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Five innovations harness new technologies for people with visual impairment, blindness – Science Daily

Monday, February 6th, 2017

During Low Vision Awareness Month, the National Eye Institute (NEI), part of the National Institutes of Health, is highlighting new technologies and tools in the works to help the 4.1 million Americans living with low vision or blindness. The innovations aim to help people with vision loss more easily accomplish daily tasks, from navigating office buildings to crossing a street. Many of the innovations take advantage of computer vision, a technology that enables computers to recognize and interpret the complex assortment of images, objects and behaviors in the surrounding environment.

Low vision means that even with glasses, contact lenses, medicine, or surgery, people find everyday tasks difficult to do. It can affect many aspects of life, from walking in crowded places to reading or preparing a meal, explained Cheri Wiggs, Ph.D., program director for low vision and blindness rehabilitation at the NEI. The tools needed to stay engaged in everyday activities vary based on the degree and type of vision loss. For example, glaucoma causes loss of peripheral vision, which can make walking or driving difficult. By contrast, age-related macular degeneration affects central vision, creating difficulty with tasks such as reading, she said.

Here's a look at a few NEI-funded technologies under development that aim to lessen the impact of low vision and blindness.

Co-robotic cane

Navigating indoors can be especially challenging for people with low vision or blindness. While existing GPS-based assistive devices can guide someone to a general location such as a building, GPS isn't much help in finding specific rooms, said Cang Ye, Ph.D., of the University of Arkansas at Little Rock. Ye has developed a co-robotic cane that provides feedback on a user's surrounding environment.

Ye's prototype cane has a computerized 3-D camera to "see" on behalf of the user. It also has a motorized roller tip that can propel the cane toward a desired location, allowing the user to follow the cane's direction. Along the way, the user can speak into a microphone and a speech recognition system interprets verbal commands and guides the user via a wireless earpiece. The cane's credit card-sized computer stores pre-loaded floor plans. However, Ye envisions being able to download floor plans via Wi-Fi upon entering a building. The computer analyzes 3-D information in real time and alerts the user of hallways and stairs. The cane gauges a person's location in the building by measuring the camera's movement using a computer vision method. That method extracts details from a current image captured by the camera and matches them with those from the previous image, thus determining the user's location by comparing the progressively changing views, all relative to a starting point. In addition to receiving NEI support, Ye recently was awarded a grant from the NIH's Coulter College Commercializing Innovation Program to explore commercialization of the robotic cane.

Robotic glove finds door handles, small objects

In the process of developing the co-robotic cane, Ye realized that closed doorways pose yet another challenge for people with low vision and blindness. "Finding the door knob or handle and getting the door open slows you way down," he said. To help someone with low vision locate and grasp small objects more quickly, he designed a fingerless glove device.

On the back surface is a camera and a speech recognition system, enabling the user to give the glove voice commands such as "door handle," "mug," "bowl," or "bottle of water." The glove guides the user's hand via tactile prompts to the desired object. "Guiding the person's hand left or right is easy," Ye said. "An actuator on the thumb's surface takes care of that in a very intuitive and natural way." Prompting a user to move his or her hand forward and backward, and getting a feel for how to grasp an object, is more challenging.

Ye's colleague Yantao Shen, Ph.D., University of Nevada, Reno, developed a novel hybrid tactile system that comprises an array of cylindrical pins that send either a mechanical or electrical stimulus. The electric stimulus provides an electrotactile sensation, meaning that it excites the nerves on the skin of the hand to simulate a sense of touch. Picture four cylindrical pins in alignment down the length of your index finger. One by one, starting with the pin closest to your finger tip, the pins pulse in a pattern indicating that the hand should move backward.

The reverse pattern indicates the need for forward motion. Meanwhile, a larger electrotactile system on the palm uses a series of cylindrical pins to create a 3-D representation of the object's shape. For example, if your hand is approaching the handle of a mug, you would sense the handle's shape in your palm so that you could adjust the position of your hand accordingly. As your hand moves toward the mug handle, any slight shifts in angle are noted by the camera and the tactile sensation on your palm reflects such changes.

Smartphone crosswalk app

Street crossings can be especially dangerous for people with low vision. James Coughlan, Ph.D., and his colleagues at the Smith-Kettlewell Eye Research Institute have developed a smartphone app that gives auditory prompts to help users identify the safest crossing location and stay within the crosswalk.

The app harnesses three technologies and triangulates them. A global positioning system (GPS) is used to pinpoint the intersection where a user is standing. Computer vision is then used to scan the area for crosswalks and walk lights. That information is integrated with a geographic information system (GIS) database containing a crowdsourced, detailed inventory about an intersection's quirks, such as the presence of road construction or uneven pavement. The three technologies compensate for each other's weaknesses. For example, while computer vision may lack the depth perception needed to detect a median in the center of the road, such local knowledge would be included in the GIS template. And while GPS can adequately localize the user to an intersection, it cannot identify on which corner a user is standing. Computer vision determines the corner, as well as where the user is in relation to the crosswalk, the status of the walk lights and traffic lights, and the presence of vehicles.

CamIO system helps explore objects in a natural way

Imagine a system that enables visually impaired biology students to explore a 3-D anatomical model of a heart by touching an area and hearing "aortic arch" in response. The same system could also be used to get an auditory readout of the display on a device such as a glucose monitor. The prototype system, designed with a low-cost camera connected to a laptop computer, can make physical objects -- from 2-D maps to digital displays on microwaves -- fully accessible to users with low vision or blindness.

The CamIO (short for camera input-output), also under development by Coughlan, provides real-time audio feedback as the user explores an object in a natural way, turning it around and touching it. Holding a finger stationary on 3-D or 2-D objects, signals the system to provide an audible label of the location in question or an enhanced image on a laptop screen. CamIO was conceived by Joshua Miele, Ph.D, a blind scientist at Smith-Kettlewell who develops and evaluates novel sound/touch interfaces to help people with vision loss. Coughlan plans to develop a smartphone app version of CamIO. In the meantime, software for the laptop version will be available for free download. To watch a demonstration of the CamIO system, visit http://bit.ly/2CamIO.

High-powered prisms, periscopes for severe tunnel vision

People with retinitis pigmentosa and glaucoma can lose most of their peripheral vision, making it challenging to walk in crowded places like airports or malls. People with severe peripheral field vision loss can have a residual central island of vision that's as little as 1 to 2 percent of their full visual field. Eli Peli, O.D., of Schepens Eye Research Institute, Boston, has developed lenses constructed of many adjacent one-millimeter wide prisms that expand the visual field while preserving central vision. Peli designed a high-powered prism, called a multiplexing prism that expands one's field of view by about 30 degrees. "That's an improvement, but it's not good enough," explained Peli.

In a study, he and his colleagues mathematically modeled people walking in crowded places and found that the risk of collision is highest when other pedestrians are approaching from a 45-degree angle. To reach that degree of peripheral vision, he and his colleagues are employing a periscope-like concept. Periscopes, such as those used to see the ocean surface from a submarine, rely on a pair of parallel mirrors that shift an image, providing a view that would otherwise be out of sight. Applying a similar concept, but with non-parallel mirrors, Peli and colleagues have developed a prototype that achieves a 45-degree visual field. Their next step is to work with optical labs to manufacture a cosmetically acceptable prototype that can be mounted into a pair of glasses. "It would be ideal if we could design magnetic clip-ons spectacles that could be easily mounted and removed," he said.

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Blindness (film) – Wikipedia

Monday, February 6th, 2017

Blindness is a 2008 Brazilian-Canadian film, an adaptation of the 1995 novel of the same name by Portuguese author Jos Saramago about a society suffering an epidemic of blindness. The film was written by Don McKellar and directed by Fernando Meirelles with Julianne Moore and Mark Ruffalo as the main characters. Saramago originally refused to sell the rights for a film adaptation, but the producers were able to acquire it with the condition that the film would be set in an unnamed and unrecognizable city. Blindness premiered as the opening film at the Cannes Film Festival on May 14, 2008, and the film was released in the United States on October 3, 2008.

A young Japanese professional is struck blind in his car at a crossing and is then approached by a few people, one offers to drive him home and steals his car. The blinded man describes his sudden affliction: an expanse of dazzling white. Upon arriving home and noticing her husband's blindness, the man's wife takes him to a local ophthalmologist who, after testing the man's eyes, can identify nothing wrong and recommends further evaluation at a hospital. Among the doctor's patients are an old man with a black eye-patch, a woman with dark glasses and a young boy. During a dinner with his wife, the doctor discusses the strange case. The woman with dark glasses, revealed to be a call-girl, becomes the third victim of the strange blindness after an appointment with a john in a hotel.

The next day, the doctor goes blind as well. Around the city, more citizens are struck blind, causing widespread panic, and the government organizes a quarantine for the blind in a derelict asylum. When a hazmat crew arrives to pick up the doctor, his wife climbs into the van, lying that she has gone blind in order to accompany him.

In the asylum, the doctor and his wife are first to arrive and both agree they will keep her sight a secret. Several others arrive: the woman with dark glasses, the Japanese man, the car thief, and the young boy. The wife comes across the old man with the eye-patch, who describes the condition of the world outside. The sudden blindness, known as the "white sickness", is now international, with hundreds of cases reported every day. The increasingly totalitarian government resorts to increasingly ruthless measures to try to staunch the epidemic, refusing the sick aid or medicines.

As more blind people are crammed into the prison, overcrowding and lack of outside support causes hygiene and living conditions to degrade. Soon, the walls and floors are caked in filth and human feces. Anxiety over the availability of food undermines the morale and the lack of organization prevents the fair distribution of food. The soldiers who guard the asylum become hostile.

Living conditions degenerate further when an armed clique of men, led by an ex-barman who declares himself the king of ward 3 gains control over the food deliveries. The MRE rations are distributed only in exchange for valuables, and then for the women of the other wards. Faced with starvation, the doctor's wife kills the king. His death initiates a chaotic war between the wards, which culminates with the asylum being burned down and many inmates dying in the fire. The survivors discover that the guards have abandoned their posts and they are free to venture into the city.

Society has fallen as the entire population is blind amid a city devastated and overrun with filth and dead bodies. The doctor's wife leads her husband and others in search of food and shelter. The doctor and his wife arrive in a supermarket filled with stumbling blind people and they find food in a basement storeroom. As she prepares to leave and meet her husband outside, she is attacked by the starving people who smell the food she is carrying. Her husband, now used to his blindness, saves her and they manage to return to their friends.

The doctor and his wife with their new "family" make their way back to the doctor's house, where they establish a permanent home. Just as suddenly as his sight had been lost, the Japanese man recovers his sight. As the friends all celebrate, the doctor's wife stands out on the porch, staring up into a white overcast sky and appears to be going blind until the camera shifts downwards, revealing that she sees the cityscape.

