StemCell Therapy

This article was originally published here

Arthritis Rheumatol. 2021 Dec 20. doi: 10.1002/art.42044. Online ahead of print.

ABSTRACT

OBJECTIVE: To investigate levels and possible extramucosal formation of secretory immunoglobulins, including anti-citrullinated protein antibodies (ACPA), in rheumatoid arthritis (RA).

METHODS: Three patient groups were studied: i) ACPA-positive patients with musculoskeletal pain without clinical arthritis, ii) recent-onset RA, and iii) established RA. In baseline serum (i and ii) and paired synovial fluid samples (iii), we analyzed total secretory IgA (TSIgA), total secretory IgM (TSIgM), free secretory component (SC), and SC ACPA. Extramucosal formation of SC ACPA was investigated by pre-incubating RA sera and affinity-purified ACPA with recombinant free SC.

RESULTS: Compared to healthy controls, serum levels of TSIgA and TSIgM were increased both in early RA and at-risk patients (p<0.05). Early RA patients with elevated total secretory immunoglobulins had significantly higher disease activity during 3-year follow-up compared to those without increased levels. At-risk patients developing arthritis during follow-up (39/82) had higher baseline TSIgA levels compared to those who did not (p=0.041). In established RA, TSIgA and TSIgM levels were higher in serum than in synovial fluid (p<0.001), but SC ACPA adjusted for total secretory immunoglobulin concentration were higher in synovial fluid (p<0.001). Pre-incubation with recombinant free SC yielded increased SC ACPA reactivity in sera as well as in affinity-purified IgA and IgM ACPA preparations.

CONCLUSION: Circulating secretory immunoglobulins are elevated before and at RA onset. In the presence of free SC, secretory immunoglobulins may form outside the mucosa, and SC ACPA are enriched in RA joints. These findings shed important new light on the mucosal connection in RA development.

PMID:34927393 | DOI:10.1002/art.42044

Originally posted here:
Extramucosal formation and prognostic value of secretory antibodies in rheumatoid arthritis - DocWire News

Dublin, Dec. 17, 2021 (GLOBE NEWSWIRE) -- The "Global Rheumatoid Arthritis Market (2021 Edition) - Analysis By Drug Type (NSAIDs, DMARDs, Corticosteroids, Others), Treatment, Diagnosis, By Region, By Country: Market Insights and Forecast with Impact of COVID-19 (2021-2026)" report has been added to ResearchAndMarkets.com's offering.

The Global Rheumatoid Arthritis Market was valued at USD 24.46 Billion in the year 2020

Globally, the market for rheumatoid arthritis is increasing rapidly and the major factors that drive the growth of rheumatoid arthritis is the increasing aging population. Furthermore, some evidence suggests that people who smoke are at an increased risk of developing rheumatoid arthritis.

DMARDs segment is expected to hold significant share in Rheumatoid Arthritis Market on the back of increasing prevalence of rheumatoid arthritis incidences across the globe, the launch of the therapeutic agents, and the favorable reimbursement policies for the high-cost treatment products. These are the major factors propelling the growth of the market.

Americas region dominated the global Rheumatoid Arthritis market and led the industry in 2020 owing to presence of large patient base and availability of well-developed infrastructure, rising awareness regarding disease treatment, growing geriatric population, and high adoption of biopharmaceuticals for treatment.

There is also an increase in funds provided to academic research institutions and individual researchers that is expected to boost the market growth. Moreover, various initiatives by international bodies, such as WHO and NIH for the prevention and treatment of chronic disorders, such as cardiovascular diseases, Rheumatoid Arthritis and cancer are anticipated to facilitate the growth of the market.

The report tracks competitive developments, strategies, mergers and acquisitions and new product development.

The companies analysed in the report include

Merck KGaA

Sanofi

Eli Lilly Company

Amgen Inc

Bristol-Mayor Squibb

F. Hoffman-La Roche Ltd.

Johnson & Johnson

Cipla

Pfizer

Galapagos NV

Gilead Sciences

Key Topics Covered:

1. Report Scope and Methodology

1. Report scope & Methodology1.1 Scope of the Report1.2 Research Methodology1.3 Executive Summary

2. Strategic Recommendations

3. Rheumatoid Arthritis Market: Product Outlook

4. Global Rheumatoid Arthritis Market: Sizing and Forecast4.1 Global Rheumatoid Arthritis Market Size, By Value, Year 2016-20264.2 Impact of COVID-19 on Global Rheumatoid Arthritis Market

5. Global Rheumatoid Arthritis Market Segmentation - By Drug Type, By Treatment, By Diagnosis5.1 Competitive Scenario of Global Rheumatoid Arthritis Market: By Drug Type5.1.1 NSAID (non-steroidal anti-inflammatory drugs) - Market Size and Forecast (2016-2026)5.1.2 DMARD'S (Disease-modifying anti-rheumatic drug) - Market Size and Forecast (2016-2026)5.1.3 Corticosteroids- Market Size and Forecast (2016-2026)5.1.4 Others - Market Size and Forecast (2016-2026)5.2 Competitive Scenario of Global Rheumatoid Arthritis Market: By Treatment5.2.1 Tendon Repair - Market Size and Forecast (2016-2026)5.2.2 Joint Fusion- Market Size and Forecast (2016-2026)5.2.3 Joint Replacement- Market Size and Forecast (2016-2026)5.2.4 Others - Market Size and Forecast (2016-2026)5.3 Competitive Scenario of Global Rheumatoid Arthritis Market: By Diagnosis5.3.1 CRP (Creative Protein Test) - Market Size and Forecast (2016-2026)5.3.2 ESR (Erythrocyte Sedimentation Rate)- Market Size and Forecast (2016-2026)5.3.3 Others - Market Size and Forecast (2016-2026)

6. Global Rheumatoid Arthritis Market: Regional Analysis6.1 Competitive Scenario of Global Rheumatoid Arthritis Market: By Region

7. Americas Rheumatoid Arthritis Market: Segmentation (By Drug Type, By Treatment, By Diagnosis)7.1 Americas Rheumatoid Arthritis Market: Size and Forecast (2016-2026), By Value7.2 Americas Rheumatoid Arthritis Market - Prominent Companies7.3 Market Segmentation By Drug Type (DMARD's, NSAID, Corticosteroid, Others)7.4 Market Segmentation By Treatment (Tendon Repair, Joint Fusion, Joint Replacement and Others)7.5 Market Segmentation By Diagnosis (CRP, ESR and Others)7.6 Americas Rheumatoid Arthritis Market: Country Analysis7.7 Market Opportunity Chart of Americas Rheumatoid Arthritis Market - By Country, By Value, 20267.8 Competitive Scenario of Americas Rheumatoid Arthritis Market: By Country7.9 United States Rheumatoid Arthritis Market: Size and Forecast (2016-2026), By Value7.10 United States Rheumatoid Arthritis Market Segmentation - By Drug Type, By Treatment, By Diagnosis (2016-2026)7.11 Canada Rheumatoid Arthritis Market: Size and Forecast (2016-2026), By Value7.12 Canada Rheumatoid Arthritis Market Segmentation - By Drug Type, By Treatment, By Diagnosis (2016-2026)

8. Europe Rheumatoid Arthritis Market: Segmentation (By Drug Type, By Treatment, By Diagnosis)

9. Asia Pacific Rheumatoid Arthritis Market: Segmentation (By Drug Type, By Treatment, By Diagnosis)

10. Global Rheumatoid Arthritis Market Dynamics10.1 Drivers10.2 Restraints10.3 Trends

11. Market Attractiveness11.1 Market Attractiveness Chart of Global Rheumatoid Arthritis Market - By Drug Type, 202611.2 Market Attractiveness Chart of Global Rheumatoid Arthritis Market - By Treatment, 202611.3 Market Attractiveness Chart of Global Rheumatoid Arthritis Market - By Diagnosis, 202611.4 Market Attractiveness Chart of Global Rheumatoid Arthritis Market - By Region, 2026

12. Competitive Landscape12.1 Product Pipeline of Leading Rheumatoid Arthritis Companies12.2 Market Share Analysis

13. Company Analysis

Story continues

For more information about this report visit https://www.researchandmarkets.com/r/r5fx0l

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Global Rheumatoid Arthritis Market Report 2021: Market Insights and Forecast with Impact of COVID-19, 2016-2026 - Yahoo Eurosport UK

When you move, you might sometimes hear your joints crack. This is known as crepitus, Latin for "rattle," as perHealthline. These little pops might either give you relief, make you feel mildly uncomfortable, or inspire no sensation at all. However, hearing all the cracking might leave you concerned about the health of your joints. After all, surely these sounds aren't normal. But, orthopedic surgeon Kim L. Stearns, MD, told Cleaveland Clinic, "It's a normal, common occurrence."

