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Archive for the ‘Integrative Medicine’ Category

Teens’ technology use and mental health: New report from the Connected Learning Lab provides insight into Youth Connections for Wellbeing – PR Web

Tuesday, June 23rd, 2020

We found that misplaced fears are deflecting attention from other real concerns, resulting in missed opportunities for leveraging technology and online communication to address adolescent mental health problems.

IRVINE, Calif. (PRWEB) June 23, 2020

With or without physical separation due to COVID-19, youth are using social media to connect and support each other, according to a report released today. Three leading researchers have just published Youth Connections for Wellbeing, an integrative review paper that illuminates how teens support each other through digital media during times of stress and isolation.

Leveraging their expertise across the fields of cultural anthropology, developmental psychology, and clinical psychology, scholars Mimi Ito, Candice Odgers, and Stephen Schueller discuss the potential of digital media to support youth wellbeing.

The work underlying the paper was completed prior to the COVID-19 global pandemic. The physical isolation that has resulted from shelter-in-place orders has yielded a seismic shift, making it even more critical to understand and leverage technology in a way that benefits youth.

The position paper summarizes current knowledge and redirects the conversation about adolescent social media use and wellbeing in three ways that are particularly relevant today:

1. Refocusing the debate over the relationship between youth social media use and wellbeing to reflect existing evidence, varied youth perspectives and backgrounds.

2. Identifying teen vulnerabilities and assets that may influence problematic and healthy social media engagement.

3. Suggesting opportunities where youth social engagement might mitigate vulnerabilities and leverage assets.

In the position paper Ito, Odgers, and Schueller highlight the need to move beyond the simple question of whether more time spent using social media causes mental health problems in adolescents. Instead, people should consider the specific forms of social media engagement that amplify or mitigate mental health risks for different adolescents. The team integrates findings from existing large-scale reviews, the voices of youth who have grown up on social media, and a systematic review of digital mental health apps available for youth.

The team finds that adolescents online risks often mirror offline vulnerabilities. They note that it is particularly important for messages, interventions, and strategies to be targeted and tailored to the most vulnerable youth and those underserved by traditional mental health services.

A number of relevant findings, opportunities, and benefits are outlined in the paper, including:

For example, one student interviewed shared how they experienced a supportive community online, saying: I think a lot of my mutuals on Instagram, they're very open to being emotionally vulnerable on Instagram, so they'll actually say, I'm not doing fine. I like it because it's a very nice community, just spreading love whether it be through comments or someone will actually say through messages like, Are you okay?

A freshman adjusting to life away from family shared how online connections made her feel close to them: My mother just started using Messenger. I taught her how to use it. And so she texts me here and there. She's like, Good morning, or, How are you doing?, and then we FaceTime. Then my siblings, we use Instagram because that's where we're mostly at. We send each other videos and memes, and then we kind of comment just to make our day.

Given the rising rates of mental health concerns among young people in the U.S., Ito, Odgers, and Schueller encourage a sense of urgency in focusing research, investment, and public attention on how digital spaces and tools can be better designed and used to support youth's mental health.

The paper, which was supported by Pivotal Ventures (https://www.pivotalventures.org/), a Melinda Gates Company, was published by the Connected Learning Lab at the University of California, Irvine, and is available at https://youthwellbeing.online/ReportRelease.

About the Authors

Mimi Ito is a learning scientist and a cultural anthropologist of technology use, examining children and youths changing relationships to media and communications. She is Director of the Connected Learning Lab, Professor in Residence and John D. and Catherine T. MacArthur Foundation Chair in Digital Media and Learning at the University of California, Irvine.

Candice Odgers is a developmental psychologist who studies adolescent mental health and how digital technologies can be leveraged to understand and support wellbeing. She is the Co-Director of the Child and Brain Development Program at the Canadian Institute for Advanced Research, a Professor of Psychological Science at University of California, Irvine, and a Research Professor at Duke University.

Stephen Schueller is a clinical psychologist and mental health service researcher who focuses on using technology to expand access to and improve the accessibility of mental health services. He is an Assistant Professor of Psychological Science at the University of California, Irvine, and an Adjunct Assistant Professor of Preventive Medicine at Northwestern University, Feinberg School of Medicine.

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From warning on dexamethasone to HCQ: Latest on Covid-19 treatment, vaccines – Hindustan Times

Tuesday, June 23rd, 2020

More than 8.4 million people have contracted the coronavirus disease (Covid-19) and 453,290 have died across the world in nearly six months after it was first reported from Chinas Wuhan late last year.

Around 10 potential vaccines are now undergoing trials in humans, in the hope that a shot to prevent infection can become available in coming months. And even before any vaccines have been proven to work, several countries have already begun making deals with pharmaceutical companies to order doses.

The World Health Organization (WHO) hopes hundreds of millions of doses of coronavirus vaccine can be produced this year and 2 billion doses by the end of 2021, chief scientist Soumya Swaminathan said on Thursday.

The WHO is drawing up plans to help decide who should get the first doses once a vaccine is approved, she said.

Priority would be given to frontline workers such as medics, those who are vulnerable because of age or other illness, and those who work or live in high-transmission settings such as prisons and care homes.

Here are all the latest updates you need to know about Covid-19 vaccines:

Caution on dexamethasone

Dexamethasone, a cheap steroid that can help save the lives of patients with severe Covid-19, should be reserved for serious cases in which it has been shown to provide benefits, the World Health Organization (WHO) has warned.

Mike Ryan, the head of the WHOs emergencies programme, said the drug should only be used in those serious cases where it has been shown to help.

It is exceptionally important in this case, that the drug is reserved for use in severely ill and critical patients who can benefit from this drug clearly, Ryan said during a briefing.

Trial results announced on Tuesday by researchers in Britain showed dexamethasone, a generic drug used since the 1960s to reduce inflammation in diseases such as arthritis, cut death rates by around a third among the most severely ill coronavirus patients admitted to hospital.

The research body involved in the trial was the same one which found evidence that HCQ (Hydroxychloroquine) was not extremely effective on all Covid-19 patients.

That makes it the first drug proved to save lives in fighting the disease. However, some doctors were cautious, citing possible side-effects and asking to see more data.

Volunteers lining up to be infected

Thousands are signing up to take part in a high-stakes experiment willing to deliberately expose themselves to the coronavirus to test a potential vaccine, should researchers decide to proceed.

Known as human-challenge studies, these tests can hasten research by placing volunteers in the path of the virus, rather than waiting for accidental exposure.

Pascal Soriot, chief executive officer of drugmaker AstraZeneca Plc, said the controversial approach may become necessary at some point as the disease ebbs in some cities, making it harder to evaluate shots in the more conventional way.

The company is working with the University of Oxford on one of the most advanced vaccines against the virus.

The initiative is organized by 1DaySooner, a group that advocates on behalf of people who want to join challenge studies. The organisation has held discussions with potential partners and vaccine manufacturers in a bid to start production of the virus, said Josh Morrison, one of its founders.

More than a quarter of the volunteers are in Brazil, where the coronavirus is spreading fast.

Morrison said 1DaySooner has contacted vaccine developers planning final-stage studies there to suggest they consider people on its list for conventional studies, too.

Proponents note that the approach was used safely for diseases such as malaria, typhoid, cholera as well as the flu. Some experts are calling for a cautious approach.

Caution towards polio vaccine for Covid-19

Indian scientists have responded cautiously to a suggestion by global researchers that the oral polio vaccine be tested for Covid-19 treatment, saying it is a testable idea based on a sound scientific concept but may offer only limited protection against the infection.

With a vaccine for Covid-19 at least a year away, scientists say repurposing already safe and effective vaccines is the way to go for immediate relief against Covid-19.

The repurposed vaccines could include the oral polio vaccine (OPV) and the Bacillus CalmetteGuerin (BCG) used against tuberculosis, both part of the immunisation given to Indian children.

It is worth conducting a clinical trial, said Ram Vishwakarma, director of the CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM) in Jammu.

A study was published last week by an international team of researchers in the journal Science. The researchers, including Shyamasundaran Kottili and Robert Gallo from the University of Maryland School of Medicine in the US, said the OPV should be tested to see if it might protect people from the SARS-CoV-2 virus.

They noted that the vaccine used to prevent poliomyelitis infections has been around since the 1950s, and is found to provide some protection against other viral infections.

Hydroxychloroquine wont stop coronavirus deaths

WHOs top scientist has said its now been definitively proven that the cheap malaria drug hydroxychloroquine the drug favoured by President Donald Trump doesnt work in stopping deaths among people hospitalised with the new coronavirus.

But Dr Soumya Swaminathan said there could still be a role for the drug in preventing people from catching Covid-19 in the first place and noted that clinical trials testing hydroxychloroquines role in this are ongoing.

Swaminathan said in a press briefing on Thursday that there is still a gap in determining whether hydroxychloroquine has a role at all in the prevention or minimising the severity of the illness in early infection or even in preventing it.

The UN health agency announced this week that it is suspending the hydroxychloroquine arm of its own trial testing various experimental therapies for Covid-19, referring to previous results from a large UK trial and a separate analysis of the evidence on the drug.

The other drugs being tested by WHO, including treatments used in the past for Ebola and AIDS, are still being pursued.

(With agency inputs)

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From warning on dexamethasone to HCQ: Latest on Covid-19 treatment, vaccines - Hindustan Times

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Achilles Therapeutics doses first patient in Phase I/II Study in advanced non-small cell lung cancer – GlobeNewswire

Tuesday, June 23rd, 2020

Achilles Therapeutics doses first patient in Phase I/II Study in advanced non-small cell lung cancer

Stevenage, UK 23 June 2020 Achilles Therapeutics (Achilles), a clinical stage biopharmaceutical company developing personalised cancer immunotherapies, today announced that it has dosed the first patient in a Phase I/II CHIRON study of a clonal neoantigen T cell (cNeT) therapy in patients with advanced non-small cell lung cancer (NSCLC). In May 2020, Achilles dosed the first patient with cNeT in its Phase I/II THETIS study in recurrent or metastatic malignant melanoma.

Achilles precision tumour-infiltrating lymphocyte (TIL) therapy uses cutting edge genomics to selectively target patient specific clonal neoantigens targets which are believed to be present on all tumour cells this approach has the potential to transform the treatment of cancer.

The CHIRON study is an open-label, multi-centre Phase I/II trial evaluating the safety, tolerability and clinical activity of cNeT therapy as a single dose in adult patients with advanced metastatic NSCLC. The trial is expected to recruit approximately 40 patients and report interim data in the first half of 2021. Recruitment is ongoing across sites in the UK, with additional sites to open in the US and Europe. Link to Study.

