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Archive for the ‘Blindness’ Category

‘Am I going to lose my eye?’: St. John’s star overcomes blindness – New York Post

Sunday, May 21st, 2017

Cradled in his fathers arms, overcome with tears streaming down his cheeks, Jeff Belge had two questions:

Am I going to lose my eye? Will I ever play baseball again?

Belge, 9 years old at the time, and his cousin were skipping stones when he accidentally was hit squarely in the right eye with a rock that had slipped from his cousins hand, shattering his cornea. His eye became deflated like a balloon, white puss oozing out of it.

Fast forward seven years later, Belge is at a hotel in Atlanta, rough-housing with teammates after a long day of summer league baseball games. One of the Syracuse natives teammates accidentally sticks his finger in the same right eye, undoing the two surgeries from the first incident, and rupturing the globe in his eye. It had become deflated again.

You have to prepare yourself that we may have to remove his eye, his mother Karen was told by one doctor.

Yet, here he is, two traumatic experiences later, still pitching, an integral part of one of the best baseball teams in St. Johns history, a 6-foot-5 southpaw who throws mid-90s heat and has a professional future.

Belge is legally blind in his right eye, which was saved. The freshman can only see some colors and outlines of objects, relying solely on the left eye, in which he has 20/25 vision. But he doesnt see it as a limitation. It has been that way since he was 9. Its who he is.

I find ways around it, said Belge, who wears protective glasses. It doesnt really bother me.

Its just me having a dream and just following it. Its a bump along the way I had to get over.

After the first incident, doctors couldnt tell him if baseball was going to be part of his future. He had to miss a month of school. He didnt bother asking after the first few times. He didnt need anyone to answer the question for him.

I just told myself I was going to play, Belge said. I got on the field as soon as I could.

He started the road back with his little league coach, who would hit him tennis balls in the outfield, so he could get used to using just the one eye without fear of hurting himself. Belge would spend hours with his dad at the local park, pitching and hitting, training himself like he was learning the sport from scratch. When he got back into games, nearly a year later, he didnt think about the eye.

His focus was that intense. The injury had given him big-time motivation, determination, to push through things, he said.

If anything was a challenge, his father Tom said, it was trying to slow him down.

Belge made the Henninger High School varsity as a seventh grader, was also a standout basketball player and played quarterback for a season. He made it onto major league scouts radar as a sophomore, after striking out 11 opposite Scott Blewett, a second-round pick in 2014.

Belge was nearly a top draft pick despite the second incident costing him most of the summer prior to his senior year of high school, depriving him of several notable showcases in front of scouts.

The Red Sox, Brewers and Royals all offered Belge significant money in the third round, according to his father, money they turned down. Still, the Red Sox drafted him in the 32nd round as a courtesy.

I certainly hope in two years hes a Red Sox, said Ray Fagnant, the Red Sox area scout who followed him in high school. Hes a kid you always root for. Nothing is ever going to scare him.

The family liked the idea of him attending St. Johns, believing the experience of living in New York City and continuing to develop was too good to pass up. That bond with the Queens school grew in the summer before his senior year, following the incident. Depressed he was going to miss the showcases and unable to do much of anything baseball-related for six weeks, Belge sunk into depression. He was being forced to relive the traumatic accident from his childhood. All the work he had put in, all the time he spent staring down adversity, felt like a waste.

It put me in a bad place mentally, he said.

Pitching coach Corey Muscara, his lead recruiter, made sure to stay in close contact with Belge. Muscara would call him almost daily and suggest goals making his bed, losing a pound of weight per week, finishing a book as a way for him to keep active. It wasnt forgotten when it came time to make a decision about his future. It set it in stone, Wow, this guy really has my best interest at heart, Belge recalled.

Though Belge said he isnt thrilled with his performance this year on the mound hes 3-3 with a 5.13 ERA in nine starts the southpaw has been an integral part to one of the best teams in program history, just three wins shy of the most in St. Johns history. He has been a weekend starter as a freshman for the nationally-ranked Red Storm, with freshman Nick Mondak missing almost the entire year due to arm trouble and Kevin Magee just returning from his own injury.

I dont know how he does it, Mondak said of his teammate pitching with vision in only one eye. Its amazing.

Belge doesnt see it that way. This always has been his goal: to play baseball at a high level, and one day reach the major leagues.

The two accidents didnt change that. He expects a lot of himself, and remains confident he can be a major factor for St. Johns (40-9) in next weeks Big East Tournament and the NCAA Tournament that follows. He already has overcome so much, a few poor outings wont do much to that belief.

He doesnt take anything for granted, Karen said. When you have setbacks and have things taken from you, a lot of kids wouldve crumbled. A lot of kids wouldnt say I can do this again, maybe be scared of the mound, be afraid to get hurt. Not Jeffrey.

Its made Jeffrey a much stronger-willed person. It wasnt going to own him, and it didnt.

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'Am I going to lose my eye?': St. John's star overcomes blindness - New York Post

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SEF Dallas raises close to $30000 toward eradicating curable blindness in India – Star Local Media

Sunday, May 21st, 2017

Sankara Eye Foundation (SEF)s Dallas Chapter organized their inaugural walkathon, a 5K Fun Run/Walk for Vision on May 13 at Myers Park and Event Center in McKinney.

The event brought over 1,200 registered participants including Mayor-Elect George Fuller and his wife, Maylee-Thomas Fuller.

The event included a variety of entertainment for people of all ages bounce houses, pony rides, slides, fun filled music by local radio host DJ Moody, food and beverage choices via food trucks and even a fast-beat, choreographed flash mob led by Sweta Rajesh.

Close to $30,000 was raised with sponsorships from a host of local businesses including diamond sponsors Saravanaa Bhavan and Texas Institute for Neurological disorders.