Secondary characters include:

Meirelles chose an international cast. Producer Niv Fichman explained Meirelles' intent: "He was inspired by [Saramago's] great masterwork to create a microcosm of the world. He wanted it cast in a way to represent all of humanity."[10]

The rights to the 1995 novel Blindness were closely guarded by author Jos Saramago.[6] Saramago explained, "I always resisted because it's a violent book about social degradation, rape, and I didn't want it to fall into the wrong hands." Director Fernando Meirelles had wanted to direct a film adaptation in 1997, perceiving it as "an allegory about the fragility of civilization". Saramago originally refused to sell the rights to Meirelles, Whoopi Goldberg, or Gael Garca Bernal.[11] In 1999, producer Niv Fichman and Canadian screenwriter Don McKellar visited Saramago in the Canary Islands; Saramago allowed their visit on condition that they not discuss buying the rights. McKellar explained the changes he intended to make from the novel and what the focus would be, and two days later he and Fichman left Saramago's home with the rights. McKellar believed they had succeeded where others had failed because they properly researched Saramago; he was suspicious of the film industry and had therefore resisted other studios' efforts to obtain the rights through large sums of money alone.[12] Conditions set by Saramago were for the film to be set in a country that would not be recognizable to audiences,[13] and that the canine in the novel, the Dog of Tears, should be a big dog.[14]

Meirelles originally envisioned doing the film in Portuguese similar to the novel's original language, but instead directed the film in English, saying, "If you do it in English you can sell it to the whole world and have a bigger audience."[9] Meirelles set the film in a contemporary large city, seemingly under a totalitarian government, as opposed to the novel that he believed took place in the 1940s (actually, the book is more likely to take place in the 80s or later, as evident by the fact that the characters stumble upon a store with modern appliances like microwave ovens and dishwashers, and referral to AIDS as a feared disease). Meirelles chose to make a contemporary film so audiences could relate to the characters.[14] The director also sought a different allegorical approach. He described the novel as "very allegorical, like a fantasy outside of space, outside the world", and he instead took a naturalistic direction in engaging audiences to make the film less "cold."[15]

Don McKellar said about adapting the story, "None of the characters even have names or a history, which is very untraditional for a Hollywood story. The film, like the novel, directly addresses sight and point of view and asks you to see things from a different perspective." McKellar wrote the script so audiences would see the world through the eyes of the protagonist, the doctor's wife. He sought to have them question the humanity of how she observes but does not act in various situations, including a rape scene. He consulted Saramago about why the wife took so long to act. McKellar noted, "He said she became aware of the responsibility that comes with seeing gradually, first to herself, then to her husband, then to her small family, then her ward, and finally to the world where she has to create a new civilization." The screenwriter wrote out the "actions and circumstances" that would allow the wife to find her responsibility.[5] While the completed script was mostly faithful to the novel, McKellar went through several drafts that were not. One such saw him veer away from the novel by creating names and backstories for all the characters. Another significantly changed the chronology. Only after these abortive attempts did McKellar decide to cut the backstories and focus primarily on the doctor and his wife. He attempted to reconnect with what originally drew him to the novel: what he called its "existential simplicity". The novel defines its characters by little more than their present actions; doing the same for the adaptation became "an interesting exercise" for McKellar.[12]

McKellar attended a summer camp for the blind as part of his research. He wanted to observe how blind people interacted in groups. He discovered that excessive expositional dialogue, usually frowned upon by writers, was essential for the groups. McKellar cut one of the last lines in the novel from his screenplay: "I don't think we did go blind, I think we are blind. Blind but seeing. Blind people who can see, but do not see." McKellar believed viewers would by that point have already grasped the symbolism and didn't want the script to seem heavy-handed. He also toned down the visual cues in his screenplay, such as the "brilliant milky whiteness" of blindness described in the novel. McKellar knew he wanted a stylistically adept director and didn't want to be too prescriptive, preferring only to hint at an approach.[12]

Meirelles chose So Paulo as the primary backdrop for Blindness, though scenes were also filmed in Osasco, Brazil; Guelph, Ontario, Canada; and Montevideo, Uruguay. With all the characters aside from Julianne Moore's character being blind, the cast was trained to simulate blindness. The director also stylized the film to reflect the lack of point of view that the characters would experience. Meirelles said several actors he talked to were intimidated by the concept of playing characters without names: "I offered the film to some actors who said, 'I can't play a character with no name, with no history, with no past. With Gael (Garca Bernal), he said, 'I never think about the past. I just think what my character wants.'"[16]

By September 2006, Fernando Meirelles was attached to Blindness, with the script being adapted by Don McKellar. Blindness, budgeted at $25 million as part of a Brazilian and Canadian co-production, was slated to begin filming in summer 2007 in the towns of So Paulo and Guelph.[17] Filming began in early July in So Paulo and Guelph.[18] Filming also took place in Montevideo, Uruguay.[19] So Paulo served as the primary backdrop for Blindness, being a city mostly unfamiliar to U.S. and European audiences. With its relative obscurity, the director sought So Paulo as the film's generic location. Filming continued through autumn of 2007.[6]

The cast and crew included 700 extras who had to be trained to simulate blindness. Actor Christian Duurvoort from Meirelles' City of God led a series of workshops to coach the cast members. Duurvoort had researched the mannerisms of blind people to understand how they perceive the world and how they make their way through space. Duurvoort not only taught the extras mannerisms, but also to convey the emotional and psychological states of blind people.[6] One technique was reacting to others as a blind person, whose reactions are usually different from those of a sighted person. Meirelles described, "When you're talking to someone, you see a reaction. When you're blind, the response is much flatter. What's the point [in reacting]?"[20]

Meirelles acknowledged the challenge of making a film that would simulate the experience of blindness to the audience. He explained, "When you do a film, everything is related to point of view, to vision. When you have two characters in a dialogue, emotion is expressed by the way people look at each other, through the eyes. Especially in the cut, the edit. You usually cut when someone looks over. Film is all about point of view, and in this film there is none."[20] Similar to the book, blindness in the film serves as a metaphor for human nature's dark side: "prejudice, selfishness, violence and willful indifference."[6]

With only one character's point of view available, Meirelles sought to switch the points-of-view throughout the film, seeing three distinct stylistic sections. The director began with an omniscient vantage point, transited to the intact viewpoint of the doctor's wife, and changed again to the Man with the Black Eye Patch, who connects the quarantined to the outside world with stories. The director concluded the switching with the combination of the perspective of the Doctor's Wife and the narrative of the Man with the Black Eye Patch.[5]

The film also contains visual cues, such as the 1568 painting The Parable of the Blind by Pieter Bruegel the Elder. Allusions to other famous artworks are also made. Meirelles described the intent: "It's about image, the film, and vision, so I thought it makes sense to create, not a history of painting, because it's not, but having different ways of seeing things, from Rembrandt to these very contemporary artists. But it's a very subtle thing."[6]

Prior to public release, Meirelles screened Blindness to test audiences. He described the impact of test screenings: "If you know how to use it, how to ask the right questions, it can be really useful." A test screening of Meirelles' first cut in Toronto resulted in ten percent of the audience, nearly 50 people, walking out of the film early. Meirelles ascribed the problem to a rape scene that takes place partway through the film, and edited the scene to be much shorter in the final cut.[21] Meirelles explained his goal, "When I shot and edited these scenes, I did it in a very technical way, I worried about how to light it and so on, and I lost the sense of their brutality. Some women were really angry with the film, and I thought, 'Wow, maybe I crossed the line.' I went back not to please the audience but so they would stay involved until the end of the story."[9] He also found that a New York City test screening expressed concern about a victim in the film failing to take revenge. Meirelles believed this concern to reflect what Americans have learned to expect in their cinema.[21]

Focus Features acquired the right to handle international sales for Blindness.[22]Path acquired UK and French rights to distribute the film,[23] and Miramax Films won U.S. distribution rights with its $5 million bid.[24]Blindness premiered as the opening film at the 61st Cannes Film Festival on May 14, 2008,[25] where it received a "tepid reception."[26] Straw polls of critics were "unkind" to the film.[27]

Blindness was screened at the Toronto International Film Festival in September 2008 as a Special Presentation.[28] The film also opened at the Atlantic Film Festival on September 11, 2008,[29] and had its North American theatrical release on October 3, 2008.

The film was on some critics' top ten lists of 2008 films but has received very mixed, predominantly negative reviews. With only 66 of 153 (43%) reviews on the film review site Rotten Tomatoes being positive Blindness is considered "rotten". The film has an average rating of 5.2 out of 10.[30]

Screen International's Cannes screen jury which annually polls a panel of international film critics gave the film a 1.3 average out of 4, placing the film on the lower-tier of all the films screened at competition in 2008.[31] Of the film critics from the Screen International Cannes critics jury, Alberto Crespi of the Italian publication L'Unit, Michel Ciment of French film magazine Positif and Dohoon Kim of South Korean film publication Cine21, all gave the film zero points (out of four).[31]

Kirk Honeycutt of The Hollywood Reporter described Blindness as "provocative but predictable cinema", startling but failing to surprise. Honeycutt criticized the film's two viewpoints: Julianne Moore's character, the only one who can see, is slow to act against atrocities, and the behavior of Danny Glover's character comes off as "slightly pompous". Honeycutt explained, "This philosophical coolness is what most undermines the emotional response to Meirelles' film. His fictional calculations are all so precise and a tone of deadly seriousness swamps the grim action."[32] Justin Chang of Variety described the film: "Blindness emerges onscreen both overdressed and undermotivated, scrupulously hitting the novel's beats yet barely approximating, so to speak, its vision." Chang thought that Julianne Moore gave a strong performance but did not feel that the film captured the impact of Saramago's novel.[33]Roger Ebert called Blindness "one of the most unpleasant, not to say unendurable, films I've ever seen."[34]A. O. Scott of The New York Times stated that, although it "is not a great film, ... it is, nonetheless, full of examples of what good filmmaking looks like."[35]

Stephen Garrett of Esquire complimented Meirelles' unconventional style: "Meirelles [honors] the material by using elegant, artful camera compositions, beguiling sound design and deft touches of digital effects to accentuate the authenticity of his cataclysmic landscape." Despite the praise, Garrett wrote that Meirelles' talent at portraying real-life injustice in City of God and The Constant Gardener did not suit him for directing the "heightened reality" of Saramago's social commentary.[36]

Peter Bradshaw of The Guardian called it "an intelligent, tightly constructed, supremely confident adaptation": "Meirelles, along with screenwriter Don McKellar and cinematographer Cesar Charlone, have created an elegant, gripping and visually outstanding film. It responds to the novel's notes of apocalypse and dystopia, and its disclosure of a spiritual desert within the modern city, but also to its persistent qualities of fable, paradox and even whimsy." [37] "Blindness is a drum-tight drama, with superb, hallucinatory, images of urban collapse. It has a real coil of horror at its centre, yet is lightened with gentleness and humour. It reminded me of George A Romero's Night of the Living Dead, and Peter Shaffer's absurdist stage-play Black Comedy. This is bold, masterly, film-making."[38]

The Boston Globe's Wesley Morris raved about the leading actress: "Julianne Moore is a star for these terrible times. She tends to be at her best when the world is at its worst. And things are pretty bad in "Blindness," a perversely enjoyable, occasionally harrowing adaptation of Jos Saramago's 1995 disaster allegory. [...] "Blindness" is a movie whose sense of crisis feels right on time, even if the happy ending feels like a gratuitous emotional bailout. Meirelles ensures that the obviousness of the symbolism (in the global village the blind need guidance!) doesn't negate the story's power, nor the power of Moore's performance. The more dehumanizing things get, the fiercer she becomes."[39]

The film appeared on some critics' top ten lists of the best films of 2008. Bill White of the Seattle Post-Intelligencer named it the 5th best film of 2008,[40] and Marc Savlov of The Austin Chronicle named it the 8th best film of 2008.[40]

The film has been strongly criticized by several organizations representing the blind community. Dr. Marc Maurer, President of the National Federation of the Blind, said: "The National Federation of the Blind condemns and deplores this film, which will do substantial harm to the blind of America and the world."[41] A press release from the American Council of the Blind said "...it is quite obvious why blind people would be outraged over this movie. Blind people do not behave like uncivilized, animalized creatures."[42] The National Federation of the Blind announced plans to picket theaters in at least 21 states, in the largest protest in the organization's 68-year history.[43] Jos Saramago has described his novel as allegorically depicting "a blindness of rationality". He dismissed the protests, stating that "stupidity doesn't choose between the blind and the non-blind."[44]

In a closed section, Jos Saramago watched the movie together with Fernando Meirelles. When the movie ended, Saramago was in tears. He turned to Fernando Meirelles and said: "Fernando, I am so happy to have seen this movie as I was the day I finished the book." [45]

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Arizona woman cured of blindness spreads fame of obscure Lebanese saint – Fox News

Monday, February 6th, 2017

The story of a Latina who regained her sight thanks to what is believed to be a miracle performed by St. Charbel, has awakened interest in the relics of this Lebanese saint being kept at a church in Phoenix, Arizona.