The cNeT dosing of the first patient with NSCLC marks another important milestone for Achilles. Our opportunity to serve patients is tremendous as NSCLC remains one of the most prevalent and poorly served of the solid tumours, said Dr Iraj Ali, CEO of Achilles Therapeutics. As with our melanoma study, the CHIRON study is an entirely personalised cell therapy designed to be exquisitely specific and effective and has the potential to help us fundamentally change how certain cancers are treated.

We have been working closely with the Achilles team to design and set up this study across the UK, and are delighted to be dosing the first NSCLC patient with this innovative experimental cell therapy here at University College London Hospital (UCLH), the lead clinical site, said Dr Martin Forster, Associate Professor in Medical Oncology and Study Chief Investigator.

Achilles is developing personalised T cell therapies for solid tumours targeting clonal neoantigens: protein markers unique to each patient that are present on the surface of all cancer cells. Using its PELEUS bioinformatics platform, Achilles can identify clonal neoantigens from each patients unique tumour profile which are present on every cancer cell. Achilles uses its proprietary process to manufacture T cells (cNeT) which exquisitely target a specific set of clonal neoantigens in each patient. Targeting multiple clonal neoantigens that are present on all cancer cells, but not on healthy cells, reduces the risk that new mutations can induce immune evasion and therapeutic resistance, and allows individualised treatments to target and destroy tumours without harming healthy tissue.

- Ends -

Notes for Editors:

About Achilles Therapeutics

Achilles Therapeutics is a clinical stage, biopharmaceutical company developing personalised T cell therapies targeting clonal neoantigens: protein markers unique to the individual that are expressed on the surface of every cancer cell. The Company has two ongoing Phase I/II studies, the THETIS study in patients with recurrent or metastatic malignant melanoma and the CHIRON study in patients with advanced non-small cell lung cancer (NSCLC). Achilles uses DNA sequencing data from each patient, together with the proprietary PELEUS bioinformatics platform, to identify clonal neoantigens specific to that patient, and then develop personalised T cell-based therapies specifically targeting those clonal neoantigens.Achilles was founded in 2016 by lead investor Syncona Ltd and in September 2019 the Company raised 100M in an oversubscribed Series B financing led by RA Capital, cornerstoned by Syncona and joined by new investors including Forbion, Invus, Perceptive Advisors and Redmile Group. For further information please visit the Companys website at:www.achillestx.com

About Lung CancerLung cancer, which forms in the tissues of the lungs, usually within cells lining the air passages, is the leading cause of cancer death worldwide. Each year, more people die of lung cancer than die of colon, breast and prostate cancers combined. The two main types of lung cancer are non-small cell and small cell. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for about 85% of all cases. The five-year survival rate for patients diagnosed in the United States with any stage of lung cancer is estimated to be 18%.

About TRACERxThe TRACERx (TRAcking Cancer Evolution through therapy (Rx)) is a translational research study, led by Achilles founder, Professor Charles Swanton, aimed at transforming our understanding of cancer evolution and take a practical step towards an era of precision medicine.

Despite major advances in the understanding of cancer biology and the translation of these findings into novel therapeutics, the majority of patients with advanced melanoma fail to derive durable clinical benefit from existing standard-of-care therapies. Through integrative analysis of genomic and immunological landscapes, the TRACERx study seeks to address this. Tumour specimens and peripheral blood are studied in highly relevant contexts at multiple stages of a patients treatment journey, from potentially curative resections of locally-advanced disease, through to biopsies of lesions responding or refractory to systemic therapies in the setting of advanced disease.

Wherever possible, analyses will be performed in a longitudinal manner, allowing serial assessment of anti-tumour immunity, tumour-specific genomics and their interaction. Key objectives of the study include determination of spatial and temporal changes in immunological, genomic and transcriptomic landscapes, identification of novel molecular drivers, immunotherapeutic targets and assessment of the impact of cytotoxic, immune-modulatory and targeted therapies on both the tumour microenvironment and peripheral blood.

Further information:

Achilles TherapeuticsDr Iraj Ali Chief Executive Officer+44 (0)1438 906 906media@achillestx.com

Julia Wilson Head of Communications+44 (0)7818 430877j.wilson@achillestx.com

Consilium Strategic CommunicationsMary-Jane Elliott, Sukaina Virji, Melissa Gardiner+44 (0) 203 709 5000achillestx@consilium-comms.com

US Investor Relations - Solebury Trout Lee Stern +1 646-378-2922 lstern@troutgroup.com

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Achilles Therapeutics doses first patient in Phase I/II Study in advanced non-small cell lung cancer - GlobeNewswire

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Why a wellness routine is your top priority amid the pandemic and how to start – KSL.com

Tuesday, June 23rd, 2020

NEW YORK (CNN) As states gradually reopen even as the pandemic wears on, many of us are concerned about our health and well-being. Especially now, with some continuing to stay at home and social distance while others join the throngs at nationwide Black Lives Matter protests, it may even be a priority.

From state to state, the loosening of restrictions vary, and within our local communities, the reality is that not only do people have different ideas on what constitutes social distancing but for many others still, in the face of racial inequality, the desire to create social change far outweighs the potential risk of spreading or catching the virus.

It's all the more reason to make sure we're taking the best care of ourselves to fortify against the disease. But while living a healthy life may be a desired goal, how to achieve it is another story.

Even if you're someone whose healthful habits were perfected to a tee during pre-pandemic times, you may find yourself struggling to engage in even the most basic self-care in these increasingly unpredictable days.

That's where a wellness routine can come in handy.

I'm not talking about a spa escape every so often or even regular massages or chef-prepared meals (though all of that may sound really nice). I'm talking about creating your own personalized routine that will benefit you physically and emotionally, one that simply requires a regular commitment to yourself.

Creating a wellness routine allows you to shift from diet culture and adopt healthy habits that easily fit into your daily lifestyle. What's more, having a routine allows you to focus on health goals by creating structure and organization, which can be particularly beneficial when things seem out of your control, like life during an unprecedented pandemic and simultaneous upheaval as people fight against social injustice.

In fact, predictable routines, or ritualistic behavior "developed as a way to induce calm and manage stress caused by unpredictability and uncontrollability, heightening our belief that we are in control of a situation that is otherwise out of our hands," according to researchers at Tel Aviv University.

"We need an internal structure because our external lives have become totally unstructured and that triggers anxiety and stress," said Robin Foroutan, a New York City-based integrative medicine dietitian and spokesperson for the Academy of Nutrition and Dietetics.

"In the beginning, we thought this was going to be a little break; a couple of short weeks, and then we'd resume life as we knew it. Now we know that probably is not going to be the case. We don't know how long this will last, but we can find ways to stay steady and structured on the inside amidst the chaos outside."

Engaging in a wellness routine with a focus on good nutrition, exercise, sleep and stress management can boost our health and well-being and strengthen our immunity during a time when we may need it most.

And while social obligations, travel and other commitments typically make it challenging to start new habits, being stuck at home without these distractions provides an opportune time to start creating a wellness routine that is accessible, doesn't require a lot of money and is something that you can count on during this uncertain time and in the future, too.

Health experts say it's important to create a manageable routine that you can stick with as part of a lifestyle not something overly ambitious that you can't sustain. One way to do that is to start small and build upon it, as you feel comfortable.

Here are some tips to get started in creating your personal wellness routine.

"Most people feel better when they are going to bed and waking up at consistent times, eating regular meals and snacks and getting a steady dose of exercise, said Marysa Cardwell, a registered dietitian, nutrition therapist and certified personal trainer based in Salt Lake City, Utah.

For sleep: Everyone's sleep schedule is different, and that's OK, as long as you stick to your natural circadian rhythms, experts say. That means going to sleep when the sun is setting (or a bit later) and waking up when sun is rising (or a little later, according to your individual needs).

Aiming for seven to nine hours of sleep is key, as it helps to "reduce the stress hormone cortisol and your adrenal load," Cardwell said.

Getting adequate sleep also bodes well for engaging in other healthful behaviors by going to bed at a reasonable hour, you'll be less likely to engage in nighttime eating or mindless eating in front of the TV, and you're more likely to wake up early and start exercise, Cardwell explained.

For eating: Setting regular meal times, and taking a break to eat your food mindfully is key, Cardwell advised, but when you actually eat is up to you. "Some do well on three meals per day with an afternoon snack; others prefer three smaller meals and three snacks."

Regardless of the pattern you choose, aim to eat at least every four hours, which prevents blood sugar from crashing and can lead to overeating. For example, if you're eating three meals and one afternoon snack, you might choose to eat breakfast at 8 a.m., lunch at 12 p.m., a snack at 4 p.m. and dinner at 7 p.m.

Taking a few deep breaths, enjoying the wonderful smells of the food you are about to eat and chewing food really well can all help make mealtime a healthful ritual, Foroutan explained.

Additionally, dinnertime can become a daily social ritual by sharing the meal with family or friends, advised Jen Scheinman, a Denver-based registered dietitian nutritionist and owner of Jen Scheinman Nutrition, a virtual nutrition coaching practice. "Even a Zoom dinner with a friend if you're by yourself can help you feel connected."

For fitness: Pick a time that you're most likely to stick with. That might mean taking a morning walk before your day gets started, or scheduling your favorite fitness class on your calendar so you won't forget.

"I shut my day down with a run or yoga at around 5:30 p.m. That's my last thing for the day. The more you can make it a routine, the less you have to think about it," Scheinman said.

Planning what you will eat and how you will exercise means that you are more likely going to do what you intend to do, which will ultimately help you achieve your health goals. For example, planning meals in advance means you'll be less likely to reach for quick sugary snacks when you run out of energy. It also helps to limit shopping trips.

"Not only does planning your meals ahead of time help cut down on the number of times you're going to the grocery store, but it can also help reduce food waste and ensure you have meals that were intentionally picked to fit your nutritional goals," said Denver-based registered dietitian nutritionist Kelli McGrane.

For food: Eating a nutrient-rich breakfast sets the stage for making other healthful choices throughout the day.

Choose protein-rich breakfasts like egg whites, cottage cheese or smoked salmon on a bagel; Greek yogurt, smoothies with low-fat milk, high fiber cereals with milk or peanut butter on whole wheat toast.

Scheinman recommended preparing breakfast foods ahead of time, like making overnight oats with milk. "It makes the breakfast routine less daunting."

For lunch and dinner, Cardwell encouraged a fist-size portion of protein, such as fish, chicken or beans; a fistful of carbohydrates like whole wheat pasta or brown rice; and a half plate of veggies. This will help meet your micronutrient needs, as well as fiber. Use fats sparingly, as a condiment, to make your food taste better, but limit fried foods and saturated fat, Cardwell advised.