You probably noticed that the older you get, the more of these types of noises you hear. There's a reason for that. "The older you get, the more noise your joints can make, because some of your cartilage wears away as part of the normal aging process," Dr. Stearns said. "Then these surfaces get a little rougher and so you get more noise as they rub against each other." While some joint cracking is normal and no cause for concern, you should contact a doctor in some cases. Read on to determine when the snap, crackle, and pop might indicate a problem.

There's some good news if you're worried about cracking joints causing arthritis. Healthline reported that it does not cause arthritis to crack your knuckles or other joints. Instead, that belief is merely an old wives' tale.

When should you worry about your joint cracking? "As long as it's not painful, joint noise is OK," Dr. Kim L. Stearns told Cleaveland Clinic. "If there's pain, you may have an injury then that requires treatment."Rehab Orthopedic Medicine reported that snapping and crackling could be a sign of arthritis, which is part of the normal aging process. Arthritis, and the joint noises that occur because of it, can be painful. The sounds you hear might indicate your bones are grinding against each other if your cartilage has worn away. When you feel joint pain in conjunction with your joints cracking, you should see your doctor to treat the underlying condition.

If you don't feel pain when your joints crack, chances are you don't have to worry about arthritis just yet. According to Healthline, the sounds you hear can result from your muscles moving. Additionally, the joint cracking might occur when cavities or bubbles form in your synovial fluid, which contains oxygen, nitrogen, and carbon dioxide to help provide cushioning for your bones. When those bubbles or cavities pop, then you hear cracking.

According to Cleveland Clinic, if you notice popping sounds while you're doing repetitive exercises, it could be a sign your muscles are tight. Dr. Kim L. Stearns recommended gentle stretching to help loosen up your tight muscles. If you hear more cracking joints than you'd like, and you're not concerned that it's due to arthritis, there is a solution to help lessen the amount of noise you hear. "We say motion is lotion the more you move, the more your body lubricates itself," Dr. Stearns noted. "When you've been sitting or lying around, fluid in the joints doesn't move. The more active you are, the more your joints lubricate themselves." Grab a yoga mat and get into the habit of stretching regularly throughout the day.

Read more:
What Does It Mean When Your Joints Keep Cracking? - The List

As the COVID-19 pandemic continues, people who are hospitalized with the virus have a variety of treatments to help them battle it. But misinformation is widespread, and thats caused some confusion about these treatment options. To get a clearer idea of what treatments hospitals are using and which ones theyre not we spoke with critical care physician Joseph Khabbaza, MD.

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services.Policy

Treatment options for people with COVID-19 have improved greatly since the beginning of the pandemic. While they do not guarantee a quicker recovery, they may help minimize the severity of the infection and get you back to health.

The anti-viral drug remdesivir was originally developed in 2009 as a potential treatment for hepatitis Candrespiratory syncytial virus (RSV). The drug was also used to treat a number of people during various Ebola outbreaks in recent years. And its been tested as a treatment for other coronaviruses like Middle East Respiratory Syndrome (MERS)and SARS.

The FDA (Food and Drug Administration) granted an emergency use authorization (EUA) of remdesivir for people with COVID-19 in the spring of 2020, and later, fully approved it after studies showed the drug could shorten recovery time for people. Its typically reserved for use with patients with cases requiring supplemental oxygen who are early enough in their illness that blocking virus replication could help minimize the severity of their course, says Dr. Khabbaza.

A pair of anti-inflammatory drugs have recently been granted EUAs by the FDA for use in people hospitalized with COVID-19.

The drug tocilizumab was granted an EUA by the FDA in June 2021 for use in certain people with COVID-19. The drug is a monoclonal antibody that, according to the FDA, reduces inflammation by blocking the interleukin-6 receptor.

In other words, the drug doesnt target the virus but does reduce inflammation caused by the virus by blocking one of the markers that drive inflammation. The drug is already used as a prescription medication for inflammatory conditions like rheumatoid arthritis.

Another drug, baricitinib, has also been granted an EUA by the FDA. Known as a janus kinase inhibitor, the drug blocks a specific group of enzymes that minimizes inflammation through a different pathway than tocilizumab. It has previously been FDA-approved for use in people with moderate-to-severe active rheumatoid arthritis.

Originally only given an EUA for use in combination with Remdesivir, baricitinib received an additional EUA that allows it to be administered on its own.

The steroid dexamethasone, typically used to treat inflammation associated with conditions like asthma and arthritis, was granted an EUA by the FDA to use in a combination with other drugs to treat severe cases of COVID-19.

Dexamethasone blunts the intensity of the inflammatory response our immune system makes when trying to fight COVID-19, says Dr. Khabbaza. Often, this inflammatory response is what drives severity of illness and studies have shown that minimizing it decreases the severity of disease in some patients.

A study showed a lower 28-day mortality rate for those who received the steroid as part of their treatment, but its not recommended for those with more moderate cases.

People with severe cases of COVID-19 pneumonia might require a breathing tube or ventilators for help maintaining oxygen levels. Being placed on a ventilator is one of the most extreme measures when it comes to treatment, but its necessary because people with severe cases are unable to maintain oxygen levels on their own.

While the mortality rate of those placed on ventilators is higher than those who dont require a ventilator, many people survive and eventually have the ventilator removed. But, Dr. Khabbaza notes, being put on a ventilator can cause other issues that require additional recovery time, too.

Being on a ventilator is quite uncomfortable because a tube is placed in the back of your throat and into the main windpipe that leads to our lungs, he says.

This process, Dr. Khabbaza adds, requires a fair amount of sedation for patients so they can safely tolerate the tube, which leads to more potential complications. Sedation in ICU patients can lead to profound muscle weakness that can often accompany an ICU stay and require a longer time of rehabilitation once off of the ventilator, he says.Additionally, being on a ventilator brings an increased risk of resistant bacterial pneumonia developing and trauma to our vocal cords or trachea if kept in too long.

Since the onset of the pandemic, a few alleged treatments have gained traction, often promoted by dubious claims across social media platforms.

The drug hydroxychloroquine received a lot of attention at the beginning of the pandemic as a possible way to treat COVID-19. At one time used as an anti-malarial drug, its currently used to treat lupus and rheumatoid arthritis. Despite those early suggestions, hydroxychloroquine is not used to treat COVID-19.

Overall, hydroxychloroquine is a safe drug. However, in extensive studies, it has never been shown to be helpful in fighting COVID-19 and that is the main reason it should not be used, says Dr. Khabbaza.

The risk of certain side effects makes hydroxychloroquinea less than ideal choice for the treatmentof COVID-19. The most concerning one is torsades de pointes, a type ofventricular tachycardiawhere your heart beats so fast that your blood pressure plummets and the heart cant pump enough oxygen through your body.

Other side effects include the risk of interference with other prescription medications and causing gastrointestinal issues. It was enough that in November 2020, the National Institute of Health issued a statement saying it had formally concluded that the drug provides no clinical benefit to hospitalized patients.

Another drug that hasgained attention from misinformationon the internet is ivermectin. There is a prescription version for humans that comes in oral and topical forms, but this is only used forparasitic roundworm infections likeascariasis,head liceandrosacea,and in far lower and safer doses than being suggested inappropriately for COVD-19.

A different version of this particular drug is in formulations that arent meant for consumption by humans but, rather, used to prevent heartworm disease and other parasites in horses and cows in the concentrated veterinary forms.

While both have been the subject of speculation by misinformed social media participants, neither are nor should be used as a treatment for COVID-19. Those higher doses can be very toxic for humans, Dr. Khabbaza says, and that can lead to severe side effects.

