StemCell Therapy

Stem cell therapy, also known as regenerative medicine, has been around for decades, but in recent years, the use of and interest in stem cell therapy has increased exponentially. The dramatic utilization of stem cell therapy, and the increasing government spend related to these novel techniques, have now caught the eye of federal regulators and prosecutors. In this client alert, we profile some brief context of stem cell therapy, the governments regulations governing these techniques, and some of the best practices for those interested in this emerging space.

Stem cells are cells from which all other cells with specialized functions are generated (i.e., the bodys raw materials). Stem cells may duplicate themselves to create more stem cells or they may generate cells with a specific function like blood or brain cells.

Stem cell therapy is used to repair or replace damaged tissue or cells within the body. Many in the medical community are hopeful that stem cell therapy can be used to treat a wide array of conditions and diseases from multiple sclerosis to vision loss to traumatic spinal cord injuries to Lou Gehrigs disease just to name a few.

The Food and Drug Administration (FDA) oversees and regulates stem cell therapy treatments. While the FDA has acknowledged that stem cell therapy has the potential to treat diseases or conditions for which few treatments exist, there are still only a few treatments that have actually been approved by the FDA. Many treatments are still only in early investigatory stages.

The FDA has recognized the massive potential that stem cell therapy has in allowing patients treatments for various conditions. Consequently, in 2017, the FDA issued guidance indicating its intent to exercise enforcement discretion as a means to support and expedite the development of regenerative medicine products. This enforcement discretion period was to allow innovators time to determine whether to submit an Investigational New Drug (IND) or marketing application and, if such an application is needed, to prepare and submit the application as appropriate. The FDA, however, has made clear its enforcement discretion policy only applies to products that do not raise potential significant safety concerns. What the FDA considers significant is debatable, creating uncertainty and ambiguity for those who might be relying on the FDAs enforcement discretion period.

Initially, the FDA stated that its enforcement discretion period would last through November 2020. But in July 2020, the FDA extended its enforcement discretion period through May 2021 a fast-arriving date. It remains unclear whether the FDA intends to extend the time period of its enforcement discretion any further, but either way, stem cell therapy providers would be well-served by planning for and expecting enforcement efforts to ramp up in the near future.

In 2019, the FDA went to great lengths to warn consumers of the potential fraud that may arise from what it called stem cell therapy hype, and encouraged consumers to make sure any stem cell therapy treatments were either approved or being studied as an IND. The FDAs concerns have led to multiple enforcement actions, including one just last month. On February 1, 2021, for example, the government announced the indictment of Ashton Derges, a healthcare provider in Missouri, who marketed stem cell shots as a successful treatment for various conditions, including COVID-19. According to the indictment, Derges was paid nearly $200,000 by patients for the stem cell shots, none of which actually contained stem cells at all. While this alleged fraud was not particularly sophisticated, it nonetheless marked a significant development: the governments first criminal prosecution of those touting stem cell therapies.

But blatant fraud is not the only type of stem cell therapy case the government has expressed interest in investigating. A primary concern of the government is the marketing and use of unproven stem cell treatments as miracle cures. A good case study of the risks associated with aggressive marketing of stem cell therapy is a case out of Florida involving US Stem Cell Clinic Inc. The clinic was marketing stem cell therapy to treat conditions and diseases such as Parkinsons disease, stroke, and brain injuries none of which were approved by the FDA. And, much of the marketing that US Stem Cell Clinic used promised almost miraculous results. As a result, last year, the FDA successfully permanently enjoined the US Stem Cell Clinic from selling or providing those stem cell therapy treatments. Notably, this case was pursued by the FDA despite the FDA explicitly stating its intent to be lenient with emerging stem cell therapy treatments.

Stem cell therapy is a groundbreaking medical tool with great possibilities to treat a plethora of diseases and conditions. As the industry continues to expand, so will the governments interest. Our firm continues to see an uptick in cases involving stem cell therapy treatments. And we have successfully assisted clients in avoiding unnecessary scrutiny by the FDA and other government regulators.

If you are in the stem cell therapy industry or are considering offering stem cell therapy treatments, we recommend that you:

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The Governments Watchful Eye on Fraud Stemming from Stem Cell Therapy - JD Supra

Dublin, April 01, 2021 (GLOBE NEWSWIRE) -- The "Automated and Closed Cell Therapy Processing Systems Market By Cell Processing Steps, Scale of Operations, End Users and Geographical Regions: Industry Trends and Global Forecasts, 2020 - 2030" report has been added to ResearchAndMarkets.com's offering.

The "Automated and Closed Cell Therapy Processing Systems Market: Focus on Apheresis, Expansion, Harvest, Fill/Finish, Cryopreservation, Thawing, 2020-2030" report features an extensive study of the current market landscape and future opportunities associated with the automated and closed cell therapy processing systems. The study also features a detailed analysis of key drivers and trends related to this evolving domain.

One of the key objectives of the report was to estimate the existing market size and the future growth potential of the automated and closed cell therapy processing systems. Based on various parameters, such as number of cell therapies under development, expected pricing, likely adoption rates, and potential cost saving opportunities from different automated and closed cell processing systems, we have developed informed estimates of the evolution of the market, over the period 2020-2030.

Advanced therapy medicinal products (ATMPs), such as cell therapies and gene therapies, have revolutionized the healthcare sector. Over the past two decades, more than 30 ATMPs have been approved. Moreover, according to a recent report (published by The Alliance for Regenerative Medicine), over 1,050 clinical trials are currently being conducted by over 1,000 companies, worldwide, focused on the evaluation of cell and gene therapies.

However, despite the numerous advances in this field, there are certain challenges that need to be addressed in order to achieve commercial success. For instance, the current cell therapy manufacturing process is labor-intensive, time consuming and costly. Further, the production of most of these specialized therapeutic products requires manual labor and are typically carried out discretely (open processing), thereby, rendering the processes difficult to scale-up, with high risk of contamination.

Another concern faced by cell and gene therapy manufacturers is batch-to-batch variability, given that even a minor change in the production protocol can affect the quality of the resulting product. Consequently, cell therapies are exorbitantly priced, ranging from USD 300,000 to USD 500,000 per dose.

Experts believe that some of the existing challenges related to cell therapy manufacturing can be addressed through the adoption of automated and closed cell processing systems. These solutions have been demonstrated to be capable of enabling stakeholders to manage various aspects of the cell therapy manufacturing process efficiently, while complying to global regulatory standards. Other benefits of such systems include reduced risk of contamination, optimum utilization of facility and resources, limited in-process variation and consistent product quality.

Further, the use of such automated systems enable significant reductions (in the range of 40% to 90%) in labor costs. In recent years, the cost saving potential of these systems, coupled to their ability to streamline and simplify the complex cell therapy processing (from initial cell collection till final formulation), has effectively captured the interest of several stakeholders engaged in this domain. Given the growing demand for cost-effective, personalized medicine, coupled to the benefits of automated and closed systems, we believe that this niche market is poised to witness significant growth in the foreseen future.

Scope of the Report

An insightful product competitiveness analysis, taking into consideration various relevant parameters, such as supplier power (based on the experience/expertise of the developer in this industry) and portfolio-related parameters, such as number of systems offered, cells supported, type of culture supported, scale of operation, applications, end users, support services offered, regulatory certifications/accreditations obtained and key product specifications.

Elaborate profiles of industry players that are currently offering automated and closed cell therapy processing systems, featuring an overview of the company, its financial information (if available), and a detailed description of the system(s) they offer. Each profile also includes a list of recent developments, highlighting the key achievements, partnership activity, and the likely strategies that may be adopted by these players to fuel growth, in the foreseen future.

An analysis of the various partnerships pertaining to automated and closed cell therapy processing systems, which have been established since 2016, based on several parameters, such as year of partnership, type of partnership model adopted, type of therapy, type of cell processing step, key automated and closed cell processing systems, partner's focus area, most active players (in terms of number of partnerships signed), and geographical location of collaborators.

A detailed assessment of the current market landscape, featuring an elaborate list of over 60 automated and closed systems, along with information on the cell therapy processing step for which they are designed (apheresis, separation, expansion, harvest, fill/finish, cryopreservation and thawing), their key features (traceability, user-friendliness, configurability and scalability, process monitoring, touch-screen user interface, data management, integration with other systems and alert system), product specifications (length, width, depth, height and weight), type of cells supported (stem cells and immune cells), type of cell culture (adherent and suspension), scale of operation (pre-clinical, clinical and commercial), application (research and therapeutic), end users (hospitals/medical centers/clinics, research institutes/academic institutes, laboratories, commercial organizations), key support services offered (product support, technical support, training, installation, qualification/validation, maintenance, regulatory support and others) and regulatory certification/accreditations obtained (GMP/cGMP, GAMP, GCP, GTP/cGTP, IEC standards, ISO standards, 21 CFR Part 11 and other).

The report features detailed transcripts of interviews held with the following industry stakeholders:

Key Questions Answered

Companies Mentioned

For more information about this report visit https://www.researchandmarkets.com/r/ly01kj

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Global Automated and Closed Cell Therapy Processing Systems Market Trends and Forecasts, 2020-2030: Cell Processing Steps, Scale of Operations, End...

WILLOWBROOK, Ill., March 31, 2021 /PRNewswire/ --Based in Willowbrook, Illinois, Russell Health, a national marketer and distributor of specialty medical products and services,was recently announced as one of The Silicon Review's "50 Leading Companies of the Year 2021."The feature strategically places the Russell Health brand alongside other tech innovators in industries including marketing, finance, software, sustainability, leadership and health. Russell Health's Profile features a Q&A with the leading tech publication covering the history of the Russell Health brand, services offered, anticipated trends in Stem Cell Recruitment Therapy, continued product category research, and more. Read the full feature here.

