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Archive for the ‘Stem Cell Russia’ Category

Europe Mesenchymal Stem Cells Market Forecast 2022 Study covering Strategies, Application, Growth Estimation and … – satPRnews (press release)

Thursday, August 17th, 2017

A new research document with title Europe Mesenchymal Stem Cells Market by Manufacturers, Countries, Type and Application, Forecast to 2022 covering detailed analysis, Competitive landscape, forecast and strategies. The study covers geographic analysis that includes regions like Germany, UK, France, Russia, Italy and important players/vendors such as Thermo Fisher, Bio-Techne, ATCC, etc The report will help user gain market insights, future trends and growth prospects for forecast period of 2017-2022

Request a sample report @ https://www.htfmarketreport.com/sample-report/643003-europe-mesenchymal-stem-cells-marketMesenchymal Stem Cells (MSC), also termed Mesenchymal Stromal Cells, are multipotent cells that can differentiate into a variety of cell types and have the capacity for self-renewal.

Scope of the Report:

This report focuses on the Mesenchymal Stem Cells in Europe market, especially in Germany, UK, France, Russia, and Italy. This report categorizes the market based on manufacturers, countries, type and application.

Market Segment by Manufacturers, this report covers

Lonza

Thermo Fisher

Bio-Techne

ATCC

MilliporeSigma

PromoCell GmbH

Genlantis

Celprogen

Cell Applications

Cyagen Biosciences

Axol Bioscience

Market Segment by Countries, covering

Germany

UK

France

Russia

Italy

Market Segment by Type, covers

Human MSC

Mouse MSC

Rat MSC

Other

Market Segment by Applications, can be divided into

Research Institute

Hospital

Others

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There are 17 Chapters to deeply display the Europe Mesenchymal Stem Cells market.

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Chapter 2, to analyze the manufacturers of Mesenchymal Stem Cells, with profile, main business, news, sales, price, revenue and market share in 2016 and 2017;

Chapter 3, to display the competitive situation among the top manufacturers in Europe, with sales, revenue and market share in 2016 and 2017;

Chapter 4, to show the Europe market by countries, covering Germany, UK, France, Italy and Russia, with sales, price, revenue and market share of Mesenchymal Stem Cells, for each country, from 2012 to 2017;

Chapter 5 and 6, to show the market by type and application, with sales, price, revenue, market share and growth rate by type and application, from 2012 to 2017;

Chapter 7, 8, 9, 10 and 11, to analyze the key countries by manufacturers, Type and Application, covering Germany, UK, France, Italy and Russia, with sales, revenue and market share by manufacturers, types and applications;

Chapter 12, Mesenchymal Stem Cells market forecast, by countries, type and application, with sales, price, revenue and growth rate forecast, from 2017 to 2022;

Chapter 13, to analyze the manufacturing cost, key raw materials and manufacturing process etc.

Chapter 14, to analyze the industrial chain, sourcing strategy and downstream end users (buyers);

Chapter 15, to describe Mesenchymal Stem Cells sales channel, distributors, traders, dealers etc.

Chapter 16 and 17, to describe Mesenchymal Stem Cells Research Findings and Conclusion, Appendix, methodology and data source

.Continued

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China Regenerative’s Stem Cell Research Sparks Hope – Bloomberg

Saturday, August 5th, 2017

Bloomberg
China Regenerative's Stem Cell Research Sparks Hope
Bloomberg
Stem cells can become just about any sort of tissue, if cultivated correctly. With so many potential applications, the companies that perfect the use of stem cells first will stake a claim on massive profits. Hong Kong's China Regenerative Medicine is ...

and more »

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China Regenerative's Stem Cell Research Sparks Hope - Bloomberg

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A Warning About ‘Stem Cell Tourism’ – Multiple Sclerosis News Today

Friday, August 4th, 2017

I regularly see comments on various social media sites from MS patients who have traveled, or who plan to travel, outside the U.S. to be treated with stem cells. Some of these patients have reported excellent results and a reversal of symptoms. Others have died. Many MS patients are frustrated with the slow stem-cell approval process in the U.S.

I wrote about this slow process in February, but just the other day someone commented on that old column, and said she was heading to Russia soon for a stem cell transplant:

They started studying it in Chicago more than 20 years ago, it is ridiculous that is still has not been approved! Boy, they keep on approving those high priced drugs that dont work and can kill you! I have been studying this and waiting for 17 years for approval in the states. I cant wait any longer, I am heading to Moscow in February to receive the treatment that I need!