Some of those side-effects stemming from large doses include:

This medication is intended to treat parasites, not viruses, Dr. Khabbaza adds. While one study out of Egypt claimed to show the drugs effectiveness against COVID-19, Dr. Khabbaza points out that not all studies are created equally. Several other studies that are of a higher standard refute the claims its effective, he says.

The best way to protect yourself and to drastically reduce the risk of hospitalization from COVID-19 is to get vaccinated, Dr. Khabbaza says. All of the data weve gotten about the available, approved COVID-19 vaccines is that theyre highly effective in preventing serious illness from the virus, he points out.

While there have been breakthrough cases in people who are fully vaccinated, having the vaccine has greatly reduced the severity of the virus. No vaccine is ever perfect in completely preventing illness, Dr. Khabbaza says. But they do offer you immense protection against severe cases. The number of hospitalizations for vaccinated patients due to COVID-19 is incredibly low.

The bottom line: Get vaccinated and avoid social media for treatment advice.

Here is the original post:
Whats Used To Treat People Who Are Hospitalized With COVID-19 and Whats Not - Health Essentials from Cleveland Clinic

For example, he said, suppose a teenage patient goes to the doctor with telltale symptoms, such as hearing voices. If the doctor uses a new name for the diagnosis, Dr. Carpenter said, you can almost hear the parents saying, Didnt that used to be called schizophrenia?

This may also be the wrong moment to tinker with the name, Dr. Carpenter added. Scientists are reworking the clinical definition of schizophrenia, including focusing more on brain mechanisms, not just psychological symptoms, and viewing it more as a syndrome than as a single disease. These changes could be reflected in future revisions of the D.S.M., and it may not make sense to rename the disorder before this happens.

Even some mental health professionals who work to counter its stigma are skeptical of the renaming effort.

We absolutely agree that language is extremely important, said Lisa Dailey, the director of the Treatment Advocacy Center, which supports people with severe mental illness, but added that pushing for a name change is not an effective use of limited resources.

The best way to destigmatize schizophrenia, Ms. Dailey said, is to develop better medications that work for more people.

While other countries, including Japan and South Korea, have recently adopted new names for schizophrenia, Dr. Meshalom-Gately and Dr. Keshavan acknowledged that they need more of a consensus among scientists and clinicians in the United States.

There is precedent for rethinking mental health terminology, they note. The illness once known as manic depression was successfully relabeled bipolar disorder in 1980. Mental retardation became intellectual disability in 2013. And the categories for autism were changed in the most recent version of the psychiatric diagnostic manual, after years of advocacy.

Even if the Consumer Advisory Board succeeds in convincing the authors of the next diagnostic manual to change the name, it is not going to be enough to reduce stigma and discrimination, Dr. Mesholam-Gately said. There also needs to be public education campaigns that go along with that, to really explain what the condition is and the treatments that are available for it.

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Schizophrenia Still Carries a Stigma. Will Changing the Name Help? - newsconcerns

Pune, Maharashtra, India, December 17 2021 (Wiredrelease) MarketResearch.Biz :An overview of the market segment, size, share, sectional analysis, and revenue forecast, as well as a complete analysis, are included in the Rheumatoid Arthritis Drugs Market study. It looks at market factors, industry trends, market dynamics, and the strengths and weaknesses of the top competitors. It also includes details on sales channels, distributors, traders, and dealers, as well as research findings and conclusions, an appendix, and data sources. The research document goes into great detail about product launch events, growth drivers, challenges, and investment opportunities.

Book Your Sample Report @https://marketresearch.biz/report/rheumatoid-arthritis-drugs-market/request-sample

The study examines market competition, constraints, revenue predictions, opportunities, shifting trends, and industry-validated data in depth. The study begins with an overview of the industrial chain structure before delving into the upstream in greater depth. TheRheumatoid Arthritis Drugsmarket research study provides crucial statistics on the current state of the industry and serves as a valuable source of guidance and direction for businesses and individuals interested in the market. The study can aid in better understanding the market and planning for business expansion by offering an inside and out assessment of new rivals or existing organizations in the market.

The study examines market competitiveness among the top companies, as well as their biographies, market prices, and channel characteristics. A thorough market analysis considers a number of factors, ranging from a countrys population and business cycles to market-specific microeconomic ramifications. In terms of regional competitive advantage and the competitive landscape of significant enterprises, the study discovered a shift in market paradigms. Players have employed a range of tactics to increaseRheumatoid Arthritis Drugs market penetration and improve their positions, the following are some key players:

>

The market research report divides theRheumatoid Arthritis Drugs market into applications, Typeand market share . This study covers details the cost structure analysis and market growth factor of the industry. This report also sheds light on the fastest growing segments of the market and various factors that drives growth for such segments.

Rheumatoid Arthritis Drugs Market Segmentation Overview:-

distribution channel

drug class

Because the Covid-19 eruption has had such a broad impact on businesses, it is becoming increasingly important to understand the implications of all collaborations. With this in mind, we conducted extensive and one-of-a-kind research on the market impact of Covid-19. The following is a link to the Covid-19 study report:https://marketresearch.biz/report/rheumatoid-arthritis-drugs-market/covid-19-impact

The key features of the market research report Rheumatoid Arthritis Drugs are as follows:

Rheumatoid Arthritis Drugs Market Segmentation

Display all Rheumatoid Arthritis Drugs market data, including width

Market trends, development, and potential for promotion

Status of Competition, Circulation of Manufacturing Capacity, Sales Location, and Product Type

Market Research, Distributors/Merchandisers, and Marketing

Market risks and difficulties in the future

You can ask questions about the study or express your concerns about it here:https://marketresearch.biz/report/rheumatoid-arthritis-drugs-market/#inquiry

Finally, the analysis highlights the performance of the Rheumatoid Arthritis Drugsmarket sectors key elements and application components in each regional industry. Similarly, stratified guidance on the list of significant actors operating within each regional economy informs the regional economys competitive dynamics. This enables a thorough and in-depth examination of the overall business Rheumatoid Arthritis Drugsmarket. In addition, the report includes global Rheumatoid Arthritis Drugsmarket industry forecasts for each object, geography, and application sector for the years 2022-2031.

Historical year: 2015-2020

Base year: 2021

Forecast period: 2022 to 2031

Table of contents for Market Report Rheumatoid Arthritis Drugs:

1: Rheumatoid Arthritis Drugs market Industry Overview

2: The Global Economic Impact on the Rheumatoid Arthritis Drugs market Industry

3: Global Market Competition for Industry Producers

4: Global Productions and Revenue (Value) by Region

5: Global Supplies (Production), Consumption, Export, Import, and Geographical Distribution

6: Global Manufacturing, Revenue (Value), Price Trend, Product Type

7: Global Market Analysis by Application

8: Rheumatoid Arthritis Drugs Market Pricing Analysis

9: The Market Chain, Sourcing Strategy, and Downstream Buyers

10: Key policies and strategies of distributors/suppliers/traders

11: Key Marketing Strategy Analysis of Market Vendors

12: Market Influencing Factors Analysis

13: Rheumatoid Arthritis Drugs Market Prediction

Click here for the full INDEX, including data, facts, figures, tables and more:https://marketresearch.biz/report/rheumatoid-arthritis-drugs-market/#toc

Key Questions Answered in theRheumatoid Arthritis DrugsMarket Report

What are the main market drivers and restraints right now? What impact will future drives and restraints have?

What are the present markets main drivers and restraints? What effect will drivers and restraints have in the future?

What are the key global market effects of the COVID-19 pandemic?

What is the growth rate of the global market? What will be the growth tendency in the future?

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Rheumatoid Arthritis Drugs Market To Develop With Increased Global Emphasis On Industrialization - Digital Journal

Abatacept is also approved for adults with moderate to severe rheumatoid arthritis, active psoriatic arthritis, and moderate to severe polyarticular juvenile idiopathic arthritis for children 2 years of age and older.

The FDA approved abatacept (Orencia; Bristol Myers Squibb) for the prophylaxis, or prevention, of acute graft versus host disease (aGVHD) in combination with a calcineurin inhibitor and methotrexate for individuals 2 years of age or older undergoing hematopoietic stem cell transplantation (HSCT) from a matched or 1 allele-mismatched unrelated donor.