About Russell Health: Russell Health and its partners have distributed regenerative therapy products nationwide and achieved profound clinical outcomes in multiple therapeutic areas including cosmetics, wound care, pain management, podiatry, orthopedic, optometry and gynecology.

With their partners and suppliers, they work to provide innovative life-changing and sustaining products and therapies to patients and healthcare providers around the world.

Stem Cell Recruitment Therapy products take advantage of the body's ability to repair itself. Responsibly sourced acellular tissue allografts are helping people of all ages to recover from injuries and get their life back.

Quote about the current landscape and anticipated trends in Stem Cell Recruitment Therapy:

"We do not distribute 'Stem Cells' or 'Stem Cell Procedures'. All our products are acellular and do not contain live stem cells. By using a combination of growth factors and other endogenously synthesized molecules, Stem Cell Recruitment Therapyproducts help to assist the body with repair, reconstruction and supplementation of the recipient's tissue, as mentioned above. During the pandemic, we have seen a lot of patients and physicians searching for alternative treatments like ours that are safe and effective without posing any additional risks of infection while providing the clinic."(Ryan Salvino, CEO of Russell Health)

Quote about Russell Health's involvement in Stem Cell Recruitment Therapy research:

"We are currently working with some of the top leaders in the regenerative medicine field to continue to grow and provide new innovative products to our customers and their patients. We are always looking for new breakthrough products in the market to stay abreast on the new technologies and innovations in the field. We are consistently documenting patient results to provide clinicians with testimonialson how effective the Stem Cell Recruitment Therapy products are and how they are positively affecting patients' lives." (Jonathan Benstent, Vice President of Russell Health)

Visit Russell Health online to learn more about Stem Cell Recruitment Therapy. For media inquiries or to contact the Russell Health team directly, please visit http://www.russellhealth.comor email [emailprotected].

Contact: Veronica BennettPhone: 844-249-6200Email: [emailprotected]Mailing Address: 621 Plainfield Rd., Willowbrook, IL 60527Online: http://www.russellhealth.comSocial Media: http://www.linkedin.com/company/russell-health/

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Russell Health Highlighted in the Silicon Review's '50 Leading Companies of the Year 2021' - PRNewswire

By Pat Anson, PNN Editor

A California stem cell company has announced positive results from a small, early-stage clinical trial of an experimental stem cell therapy for knee osteoarthritis.

The Phase 1/2a trial conducted by Personalized Stem Cells (PSC) involved 39 patients with knee osteoarthritis who were given a single injection of autologous mesenchymal stem cells derived from their own body fat. Safety was the primary objective of the trial and there were no serious adverse events reported by the company.

The secondary objective of the trial was to assess the effectiveness of the therapy with the Knee Injury and Osteoarthritis Outcome Score (KOOS), a survey that asks patients about their pain, other symptoms, daily function, quality of life, and recreational activities. Nearly 80% of study participants improved above the minimal important change (MIC), with an average improvement over baseline of 2.2 times the MIC.

Osteoarthritis is a progressive joint disorder caused by painful inflammation of soft tissue, which leads to thinning of cartilage and joint damage in the knees, hips, fingers and spine.

Results from the PSC study have been submitted to the FDA for review. The company hopes to get approval for a larger, Phase 2 randomized study of its stem cell therapy later this year.

We are pleased at the strong safety profile and efficacy results in this FDA-approved clinical study of stem cell therapy for knee osteoarthritis, said PSC founder and CEO, Dr. Bob Harman. We are proud to have reached this milestone in our first FDA approved clinical trial. This data supports our progress in the larger placebo-controlled clinical study.

While the FDA has approved hundreds of clinical trials of stem cells, it has not approved a single stem cell product as a treatment for arthritis or any orthopedic condition. That hasnt stopped stem cell clinics from offering regenerative medicine to patients or veterinarians from using it on animals.

VetStem Biopharma, the parent company of PSC, pioneered the use of adipose derived stem cells in veterinary medicine. Its laboratory has processed stem cells for nearly 14,000 dogs, cats, horses and other animals for use by veterinarians in the U.S. and Canada.

The 15 years of veterinary experience with adipose derived stem cell therapy of our parent company, VetStem Biopharma, provided the basis for our FDA study submission and approval and provided valuable insights into the study design and conduct, said Harman.

In addition to the Phase 2 trial for osteoarthritis, PSC plans to pursue FDA approval for a stem cell trial to treat traumatic brain injuries in humans. A clinical study using PSCs stem cell platform to treat respiratory distress syndrome in COVID-19 patients is currently underway.

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Positive Results From Stem Cell Trial for Knee Osteoarthritis - Pain News Network

GOLDEN, CO / ACCESSWIRE / April 3, 2021 / Vitro Biopharma, Inc. (formerly Vitro Diagnostics, Inc.) announced the appointment of Dr. Caroline Mosessian, PhD, DRSc, FACMPE, ACHE as its acting Director of Regulatory Affairs. Dr. Mosessian has an extensive background in regulatory science including a PhD, MS and Masters in Healthcare Administration degrees from USC in LA. In 2016 she was honored with the prestigious Top Ranked US Executive Award awarded to the top 1% of the millions of active executives in the United States. She is a trusted advisor for strategic development and operations to a variety of technology firms promoting innovation excellence to enhance quality of life for patients, caregivers and providers while optimizing outcomes and overall corporate success. In addition to regulatory expertise, she has extensive experience in the development, management and licensing of intellectual property, government and private fund raising, strategic planning and clinical research operations. She is fluent in several languages that support her international business development skills. She is also actively involved in local, national and international charitable organizations that emphasize humanitarian aid.

She has led numerous clinical studies of medical devices and pharmaceuticals through regulatory agency approval including the FDA and EMA leading to successful development of multi-million dollar clinical programs. She presently assists Vitro Biopharma in the guidance, drafting and submission of its pending IND phase I application to the FDA (Randomized, Double-blinded, placebo-controlled study of the safety and efficacy of therapeutic treatment with AlloRx Stem Cells in adults with COVID-19). As a result, the FDA has authorized several expanded access/compassionate use INDs that employ IV infusion of AlloRx Stem Cells in the treatment of COVID-19 patients.

These results together with several additional clinical studies using MSCs are now providing substantial clinical evidence of safety and efficacy of stem cell therapy for COVID-19. Furthermore, since MSC therapy is independent of the genome of the virus, this MSC therapy is likely to be effective in treatment of COVID-19 patients infected with new variants resulting from viral mutation.

Dr. Jack Zamora, MD and CEO said, "We are elated to add Dr Mosessian to our regulatory team targeting FDA approval of AlloRx Stem Cells. She has been instrumental in establishing a strong working relationship between Vitro Biopharma and the FDA. She will also be a key driver of the execution of our pending Phase I trial and future INDs targeting additional indications of AlloRx Stem Cells."

Dr. Mosessian said, "I am inspired by Vitro Biopharma's mission to deliver innovative solutions and access to regenerative therapies to deliver unmet needs of the vulnerable patients. I feel fortunate to become part of the team thriving to achieve such an ambitious goal."

John Evans C.F.O. and Chairman of the Board said "We are pleased to have Caroline join the Board of Directors of the company, she adds such a wide breadth of experience in the regulatory, clinical and legal areas of board governance.

ABOUT VITRO BIOPHARMA

Out of years of research, we developed our patent-pending and proprietary line of umbilical cord derived stem cells AlloRx Stem Cells now being used in offshore regenerative medicine clinical trials. Our stem cells are used in regenerative medicine clinical trials with our partner in the Cayman Islands http://www.DVCStem.com. We have a recently approved clinical trial using our AlloRx Stem Cells to treat musculoskeletal conditions at The Medical Pavilion of the Bahamas http://www.tmp-bahamas.com in Nassau. Our nutraceutical stem cell activation product, STEMulize complements AlloRx Stem Cells as an adjuvant therapy to optimize therapeutic outcomes.

Vitro Biopharma has a proprietary and scalable manufacturing platform to provide stem cell therapies to critically ill Coronavirus patients and other conditions including multiple sclerosis, OA, Crohn's disease, and numerous medical conditions that are under-treated by the current standard of care. Our cGMP manufacturing is CLIA, ISO9001, ISO13485 certified and we are FDA registered. Our stem cells have been shown to be safe and effective in Phase I clinical trials.

Forward-Looking Statements

Statements herein regarding financial performance have not yet been reported to the SEC nor reviewed by the Company's auditors. Certain statements contained herein and subsequent statements made by and on behalf of the Company, whether oral or written may contain "forward-looking statements". Such forward-looking statements are identified by words such as "intends," "anticipates," "believes," "expects" and "hopes" and include, without limitation, statements regarding the Company's plan of business operations, product research and development activities, potential contractual arrangements, receipt of working capital, anticipated revenues, and related expenditures. Factors that could cause actual results to differ materially include, among others, acceptability of the Company's products in the market place, general economic conditions, receipt of additional working capital, the overall state of the biotechnology industry and other factors set forth in the Company's filings with the Securities and Exchange Commission. Most of these factors are outside the control of the Company. Investors are cautioned not to put undue reliance on forward-looking statements. Except as otherwise required by applicable securities statutes or regulations, the Company disclaims any intent or obligation to update publicly these forward-looking statements, whether as a result of new information, future events or otherwise.