For snacks, choose protein and carb combos, like cheese with crackers, sliced fruit with peanut butter, nuts and seeds with dried fruit or Greek yogurt. Pairing protein with carbs "helps keep your blood sugar level stable, and helps you stay fuller longer," Cardwell said.

Scheinman recommended using the weekends for batch cooking, like making chili or soups, which you can freeze to enjoy later in the week. Washing and chopping veggies and fruit during the weekend can also save you time during the week.

For fitness: Pick a fitness activity that inspires you and is doable. There are a lot of fitness apps offering free trials and online Zoom fitness classes, so you can use this time as an opportunity to try something new. Cardwell recommended aiming for at least 30 minutes per day, if possible.

If you are looking for a simple at-home cardio workout, MaryAnn Browning, founder and CEO of Browningsfitness in New York, recommended jumping jacks, high knees, butt kicks, burpees and switch jumps during which you'll jump to turn 180 degrees and then back again for 15 seconds each. Then repeat the circuit five to 10 times, depending on what you can handle.

For at-home fitness essentials, Browning recommended getting a set of yellow, green and red resistance bands, which can be used for back, bicep, triceps, shoulders and leg work. She also recommended looped bands to go around the calves or thighs, which strengthen the glutes and can help prevent knee and back injuries.

If you want to weight train but don't have equipment, anything that will give you muscle tension will be beneficial, such as jugs of water, books or even your children. "I use my kids I'll do planks and have them sit on me ... or I'll do leg presses while letting them do airplane," Cardwell said.

And don't forget to keep moving throughout your day. Tracking apps like Lose It! are a good way to see how normal daily activities can all count toward our daily fitness goals.

"Dancing with your kids or partner, yard work, house projects, sex and cleaning are all trackable activities. Doing these activities with intention and extra vigor all count towards a healthy lifestyle," said Cardwell, who is also a contributing dietitian for Lose It!

For sleep: Engage in a bedtime routine where you can quiet down and prepare for sleep. "Turn off electronics, including the TV, iPad, and cell phones an hour before bedtime," Scheinman advised. This helps to reduce exposure to blue light, which "the brain perceives as daylight, so your brain is not quite getting the signal that it's nighttime and melatonin is not produced."

Unplugging also prevents you from checking one more email or scrolling through social media while in bed, which can be stimulating and interfere with sleep, Scheinman explained.

Most experts recommended engaging in a morning ritual that brings you pleasure. "Starting your day with the same routine each morning can bring steadiness and calm to the rest of the day. You are starting from a more grounded and positive place, versus waking up; grabbing the phone and checking the news and getting stressed out," Foroutan said.

"The morning is a nice time to start integrating things you didn't have time for previously like taking the dog for a longer walk in the morning, making a nice cup of coffee you can sit and enjoy or engaging in a meditation practice," Scheinman added.

"It sets the day off with a healthy intention, with a sense of comfort. ... I know this is what I do," Scheinman said.

Foroutan enjoys waking up and writing down three things she is grateful for. "Starting the day with a thought about gratitude can be really centering. Writing it down does something extra it solidifies the thought and intention. Not every day is good but there's something good in every day. Even if it's one small thing that gives you a sense of gratitude that's really grounding and it can help shift your perspective."

Stretching your body after you wake up or doing a sun salutation can help to get your blood flowing and your body moving in the morning.

It's also important to prioritize self-care. "Make stress relievers like enjoyable activities a non-negotiable right now," Cardwell said. That may include knitting, taking an extra-long shower or bath, reading, taking a tea break, enjoying a glass of wine or calling family members. Even better, schedule these stress relievers into your day just like mealtimes and other obligations.

"We're taking stock of what's important ... and (our) health is important. Doing these things now can help you deal with the stress of right now," Cardwell said.

It can also keep you healthy and feeling good well into the future, too. That's a gift from quarantine life if there ever is one.

The-CNN-Wire & 2018 Cable News Network, Inc., a Time Warner Company. All rights reserved.

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Integrative Medicine in Child Neurology: What Do Physicians Know and What Do They Want to Learn? – Physician’s Weekly

Tuesday, June 2nd, 2020

Pediatric neurology patients frequently use integrative medicine; however, providers may feel uncomfortable or unfamiliar with these therapies. Child neurologist attitudes toward integrative medicine and educational needs in integrative medicine have not been assessed. A national, anonymous survey was distributed to Child Neurology residents (n=294) and program directors (n=71) to assess attitudes toward specific integrative medicine modalities, practices in discussing integrative medicine with patients, and perceived need for a curriculum on integrative medicine; 61 (17%) partially and 53 (15%) fully completed the survey. Comparative analyses applied chi-square and independent tests. Qualitative content analysis was performed on free text responses. Most providers surveyed consider mind and body practices safe (93% of respondents) and effective (84%), but have concerns about the safety of chiropractic manipulation (56% felt this was harmful), and the efficacy of homeopathy (none considered this effective). Few inquire about patient integrative medicine use regularly. Child Neurology residents are interested in further education on this topic.

PubMed

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Create a "healing" home with lighting, color and plants – AZFamily

Tuesday, June 2nd, 2020

Creating a healthy, healing environment for our family is so important as we navigate the stress and anxiety of this time. 75% of the immune system is the result of environmental and lifestyle factors. Top Immune Health Expert, Board Certified Integrative MD Dr. Taz, shares easy ways to create a healing home by reducing toxicity and activating our senses.

HOW TO CREATE A HEALING HOME with Dr. Taz

1) Lighting: Create ambient, soft light with lots of natural light to help enhance mood and lower cortisol. Replace fluorescent bubs, led bulbs. Consider sun lamps. Natural light is the most beneficial to the body.

2) Color: Color can be healing and color influences our feelings. White color on walls, dcor and furniture leads to a feel of clean and serenity. Teal accents in a room or overall color scheme of a house are associated with purity, relaxation and calmness. If someone needs to benefit from being in a relaxing envornment considere adding teal to the room. Red embodies power, vitality, energy. Rooms that need to be productive can utilize having red incorporated into their dcor. Magenta provides emotional balance and Yellow gives off a sense cheerfulness. Depending on the room and purpose, consider color to make the most out of the space.

3) Air: Household plants reduce indoor air pollution. My favorite house plants include: Peace Lily, Ferns, Aloe, Snake Plants, and Lemongrass. All plants have different needs for growth so make sure when choose a plant it is in a place and environment where it thrives. Plants also give us a way to feel closer to nature and be connected to mother earth.

Dr. Taz Bhatia, M.D. is a board-certified integrative medicine physician and wellness expert, who gained national recognition as a best-selling author of the books, What Doctors Eat, The 21 Day Belly Fix, and Super Woman RX. Her integration of Eastern medical wisdom with modern science, along with her unique Power Type discovery, has led to featured segments on The Today Show, Dr. Oz, Live with Kelly & Ryan and eventually the premiere of own PBS special Super Woman RX with Dr. Taz.

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Meditation initiative benefits healthcare workers – CapeGazette.com

Tuesday, June 2nd, 2020

The Heal the Healers Now project of Delmarva is part of a nationwide initiative to bring the stress-reducing Transcendental Meditation technique to doctors, nurses and medical providers who are battling the coronavirus pandemic.

Kim Bemis, head of the Transcendental Meditation program for Delmarva, said, "The TM program is an effortless, enjoyable, and easy-to-learn mental technique for deep relaxation and stress reduction. It has been successfully offered in hospitals and clinics as well as medical schools, academic and VA medical centers, military academies, substance abuse centers, prisons and other settings."

Most recently, the program was offered at Weill Cornell Medical Center-New York Presbyterian Hospital with significant reductions in physician burnout, insomnia and symptoms of post-traumatic stress.

Bemis said, "Even before the pandemic, a Harvard report cited physician burnout as a public health crisis that urgently demands action. And today, the situation is far worse. This highly effective program can help our healthcare providers during this devastating public health crisis."

Laurie Vonasek, RN, MSN, an adjunct professor at Wesley College, said, "Practicing the Transcendental Meditation technique twice daily for the past three years has been transformative. I have increased focus, quieted my mind, decreased anxiety, slept better, increased efficiency, and I am slower to react to negative stimulus. I think before I react. TM has decreased the effects of stress. I am healthier and happier. I could not navigate life, especially now with all the uncertainty and pain related to COVID-19 without meditating. It has helped me to achieve balance and peace. Nurses by nature care for others before they care for themselves. It is time to help nurses heal.

Dr. Uday Jani, a doctor of integrative medicine in Lewes, said, The power of meditation to activate the bodys capacity for self-healing by reducing levels of stress-related hormones and strengthening the immune system has been well documented over the years. We are fortunate to be able to learn from master meditation teacher Kim Bemis, who draws on two decades of studying and living in the Himalayas to teach this remarkably effective technique in our community.

For more information on learning the Transcendental Meditation program, or to donate to help make this program available to medical providers who need it, go to http://www.healthehealersnow.org or contact KimBemis@tm.org.

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Benefits, Safety, and Adjunct Modality Prevalences of Long-Term Botuli | JPR – Dove Medical Press

Tuesday, June 2nd, 2020

Dion Diep,1 Jasmine Ko,2 John Lan,3 Kinga T Koprowicz,3 Gordon Ko3,4

1MD Program, University of Toronto, Toronto, ON, Canada; 2Department of Kinesiology, McMaster University, Hamilton, ON, Canada; 3Canadian Centre of Integrative Medicine, Toronto, ON, Canada; 4Division of Physical Medicine & Rehabilitation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Correspondence: Gordon KoClinical Adjunct Lecturer, Division of Physical Medicine & Rehabilitation, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON M4N 3M5, CanadaTel +1416-480-4342Fax +1416-480-6885Email drgordko@rogers.com

Introduction: There is a paucity of long-term treatment benefit and safety data of botulinum toxin A (BTX-A) for cervical dystonia (CD) and myofascial neck pain syndrome (MPS). Additionally, the prevalence of adjunct modality uses during this period is unknown despite evolving practices.Objective: To assess and compare treatment benefit, safety, and adjunct modality prevalences of long-term BTX-A injections between CD and MPS patients.Design: Retrospective cohort study.Setting: Private practice tertiary care clinics in Toronto.Patients: Convenience sample of 37 (52.9%) CD and 33 (47.1%) MPS patients treated for a meanSD duration of 7.2 4.3 and 8.3 4.7 years, respectively.Interventions: BTX-A injections administered at least once yearly, for a duration longer than 1 year.Main Outcome Measures: Toronto Western Spasmodic Torticollis Rating Scales (TWSTRS) for disability and pain, Patient Global Impression of Change (PGIC) score, time to peak effect, duration of total response, adverse effects, and prevalence of adjunct modalities.Results: CD patients experienced improvements in TWSTRS disability (17.57 6.79 to 9.81 4.35, p< 0.001) and pain (14.61 3.08 to 9.05 3.49, p< 0.001) scores as well as PGIC score (52.00% 23.60% to 64.80% 23.60%, p=0.007). MPS patients experienced improvements in TWSTRS disability (15.86 7.70 to 10.07 7.01, p=0.01) and pain (15.25 4.09 to 10.85 4.49, p=0.01) scores. In both cohorts, there were no changes in time to peak effect and duration of total response. Adverse effects were minimal and self-limiting. Prevalences of adjunct modalities used by CD versus MPS patients were 28.13% versus 50.00% for anesthetic procedures, 23.08% versus 15.38% for image-guidance, 65.71% versus 56.25% for pectoralis minor injections, and 47.06% versus 53.13% for cannabis-use.Conclusion: There were demonstrated and comparable treatment benefit, safety, and adjunct modality prevalences. Our study is the first to demonstrate that long-term BTX-A injections for MPS, although commonly used off-label, can be effective and safe.