A campaign to Open 300 Eyes was the highlight of the event. With a $30 donation, a donor gifts vision to a blind person in one of the many SEF eye hospitals in India. The assembled crowd surpassed the target by donating funds to open 450 eyes, aided by Fuller, who pledged to open 50 eyes. Baylor Scott & White Medical Center, Centennial, based in Frisco, matched the contribution toward the first 100 eyes. Participants who pledged received an I opened an eye sticker.

Established in the Bay Area, SEF is a nonprofit organization that has been working for the past 12 years with the goal of eradicating curable blindness in India. SEF has currently established nine community hospitals as well as two city hospitals and will soon embark on two new hospital projects.

SEF provides free eye care for those unable to afford it, those members of the rural poor, and this accounts for 80 percent which is approximately 150,000 people per year of the surgeries performed at their hospitals. For information visit giftofvision.org.

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SEF Dallas raises close to $30000 toward eradicating curable blindness in India - Star Local Media

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Smaller Version of Skill Injectors & Color Blindness Support – MMORPG.com

Saturday, May 20th, 2017

The EVE Online site has been updated with the news that Skill Injectors are getting a new, smaller version in addition to the current one. The smaller Skill Injector will weigh in about 1/5th the size of the already-existing one and will, of course, come at a lower cost, perfect for newer and beginning players.

At the current time, Skill Injectors cost about 650M ISK, a cost prohibitive to new players. By adding the smaller injector, more players early in their time within EVE will have an opportunity to make use of them.

You can read the full blog post on the EVE Online site.

In other EVE news, color-blindness support is coming to the game!

[A]round 7.999% of EVE players are color blind, which is a considerable chunk. I am not one of those 7.999%, so it was particularly interesting, yet challenging, to work on this feature, mostly because I was at no point capable of estimating if I was finding any success. I guess that gave me a tiny taste of how it must feel to be colorblind.

You can read more about how support was designed here.

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The Doctor finally reveals his blindness in trailer for next week’s ‘Pyramid at the End of the World’ – DigitalSpy.com

Saturday, May 20th, 2017

Warning: this article contains spoilers from Doctor Who episode 'Extremis'.

After this week's confusing Doctor Who episode 'Extremis', it seems that the Doctor, Bill and Nardole are heading to more challenging terrain next week.

In a trailer for 'The Pyramid at the End of the World', we see the trio visit a 5,000-year-old pyramid.

Except there's a problem the structure was not there the previous day, and the creatures inside have been studying the people around it to arrive at that exact time.

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Related: Doctor Who series 10, episode 6: 8 HUGE questions and theories after watching 'Extremis'

Oh, and it looks like the Doctor may finally reveal the truth about his blindness, which would be good, eh Doctor?

Those shadow creatures from this week's episode are also back, and they seem to be as doomy as ever.

Meanwhile, 'Extremis' finally saw the return of fan favourite Missy after a series or so away from our screens.

BBC

Related: Doctor Who series 10, episode 6 review: 'Extremis' gets lost in the dark

We also learned what was inside the vault, in that the Doctor had actually been holding Missy inside the whole time a secret that was revealed within the first five minutes.

Doctor Who returns on BBC One next Saturday (May 27) with 'The Pyramid at the End of the World'.

Want up-to-the-minute entertainment news and features? Just hit 'Like' on our Digital Spy Facebook page and 'Follow' on our @digitalspy Twitter account and you're all set.

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The Doctor finally reveals his blindness in trailer for next week's 'Pyramid at the End of the World' - DigitalSpy.com

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An Experimental Gene Therapy Uses Viruses to Stop Age-Related … – Futurism

Saturday, May 20th, 2017

In Brief Researchers from Johns Hopkins Medicine in Maryland have discovered a rather unusual way to treat a severe form of age-related blindness. They found a virus inserted into the retina can be used to halt or even reverse the disease. A Unique Treatment

They say you dont fight fire with fire. However, researchers from Johns Hopkins Medicine in Maryland have found that sometimes a virus may be the best weapon against a disease.Their studyhas been publishedin The Lancet

The researchers werelooking for ways to treat a particular type ofage-related macular degeneration (AMD)known as a wet AMD. Its a rare and more severe form of the disease,affecting just 10 percent of all AMD patients, and it causes new blood vessels to grow under the retina, which then leak blood and fluid into the eye, leading to vision problems.

The researchers knewthey could halt and even reverse the condition by suppressing an overactive protein called vascular endothelial growth factor (VEGF). Other researchers had been able to do it with monthly eye injections, but this team was hoping to do it with just one injection.

The best way they found to do this was by using a common cold-like virus called AAV2 as a carrier of gene that activates the production of a differentprotein,sFLT01, tocounter VEGF.

In a preliminary trial involving 19 men and women 50 years old and above, the researchers injected the patients with a form of AAV2that was genetically engineered to penetrate retinal cells and deposit the gene. After the virus deposited the gene, the cells began secreting sFLT01 which bound to VEGF and prevented it from stimulating leakage and growth of abnormal blood vessels, explained a Johns Hopkins press release.

The clinical trial showed promising results, with the condition of four of the patients improving dramatically after just one viral injection. Two others saw some reduction in the fluid build up, and the treatment didnt produce any side effects in any patients. Even at the highest dose, the treatment was quite safe. We found there were almost no adverse reactions in our patients, said researcher Peter Campochiaro.

Of the patients that didnt respond, the researchers discovered that five naturally produced antibodies that would attack the AAV2 virus, rendering it unable to complete its gene depositing mission. They think these antibodies could be prevalent throughout the population, making it difficult to determine how effecting the treatment would actually be.

Nevertheless, this research is a step in the right direction, especially with AMD expected to affect almost 5.44 million people in the U.S. by 2050. This preliminary study is a small but promising step towards a new approach that will not only reduce doctor visits and the anxiety and discomfort associated with repeated injections in the eye, but may improve long-term outcomes, Campochiaro said.

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Face blindness test: Do you have the same condition as Brad Pitt? – Express.co.uk

Friday, May 19th, 2017

GETTY

The inability to recognise faces is a surprisingly common, but fairly unknown, condition.