Orencia is the first FDA-approved therapy to prevent aGVHD following hematopoietic stem cell transplant, a potentially life-threatening complication that can pose a comparatively higher risk to racial and ethnic minority populations in the US due to difficulty finding appropriately matched donors, said Tina Deignan, PhD, senior vice president of US Immunology at Bristol Myers Squibb, in a press release.

Allogeneic HSCT is a treatment for hematological diseases that involves the infusion of hematopoietic stem cells, which includes donor T-cells, a type of white blood cell that recognizes and destroys foreign invaders and damaged or cancerous cells in the body.

The aGVHD occurs when the donor T-cells recognize an individuals healthy cells and begins attacking healthy tissues and organs.

Abatacept binds to and modulates protein targets involved in costimulation, which would inhibit T-cell activation. There is no known relationship between these biological response markers to the mechanisms by abatacepts clinical effects.

Abatacept has other indications for adults with moderate to severe rheumatoid arthritis, active psoriatic arthritis, and moderate to severe polyarticular juvenile idiopathic arthritis for children 2 years of age and older.

The approval is based on results from the phase 2 GVHD-1 trial, also known as ABA2, that evaluated abatacept when added to a regimen of a calcineurin inhibitor (cyclosporine or tacrolimus) and methotrexate for prophylaxis of aGVHD in individuals undergoing HSCT, and a clinical study known as GVHD-2 using data from the Center for International Blood and Marrow Transplant Research.

The findings suggest abatacept could play an important role in preventing aGVHD in hematopoietic stem cell transplant, said Leslie Kean, MD, director of the Stem Cell Transplantation Center at Dana-Farber/Boston Children's Cancer and Blood Disorders Center, in the press release. From these results, providers may also have more confidence in expanding the donor pool to include unrelated matched or 1 allele-mismatched donors for patients in need.

The concomitant use of abatacept with other immunosuppressives is not recommended. Abatacept has been associated with an increased risk of infection with concomitant use with tumor necrosis factor antagonists, other biologic rheumatoid arthritis and psoriatic arthritis therapy, or Janus kinase inhibitors; hypersensitivity; increased risk of serious infections; interactions with immunizations; and increased risk of adverse events (AEs) when used in patients with chronic obstructive pulmonary disease.

The most common AEs in rheumatoid arthritis are headache, nasopharyngitis, nausea, and upper respiratory tract infection. Common AEs for prophylaxis of aGVHD are acute kidney injury, anemia, cytomegalovirus (CMV) reactivation/CMV infection, hypertension, hypermagnesemia, pneumonia, and pyrexia.

Reference

US Food and Drug Administration approves Orencia (abatacept) in combination with a calcineurin inhibitor and methotrexate for the prevention of acute graft versus host disease (aGvHD). Businesswire. News release. December 15, 2021. Accessed December 16, 2021. https://www.businesswire.com/news/home/20211213006061/en

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FDA Approves Abatacept With Calcineurin Inhibitor for Prophylaxis of Acute Graft Versus Host Disease - Pharmacy Times

Whilst appearing on the Channel 4 show alongside Gyles, the 88-year-old actress learns a multitude of invaluable skills in the art of barging. This is made all the more impressive as she deals with crippling rheumatoid arthritis. Hiding the fact she has been suffering for fears that she might lose out on work, last year the actress finally revealed the extent of her illness.

In an interview with The Telegraph, Sheila said: Sometimes I cant move across the room.

Ive hidden the fact because of work, because I wouldnt get employed, because Im on the vulnerable list and all that.

But because its a hidden illness and a lot of people have got it Ive made a conscious decision to come clean about it.

The star was diagnosed with arthritis in 2017 after she felt agonising pain in her hand. In order to cope with initial symptoms, Sheila brought a splint, but it wasnt long before the other hand started to hurt too.

READ MORE:Bradley Walsh ticking time bomb health - star warned by doctors of 'silent killer'

Its a pain like you would not believe, she continued. One day I was reading a script and when I got up I couldnt move. My leg, my hip, my everything had gone into an appalling flare. I was trapped.

Due to her age, Sheila admitted that people often treat her with care, which used to irritate her, but now due to her arthritis, she is grateful that people remember that she is not only old, but she also aches a bit.

Speaking to The Sun more about her condition Sheila said: I have dodgy days but, on the whole, Im OK.

Worryingly however, it is not just her condition that weighs heavy on the mind of the actress, but her age in general.

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In an episode of Great Canal Journeys Sheila showed off her exercise regime to co-star Gyles, and in doing so tells him that she may only have a matter of months left to live.

"This wasn't to do with my illness, Sheila explained after the worrying confession. Although you can die of it and I do have to think about that but just at my age, youre unlikely to live many more years and that weighs heavily if, like me, youre greedy to learn new things.

In January of this year, Sheila admitted that filming The Discovery of Witches, a Sky fantasy drama, was made difficult due to a flare-up of the condition.

The NHS explains that rheumatoid arthritis is a long-term condition that causes pain, swelling and stiffness in the joints. Flare-ups are common, but make everyday activities increasingly difficult as symptoms become worse.

I had been ill before filming, Sheila said. So I was very cheeky and asked if they could lace me in very tightly instead so that I could get away with no corset.

I was so thin because I was going through flare-ups of the rheumatoid arthritis. Now Im fine. I have dodgy days but, on the whole, Im OK.

"On the days when I'm feeling all right, I get out and walk around - I've been doing a lot of it in lockdown."

The NHS explains that common symptoms of the condition include the following:

Rheumatoid arthritis is an autoimmune disease, meaning that cells in the immune system attack cells that line your joints by mistake. Over time, this can damage the joints, cartilage and nearby bone.

The NHS explains that it is not clear what triggers this problem, although there is sufficient evidence to suggest that you are at an increased risk if you are a woman, have a family history of rheumatoid arthritis or you smoke.

Currently there is no cure for arthritis, but early diagnosis and appropriate treatment enables many people with the condition to have periods of months or even years between flares.

The main treatment options include the following:

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Sheila Hancock health: Actress, 88, on illness she tried to hide - 'you can die of it' - Express

NEW YORK, Nov. 6, 2021 /PRNewswire/ -- Crowdsourcing has become an increasingly popular way to develop machine learning algorithms to address many clinical problems in a variety of illnesses. Today at the American College of Rheumatology (ACR) annual meeting, a multicenter team led by an investigator from Hospital for Special Surgery (HSS) presented the results from the RA2-DREAM Challenge, a crowdsourced effort focused on developing better methods to quantify joint damage in people with rheumatoid arthritis (RA).

HSS Logo (PRNewsfoto/Hospital for Special Surgery)

Damage in the joints of people with RA is currently measured by visual inspection and detailed scoring on radiographic images of small joints in the hands, wrists and feet. This includes both joint space narrowing (which indicates cartilage loss) and bone erosions (which indicates damage from invasion of the inflamed joint lining). The scoring system requires specially trained experts and is time-consuming and expensive. Finding an automated way to measure joint damage is important for both clinical research and for care of patients, according to the study's senior author, S. Louis Bridges, Jr., MD, PhD, physician-in-chief and chair of the Department of Medicine at HSS.

"If a machine-learning approach could provide a quick, accurate quantitative score estimating the degree of joint damage in hands and feet, it would greatly help clinical research," he said. "For example, researchers could analyze data from electronic health records and from genetic and other research assays to find biomarkers associated with progressive damage. Having to score all the images by visual inspection ourselves would be tedious, and outsourcing it is cost prohibitive."

"This approach could also aid rheumatologists by quickly assessing whether there is progression of damage over time, which would prompt a change in treatment to prevent further damage," he added. "This is really important in geographic areas where expert musculoskeletal radiologists are not available."

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For the challenge, Dr. Bridges and his collaborators partnered with Sage Bionetworks, a nonprofit organization that helps investigators create DREAM (Dialogue on Reverse Engineering Assessment and Methods) Challenges. These competitions are focused on the development of innovative artificial intelligence-based tools in the life sciences. The investigators sent out a call for submissions, with grant money providing prizes for the winning teams. Competitors were from a variety of fields, including computer scientists, computational biologists and physician-scientists; none were radiologists with expertise or training in reading radiographic images.