Keywords: botulinum toxin, cervical dystonia, myofascial pain syndrome

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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So Sleep Wrinkles Are A Thing: Here’s What It Says About Your Skin – mindbodygreen.com

Tuesday, June 2nd, 2020

Sleep wrinkles arent your average fine lines: While expression lines can form overtime from repeatedly moving your face, these wrinkles form exclusively from your sleeping positionsay, if you curl up on your side or sleep on your stomach, face smashed into the pillow. Thats why one study on facial aging identified a distinct set of wrinkles that form from sleep alone, which brings us to the anecdotally dubbed sleep wrinkles.

It makes sense, no? If you sleep with your face smashed into the pillow for eight or some hours each night, thats quite a long time for the delicate skin on your face to endure that pressure. Not only that, but theskin is more permeable at night, which means it is more vulnerable to transepidermal water loss (also why you might opt for a heavier night cream to seal in moisture; nighttime skin care is no joke). This means your skin is not only experiencing friction, but may dry out faster, too. All things considered, of course you may wake up to some folds across your skin.

Now, those indents tend to fade when youre young, as your plump skin is chock-full of collagen and can quite literally bounce back from the pressure. (Think of a firm mattress molding to your weight as you sleep, then filling out once you leave your cozy bed.) But as you grow older and your collagen levels start to decline, you may notice those lines stick around well after mid-morning.

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Two Potential Treatments for COVID-19 Unfold in the Hudson Valley – Chronogram

Tuesday, June 2nd, 2020

State by state, America is reopening after sheltering in place and we're doing it on a wing and a prayeror at least, with a face mask and rubber gloves. Only a few protections stand between us and a virus so menacing, it actually has spikes. Even more than disinfectant wipes and hand washing, we need good science to fight COVID-19. A safe, widely available vaccine could take months to roll out, as cells in a petri dish can only grow so fast. That's why scientists are carrying out parallel efforts to explore more rapid-fire solutions. Around the globe and close to home, doctors and researchers are uncovering every stonefrom repurposing existing drugs to developing antibody treatments and exploring nutraceuticals that could offer safe, affordable protection naturally. The following two research endeavors hold promise, and they're unfolding right here in our local communities.

When his 48-year-old mother struggled to recover from COVID-19 in late March, James Bruzzese, a second-year medical student at CUNY School of Medicine in Harlem, knew where to turn. He called his mentor, Dr. Richard Horowitz, a board-certified internist with a private integrative medicine practice in Hyde Park. Considered among the country's top Lyme disease doctors, Horowitz has built a practice around combining classical and complementary treatments for tick-borne infections. Not everyone jibes with Horowitz's stylesome online patient reviews bristle with talk of long waitlists and steep la carte expenses for his services. But after he became instrumental in helping Bruzzese's younger sister, Julia, in her battle with Lyme, Bruzzese grew close to the doctor. "He's been letting me shadow him, so every time I get a little break from school, I do that," says the 23-year-old Brooklynite. "I've been exposed to a lot in his practice and it's been an amazing experience."

Bruzzese's mother, Josephine, had woken up on the morning of March 22 with severe symptoms in line with COVID-19fever, body aches, coughing, and such severe shortness of breath that she couldn't get up from bed. "It was scary from the start," recalls her son. His family called New York's coronavirus hotline, which advised getting her to an emergency room. When her ambulance pulled in at NYU Langone Hospital in Sunset Park, Brooklyn, the ER was eerily empty. The hospital had no coronavirus tests at the time, but a lung X-ray showed that Josephine had severe lobe pneumonia and she was clinically (if not serologically) diagnosed with COVID-19 on the spot. Yet the doctors declined to admit herinstead, they gave her a dose of Zithromax (azithromycin) and sent her home with four more days of the oral antibiotic. Bruzzese was shocked. "We learn as medical students that the treatment for pneumonia is IV antibiotics," he says. "They didn't even do a culture. On my board exams, if I were to answer a question about a patient presenting with pneumonia and I didn't say, 'Order a culture to see what type of bacteria it is and [administer] IV antibiotics,' I would get that question wrong. What was going on during this crisis, just giving people a very weak oral antibiotic for a severe pneumonia, was just crazy."

Bruzzese knew his mother needed more. Back home, the family happened to have Plaquenil (hydroxychloroquine) on hand because of his sister, but they didn't want to administer it blindly. He reached out to a local doctor for guidance who advised him on dosing, and Josephine remained on Zithromax and Plaquenil for about 10 days. Her fever and body aches went away, but the respiratory symptoms lingered. "She was still coughing like crazy and couldn't breathe," Bruzzese recalls. That's what prompted him to reach out to Horowitz for help. "I called him in desperation, and I gave him the rundown like I would do on rounds." (Current FDA guidelines caution against the use of hydroxychloroquine for COVID-19 treatment outside of the hospital setting.)

As it turned out, Horowitz had recently treated another COVID-19 patient successfully with a simple, natural therapyglutathione. Produced in the liver and also available to take as a nutritional supplement, glutathione is one of the body's main antioxidants. It assists with detoxification and helps to combat free radicals, the molecules that can damage cells when there is too much inflammation in the body. "He said, 'If you're willing, let's see if it helps your mom, too,'" recalls Bruzzese, who happened to have glutathione in the family medicine cabinet. Horowitz suggested a 2,000-milligram dose, and within an hour Josephine was breathing easier and even got out of bed to take a shower. The next morning, she took a double dose and felt even better, and in the following days she made a full recovery. "We saw these miraculous effects very quickly," says Bruzzese, "and Dr. Horowitz said, 'We need to write this up. This is definitely something.'" With Bruzzese as a coauthor, Horowitz went on to publish a study of the two patients in the online journal Respiratory Medicine Case Reports in May.

"It is a miracle and it's not," says Horowitz of glutathione, which he has used on thousands of patients in his medical practice over the past 30 years. "It's already in the literaturethere are published articles on glutathione showing that it has anti-viral activity against herpes viruses, HIV, and hepatitis. The problem is, all of the COVID research is happening through pharmaceutical companies. No one is looking at natural approaches. You hear a little about how low vitamin D might put you at risk, so it's coming out in dribs and drabs." And just like with vitamin D, you can be deficient in glutathioneespecially if you've been exposed to a lot of environmental toxins (which is everyone). Older people are also more likely to be depleted of the compound.

Horowitz's a-ha moment with glutathione came from reading dozens of scientific articles about COVID-19. "I saw that the inflammatory molecules that are released when people are exposed to COVID are exactly the same inflammatory molecules that are released when you're exposed to Lyme," he says. "There's a cytokine storm that happens, which is like a fire in the body, a huge inflammatory reaction that can affect all the organs. And we know that with COVID, it's not the virus itself that's killing people. It's this overstimulated immune response with all the inflammation. When I saw that the cytokines in COVID were the same molecules in Lyme, I thought, well, we already know how to lower these cytokines." (Cytokines are molecular messengers between cells. Inflammatory cytokines are molecular messengers that can increase the inflammatory response.)

On a biochemical level, the way to reduce this inflammation is to turn off a switch inside the nucleus of the cells called NF-kappa-B. Three different compounds effectively shut down these inflammatory cytokines: glutathione itself; N-acetylcysteine (NAC), which is the precursor of glutathione; and alpha lipoic acid, which helps to regenerate glutathione. Horowitz recommends taking all three as supplements600 mg of NAC two to three times a day; 600 mg of alpha lipoic acid once or twice a day (the higher dose can cause reactive hypoglycemia in sensitive individuals); and 250 to 500 mg of glutathione twice a dayas a preventive measure against COVID-19. People who have multiple chemical sensitivities or a sulfa allergy should be careful using glutathione, as it could cause an allergic reaction (Dr. Horowitz has seen this only rarely in IV forms of glutathione). The oral version is generally safe for everyone, but it is always best to check with your healthcare provider before starting a new regimen.

The next step is to conduct a randomized controlled study of glutathione for COVID-19, but Horowitz will need help to make that happen. One way would be to give the therapy to residents at a nursing home at high risk and see how well it protects them compared to residents of a nursing home that doesn't use it. He reached out about a glutathione study to his contacts in government after serving on a committee that gave recommendations on tick-borne diseases to Congressand got back only two responses. "The medical journals are excited about remdesivir, an antiviral that only lowers your course in the hospital by four days," he says. "I'm sorry, but we're not going to base our hopes on getting four days less in the hospital. We really need something that's going to protect the public now, that is cheap, safe, and effective. Based on the peer-reviewed literature, and my clinical experience, there is a high likelihood that it will be NAC, alpha lipoic acid, and glutathione."

The upshot: The evidence on glutathione for COVID-19 is anecdotal and we need a solid study to explore its potential.

If anyone knows the importance of controlled clinical trials, it's the folks at Regeneron, a local biotech company that has seven FDA-approved medicines and about 20 investigational drugs in the pipeline. Headquartered in Tarrytown, with manufacturing facilities near Albany and in Ireland, Regeneron is buzzing with COVID-19-related activity these days. "This is a once-in-a-career thing for many people," says Alexandra Bowie, Regeneron's senior director of corporate communications, about her colleagues' opportunity to help find a cure for the biggest health crisis of our time. "The company has really rallied around this and made it our main priority, while still ensuring that we're able to deliver the medicines we make and give to people every day. We're shifting a lot of our R&D resources, our clinical resources, to prioritize the COVID projects." While the endgame is to develop a vaccine, that's not in Regeneron's wheelhouse, but they are going full force on two projects that harness their expertise. One looks to repurpose an existing medicationthe FDA-approved rheumatoid arthritis drug Kevzarawhile the other is a novel antibody therapy that could serve as a bridge of protection before a vaccine is widely available.