Those who suffer have to use clothes, hairstyles, voice or walking manner to identify a person.

It means that they often remove themselves from social situations so that they dont embarrass or offend others.

Many people are unaware they are affected, and may just think they have a bad memory.

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Some people with face blindness struggle to recognise their family and friends, and this can have a negative impact on their lives."

Punit Shah

However a new simple test to diagnose face blindness has been presented in research published in the The Quarterly Journal of Experimental Psychology.

They looked at whether an online questionnaire could accurately reveal face recognition ability.

Punit Shah, lead study author and lecturer in psychology at Anglia Ruskin University, said: Some people with face blindness struggle to recognise their family and friends, and this can have a negative impact on their lives.

Face blindness has been recognised by the NHS since 2016 and it is important to establish how many people are affected in order that they receive the assistance they need.

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Little Geeta, three, and her younger brother Lukeshwar, one, suffer from severe skin condition epidermolysis bullosa - an inherited mutation that makes skin fragile.

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In the questionnaire, the participants were asked how much they agreed or disagreed with particular statements, such as I often mistake people I have met before for strangers or I sometimes find movies hard to follow because of difficulties recognising characters.

Shah explained: Psychologists interested in face blindness have been hesitant to use questionnaires, but our new study suggests that using a well-designed questionnaire is helpful in recognising the condition and is suitable to be used on a large scale.

We are now adapting this questionnaire as there is evidence that prosopagnosia exists in children. It could help to explain why some children struggle to make close friends, and the problem could be more acute in schools where uniforms are worn.

Early detection may be beneficial as training programmes to improve face recognition, which are known to work in adults, may be even more successful in children given that they have a more plastic brain. There is still a lot to learn about prosopagnosia, but this research into identifying the condition using questionnaires is hopefully a step in the right direction.

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One of the most well known sufferers of prosopagnosia is the actor Brad Pitt.

He has spoken in the past about how the condition makes him seem egotistical.

According to the NHS, the condition often affects people from birth.

They are unable to recognise family, friends and partners, and have to use other clues to identify them.

This can be difficult if a sufferer sees someone out of context, and can cause distress.

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Face blindness test: Do you have the same condition as Brad Pitt? - Express.co.uk

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Could eating a low GI diet prevent blindness as you get older … – Express.co.uk

Friday, May 19th, 2017

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New research has discovered that switching from a high-glycemic (GI) diet to a low-glycemic diet can stop the progression of age-related macular degeneration (AMD).

The study by Tufts University found that for the same amount of total carbohydrate, high GI foods release sugar into the bloodstream more rapidly than low GI foods.

This can affect your eyesight by causing damage to the retina.

High GI foods include potatoes, white bread and rice, while examples of low GI foods are whole grains, lentils and fruit.

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The researchers discovered that a high GI diet triggered the development of many features of AMD.

The researchers discovered that a high GI diet triggered the development of many features of AMD.

These included the loss of function of cells at the back of the eye, and of the cells that capture light.

However, eating a low GI diet did not.

Interestingly, switching from a high GI diet to a low GI diet could repair this damage to the retina.

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10 things to eat to live past 100

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Sheldon Rowan, scientist at Tufts University and lead study author, said: "We were genuinely surprised that the retinas from mice whose diets were switched from high- to low-glycemic index diets midway through the study were indistinguishable from those fed low-glycemic index diet throughout the study.

We hadn't anticipated that dietary change might repair the accumulated damage in the RPE so effectively.

Our experimental results suggest that switching from a high-glycemic diet to a low-glycemic one is beneficial to eye health in people that are heading towards developing AMD.

AMD happens gradually over time - in the early stages it causes blurred vision, while later on it can develop into blindness.

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There is currently no cure, making these new findings of particular interest.

The researchers also believe theyve found potential biomarkers of AMD which can be used to predict when a person is at risk for this disease.

Allen Taylor, scientist at Tufts University and senior study author, said: "Currently, there are no early biomarkers to anticipate the disease. Our findings show an interaction between dietary carbohydrates, the gut microbiome, specific biochemical molecules, and AMD features.

This work should lead to new approaches to understand, diagnose and treat early AMD - perhaps before it affects vision.

Already anticipated by our human epidemiologic studies, the findings imply that we can develop dietary interventions aimed at preventing the progression of AMD, a disease which impacts millions and costs billions worldwide.

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Scientists have reversed age-related blindness by deliberately … – ScienceAlert

Friday, May 19th, 2017

A small and preliminary clinical trial has found that injecting a common cold-like virus into the eyes of age-related macular degeneration (AMD) patients - one of the leading causes of blindness in the US - can halt and even reverse the progression of the disease.

The results will need to be replicated in a much larger group of patients, but the early signs suggest that a single injection of the specially engineered virus can kick the body's natural immune response into gear, and clear out the fluid that causes permanent vision loss.

The approach, trialled by researchers at Johns Hopkins Medicine in Maryland, targeted a protein called vascular endothelial growth factor (VEGF), which is overactive in people with wet AMD - a rare and more severe form of the disease, which causes new blood vessels to grow beneath the retina and leak blood and fluid into the eye.

This build-up of fluid causes permanent damage to light-sensitive retinal cells, prompting them to progressively die off, leaving blind spots in the centre of a person's vision. Wet AMD affects around 10 percent of all AMD patients.

While treatments do currently exist for wet AMD, they involve getting injections in the eye once every four weeks - and if you want to maintain the benefits, you have to keep up those monthly injections for the rest of your life.

Side effects of current medications include eye infections and a heightened risk of stroke.

What the team at Johns Hopkins has demonstrated in a handful of patients is that, in some cases, there could be a way to halt and even reverse the progression of wet AMD with a single injection.

