2020.

Amgen (ticker: AMGN)

Amgen is a global biopharmaceutical company that markets drugs for oncology and inflammation. Analyst Terence Flynn says Amgen will likely outperform consensus revenue and earnings per share estimates in 2020 and 2021. After winning a patent battle against arthritis drug Enbrel in August and acquiring plaque psoriasis and psoriatic arthritis drug Otezla shortly thereafter, Flynn says Amgen is on track to grow revenue by between 4% and 8% annually over the next four years. Data on Tezepelumab and AMG 510 may also be near-term catalysts. Goldman has a "buy" rating and $279 price target for AMGN stock.

BioMarin Pharmaceutical (BMRN)

BioMarin is a biopharma company focused on the treatment of serious rare and ultra-rare diseases. Analyst Salveen Richter says BioMarin has a diversified portfolio of treatments that is positioned to deliver more than 20% revenue growth in 2020. Richter estimates BioMarin's seven core commercial products will generate a combined $1.7 billion in fiscal 2019 revenue and peak at more than $6 billion in combined revenue in 2030. Richter estimates peak sales for BioMarin's gene therapy treatment for hemophilia A at $1.3 billion. Goldman has a "buy" rating and $157 price target for BMRN stock.

Incyte Corp. (INCY)

Incyte is a biotech company focused on hematology, oncology and inflammation. Richter says Incyte's lead drug Jakafi is on track for $2.9 billion in peak 2028 sales. In addition, he says Incyte has a strong development pipeline of 21 drugs, with eight already in pivotal-stage clinical trials. Phase III Gravitas-301 data for itacitinib in steroid nave acute graft-versus-host disease should be a near-term catalyst. Richter is anticipating updates from the company's dermatology franchise in the first half of 2020. Goldman has a "buy" rating and $122 price target for INCY stock.

Iqvia Holdings (IQV)

Iqvia is a global advanced analytics, technology and life sciences research company. Analyst Robert Jones says Iqvia is a large-cap growth stock, and its research segment should be particularly strong in 2020. Jones says the market isn't fully appreciating Iqvia's technology segment, which is producing healthy organic revenue growth due to solid demand for real-world evidence. Jones says the election cycle could drive RWE demand in 2020, differentiating Iqvia from other health care stocks that have negative headline risk. Goldman has a "buy" rating and $191 price target for IQV stock.

UnitedHealth Group (UNH)

UnitedHealth is one of the largest global managed care organizations. Analyst Stephen Tanal says United's commercial, Medicare Advantage and Medicaid businesses are all attractive, and its Optum acquisition gives the company access to a unique collection of data and services. Goldman is projecting more than $19 billion in operating cash flow in 2020, with only about $2.3 billion needed for capital expenditures and share buybacks. Tanal says 2020 guidance is conservative, and UnitedHealth is well-positioned for at least 13% annual EPS growth. Goldman has a "buy" rating and $330 price target for UNH stock.

Vertex Pharmaceuticals (VRTX)

Vertex is a biopharma company focused on developing treatments for cystic fibrosis. Vertex is also developing a pipeline of therapies for pain, sickle cell disease, kidney disease and other conditions. Vertex shares gained 25% in the past three months, and Richter says Vertex is on track for impressive EPS growth in the coming years due to its multiple pipeline drivers. Goldman has a "buy" rating and $285 price target for VRTX stock.

Story continues

Dentsply Sirona (XRAY)

Dentsply Sirona is one of the largest manufacturers of dental office solutions, including consumables and high-end equipment. Analyst Nathan Rich says Dentsply Sirona's new Primescan intraoral scanner should benefit from long-term demand and be a major contributor to 2020 revenue growth. In the longer-term Primescan upgrade programs could drive additional revenue upside. In addition, new product launches and the company's One DS loyalty program could be bullish catalysts. Rich says the company's restructuring efforts appear to be ahead of schedule, suggesting potential margin growth opportunities ahead. Goldman has a "buy" rating and $66 price target for XRAY stock.

Zoetis (ZTS)

Zoetis is the global leader in animal health medicines and vaccines. Rich says Simparica Trio could be the world's first $1 billion animal health drug and has the potential to add as much as 30 percent to Zoetis EPS. Favorable pricing and product mix should contribute to cash flow growth and boost margins as well. Finally, Rich says the company's expansion to diagnostics and new pain drugs may be long-term growth opportunities as well. Pet care has also historically been relatively recession-proof, potentially limiting downside risk. Goldman has a "buy" rating and $148 price target for ZTS stock.