Dafne Gutierrez is convinced she was able to see again after she visited the relics at St. Joseph Maronite Catholic Church a year ago. So many people continue to visit the chapel since that it was decided to create a sanctuary in his honor.

The Lebanese pastor of the church, Fr. Wissam Akiki, told EFE that the construction of the sanctuary has already begun and will be shaped like a half-moon, with a large statue of the saint standing at the center.

Gutierrez, whose blindness was healed on Jan. 18, 2016, insists that what happened to her was truly a miracle.

"The doctors can't explain it. At first they thought I was imagining things because I so longed to see, but when they examined me no damage to the optic nerve was to be found," she said. "They were surprised, because according to their diagnosis, I was never going to see again, not even with a cornea transplant," she said.

Cristofer Pereyra, director of the Hispanic Office of the Phoenix Diocese, said that Bishop Thomas Olmsted himself spoke with the doctors and checked very carefully the womans case.

The bishop went to make sure there was no scientific explanation for the miraculous recovery of Dafne's sight, Pereyra said.

Fr. Akiki said that thousands of people now visit the saint's relics for their miraculous powers.

"Dafne came to confess to me, and I told her to pray and have faith. Then I made the sign of the cross on her forehead and her eyes. And then St. Charbel performed the miracle that would benefit her three children," the priest said.

The relics of St. Charbel, whose real name was Youssef Antoun Makhlouf, visited Phoenix between Jan. 15 and Jan. 17, 2016; they have toured various parishes around the country since October 2015.

In view of the great devotion of the faithful to thissaint, it was decided to leave a fragment of his hand in Phoenix,a city with a large Lebanese community.

Gutierrez, who had lived with the Arnold Chiari malformation since age 13, went blind in both eyes several years ago.

"I remember hearing on the news about a saint who did miracles, but I'd already been to so many churches I wasn't very excited about it. It was my sister-in-law who convinced me," she said.

St. Charbel died at age 70 at a Maronite monastery in Lebanon on Christmas Eve, 1898. His body lies in a tomb and was said to remain undecomposed for the greater part of a century.

The saint, who has a long history of healing the sick and disabled, even after his death, was beatified on Dec. 5, 1965, and canonized on Oct. 9, 1977, by Pope Paul VI, making him the first Lebanese saint.

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Portsmouth Daily Times | Prevent Blindness declares February as … – Portsmouth Daily Times

Monday, February 6th, 2017

Today, more than 2 million Americans ages 50 and over have age-related macular degeneration (AMD), according to the Prevent Blindness report, Future of Vision: Forecasting the Prevalence and Costs of Vision Problems. This includes 88,546 in Ohio alone. And, the increase of the population aged 80 and older will lead to rapid growth in the AMD population over the next 20 years, reaching 3.4 million in 2032 and 4.4 million by 2050.

The Ohio Affiliate of Prevent Blindness has declared February as Age-related Macular Degeneration/Low Vision Awareness Month. AMD is a leading cause of vision loss for Americans age 50 and older. It affects central vision, where sharpest vision occurs. Almost 3 million Americans have low vision, according to the National Eye Institute.

According to the recent National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division (NASEM) consensus study, Making Eye Health a Population Health Imperative: Vision for Tomorrow, increasing age, white race, and female gender are associated with a higher risk of AMD. The report also found that a number of environmental, behavioral, genetic, and other physical conditions have been associated with the risk of AMD, including smoking, obesity and genetics.

There may be no symptoms until the disease progresses or affects both eyes, which is why regular eye exams are important. Vision changes due to AMD may include:

Prevent Blindness offers educational materials at no cost through its dedicated web pages and its toll-free number. Resources include:

Prevent Blindness AMD Learning Center- The AMD Learning Center, found at preventblindness.org/amd, provides a variety of educational tools including AMD risk factors, treatment options, an Adult Vision Risk Assessment tool, fact sheets and more.

Living Well with Low Vision- This growing online resource, lowvision.preventblindness.org, offers information ranging from an extensive list of searchable, local low vision resource directories, to an informative blog with news for people living with age-related eye disease and significant visual impairment, and their caregivers, authored by patient advocate and low vision educator Dan Roberts, M.M.E.

By detecting AMD and treating it early, vision loss can be significantly lessened, said Sherry Williams, President & CEO of Prevent Blindness, Ohio Affiliate. We urge everyone to make an appointment for a dilated eye exam today.

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Government turns a Nelson’s Eye to increasing cases of blindness reported in Telangana – The New Indian Express

Monday, February 6th, 2017

HYDERABAD: Telangana state has 2 per cent rate of prevalence of blindness, reveals the District Level Household and Facility Survey (DLHS-4) data. This is the highest in the country.

The DLHS data clearly indicates that the state government needs to ramp up its infrastructure for controlling the increasing rate of blindness in the state.

In India, blindness is caused mainly due to two reasons: cataract and refractive errors like near and far sightedness. And both of them can be avoided if adequate healthcare is available.

The Central government, as far back as in 1976, had launched the National Programme for Control of Blindness (NPCB) for preventing occurrence of blindness.

However, thanks to the poor financial and infrastructural support from the state and following governments at the Centre, the National Programme for Control of Blindness has not been implemented efficiently and widely in the state of Telangana ever since its formulation.

State of affairs

Telangana has around 150 ophthalmic assistants today, located only in the Cluster Health Centres instead of the Primary Health Centres (PHCs). These ophthalmic assistants play a key role in implementation of the School Eye Screening programme of NPCB.

As part of the SES, the assistants prescribe glasses to students of government school aged between 10 and 14 and diagnosed with refractive error. These glasses are provided for free under the programme.

Statistically speaking, there are around 10 lakh children in the age group of 10-14 studying in government schools in the state. This means, each ophthalmic assistant has to keep track of at least 7,000 children every year. This makes it quite clear why, as per NPCB data, the state government could not achieve the target of providing glasses to 52,930 school children in the years 2014-16. They could provide glasses to around 46,000 school children.

Meanwhile, other states including Gujarat and Madhya Pradesh, for the same period, exceeded their targets providing glasses to over 2.3 lakh and 1.5 lakh children respectively.

Other issues

Lack of adequate infrastructure and expertise at district level to undertake cataract surgeries is another issue.

While Gujarat and MP conducted 16 lakh and 10 lakh cataract surgeries in 2014-16 respectively, only 10 lakh surgeries were conducted in Telangana.

NPCB officials pointed out that there has also been a delay in allotment of money by the Centre and state. The central government recently released around Rs 4 crore to NPCB in the state for the year 2016-17 and the state is yet to release its share.

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Government turns a Nelson's Eye to increasing cases of blindness reported in Telangana - The New Indian Express

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The dangers of AMD; disease can cause blindness if left untreated … – KHON2

Monday, February 6th, 2017

It strikes like a thief in the night.

The disease, if left untreated, can slowly steal your central vision, leaving you blind for the rest of your life.

Age-related macular degeneration (AMD) affects more than 10 million people in the U.S.

This is the most common cause of vision loss that is not correctable by lenses or cataract surgery, and is very common in the 80-plus group. Fifty percent of my patients have that disease, said ophthalmologist Dr. Malcolm Ing. That occurs at the back of the eye, right near the optic nerve, right where my finger is. That is the macular, and that is the area that deteriorates.

Patients may notice blacking or graying out at the central part of their vision while reading.

Patients with dry AMD receive antioxidants as treatment.Those with Wet AMD are at higher risk of going blind and must receive injections directly into the eyes every six weeks.

Its a downhill slide right away if you see hemorrhages in the macular, Ing said. If left untreated, you can go blind within a week.

One way to avoid this is to not smoke.

For instance, if you smoke, you have four times the incidents four times 400 percent increase in macular degeneration, Ing explained.

Controlling your weight also helps.

We found that you have a big opu, like some of the people have in our kupuna group, then you increase your incidents by 200 percent, so twice as likely to have that problem, Ing said.

Belly fat produces inflammatory chemicals that target our eyes and brain. Eating fish can reduce risk of AMD by 40 percent, and so can eating green leafy vegetables.

Eat your spinach, because it has green leafy vegetables, and green leafy vegetables has nutrients that help protect the retina, Ing said.

February is AMD Awareness Month, another reason to see your eye doctor regularly.

Click here for more information about AMD from the National Eye Institute.

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Heracleum mantegazzianum – Wikipedia

Wednesday, November 30th, 2016

Heracleum mantegazzianum, commonly known as giant hogweed,[1][2][3]cartwheel-flower,[1][2][3]giant cow parsnip,[4][5]hogsbane or giant cow parsley,[6] is a plant in the family Apiaceae. In New Zealand, it is also sometimes called wild parsnip,[2] or wild rhubarb.[2] It typically grows to heights of 25.5m (6ft 7in18ft 1in).[7] Superficially, it resembles common hogweed (Heracleum sphondylium), Heracleum sosnowskyi, or garden angelica (Angelica archangelica). It is phototoxic and considered to be a noxious weed in many jurisdictions. Giant hogweed is native to the Caucasus region and Central Asia. It was introduced to Britain as an ornamental plant in the 19th century, and it has also spread to many other parts of Europe, the United States, and Canada.

The sap of giant hogweed causes phytophotodermatitis in humans, resulting in blisters and long-lasting scars. These serious reactions are due to the furocoumarin derivatives in the leaves, roots, stems, flowers, and seeds of the plant.

Giant hogweed has a stout, bright green stem that is frequently spotted with dark red and hollow red-spotted leaf stalks that produce sturdy bristles. The stems grow to more than 2 m high.[8] The hollow stems vary from 38cm (1.23.1in) in diameter, occasionally up to 10cm (3.9in). Each dark red spot on the stem surrounds a hair, and large, coarse white hairs occur at the base of the leaf stalk. The plant has deeply incised compound leaves which grow up to 11.7m (3ft 3in5ft 7in) in width.

Giant hogweed is a biennial or monocarpic perennial,[7]:827 the plants usually begin dying after they have set seed. It usually flowers in its second year from late spring to midsummer, with numerous white flowers clustered in an umbrella-shaped head that is up to 80cm (31in) in diameter across its flat top. The plant produces 1,500 to 100,000 flattened, 1-centimetre (0.39in)-long, oval, dry seeds that have a broadly rounded base and broad marginal ridges. Tall dead stems may mark its locations during winter.