"This preliminary study is a small but promising step towards a new approach that will not only reduce doctor visits and the anxiety and discomfort associated with repeated injections in the eye, but may improve long-term outcomes," says one of the team, Peter Campochiaro.

"[P]rolonged suppression of VEGF is needed to preserve vision, and that is difficult to achieve with repeated injections because life often gets in the way."

The phase 1 clinical trial involved 19 men and women, who were 50 years or older, with advanced wet AMD.

They were divided into five groups that received increasing doses of a viral vector called AAV2 - a common cold-like virus that's been genetically engineered to penetrate the patients' retinal cells and deposit a gene that prompts the production of a protein called sFLT01.

"After the virus deposited the gene, the cells began secreting sFLT01 which bound to VEGF and prevented it from stimulating leakage and growth of abnormal blood vessels," the team explains.

"The goal is for the retinal cells infected by the virus to produce enough sFLT01 to permanently stop the progression of AMD."

Previous research has shown that sFLT01 can inactivate VEGF, but until now, scientists had struggled to get the body to produce it on its own - instead, they've had to regularly inject VEGF-suppressing proteins to keep it at bay.

The first three groups were given the lowest doses of the AAV2 virus, and after they showed no negative side effects, the final two groups were given the maximum dose. No severe side effects were observed in either group.

"Even at the highest dose, the treatment was quite safe. We found there were almost no adverse reactions in our patients," says Campochiaro.

The 19 participants were all selected based on their lack of response to all other standard treatment options - eight of which were unlikely to respond even to their new treatment.

Of the remaining 11, four showed dramatic improvements after a single viral injection, with the amount of fluid in their eyes reducing from severe to "almost nothing", the team reports. Two more patients experienced a partial reduction in the amount of fluid in their eyes.

The remaining five patients weren't so lucky, experiencing no improvement in vision after the injection, but for good reason - the researchers realised that their bodies naturally produced antibodies that attack the AAV2 virus.

And therein lies the rub, because the researchers suspect that these natural antibodies could be widespread in the US at least, becauseadeno-associated viral infections - a relative of the AAV2 virus - are quite common.

It will take a much larger clinical trial to figure out if the almost 50-50 chance of success in this study is an accurate indication of how the wider population will respond to their new treatment, but it's a promising development.

With advanced age-related macular degeneration expected to increase fromapproximately 2.07 million Americans in 2010 to 5.44 million in 2050, treatment that works for only half of wet AMD patients could still change hundreds of thousands of lives.

The research has been published in The Lancet.

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Diabetes sufferers could REVERSE blindness with new drug – Express.co.uk

Friday, May 19th, 2017

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In rare cases of uncontrolled diabetes, sufferers can turn blind.

One the most common forms of diabetic eye disease is diabetic retinopathy.

Its caused by having higher than normal levels of blood glucose for a long period of time which can damage the small blood vessels within the retina.

These are the light-sensitive layer at the back of the eye that converts light into signals for the brain.

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A new drug has just been approved by the FDA to treat all forms of the diabetic eye disease.

Until recently, theres been no way to reverse it.

However, a drug has just been approved by the US Food and Drug Administration (FDA) to treat all forms of the diabetic eye disease.

Previously the drug, Lucentis, had been available for use in the US to manage patients with diabetic macular edema (DME), and was given the go-ahead for its use in the UK in 2013.

Now it can be used to treat diabetic retinopathy in patients with or without DME.

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People should be aware signs and symptoms of diabetes are not always obvious and the condition is often diagnosed during GP check ups.

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Sandra Horning, chief medical officer and head global product development at Genentech, the developers of Lucentis, said: "Diabetic retinopathy is the leading cause of vision loss among working-aged adults in the US between the ages of 20 and 74.

We are very pleased that Lucentis is now FDA-approved to treat retinopathy in people with and without DME.

Currently the main way to treat the condition is with laser eye surgery, which works by preventing fresh blood vessel growth and improving the nutrient and oxygen supply to the retina.

Prior to the FDAs approval, research compared Lucentis directly with laser surgery.

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In the study, the drug was shown to significantly improve diabetic retinopathy among the 300 patients who trialled it.

Its the first vascular endothelial growth factor (VEFG) inhibitor to be approved for treating all forms of diabetic retinopathy.

VEGF sends new blood vessels to help affected tissues, but this can actually make sight worse.

There are two ways vision loss due to diabetes can occur.

Either weak, abnormal blood vessels can develop on the surface of the retina, leaking fluid onto the centre of the eye, and blurring vision.

Alternatively, fluid can leak from the blood vessels into the central area of the retina that provides our central vision, and cause it to swell.

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Color blindness epidemic in NM – Albuquerque Journal

Friday, May 19th, 2017

.......... .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... ..........

While hanging out at A Better U, the word on the streets is that during UNMs search for a new head mens basketball coach not one black coach was included within the list of potential candidates. And furthermore, that no black administrators or faculty were even casually offered the opportunity to provide input within the selection process of a program manned more than 50 percent by African American students. Two questions were posed that merit mention: (1) Would this have occurred if there were more African Americans working within the UNM Athletics Department and/or mens basketball? (2) Is UNM, which still does not have a black person sitting on its board of regents, making greater efforts to eradicate institutional racism on its campus as the school promised following hazing incidents aimed at black students two years ago? Sorry, my bad, thats right, like the Bernalillo Democratic Party and the New Mexico State Democratic Party, youre color blind.

Has anyone noticed that a great amount of the ART project construction emphasis is near and around the Confederate monuments in Old Town? The same monuments that Mayor Richard Berry promised the Albuquerque African American community he would remove or modify over two years ago. And while some still insist these monuments represent New Mexicos heritage, the fact remains that this commemoration is sponsored by the Sons of Confederate Veterans (SCV), an organization that has been directly tied to the Ku Klux Klan and other white supremacist organizations throughout its history. Yet, when completed, ART will bring all visitors and residents of the state right to a commemoration of one of this nations most atrocious acts against humanity: slavery of black people. Oh, Im sorry, my bad, like Bernalillo Democratic Party, New Mexico State Democratic Party and the University of New Mexico, the Mayors Office and city of Albuquerque are also color blind.