Goldman Sachs' top health care stocks for 2020:

-- Amgen (AMGN)

-- BioMarin Pharmaceutical (BMRN)

-- Incyte Corp. (INCY)

-- Iqvia Holdings (IQV)

-- UnitedHealth Group (UNH)

-- Vertex Pharmaceuticals (VRTX)

-- Dentsply Sirona (XRAY)

-- Zoetis (ZTS)

More From US News & World Report

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Goldman's 8 Highest-Conviction Health Care Stocks to Buy - Yahoo Finance

Study on the Rheumatoid Arthritis Treatment Market

The comprehensive report published by Future Market Insights (FMI) offers an in-depth intelligence related to the various factors that are likely to impact the demand, revenue generation, and sales of the Rheumatoid Arthritis Treatment Market. In addition, the report singles out the different parameters that are expected to influence the overall dynamics of the Rheumatoid Arthritis Treatment Market during the forecast period 2017-2027.

As per the findings of the presented study, the Rheumatoid Arthritis Treatment Market is poised to surpass the value of ~US$ XX by the end of 2029 growing at a CAGR of ~XX% over the assessment period 2017-2027. The report includes a thorough analysis of the upstream raw materials, supply-demand ratio of the Rheumatoid Arthritis Treatment in different regions, import-export trends and more to provide readers a fair understanding of the global market scenario.

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Rheumatoid Arthritis Treatment Market Industry Analysis, Trend and Growth, 2017-2027 - Info Street Wire

Global Drugs for Rheumatoid Arthritis Market research report gives a comprehensive outlook of the markets 2019-2025 and offers an in-depth summary of the current market status, historic, and expected way forward for the Drugs for Rheumatoid Arthritis Market. Additionally, to this, the report provides data on the restraints negatively impacting the markets growth. The report includes valuable information to assist new entrants, as well as established players, to understand the prevailing trends in the Market.

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Key Objectives of Drugs for Rheumatoid Arthritis Market Report: Study of the annual revenues and market developments of the major players that supply Drugs for Rheumatoid Arthritis Analysis of the demand for Drugs for Rheumatoid Arthritis by component Assessment of future trends and growth of architecture in the Drugs for Rheumatoid Arthritis Market Assessment of the Drugs for Rheumatoid Arthritis Market with respect to the type of application Study of the market trends in various regions and countries, by component, of the Drugs for Rheumatoid Arthritis Market Study of contracts and developments related to the Drugs for Rheumatoid Arthritis Market by key players across different regions Finalization of overall market sizes by triangulating the supply-side data, which includes product developments, supply chain, and annual revenues of companies supplying Drugs for Rheumatoid Arthritis across the globe

Major Players included in this report are as follows AbbVie IncHoffman-La Roche AGAmgen IncPfizer IncBristol-Myers Squibb CoJohnson & JohnsonUCB Biosciences IncMitsubishi Tanabe Pharma CorpBiogen IncMerck & CoMarket Segment by Product TypePharmaceuticalsBiopharmaceuticals

Drugs for Rheumatoid Arthritis Market can be segmented into Product Types as PrescriptionOTC

Drugs for Rheumatoid Arthritis Market can be segmented into Applications as HospitalClinicsOther

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Drugs for Rheumatoid Arthritis Market: Regional analysis includes:Asia-Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)Europe (Turkey, Germany, Russia UK, Italy, France, etc.)North America (United States, Mexico, and Canada.)South America (Brazil etc.)The Middle East and Africa (GCC Countries and Egypt.)

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Table of Contents1 Industry Overview of Drugs for Rheumatoid Arthritis2 Manufacturing Cost Structure Analysis3 Development and Manufacturing Plants Analysis of Drugs for Rheumatoid Arthritis4 Key Figures of Major Manufacturers5 Drugs for Rheumatoid Arthritis Regional Market Analysis6 Drugs for Rheumatoid Arthritis Segment Market Analysis (by Type)7 Drugs for Rheumatoid Arthritis Segment Market Analysis (by Application)8 Drugs for Rheumatoid Arthritis Major Manufacturers Analysis9 Development Trend of Analysis of Drugs for Rheumatoid Arthritis Market10 Marketing Channel11 Market Dynamics12 Conclusion13 Appendix

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Drugs for Rheumatoid Arthritis Market 2019 Global Share, Trend, Segmentation and Forecast to 2025 - Market Research Sheets

Global Septic Arthritis Treatment Market 2019 by Company, Regions, Type and Application, Forecast to 2024offers an orderly representation of the market that proposes a positive growth rate in the upcoming years. The report contains the combinations, methods, summarized study, and data gathered from various sources. The research experts have studied the historical data and provided an idea of the direction this market will take in the forthcoming years. The report involves key insights pertaining to industry deliverables, particularly market trends, market share, market competitors and recognized players, market size, current valuation, and revenue estimations for the forecast period from 2019 to 2024. The research study is reliable, wide-ranging, and the result of strong analytical research on theSeptic Arthritis Treatmentmarket.