Giant hogweed was among many foreign plants introduced to Britain in the 19th century as ornamental plants. It is now widespread throughout the British Isles, especially along riverbanks. By forming dense stands, they can displace native plants and reduce wildlife habitats.[9] It has spread in the northeastern and northwestern United States, and southern Canada and is an invasive species in Germany, France, and Belgium, overtaking the local native species, Heracleum sphondylium.[9]

In Canada, the plant has been sighted in British Columbia, Alberta, Saskatchewan, Ontario, Quebec, New Brunswick, Nova Scotia, and in isolated areas of Newfoundland. It has been seen in Quebec since the early 1990s.[10] The plant's spread in Ontario began in the southwest and was seen in 2010 in the greater Toronto area and Renfrew County near Ottawa.[11]

Giant hogweed was introduced into New York about 1917, and was recorded in British Columbia in the 1930s. It now occurs in the west in British Columbia, Washington, and Oregon and in eastern North America from Newfoundland and Nova Scotia west to Ontario and Wisconsin and south to Indiana, Maryland, and New Jersey.[12][13] It is also recorded occasionally in Michigan[14] It is a federally listed noxious weed in many states.[12]

The sap of the giant hogweed plant is phototoxic; when the contacted skin is exposed to sunlight or to ultraviolet rays, it can cause phytophotodermatitis (severe skin inflammations). Initially, the skin colours red and starts itching. Blisters form as it burns within 48 hours. They form black or purplish scars that can last several years. Hospitalisation may be necessary.[9] Although many media reports on giant hogweed suggest the plant can lead to temporary or permanent blindness, existing research on the plant does not back up this claim.[15]

These reactions are caused by the presence of linear derivatives of furanocoumarin in its leaves, roots, stems, flowers, and seeds. These chemicals can get into the nucleus of the epithelial cells, forming a bond with the DNA, causing the cells to die. The brown colour is caused by the production of melanin by furocoumarins.

Authorities advise that children should be kept away from giant hogweed, that protective clothing, including eye protection, should be worn when handling or digging it, and that if skin is exposed, the affected area should be washed thoroughly with soap and water and the exposed skin protected from the sun for several days.[9]

Because of its phototoxicity and invasive nature, giant hogweed is often actively removed. In the UK, the Wildlife and Countryside Act 1981 makes it an offence to plant or cause giant hogweed to grow in the wild.[9][16] Hogweed is regulated as a federal noxious weed by the US government, and is illegal to import into the United States or move interstate without a permit from the Department of Agriculture.[17] The USDA Forest Service states pigs and cattle can eat it without apparent harm.[5] The New York State Department of Environmental Conservation has had an active program to control giant hogweed since 2008, including reporting, database maintenance, and crews for removal or herbicide control.[18][19] In 2011, Maine state horticulturists, describing the plant as "Queen Anne's lace on steroids", reported that it has been found at 21 different locations in Maine, with the number of plants ranging from one to a hundred.[20]

The 1971 album Nursery Cryme by the progressive rock group Genesis contains a song called "The Return of the Giant Hogweed". The lyrics describe a murderous attack on the human race by Heracleum mantegazzianum, long after the plant was first "captured" and brought to England by a Victorian explorer.[21] It is typical of the dramatic, tongue-in-cheek humour prevalent in the band's early recordings. A live version can be found on their 1973 Genesis Live album.

The 1971 studio recording appears in Series 1 Episode 1 ("And No Birds Sing") of the British TV crime drama Rosemary and Thyme as the episode story centres around hogweed.

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Blindness (Movie Tie-In) by Jos Saramago | 2900156035582 …

Tuesday, November 29th, 2016

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Winner of the 1998 Nobel Prize for Literature. A city is hit by an epidemic of 'white blindness.' The blindness spreads, sparing no one. Authorities confine the blind to a vacant mental hospital secured by armed guards. Inside, the criminal element among the blind hold the rest captive: food rations are stolen, women are raped. There is one eyewitness to this nightmare who guides seven strangers through the barren streets. The developments within this oddly anonymous group -- the first blind man, the old man with the black eye patch, the girl with dark glasses, the boy with no mother, and the dog of tears -- are as uncanny as the surrounding chaos is harrowing.

A parable of loss and disorientation, of man's worst appetities and hopeless weaknesses, Blindness is one of the most challenging, thought-provoking, and ultimately exhilarating novels published in any language in recent years.

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Blindness – Sensory Birth Defects – Medic8

Tuesday, November 29th, 2016

Birth defects affect the structure or function of parts or systems in the body and this can result in many different developmental and health problems. Birth defects which affect the sensory organs are known as sensory birth defects; the most common examples include cataracts, visual impairment, blindness and hearing loss.

Blindness rarely develops during the teenage and early adult years; most people are either born with blindness or develop it as a result of other visual problems which get worse as they age. In some rare cases, blindness may also result from an accident or injury or exposure to a harmful chemical. Blindness that exists from birth is known as congenital blindness; in this case, the baby will probably never be able to see. There are different degrees of visual impairment and some people who have a birth defect which affects the sensory organs only suffer from mild visual impairment.

There may be many different causes of congenital blindness and visual problems; possible causes are outlined below:

Blindness can also be caused by existing conditions, which become worse over time; examples of these conditions include glaucoma and cataracts, which may be common symptoms of birth defects.

Being blind does not have any impact on intellectual capacity but it may make learning more difficult because so much of our learning and development is aided by seeing the world around us. Blind children and adults tend to rely on their other senses, particularly their hearing and touch to guide them and enable them to learn. Using Braille and other tangible objects enables blind people to do everyday activities such as crossing the road, making a phone call or reading a book; Braille uses small tangible dots and bumps that can spell out words or replace letters or numbers. Audio books enable blind people to listen to books, rather than reading them and hearing can also be very beneficial for things like communicating with others and keeping safe when out and about.

Many children with visual impairment attend regular schools, although there are many specialist schools which cater for children with more severe visual problems and blindness. At school, pupils should be given additional support and the school should cater for them by providing Braille equipment and ensuring the surroundings are suitable and safe.

As mentioned above, many people rely on their other senses to get around and live a normal daily life; however, there are additional aids which can help to make life easier. Braille, as e have already established, is hugely beneficial for blind people; it allows them to do everything from making a telephone call and reading a book, to understanding forms and letters. Many blind people also benefit from having a specially trained guide dog; these dogs help to enable people to stay relatively independent and keep them safe when they are crossing roads or are out and about walking.

There is currently no cure for blindness and those born with blindness will have to face the reality of never being able to see; this is a strange, frightening concept for people who have good sight. There are treatments available for some visual conditions; however, not all problems are curable. If you are born with a visual impairment, your doctor or ophthalmologist will discuss all the possible options and treatment pathways with you.

Scientists and researchers are currently working on numerous projects to identify measures and treatments which can cure congenital blindness; one of the methods being trialled is gene therapy.

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Blindness Wikipdia

Thursday, November 24th, 2016

Un article de Wikipdia, l'encyclopdie libre.

Blindness, ou L'Aveuglement[1] au Qubec, est un film de science-fiction japono-canado-brsilien ralis par Fernando Meirelles, sorti en 2008.

Il s'agit de l'adaptation du roman Ensaio sobre a Cegueira (1995) de l'crivain portugais Jos Saramago, rcompens par le prix Nobel de littrature en 1998[2]. Le film est prsent en comptition officielle au festival de Cannes 2008[3].

Tout commence quand un homme perd subitement la vue alors quil est au volant de sa voiture, attendant que le feu passe au vert. Trs vite, chacune des personnes quil rencontre: le bon samaritain qui le raccompagne chez lui, son mdecin, les autres patients dans la salle d'attente sont frapps de ccit blanche. Seule la femme du mdecin est mystrieusement pargne. Alors que la contagion stend une vitesse fulgurante, la panique gagne la ville. Les victimes de lpidmie sont de plus en plus nombreuses et les autorits les placent en quarantaine dans un hpital dsaffect. La femme du mdecin, dcide rester auprs de son mari, fait croire qu'elle a galement perdu la vue. lhpital, elle tente dorganiser un semblant de vie quotidienne civilise. Lorsque le confinement dgnre en explosion de violence, elle prend la tte de la rvolte et guide une famille improvise travers la ville dvaste.

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Monday, November 14th, 2016

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Perhaps I will write about my interest in psychopharmacology.

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Visual impairment – Wikipedia

Monday, October 31st, 2016

Visual impairment, also known as vision impairment or vision loss, is a decreased ability to see to a degree that causes problems not fixable by usual means, such as glasses.[1][2] Some also include those who have a decreased ability to see because they do not have access to glasses or contact lenses.[1] Visual impairment is often defined as a best corrected visual acuity of worse than either 20/40 or 20/60.[3] The term blindness is used for complete or nearly complete vision loss.[3] Visual impairment may cause people difficulties with normal daily activities such as driving, reading, socializing, and walking.[2]

The most common causes of visual impairment globally are uncorrected refractive errors (43%), cataracts (33%), and glaucoma (2%).[4] Refractive errors include near sighted, far sighted, presbyopia, and astigmatism.[4] Cataracts are the most common cause of blindness.[4] Other disorders that may cause visual problems include age related macular degeneration, diabetic retinopathy, corneal clouding, childhood blindness, and a number of infections.[5] Visual impairment can also be caused by problems in the brain due to stroke, prematurity, or trauma among others.[6] These cases are known as cortical visual impairment.[6] Screening for vision problems in children may improve future vision and educational achievement.[7] Screening adults without symptoms is of uncertain benefit.[8] Diagnosis is by an eye exam.[2]

The World Health Organization (WHO) estimates that 80% of visual impairment is either preventable or curable with treatment.[4] This includes cataracts, the infections river blindness and trachoma, glaucoma, diabetic retinopathy, uncorrected refractive errors, and some cases of childhood blindness.[9] Many people with significant visual impairment benefit from vision rehabilitation, changes in their environmental, and assistive devices.[2]

As of 2012 there were 285 million people who were visually impaired of which 246 million had low vision and 39 million were blind.[4] The majority of people with poor vision are in the developing world and are over the age of 50 years.[4] Rates of visual impairment have decreased since the 1990s.[4] Visual impairments have considerable economic costs both directly due to the cost of treatment and indirectly due to decreased ability to work.[10]

The definition of visual impairment is reduced vision not corrected by glasses or contact lenses. The World Health Organization uses the following classifications of visual impairment. When the vision in the better eye with best possible glasses correction is:

Blindness is defined by the World Health Organization as vision in a person's best eye with best correction of less than 20/500 or a visual field of less than 10 degrees.[3] This definition was set in 1972, and there is ongoing discussion as to whether it should be altered to officially include uncorrected refractive errors.[1]

Severely sight impaired

Sight impaired

Low vision

In the UK, the Certificate of Vision Impairment (CVI) is used to certify patients as severely sight impaired or sight impaired.[12] The accompanying guidance for clinical staff states: "The National Assistance Act 1948 states that a person can be certified as severely sight impaired if they are "so blind as to be unable to perform any work for which eye sight is essential". The test is whether a person cannot do any work for which eyesight is essential, not just his or her normal job or one particular job."[13]

In practice, the definition depends on individuals' visual acuity and the extent to which their field of vision is restricted. The Department of Health identifies three groups of people who may be classified as severely visually impaired.[13]

The Department of Health also state that a person is more likely to be classified as severely visually impaired if their eyesight has failed recently or if they are an older individual, both groups being perceived as less able to adapt to their vision loss.[13]

In the United States, any person with vision that cannot be corrected to better than 20/200 in the best eye, or who has 20 degrees (diameter) or less of visual field remaining, is considered legally blind or eligible for disability classification and possible inclusion in certain government sponsored programs.