For the first part of the challenge, one set of images was provided to the teams, along with known scores that had been visually generated. These were used to train the algorithms. Additional sets of images were then provided so the competitors could test and refine the tools they had developed. In the final round, a third set of images was given without scores, and competitors estimated the amount of joint space narrowing and erosions. Submissions were judged according to which most closely replicated the gold-standard visually generated scores. There were 26 teams that submitted algorithms and 16 final submissions. In total, competitors were given 674 sets of images from 562 different RA patients, all of whom had participated in prior National Institutes of Health-funded research studies led by Dr. Bridges. In the end, four teams were named top performers.

For the DREAM Challenge organizers, it was important that any scoring system developed through the project be freely available rather than proprietary, so that it could be used by investigators and clinicians at no cost. "Part of the appeal of this collaboration was that everything is in the public domain," Dr. Bridges said.

Dr. Bridges explained that additional research and development of computational methods are needed before the tools can be broadly used, but the current research demonstrates that this type of approach is feasible. "We still need to refine the algorithms, but we're much closer to our goal than we were before the Challenge," he concluded.

About HSS

HSS is the world's leading academic medical center focused on musculoskeletal health. At its core is Hospital for Special Surgery, nationally ranked No. 1 in orthopedics (for the 12th consecutive year), No. 4 in rheumatology by U.S. News & World Report (2021-2022), and the best pediatric orthopedic hospital in NY, NJ and CT by U.S. News & World Report "Best Children's Hospitals" list (2021-2022). HSS is ranked world #1 in orthopedics by Newsweek (2021-2022). Founded in 1863, the Hospital has the lowest complication and readmission rates in the nation for orthopedics, and among the lowest infection rates. HSS was the first in New York State to receive Magnet Recognition for Excellence in Nursing Service from the American Nurses Credentialing Center five consecutive times. The global standard total knee replacement was developed at HSS in 1969. An affiliate of Weill Cornell Medical College, HSS has a main campus in New York City and facilities in New Jersey, Connecticut and in the Long Island and Westchester County regions of New York State, as well as in Florida. In addition to patient care, HSS leads the field in research, innovation and education. The HSS Research Institute comprises 20 laboratories and 300 staff members focused on leading the advancement of musculoskeletal health through prevention of degeneration, tissue repair and tissue regeneration. The HSS Global Innovation Institute was formed in 2016 to realize the potential of new drugs, therapeutics and devices. The HSS Education Institute is a trusted leader in advancing musculoskeletal knowledge and research for physicians, nurses, allied health professionals, academic trainees, and consumers in more than 130 countries. The institution is collaborating with medical centers and other organizations to advance the quality and value of musculoskeletal care and to make world-class HSS care more widely accessible nationally and internationally. http://www.hss.edu.

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Researchers Present Global Effort to Develop Machine Learning Tools for Automated Assessment of Radiographic Damage in Rheumatoid Arthritis - Yahoo...

Remote classes such as yoga, Pilates, and tai chi are beneficial for people with musculoskeletal problems such as osteoarthritis (OA), rheumatoid arthritis (RA), and osteoporosis, according to research presented at the American College of Rheumatology 2021 annual meeting.

After attending biweekly 60-minute low-intensity Zoom fitness classes at six-week increments, participants improved physically and became more socially active, say researchers at the Hospital for Special Surgery (HSS) in New York City.

RELATED: Whats Your Arthritis Lifestyle Type?

Out of the 355 people assessed (among a total of 6,779 participants), 161 self-reported a musculoskeletal condition. Affecting the joints, bones, or muscles, musculoskeletal conditions include inflammatory arthritis and other chronic conditions associated with pain, functional limitations, and disability.

Participants were mostly female, older than 60, and white. That group reported that with any level of participation at every six-week virtual exercise session, they achieved:

Those who said they attended twice a week or more for six weeks reported even more improvement:

Live remote exercise programs offer a two-way interactive experience: participants connect to a video conference or meeting remotely with a computer, smartphone, or tablet device, usually from their own home. During the class, people may have the opportunity to talk with others and get personal feedback from the instructor, who can see and hear them via the devices camera and microphone.

HSS offered a remote, live class that had to be taken at a scheduled time but provided direct interaction with the instructor and other students. Unlike prerecorded classes online (often free) that allow you to participate whenever you choose, the live classes allow for interaction and professional oversight. Online or on-demand fitness classes are similar to the one-way classes offered via recording on a videotape or DVD.

RELATED: 6 Simple Yoga Poses for Psoriatic Arthritis

According to the Centers for Disease Control (CDC), loneliness affects more than one-third of adults age 45 and and up and nearly one-fourth of adults age 65 and older. (Obviously, the COVID-19 pandemic made human connection vastly more difficult.) There are many health risks associated with social isolation, including dementia, mental health issues, and premature death.

A study published in June 2017 inQuality in Ageing and Older Adults found a strong connection between social isolation and loneliness and chronic musculoskeletal diseases. To work on that, the HSS research team built a social component into their exercise programs. We made sure our classes were structured to increase interactions with others. We promoted a dialogue before the class began so people could talk and catch up with each other. They said it helped promote social connections, says Titilayo Ologhobo, MPH, the director of outcomes and data analytics at HSS and the new studys author.

RELATED: Tai Chi Might Help Reduce Belly Fat in Middle-Aged and Older Adults

The team did not collect data comparing virtual and in-person classes, but the feedback they received was that people enjoyed the virtual program because of the time flexibility and the convenience of working out at home. Other barriers to exercise known to challenge people with arthritis and other conditions are physical accessibility, travel conditions, and pain with movement. Research published in Physical Therapy and Rehabilitation Journal found that people with osteoarthritis experienced the following obstacles to exercising regularly at in-person classes.

Ologhobo stresses that you shouldnt start any new exercise regimen before consulting with your healthcare provider. Your doctor can help you assess whether a given program is appropriate for your level of fitness and health. If you have moderate or severe disease, you may want to check in with a physical therapist who can evaluate the safety and efficacy of a given program for you and suggest specific resources. Here are some virtual sites that offer gentle exercise. Consider a trial class or trial membership before you make a financial commitment. If none of these work for you, ask your healthcare provider or physical therapist for suggestions.

The takeaway for rheumatologists and others who care for people with painful musculoskeletal conditions appears to be to encourage participation in these types of classes. Amid the uncertainties caused by the pandemic, shifting to virtual programming provided older adults with musculoskeletal conditions continued access to effective community programs and reduced the negative impact of isolation. Implementation of virtual online exercise programs can be successful when assessing the needs of your target audience, considering potential barriers to program participation, and tailoring virtual programs to meet patients specific needs, Ologhobo said in a press release.

RELATED:How Fitness Helps You Manage Chronic Disease

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Livestreaming Fitness Classes Can Improve Pain, Joint Stiffness, and Fatigue - Everyday Health

Ayurvedic diet  |  Photo Credit: iStock Images

When you have arthritis, your body is already in an inflammatory state. One is battling pain and other symptoms that if left unattended can cause other chronic conditions such as obesity, heart disease and diabetes. Here's what Ayurveda says about pro-inflammatory foods and things to avoid.

The name for Rheumatoid Arthritis in Ayurvedic texts is "Amavata". Ayurvedic texts prescribe specific diet and treatment procedures such as Virechanakarma.

As per a study that is published in the Journal of Research in Ayurveda, Amavata is a disease in which vitiation of Vata Dosha and accumulation of Ama take place in joint(s), and it simulates rheumatoid arthritis (RA) in modern parlance. Shamana (conservative) and Shodhana (biological purification of the body) treatments are advised in Ayurveda whereas anti-inflammatory, analgesics, steroids, and disease-modifying antirheumatic drugs are required for its management as per modern medicine, which is not free from side effects.

The study cites the case of a lady patient with Rheumatoid Arthritis. "As the patient did not get any relief with Shamana Chikitsa (ayurvedic or modern medicinal treatment), it was decided to go for Shodhana Chikitsa (Panchakarma). The patient underwent Virechanakarma (therapeutic purgation) as per indication mentioned in the classics of Ayurveda."

After a follow-up of 1 year, the patient was found free from almost all signs and symptoms of Amavata. The quality of life was improved significantly and the patient was enjoying a normal healthy life with no exacerbation.

Asper a report in PlanetAyurveda.com, along with the medicines, the patient must also observe pathya (dos and don't) to help the healing process.

What to eat and what to banish from your platter?

Planet Ayurveda prescribes the following dos and don'ts where diet is concerned.