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The report investigates evaluates theSeptic Arthritis Treatmentmarket on the basis of market segments and geographical areas and current market trends. Various factors such as development, rapidly increasing demand, economic stability are directly and indirectly fuelling growth in the market are also covered in the report. An assessment of the technical barriers, other issues, as well as market restraints is determined. Key market competitors who majorly hold the market shares in terms of demand, supply, and income through their products, services, and after deal processes are studied and their comprehensive abstract has been provided in the report.

The report encloses a precise evaluation of theSeptic Arthritis Treatmentmarket, including growth rate, current scenario, and volume inflation prospects, on the basis of Porters Five Forces analysis. It provides reliable and authentic projections regarding the market. The report has thoroughly studied the market report on the basis of R&D developments, distribution channels, industrial penetration, manufacturing processes, and revenue.

Lupin Pharmaceuticals (US), F. Hoffmann-La Roche Ltd (Swtizerland), AbbVie Inc (US), Amgen Inc (US), Bristol-Myers Squibb Company (US), Johnson & Johnson (US), Pfizer (US),

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Global Septic Arthritis Treatment Market Growth (Status and Outlook) 2019-2024 | Exclusive Report by Magnifier Research - Market Research Sheets

Auranofin is a gold-containing salt with chemical formula and name C20H34AuO9PS and Gold, 2,3,4,6 tetraacetate respectively. It is used for treatingarthritis and is classified as an antirheumatic agent by World Health Organization and is also called disease-modifying antirheumatic drug (DMARD). Antirheumatic drugs are the ones that are used in the treatment of rheumatism. Auranofin is known by different names in different countries. Auranofin improves arthritis symptoms like painful, tender and swollen joints and morning stiffness. Also, it is said to decrease the pain by reducing inflammation and it slows down or stops the immune system from attacking the joints and Auranofin acts by inhibiting DNA synthesis. Auranofin should be considered only when other non-steroidal anti-inflammatory drugs and appropriate steroids are ineffective in controlling the symptoms of rheumatoid arthritis.

The use of Auranofin is increasing as the number of people having arthritis is increasing. This can driveauranofin marketas it is effective and is reported to exhibit less serious side effects as compared to other drugs that are used for treating arthritis.

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Increasing Demand for Auranofin Owing to Rising Arthritis Demographics

According to CDC reports, arthritis is still a serious health crisis in the U.S. and it is a global epidemic as well. Recent estimates showed that nearly 91 million Americans might have arthritis (37%), including one- third of those aged bwtween18 to 64 plus 300,000 children approximately. The underlying reasons for the increasing population with arthritis are obesity, lack of physical activity, Vitamin D deficiency and others. Also, Arthritis is rising in Europe, Latin America and in Middle East Africa and reasons being sedentary lifestyle and in some cases, heredity. The growing population with arthritis is anticipated to fuel the Auranofin market as it is less severe than the other drugs that serve the same purpose.

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The Auranofin market is rising because of the growing arthritis population and it is expected to grow in the coming years. The key players of Auranofin include Ferro Pfanstiehl Laboratories, Inc.,Prometheus laboratories inc, JOHNSON MATTHEY INC, Lek Pharmaceuticals d.d, Medichem SA and Company Overview ofLonza Group Ltd and others. Apart from them, more industrialists and manufacturers are showing a keen interest in the Auranofin as the demand for the auranofin, due to the rising population with arthritis is growing and is expected to escalate until and unless people dont practice healthy lifestyle and engage themselves in physical activities.

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Auranofin Market Status And Forecast 2027, By Players, Types And Applications - Market Research Sheets

Beloved Maine childrens singer Rick Charette and his Bubblegum Band played their 29th annual holiday concert at St. Josephs College earlier this month. It was a sold-out show, standing room only. As always, the price of admission was a new, unwrapped toy for a child in need.

Its likely to be Charettes final public performance ever.

Health challenges are forcing the 72-year-old author of Alligator in the Elevator and I Love Mud off the stage. But he doesnt want to make a big deal of it.

Id like to have people thinking of the music when they think of me, rather than my physical condition, Charette said. Thats why Im downplaying it.

He hinted at his retirement back in 2018, and while Charette is reluctant to talk about specifics, he said a combination of arthritis, a nagging shoulder injury and a touch of Parkinsons disease are making it difficult to perform his energetic shows. Charette would rather stop while hes still at the top of his game, rather than fizzle out and fade away.