In the United States, the terms partially sighted, low vision, legally blind and totally blind are used by schools, colleges, and other educational institutions to describe students with visual impairments.[14] They are defined as follows:

In 1934, the American Medical Association adopted the following definition of blindness:

Central visual acuity of 20/200 or less in the better eye with corrective glasses or central visual acuity of more than 20/200 if there is a visual field defect in which the peripheral field is contracted to such an extent that the widest diameter of the visual field subtends an angular distance no greater than 20 degrees in the better eye.[15]

The United States Congress included this definition as part of the Aid to the Blind program in the Social Security Act passed in 1935.[15][16] In 1972, the Aid to the Blind program and two others combined under Title XVI of the Social Security Act to form the Supplemental Security Income program[17] which states:

An individual shall be considered to be blind for purposes of this title if he has central visual acuity of 20/200 or less in the better eye with the use of a correcting lens. An eye which is accompanied by a limitation in the fields of vision such that the widest diameter of the visual field subtends an angle no greater than 20 degrees shall be considered for purposes of the first sentence of this subsection as having a central visual acuity of 20/200 or less. An individual shall also be considered to be blind for purposes of this title if he is blind as defined under a State plan approved under title X or XVI as in effect for October 1972 and received aid under such plan (on the basis of blindness) for December 1973, so long as he is continuously blind as so defined.[18]

Kuwait is one of many nations that share the 6/60 criteria for legal blindness.[19]

Visual impairments may take many forms and be of varying degrees. Visual acuity alone is not always a good predictor of the degree of problems a person may have. Someone with relatively good acuity (e.g., 20/40) can have difficulty with daily functioning, while someone with worse acuity (e.g., 20/200) may function reasonably well if their visual demands are not great.

The American Medical Association has estimated that the loss of one eye equals 25% impairment of the visual system and 24% impairment of the whole person;[20][21] total loss of vision in both eyes is considered to be 100% visual impairment and 85% impairment of the whole person.[20]

Some people who fall into this category can use their considerable residual vision their remaining sight to complete daily tasks without relying on alternative methods. The role of a low vision specialist (optometrist or ophthalmologist) is to maximize the functional level of a patient's vision by optical or non-optical means. Primarily, this is by use of magnification in the form of telescopic systems for distance vision and optical or electronic magnification for near tasks.

People with significantly reduced acuity may benefit from training conducted by individuals trained in the provision of technical aids. Low vision rehabilitation professionals, some of whom are connected to an agency for the blind, can provide advice on lighting and contrast to maximize remaining vision. These professionals also have access to non-visual aids, and can instruct patients in their uses.

The subjects making the most use of rehabilitation instruments, who lived alone, and preserved their own mobility and occupation were the least depressed, with the lowest risk of suicide and the highest level of social integration.

Those with worsening sight and the prognosis of eventual blindness are at comparatively high risk of suicide and thus may be in need of supportive services. These observations advocate the establishment and extension of therapeutic and preventative programs to include patients with impending and current severe visual impairment who do not qualify for services for the blind. Ophthalmologists should be made aware of these potential consequences and incorporate a place for mental health professionals in their treatment of these types of patients, with a view to preventing the onset of depressive symptomatology, avoiding self-destructive behavior, and improving the quality of life of these patients. Such intervention should occur in the early stages of diagnosis, particularly as many studies have demonstrated how rapid acceptance of the serious visual handicap has led to a better, more productive compliance with rehabilitation programs. Moreover, psychological distress has been reported (and is exemplified by our psychological autopsy study) to be at its highest when sight loss is not complete, but the prognosis is unfavorable.10 Therefore, early intervention is imperative for enabling successful psychological adjustment.[22]

Blindness can occur in combination with such conditions as intellectual disability, autism spectrum disorders, cerebral palsy, hearing impairments, and epilepsy.[23][24] Blindness in combination with hearing loss is known as deafblindness.

It has been estimated that over half of totally blind people have non-24-hour sleepwake disorder, a condition in which a person's circadian rhythm, normally slightly longer than 24 hours, is not entrained (re-set) to the light/dark cycle.[25][26]

The most common causes of visual impairment globally in 2010 were:

The most common causes of blindness in 2010 were:

About 90% of people who are visually impaired live in the developing world.[4] Age-related macular degeneration, glaucoma, and diabetic retinopathy are the leading causes of blindness in the developed world.[27]

Of these, cataract is responsible for >65%, or more than 22 million cases of blindness, and glaucoma is responsible for 6 million cases.

Cataracts: is the congenital and pediatric pathology that describes the greying or opacity of the crystalline lens, which is most commonly caused by intrauterine infections, metabolic disorders, and genetically transmitted syndromes.[28] Cataracts are the leading cause of child and adult blindness that doubles in prevalence with every ten years after the age of 40.[29] Consequently, today cataracts are more common among adults than in children.[28] That is, people face higher chances of developing cataracts as they age. Nonetheless, cataracts tend to have a greater financial and emotional toll upon children as they must undergo expensive diagnosis, long term rehabilitation, and visual assistance.[30] Also, according to the Saudi Journal for Health Sciences, sometimes patients experience irreversible amblyopia[28] after pediatric cataract surgery because the cataracts prevented the normal maturation of vision prior to operation.[31] Despite the great progress in treatment, cataracts remain a global problem in both economically developed and developing countries.[32] At present, with the variant outcomes as well as the unequal access to cataract surgery, the best way to reduce the risk of developing cataracts is to avoid smoking and extensive exposure to sun light (i.e. UV-B rays).[29]

Glaucoma is a congenital and pediatric eye disease characterized by increased pressure within the eye or intraocular pressure (IOP).[33] Glaucoma causes visual field loss as well as severs the optic nerve.[34] Early diagnosis and treatment of glaucoma in patients is imperative because glaucoma is triggered by non-specific levels of IOP.[34] Also, another challenge in accurately diagnosing glaucoma is that the disease has four etiologies: 1) inflammatory ocular hypertension syndrome (IOHS); 2) severe uveitic angle closure; 3) corticosteroid-induced; and 4) a heterogonous mechanism associated with structural change and chronic inflammation.[33] In addition, often pediatric glaucoma differs greatly in etiology and management from the glaucoma developed by adults.[35] Currently, the best sign of pediatric glaucoma is an IOP of 21mm Hg or greater present within a child.[35] One of the most common causes of pediatric glaucoma is cataract removal surgery, which leads to an incidence rate of about 12.2% among infants and 58.7% among 10-year-olds.[35]

Childhood blindness can be caused by conditions related to pregnancy, such as congenital rubella syndrome and retinopathy of prematurity. Leprosy and onchocerciasis each blind approximately 1 million individuals in the developing world.

The number of individuals blind from trachoma has decreased in the past 10 years from 6 million to 1.3 million, putting it in seventh place on the list of causes of blindness worldwide.

Central corneal ulceration is also a significant cause of monocular blindness worldwide, accounting for an estimated 850,000 cases of corneal blindness every year in the Indian subcontinent alone. As a result, corneal scarring from all causes is now the fourth greatest cause of global blindness.[36]

Eye injuries, most often occurring in people under 30, are the leading cause of monocular blindness (vision loss in one eye) throughout the United States. Injuries and cataracts affect the eye itself, while abnormalities such as optic nerve hypoplasia affect the nerve bundle that sends signals from the eye to the back of the brain, which can lead to decreased visual acuity.

Cortical blindness results from injuries to the occipital lobe of the brain that prevent the brain from correctly receiving or interpreting signals from the optic nerve. Symptoms of cortical blindness vary greatly across individuals and may be more severe in periods of exhaustion or stress. It is common for people with cortical blindness to have poorer vision later in the day.

Blinding has been used as an act of vengeance and torture in some instances, to deprive a person of a major sense by which they can navigate or interact within the world, act fully independently, and be aware of events surrounding them. An example from the classical realm is Oedipus, who gouges out his own eyes after realizing that he fulfilled the awful prophecy spoken of him. Having crushed the Bulgarians, the Byzantine Emperor Basil II blinded as many as 15,000 prisoners taken in the battle, before releasing them.[37] Contemporary examples include the addition of methods such as acid throwing as a form of disfigurement.

People with albinism often have vision loss to the extent that many are legally blind, though few of them actually cannot see. Leber's congenital amaurosis can cause total blindness or severe sight loss from birth or early childhood.

Recent advances in mapping of the human genome have identified other genetic causes of low vision or blindness. One such example is Bardet-Biedl syndrome.

Rarely, blindness is caused by the intake of certain chemicals. A well-known example is methanol, which is only mildly toxic and minimally intoxicating, and breaks down into the substances formaldehyde and formic acid which in turn can cause blindness, an array of other health complications, and death.[38] When competing with ethanol for metabolism, ethanol is metabolized first, and the onset of toxicity is delayed. Methanol is commonly found in methylated spirits, denatured ethyl alcohol, to avoid paying taxes on selling ethanol intended for human consumption. Methylated spirits are sometimes used by alcoholics as a desperate and cheap substitute for regular ethanol alcoholic beverages.

It is important that people be examined by someone specializing in low vision care prior to other rehabilitation training to rule out potential medical or surgical correction for the problem and to establish a careful baseline refraction and prescription of both normal and low vision glasses and optical aids. Only a doctor is qualified to evaluate visual functioning of a compromised visual system effectively.[45] The American Medical Association provide an approach to evaluating visual loss as it affects an individual's ability to perform activities of daily living.[20]

Screening adults who have no symptoms is of uncertain benefit.[8]

The World Health Organization estimates that 80% of visual loss is either preventable or curable with treatment.[4] This includes cataracts, onchocerciasis, trachoma, glaucoma, diabetic retinopathy, uncorrected refractive errors, and some cases of childhood blindness.[9] The Center for Disease Control and Prevention estimates that half of blindness in the United States is preventable.[2]

Aside from medical help, various sources provide information, rehabilitation, education, and work and social integration.

Many people with serious visual impairments can travel independently, using a wide range of tools and techniques. Orientation and mobility specialists are professionals who are specifically trained to teach people with visual impairments how to travel safely, confidently, and independently in the home and the community. These professionals can also help blind people to practice travelling on specific routes which they may use often, such as the route from one's house to a convenience store. Becoming familiar with an environment or route can make it much easier for a blind person to navigate successfully.

Tools such as the white cane with a red tip the international symbol of blindness may also be used to improve mobility. A long cane is used to extend the user's range of touch sensation. It is usually swung in a low sweeping motion, across the intended path of travel, to detect obstacles. However, techniques for cane travel can vary depending on the user and/or the situation. Some visually impaired persons do not carry these kinds of canes, opting instead for the shorter, lighter identification (ID) cane. Still others require a support cane. The choice depends on the individual's vision, motivation, and other factors.

A small number of people employ guide dogs to assist in mobility. These dogs are trained to navigate around various obstacles, and to indicate when it becomes necessary to go up or down a step. However, the helpfulness of guide dogs is limited by the inability of dogs to understand complex directions. The human half of the guide dog team does the directing, based upon skills acquired through previous mobility training. In this sense, the handler might be likened to an aircraft's navigator, who must know how to get from one place to another, and the dog to the pilot, who gets them there safely.