With the APS 20162017 (school year) coming to a close over the next few weeks headlined by high school and middle school graduations, many in the African American community are interested in the plans of the APS Board (of Education) to address discriminatory disciplinary practices throughout the schools in the district prior to the beginning the next school year. Many groups, including Black Parents of New Mexico, have been urging the APS Board to look into the disproportionate number of as well as the severity of expulsions and suspensions administered to African American students.

Throughout the nation this practice is the catalyst of the prison pipeline that plagues the family and youth while deteriorating life at large for all of society.

This past February a more progressive mindset appeared to have been elected to the board, a mindset that should embrace the belief that everyone deserves a fair shot at a decent, fulfilling and economically secure life. However, I must note that traditionally progressives do not believe race is endemic to the American experience, and furthermore, there is not one black person sitting on the school board.

Oh, Im sorry, my bad, like the Bernalillo Democratic Party, the New Mexico State Democratic Party, the University of New Mexico, the Mayors Office and city of Albuquerque, and joining the list, APS, youre all so, so, color blind.

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Color blindness epidemic in NM - Albuquerque Journal

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Gene therapy infection can prevent blindness, research shows | The … – The Independent

Thursday, May 18th, 2017

A gene therapy that deliberately infects the eye with a virus can safely preserve vision in people affected by one of the leading causes of blindness, research has shown.

In a small preliminary study, scientists used an altered common cold-type virus to carry a repair gene that combats age-related macular degeneration (AMD).

The disease is marked by abnormal blood vessels that leak fluid into the central part of the retina, or macula.

After being injected into patients' eyes, the virus penetrated retinal cells and deposited the gene, which manufactured a therapeutic protein called FLT01.

Lead researcher Professor Peter Campochiaro, from Johns Hopkins University in the US, said: This preliminary study is a small but promising step towards a new approach that will not only reduce doctor visits and the anxiety and discomfort associated with repeated injections in the eye, but may improve long-term outcomes.

The Phase I clinical trial involved 19 men and women aged 50 and older with advanced wet AMD.

With the help of the gene, retinal cells were turned into factories making FLT01.

The scientists hope this will eliminate the need to administer repeated injections of the protein, which suppresses a natural growth-driving molecule called VEGF.

Prolonged suppression of VEGF is needed to preserve vision, and that is difficult to achieve with repeated injections because life often gets in the way, said Prof Campochiaro.

For safety and ethical reasons, the patient group consisted of people for whom standard approved treatments were highly unlikely to restore vision.

Only 11 patients stood any chance of fluid reduction. Of those, four showed dramatic improvements after the gene therapy. The amount of fluid in their eyes dropped from a severe level to almost nothing.

Two other patients experienced a partial reduction in the amount of fluid in their eyes.

The findings are reported in the latest issue of The Lancet medical journal.

Press Association

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Test could confirm if Brad Pitt does suffer from face blindness – The i … – iNews

Thursday, May 18th, 2017

A test has been developed that can identify people with the same inability to recognise faces that is thought to affect Brad Pitt.

Face blindness, or prosopagnosia, is thought to affect around one in 50 individuals including the Hollywood star who has talked about how it causes him to appear egotistical.

Sufferers have to rely on other clues to identity such as hair style, clothes, or speech. Sometimes people are so badly affected that they avoid social situations for fear of embarrassment or causing offence.

Psychologists interested in face blindness have been hesitant to use questionnaires, but our new study suggests that using a well-designed questionnaire is helpful in recognising the condition and is suitable to be used on a large scale.

Dr Punit Shah, lead author

Pitt told Esquire magazine in 2013 he had such a hard time recognising people he has met that he thought he must have prosopagnosia. At the time he said the situation was worsening so he was thinking of being tested for it. Former Dragons Den star Duncan Bannatyne, Stephen Fry and the Labour politician Patricia Hewitt also reportedly suffer the same affliction.

Researchers at Anglia Ruskin University have now come up with a simple questionnaire that can provide an accurate way of assessing face recognition. In tests, volunteers were asked the extent to which they agreed or disagreed with 20 statements such as I often mistake people I have met before for strangers or I sometimes find movies hard to follow because of difficulties recognising characters.

Comparing the scores with results from in depth computerised face recognition tasks demonstrated that the test could quickly and effectively diagnose the condition.

Psychologist Dr Punit Shah said: Some people with face blindness struggle to recognise their family and friends, and this can have a negative impact on their lives. Face blindness has been recognised by the NHS since 2016 and it is important to establish how many people are affected in order that they receive the assistance they need.

Psychologists interested in face blindness have been hesitant to use questionnaires, but our new study suggests that using a well-designed questionnaire is helpful in recognising the condition and is suitable to be used on a large scale.

We are now adapting this questionnaire as there is evidence that prosopagnosia exists in children. It could help to explain why some children struggle to make close friends, and the problem could be more acute in schools where uniforms are worn.

Therapeutic training programmes known to work in adults could be even more successful in children because of their plastic brains, he said.

Dr Shah added: There is still a lot to learn about prosopagnosia, but this research into identifying the condition using questionnaires is hopefully a step in the right direction.

The findings are published in The Quarterly Journal of Experimental Psychology.

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Livonia man refused to let blindness keep him from skateboarding – WXYZ

Thursday, May 18th, 2017

LIVONIA, Mich. (WXYZ) - If you are lucky enough to see Daniel Mancina out skateboarding, you notice right away he has a cane. It takes a moment to comprehend why, because it seems almost impossible.

The cane looks cool, cuz everyone is like- oh wow that guy is blind, said Daniel.

Daniel has RP or Retinitis pigmentosa. It slowly has taken away his ability to see.