Jointly developed by Regeneron and the French pharmaceutical firm Sanofi, Kevzara (sarilumab) is an injectable medication that inhibits the pathway of an inflammatory cytokine called interleukin-6 (IL-6). "Some data came out of China indicating that IL-6 medicines may be helpful in addressing some of the [hyperactive] inflammatory response that comes at late stages of COVID-19," says Bowie. However, that data came from a 21-patient trial without a placebo group for comparison. So, Regeneron and Sanofi quickly launched a larger, double-blind trial to investigate the drug further. The results from phase 2 of the trial, which was conducted in both severe and critical hospitalized COVID-19 patients, did not show much effect on the severe patientsthough it did show a positive trend in the critical patients at high doses. The next step will be to focus only on critical patients in phase 3 of the trial. "We'll see what goes on there," says Bowie, "but this really confirms how important it is to conduct trials with rigor, and with a placebo arm."

Regeneron is more optimistic about its work creating a novel antibody treatment for COVID-19. The idea is that if you can find an antibody, or combination of antibodies, that can block the spike protein on the SARS-CoV-2 virus (coronavirus) cell, then you are effectively disarming it, because the virus uses its spikes to infect into healthy cells. To find these virus-neutralizing antibodies, Regeneron uses its VelociSuite platform, which is an antibody discovery development technology. "Essentially, we've replaced portions of a mouse's immune system with a human immune system, with genes that code for human immune response," explains Bowie. "When these mice are challenged with a virus or a bacteria, they produce antibodies, which are protective proteins, that look just like human antibodies. We then comb through those antibodies and pick the ones that are the most potent at blocking the virus." (If this sounds very Frankenstein, it is, especially to anyone interested in animal rights. Unfortunately, the FDA requires animal testing for most new medicines, though Regeneron says it adheres closely to the industry's ethical laws related to animal welfare.)

Moving quickly, Regeneron has already created a cocktail of two antibodies, and the treatment will go into clinical trials in humans in June. They chalk up their speed to their prior experience developing similar antibody cocktail treatments against Ebola as well as against Middle Eastern Respiratory Syndrome (MERS), which is another type of coronavirus.

It's important to note that an antibody treatment differs from a vaccine in a number of ways. While a vaccine "teaches" the body how to make antibodies that protect against a pathogen, an antibody treatment skips that step and simply administers the necessary antibodies directly into people. Unlike a vaccine, which can protect you for years or even a lifetime, an antibody treatment is effective for only a month or so. But it could offer stop-gap protection, especially for high-risk groups like healthcare providers, who could be re-dosed as needed. More important, an antibody treatment could also help treat people who are already infected, effectively curing the virus. "That's why we think that our option is really a bridge to a vaccine," says Bowie. "We're still going to need a vaccine in the longer term, but this can be a good solution for the next year or however long we need it."

The upshot: Kevzara might help treat critical COVID-19 patients, but Regeneron's antibody treatment is the one to watch as we await results from the clinical trials. Stay tuned.

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Knowing Signs and Symptoms of Lyme Disease Is Critical for Early Detection and Treatment, Says Industry-Leading Quidel – Yahoo Finance

Tuesday, June 2nd, 2020

With America on lockdown the past two months, many people turned to the woods for safe isolation and social distancing. And now as sections of the country reopen and summer approaches, the outdoors will be filled with hikers, campers, hunters and fishermen. It will also be filled with ticks that may be carrying the bacterial infection that spreads Lyme disease to humans and pets.

Unlike a mosquito bite where people know immediately if they have been bitten, a tick bite may go undetected; and one of the challenges with Lyme disease is that symptoms may not appear for two to six weeks. That makes it critically important to take steps to avoid catching the disease and to know its warning signs so treatment can begin early when it is most effective.

"While not all deer ticks cause Lyme disease, it is still smart to avoid areas where deer ticks live, especially wooded, bushy areas with long grass," said Sean McCloy, M.D., a family medicine physician with an expertise in Lyme disease at the Integrative Health Center of Maine. "You can decrease your risk of getting Lyme disease with some simple precautions, such as wearing shoes, long pants tucked into your socks, a long-sleeved shirt, a hat and gloves. And after spending time in vulnerable areas you should always check your clothing, yourself, your children and your pets for ticks; and remove any that you find as soon as possible with tweezers. Only a minority of tick bites leads to Lyme disease; but the longer the tick remains attached to your skin, the greater your risk of getting the disease."

For those who are bitten by an infected tick, early warning signs include fever, headache, fatigue, joint pain, swollen lymph nodes, weakness in the limbs and a characteristic skin rash often in a bull's-eye pattern. If untreated, new symptoms could include neurological problems and, though less common, heart problems (such as an irregular heartbeat), eye inflammation, liver inflammation and severe fatigue.

"If you think you've been bitten and have signs and symptoms of Lyme diseaseparticularly if you live in an area where Lyme disease is prevalentit is critical to get tested as treatment is more effective if begun early," said Robert Dracker, M.D., chairman of the heart, lung and cancer committee for the Medical Society of New York and medical director of Summerwood Pediatrics and Infusacare Medical Services in New York. "Fortunately, new tests are available that are easy to administer and provide results faster than ever."

Leading the way in Lyme disease testing is the innovative Sofia 2 Lyme FIA test. This in-office test provides a patient as well as his or her physician with indicative results within minutes as opposed to days, which has historically been the norm. Performed in the privacy of a doctors office or local clinic, it is also the only test that can get results from a simple finger prick of blood. The test was developed by Quidel, a California-based diagnostic healthcare manufacturer and one of the nations leaders in developing rapid diagnostic health solutions.

"Given that the vast majority of patients tested are negative, getting results quickly will mean discernable peace of mind and remove a significant weight off a persons shoulders," said Dr. Dracker. "Not having to wait days for test results allows physicians and nurse practitioners to more rapidly treat those patients with positive results while more quickly pursuing other diagnosis and treatment for those who test negative."

Patients seeking more information are encouraged to contact their private physician to find out more about the availability of this innovative new test in their area. More information on Quidel may be obtained at quidel.com.

About Quidel Corporation

Quidel Corporation serves to enhance the health and well-being of people around the globe through the development of diagnostic solutions that can lead to improved patient outcomes and provide economic benefits to the healthcare system. Quidels products aid in the detection and diagnosis of many critical diseases and conditions including not only Lyme disease but, among others, influenza, respiratory syncytial virus, strep A, herpes, pregnancy, thyroid disease and fecal occult blood. Quidels research and development engine is also developing a continuum of diagnostic solutions from advanced immunoassay to molecular diagnostic tests to further improve the quality of healthcare in physicians offices and hospital and reference laboratories. For more information about Quidel, visit quidel.com.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200602005149/en/

Contacts

Jim Yeager424-644-0225 (office)818-264-6812 (mobile)jim@breakwhitelight.com

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beautiful and minimalist design that helps us breathe and relax – Explica

Tuesday, June 2nd, 2020

Calmaria means calm in Portuguese, and is the word chosen by Fabio Sasso to launch his first application. Sassos name may not sound too much to you, but its a designer who currently works for Google and he is the founder of Abduzeedo: a prestigious blog design that we have already talked about on other occasions.

In the midst of a global pandemic and seeing racial unrest increase in the United States, one could feel somewhat anxious. There are many breathing techniques to relax, and Calmaria invites us to try a well-known one.

Obviously, coming from the hand of Abduzeedo, design is one of its most striking points. A kind of minimalist sunset, with warm tones, will indicate the way in which we must breathe.

Although there are many websites and applications that use this method, the truth is that a nice and easy to follow interface It can help us establish a habit or that we feel like using it throughout the day.

Calm is based on the 4-7-8 technique, a method designed by Dr. Andrew Weil (director of Integrative Medicine at the University of Arizona and a popular character in the United States).

As the name suggests, this technique is made up of three steps different: inhale for four seconds, hold your breath for seven seconds and exhale for eight seconds.

It has a web app and an Android version (the iOS version will be soon)

We will not have to be counting time, since this app will indicate the missing seconds in each phase at all times. Currently it has a web app and an Android version, and they assure that soon the iOS version will arrive. Another positive point is that its completely free.

ShareAbduzeedo launches its first app: beautiful and minimalist design that helps us breathe and relax

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iCAD Hosts Virtual Roundtable Event on Breast Cancer Surgery and Targeted Radiation During COVID-19 – Yahoo Finance

Tuesday, June 2nd, 2020

Leading breast cancer specialists to share best practices on leveraging the latest in cancer therapies to enhance patient care and minimize virus exposure

NASHUA, N.H., June 01, 2020 (GLOBE NEWSWIRE) -- iCAD, Inc. (ICAD), a global medical technology leader providing innovative cancer detection and therapy solutions, today announced it will host a free virtual roundtable event for clinicians, titled The Impact of COVID-19 on Breast Cancer Surgery and Targeted Radiation Therapy, on June 4, 2020 at 7 pm ET/4 pm PT. Event registration is available via this link: https://register.gotowebinar.com/register/5960832272590383888.

The roundtable will feature leading specialists in breast cancer treatment, including the following experts*:

The COVID-19 pandemic has introduced unprecedented challenges to our health care system and specifically impacted cancer screenings and treatment in our country and worldwide. During these extraordinary times, it is imperative for clinicians to share best practices and adapt approaches to patient care. iCAD is honored to host virtual events such as this, which provide an educational forum for clinicians to enhance patient care during this global healthcare crisis and beyond, according to Stacey Stevens, President of iCAD. In the face of this pandemic, iCADs technology is now more relevant than ever. Intraoperative radiation therapy (IORT) with the Xoft Axxent Electronic Brachytherapy (eBx) System offers a viable solution that could potentially alleviate the burden to our health system, while enabling clinicians to administer high-quality care to patients who are candidates, while minimizing their potential exposure to the novel coronavirus.

Xoft breast IORT is a single-fraction therapy option that allows select early-stage breast cancer patients to replace weeks of daily radiation with one treatment, delivered at the time of surgery. This targeted treatment option offers a full course of radiation in just one day, which could contribute to a reduction in the healthcare system resources needed for breast cancer patients during the COVID-19 pandemic and reduce those patients risk of exposure to the novel coronavirus by minimizing the number of visits required to a hospital or medical facility.