GPS devices can also be used as a mobility aid. Such software can assist blind people with orientation and navigation, but it is not a replacement for traditional mobility tools such as white canes and guide dogs.

Some blind people are skilled at echolocating silent objects simply by producing mouth clicks and listening to the returning echoes. It has been shown that blind echolocation experts use what is normally the "visual" part of their brain to process the echoes.[46][47]

Government actions are sometimes taken to make public places more accessible to blind people. Public transportation is freely available to the blind in many cities. Tactile paving and audible traffic signals can make it easier and safer for visually impaired pedestrians to cross streets. In addition to making rules about who can and cannot use a cane, some governments mandate the right-of-way be given to users of white canes or guide dogs.

Most visually impaired people who are not totally blind read print, either of a regular size or enlarged by magnification devices. Many also read large-print, which is easier for them to read without such devices. A variety of magnifying glasses, some handheld, and some on desktops, can make reading easier for them.

Others read Braille (or the infrequently used Moon type), or rely on talking books and readers or reading machines, which convert printed text to speech or Braille. They use computers with special hardware such as scanners and refreshable Braille displays as well as software written specifically for the blind, such as optical character recognition applications and screen readers.

Some people access these materials through agencies for the blind, such as the National Library Service for the Blind and Physically Handicapped in the United States, the National Library for the Blind or the RNIB in the United Kingdom.

Closed-circuit televisions, equipment that enlarges and contrasts textual items, are a more high-tech alternative to traditional magnification devices.

There are also over 100 radio reading services throughout the world that provide people with vision impairments with readings from periodicals over the radio. The International Association of Audio Information Services provides links to all of these organizations.

Access technology such as screen readers, screen magnifiers and refreshable Braille displays enable the blind to use mainstream computer applications and mobile phones. The availability of assistive technology is increasing, accompanied by concerted efforts to ensure the accessibility of information technology to all potential users, including the blind. Later versions of Microsoft Windows include an Accessibility Wizard & Magnifier for those with partial vision, and Microsoft Narrator, a simple screen reader. Linux distributions (as live CDs) for the blind include Oralux and Adriane Knoppix, the latter developed in part by Adriane Knopper who has a visual impairment. Mac OS also comes with a built-in screen reader, called VoiceOver.

The movement towards greater web accessibility is opening a far wider number of websites to adaptive technology, making the web a more inviting place for visually impaired surfers.

Experimental approaches in sensory substitution are beginning to provide access to arbitrary live views from a camera.

Modified visual output that includes large print and/or clear simple graphics can be of benefit to users with some residual vision.[48]

Blind people may use talking equipment such as thermometers, watches, clocks, scales, calculators, and compasses. They may also enlarge or mark dials on devices such as ovens and thermostats to make them usable. Other techniques used by blind people to assist them in daily activities include:

Most people, once they have been visually impaired for long enough, devise their own adaptive strategies in all areas of personal and professional management.

For the blind, there are books in braille, audio-books, and text-to-speech computer programs, machines and e-book readers. Low vision people can make use of these tools as well as large-print reading materials and e-book readers that provide large font sizes.

Computers are important tools of integration for the visually impaired person. They allow, using standard or specific programs, screen magnification and conversion of text into sound or touch (Braille line), and are useful for all levels of visual handicap. OCR scanners can, in conjunction with text-to-speech software, read the contents of books and documents aloud via computer. Vendors also build closed-circuit televisions that electronically magnify paper, and even change its contrast and color, for visually impaired users. For more information, consult Assistive technology.

In adults with low vision there is no conclusive evidence supporting one form of reading aid over another.[50] In several studies stand-based closed-circuit television and hand-held closed-circuit television allowed faster reading than optical aids.[50] While electronic aids may allow faster reading for individuals with low vision, portability, ease of use, and affordability must be considered for people.[50]

Children with low vision sometimes have reading delays, but do benefit from phonics-based beginning reading instruction methods. Engaging phonics instruction is multisensory, highly motivating, and hands-on. Typically students are first taught the most frequent sounds of the alphabet letters, especially the so-called short vowel sounds, then taught to blend sounds together with three-letter consonant-vowel-consonant words such as cat, red, sit, hot, sun. Hands-on (or kinesthetically appealing) VERY enlarged print materials such as those found in "The Big Collection of Phonics Flipbooks" by Lynn Gordon (Scholastic, 2010) are helpful for teaching word families and blending skills to beginning readers with low vision. Beginning reading instructional materials should focus primarily on the lower-case letters, not the capital letters (even though they are larger) because reading text requires familiarity (mostly) with lower-case letters. Phonics-based beginning reading should also be supplemented with phonemic awareness lessons, writing opportunities, and lots of read-alouds (literature read to children daily) to stimulate motivation, vocabulary development, concept development, and comprehension skill development. Many children with low vision can be successfully included in regular education environments. Parents may need to be vigilant to ensure that the school provides the teacher and students with appropriate low vision resources, for example technology in the classroom, classroom aide time, modified educational materials, and consultation assistance with low vision experts.

Communication with the visually impaired can be more difficult than communicating with someone who doesn't have vision loss. However, many people are uncomfortable with communicating with the blind, and this can cause communication barriers. One of the biggest obstacles in communicating with visually impaired individuals comes from face-to-face interactions.[51] There are many factors that can cause the sighted to become uncomfortable while communicating face to face. There are many non-verbal factors that hinder communication between the visually impaired and the sighted, more often than verbal factors do. These factors, which Rivka Bialistock[51] mentions in her article, include:

The blind person sends these signals or types of non-verbal communication without being aware that they are doing so. These factors can all affect the way an individual would feel about communicating with the visually impaired. This leaves the visually impaired feeling rejected and lonely.

In the article Towards better communication, from the interest point of view. Orskills of sight-glish for the blind and visually impaired, the author, Rivka Bialistock [51] comes up with a method to reduce individuals being uncomfortable with communicating with the visually impaired. This method is called blind-glish or sight-glish, which is a language for the blind, similar to English. For example, babies, who are not born and able to talk right away, communicate through sight-glish, simply seeing everything and communicating non-verbally. This comes naturally to sighted babies, and by teaching this same method to babies with a visual impairment can improve their ability to communicate better, from the very beginning.

To avoid the rejected feeling of the visually impaired, people need to treat the blind the same way they would treat anyone else, rather than treating them like they have a disability, and need special attention. People may feel that it is improper to, for example, tell their blind child to look at them when they are speaking. However, this contributes to the sight-glish method.[51] It is important to disregard any mental fears or uncomfortable feelings people have while communicating (verbally and non-verbally) face-to-face.

Individuals with a visual disability not only have to find ways to communicate effectively with the people around them, but their environment as well. The blind or visually impaired rely largely on their other senses such as hearing, touch, and smell in order to understand their surroundings.[52]

Sound is one of the most important senses that the blind or visually impaired use in order to locate objects in their surroundings. A form of echolocation is used, similarly to that of a bat.[53] Echolocation from a person's perspective is when the person uses sound waves generated from speech or other forms of noise such as cane tapping, which reflect off of objects and bounce back at the person giving them a rough idea of where the object is. This does not mean they can depict details based on sound but rather where objects are in order to interact, or avoid them. Increases in atmospheric pressure and humidity increase a person's ability to use sound to their advantage as wind or any form of background noise impairs it.[52]

Touch is also an important aspect of how blind or visually impaired people perceive the world. Touch gives immense amount of information in the persons immediate surrounding. Feeling anything with detail gives off information on shape, size, texture, temperature, and many other qualities. Touch also helps with communication; braille is a form of communication in which people use their fingers to feel elevated bumps on a surface and can understand what is meant to be interpreted.[54] There are some issues and limitations with touch as not all objects are accessible to feel, which makes it difficult to perceive the actual object. Another limiting factor is that the learning process of identifying objects with touch is much slower than identifying objects with sight. This is due to the fact the object needs to be approached and carefully felt until a rough idea can be constructed in the brain.[52]

Certain smells can be associated with specific areas and help a person with vision problems to remember a familiar area. This way there is a better chance of recognizing an areas layout in order to navigate themselves through. The same can be said for people as well. Some people have their own special odor that a person with a more trained sense of smell can pick up. A person with an impairment of their vision can use this to recognize people within their vicinity without them saying a word.[52]

Visual impairment can have profound effects on the development of infant and child communication. The language and social development of a child or infant can be very delayed by the inability to see the world around them.

Social development includes interactions with the people surrounding the infant in the beginning of its life. To a child with vision, a smile from a parent is the first symbol of recognition and communication, and is almost an instant factor of communication. For a visually impaired infant, recognition of a parent's voice will be noticed at approximately two months old, but a smile will only be evoked through touch between parent and baby. This primary form of communication is greatly delayed for the child and will prevent other forms of communication from developing. Social interactions are more complicated because subtle visual cues are missing and facial expressions from others are lost.

Due to delays in a child's communication development, they may appear to be disinterested in social activity with peers, non-communicative and un-education on how to communicate with other people. This may cause the child to be avoided by peers and consequently over protected by family members.

With sight, much of what is learned by a child is learned through imitation of others, where as a visually impaired child needs very planned instruction directed at the development of postponed imitation. A visually impaired infant may jabber and imitate words sooner than a sighted child, but may show delay when combining words to say themselves, the child may tend to initiate few questions and their use of adjectives is infrequent. Normally the child's sensory experiences are not readily coded into language and this may cause them to store phrases and sentences in their memory and repeat them out of context. The language of the blind child does not seem to mirror their developing knowledge of the world, but rather their knowledge of the language of others.

A visually impaired child may also be hesitant to explore the world around them due to fear of the unknown and also may be discouraged from exploration by overprotective family members. Without concrete experiences, the child is not able to develop meaningful concepts or the language to describe or think about them.[55]

Visual impairment has the ability to create consequences for health and well being. Visual impairment is increasing especially among older people. It is recognized that those individuals with visual impairment are likely to have limited access to information and healthcare facilities, and may not receive the best care possible because not all health care professionals are aware of specific needs related to vision.

The WHO estimates that in 2012 there were 285 million visually impaired people in the world, of which 246 million had low vision and 39 million were blind.[4]

Of those who are blind 90% live in the developing world.[56] Worldwide for each blind person, an average of 3.4 people have low vision, with country and regional variation ranging from 2.4 to 5.5.[57]

By age: Visual impairment is unequally distributed across age groups. More than 82% of all people who are blind are 50 years of age and older, although they represent only 19% of the world's population. Due to the expected number of years lived in blindness (blind years), childhood blindness remains a significant problem, with an estimated 1.4 million blind children below age 15.

By gender: Available studies consistently indicate that in every region of the world, and at all ages, females have a significantly higher risk of being visually impaired than males.