I found out when I was 13. I went to a normal eye check up and the optometrist noticed something that wasnt right, said Daniel By his early twenties the Livonia man lost much of his vision.

I definitely went through a couple years of depression and feeling really bad about myself, said Daniel. He said at some point he decided he wasnt going to give in to self-pity.

You are only as disabled as your attitude is.

He decided to try to get back on the board about four years ago. He wasnt sure if he could do it. He is 100% blind in the left eye, and 95% blind in the other. The small peripheral vision he has in his right eye is blurry. The 29-year-old found he could skateboard using the lines he can barely see painted on a tennis court .

I cant see the board or the box. All I see are the white lines., said Daniel.

Still he attempts moves fromthe crooked grind to flip tricks.

It is a really crazy feeling. It is all feel and trustthat the board is going to be there.

Like any skateboarder, Daniel wipes out. His message is about getting back up.

It is just like in life. You know you need to keep getting up and dusting yourself off, no matter the obstacle in life, he said.

Daniel is using social media to spread his story and inspire others. You can follow him at https://www.instagram.com/blindphoto/.

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New eye drops to treat age-related blindness developed – The Hindu

Wednesday, May 17th, 2017

Daily Mail
New eye drops to treat age-related blindness developed
The Hindu
Scientists have developed a revolutionary new eye drop to treat an age-related eye disorder, spelling the end for painful injections used to combat one of the leading causes of blindness. The eye disorder known as age-related macular degeneration (AMD ...
Eye drops for blindness could stop need for injectionsDaily Mail
Scientists develop eye drops to cure age-related blindnessNews Nation
Soon, Eye Drops to Replace Painful Injections in Vision-Loss TreatmentNDTV
ReliaWire
all 9 news articles »

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Scientists have developed a potential cure for blindness and it only takes a single injection – The Sun

Wednesday, May 17th, 2017

Eye docs believethe treatment could help over 60,000 Brits who suffer from wet age-related macular degeneration

EXPERTS have developed a potential cure for one of the UKs leading causes of sight loss.

The therapy safely and effectively treated wet age-related macular degeneration (AMD) in trials.

Getty Images

Wet AMD which affects 60,000 Brits is a painless condition that causes loss of central vision.

It develops when abnormal blood vessels leak fluid into the macula, found at the back of the eye.

This makes things look blurry and reading, driving and recognising faces becomes difficult.

Getty Images

Patients currently require monthly injections into the eye that help to temporarily clear up the fluid.

But many find the process cumbersome, so give up, and eventually lose their sight.

Now scientists believe they have found a way of curing the condition with just one jab.

Getty Images

Abnormal blood vessels form because patients produce too much of the growth factor VEGF.

Current injections contain a protein that binds to VEGF and inactivates it.

But this leaks from the eye over the course of a month and needs to be topped-up.

The new jab contains a modified virus like the common cold that penetrates cells in the eye and deposits a therapeutic gene.

This instructs the cells to produce a constant supply of the anti-VEGF protein, meaning it no longer needs to be injected.

Study leader Peter Campochiaro, a professor at Johns Hopkins University, in Maryland, US, said: This preliminary study is a small but promising step towards a new approach.

It will not only reduce doctor visits and the anxiety and discomfort associated with repeated injections in the eye, but may improve long-term outcomes.

Prolonged suppression of VEGF is needed to preserve vision, and that is difficult to achieve with repeated injections because life often gets in the way.

Even at the highest dose, the treatment was quite safe. We found there were almost no adverse reactions in our patients.

The phase one clinical trial involved 19 men and women, aged 50 years or older.

For safety and ethical reasons, the study group was composed of people for whom standard approved treatments were highly unlikely to be successful.

It meant that only 11 of the 19 had the potential for fluid reduction.

Of those eleven patients, four showed dramatic improvements, with the amount of fluid in their eyes dropping from severe to almost nothing.

Two other participants showed a partial reduction in the amount of fluid in their eyes and five showed no reduction in fluid levels.

All of the patients who failed to improve were found to be immune to the virus, meaning their body probably destroyed it before it had a chance to insert the gene.

Researchers warn this is likely to limit the therapys use because 60 per cent of the population is believed to be immune. They are continuing to investigate its constraints.

The findings are published in the Lancet medical journal.

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Scientists have developed a potential cure for blindness and it only takes a single injection - The Sun

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457 visa crackdown derails drug to cure blindness – The Australian Financial Review

Wednesday, May 17th, 2017

Things looked great for Xianzhong Lau a month ago. The 30-year-old Singaporean had completed a PhD in translational biology and snared a job as a project leader with a company founded by one of Australia's top life sciences entrepreneurs, Darren Kelly.

All he needed was the 457 visa that he had already applied for to come through, and he could look forward to some exciting work with Melbourne-based OccuRx as it worked on plans to bring a drug aimed at curing retinal blindness to clinical trials next year.

Days later Lau's plans lay in ruins after Prime Minister Malcolm Turnbull's shock "Australia first" decision to abolish 457 visas. With his existing 485 visa which lets post-graduates stay 18 months due to expire Lau had to quit his job at OccuRx and return to Singapore within two weeks.

He told the Singapore Straits Times it was "devastating" to have to uproot his life in Melbourne, where he had lived for nine years, in a fortnight. Now he is trying to be positive, Australia's loss could be another country's gain.

"I'll be looking locally [for a new job] and probably elsewhere in Europe and Canada or somewhere like that, just to keep my options open," Lau tells The Australian Financial Review from his home in Singapore.

"The global climate right now is protectionist, so everyone understands that Australia wants to protect local jobs."

If he lands a job in Singapore, he will pay less tax rate than in Australia, where the top rate cutting in at $180,000 could rise to 49.5 per cent if Labor has its way. Singaporeans pay no more than 18 per cent on income up to $S200,000 ($192,000).

For Darren Kelly, it means spending three to six months finding another project leader who can match Lau's rare combination of entrepreneurial and life sciences skills, just as OccuRx should be pedal to metal on its research and raising more capital next year for clinical trials.