CONTACT:Dr. Jack Zamora, MDChief Executive OfficerVitro Biopharma, Inc.(303) 999-2130 x 1www.vitrobiopharma.com

SOURCE: Vitro Diagnostics, Inc.

View source version on accesswire.com: https://www.accesswire.com/638885/Vitro-Biopharma-Retains-Leading-Health-Care-Executive-as-Acting-Director-of-Regulatory-Affairs-Director

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Vitro Biopharma Retains Leading Health Care Executive as Acting Director of Regulatory Affairs & Director - Benzinga

The Latest Regenerative Medicine market evaluates the capabilities, organizations, infrastructure, determines measures to achieve success. Detailed Overview of the global Regenerative Medicine market allows the industry players to plan growth strategies and align them with their operating business models. The research study gives a better understanding of the key growth factors, transformations and risk management priorities in the global Regenerative Medicine market during the years 2021-2026.

It is a phenomenal compilation of important studies that explore the competitive landscape, segmentation, geographical expansion, and revenue, production, and consumption growth of the Regenerative Medicine Market. Players can use the accurate market facts and figures and statistical studies provided in the report to understand the current and future growth of the global Regenerative Medicine Market.

Research Report on Regenerative Medicine Market added by AllTheResearch consist of Growth Opportunities, Development Trends, and Forecast 2026. The global Regenerative Medicine Market size was valued at US$ 13.56 Mn in 2018 and is expected to grow at a CAGR of 23% for the forecast period ending 2026 reaching a Market value of US$ 55.67 Mn.

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Top players Covered in Regenerative Medicine Market Study are:

Above mentioned companies were scrutinized to assess the competitive landscape of the global Regenerative Medicine market. The report provides company profiles of each player. Each profile includes company product portfolio, business overview, company governance, company financials, business strategies, manufacturing locations, and production facilities, company sales, recent developments, and strategic collaborations & partnerships, new product launches, company segments, application diversification, and company strength and weakness analysis.

Ask Your Queries to our Analyst regarding Regenerative Medicine Report at https://www.alltheresearch.com/speak-to-analyst/232

This Regenerative Medicine market report provides insights on new trade regulations, import-export analysis, industry value chain analysis, market size, consumption, production analysis, capacity analysis, regional and segment market share, product launches, product pipeline analysis, the impact of Covid-19 on the supply chain, key regions, untapped markets, patent analysis, product approvals, continuous innovations, and developments in the Market.

Based on type, Regenerative Medicine market report split into

Based on Application Regenerative Medicine market is segmented into

Regional Analysis Covered in this Report are:

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Industry Overview of Regenerative Medicine: Market Report Based on Development, Scope, Share, Trends, Forecast to 2026 The Bisouv Network - The...

Newswise WINSTON-SALEM, NC - March 30, 2021 - Personalized medicine research for aggressive abdominal cancers at Wake Forest Baptist Health received a boost from a $2.5 million grant from the National Cancer Institute that supports research efforts at Wake Forest Organoid Research Center (WFORCE), a joint effort between the Wake Forest Baptist Comprehensive Cancer Center and the Wake Forest Institute for Regenerative Medicine (WFIRM) to tailor personalized therapy for patients.

The funding supports development of a new drug testing platform to predict treatment outcomes for patients. The platform leverages tissue bioengineering advances and genomic technologies to reconstruct and grow patient-derived tumor organoids (i.e., fragments of a patients cancer) in the presence of different drugs to predict clinical responses of patients and guide treatment selection.

Creation of an organoid begins with a tissue biopsy of the tumor. Cells from this biopsy are then used to grow small tumors called organoids in the lab which behave similarly to the original tumor. The organoid model can accurately represent what occurs inside a patients body. Lastly, the best chemotherapy treatment is chosen by exposing the organoids to the various potential treatments and observing their response.

Konstantinos Votanopoulos, M.D., Ph.D., professor of surgery and director of WFORCE, and Lance D. Miller, Ph.D., associate professor in cancer biology, are the principal investigators of the grant, with Shay Soker, Ph.D., chief science officer and WFIRM professor, as a co-investigator.

WFORCE, which brings together researchers and clinicians to leverage the use of tissue organoid technology to tailor personalized therapy for patients, was formed in early 2020. To be awarded a competitive R01 grant of this size speaks to the need and transformational potential of WFORCE which combines world class multi-disciplinary clinical trial and patient care expertise through the NCI-designated Wake Forest Baptist Comprehensive Cancer Center and ground-breaking innovation and technology through WFIRM.

Every time cancer cells multiply, they generate the next generation of cancer cells with new properties, Votanopoulos said. As the cancer progresses, the patient ends up with not just a single tumor, but many different tumor clones with variable biologic behavior and response to treatment. Accurate mapping of tumor clonality, combined with response of each clone to therapy is the key for the development of personalized treatment strategies tailored to each patient separately.

Specifically, the research will look at determining clonality-based treatment response of high prevalence cancers such as colon, as well as very rare cancers with incidence less than 1 per 100,000 patients, such as appendiceal, that have spread throughout the abdomen where they grow as metastatic lesions on the surfaces of different organs.

How patients respond to treatment varies widely, and this represents a major clinical challenge our grant seeks to address, Miller said. This genetic variation that occurs when the cancer cells multiply is believed to explain why most, but not all of a patients cancer can initially respond well to chemotherapy, but eventually return in a drug-resistant form.

Soker said the project will generate new knowledge of how certain mutations, alone or in combination, impact response to specific drugs, adding that results of these studies will be leveraged in a future clinical trial.

Other key personnel on the grant are surgeon Edward A Levine, MD, pathologist Stacey ONeill, MD, tumor immunologist David Soto-Pantoja, MD,and bioinformatics expert Guangxu Jin, MD.

About the Comprehensive Cancer Center: The center is designated by the National Cancer Institute (NCI) as acomprehensive cancer center, one of three in North Carolina, and one of 51 in the country and has held this designation continuously since 1990. The designation recognizes Wake Forest for the highest levels of expertise and a commitment to patient care, cancer research, including clinical trials, and education. The rapid pace of discovery and the early availability of many new cancer treatments at NCI-designated Comprehensive Cancer Centers, gives us an advantage in offering our cancer patients early access to the latest therapies and treatment options, sometimes even months or years before non-NCI cancer centers.Wake Forest has a team of 120 clinicians representing all aspects of cancer care including those in the fields ofhematology and oncology,gynecologic oncology,radiation oncology,surgical oncologyandcolon and rectal surgery.

About the Wake Forest Institute for Regenerative Medicine:The Wake Forest Institute for Regenerative Medicine is recognized as an international leader in translating scientific discovery into clinical therapies, with many world firsts, including the development and implantation of the first engineered organ in a patient. Over 400 people at the institute, the largest in the world, work on more than 40 different tissues and organs. A number of the basic principles of tissue engineering and regenerative medicine were first developed at the institute. WFIRM researchers have successfully engineered replacement tissues and organs in all four categories flat structures, tubular tissues, hollow organs and solid organs and 15 different applications of cell/tissue therapy technologies, such as skin, urethras, cartilage, bladders, muscle, kidney, and vaginal organs, have been successfully used in human patients. The institute, which is part of Wake Forest School of Medicine,is located in theInnovation Quarterin downtown Winston-Salem, NC,andis driven by the urgent needs of patients. The institute is making a global difference in regenerative medicine through collaborations with over 400entitiesand institutions worldwide,through its government, academic and industry partnerships, its start-up entities, and through major initiatives in breakthrough technologies, such as tissue engineering, cell therapies, diagnostics, drug discovery, biomanufacturing, nanotechnology, gene editing and 3D printing.

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$2.5M award to fund joint organoid research program at Wake to treat aggressive cancers - Newswise

insightSLICE provide a deep analysis of the Global Regenerative Medicine Marketwhich evaluates business solutions, assess, research and development, application, benefits, advantage, scope, and operations. This report offers an in-depth analysis and development ofindustry major manufacturers, key drivers, opportunity, challenge, international suppliers also deep study on risks and entry barriers. It also offers competitive analysis on thelatest technology, trend, innovation, future scope, Industry Share, sales, revenue generation, investment analysis, and overall business scenario.

These studies also involve the important achievements of the market, research & development, new product launch, regional growth, leading competitors over the universal and local scale. The industry report analysis and insights of manufacturers steeringgrowth, revenue, share, supply, opportunity, challenges, and restrain development. It also the expansion of Industry regional as well as global fats and figure.

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Competitive landscape:

Competitive analysis was carried out in the report. This competitive analysis provides insightful data about industry market leaders. The purpose is to help customers understand the existing market participants and potential market participants in the industry. The way the report is made allows customers not only to make the right decisions about the industry, but also to maintain steady growth in the industry in the long run. The purpose is to guide customers towards the steady development of their industry growth.

Manufacturers covered in this report are:

3M Group, Novartis AG and Integra Lifesciences Holdings Corporation.

An overview of the markets regional outlook:

The Global Regenerative Medicine report provides information about market regions, which are further broken down into sub-regions and countries. In addition to market share in each country and region, this chapter of this report also contains information about profit opportunities. This chapter of the report mentions the share and market growth rate of each region, country, and subregion over the estimated time period.

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The impact of Covid-19 on this market:

The coronavirus (COVID-19) pandemic has affected every aspect of global life. The study comprehensively covers the impact of the COVID-19 pandemic on the Global Regenerative Medicine market and its key market segments. In addition, it covers the current and future impact of the pandemic and provides the post-COVID-19 situation to gain a deeper understanding of trends and dynamic changes in market conditions.