I knew I should have said something about it being the last one, but I just couldnt bring myself to do it, Charette said. It would have been just too sad.

For now, hes telling people who want to book him to call back in the spring, when he might feel better. Charettte knows thats not likely, though.

Im ever hopeful but still accepting that, at some point, some things are the way they are, he said.

In the meantime, Charette can look back on an exceptional 35-year career of writing, singing and making children happy.

Charette grew up in Westbrook. When he graduated from Cheverus High School in 1965, music was already a big part of his life.

Pete Seeger was my hero in terms of what he could do to have the whole audience in the palm of his hand, singing along, Charette said over a cup of coffee at his kitchen table in Windham.

He also admired Bob Dylans songwriting.

While earning a degree in English at the University of Southern Maine, Charette found moderate local success as a folksinger, wielding an acoustic guitar, dulcimers and the occasional banjo. He played the bar and coffeehouse circuit and opened for better-known acts such as Tom Rush.

He wasnt always happy, though.

Playing for adults, I was a nervous wreck, Charette said. It was painful. Then, I played a little bit for kids, and it was a whole different vibe. I seemed to relax and be comfortable.

He knew hed found his niche.

Singing with kids meant he did not have to play in smoky bars anymore where the music was secondary to drinking and gabbing. Kids didnt yell requests for Neil Young all night, either.

I liked the hours a lot better, Charette said.

Bubble Gum was the first childrens song he wrote. Kids immediately latched on to its gentle, bouncing cadence and quirky lyrics: I dont like frog legs cause they smell like feet. You can take away the liver. Give me something sweet Bubble gum, bubble gum. Lots of fun with my bubble gum.

By 1983, Charette had recorded an albums worth of original material. He also scored a distribution deal with Activity Records.

When the record came out, it gave me credibility as a performer for kids, he said.

The company passed on his second batch of songs in 1985. They thought Charettes tunes werent educational enough. They wanted more colors and numbers.

At that juncture, Charette and Roy Clark, his piano player and arranger, hatched a plan. They both mortgaged their homes and started their own company, Pine Point Records. Their first release was the album Alligator in the Elevator.

That went on to sell several hundred thousand copies, Clark said.

Charettes best-known song, I Love Mud, appeared on that record.

All I have to do is sing, Mud, mud, I love mud, and everyone finishes the rest of the chorus, Charette said. And its usually the grown-ups singing loudest.

Clark said its Charettes ability to listen to kids, to take their interests seriously, that makes him a good songwriter. Instead of deciding what a child should be singing, he finds out what kids want to sing about.

Thats special. Thats unique, Clark said.

All told, Pine Point Records released 11 albums by Charette. The latest came in 2016.

With a hit childrens record, Charette was soon playing concerts and teaching school songwriting workshops across the country. Many of Charettes his best-loved songs include hand motions or sign language to help keep wee ones engaged. Skunk, bear and alligator puppets also played prominent roles in his performances.

Its beautiful pandemonium, said bassist Mike Burd of Industry. Burds played in the Bubblegum Band for about three years. Rick is a totally humble, gentle, self-effacing, completely transparent, honest guy. The kids fall all over him and follow him all around. The parents do the same thing and, in many cases, the parents parents did the same thing. He has this multigenerational audience. Everybody knows all the words to every song.

Charette has always shied away from politics or broad moralizing in his songs, focusing instead on warmth, fun and singability.

I just want it to be a happy time for them, he said. I think it makes a difference for kids, later in life just knowing someone cares for them giving them that time to play.

Its been a good life for Charette. Hes a happily married father of three and grandfather of two. Hes a longtime resident of Windham, living in an immaculate condo with access to Sebago Lake. Recently, however, hes started to feel his age.

My 60s were good, Charette said. But it seems like when I hit 70, I hit a wall.

Thats when he had a bicycle accident. Charette broke his collarbone and a few ribs, going down hard on a hidden curb.

The bones healed, but his shoulder has never been the same, making it hard to play the guitar. Charette also has arthritis and Parkinsons disease which hes opening up about for the first time.

Ive been reluctant to put that out there in public, he said. Its just the beginning stages and sometimes, when people know something like that about you, they start treating you differently.

He doesnt want that. Charettes early symptoms are manifesting mostly in tight muscles. They make it hard to move around. His feet often feel leaden, immobile.

I wouldnt want to present that onstage. You want kids dancing around, he said. In my mind, in my head, Im still right there. But physically, its just too difficult.