But an article that recently appeared in the journal Science Translational Medicine strongly warns against this sort of thing, and what the authors call the marketing of unproven stem cell-based interventions.

Those authors are 15 scientists from seven countries. One of them is Sarah Chan of the University of Edinburgh. Quoted in a university press release, her remarks sound as if they could be directed to the MS patient who is heading to Moscow:

Many patients feel that potential cures are being held back by red tape and lengthy approval processes. Although this can be frustrating, these procedures are there to protect patients from undergoing needless treatments that could put their lives at risk.

The scientists concerns are about stem cell therapies for many diseases, not just those that are used as MS treatments. The authors call the practice of advertising therapies that arent supported by clinical research, and that are often made directly to patients, stem cell tourism.

Chan and her colleagues are calling for the World Health Organization to offer guidance on what should be considered responsible clinical use of cells and tissues, just as the WHO does for medicines and medical devices.

Stem cell therapies hold a lot of promise, Chan writes, but we need rigorous clinical trials and regulatory processes to determine whether a proposed treatment is safe, effective and better than existing treatments.

Rather than rushing through stem cell approval in the U.S., the authors call for tighter regulations on stem cell therapy advertising, especially regarding potential clinical benefits. They also think that international regulatory standards should be established for the manufacture and testing of human cell and tissue-based therapies.

Thats all well and good, but where does that leave the MS patients who need this treatment now, not five or 10 years from now? What do they say to the woman whos been waiting for 17 years and can wait no longer, so shes headed to Russia? How many more months or years of clinical trials are needed before stem cell therapies will be considered safe, effective and better than existing treatments in the United States?

Just askin.

(Youre invited to follow my personal blog at http://www.themswire.com)

***

Note:Multiple Sclerosis News Todayis strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The opinions expressed in this column are not those ofMultiple Sclerosis News Today, or its parent company, BioNews Services, and are intended to spark discussion about issues pertaining to multiple sclerosis.

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A Warning About 'Stem Cell Tourism' - Multiple Sclerosis News Today

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Longford Lives: From Granard to Russia in the fight against MS – Longford Leader

Friday, August 4th, 2017

'Fear has two meanings; forget everything and run OR face everything and rise - the choice is yours.

The latter half of this saying applies to Granard native Stephen Garland (45) who was diagnosed with Multiple Sclerosis (MS) back in 2015.

He had been ill for five years before finally getting to the crux of of the matter and is now fundraising with gusto so that he can access specialised treatment in Russia.

Although its 25 years since he left Ireland and set down roots in Spain and Brazil, in recent times he moved back home and now resides in Longford town with his wife Valeska Magalhes.

He played football for Granard and was president of Barcelona Gaels for five years.

Stephen has set up an online campaign - To Russia with Love and is set to bring comedy charity gigs to a whole new level over the coming months.

An events manager by trade, the Granard man has worked as a comedy and music promoter for the last 20 years, and has gotten to know many of the big names in the comedy business.

Therefore its not surprising to learn that the much loved funny man Jason Byrne has lent his support to the To Russia with Love campaign.

Byrne is now set to headline a charity fundraiser at the Longford Arms Hotel on Saturday, September 23 next.

And as Stephen pointed out, the rest of the bill is beginning to take shape and all details will appear on my page as soon as they are known.

The night is expected to include a host of other comedy personalities and there are lots of surprises in store!

Jason Byrne was one of the first acts the Granard man ever brought to Spain to help him launch professional comedy in the region.

That was 2004 and the industry has come a long way in the intervening 13 or so years.

When I let Jason know about my condition he said he would help in any way he could, added Stephen who was diagnosed just over two years ago now.

I was in a meeting with the highly regarded neurologist Professor Xavi Montalban, of CEMCAT a fantastic MS specialised institution in Barcelona, he said, recalling the day with clarity.

Unimpressed with his MRI quality at that point, Stephen engaged in further tests in the months thereafter and in June 2016 he was diagnosed with the PPMS strain of MS which is regarded as the least common type with no cure or treatment available. He says there are four types of MS including Relapsing-Remitting MS (RRMS); Secondary-Progressive MS (SPMS); Primary-Progressive MS (PPMS); Progressive-Relapsing MS (PRMS).