In addition, insightSLICE has access to a wide range of regional and global well-known paid databases, which helps the company determine regional and global market trends and dynamics. The research also includes key strategic developments, including R&D, new product launches, mergers and acquisitions, agreements, collaborations, partnerships, joint ventures, and the regional development of major competitors operating in the market on a global and regional scale.

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Finally, the Global Regenerative Medicine Market report is a source of convincing research reports that can accelerate your business exponentially. The report provides the main regional settings, economic conditions, and the value, benefits, restrictions, generation, supply, demand, and market development speed and figures of the project.

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Regenerative Medicine Market is Expected to Develop at a Substantial CAGR in the Coming Years 2020 to 2030 | 3M Group, Novartis AG and Integra...

DUBLIN, April 1, 2021 /PRNewswire/ -- The "Cell Therapy Market Forecast to 2027 - COVID-19 Impact and Global Analysis By Therapy Type; Product; Technology; Application; End User, and Geography" report has been added to ResearchAndMarkets.com's offering.

According to this report the global cell therapy market is expected to reach US$ 12,563.23 million by 2027 from US$ 7,260.50 million in 2019. It is estimated to grow at a CAGR of 7.2% from 2020-2027. The growth of the market is attributed to increasing prevalence of chronic diseases, rising adoption of regenerative medicines, and surging number of approvals for cell-based therapies. However, the high cost of cell therapy manufacturing hinders the growth of the market.

The cell therapy market, based on therapy type, is bifurcated into allogeneic and autologous. In 2019, the allogeneic segment accounted for a larger share owing to the availability of substantial number of approved products for clinical use. For instance, in 2018, Alofisel developed by TiGenix (Takeda) is the first allogeneic stem cell-based therapy approved for use in Europe.

Chronic diseases, such as cardiovascular disorders, neurological disorders, autoimmune disorders, and cancer, are the leading causes of death and disability worldwide. As per the Centers for Disease Control and Prevention (CDC), in 2019, nearly 6 in 10 people suffered from at least one chronic disease in the US. Cardiovascular diseases (CVDs) are a significant cause of mortality owing to the hectic lifestyle. As per the World Health Organization (WHO), CVDs are the number 1 cause of death globally, taking an estimated 17.9 million lives each year. Cancer is among the leading causes of mortality worldwide, and the disease affects a huge population; therefore, it acts as a huge financial burden on society. According to the WHO, in 2018, ~9.6 million deaths occurred due to cancer globally. However, growing research on developing effective treatments for the disease is positively affecting the market growth. Gene therapy and cell therapy are transforming the cancer treatment landscape; for example, Novartis Kymriah is used to treat diffuse large B-cell lymphoma. The launches of more such products would be driving the demand for cell therapy, thus driving the growth of the cell therapy market in the coming years.

The COVID-19 outbreak was first reported in Wuhan (China) in December 2019. The pandemic is causing massive disruptions in supply chains, consumer markets, and economy across the world. As the healthcare sector is focusing on saving lives of COVID-19 patients, the demand for cell therapy is reducing worldwide.

Vericel Corporation; MEDIPOST; NuVasive, Inc.; Mesoblast Limited; JCR Pharmaceuticals Co. Ltd.; Smith & Nephew; Bristol-Myers Squibb Company; Cells for Cells; Stemedica Cell Technologies, Inc; and Castle Creek Biosciences, Inc. are among the companies operating in the cell therapy market.

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Key Topics Covered:

1. Introduction1.1 Scope of the Study1.2 Research Report Guidance1.3 Market Segmentation1.3.1 Global Cell Therapy Market - By Therapy Type1.3.2 Global Cell Therapy Market - By Product1.3.3 Global Cell Therapy Market - By Technology1.3.4 Global Cell Therapy Market - By Application1.3.5 Global Cell Therapy Market - By End User1.3.6 Global Cell Therapy Market - By Geography

2. Cell Therapy Market - Key Takeaways

3. Research Methodology3.1 Coverage3.2 Secondary Research3.3 Primary Research

4. Global Cell therapy- Market Landscape4.1 Overview4.2 PEST Analysis4.2.1 North America - PEST Analysis4.2.2 Europe- PEST Analysis4.2.3 Asia Pacific- PEST Analysis4.2.4 Middle East and Africa - PEST Analysis4.2.5 South and Central America - PEST Analysis4.3 Expert Opinions

5. Global Cell Therapy Market - Key Industry Dynamics5.1 Key Market Drivers5.1.1 Increasing Prevalence of Chronic Diseases5.1.2 Rising Adoption of Regenerative Medicines5.1.3 Increasing Number of Approvals for Cell-Based Therapies5.2 Key Market Restraints5.2.1 High Cost of Cell Therapy Manufacturing5.3 Key Market Opportunities5.3.1 Increasing Adoption of Cell Therapy in Developing Regions5.4 Future Trends5.4.1 Shift Toward Automated Cell Therapy Manufacturing5.5 Impact Analysis of Drivers and Restraints

6. Cell therapy Market - Global Analysis6.1 Global Cell therapy Market Revenue Forecast And Analysis6.2 Global Cell therapy Market, By Geography - Forecast And Analysis6.3 Market Positioning

7. Cell therapy Market Analysis - By Therapy Type7.1 Overview7.2 Cell therapy Market Revenue Share, by Therapy Type (2019 and 2027)7.3 Allogeneic7.3.1 Overview7.3.2 Allogeneic: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)7.4 Autologous7.4.1 Overview7.4.2 Autologous: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)

8. Cell therapy Market Analysis - By Product8.1 Overview8.2 Cell therapy Market Revenue Share, by Product (2019 and 2027)8.3 Consumables8.3.1 Overview8.3.2 Consumables: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)8.4 Equipment8.4.1 Overview8.4.2 Equipment: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)8.5 Systems and Software8.5.1 Overview8.5.2 Systems and Software: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)

9. Cell therapy Market Analysis - By Technology9.1 Overview9.2 Cell therapy Market Revenue Share, by Technology (2019 and 2027)9.3 Viral Vector Technology9.3.1 Overview9.3.2 Viral Vector Technology: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)9.4 Genome Editing Technology9.4.1 Overview9.4.2 Genome Editing Technology: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)9.5 Somatic Cell Technology9.5.1 Overview9.5.2 Somatic Cell Technology: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)9.6 Cell Immortalization Technology9.6.1 Overview9.6.2 Cell Immortalization Technology: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)9.7 Cell Plasticity Technology9.7.1 Overview9.7.2 Cell Plasticity Technology: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)9.8 Three-Dimensional Technology9.8.1 Overview9.8.2 Three-Dimensional Technology: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)

10. Cell therapy Market Analysis - By Application10.1 Overview10.2 Cell therapy Market Revenue Share, by Application (2019 and 2027)10.3 Oncology10.3.1 Overview10.3.2 Oncology: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)10.4 Cardiovascular10.4.1 Overview10.4.2 Cardiovascular: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)10.5 Orthopedic10.5.1 Overview10.5.2 Orthopedic: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)10.6 Wound Management10.6.1 Overview10.6.2 Wound Management: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)10.7 Other Applications10.7.1 Overview10.7.2 Other Applications: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)

11. Cell therapy Market Analysis - By End User11.1 Overview11.2 Cell therapy Market Share, by End User, 2019 and 2027, (%)11.3 Hospitals11.3.1 Overview11.3.2 Hospitals: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)11.4 Research Institutes11.4.1 Overview11.4.2 Research Institutes: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)11.5 Others11.5.1 Overview11.5.2 Others: Cell therapy Market - Revenue and Forecast to 2027 (US$ Million)

12. Cell therapy Market - Geographic Analysis12.1 North America: Cell Therapy Market12.2 Europe: Cell therapy Market12.3 Asia Pacific: Cell Therapy Market12.4 Middle East and Africa: Cell Therapy Market12.5 South and Central America: Cell Therapy Market

13. Impact of COVID-19 Pandemic on Global Cell Therapy Market13.1 North America: Impact Assessment of COVID-19 Pandemic13.2 Europe: Impact Assessment of COVID-19 Pandemic13.3 Asia-Pacific: Impact Assessment of COVID-19 Pandemic13.4 Middle East & Africa: Impact Assessment of COVID-19 Pandemic13.5 South & Central America: Impact Assessment of COVID-19 Pandemic

14. Cell Therapy Market- Industry Landscape14.1 Overview14.2 Growth Strategies Done by the Companies in the Market, (%)14.3 Organic Developments14.3.1 Overview14.4 Inorganic Developments14.4.1 Overview

15. Company Profiles15.1 Vericel Corporation15.1.1 Key Facts15.1.2 Business Description15.1.3 Products and Services15.1.4 Financial Overview15.1.5 SWOT Analysis15.1.6 Key Developments15.2 MEDIPOST15.2.1 Key Facts15.2.2 Business Description15.2.3 Products and Services15.2.4 Financial Overview15.2.5 SWOT Analysis15.2.6 Key Developments15.3 NuVasive, Inc.15.3.1 Key Facts15.3.2 Business Description15.3.3 Products and Services15.3.4 Financial Overview15.3.5 SWOT Analysis15.3.6 Key Developments15.4 Mesoblast Limited15.4.1 Key Facts15.4.2 Business Description15.4.3 Products and Services15.4.4 Financial Overview15.4.5 SWOT Analysis15.4.6 Key Developments15.5 JCR Pharmaceuticals Co. Ltd.15.5.1 Key Facts15.5.2 Business Description15.5.3 Products and Services15.5.4 Financial Overview15.5.5 SWOT Analysis15.5.6 Key Developments15.6 Smith & Nephew15.6.1 Key Facts15.6.2 Business Description15.6.3 Products and Services15.6.4 Financial Overview15.6.5 SWOT Analysis15.6.6 Key Developments15.7 Bristol-Myers Squibb Company15.7.1 Key Facts15.7.2 Business Description15.7.3 Products and Services15.7.4 Financial Overview15.7.5 SWOT Analysis15.7.6 Key Developments15.8 Cells for Cells15.8.1 Key Facts15.8.2 Business Description15.8.3 Products and Services15.8.4 Financial Overview15.8.5 SWOT Analysis15.8.6 Key Developments15.9 Stemedica Cell Technologies, Inc15.9.1 Key Facts15.9.2 Business Description15.9.3 Products and Services15.9.4 Financial Overview15.9.5 SWOT Analysis15.9.6 Key Developments15.10 Castle Creek Biosciences, Inc.15.10.1 Key Facts15.10.2 Business Description15.10.3 Products and Services15.10.4 Financial Overview15.10.5 SWOT Analysis15.10.6 Key Developments