Looking ahead, Charette dreams of hiking when the weather gets nice again. He also imagines days when he might feel well enough to volunteer singing with children, stuck in the hospital. Hes still thinking up songs, too. Charette recently wrote one about Windham and gave it to a local schoolteacher.

Some days are better than others, and when they are, I try to make the most of them, Charette said.

He thinks about his musical legacy, pondering what its meant to himself and the thousands of children hes sung songs with.

Thats something Ive wondered, Charette said. Will this just be time that was taken up? Will they really remember any of it?

As news of his retirement spreads, hes getting his answer.

Cards, letters and Facebook messages are starting to pour in. People tell him about the impact his music had on their lives and now on their childrens lives.

He performed at my school all the time. I had Ricks records on my Christmas list in the 80s when I was a kid, said Heather Hilton, who grew up in Limington. Last year his downloads were on my sons wish list.

Hilton said her 5-year-old son especially likes Charettes epic song Where Do My Sneakers Go at Night? Hiltons mother, an elementary school teacher, still plays Charettes songs in her classroom and said her pre-K students still love them.

One card Charette received this month reads: From my birthday party in kindergarten, to Baxters first concert, youve made us smile throughout the years. Thank you for your wonderful gift of music. Your songs will live on. You will be missed.

It came with a smiling family portrait and was signed, Allyson, Baxter and Tristan.

After his final concert, one little girl waited in line to meet Charette. When it was her turn, she handed him a crinkled drawing of a snowman. It was signed, in pencil, From Athena.

I dont think its sunk in, yet, Charette said, looking at the drawing and the card. Sometimes, I beat myself up. I wish I could do more. Then, I have to remind myself to feel good about the things Ive already done.

Clark thinks Charettes music will be around long after both of them are gone. He points out that I Love Mud and Alligator in the Elevator are so familiar in the kid world, that many people mistake them for traditional folk songs in the public domain.

That seems to suit Charette just fine.

If I had to sum up the whole thing, Im just so gratified that Ive had this run, this experience, Charette said. Its always been the words and the music and the kids.

This story appears through a media sharing agreement with Bangor Daily News.

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'Your Songs Will Live On. You Will Be Missed.' Rick Charette Leaves The Stage - Maine Public

Insulin resistance is independently associated with body mass index (BMI) and synovitis in rheumatoid arthritis patients, shows new research published in Arthritis and Rheumatology.

Led by Ronan H. Mullan of the Trinity Centre for Health Science in Dublin, Ireland, researchers wrote that the findings, which were published December 16, suggest a link between glucose levels and rheumatoid arthritis (RA) inflammation.

RA and type 2 diabetes mellitus (T2MD) share many of the same characteristics. Both are powered by abnormal glucose metabolism and both are associated with insulin resistance and adverse cardiovascular disease outcomes.

In this study, researchers recruited 92 rheumatoid arthritis patients (mean age 59, 66% female) who were assessed for insulin resistance, BMI and rheumatoid arthritis disease activity. Researchers found thatglucose transporters GLUT1 and GLUT4 were heightened in the synovial tissues of rheumatoid arthritis patients, but not in those of osteoarthritis patients. And, GLUT1 was present in increased levels within all layers of the RA synovium. This suggests an independent association between insulin resistance (particularly with obesity) and the degree of RA disease activity and synovitis.

RELATED:Diabetes and RA: Explaining the Similarities

This data provides direct evidence that insulin resistant pathways are preferentially expressed within inflamed tissues in RA. And, they suggest a potential mechanism by which the reprogramming of glucose handling through differential GLUT expression favors the perpetuation of inflammation, researchers wrote.

METFORMIN

Taking metformin, a first-line treatment for type 2 diabetes mellitus, was shown to reduce inflammation in synovial tissue of at least five patients by decreasing the spontaneous production of IL-6, IL-8 and MCP-1 in synovial cells and fibroblasts.

We confirmed that metformin treatment increased the phosphorylation of AMPK and reduced the expression of GLUT1 from synovial fibroblasts. Furthermore, we demonstrated that metformin is capable of altering the cellular metabolic activity. This is consistent with recent studies suggesting metformin promotes resolution of inflammation through altered cellular metabolic activity, researchers wrote.

THE FINDINGS

REFERENCE: Lorna Gallagher Sian Cregan Monika Biniecka, et al. "Insulin Resistant Pathways are associated with Disease Activity in Rheumatoid Arthritis and are Subject to Disease Modification through Metabolic Reprogramming; A Potential Novel Therapeutic Approach," Arthritis and Rheumatolology. Dec. 16, 2019. https://doi.org/10.1002/art.41190

See more here:
Insulin Resistance Linked to Rheumatoid Arthritis Flares - Rheumatology Network