In the recent months during the COVID-19 pandemic, hospital resources have become limited in many areas, and guidelines issued by a number of medical societies advise clinicians to determine how best to triage the care of cancer patients safely.1 Some breast cancer patients are choosing to delay parts of their treatment for safety concerns, according to Sadia Khan, DO, FACS, Assistant Clinical Professor of Surgery at Keck School of Medicine, USC, Director of Integrative Breast Oncology at Hoag Breast Program. In areas where there is still a high incidence of COVID-19, some patients with breast cancer may opt to choose IORT, which offers a one-dose radiation option for patients who meet the criteria. For those who are candidates, IORT gives patients an additional option to complete their radiation in a one-time dose, which decreases their exposure to the hospital.

Positive results from a long-term study involving Xoft breast IORT conducted at Hoag Memorial Hospital Presbyterian were published in the Annals of Surgical Oncology in 2019.2 Led by Melvin J. Silverstein, MD, Medical Director of the Hoag Breast Center, the prospective study, titled Intraoperative Radiation Therapy (IORT): A Series of 1000 Tumors, found breast cancer recurrence rates of patients who were treated with Xoft breast IORT were comparable to those seen in the cornerstone, randomized TARGIT-A and ELIOT trials, which evaluated IORT using different technology.

A number of breast cancer patients at our facility have had their treatment delayed due to the COVID-19 pandemic. This is concerning to physicians and patients alike, as some cases could potentially progress and it could result in a considerable backlog of patients who require urgent treatment with more advanced disease, according to Michael Howard, PhD, DABMP, RSO, Director of Oncology Services, Chief of Medical Physics, Sarah Cannon Cancer Institute, Parkridge Medical Center, HCA Healthcare. The concern for a second wave of COVID is very real, but IORT offers a way to help reduce this potential backlog.

Story continues

The reality is, IORT may be able to play a bigger role right now in the treatment of patients. In some cases, it may be ultimately more beneficial to offer IORT to avoid the backlog in treatment as a means of not overrunning hospitals and radiation centers once we are back up and running, added Barry Rosen, MD, FACS, Chief of Breast Surgery, Advocate Healthcare and Managing Partner, TME. IORT is one of those exceptional interventions that I believe satisfies the triple aim in treatment: it offers benefits to patients, providers and payers alike. For patients, it offers added convenience, with better cosmetic outcomes and fewer side effects; from a physician standpoint there is an inherent efficiency, as it enables them to condense one month of daily treatments to a single dose of targeted radiation. Lastly, for payers, the overall cost of treatment is reduced as the course of treatment may be reduced from weeks of daily fractions to one concentrated dose of radiation, administered at the time of surgery.

As clinicians, we are going to have to adapt to the COVID-19 situation as it evolves. At a certain point, delaying treatment for even early-stage breast cancer is going to come with risk. In many cases, the decision really should be made to go forward with cancer treatment; IORT offers a treatment option that may allow more women to get the treatment they need during this time, according to Charles Wesley Hodge, MD, Radiation Oncologist, Florida Hospital Celebration Health/AdventHealth. We are facing an unprecedented challenge in healthcare, and as clinicians we need to come together and adjust to these new realities. For those of us who practice in the oncology space, it is particularly challenging because we are dealing with a potentially life-threatening illness that requires appropriate management. Now is the time for clinicians to work together, to adjust to our new reality, and to come up with an approach that will do the greatest good for our patients.

This virtual roundtable event is a part of larger series of webinars hosted by iCAD in recent weeks, featuring leading experts in breast cancer detection and treatment. This series has examined various aspects of breast cancer care in the era of COVID-19, including risk adaptive tools and pragmatic solutions for both screening and treatment. To view the schedule, register for an upcoming free event, or view a prior event on-demand, visit https://www.icadmed.com/educational-webinars.html.

*Panelists have been compensated with an honoraria/speaking fee, but are encouraged to provide their own expert opinions and viewpoints. Dr. Patel is a member of iCADs Board of Directors.

About iCAD, Inc.

Headquartered in Nashua, NH, iCAD is a global medical technology leader providing innovative cancer detection and therapy solutions.

ProFound AI is a high-performing workflow solution for 2D and 3D mammography, or digital breast tomosynthesis (DBT), featuring the latest in deep-learning artificial intelligence. In 2018, ProFound AI for Digital Breast Tomosynthesis (DBT) became the first artificial intelligence (AI) software for DBT to be FDA-cleared; it was also CE marked and Health Canada licensed that same year. It offers clinically proven time-savings benefits to radiologists, including a reduction of reading time by 52.7 percent, thereby halving the amount of time it takes radiologists to read 3D mammography datasets. Additionally, ProFound AI for DBT improved radiologist sensitivity by 8 percent and reduced unnecessary patient recall rates by 7.2 percent.1

The Xoft System is FDA-cleared, CE marked and licensed in a growing number of countries for the treatment of cancer anywhere in the body. It uses a proprietary miniaturized x-ray source to deliver a precise, concentrated dose of radiation directly to the tumor site, while minimizing risk of damage to healthy tissue in nearby areas of the body.

For more information, visitwww.icadmed.com and http://www.xoftinc.com.

Forward-Looking Statements

Certain statements contained in this News Release constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements about the future prospects for the Companys technology platforms and products. Such forward-looking statements involve a number of known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of the Company to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Such factors include, but are not limited, to the Companys ability to achieve business and strategic objectives, the ability of IORT to alleviate the burden to our health system and minimize a patients potential exposure to Covid-19, to be more beneficial for patients that traditional therapy or to be accepted by patients or clinicians, the impact of supply and manufacturing constraints or difficulties, uncertainty of future sales levels, to defend itself in litigation matters, protection of patents and other proprietary rights, the impact of supply and manufacturing constraints or difficulties, product market acceptance, possible technological obsolescence of products, increased competition, litigation and/or government regulation, changes in Medicare or other reimbursement policies, risks relating to our existing and future debt obligations, competitive factors, the effects of a decline in the economy or markets served by the Company; and other risks detailed in the Companys filings with the Securities and Exchange Commission. The words believe, demonstrate, intend, expect, estimate, will, continue, anticipate, likely, seek, and similar expressions identify forward-looking statements. Readers are cautioned not to place undue reliance on those forward-looking statements, which speak only as of the date the statement was made. The Company is under no obligation to provide any updates to any information contained in this release. For additional disclosure regarding these and other risks faced by iCAD, please see the disclosure contained in our public filings with the Securities and Exchange Commission, available on the Investors section of our website athttp://www.icadmed.comand on the SECs website athttp://www.sec.gov.

Contacts:Media inquiries:Jessica Burns, iCAD+1-201-423-4492jburns@icadmed.com

Investor Relations:Jeremy Feffer, LifeSci Advisors+1-212-915-2568jeremy@lifesciadvisors.com

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How to breathe using the 4-7-8 technique if you’re feeling anxious – SBS

Tuesday, June 2nd, 2020

At some point, youve probably been told totake a deep breathin a moment of anxiety. As it turns out, theres more to the clich than you might think. We spoke to experts about 4-7-8 breathing, a technique that, in a matter of seconds, can ease your negative response to stress. Inspired by yoga, 4-7-8 breathingisnt just a psychological tool: It can actually change the speed at which your heart beats and promote the effective pumping of blood to various organs and muscles. Heres how (and why) to do it.

Its a breathing pattern based on pranayama, which is the part of yoga that deals with breath control. 4-7-8 is relaxing because it extends the exhale portion of the breathing, said Dr. Victoria Maizes, the executive director of the Andrew Weil Center for Integrative Medicine at the University of Arizona. Extending the exhale has a quieting effect on the body by interacting with the parasympathetic nervous system (essentially the flip side of the fight-or-flight stress response).

Its free,its simple, and you can choose to use it any time youre feeling stressed.

Sit upright with your chest open and put the tip of your tongue at the roof of your mouth. Theres a little ridge behind your upper front teeth where your tongue will stay for the entire exercise (the placement of which will cause a whoosh sound when you exhale). Inhale through your nose to the count of four, hold your breath for seven counts, and exhale slowly through your mouth for eight counts (you can purse your lips while exhaling if that feels more comfortable for you).

This is one breath, so do this three more times for a total of four breaths. If its helpful, you can count on your fingers to track how many cycles youve done. You have to exhale slowly or else youll run out of air pretty fast, since your exhale is now twice as long as your inhale, says Maizes. The ratio is whats important not the exact time you spend on each phase so you can speed the whole thing up or slow it down as long as you keep the 4-7-8 count intact.

I think its hard to learn anything new when youre really anxious, but in particular, I think its hard to learn to relax, says Maizes, which is why she suggests making 4-7-8 a practice by doing it twice a day, every day. You can do it more than twice a day do it 20 times a day if you want but you should only do the 4-7-8 breath four times in a row at a time. Once you get really good at it after practicing it for about a month or longer the typical recommendation is to bump it up from four to eight times in a row, but no more. (Its not exactly clear why this restriction exists, but Maizes theorises that its because you can blow off more carbon dioxide while slowly exhaling, and doing too much of that could make you lightheaded or uncomfortable.)

Because youre doing no more than four cycles (or, eventually, eight) at a time, the exercise will only take seconds. It is physiologically impossible to be stressed and relaxed at the same time, Maizes said. Practicing 4-7-8 breathing makes your nervous system smarter, so then if youre anxious, your body goes, Oh yeah, I know how to relax. Ive been practicing this for weeks. Sometimes, Maizes adds,if youre feeling really anxious, you might have difficulty both taking a deep breath and holding your breath. Thats why its helpful to familiarise yourself with the practice throughout the day, particularly in moments when you are not feeling stressed. The more you practice it and get better at it, the more helpful it will be for you when youre feeling a lot of anxiety, says Dr. Sarah Kate McGowan, assistant clinical professor in the department of psychiatry and behavioural sciences at the David Geffen School of Medicine at UCLA. Thats not to say that you shouldnt try 4-7-8 in the moment if youve never done it before it will likely still be helpful but ina highly anxious moment, its easier to draw on something youve done before.

Its free,its simple, and you can choose to use it any time youre feeling stressed. Part of anxiety is loss of control, says McGowan. With something like 4-7-8, you dont need to rely on anyone but yourself. Dont underestimate the self-efficacy aspect of this practice.

But there are physiological components at play, too. This sort of breathing helps regulate the bodys stress response the fight or flight reaction that helps us survive life-threatening situations. In stressful circumstances, your breath increases in order to get extra oxygen to your lungs and your brain helpful, should you actually have to fight or take flight. But in a lot of modern day stressors, there isnt a physical threatcreating that anxiety.So what were doing with breathing exercises is trying to slow down our bodys sympathetic response, McGowan said.