By geography: Visual impairment is not distributed uniformly throughout the world. More than 90% of the world's visually impaired live in developing countries.[57]

Since the estimates of the 1990s, new data based on the 2002 global population show a reduction in the number of people who are blind or visually impaired, and those who are blind from the effects of infectious diseases, but an increase in the number of people who are blind from conditions related to longer life spans.[57]

In 1987, it was estimated that 598,000 people in the United States met the legal definition of blindness.[58] Of this number, 58% were over the age of 65.[58] In 19941995, 1.3 million Americans reported legal blindness.[59]

To determine which people qualify for special assistance because of their visual disabilities, various governments have specific definitions for legal blindness.[60] In North America and most of Europe, legal blindness is defined as visual acuity (vision) of 20/200 (6/60) or less in the better eye with best correction possible. This means that a legally blind individual would have to stand 20 feet (6.1m) from an object to see itwith corrective lenseswith the same degree of clarity as a normally sighted person could from 200 feet (61m). In many areas, people with average acuity who nonetheless have a visual field of less than 20 degrees (the norm being 180 degrees) are also classified as being legally blind. Approximately ten percent of those deemed legally blind, by any measure, have no vision. The rest have some vision, from light perception alone to relatively good acuity. Low vision is sometimes used to describe visual acuities from 20/70 to 20/200.[61]

The Moche people of ancient Peru depicted the blind in their ceramics.[62]

In Greek myth, Tiresias was a prophet famous for his clairvoyance. According to one myth, he was blinded by the gods as punishment for revealing their secrets, while another holds that he was blinded as punishment after he saw Athena naked while she was bathing. In the Odyssey, the one-eyed Cyclops Polyphemus captures Odysseus, who blinds Polyphemus to escape. In Norse mythology, Loki tricks the blind god Hr into killing his brother Baldr, the god of happiness.

The New Testament contains numerous instances of Jesus performing miracles to heal the blind. According to the Gospels, Jesus healed the two blind men of Galilee, the blind man of Bethsaida, the blind man of Jericho and the man who was born blind.

The parable of the blind men and an elephant has crossed between many religious traditions and is part of Jain, Buddhist, Sufi and Hindu lore. In various versions of the tale, a group of blind men (or men in the dark) touch an elephant to learn what it is like. Each one feels a different part, but only one part, such as the side or the tusk. They then compare notes and learn that they are in complete disagreement.

"Three Blind Mice" is a medieval English nursery rhyme about three blind mice whose tails are cut off after chasing the farmer's wife. The work is explicitly incongruous, ending with the comment Did you ever see such a sight in your life, As three blind mice?

Poet John Milton, who went blind in mid-life, composed On His Blindness, a sonnet about coping with blindness. The work posits that [those] who best Bear [God]'s mild yoke, they serve him best.

The Dutch painter and engraver Rembrandt often depicted scenes from the apocryphal Book of Tobit, which tells the story of a blind patriarch who is healed by his son, Tobias, with the help of the archangel Raphael.[63]

Slaver-turned-abolitionist John Newton composed the hymn Amazing Grace about a wretch who "once was lost, but now am found, Was blind, but now I see." Blindness, in this sense, is used both metaphorically (to refer to someone who was ignorant but later became knowledgeable) and literally, as a reference to those healed in the Bible. In the later years of his life, Newton himself would go blind.

H. G. Wells' story "The Country of the Blind" explores what would happen if a sighted man found himself trapped in a country of blind people to emphasise society's attitude to blind people by turning the situation on its head.

Bob Dylan's anti-war song "Blowin' in the Wind" twice alludes to metaphorical blindness: How many times can a man turn his head // and pretend that he just doesn't see... How many times must a man look up // Before he can see the sky?

Contemporary fiction contains numerous well-known blind characters. Some of these characters can "see" by means of fictitious devices, such as the Marvel Comics superhero Daredevil, who can "see" via his super-human hearing acuity, or Star Trek's Geordi La Forge, who can see with the aid of a VISOR, a fictitious device that transmits optical signals to his brain.

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American Psychological Association (APA)

Saturday, October 29th, 2016

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Psychology's superhero

What's psychology's connection to Wonder Woman, the first feminist crusader?

Eating disorders

Learn about the major kinds of eating disorders and how a psychologist can help.

The discipline gap

Black students feel less welcome at schools with excessive suspensions, study finds.

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The only cure for OCD is expensive, elusive, and scary

October 27, 2016, The Atlantic

Autism study shows benefits when parents get involved

October 26, 2016, CNN

7 ways to know if you're on the right career path

October 25, 2016, Forbes

Teen hackers study considers link to addiction

October 24, 2016, BBC News

Can mental illness be prevented in the womb?

October 22, 2016, NPR

Talking to your therapist about election anxiety

October 20, 2016, The New York Times

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Blindness by Jose Saramago – Powell’s Books

Sunday, October 9th, 2016

Awards

Winner of the 1998 Nobel Prize for Literature A New York Times Notable Book of the Year A Los Angeles Times Best Book of the Year

A devastating and often horrific look at societal breakdown, Blindness is one of the most acclaimed novels from Jos Saramago, Portugal's only Nobel laureate for literature. Far more than a mere dystopian plague novel, Blindness is a metaphorical account of society's basest tendencies in the face of catastrophe. Saramago's magnificently wending sentences and trademark style lend grace and beauty to an otherwise gruesome tale of epidemic chaos. Recommended By Jeremy G., Powells.com

A city is hit by an epidemic of "white blindness" which spares no one. Authorities confine the blind to an empty mental hospital, but there the criminal element holds everyone captive, stealing food rations and raping women. There is one eyewitness to this nightmare who guides seven strangers among them a boy with no mother, a girl with dark glasses, a dog of tears through the barren streets, and the procession becomes as uncanny as the surroundings are harrowing. A magnificent parable of loss and disorientation and a vivid evocation of the horrors of the twentieth century, Blindness has swept the reading public with its powerful portrayal of man's worst appetites and weaknesses and man's ultimately exhilarating spirit. The stunningly powerful novel of man's will to survive against all odds, by the winner of the 1998 Nobel Prize for Literature.

"Beautifully written in a concise, haunting prose...this unsettling, highly original work is essential reading." Library Journal

"Saramago's Blindness is the best novel I've read since Gabriel Garcia Marquez' Love in the Time of Cholera. It is a novel of enormous skill and authority....Like all great books it is simultaneously contemporary and timeless, and ambitiously confronts the human condition without a false note struck anywhere. Saramago is one of the great writers of our time, and Blindness, ironically is the product of his extraordinary vision." David Guterson, author of Snow Falling on Cedars

"Blindness may be as revolutionary in its own way and time as were, say, The Trial and The Plague were in theirs. Another masterpiece." Kirkus Reviews, starred review

"Saramago writes phantasmagoria in the midst of the most astonishing fantasy he has a meticulous sense of detail. It's very eloquent stuff." Harold Bloom, author of The Western Canon

"It is the voice of Blindness that gives it its charm. By turns ironic, humorous and frank, there is a kind of wink of humor between author and reader that is perfectly imbued with fury at the excesses of the current century. Blindness reminds me of Kafka roaring with laughter as he read his stories to his friends....Blindness' impact carries the force of an author whose sensibility is significant." The Washington Post

"Blindness is a shattering work by a literary master." The Boston Globe

"More frightening than Stephen King, as unrelenting as a bad dream, Jos Saramago's Blindness politely rubs our faces in apocalypse....A metaphor like 'white blindness' might easily seem forced or labored, but Saramago makes it live by focusing on the stubbornly literal; his account of a clump of newly blind people trying to find their way to food or to the bathroom provides some surprisingly gripping passages. While this epidemic has a clear symbolic burden, it's also a real and very inconvenient affliction." Salon

In Blindness, a city is overcome by an epidemic of blindness that spares only one woman. She becomes a guide for a group of seven strangers and serves as the eyes and ears for the reader in this profound parable of loss and disorientation. We return to the city years later in Saramagos Seeing, a satirical commentary on government in general and democracy in particular. Together here for the first time, this beautiful edition will be a welcome addition to the library of any Saramago fan.

Jos Saramago (1922-2010) was the author of many novels, among them Blindness, All the Names, Baltasarand Blimunda, and The Year of the Death of Ricardo Reis. In 1998 he was awarded the Nobel Prize for Literature.

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Color Blindness – Topic Overview – WebMD

Sunday, September 11th, 2016

Color blindness means that you have trouble seeing red, green, or blue or a mix of these colors. It's rare that a person sees no color at all.

Color blindness is also called a color vision problem.

A color vision problem can change your life. It may make it harder to learn and read, and you may not be able to have certain careers. But children and adults with color vision problems can learn to make up for their problems seeing color.

Most color vision problems are inherited (genetic) and are present at birth.

People usually have three types of cone cells in the eye. Each type senses either red, green, or blue light. You see color when your cone cells sense different amounts of these three basic colors. The highest concentration of cone cells are found in the macula, which is the central part of the retina .

Inherited color blindness happens when you don't have one of these types of cone cells or they don't work right. You may not see one of these three basic colors, or you may see a different shade of that color or a different color. This type of color vision problem doesn't change over time.

A color vision problem isn't always inherited. In some cases, a person can have an acquired color vision problem. This can be caused by:

The symptoms of color vision problems vary:

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Optical Illusions and Visual Phenomena – Bach

Thursday, August 4th, 2016

are fascinating! They also teach us about our visual perception, and its limitations. Emphasis here is on beauty, interactive experiments, and attempts at explanation of the visual mechanisms involved.

Dont let it irk you if you dont see all the phenomena described. For many illusions, there is a percentage of people with perfectly normal vision who just dont see it, often for reasons currently unknown.

If you are not a vision scientist, you might find my explanatory attempts too highbrow. That is not on purpose, but vision research is not trivial, like any science. So, if the explanation seems gibberish, simply enjoy the phenomenon ;). More: Bach & Poloschek (2006) OpticalIllusionsPrimer; on the programming: Bach (2014, PDF).

Optical illusion sounds pejorative, as if exposing a malfunction of the visual system. Rather, I view these phenomena as highlighting particular good adaptations of our visual system to experience with standard viewing situations. These experiences are based on normal visual experiences, and thus under unusual contexts can lead to inappropriate interpretations of a visual scene (=Bayesian interpretation of perception).

Before we delve in, Id like to express my thanks for your @feedback ; any advice is appreciated .

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Editas CEO Katrine Bosley Predicts First CRISPR Human …

Thursday, August 4th, 2016

A biotechnology company says it will test advanced gene-engineering methods to treat blindness.

Editas CEO Katrine Bosley

The biotechnology startup Editas Medicine intends to begin tests of a powerful new form of gene repair in humans within two years.

Speaking this week at the EmTech conference in Cambridge, Massachusetts, Editas CEO Katrine Bosley said the company hopes to start a clinical trial in 2017 to treat a rare form of blindness using CRISPR, a groundbreaking gene-editing technology.

If Editass plans move forward, the study would likely be the first to use CRISPR to edit the DNA of a person.

CRISPR technology was invented just three years ago but is so precise and cheap to use it has quickly spread through biology laboratories. Already, scientists have used it to generate genetically engineered monkeys, and the technique has stirred debate over whether modified humans are next (see Engineering the Perfect Baby).

Editas is one of several startups, including Intellia Therapeutics and CRISPR Therapeutics, that have plans to use the technique to correct DNA disorders that affect children and adults. Bosley said that because CRISPR can repair broken genes it holds promise for treating several thousand inherited disorders caused by gene mistakes, most of which, like Huntingtons disease and cystic fibrosis, have no cure.

Editas, which had not previously given a timeline for an initial human test of CRISPR, will try to treat one form of a rare eye disease called Leber congenital amaurosis, which affects the light-receiving cells of the retina.