"This will leave us seriously short staffed in the middle of a key project," Kelly says.

"To make such a major change with no industry consultation is short-sighted and is damaging to the National Innovation & Science Agenda.

"It's frustrating because we run biotech companies quite lean financially and human resources are a critical part of keeping our program moving." It's also vital to keep research moving as a company moves closer to clinical trials of a new drug.

Kelly is one of the Aussie life sciences industry's pin-up boys after selling Fibrotech, the drug developer he spun out of Melbourne University, to Irish drug group Shire Pharmaceuticals for up to $500 million in 2014. OccuRx has raised $10 million to find a cure for retinal disease, a common cause of blindness, and Melbourne has made him associate dean of innovation and commercialisation.

Not even those credentials could insulate him from the sudden policy reversal. Lau's combination of skills is so rare in Australia that the Turnbull government made it the focus of innovation policy and seeded a $500 million Biomedical Translation Fund, only to get cold feet after voters decided that innovation was more threatening than exciting.

"We have a skills shortage of people with a science and business background and the 457 visa allows us to bridge that gap," Kelly says.

"Until we educate our local workforce, we need to have the ability to bring in skills from overseas."

OccuRx has one other affected worker apart from Lau. The company is just one example among many of the 457 visa changes causing chaos at life sciences companies and university research teams.

Blood products giant CSL said last week it had about 40 staff on 457 visas, including top managers at its manufacturing plant in Broadmeadows who are transferring skills and knowhow from a model plant in Switzerland, but was confident it would get some relief when immigration officials produce a revised list by July 1. Tech firms such as Atlassian and universities have also complained the new rules will make life harder for them.

Even the heads of federal agencies such as NBN chief executive Bill Morrow and Australian Energy Market Operator Audrey Zibelman are potentially snared by the sweeping changes.

Immigration Minister Peter Dutton has agreed to review the list in response to complaints but lives are being turned upside down in the meantime.

Lau faces a challenge matching his unusual skill set to a job opening. "Even though all of us are researchers we are very diverse in the skill sets that we have. From the background of our studies we each find our own niche, so it's a tricky issue."

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Grandmother ‘scammed’ $200K from taxpayers by faking blindness – Starts at 60

Wednesday, May 17th, 2017

A Sydney grandmother has been accused of scamming taxpayers of more than $200,000 by pretending to be blind for 21 years.

Channel 9s A Current Affair reported last night that Rebecca Assie hadreceiveda disability pension for the past 21 years after claiming that she was unable to work due to blindness, despite also passing the sight tests required to obtain a drivers licence.

ACA, which videoed Assie walking about her neighbourhoodand going about activities without assistance or apparent vision impairment, said thatthe 60-year-old shopped around for an ophthalmologist that was willing to attest to her blindness, after one told the Department of Human Services that he could not understand why the patient is applying for a pension.

She has normal corrected vision for distance and near, the sceptical ophthalmologist wrote. After Assie found an ophthalmologist willing to certify that she was blind, Centrelink granted her a disability pension.

She also, however, maintained an drivers licence, apparently passing the vision tests required to do so, ACA reported.

But it appeared from the program (below)the DHS had caught up with Assie. ACA also interviewedHuman Services Minister Alan Tudge, who called her case one of the most extraordinary hed come across.

ACA reported that the DHS was now working with the Sydney woman to retrieve the $209,000 in payments she had wrongfully claimed.

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Grandmother 'scammed' $200K from taxpayers by faking blindness - Starts at 60

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Photoreceptor cell death leads to blindness in CLN5 form of Neuronal Ceroid Lipofuscinosis – Medical Xpress

Wednesday, May 17th, 2017

May 16, 2017

Researchers from the University of Eastern Finland have discovered a likely cause for visual impairment and eventual loss of vision in the Finnish variant of Neuronal Ceroid Lipofuscinosis (NCL). Visual impairment associated with the Finnish variant of NCL may be caused by impaired retinal waste management system, including autophagy, leading primarily to the death of photoreceptor cells that are of essential for vision.

The NCLs are the most common neurodegenerative disease group among children. NCL diseases constitute part of the Finnish disease heritage and they are more common in Finland than anywhere else in the world. Childhood NCL diseases lead to loss of vision and to premature death. No drug therapy to stop the disease is approved by the drug regulatory agencies, and the disease mechanisms remain poorly understood.

A new study carried out at the University of Eastern Finland analysed the causes behind loss of vision and detrimental retinal changes in CLN5 disease, i.e. the Finnish variant of NCL. The researchers used genetically modified mice in which the gene encoding the CLN5 protein had been made defective. In humans, malfunction of the gene leads to CLN5 disease.

The researchers found that CLN5 deficient mice developed retinal degeneration long before reaching sexual maturity. Retinal function, especially associated with rod photoreceptors and the retinal pigmented epithelium cells, was reduced in young mice, and a similar phenomenon has been observed in several dog and sheep breeds with NCL. Scientific evidence on humans is inconclusive, but researchers believe that photoreceptor degeneration precedes the degeneration of other parts of the retina in humans as well.

Retinal protein analyses revealed that compared to age-matched controls, CLN5 deficient mice had abnormal levels of several autophagy related proteins in the retina. Earlier studies have observed similar changes and impaired lysosomal degradation in several distinct tissues from mice expressing other forms of NCL, including brain tissue. Lysosomal degradation is the final phase of autophagy, preventing the accumulation of detrimental waste materials in cells.

Normal visual function requires constant renewal of photoreceptors through lysosomal degradation. In CLN5 deficient mice, this degradation mechanism seems impaired, and this is why photoreceptors may die as the disease progresses, although detrimental pigment accumulation typical of NCL diseases can be observed in the entire retina. Similar retinal changes have also been observed in mice, dogs and sheep with several other forms of NCL, suggesting that the findings could apply to several forms of NCL. According to the researchers, the role of impaired lysosomal degradation in NCL-associated detrimental changes in the brain remains unknown.