The bodys stress response isnt inherently a bad thing. Even fruit flies have a stress response, said Dr. Esther Sternberg, research director at the Andrew Weil Center for Integrative Medicine. You cannot live without it. The goal is not to get rid of the stress response thats not possible. The question is how you turn that negative stress into good stress and make it work for you.

And the way to do that is by engaging whats called the relaxation response. This response isactivated by the vagus nerve, which connects the spinal cord to the internal organs of the body. One way to quickly engage the vagus nerve in other words, to quickly engage the relaxation response is through deep breathing. Its like putting your foot on the brake and putting the brake on the stress response, Sternberg says.

Breathing deeply changes the speed at which your heart beats.

Breathing deeply changes the speed at which your heart beats. If you look at one minute of heart rate, youll see that your heart doesnt beat exactly evenly. This is whats called heart rate variability, which is the variation in the spaces between the beats. Thats because the vagus nerve is directly connected to the part of the heart that controls heart rate, the rhythm center, says Sternberg. When you inhale the heart rate increases, and when you exhale, it decreases. As you breathe deeply, it changes the speed at which the heart beats, so you get more variability. The greater the heart rate variability, the more effective the pumping of the blood to all your different organs and muscles.

Just as there are brain pathways engaged with negative experiences of stress, Sternberg says positive experiences such as deep breathing, walking in nature, and even prayer engage other brain pathways that are rich in endorphins and feel-good molecules. In addition to making you feel good, they contribute to putting that break on the stress response, Sternberg says. Remember,if youre feeling anxious, your body is telling you something. she says. As soon as you change course, you shift from feeling stressed to feeling exhilarated the difference between the two feelings is whether or not youre in control.

This article originally appeared on Science of Us 2020 All Rights Reserved. Distributed by Tribune Content

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Quick and Cheap: RT-Lamp COVID-19 tests to cost up to Rs 200, give results in less than an hour, says CSIR – Times Now

Tuesday, June 2nd, 2020

Quick and Cheap: RT-Lamp COVID-19 tests to cost up to Rs 200, give results in less than an hour, says CSIR  |  Photo Credit: iStock Images

New Delhi [India], May 27 (ANI): The Council for Scientific and Industrial Research (CSIR) has signed an MoU with Reliance to develop a new RT-LAMP COVID-19 diagnostic kit, which is cheap and gives a quick result, said Director-General Dr Shekhar C Mande on Wednesday.

COVID-19 RT-LAMP (Reverse Transcriptase-Loop Mediated Isothermal Amplification) test is a nucleic acid-based test carried out from nasal or throat swab samples from the patients. The test has been developed and successfully demonstrated using synthetic templates.

Talking about the test, Dr Mande said that "RT-LAMP test is cheap because you don't need to have instrument cost. It's also quite quick. You can actually take it into different areas. You can very quickly take it into the rural area."

The CSIR on Tuesday had announced that the Institute of Integrative Medicine in Jammu has tied up with Reliance Industries Ltd to develop and scale-up a new RT-LAMP based COVID-19 diagnostic kit.

Dr Mande said that the new testing kit "could cost between Rs 100 and Rs 200. It will take less than an hour for a test to do. Within one hour, we can get the result."

Talking about the difference between Feluda test and RT-LAMP kit, Dr Mande said: "Technological basis of Feluda kit and RT-LAMP kit is different. Faluda is based on technique call crisper cash, while RT-LAMP is based on RT-PCR. There is isothermal PCR. So, the technology of both kits is different."

"RT PCR requires a specialised machine. The first step is a reverse transcription that is common to both RT-PCR as well as RT-LAMP. The second step is once DNA is made from RNA, the PCR quantitative to PCR machine does three cycles of temperature," added he.

The CSIR-DG said further said: "In this condition, you do something at 92 degrees; you do something at 55 degrees; you do something at 73 degrees, and you keep cycling between these three temperatures about 25 and 30 times, and in each cycle the number of DNA molecules doubles and you measure. That is in the fluorescent level. So that is a base of RT-PCR."

"But RT-PCR required this machine the fluorescent level is costly and it takes time. On the other hand, the RT-LAMP test is using only four to six primers for the amplification of DNA. It uses four and six primers and you do the amplification of DNA. First of all, it is common for converting RNA into DNA. When in the second step, you use only a single temperature something like 60-degree Celsius," he added.

Dr Mande informed that the Institute of Integrative Medicine in Jammu and Reliance Industries Ltd have agreed that they will scale up the production of the test kit.

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Swarms of locust still active in 15 districts of Rajasthan, Madhya Pradesh – Free Press Journal

Tuesday, June 2nd, 2020

In the times when India is grappling due to the COVID-19 situation, swarms of locust attacking various parts of the country is another formidable challege the country has to tackle. According to the Agriculture Ministry, nearly 15 districts in Rajasthan and Madhya Pradesh have experienced locust attacks which are still active.

The Ministry of Agriculture and Farmers Welfare on Wednesday informed that locust control operations have been stepped up in affected states to combat the menace.

"Amidst a wave of locust swarms sweeping across western & northwestern India, Department of Agriculture & Farmers' Welfare has stepped up locust control operations in affected states of Rajasthan, Punjab, Gujarat & Madhya Pradesh," said the Agriculture Ministry in a press release.

The ministry further added: "As of today, there are active swarms of immature locust in Barmer, Jodhpur, Nagaur, Bikaner, Ganganagar, Hanumangarh, Sikar, Jaipur Districts in Rajasthan and Satna, Gwalior, Seedhi, Rajgarh, Baitul, Devas, Agar Malwa district of Madhya Pradesh."

The ministry further informed that till 26 May, control operations against locusts done in 47,308-hectare area at 303 places in Rajasthan, Punjab, Gujarat, and Madhya Pradesh by Locust Circle Offices (LCO) in coordination with District Administration and State Agriculture Department.

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Southern Company Gas donates $1 million to Morehouse School of Medicine to support the advancement of health equity – Yahoo Finance

Wednesday, May 27th, 2020

This contribution is a part of the $50 million commitment from Southern Company and its subsidiaries to historically black colleges and universities

ATLANTA, May 26, 2020 /PRNewswire/ --Southern Company Gas and the Southern Company Gas Charitable Foundation are donating $1 million toward academic expansion and efforts to provide greater equity in healthcare led by Morehouse School of Medicine (MSM).

Southern Company Gas Logo (PRNewsfoto/Southern Company Gas)

This gift, part of MSM's Expansion into the Future Initiative, enables the medical school to strengthen its academic offerings and research enterprise, including its budding Natural Products Research Center and the development of an Emerging Pathogens Research Team focusing on topics such as coronaviruses.

"As our communities continue to be impacted by the coronavirus and work to recover from what has become a global health crisis, Southern Company Gas recognizes the immediate need to support institutions seeking solutions while addressing critical health equity issues," said Kim Greene, chairman, president and CEO of Southern Company Gas. "We support MSM's cutting-edge research and education model, which fosters greater inclusion in not only healthcare, but ultimately our entire society."

According to a study led by amfAR and the Center for Vaccine Innovation and Access and data from the U.S. Census Bureau, black Americans represent 13.4% of the U.S. population, but counties with higher black populations account for more than half of all COVID-19 cases and almost 60% of deaths. MSM's efforts to improve diversity in the medical profession, research into health challenges facing minority communities and service to underserved communities play a critical role in addressing racial inequality.

The academic expansion initiative will provide the campus community with state-of-the-art facilities that effectively integrate technology and foster collaborative learning among students, faculty, and staff. It will also support MSM's research portfolio focused on infectious diseases such as COVID-19, as well as cancer, cardiovascular disease and neuroscience, among other topics critical to improving the health of underserved communities.

"Our existing virology research's success may help to establish an even larger U.S and global structure examining emerging pathogens of all types and how we can identify and address them," says Professor Vincent C. Bond, chair of the Department of Microbiology, Biochemistry, and Immunology at MSM. "Our integrative approach to health care allows us to translate the discoveries made in labs, to the bedside of patients, and then to the communities we serve."

Recently celebrating its 45th anniversary, MSM has made monumental strides increasing the class size of each of its degree-granting programs, including the Medical program, Graduate Education in Biomedical Sciences, Graduate Education in Public Health and Physician Assistant Studies.

Higher education plays a critical role in driving economic wellbeing; however, studies have shown one approach to ending the cycle of poverty caused by our nation's long history of racial inequity considers quality education and healthcare. This is why earlier this year Southern Company Gas and its parent company, Southern Company, announced plans to donate $50 million to historically black universities and colleges to support career readiness and develop future leaders.

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For more information on Southern Company Gas' efforts to support COVID-19 relief, visit scgcares.org.

About Southern Company GasSouthern Company Gas is a wholly owned subsidiary of Atlanta-based Southern Company (NYSE:SO), America's premier energy company. Southern Company Gas serves approximately 4.2 million natural gas utility customers through its regulated distribution companies in four states and approximately 700,000 retail customers through its companies that market natural gas. Other nonutility businesses include investments in interstate pipelines, asset management for natural gas wholesale customers and ownership and operation of natural gas storage facilities. For more information, visit southerncompanygas.com.

About the Southern Company Charitable Gas FoundationThe Southern Company Gas Charitable Foundation is a 501(c)(3) nonprofit committed to supporting those who are transforming lives by tackling complex challenges with revolutionary vision. Every year, the Charitable Foundation donates millions of dollars in grants to organizations that align with Southern Company Gas' values and that passionately work to improve the lives of the communities the company serves. As an independent, nonprofit philanthropic foundation, the Southern Company Gas Charitable Foundation is funded solely by Southern Company Gas through shareholder dollars.

About Morehouse School of MedicineMorehouse School of Medicine (MSM), located in Atlanta, GA exist to improve the health and well-being of individuals and communities, increase the diversity of the health professional and scientific workforce, and address primary health care through programs in education, research, and service, with emphasis on people of color and the underserved urban and rural populations in Georgia, the nation,and the world. MSM is among the nation's leading educators of primary care physicians and has twice been recognized as the top institution among U.S. medical schools for its dedication to the social mission of education. The faculty and alumni are noted in their fields for excellence in teaching, research, and public policy, and are known in the community for exceptional, culturally appropriate patient care. Morehouse School of Medicine is accredited by the Commission on Colleges of the Southern Association of Colleges and Schools to award doctorate and master's degrees.