Cereals to consume: Quinoa, buckwheat, brown rice, oats, little millet, corn, Kamut, wheatCereals to avoid: Barley, Rye, White rice

Fruits to consume: Apple, Banana, Cherry, Avocado, Peaches, pear, pomegranate, Sapodilla, apricot, blueberry, amlaFruits to be avoided: All citrus fruits like lemon, oranges, sweet lemon, etc, strawberry, mango, kiwi

Vegetables to be consumed: Ridge gourd, pumpkin, spinach, potato, drumstick, carrot, broccoli, onion, ginger, beetroot, bitter gourd, round gourd, mushroom, bottle gourd, kale zucchini, turnips, beans.Vegetables to avoid: Tomatoes, eggplant or brinjal, radish

Pulses to consume: All pulses and legumesPulses to avoid: None but limit the use of Black gram/kidney beans

Dairy products to consume: Occasionally or limited intake of ghee, skimmed milk (by adding turmeric) and low-fat yoghurtDairy products to avoid: All the other milk products

Oils to be consumed: Sunflower oil, ghee, olive oil, mustard oil, rice bran oilOil to avoid: Canola oil, Palm oil, coconut oil

Ayurveda bans all stale food, bakery products, fried foods, pickles, refined sugar, vinegar, packaged food, processed and junk foods, says PlanetAyurveda.com. It also cites Ayurvedic texts that layimportance upon weightloss to beat arthritis. Yoga and massage as well as pranayam are stressed upon. Avoid spices, stress, and drinking at least 8-10 glasses of water, says Planet Ayurveda.

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Foods that can worsen arthritis symptoms: Listen to Ayurveda-prescribed dos and don'ts - Times Now

There are also a number of factors which might make inflammation and pain worse. The main goals of arthritis treatments are to reduce symptoms and improve quality of life. Arthritis or other similar conditions that affect the joints, impacts more than 10 million people in the UK. People of all ages can suffer from the health issue, including children, though there are some modifiable risk factors that may help stave off the condition.

Arthritis is not a single disease, but instead a way of referring to joint pain or joint disease. There are more than 100 types of arthritis and related conditions.

Osteoarthritis and rheumatoid arthritis are the two most common types of arthritis.

Currently, the NHS notes that there is no cure for arthritis, but there are many treatments that can help slow it down.

There are also a number of factors that can increase your risk of developing the condition. If you have arthritis, your joints will most likely feel stiff and be hard to move, you may also find that the area around your joints may feel warm, look red or puffy.

READ MORE:The common mistake people make when showering that can be 'harmful' - pharmacist's warning

University Health says that incorporating foods high in omega-3 fatty acids, protein and fibre into your diet, may help reduce joint pain and inflammation.

Some foods can actually trigger inflammation, so if you have an arthritis diagnosis it may be worth cutting these down in yourdiet.

Itadds: On the other hand, there are certain foods you may want to avoid. Processed foods, food with added sugars and red meats may cause inflammation.

It suggests avoiding ice cream, fast food, cakes, bread and biscuits, as well as beef and pork.

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If you notice symptoms or are concerned about arthritis it is important to speak to your GP.

The NHS encourages those living with arthritis to eat a healthy and balanced diet and maintain a healthy weight.

They explain diets should consist of a variety of foods from all five food groups. These are fruit and vegetables, starchy foods, and meat, fish, eggs and beans.

The health body adds that you should include milk and dairy foods, and foods containing fat and sugar.

"Finding out whats causing your pain is key to finding the right treatment and self-help options, says Versus Arthritis (VA).

As well as causing pain and stiffness, inflammation can cause permanent damage to a joint, so starting effective treatment early on can help to minimise damage.

Its important to see a doctor if you get any new symptoms or if you have any trouble with drugs youre taking, VA adds.

Treatment for most arthritis aims to slow the condition's progress and minimise joint inflammation.

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Arthritis: Three of the 'worst foods' for causing inflammation - 'you may want to avoid' - Daily Express

Lisa Hilinski| Special to the Erie Times-News

With just 10 minutes of exercise a day, you can slow pains of aging

Apparently less than 10 minutes of walking a day may keep arthritis away. Buzz60's Maria Mercedes Galuppo has more.

Buzz60

As colder weather arrives, many arthritic patients are convinced the lower temperatures and varying barometric pressures can increase their pain.

Having more than a decade of experience training clients with arthritis, I find this to be true.

With that said, scientists have yet to provide actual evidence that lower temperatures or varying humidity make arthritis worse. Yet, they seem to believe their patients on some levelbecause the connectionbetween weather and arthritis has been studied a lot.

If youre someone whosearthritis tends to ignite at this time of year, here are some things we can tell you about your condition:

While everyone isunique, the consensus is that arthritis symptoms lessen with various types of movement. Positive outcomes have been shown with flexibility training andstrength training, as well as cardiovascular training.

Lisa Hilinski: Exercise can increase productivity at the workplace with happier, healthier employees

The worst thing you can do as someone with arthritis is sit around. While this holds true for any population, its particularly true for those with arthritis.

Sitting creates stiff joints, which results in more pain when its time to move around. You want to create more blood flow to your joints and keep those joints happy.

Regular exercise will be valuable for those with arthritis, but you dont need to be super structured.

Some days youre going to wake up feeling like a million bucks, and other days youll wake up feeling like a truck hit you. Its important to read your body and do what its telling you.

More Lisa Hilinski: Train your body to go in all directions to avoid injury, losing range of motion

On the days when youre feeling your worst, do something low impact, like general cardiovascular training. On the days when your body is feeling good, do some lower-impact strength training.

Use some lighter dumbbells and resistance bands, and give yourself a full body workout.

Flexibility training can be done every day and should be performed both statically and dynamically.

Overall, move your body to keep it happy this winter,and let your body tell you what it needs.

Lisa Hilinski is owner of Premier Personal Training.

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Lisa Hilinski: What to know about effects on arthritis as colder temperatures arrive - GoErie.com

Arthritis is a painful and debilitating condition that affects many millions of people in the UK.

While there is medication to help control the pain there are also many simple lifestyle and dietary changes that can help to manage it.

One natural remedy is contained in a very cheap and tasty herbal tea that could help ease joint pain, the Express reports.

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Arthritis is caused by swelling around the joints and damage to the cartilage that keeps joints moving.

Osteoarthritis is the most common type of arthritis in the UK.

It tends to affect people over the age of 40 and women in particular.

Anyone who feels they may have arthritis os advised to speak to their GP about possible treatments available.

But dietary changes and cutting out foods known to cause inflammation, as well as eating more foods with anti-inflammatory properties, are often recommended.

People who suffer from the condition may also be advised to lose weight as being heavier can put more strain on your joints.

So, could a 13p tea help to reduce arthritis pain?

Rosehip tea is a herbal tea made from the rose plant and has a floral but tart taste.

Rosehip was used by ancient civilisations as a natural remedy for many conditions, ranging from toothache to rabies.

Today rosehip extract is linked to many health benefits, including boosting the immune system, reducing inflammation and improving heart health.

Is it something that can help people manage arthritis?

Rosehip contains two substances believed to reduce joint inflammation and pain - polyphenols and anthocyanins.

Polyphenols are compounds found in plants and plant-based foods that are high in antioxidants.

Anthocyanins are a type of antioxidant known for their purple colour. It is the substance which gives blueberries, aubergines, red cabbages and blackberries their vibrant colours.

Rosehip is also high in vitamin C, which is noted for its antioxidant properties, as well as boosting the functioning of the immune system.

Research has been carried out on rosehips healthy properties.

One four-month study of 100 people with osteoarthritis, found taking five grams of rosehip extract every day, saw reduced pain for 65 per cent of those who took part.

Studies have also noted rosehip can have a positive effect on weight loss, which can help manage joint pain and arthritis.

A cup of rosehip tea is just three calories, so it makes for a great low-calorie alternative to sugary drinks. It is also caffeine free.

The evidence that is currently available as to its benefits has focused on studies where participants take a more concentrated rosehip extract.

But rosehip tea is a very cheap and easily available alternative.

You can pick up a bag of 20 teabags from Holland & Barrett for just 2.59.

If youre adventurous you could even try making some yourself by brewing your own dried rosehips in boiling water.