16. Appendix16.1 About the Publisher16.2 Glossary of Terms

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Worldwide Cell Therapy Industry to 2027 - Increasing Prevalence of Chronic Diseases is Driving the Market - PRNewswire

Regenerative medicine is a segment of translational research in molecular biology and tissue engineering. It involves the process of regeneration of human cells, tissues, or organs to re-establish their normal functions through stimulation of bodys repair system. They are widely used in the treatment of many degenerative disorders occurring in the areas of dermatology, orthopedic, cardiovascular and neurodegenerative diseases. Stem cell therapy is the available tool in the field of translational regenerative medicine. It has gained importance in the past few years as it is a bio-based alternative to synthetic options. Stem cells have high power of regeneration. Hence, these enable production of other cells in the body. This has increased demand for stem cell therapy in the treatment of degenerative diseases. Currently, stem cell therapy has applications in the treatment of diseases such as autism, cancer, retinal diseases, heart failure, diabetes, rheumatoid arthritis, Alzheimers. Extensive research is being carried out on stem cell therapy. The Centre for Commercialization of Regenerative Medicine (CCRM) has reported around 1900 active clinical trials undergoing currently. It also reported 574 active industry-sponsored cell therapy clinical studies, 50 of these are in phase 3 development. Hence, stem cell therapy is projected to contribute to the growth of the translational regenerative medicine market. However, ethical issues in the use of embryonic stem cells is likely to restrain the market.

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Rising prevalence of degenerative diseases, aging population, rapid growth of emerging countries, and technical advancements in developed countries are the major factors fueling the growth of the translational regenerative medicine market.

The global translational regenerative medicine market has been segmented based on product type, therapy, application, and region. In terms of product type, the market has been categorized into cellular and acellular. The cellular segment dominated the global market in 2016. Based on therapy, the global translational regenerative market has been segmented into cell therapy, gene therapy, immunotherapy, and tissue engineering. Immunotherapy is projected to be the fastest growing segment during the forecast period. In terms of application, the market has been segmented into orthopedic & musculoskeletal, cardiology, diabetes, central nervous system diseases, dermatology, and others. Cardiology and orthopedic & musculoskeletal are anticipated to be the fastest growing segments of the global translational regenerative medicine market.In terms of region, the global translational regenerative medicine market has been segmented into North America, Latin America, Europe, Asia Pacific, and Middle East & Africa. North America dominated the global regenerative medicine market owing to a large number of leading companies and expansion of research and development activities in the U.S. Increased medical reimbursement and advanced health care also drive the market in the region. Orthopedic is the leading application segment contributing to the growth of the market in the region. Asia Pacific is forecasted the huge growth because of large consumer pool, rising income, and health care expenditure. However, the market in Asia Pacific could face challenges such as high cost of bio-based medicines and stringent regulatory policies.

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The global translational regenerative medicine market is dominated by key players such as CONMED Corporation, Arthrex, Inc., Organogenesis, Inc., Nuvasive, Inc., Osiris Therapeutics, Inc., Celgene Corporation, Brainstorm Cell Therapeutics Inc. and Medtronic.

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The following regional segments are covered comprehensively:

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Translational Regenerative Medicine Market: Immunotherapy is projected to be the fastest growing segment during the forecast period - BioSpace

Scientists in the field of regenerative medicine have long been interested in using muscle stem cells to repair injuries, but growing the cells in the lab has proven to be challenging. Now, a team of Australian researchers is suggesting an alternative: a naturally occurring protein that regenerates muscle.

A team from the Australian Regenerative Medicine Institute at Monash University discovered that a protein called NAMPT (nicotinamide phosphoribosyltransferase) stimulates the growth of muscle stem cells and healing in zebrafish and mice. They published their findings in the journal Nature.

The researchers started by studying the cells that migrated to injury sites in zebrafish. They discovered that a particular group of immune cells called macrophages stimulated the regeneration of muscle stem cells.

Macrophages are known to migrate to injury sites, where some remove debris that appears immediately and others stay for long-term cleaning. But the Australian scientists discovered eight genetically distinct macrophagesonly one of which seemed to be involved in the regeneration of muscle stem cells.

They went on to discover that the macrophages with those regenerative abilities released NAMPT. So they tried removing the macrophages from the fish and then adding NAMPT to the aquarium water. It worked: Muscle stem cells started to grow and promote healing, showing that the protein took over for the missing macrophages, the researchers said.

RELATED: Stem cells don't repair injured hearts, but inflammation might, study finds

Several regenerative medicine research teams are focused on harnessing the healing power of macrophages. Researchers from the Cincinnati Children's Hospital Medical Center, for example, discovered that the inflammatory response to stem-cell injections into the heart activated macrophages, which in turn promoted healing.

The Monash-led research team did further studies with NAMPT, which included placing patches that contained the protein into mouse models of muscle-wasting disease. They observed significant muscle healing and are now in discussions with biotech companies about taking the technique into clinical trials, they said in a statement.

They believe NAMPT-based therapies could prove useful in treating a range of conditions including muscular dystrophy, limb injuries and muscle wasting due to aging.

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Zebrafish reveal regenerative protein that could inspire new treatments for muscle-wasting diseases and aging - FierceBiotech

Bloomberg

(Bloomberg) -- Crown Resorts Ltd. Chief Executive Officer Ken Barton stepped down, bowing to days of pressure after a scathing regulatory report found the Australian casino operator facilitated money laundering and wasnt fit to hold a license in Sydney.Barton will leave immediately, Melbourne-based Crown said in a statement Monday. Helen Coonan will lead the company as executive chairman while the board oversees a search for a new CEO.The report last week by former judge Patricia Bergin was particularly critical of Barton, saying he didnt have the skills for the job. His departure leaves Coonan to find a path out of a crisis that has left Australias largest casino company also facing regulatory pressure at its main operations in Melbourne and Perth.The board is determined to maintain the momentum as Crown takes significant steps to improve our governance, compliance and culture, Coonan said. I will continue to lead on implementation of Crowns ambitious reform program.Crown shares rose 1.1% to A$10.00 in early trading in Sydney, valuing the company at A$6.8 billion ($5.3 billion).After a year-long inquiry for the state gaming watchdog in New South Wales, Bergin recommended an overhaul of Crown before the company could start gaming operations at its new A$2.2 billion Sydney casino. The New South Wales gaming regulator, the Independent Liquor and Gaming Authority, is due to consider the report at a board meeting on Feb. 17.Barton is no match for what is needed at the helm of a casino licensee, Bergin wrote. Barton clung on and as recently as Friday was still assessing his position. He became CEO of Crown in early 2020 after a decade as chief financial officer.Both board nominees of Crowns biggest shareholder, James Packer, left the day after the report was released. Director Andrew Demetriou also resigned last week.Barton disclosed last year during Bergins investigation that Crown hadnt yet analyzed the accounts that were reportedly used by money launderers. He was also unaware for years that a major junket operator had a cash desk at Crowns Melbourne casino, even though the setup posed a money-laundering risk.Packers Casino Dream Dashed as Crown Seen Unfit for LicenseBartons evidence during the inquiry demonstrated a serious lack of judgment, Bergin wrote. His problems will not be cured by the appointment of people expert in the field who report to him, she said.Philip Crawford, chair of the Independent Liquor and Gaming Authority, said Feb. 11 there was a certain obviousness to the notion that Barton should step down.(Adds share price, regulatory pressure on Crown in third paragraph.)For more articles like this, please visit us at bloomberg.comSubscribe now to stay ahead with the most trusted business news source.2021 Bloomberg L.P.

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Global Regenerative Medicine Partnering Deals, Terms and Agreements Directory 2014-2020: Analysis of the Structure of Regenerative Medicine Agreements...

The globalREGENERATIVE MEDICINE marketis constantly evolving and presenting new avenues to stakeholders. The study on the REGENERATIVE MEDICINE market presents a comprehensive assessment of economic, social, and policy factors shaping the changing dynamic. The research offers data-validated insights into current opportunities in various segments and possible avenues during forecast period of 2020 20xy. The trends shaping the value chain assessment, degree of control by incumbent players, intensity of competition are analysed in the study with succinct recommendations and opinionsby market analysts.

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The study offers strategic scenario planning for the recent disruptions caused by Covid-19, a pandemicthatis still emerging. Further, the report has come out with popular strategic moves being made by players to regain agility and come on the growth trajectory as in the pre-Covid era. The research hasgleaned over the change in perspectives of governments and investors and the changing demand dynamic in various end-use industries for evaluating the growth dynamics on the REGENERATIVE MEDICINE market.