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SOURCE Southern Company Gas

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COVID-19 here to stay till 2021, aggressive testing needed to curb its spread: Health experts – ETHealthworld.com

Wednesday, May 27th, 2020

Global health experts on Wednesday said novel coronavirus is here to stay for more than a year and called for aggressive testing to prevent its spread. In an interaction with Congress leader Rahul Gandhi, health experts Professor Ashish Jha and Professor Johan Giesecke talked about the COVID-19 pandemic as part of the series being aired on Congress social media channels.

While Jha exuded confidence that a vaccine will be available in a year's time, Prof Giesecke said India should practice a lockdown that is as 'soft' as possible, as a severe lockdown will ruin its economy very quickly.

"When the economy is opened up after lockdown, you have to create confidence among people," Harvard health expert Ashish Jha told Gandhi.

Jha is a professor of Global Health at TH Chan School of Public Health and Director, Harvard Global Health institute. He said coronavirus is a '12-18 months' problem and the world is not going to be free of this till 2021.

Professor Johan Giesecke, former chief scientist, European Centre for Disease Prevention and Control said India should have a 'soft lockdown'. "The situation that India is in, I think, you should have a soft lockdown, as soft as possible," he said. "I think for India, you will ruin your economy very quickly if you have a severe lockdown. It is better, skip the lockdown, take care of the old and the frail...," he noted.

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Clinical trials are showing that Remdesivir can be life-saving drug for COVID-19 infected patients – Firstpost

Wednesday, May 27th, 2020

Press Trust of IndiaMay 26, 2020 08:04:50 IST

With a vaccine still a long distance away, efforts to repurpose old medications used for other ailments provide hope of an early counter to COVID-19, say, scientists, placing the antiviral remdesivir on top of the list of possible contenders.

As COVID-19 continues its spread crossing 5.2 million cases and 3,38,000 fatalities on Saturday several categories of drugs are under clinical trial. Of them, remdesivir, which initially went into trials for treating the deadly Ebola virus five years ago, has shown promise by modestly speeding recovery from COVID-19, experts said.

More than 130 drugs are under experimentation to treat COVID-19, some may have the potential to stop the virus while others may help calm overactive immune responses that damage organs, according to a tracker maintained by the Milken Institute, an independent economic think tank in the US,

Remdesivir is helping people recover faster, and is lowering the death rate among critically ill patients.

"Right now, there is only one effective approach which is to repurpose already approved drugs for other diseases if they can be used for COVID-19. One example is remdesivir," Ram Vishwakarma, director of the Indian Institute of Integrative Medicine, CSIR, Jammu, told PTI.

Remdesivir is helping people recover faster, and is lowering the death rate among critically ill patients, Vishwakarma said, adding that it can be life-saving.

We do not have time to develop new drugs. New drug development takes five-10 years so we are using existing drugs and conducting clinical trials to find if any of them are effective, Vishwakarma said.

Some molecules available for treating diseases like HIV or other viral infections can be quickly checked against the novel coronavirus, he explained. If found effective, they can be used against COVID-19 with the appropriate approval from drug control bodies.

When drug company Gilead Sciences sought to begin clinical trials for remdesivir to treat the novel coronavirus, it immediately got approval from the US FDA.

According to Vishwakarma, the other drug showing promise is favipiravir, a broad-spectrum antiviral approved in Japan, which is also under clinical trials for its effectiveness against COVID-19.

The Indian Institute of Chemical Technology (IICT), Hyderabad, has developed the technology to make favipiravir, Council of Scientific and Industrial Research (CSIR) Director-General Shekar Mande announced this month.

CSIR is conducting clinical trials for favipiravir, remdesivir and an anti-inflammatory drug called colchicine, which is commonly used to treat gout, said Vishwakarma.

"A number of drug trials are happening in India, which we are doing with pharmaceutical companies," Vishwakarma said.

Of the drugs under trial, remdesivir has shown the most promising results, agreed Subhabrata Sen, professor at the Department of Chemistry in Shiv Nadar University in Uttar Pradesh.

Sen, whose lab is involved in the discovery of biologically active molecules, told PTI that some of the drugs being tested are antivirals, and some are antimalarials and antibiotics.

Of the antivirals in the tracker list, some are new molecules under trial, whereas others are old drugs being repurposed and tested for their effectiveness against COVID-19.

Remdesivir, according to a study published in the New England Journal of Medicine in April, mimics the genetic material of the coronavirus. When the virus copies its RNA or genetic material, the drug replaces some of the pathogen's building blocks.

According to the authors of this study, the drug prevents new virus copies from being produced.

Preliminary results had shown that patients who received remdesivir had a 31 per cent faster time to recovery than those who received placebo.

However, another study published in the journal Lancet in April cautioned that interpretation of these findings is limited since the remdesivir study was stopped early after the scientists were unable to recruit enough patients due to the steep decline in cases in China.

The authors of The Lancet study concluded that more evidence from ongoing clinical trials is needed to better understand whether remdesivir can provide meaningful clinical benefit.

Some drugs developed to treat HIV, such as lopinavir and ritonavir, are also being tested to cure COVID-19, Vishwakarma said.

A study published in Lancet this month said a treatment involving a combination of the drugs interferon beta-1b, plus the antiviral combination lopinavir-ritonavir and ribavirin, is better at reducing the viral load or quantity of the virus than lopinavir-ritonavir alone.

But these, too, were early findings, observed only in patients with mild to moderate illness, so the scientists behind the study stressed the need for larger trials to examine the effectiveness of this triple combination in critically ill patients.

Another study published last month in the journal Science noted the effectiveness of two small molecule drug candidates named 11a and 11b which could block the SARS-CoV-2 M protease enzyme, which the virus uses to make copies of itself.

The molecules could stop the virus from replicating in monkey cells and have been found safe for administration in rats and beagles, with the study concluding that both the drugs warrant further studies.

Scientists have also tested the effectiveness of therapies involving the use of antibodies that can bind to some parts of the virus, and block their entry into host cells.

In a study, published last month in the journal Cell, scientists reported that antibodies derived from the immune system of the South American mammal called llamas can block the entry of the novel coronavirus into host cells.

This study found that llamas, which belong to the same category of mammals as camels, produce special kinds of antibody molecules that bind tightly to a key protein on the novel coronavirus.

However, scientists believe its efficacy is yet to be proved in human clinical trials.

Last week, scientists from the Beijing Advanced Innovation Center for Genomics at Peking University in China, revealed a new method to identify multiple antibodies from recovered COVID-19 patients.

Using a single-cell genomics method, the researchers could rapidly identify antibodies from convalescent plasma, a component of patients' blood.

When the researchers tested these antibodies in mice, they found that some of them could neutralise the virus.

Another team from the University of Washington in the US found recently that a combination of antibodies, including those from a patient who had recovered from the 2002-03 SARS pandemic virus infection, can effectively block the novel coronavirus.

One of these molecules, named S309, showed particularly strong neutralising activity against SARS-CoV-2, they said, adding that it can act in combination with another, a less potent antibody that targets a different site on the virus.

However, these results to are yet to be validated in human clinical trials.

Among other therapeutics currently under trial or in use, Sen said US President Donald Trump's "game-changer" drug hydroxychloroquine was promising "until it demonstrated serious side effects in the form of cardiovascular complications", rendering it ineffective.

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Thought Technology’s Webinar Series Focuses on Adjunctive Therapies That Combine Well with Biofeedback and Neurofeedback – PR Web

Wednesday, May 27th, 2020

Dr. Donald Moss

MONTREAL (PRWEB) May 26, 2020

In an ongoing webinar series presented by Thought Technology Ltd., experts from various fields discuss how they are using biofeedback in their practices. Todays mental health practitioners have many tools at their disposal to best address the individual needs of their clients. In an upcoming webinar, Dr. Donald Moss will discuss adjunctive therapies that can be used in conjunction with biofeedback.

Adjunctive therapies are interventions that combine well with biofeedback and neurofeedback training and augment the therapeutic effect of the biofeedback and neurofeedback. The combined therapeutic effect of biofeedback and relaxation together is often greater than the effect of either intervention alone. Regular home practice of relaxation skills improves basal autonomic nervous system regulation and reduces the onset of problematic symptoms. This Webinar introduces six adjunctive therapies, including progressive muscle relaxation, autogenic training, paced diaphragmatic breathing, guided imagery, meditation, and mindfulness. Two of them will be demonstrated, and brief clinical vignettes will illustrate the use of the adjunctive techniques. Each of these skill sets can be administered on its own, with therapeutic effect, or provided in combination with biofeedback as a treatment package.

Adjunctive Therapies for Use with Biofeedback and NeurofeedbackPresenter: Dr. Donald MossDate: May 29, 2020Time: 1:00-2:00 pm EDT

Click here to register.

About Dr. Donald MossDonald Moss, Ph.D., BCB, is Dean, College of Integrative Medicine and Health Sciences, at Saybrook University, Oakland, CA. Dr. Moss is the Education Chair of the Society for Clinical and Experimental Hypnosis (SCEH). He is also the ethics chair and international certification chair for the Biofeedback Certification International Alliance. He has served as president of Division 30 (hypnosis) of the American Psychological Association, SCEH, and the Association for Applied Psychophysiology and Biofeedback (AAPB). Dr. Moss has a book with co-author Angele McGrady on Integrative Pathways: Navigating Chronic Illness with a Mind-Body-Spirit Approach (Springer, 2018), and a book with co-editor Fredric Shaffer on Physiological Recording Technology and Applications in Biofeedback and Neurofeedback (AAPB, 2019). He has a book in press with co-editor Inna Khazan on Mindfulness, Compassion, and Biofeedback Practice (AAPB). Moss is co-editor of Foundations of Heart Rate Variability Biofeedback (AAPB, 2016), co-author of Pathways to Illness, Pathways to Health (Springer, 2013), and chief editor of Handbook of Mind-Body Medicine for Primary Care (Sage, 2003) and Humanistic and Transpersonal Psychology (Greenwood, 1998).

About Thought Technology Ltd.Founded in 1975, Thought Technology is the world's leading biofeedback and physiological instrument manufacturer. Its products are used as an essential part of many therapeutic treatments and clinical assessment protocols in over 85 countries and are used by tens of thousands of clinicians in thousands of medical institutions.

Always supportive of new research and development ideas, Thought Technology Ltd. has encouraged a number of special interest groups and clinicians to create cutting edge applications for its instrumentation. Thought Technology Ltd. equipment is now being used in telemedicine, web-based monitoring and biofeedback, sports training, research in human-machine interface, physiology-driven multimedia environments and virtual reality. Constantly striving to improve the quality of the products and services, TTL has obtained, and maintains, ISO 13485, and CE certification for the organization and products.

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