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The 13p herbal tea that could help ease the pain caused by arthritis - Coventry Live

There are many simple lifestyle changes you can make to help manage arthritis. Could this herbal tea reduce inflammation and help with painful joints?

Arthritis is a very common condition caused by swelling around your joints and damage to the cartilage that keeps your joints moving.

The most common type of arthritis in the UK is osteoarthritis, which is most common in people over the age of 40, and most prevalent in women.

If you suspect you might have arthritis, its best to speak to your GP about possible treatments available for you.

Changes to your diet, such as cutting out foods known to cause inflammation, and eating more foods with anti-inflammatory properties, are often recommended to people with arthritis.

Some people with arthritis will also be advised to lose weight or maintain a healthy body weight, as being heavier can put more strain on your joints.

Could this 13p tea help to reduce arthritis pain?

READ MORE:Pfizer booster shot: Expect 'arthralgias' to be likely

The evidence available at the moment has focused on studies where participants take a more concentrated rosehip extract.

However, if you prefer to drink rosehip tea you can pick up a bag of 20 teabags for just 2.59 from Holland & Barrett.

Alternatively, you can try brewing your own dried rosehips in boiling water.

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Arthritis diet: The 13p tea to reduce painful symptoms of arthritis - Express

Excruciating arthritis symptoms can be decreased with this simple but powerful tea from South Asia.

Over 10 million people in the UK suffer from arthritis, a condition that can affect those of all ages.

Arthritis is a common health condition which causes chronic pain in your joints. It damages joints, bones and can impact other body parts depending on the type.

Osteoarthritis is the most common variant of the condition, accounting for 9 million cases and usually, but not exclusively, develops after the age of 40.

It initially affects the smooth cartilage lining of the joint, then once the cartilage lining starts to roughen and thin out, the tendons and ligaments have to work harder causing excruciating pain.

There are two types of arthritis, osteoarthritis and rheumatoid. While osteoarthritis is caused by day-to-day wear-and-tear, rheumatoid arthritis is when your body's immune system attacks the joint capsule, which houses all parts of the joint responsible for seamless movement.

The attacks can eventually result in the cartilage being totally destroyed, leaving the sufferer with painful bone-on-bone movement.

Inflammation in the body can make symptoms of both types significantly worse, but drinking this tea could significantly lessen your pain.

In a study published on the US National Library of Medicine National Institutes of Health, it found that an active compound in turmeric, called curcumin, was effective in reducing pain in patients with osteoarthritis.

Not only this, but they found patients experienced no side effects after drinking the tea.

Though it can't restore joints and cartilage to pre-arthritis condition, it reduces swelling responsible for much of the pain associated with the condition.

Turmeric tea has also been shown to relieve period pains of women, relaxing blood vessels around the uterus.

The active ingredient that reduces swelling in turmeric, curcumin, makes up only 3-5 percent of the spice. Therefore, those looking for a higher dose are recommend to take a daily curcumin supplement of 200 to 1000mg, that contains 95 percent curcuminoids.

Turmeric has long been used in South and South East Asian cooking and medicine. Numerous studies are underway exploring its medical potential in the West.

The NHS highlights these main signs as symptoms of arthritis:

If you are experiencing any of these symptoms, contact your healthcare provider.

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Arthritis: Experts hail powerful Asian tea that can dramatically decrease pain - Birmingham Live

TUESDAY, Nov. 2, 2021 (HealthDay News) -- Air pollution is associated with increased rheumatoid arthritis (RA) disease severity, according to a study published in the October issue of Rheumatology.

Giovanni Adami, M.D., Ph.D., from the University of Verona in Italy, and colleagues collected longitudinal data of patients affected by RA and the daily concentrations of air pollutants in the Verona area to examine the correlation between RA flares and air pollution in a case-crossover study. Exposure to pollutants was compared in the 30- and 60-day periods preceding an arthritic flare relative to the 30- and 60-day exposure preceding a low-disease activity visit.

Data were included for 888 RA patients with 3,396 follow-up visits. The researchers identified an exposure-response relationship between air pollutant concentration and the risk for having abnormal C-reactive protein (CRP) levels. The risk for having CRP levels 5 mg/L were increased for patients exposed to higher concentrations of air pollutants. In the 60-day period preceding a flare, concentrations of carbon monoxide, nitric oxide, nitrogen dioxide, oxides of nitrogen, particulate matter with a diameter of 2.5 m or less, and ozone were higher.

"The excessive risk was seen even at very low levels of exposure, even below the proposed threshold for the protection of human health," the authors write. "Our study has important and direct consequences. In order to reduce the burden of RA, public and environmental health policy makers should aim to diminish gaseous and particulate matter emissions to a larger extent than currently recommended."

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Air Pollution Linked to Increased Rheumatoid Arthritis Severity - HealthDay News

Rheumatoid arthritis is a chronic condition in which the bodys immune system attacks its own tissues. The condition typically causes swelling, stiffness, and pain in the joints. However, it may also affect other areas of the body, including the cardiovascular system, kidneys, skin, and eyes.

For some, rheumatoid arthritis (RA) symptoms can significantly affect their ability to carry out day-to-day tasks. In these situations, the person may qualify for disability benefits.

This article discusses when RA is a disability, how to know if a person living with RA qualifies for benefits, and how to claim them. We also provide tips on how to manage the symptoms of RA.

RA is a progressive condition, meaning that it will worsen over time. The pace at which the disease progresses will depend on multiple factors, including:

In a 2008 study of RA and work disability in the United States, 35% of people stopped working within 10 years of their initial RA diagnosis.

According to the Global Healthy Living Foundation, to qualify for disability benefits, a person would need to show that they are unable to work for a year or that working may result in death.

The Social Security Administration (SSA) considers RA a disability if a person meets the following eligibility criteria:

The SSA calculates work credits based on the total amount a person earns each year. According to the SSA, in 2021, a person can receive one credit for every $1,470 of earned income for a maximum of four credits per year.

Though the amount needed per credit often increases each year, a person can accumulate credits at different points in their life. They will not disappear if a person stops working for several years.

Disability benefits, more commonly known as Social Security Disability Income (SSDI), are available for qualified individuals. To qualify, a person must have worked and paid into social security for a number of years.

The SSA outlines the number of years a person needs to have worked to qualify for SSDI. The number of years varies based on the age of the person. According to the SSA, people 3142 years old need to have earned 20 credits in the 5 years before becoming disabled.

However, a person aged 62 years or older needs to have earned 40 credits in the 10 years before becoming disabled.

According to the SSAs monthly statistical snapshot, the average monthly benefit in June 2021 for people under 65 years old with a disability was $1,310.

The SSA classifies RA under inflammatory arthritis.

According to the SSA, to qualify for SSDI, a person living with RA needs to meet one or more of the following criteria:

In determining benefits, the SSA will also look at a persons ability to sustain work based on their Social Securitys Medical-Vocational Guidelines.

The guidelines use the Residual Functional Capacity (RFC) to determine how much work a person living with RA can reasonably carry out. The RFC classification outlines four broad categories based on the physical demands of a persons work. They include:

If a person cannot complete their expected work based on their disability and experience level, they may qualify for full benefits. However, a person who can complete light or sedentary work may not be eligible if they can work in a sedentary position.

The RFC also takes into account the following factors to determine if a person should receive SSDI:

People may apply for SSDI benefits online here or by calling 800-772-1213.

The SSA provides an Adult Disability Checklist to help people determine what they need before applying for disability benefits. They provide one checklist for completing an application online and another for completing an application over the phone.

The checklist details the documents and information a person needs to apply for benefits. Some of the information a person will need includes:

There is no cure for RA, but there are ways to manage its symptoms and slow its progression. The goal of most treatment plans is to:

Some standard treatment options include:

A person should talk to their doctor if they notice worsening or continued symptoms. Working closely with a doctor is important for managing symptoms and reducing the severity of RA.

RA is a chronic disease that primarily affects the joints but can also affect other parts of the body. The condition can progress to the point that a person finds it difficult or impossible to maintain their occupation.

The SSA classifies RA as a type of inflammatory arthritis. A person with RA may qualify for benefits if they become unable to work. A person must document that they meet the Social Security criteria for disability before receiving any benefits.