The factors that shaped high value-grab opportunities in various regions and consumer segments in the REGENERATIVE MEDICINE market are scrutinized, along with the inherent possibilities in the allied industries.The REGENERATIVE MEDICINE market was pegged at US$ xy mn/Bn and is projected to touch the mark of ab Mn/cd Bn by the end of the forecast period.The researchanalysts also point outsegments that emergedas data outliers,and attribute reasons for the same to offera holistic understatingofgrowth dynamics.

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11 February 2021

An exciting discovery by Monash University scientists may lead to faster recovery from muscle injury and wasting diseases.

When we tear a muscle stem cells within it repair the problem. We can see this occurring not only in severe muscle wasting diseases such as muscular dystrophy and in war veterans who survive catastrophic limb injuries, but also in our day to day lives when we pull a muscle. Also when we age and become frail we lose much of our muscle and our stem cells dont seem to be able to work as well as we age.

These muscle stem cells are invisible engines that drive the tissue's growth and repair after such injuries. But growing these cells in the lab and then using them to therapeutically replace damaged muscle has been frustratingly difficult.

Researchers at the Australian Regenerative Medicine Institute at Monash University in Melbourne, Australia have discovered a factor that triggers these muscle stem cells to proliferate and heal. In a mouse model of severe muscle damage, injections of this naturally occurring protein led to the complete regeneration of muscle and the return of normal movement after severe muscle trauma.

The research led by Professor Peter Currie, Director of Monash Universitys Australian Regenerative Medicine Institute, is published today in Nature.

The scientists studied the regeneration of skeletal muscle in zebrafish, fast becoming the go-to animal model for the study of stem cell regeneration because the fish are quick to reproduce, easier to experimentally manipulate, and share at least 70 percent of their genes with humans. It is also transparent which allows the scientists to witness the actual regeneration in living muscle.

By studying the cells that migrated to a muscle injury in these fish the scientists identified a group of immune cells, called macrophages, which appeared to have a role in triggering the muscle stem cells to regenerate. What we saw were macrophages literally cuddling the muscle stem cells, which then started to divide and proliferate. Once they started this process, the macrophage would move on and cuddle the next muscle stem cell, and pretty soon the wound would heal, Professor Currie said

Macrophages are the cells that flock to any injury or infection site in the body, removing debris and promoting healing. They are the clean up crew of the immune system, Professor Currie said.

It has long been thought that two types of macrophages exist in the body: those that move to the injury rapidly and remove debris, and those that come in slower and stick around doing the longer term clean-up.

The research team, however, found that there were in fact eight genetically different types of macrophages in the injury site, and that one type, in particular, was the cuddler. Further investigation revealed that this affectionate macrophage released a substance called NAMPT. By removing these macrophages from the zebrafish and adding the NAMPT to the aquarium water the scientists found they could stimulate the muscle stem cells to grow and heal effectively replacing the need for the macrophages.

Importantly recent experiments placing a hydrogel patch containing NAMPT into a mouse model of severe muscle wasting led to what Professor Currie called significant replacement of the damaged muscle.

The researchers are now in discussions with a number of biotech companies about taking NAMPT to clinical trials for the use of this compound in the treatment of muscle disease and injury.

Read the full paper in Nature titled:Macrophages provide a transient muscle stem cell miche via NAMPT secretion.

DOI: 10.1038/s41586-021-03199-7

Read more from Professor Peter Currie onMonash Lens.

About The Australian Regenerative Medicine Institute at Monash University

The Australian Regenerative Medicine Institute is one of the largest regenerative medicine and stem cell research organisations in the world and Australias only research institute specialising in regeneration and stem cells.Located on the Clayton campus of Monash University, researchers at ARMI focus on understanding the basic mechanisms of the regenerative process, aiming to eventually enable doctors to prevent, halt and reverse damage to vital organs due to disease, injury or genetic conditions.

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Reversing severe muscle wasting in disease, aging and trauma - Monash University

PHOENIX, Feb. 8, 2021 /PRNewswire/ --(OTC-CELZ) Creative Medical Technology Holdings Inc. announced today recruitment of Dr. Caigan Du, Associate Professor at the University of British Columbia to the Company's Scientific Advisory Board.

Dr. Du is a top researcher in the area of molecular and immunological understanding of kidney failure and transplant rejection. Dr. Du is funded by numerous national and international organizations including the Kidney Foundation and the Canadian Institutes of Health Research.

"I am honored to work with Creative Medical Technology Holdings in this fascinating field of leveraging reprogrammed immune cells for regenerating injured kidneys." Said Dr. Du. "To date people think about regenerative medicine and immunology as separate fields. It is very exciting to consider the possibility that immune cells can act as a catalyst for regenerative processes: this is the basis of the ImmCelz product."

ImmCelz is a personalized cell therapy generated by incubation of patient cells with allogeneic JadiCell stem cells under proprietary conditions. The JadiCell possess potent ability to reprogram the immune system, as exemplified in part by their ability to significantly extend survival of COVID patients in an FDA double blind, placebo controlled, clinical trial1. ImmCelz has been demonstrated effective in animal models of rheumatoid arthritis2, liver failure3, stroke4, type 1 diabetes5 and kidney failure6. Scientific studies suggest ImmCelz functions through secretion of a fundamentally important molecule called Hepatocyte Growth Factor7, as well as stimulation of T regulatory cells, a type of immune system cell that suppresses pathological immunity8.

"As a clinical-stage biotechnology company, having already commercialized other stem cell products, we understand the key to any success is based on the ability to attract scientific key opinion leaders." Said Timothy Warbington, President and CEO of Creative Medical Technology Holdings. "Dr. Du is a visionary and pioneer in understanding of kidney diseases and we wholeheartedly look forward to him joining our scientific advisory board."

The Advisory Board of Creative Medical Technology Holdings includes internationally renowned neurologist Santosh Kesari MD, Ph.D, the former head of cardiology at Cedar Sinai Medical Center Timothy Henry, MD and our Director Dr. Amit Patel, inventor of the JadiCell and the first physician to have implanted stem cells into the human heart.

About Creative Medical Technology HoldingsCreative Medical Technology Holdings, Inc. is a commercial stage biotechnology company specializing in regenerative medicine/stem cell technology in the fields of immunotherapy, urology, neurology and orthopedics and is listed on the OTC under the ticker symbol CELZ. For further information about the company, please visitwww.creativemedicaltechnology.com.

Forward Looking StatementsOTC Markets has not reviewed and does not accept responsibility for the adequacy or accuracy of this release. This news release may contain forward-looking statements including but not limited to comments regarding the timing and content of upcoming clinical trials and laboratory results, marketing efforts, funding, etc. Forward-looking statements address future events and conditions and, therefore, involve inherent risks and uncertainties. Actual results may differ materially from those currently anticipated in such statements. See the periodic and other reports filed by Creative Medical Technology Holdings, Inc. with the Securities and Exchange Commission and available on the Commission's website atwww.sec.gov.

Creativemedicaltechnology.comwww.StemSpine.comwww.Caverstem.comwww.Femcelz.com ImmCelz.com

1 Umbilical cord mesenchymal stem cells for COVID19 acute respiratory distress syndrome: A doubleblind, phase 1/2a, randomized controlled trial - Lanzoni - - STEM CELLS Translational Medicine - Wiley Online Library2 Creative Medical Technology Holdings Reports Positive Preclinical Data on ImmCelz Immunotherapy Product in Rheumatoid Arthritis Model | BioSpace3 Creative Medical Technology Holdings Announces Reversion of Liver Failure Using ImmCelz Personalized Cellular Immunotherapy in Preclinical Model | Nasdaq4 Creative Medical Technology Holdings Identifies Mechanism of Action of ImmCelz Stroke Regenerative Activity (prnewswire.com)5 Creative Medical Technology Holdings Announces Positive Data and Patent Filing Using ImmCelz to Treat Type 1 Diabetes (prnewswire.com)6 Creative Medical Technology Holdings Files Patent based on Positive Data on Renal Failure using ImmCelz Regenerative Immunotherapy (prnewswire.com)7 Creative Medical Technology Holdings Identifies and Files Patent on Novel Mechanism of ImmCelz Therapeutic Activity (apnews.com)8 Creative Medical Technology Holdings Identifies Mechanism of Action of ImmCelz Stroke Regenerative Activity (prnewswire.com)

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Creative Medical Technology Holdings Recruits Internationally Renowned Kidney Expert to Scientific Advisory Board - PRNewswire

VANCOUVER, BC, Feb. 10, 2021 /PRNewswire/ --Notch Therapeutics, Inc., a biotechnology company developing renewable, induced pluripotent stem cell (iPSC)-derived cell therapies for cancer, announced today the closing of an oversubscribed U.S. $85 million Series A financing. The financing was led by an exclusively healthcare-focused investment fund, with participation by existing investors Allogene Therapeutics, Inc. (NASDAQ: ALLO), Lumira Ventures, and CCRM Enterprises Holdings Ltd., an affiliate of Centre for Commercialization of Regenerative Medicine (CCRM); along with new investors EcoR1 Capital, a undisclosed leading global investment firm, Casdin Capital, Samsara BioCapital, and Amplitude Ventures. Proceeds from the financing will support the continuing development of Notch's portfolio of iPSC-derived T cell therapeutic product candidates and clinical readiness of the company's proprietary Engineered Thymic Niche (ETN) platform. The financing will also enable Notch to expand its team to support the company's future growth, including establishing operations in Seattle, in addition to the company's existing operations in Vancouver and Toronto.