After an exhausting four year search for a diagnosis that has taken me thousands of kilometres within Brazil; across an ocean; back home to Ireland and then subsequently on to my other European home, Barcelona, there was relief to know what was wrong with me, finally, the son of Gerry and Roseanne added.

Stephen is also the brother of well- known Longford town businessman David.

And so now, the next step for the Granard native is Russia.

I first came across the AA Maximov Hematology and Cell Therapy Department of the National Pirogov Medical Surgical Centre which specialises in the state-of-the-art treatment of hematological, oncological and autoimmune diseases, via an editorial in the Cavan Celt newspaper, said Stephen.

This article told the story of a young man from Castleblayney in Co Monaghan - Darren Gibson - who had just recently being diagnosed with MS - RRMS the Relapsing, Remitting type and he was intent on going to Russia for Hematopoietic Stem Cell Transplant (HSCT).

He was seeking to raise funds, so I touched base with him and we subsequently got to know each other.

Darren as the true pioneer and the first Irish person to go to Russia has been an invaluable source of help and inspiration to me.

To date nearly 10,000 has been raised for Stephens treatment in Russia with the stakes rising by the day for much more!The target is 70,000.

Stephen says it is imperative that he gets to Russia.

While I am cognitively sound at the moment, this could all change, so this is why I need to get to Russia, he continued, before pointing out that while MS was a terrible disease, his life was moving forward nonetheless.

I need to retrain now and Im undertaking a Degree course in web development over the coming months.

I had a goal of raising 70,000 - a figure I have arrived at from several people who have made the exact same journey I am proposing, he continued before pointing out the figure represented flights and visa expenses at 5,000; HSCT, 50,000; post haematologist care, 5,000.

He says the treatment will not cure the MS but what it will do is stop it from progressing.

I am staying positive and keeping myself busy organising fundraisers so I can raise the money to get to Russia, he explained.

Stephen will also be part of the 70th anniversary of the Edinburgh Fringe Festival in August where his play The Pre-Disposed will play eight nights at the Banshee Labyrinth Banqueting Hall in Edinburgh.

It will run from August 12-19 from 21:50-22:50 and centers around his own story told through three 10 minute segments with video clips included for effect.

Fundraisers to date include the Barcelona Comedy Festival Fundraiser Weekender; Granard GAA St Stephen's Day Walk and Fays Bar Christmas Prize Draw.

Im a positive guy, he adds.

My focus now is on getting to Russia for this treatment. To donate to this very worthy cause or to find out more about Stephen Garland and his campaign log onto http://www.stopmyppms.com

Donations can also be made at http://www.gofundme.com/StopGarlandsPPMS.

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Longford Lives: From Granard to Russia in the fight against MS - Longford Leader

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Experts call for global action on unproven stem cell therapies – BioNews

Tuesday, July 11th, 2017

International experts are calling for global action on unproven and potentially dangerous stem cell therapies, and their misleading marketing to the public.

'Many patients feel that potential cures are being held back by red tape and lengthy approval processes. Although this can be frustrating, these procedures are there to protect patients from undergoing needless treatments that could put their lives at risk,' said Dr Sarah Chan from the University of Edinburgh. She is one of 15 authors who published the clarion call in the journal Science Translational Medicine.

Currently only few conditions can be successfully treated with stem cells, including blood cancers, some immune diseases, and severe burns.

Despite this, unlicensed clinics advertise stem cell-based treatments directly to patients promising a cure for various ailments when there is no evidence to show they will help, or that they will not cause harm.

The internet and social media have helped the burgeoning direct-to-consumer marketing of both licensed and unlicensed stem cell therapies, and 'offers sellers the ability to reach worldwide audiences, amplifying the difficulties of enforcing national laws in a global marketplace', note the authors.

They add that patients are vulnerable to these online marketing strategies due to the hyped media coverage of stem cell research; a lack of reliable information; and a combination of missing international guidelines and conflicting national regulations on procedures.

Foregoing alternative therapies, patients take risks on invalid stem cell-based procedures, which have led to deaths in Australia, Russia and Germany, warn the authors. While those who sell the treatments may be difficult to hold accountable due to legal grey areas on stem cell-based treatments in most countries.

In addition to the potential harm to patients, 'unfulfilled promises may bring regenerative medicine research and development into disrepute' the authors caution.