Although there is no cure for RA, a person can manage the condition with medications, therapies, and appropriate lifestyle changes.

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Is rheumatoid arthritis a disability? Benefits and more - Medical News Today

The Virginia woman says she and her whole family got the vaccine as soon as it was available. She's immunocompromised and susceptible to getting really sick if she caught Covid-19. She has lupus and rheumatoid arthritis and it is these diseases that add an extra layer to her frustration and anger.

"We did our part to preserve ourselves, our community, in trying to help battle this by getting vaccinated," Melendez said. "It's just unfortunate that the ignorance and laziness, for lack of better words, of other people who avoided taking the vaccine and ended up in the hospital with Covid, now has to impact me."

The antibody treatment blocks an inflammatory protein called IL-6 that causes damage in rheumatoid arthritis. That same protein plays a role in some of the serious symptoms in people with severe Covid-19 infections.

In the United States, supplies of several dose levels of this medicine have been out of stock since last Monday.

A life saver and life changer

For patients with Covid-19, the drug can be lifesaving. For patients with rheumatoid arthritis, like Melendez, it can be life-altering.

"It has restored my ability to have a fully functioning life," Melendez said. "Before it, it was so bad that simple things like brushing my teeth, combing my hair, opening a bottle of water, unfastening a pair of jeans, going to a restaurant, feeding myself were all challenges. Standing up and walking was hard. That's how bad my RA gets and I'm only 47."

Without the medication, even for a month, people can suffer debilitating flare-ups.

"It isn't easy to switch drugs, especially when you're on a serious drug like Actemra," Taylor said. "You surely don't want to be bouncing around."

Genetech is expanding manufacturing

On Thursday, Genentech sent a notice to customers saying it was "working as urgently as possible to expedite replenishments and increase manufacturing capacity and supply wherever possible."

The company said the medicine should be available for distribution starting Monday, August 30, but "given continued tight supply, Genentech anticipates additional intermittent periods of stockouts in the months ahead if the pandemic continues at the current pace."

A subcutaneous injectible form of Actemra that has not been authorized to treat Covid-19 is still available for patients with rheumatoid arthritis. Snow suggested patients ask their doctors about it. It's unclear if insurance would cover it.

And for hospitalized Covid-19 patients, there are some alternatives if Actemra is not available.

"We also strongly encourage Roche to facilitate technology transfer and knowledge and data sharing to broaden access to this important treatment," the WHO said in its statement.

More pandemic shortages

"All it takes is a little spike in demand and we have problems," Fox said.

Because of the uncertainty of surges, some facilities also hoarded some medication. Genentech recently said it would not take orders back, and that should cut down on hoarding, Fox said.

"The same as any other manufacturer, they're going to make enough for what they think they need for the year. Nobody wants to have extra inventory sitting around," Ganio said.

Ganio said the American Society of Health System Pharmacists has also heard reports of shortages of in-line filters that are used with IV bags. There's been more demand for them due to the increasing use of the Regeneron antibody cocktail used to treat people with Covid-19.

"It's very frustrating. In shortage after shortage after shortage the manufacturer does not have a plan for when they can't supply product. It's often 'good luck, we're out,' " Fox said. "All decisions are made about the business first and unfortunately, there's no requirement to make anything, no matter how life saving it is."

"I know I can't be the only person who's sitting here today on edge," Melendez said. "I want to make sure they don't forget about us."

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Pandemic surge causes major shortage of a drug that treats rheumatoid arthritis and severe Covid-19 - CNN

Rheumatoid arthritis (RA) is a type of inflammatory arthritis and autoimmune disorder. People with RA have an increased risk of diabetes, while diabetes can also raise the risk of RA. Excessive inflammation, lifestyle factors, and genetics may be among the factors that connect the two conditions.

RA and diabetes also share several risk factors and causes, including certain medications.

This article discusses the link between RA and diabetes and explains how people can prevent and treat each of these conditions.

Although diabetes and RA share some similarities in terms of their causes and risk factors, they are very different conditions.

RA is an inflammatory autoimmune disease in which the bodys immune system mistakenly attacks healthy cells and tissue. It often causes inflammation in the joints of the hands, knees, or wrists. In some cases, it may affect the lungs, heart, eyes, or other organs throughout the body.

Type 2 diabetes is the most common form of diabetes. In a person living with the condition, the body either does not produce enough insulin or does not use it effectively. In either case, blood sugar levels will elevate.

The most likely connection between type 2 diabetes and RA involves inflammation and a buildup of cytokines known as tumor necrosis factor (TNF) in the body. The Arthritis Foundation notes that TNF plays a necessary role in wound healing by causing an inflammatory effect. However, it can be harmful when too much TNF is circulating in the body.

In RA, the immune systems attack on the joints causes TNF to build up in the body. In type 2 diabetes, fat cells mainly produce TNF, which can cause the body to develop insulin resistance over time. As a result, it is possible that the inflammation and TNF associated with RA could increase the risk of a person developing type 2 diabetes.

Other possible connections between RA and type 2 diabetes involve medications and lifestyle factors that can act as risk factors for both conditions.

Certain medications, such as corticosteroids, can increase the likelihood of developing type 2 diabetes. Also, RA might lead to a person having a more sedentary lifestyle, which is a risk factor for type 2 diabetes.

People living with type 1 diabetes may also be at higher risk of developing RA and vice versa.

The Global Healthy Living Foundation, a nonprofit organization, explains that type 1 diabetes is an autoimmune disorder in which the immune system mistakenly attacks insulin-producing cells. It notes that a person living with one autoimmune disorder has an increased chance of developing a second one at some point in their lifetime.

People living with RA may have an increased risk of developing type 2 diabetes. Researchers have found that people living with RA are 23% more likely to develop type 2 diabetes compared with the general population.

In a 2020 review, researchers noted that RA can negatively affect a persons insulin resistance, which can cause the body to develop more fat. They also reported that many people with RA who develop type 2 diabetes also have other risk factors, including obesity.

People living with RA may be more likely to develop type 1 diabetes, as both conditions are autoimmune disorders. A person who has an autoimmune condition is more likely to develop another one during their lifetime.

The Arthritis Foundation suggests that people over the age of 45 years get screenings for diabetes every 3 years, noting that this is particularly important for those living with RA.

Learn more about risk factors for type 2 diabetes.

People living with type 1 diabetes have a higher risk of developing RA. In part, this may be due to both conditions being autoimmune disorders. There also may be a genetic link between the two conditions research has shown that the gene PTPN22 is linked to both conditions.

Some researchers believe that the inflammation associated with type 2 diabetes triggers RA in people who are genetically predisposed. A 2014 study in Taiwan supports this theory, finding that living with type 2 diabetes increases the risk of RA in females.

It is unclear whether type 1 or 2 diabetes could make RA symptoms worse. However, similar lifestyle changes can help both conditions, including:

Doctors can help create an effective treatment plan for a person living with RA, diabetes, or both.

A doctor can recommend a combination of medications alongside self-care strategies to slow the progression of RA and prevent joint damage. The CDC says that possible strategies for people living with RA include:

Learn some tips for dealing with rheumatoid arthritis flare-ups here.

The Arthritis Foundation notes that treating a person living with RA and type 2 diabetes is not much different than treating a person living with RA alone. One of the most important aspects for a person living with both conditions is to get regular exercise to help prevent heart disease.

A doctor may recommend a combination of medications and lifestyle adjustments to manage diabetes. In some cases, a person may find that diet and exercise modifications are enough to control their blood sugar.

If a person cannot control their blood sugar with diet and exercise alone, a doctor may recommend medication. They may recommend drugs to help the body process sugar or prescribe insulin.

Read a review of therapies and lifestyle changes for diabetes here.

RA and diabetes share some similar features, and a person with one condition may have an increased risk of the other.

People living with type 1 diabetes may have an increased risk of RA, and vice versa, due to the connection between autoimmune disorders and genetics. The inflammation associated with type 2 diabetes may put individuals with this form of diabetes at higher risk of RA. RA can make a person more likely to develop type 2 diabetes by affecting their insulin resistance.

A person living with RA should get regular screenings and watch for warning signs of diabetes. A person with a diagnosis of type 2 diabetes should follow their doctors treatment advice.

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Rheumatoid arthritis and diabetes: Link, prevention, treatment - Medical News Today