"Non-invasive retinal examinations could possibly be used as biomarkers of central nervous system diseases", says Henri Leinonen, Ph.D., the first author of the article. In the future, retinal examinations may prove useful in studying treatment responses and disease progression in neurological diseases. Compared to brain examinations, retinal examinations have the advantage of being relatively cost-effective and safe. In NCL diseases, retinal examinations are used to study disease mechanisms in animals, and nowadays retinal examinations can also be used to support diagnosis in humans.

Explore further: Brain diseases manifest in the retina of the eye

More information: Henri Leinonen et al, Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy, Scientific Reports (2017). DOI: 10.1038/s41598-017-01716-1

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In a small and preliminary clinical trial, Johns Hopkins researchers and their collaborators have shown that an experimental gene therapy that uses viruses to introduce a therapeutic gene into the eye is safe and that it ...

Monthly eye injections of Avastin (bevacizumab) are as effective as the more expensive drug Eylea (aflibercept) for the treatment of central retinal vein occlusion (CRVO), according to a clinical trial funded by the National ...

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Do you suffer from inattentional blindness on the road? – KMSP-TV

Wednesday, May 17th, 2017

(KMSP) - Drivers can be blinded by distraction even when their eyes are on the road.

The Fox 9 Investigators saw how this happens after testing six drivers at the Dakota County Technical College and asking them to drive on the closed driving track while they talked on their phones, which is legal to do in Minnesota.

Professor Dan Simons is an awareness researcher from the University of Illinois.

"You can look right at something, stare directly at it and simply not see it because your mind is otherwise occupied," he said.

Researchers have a name for the strange trick our brains can play and its called inattentional blindness."

In 2015, 74 deaths and 5,387 injuries were linked to inattentive driving in Minnesota.

Last year, state insurance premiums had their biggest increase in nearly a decade.

The average 2017 car insurance premium is now $772.

"You can't hold a good conversation when you're driving, and you can't drive effectively while you're holding a conversation. Those two things are mutually interfering with each other," said Simons.

DISTRACTED DRIVERS ON THE COURSE

The volunteer drivers were asked to drive the course and count the number of cones covered with white bags.

At the same time, they were talking with Aaron Machtemes by phone.

At the time, they didnt know he is a police officer from Eagan and was watching them from a squad car on a hill overlooking the track.

We placed some eye-catching items right next to the cones, including a tire, a toy car, a school bus with its stop arm extended, a Santa Claus decoration and a second stroller.

Trying to count cones while talking to the officer was challenging for all the drivers.

"You're more likely to be using up those attention resources, which makes you less likely to notice something unexpected," said Simons.

At the end of each run, Machtemes pulled right behind the test car with his emergency lights on.

Four drivers saw the squad and pulled over.

But two were so engaged in conversation with him, they didnt notice he was following them, so he was forced to put on his siren to get their visual attention.

THERE WAS A SCHOOL BUS ON THE TRACK

One of the drivers didnt even remember passing by the school bus with its stop arm extended.

A second driver said he saw the bus, but not the stop arm or the flashing red lights.

Every one of the volunteers could not recall seeing some of the items that were right next to the cones they were counting.

The point is: a persons attention has limits, especially while driving.

"What we don't realize is having that conversation is really cognitively demanding as is driving. And they interfere with each other. It's a lot like we know we can't whistle and chew gum at the same time," said Simons.

He added that using a hands-free device doesn't make a difference.

Just talking uses up attention resources, which means drivers are less likely to notice something unexpected.

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Pretty Miss Barda cries for help to prevent total blindness – Vanguard

Tuesday, May 16th, 2017

Requires N3m lifeline for eye surgery in Kaduna Swindlers hit peasant family

By Cletus Opukeme

KIAGBODO FOR fine-looking 27-year-old Miss Blessing Barda, an indigene of Kiagbodo, Burutu Local Government Area, Delta State, who is slowly going blind due to ulcer infection in her eyes, what is standing between her life and death is the sum of N3 million. She requires it urgently to undergo operation at a specialist institution, Relish Eye Hospital, Kaduna, operated by Indians, but neither she nor her peasant family, has the money.

Her appeal to the governor of Delta State, Senator Ifeanyi Okowa, Burutu local government council and kind-hearted Nigerians is to raise the funds to enable her undergo an operation at the hospital to save her from completely going blind. Miss Brada, who spoke to NDV, said she had earlier undergone a cornea transplant operation sponsored by the Niger Delta Development Commission, NDDC, following the intervention of a prominent Deltan, but obviously the problem is still there.

Heartless fraudsters dupe family: With tears dripping from her eyes, she told NDV that her problem started in 2005, but despite her challenges, some unscrupulous people have taken advantage of the situation to extort money from the family amongst other vulgarities. Dejected Barda said she had visited several eye hospitals, tests, recommendations and treatment were carried out, but lack of money for proper follow-up made her case to deteriorate, hence her cry to the state government, Burutu local government council and nongovernmental organizations to help to avert complete blindness blind.

Lack of funds: These issues aggravated because there was no money to go to a better hospital with better facilities to get good treatment. Since then, I have been going to Benin once every month for treatment and drugs.

She concluded: The female optician there referred me to a specialist hospital in Kaduna called Relish Eye Hospital; this hospital is managed by Indians. I went to Kaduna and a test was carried out to ascertain the level of damage to know if the right eye can still be operated upon so that my sight can be restored. The result shows that there is 90 per cent chance of complete restoration of my sight but treatment will cost N2 million, please come to my aid to give me back my sight, she pleaded.

While expressing appreciation to all in anticipation of positive and quick response by the state government, Burutu local government and public spirited individuals, Miss Barda gave details of how she could be reached with donations through her mother. Account Name: Jane Barda, Account Number: 3084575262, First Bank and phone number: 07035383650

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