"We are gratified to have the confidence of this exceptional group of investors and have them share in our vision that our platform can be game-changing for cell therapies by easing cell manufacturing and broadening their clinical and commercial potential," said David Main, President and Chief Executive Officer of Notch. "The level of interest in this financing round enabled us to far exceed our original capital-raising goals. With this support, Notch is well positioned to support our partners and advance development of our initial cell therapy products for patients with cancer."

Notch is applying its scalable Engineered Thymic Niche (ETN) technology platform to develop homogeneous and universally compatible, stem cell-derived cell therapies. To date, Notch has assembled a world-class scientific team and built a fully integrated, tightly controlled platform for generating and editing immune cells from clonal stem cells to enable development of a broad range of T cell therapeutics. Notch has an existing partnership with Allogene Therapeutics to apply Notch's proprietary ETN platform to develop CAR-targeted, iPSC-derived, off-the-shelf T cell or natural killer (NK) cell therapies for hematologic cancer indications.

"We have great confidence in Notch's high-caliber management team and the rigorous science underlying its research programs," said David Chang, M.D., Ph.D., President, Chief Executive Officer, and Co-Founder of Allogene and a member of the Notch Board of Directors. "We are impressed by the company's innovation and accomplishments and pleased to continue our support of Notch as the company advances the development of a new generation of cell therapies for cancer and other immune disorders."

About Notch Therapeutics (www.notchtx.com)Notch is developing a pipeline of cellular immunotherapies originating from pluripotent stem cells that are specifically engineered to address the underlying biology of complex disease systems. The company has unlocked the ability for large-quantity production of T cells and other cells from any source of stem cells to bring best-in-class cell therapies for cancer and other immune disorders to thousands of patients. The core of the Notch platform is the Engineered Thymic Niche (ETN), which enables precision control of cell fate during the differentiation and expansion of stem cells in suspension bioreactors without the need for feeder cells or serum. The ETN has the potential to generate immunotherapies with decreased variability, increased potency, and engineered improvements. The technology was invented in the laboratories of Juan-Carlos Ziga-Pflcker, Ph.D. at Sunnybrook Research Institute and Peter Zandstra, Ph.D., FRSC at the University of Toronto. Notch was founded by these two institutions, in conjunction with MaRS Innovation (now Toronto Innovation Acceleration Partners) and the Centre for Commercialization of Regenerative Medicine (CCRM), which initially incubated the company.

Contact:Mary MoynihanM2Friend Biocommunications802-951-9600[emailprotected]

SOURCE Notch Therapeutics

Notch Therapeutics

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Notch Therapeutics Closes $85 Million Series A Financing to Develop Pipeline of Renewable Stem Cell-Derived Cancer Immunotherapies - PRNewswire

WAALRE, Netherlands, Feb. 10, 2021 /PRNewswire/ -- IME Medical Electrospinning, a global leader in electrospun medical devices, today announced that it has entered into a collaboration with Dutch medical device company STENTiT, to join forces in the further development and production of regenerative endovascular support grafts(see video).These resorbable fibrous implants hold the promise to rebuild a new blood vessel inside the existing artery, by exploiting the natural healing response of the body.

IME's technological solutions enable the manufacturing of innovative devices like STENTiT's endovascular support grafts, which are aimed to mimic the natural human extracellular matrix for implants in the human body in nanometer and micrometer format. Human cells rebuild these matrices leading to new body tissue. This is in contrast to implants of traditional structures, which are seen as foreign and therefore can lead to scar tissue formation or rejection phenomena.

STENTiT is an emerging player in the field of regenerative medical devices, offering a breakthrough solution for cardiovascular interventions developing first-of-its-kind regenerative endovascular blood vessel implants. Using a catheter-based approach, it provides the ability to restore the artery without the need for an invasive surgical intervention. The aim is to ultimately restore the affected artery from the inside-out to provide a life-lasting solution.

Bart Sanders, CEO of STENTiT, says:

"We are thrilled to join forces with IME Medical Electrospinning to further optimize our fibrillated endovascular implants. IME is a highly innovative and leading company in the field of Medical Electrospinning, for which I'm confident that together we will spur the development of a superior and reproducible product, while getting STENTiT ready to scale."

Judith Heikoop, CEO of IME Medical Electrospinning, adds:

"We are extremely proud to have been able to expandourcollaborations with such a promising company like STENTiT. IME Medical Electrospinning develops medical devices in close collaboration with an ever-growing portfolio of customers and partners worldwide within the industry, the scientific environment, hospitals and medical institutes. This collaboration is testimony to our strategic goal to become a trusted partner worldwide in co-developing electrospun medical devices that will cause a revolution in the industry and will enable tissue rebuilding."

IME has set the worldwide standard in the co-development and production of scalable and reproducible nanometer and micrometer scaffolds that enable scientists to develop medical implants helping the human body to repair itself, such as heart valves, blood vessels, nerves, tendons, skin and bone. IME operates a brand new high-end GMP Laboratory and set of cleanrooms. With this the company is able to not only develop and manufacture its top-end proprietary electrospinning machines, but to also produce the actual scaffolds for the intended medical implants for their customers. The cleanroom facilities enable the production of Class I, II and III medical devices.

About Medical Electrospinning

Applying specific polymers, IME's advanced equipment creates fiber-based medical device solutions that mimic the natural human extracellular matrix in nanometer and micrometer format for implants and membranes in the human body. Human cells recognize these artificial matrices (scaffolds) as the body's own, facilitating the repair of the damaged tissue for heart valves, blood vessels, nerves, tendons, skin and bone etc. This is in contrast to implants and membranes of traditional structures, which are seen as foreign and therefore can lead to scar tissue or rejection phenomena. The MediSpinXL platform has been developed specifically for MedTech industrial manufacturing of medical devices and is now also suitable for pharmaceutical drug delivery applications and ensures firm control over the crucial parameters of the electrospinning process, leading to reproducible and consistent end-products.

About STENTiT

STENTiT is a medical device spin-off company from Dutch Eindhoven University of Technology, focusing on the development of regenerative endovascular implants. These devices trigger a natural healing response by the circulating blood cells, in which the implant is being rebuilt with new vascular tissue while safely dissolving over time.

Since the establishment of the company in 2017, STENTiT has received broad international recognition and awards for its high-potential approach, covering world leading stages. As the company is currently going through the next translational phases, STENTiT is on its way to fulfill its ambition to become the new standard in endovascular treatment, providing a life-lasting solution for millions of patients around the world.

For more info, please visit http://www.stentit.com

About IME Medical Electrospinning

For over ten years, IME Medical Electrospinning has been a leading player in the field of developing and implementing electrospinning processes and equipment for the manufacturing of medical devices for (regenerative) medicine and drug delivery. Electrospinning is a flexible process for producing extremely thin fibers and structures that have excellent properties to help regenerate human tissue. IME Medical Electrospinning has developed a unique set of innovations in electrospinning technology for the reproducible and scalable production of electrospun material under tightly controlled conditions required for the MedTech and Pharma market. Customers and scientific partners include the MedTech and Pharma industry, scientists and health institutions.

More information available atwww.ime-electrospinning.com

For further inquiries:

IME Medical Electrospinning, Waalre, The NetherlandsJudith Heikoop M.Sc. Ph.D.T: +31 40 28 27 956E: [emailprotected]

STENTiT, Eindhoven, The NetherlandsBart Sanders M.Sc. Ph.D.T: +31 40 24 72 445E: [emailprotected]

For media:

LifeSpring Life Sciences Communication, AmsterdamLon MelensT: +31 6 538 16 427E: [emailprotected]

Logo: https://mma.prnewswire.com/media/1248580/IME_Medical_Electrospinning_Logo.jpg

SOURCE IME Medical Electrospinning

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IME Medical Electrospinning and STENTiT enter into development cooperation on resorbable endovascular support grafts to regenerate vascular tissue -...

(Feb 2021 trend research report )The newly added report titledGlobal Regenerative Medicine Market Report 2020, Forecast to 2030to the database ofinsightSLICEreveals existing trends and tendencies in the industry. The report contains vital insights on the market and a thorough overview of the market where it identifies industry trends, determines industry insights, and offers competitive intelligence. The report helps to figure out and study the market needs, market size, and competition. The report includes noteworthy information alongside future conjecture and point by point market scanning on a worldwide, regional, and local level for the global Regenerative Medicine industry. The research document is designed with correctness and in-depth knowledge which helps the business to grow and henceforth results in revenue growth.

The report analyzes the current market trends, consumer demands, and preferences, market situations, opportunities, and market status. Other principles studied in terms of the market report include market definition, market segmentation, competitive analysis, and research methodology. The report offers an in-depth analysis of the global Regenerative Medicine markets historical data and estimated projections about the market size and share in the forecast period from 2020 to 2030. It also includes market trends, revenue growth patterns market shares, and demand and supply. The report is segmented on the basis of types, end-users, applications, and regional markets.

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Development policies and plans are discussed and manufacturing processes and industry chain structures are analyzed. This report also provides data on import / export, supply and consumption, as well as manufacturing costs and global revenues, and gross margin by region. The numerical data are copied with statistical tools, such as SWOT analysis, BCG matrix, SCOT analysis and PESTLE analysis. Statistics are presented in graphical form to provide a clear understanding of the facts and figures.

The main manufacturers covered in this report:

3M Group, Novartis AG and Integra Lifesciences Holdings Corporation.