The condition Editas is targeting affects only about 600 people in the U.S., says Jean Bennet, director of advanced retinal and ocular therapeutics at the University of Pennsylvanias medical school. The target that they have selected is fantastic; it has all the right characteristics in terms of making a correction easily, says Bennett, who isnt involved in the Editas study.

Children with LCA are born seeing only large, bright shapes, and infants are diagnosed when they dont look into their mothers eyes or react to colorful balloons. Their poor vision can progress to stone cold blindness where everything is black, says Bennett.

Editas picked the disease in part because it is relatively easy to address with CRISPR, Bosley said. The exact gene error is known, and the eye is easy to reach with genetic treatments. It feels fast, but we are going at the pace science allows, she said. There are still questions about how well gene-editing will work in the retina and whether side effects could be caused by unintentional changes to DNA.

Editas plans to deliver the CRISPR technology as a gene therapy. The treatment will involve injecting into the retina a soup of viruses loaded with the DNA instructions needed to manufacture the components of CRISPR, including a protein that can cut a gene at a precise location. Bosley said in order to treat LCA, the company intends to delete about 1,000 DNA letters from a gene called CEP290 in a patients photoreceptor cells.

After the edit, preliminary lab experiments show, the gene should function correctly again. Bosley said Editas still needs to test the approach further in the lab and in animals before a human study starts.

Editas was created by venture capital funds including Third Rock Ventures in 2013 and was cofounded by scientists including Feng Zhang of the MIT/Harvard Broad Institute. It has raised more than $160 million in capital, allowing it to pursue ideas for several treatments simultaneously, Bosley said.

Although the Editas study could be the first for CRISPR in humans, it wouldnt be the first clinical study of gene editing. An older method called zinc fingers is already in testing to treat HIV infection by the biotechnology company Sangamo Biosciences. But the versatility and ease with which CRISPR can change DNA means it may outpace earlier approaches.

Theoretically, gene editing could be used to repair broken genes in any part of the body. But in practice it is difficult to make DNA repairs in most cell types, such as brain cells. The eye is an exception because doctors can inject treatment directly under the retina.

There is already a gene-therapy treatment for one form of LCA in late-stage clinical testing by Philadelphia biotech Spark Therapeutics, says Bennett, who helped develop that treatment. In that case, an entire, healthy version of a gene is being added to eye cells. Typically, gene therapy can only add genes, not edit them.

LCA has several different genetic causes, and standard gene therapy wont work for the form of the disease Editas is looking at. That is because the required gene, CEP290, is too big to fit inside a virus, says Bennett, and so there is no easy way to add it.

By targeting an exceptionally rare illness, Editas may have an easier time getting a treatment tested and approved. However, the eventual cost of such a treatment could be extraordinarily high, given the small number of people who would need it. Bennett says only around 3,000 Americans have LCA, and about 20 percent of those have the form being targeted by Editas.

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WHO | Measles

Thursday, August 4th, 2016

Key facts

Measles is a highly contagious, serious disease caused by a virus. In 1980, before widespread vaccination, measles caused an estimated 2.6 million deaths each year.

The disease remains one of the leading causes of death among young children globally, despite the availability of a safe and effective vaccine. Approximately 114900 people died from measles in 2014 mostly children under the age of 5.

Measles is caused by a virus in the paramyxovirus family and it is normally passed through direct contact and through the air. The virus infects the mucous membranes, then spreads throughout the body. Measles is a human disease and is not known to occur in animals.

Accelerated immunization activities have had a major impact on reducing measles deaths. During 2000-2014, measles vaccination prevented an estimated 17.1 million deaths. Global measles deaths have decreased by 79% from an estimated 546800 in 2000 to 114900 in 2014.

The first sign of measles is usually a high fever, which begins about 10 to 12 days after exposure to the virus, and lasts 4 to 7 days. A runny nose, a cough, red and watery eyes, and small white spots inside the cheeks can develop in the initial stage. After several days, a rash erupts, usually on the face and upper neck. Over about 3 days, the rash spreads, eventually reaching the hands and feet. The rash lasts for 5 to 6 days, and then fades. On average, the rash occurs 14 days after exposure to the virus (within a range of 7 to 18 days).

Most measles-related deaths are caused by complications associated with the disease. Complications are more common in children under the age of 5, or adults over the age of 20. The most serious complications include blindness, encephalitis (an infection that causes brain swelling), severe diarrhoea and related dehydration, ear infections, or severe respiratory infections such as pneumonia. Severe measles is more likely among poorly nourished young children, especially those with insufficient vitamin A, or whose immune systems have been weakened by HIV/AIDS or other diseases.

In populations with high levels of malnutrition and a lack of adequate health care, up to 10% of measles cases result in death. Women infected while pregnant are also at risk of severe complications and the pregnancy may end in miscarriage or preterm delivery. People who recover from measles are immune for the rest of their lives.

Unvaccinated young children are at highest risk of measles and its complications, including death. Unvaccinated pregnant women are also at risk. Any non-immune person (who has not been vaccinated or was vaccinated but did not develop immunity) can become infected.

Measles is still common in many developing countries particularly in parts of Africa and Asia. The overwhelming majority (more than 95%) of measles deaths occur in countries with low per capita incomes and weak health infrastructures.

Measles outbreaks can be particularly deadly in countries experiencing or recovering from a natural disaster or conflict. Damage to health infrastructure and health services interrupts routine immunization, and overcrowding in residential camps greatly increases the risk of infection.

The highly contagious virus is spread by coughing and sneezing, close personal contact or direct contact with infected nasal or throat secretions.

The virus remains active and contagious in the air or on infected surfaces for up to 2 hours. It can be transmitted by an infected person from 4 days prior to the onset of the rash to 4 days after the rash erupts.

Measles outbreaks can result in epidemics that cause many deaths, especially among young, malnourished children. In countries where measles has been largely eliminated, cases imported from other countries remain an important source of infection.

No specific antiviral treatment exists for measles virus.

Severe complications from measles can be avoided through supportive care that ensures good nutrition, adequate fluid intake and treatment of dehydration with WHO-recommended oral rehydration solution. This solution replaces fluids and other essential elements that are lost through diarrhoea or vomiting. Antibiotics should be prescribed to treat eye and ear infections, and pneumonia.

All children in developing countries diagnosed with measles should receive two doses of vitamin A supplements, given 24 hours apart. This treatment restores low vitamin A levels during measles that occur even in well-nourished children and can help prevent eye damage and blindness. Vitamin A supplements have been shown to reduce the number of deaths from measles by 50%.

Routine measles vaccination for children, combined with mass immunization campaigns in countries with high case and death rates, are key public health strategies to reduce global measles deaths. The measles vaccine has been in use for over 50 years. It is safe, effective and inexpensive. It costs approximately one US dollar to immunize a child against measles.

The measles vaccine is often incorporated with rubella and/or mumps vaccines in countries where these illnesses are problems. It is equally effective in the single or combined form. Adding rubella to measles vaccine increases the cost only slightly, and allows for shared delivery and administration costs.

In 2014, about 85% of the world's children received 1 dose of measles vaccine by their first birthday through routine health services up from 73% in 2000. Two doses of the vaccine are recommended to ensure immunity and prevent outbreaks, as about 15% of vaccinated children fail to develop immunity from the first dose.

In 2010, the World Health Assembly established 3 milestones towards the future eradication of measles to be achieved by 2015:

By 2014, the global push to improve vaccine coverage resulted in a 79% reduction in deaths. During 2000-2014, with support from the Measles & Rubella Initiative, measles vaccination prevented an estimated 17.1 million. During 2014, about 219 million children were vaccinated against measles during mass vaccination campaigns in 28 countries. All WHO Regions have now established goals to eliminate this preventable killer disease by 2020.

Launched in 2001, the Measles & Rubella Initiative (M&R Initiative) is a global partnership led by the American Red Cross, United Nations Foundation, Centers for Disease Control and Prevention (CDC), UNICEF and WHO. The M&R Initiative is committed to ensuring that no child dies from measles or is born with congenital rubella syndrome; reducing measles deaths by 95% by 2015; and achieving measles and rubella elimination in at least 5 WHO regions by 2020.

In 2012, the M&R Initiative launched a new Global Measles and Rubella Strategic Plan which covers the period 2012-2020.

The Plan provides clear strategies for country immunization managers, working with domestic and international partners, to achieve the 2015 and 2020 measles and rubella control and elimination goals.

Based on current trends of measles vaccination coverage and incidence, the WHO Strategic Advisory Group of Experts on Immunization (SAGE) concluded that the 2015 global milestones and measles elimination goals will not be achieved on time.

Measles is highly infectious and strong, sustained efforts are needed to maintain the current level of control. Improving coverage in the Democratic Republic of the Congo, Ethiopia, India and other high-burden countries will require changes in policies and practices that currently prevent vaccination of children 12 months of age or older.

To assess the reasons for the slowdown in progress since 2010 and to modify current strategies as needed, the Measles & Rubella Initiative partners have commissioned a mid-term strategy review.

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Blindness by Jos Saramago Reviews, Discussion …

Thursday, August 4th, 2016

From Nobel Prizewinning author Jos Saramago, a magnificent, mesmerizing parable of loss

A city is hit by an epidemic of "white blindness" that spares no one. Authorities confine the blind to an empty mental hospital, but there the criminal element holds everyone captive, stealing food rations and assaulting women. There is one eyewitness to this nightmare who guides her c

A city is hit by an epidemic of "white blindness" that spares no one. Authorities confine the blind to an empty mental hospital, but there the criminal element holds everyone captive, stealing food rations and assaulting women. There is one eyewitness to this nightmare who guides her chargesamong them a boy with no mother, a girl with dark glasses, a dog of tearsthrough the barren streets, and their procession becomes as uncanny as the surroundings are harrowing. As Blindness reclaims the age-old story of a plague, it evokes the vivid and trembling horrors of the twentieth century, leaving readers with a powerful vision of the human spirit that's bound both by weakness and exhilarating strength.

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Prevention of Blindness and Visual Impairment – WHO

Thursday, August 4th, 2016

The global eye health action plan 20142019 aims to reduce avoidable visual impairment as a global public health problem and to secure access to rehabilitation services for the visually impaired. This should be achieved by expanding current efforts by Member States, the WHO Secretariat and international partners, improved coordination, efficient monitoring, focusing the use of resources towards the most cost-effective interventions, and developing innovative approaches to prevent and cure eye diseases.

Blindness is the inability to see. The leading causes of chronic blindness include cataract, glaucoma, age-related macular degeneration, corneal opacities, diabetic retinopathy and eye conditions in children (e.g. caused by vitamin A deficiency). Age-related blindness is increasing throughout the world, as is blindness due to uncontrolled diabetes. On the other hand, blindness caused by infection is decreasing, as a result of public health action. Three-quarters of all blindness can be prevented or treated.

The magnitude of visual impairment and blindness and their causes have been estimated, globally and by WHO region from recent data. For countries without data estimates were based on newly developed model. Globally the number of people of all ages visually impaired is estimated to be 285 million, of whom 39 million are blind. People 50 years and older are 82% of all blind. The major causes of visual impairment are uncorrected refractive errors (43%) and cataract (33%); the first cause of blindness is cataract (51%). Visual impairment in 2010 is a major global health issue: the preventable causes are as high as 80% of the total global burden.

Visual impairment often limits peoples ability to perform everyday tasks and affects their quality of life. Blindness, the most severe form of visual impairment, reduces peoples ability to move about unaided unless properly trained.

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