Market segmentation:

The Regenerative Medicine market is divided into several essential sectors, including application, type and region . Each market segment is extensively studied in the report, taking into account market acceptance, value, demand and growth prospects. Segmentation analysis allows customers to customize their marketing approach to place better orders for each segment and identify the most potential customer base

Regional views of the market Regenerative Medicine

In terms of geography, this research report covers almost every major region in the world, such as North America, Europe, South America, the Middle East and Africa and Asia Pacific. Europe and North America are expected to increase in the coming years. The Asia Pacific Regenerative Medicine market is expected to grow significantly during the forecast period. The latest technologies and innovations are the most important features of North America and the main reason why the United States dominates the world market. The South American market for Regenerative Medicine is also expected to grow in the near future.

The report covers the impacts of COVID-19 on the market.

The ongoing pandemic has changed several facets of the market. This research report provides financial impacts and market disruption to the Regenerative Medicine market. It also includes analyzing potential opportunities and challenges in the foreseeable future. insightSLICEinterviewed several industry delegates and engaged in primary and secondary research to provide customers with information and strategies to address market challenges during and after the COVID-19 pandemic.

The main questions answered in the report:

The Industry Analysis market payroll online service assists customers with personalized and syndicated reports of significant importance to the experts involved in market analysis and data. The report also calls for market-oriented results that conduct a feasibility study for the customers needs. insightSLICEguarantees validated and verifiable aspects of market data operating in real time scenarios. Analytical studies are conducted to confirm customer needs with a complete understanding of market capabilities in real-time scenarios.

The conclusion of this report provides an overview of the potential for new projects to be successful in the market in the near future, and the global payroll online service market in terms of investment potential in various market sectors covers the full range .

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Regenerative Medicine Market 2020 Business Growth, Technology and Production Analysis, Opportunities and Regional Market Scope by 2030 KSU | The...

The increased incidence of chronic illnesses and genetic disorders and increased spending by governments are driving the demand for the market. Market Size USD 3.05 Billion in 2019, Market Growth - CAGR of 9.3%, Market Trends High demand for stem cell technology

This press release was orginally distributed by SBWire

Vancouver, BC -- (SBWIRE) -- 02/11/2021 -- Regenerative medicine can be defined as the category of medicine that delves into the replacement or regeneration of human tissues, cells, and organs for re-establishing the normal functionality of the body.

The treatment of specific indications and chronic conditions is expected to have significant effects on healthcare. Therefore, a high prevalence, combined with increasing global geriatric population and cancer, neurodegenerative, orthopedic and other aging-related disorders drive market growth. In addition, the increasing prevalence of genetic diseases inherited in the field of biotechnology is expected to increase demand.

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Regenerative Medicine Market Drivers

Factors that can be attributed to the growth in the market are a robust product pipeline in clinical trials and government and private funding. Many companies are investing in research and development to enhance their products with the latest technological advancements and comply with the unmet consumer needs.

Leading Key players in the market include Integra LifeSciences Corporation, Astellas Pharma Inc., Corline Biomedical AB, COOK BIOTECH, INC., Bayer BV, Abbott, AstraZeneca, F. Hoffmann-La Roche Ltd, Pfizer Inc., and Merck & Co., Inc., among others.

Companies are developing products for diabetes, neurological diseases, cancers, and cardiovascular disorders due to the rising number of these diseases. Diabetes and obesity may lead to an increase in the complexity of wounds like ulcerations on the legs or foot, infections, and surgical wounds, which require treatments and result in high costs.

For the purpose of this report, Emergen Research has segmented into the global Regenerative Medicine Market on the basis of Product, Therapeutic Category, Application, and region:

Product Outlook (Revenue: USD Billion; Volume: Million Tons; 2017-2027)TherapeuticsToolsBanksServices

Therapeutic Category Outlook (Revenue: USD Billion; Volume: Million Tons; 2017-2027)DermatologyMusculoskeletalImmunology & InflammationOncologyCardiovascularOphthalmologyOthers

Application Outlook (Revenue: USD Billion; Volume: Million Tons; 2017-2027)Musculoskeletal DisordersWound CareOncologyOcular DisordersDiabetes

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North America had the largest share of revenue of regenerative medicines in 2019 and its dominant position is expected to continue in the forthcoming period. A large number of universities and academic organizations are expected to fuel development by exploring various stem cell-based regenerative approaches.

Regional Landscape

On the basis of region, North America held the largest revenue share of the regenerative medicine market owing to the presence of a vast number of key players in the region. Also, the emergence of innovative technologies and the presence of many research institutes are factors responsible for driving the market's growth.

In market segmentation by geographical regions, the report has analysed the following regions-

North America (USA, Canada and Mexico)

Europe (Germany, France, UK, Russia and Italy)

Asia-Pacific (China, Japan, Korea, India and Southeast Asia)

South America (Brazil, Argentina, Columbia etc.)

Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

Asia-Pacific region is estimated to register the fastest growth in the near future, which can be attributed to the continuously improving infrastructure for enhancing healthcare research in many countries. Additionally, rapidly changing lifestyles, an increase in the aging population, and rising medical needs are some of the major factors responsible for driving the regenerative medicine market's growth.

Table of Content

Chapter 1. Methodology & Sources

1.1. Market Definition

1.2. Research Scope

1.3. Methodology

1.4. Research Sources

1.4.1. Primary

1.4.2. Secondary

1.4.3. Paid Sources

1.5. Market Estimation Technique

Chapter 2. Executive Summary

2.1. Summary Snapshot, 2019-2027

Chapter 3. Key Insights

Chapter 4. Regenerative Medicine Market Segmentation & Impact Analysis

4.1. Regenerative Medicine Market Material Segmentation Analysis

4.2. Industrial Outlook

4.2.1. Market indicators analysis

4.2.2. Market drivers analysis

4.2.2.1. Presence of strong pipeline portfolio and high number of clinical trials

4.2.2.2. Major milestones & key events in regenerative medicine

4.2.2.3. High economic impact of regenerative medicine

4.2.2.4. Emerging applications of gene therapy in regenerative medicine

4.2.3. Market restraints analysis

4.2.3.1. High cost of treatment

4.2.3.2. Industry Challenges

4.2.3.3. Regulatory issues regenerative medicine

4.3. Technological Insights

4.4. Regulatory Framework

4.5. Porter's Five Forces Analysis

4.6. Competitive Metric Space Analysis

4.7. Price trend Analysis

4.8. Covid-19 Impact Analysis

Chapter 5. Regenerative Medicine Market By Product Insights & Trends, Revenue (USD Billion)

5.1. Product Dynamics & Market Share, 2019 & 2027

5.1.1. Therapeutics

5.1.2. Tools

5.1.3. Banks

5.1.4. Services

Chapter 6. Regenerative Medicine Market By Therapeutic Category Insights & Trends Revenue (USD Billion)

6.1. Therapeutic Category Dynamics & Market Share, 2019 & 2027

6.1.1. Dermatology

6.1.2. Musculoskeletal

6.1.3. Immunology & Inflammation

6.1.4. Oncology

6.1.5. Cardiovascular

6.1.6. Ophthalmology

6.1.7. Others

Chapter 7. Regenerative Medicine Market By - Application Insights & Trends Revenue (USD Billion)

7.1. Application Dynamics & Market Share, 2019 & 2027

7.1.1. Musculoskeletal Disorders

7.1.2. Wound Care

7.1.3. Oncology

7.1.4. Ocular Disorders

7.1.5. Diabetes

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Regenerative Medicine Market Revenue, Statistics, Industry Growth and Demand Analysis Research Report by 2027 - Press Release - Digital Journal

TAMPA, Fla. The parents of a Florida boy battling cancer are asking for the publics help in finding a life-saving blood stem cell donor.

Jakobe "Kobe" Washington, 8, was diagnosed with leukemia in August. Hes receiving treatment at All Childrens Hospital in St. Petersburg.

"Its tough to see your kid fighting a fight, and you cant do anything but be there to support him, no control in it at all," said his father Jordan Washington.

With chemotherapy not working, Kobes family says he is now in desperate need of a blood stem cell transplant.

"For Jakobe, his life depends on it," said his mother Imeria Price.

According to Be The Match, the national marrow donor program, Black patients are the least likely to find a matching donor when battling blood cancers like leukemia and lymphoma.

"Finding a matching donor is difficult, and of the 22 million potential donors on the Be The Match Registry, there are no ideal matches for Kobe," said Erica Sevilla. "This is partially because ancestry matters in finding a match and African Americans only make up 4% of the registry. The end result: Less than 1 in 4 Black patients find a match compared to 3 in 4 White patients."

Be The Match held a COVID-safe, drive-thru cheek swabbing event Friday. Dozens of people showed up to see if they may be a match. A second event will be held on Saturday from 9 a.m. to 2 p.m. at WestShore Plaza in Tampa.

Individuals who cannot make the swabbing event can join the registry by texting KOBE to 61474 and a cheek swab kit will be mailed to their home.

"I have a bright future planned ahead of me, Kobe said Thursday from a hospital bed in St. Pete. I just need your help to get through this and Im going to keep fighting."

Be The Match is hoping to find donors between the ages of 18 and 44, which they say has the highest success rate for donations.

Jessie McNeil hopes he can be a match for Kobe, or anyone else on the waiting list. God has given me a blessed life and a fortunate life so I would love for Kobe to be able to experience life as well, he said.

Bekin Burkinshaw also got his cheeks swapped to see if he could help. Theres 22 million people in the database and not a single match for Kobe which is kind of an unbelievable statistic to think is real, so I think its important to try to give him that one person who could help him out and save his life, added.

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Florida boy battling cancer in need of blood stem cell donor - ABC Action News