In their call for action, the experts from UK, the USA, Canada, Belgium, Italy and Japan urge for a cooperation of national and international efforts to control the global industry of stem cell-based medical procedures and their advertising.

The authors believe that 'predatory' clinics can be exposed on a national level, when scientific experts, investigative journalists and local authorities work together, such as in a recent trial of the Stamina Foundation in Italy, a highly publicized provider of unproven stem cell treatments (see BioNews 878).

They further suggest controls on advertising and international standards for the manufacture and testing of cell and tissue-based therapies, similar to global drug quality standards, which might be set by the World Health Organisation.

Such measures will only be effective when national governing bodies cooperate to ensure compliance, but the experts warn that 'the stakes are too high not to take a united stance'.

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Christchurch MS patient Andrea Cameron-Hill plans Russia trip for stem cell treatment – The Press

Tuesday, July 11th, 2017

JOEL INESON

Last updated14:01, July 9 2017

IAIN MCGREGOR/Stuff.co.nz

Andrea Cameron-Hill has lived with multiple sclerosis for about 10 years. She wants to receive treatment in Russia that could stop the disease.

Andrea Cameron-Hill thought having to lift her leg to get in the carwhile pregnant was part of carrying twins.

About 10 weeks after they were born she learned she had multiple sclerosis (MS).

"To start with, you wouldn't know I had MS at all. But now it's 10 years on and I'm having to walk with a crutch," she said.

IAIN MCGREGOR/STUFF

MS sufferer Cameron-Hill wants to receive treatment that could stop the disease in its tracks but, despite it being offered here to treat some cancer, must travel to Russia to get it.

"If I have to go down to the floor to load the fire with wood, the difficulty for me now is getting off the floor."

READ MORE: *Multiple sclerosis sufferer Royce Brewer cleared after experimental treatment in Russia *Multiple sclerosis patient to receive 'experimental' treatment in Russia *Friends rallying to help Upper Hutt woman reach Mexico for stem cell treatment *Marlborough woman's search for cure *Plea to help fund stem-cell treatment for Andrea Campbell *Hunt after cure for MS disease

Cameron-Hill has injured her shoulder fromfalls and reliedon her husband, Paul, and sons Lachlanand Oliverto help with household chores.

IAIN MCGREGOR/STUFF

Normal household chores like washing are a challenge because of the debilitating condition.

She wanted to do things like go onto the rugby field while her childrenplayed, but MS meant she had to watch from the car.

"We've got a basketball hoop [at home], which they quite like playing, but they normally play with Grandma because I can't."

"I feel like a spectator in their lives. I hate it. I hate it with a passion."

IAIN MCGREGOR/STUFF

Cameron-Hill's sons, Lachlan and Oliver, pictured, help her complete tasks many do effortlessly.

Cameron-Hill's condition drove herto look at a treatmentused in New Zealand for some forms of cancer, but not available for MS.

She plans to head to Russia for undergohematopoieticstem cell transplantation (HSCT).

HSCT would remove, purifyand concentrate her stem cells.Chemotherapy would wipeher immune system before the stem cells were returned. An extended period of recovery would follow.

IAIN MCGREGOR/STUFF

Cameron-Hill wants to take part in her children's lives, rather than watch from the sidelines.

Cameron-Hill mustraise about $80,000 to get the treatment.So far about $10,000 has been raised through fundraising events and aGivealittlepage.

Leading New Zealand neurologist Dr Deborah Mason said HSCT wasunlikely to be trialledin New Zealand because it wouldnot make drug companies money.

Treatment for MSin New Zealandreliesonimmunosuppressantdrugs.HSCTwaslikened more to a surgical procedure than drug treatment.

"It's incredibly expensive ... We're very keen to participate in [trials and research] and I'd certainly enroll patients, but it's just finding somebody who would fund that, and nobody will because there's no drug involved," Mason said.

Mason saidHSCT might help young patients in the early stages of MS.

She said the treatment was "unproven" and came with risks.

"It's really hard to imagine why I get all these calls about bone marrow transplants ... all bone marrow transplant allows us to [do is] give industrial doses of chemotherapy."

"People talk aboutrebootingthe immune system and all of that. There isn't a lot of proof of that."

Mason knew of about six or seven people who had travelled forHSCT, but did not have a lot of follow-updata.

Studies and clinical trials New Zealanders took part in primarily focussed on medication.

Her "big beef" was with the government not allowing the use of some drugs, "which we absolutely know will benefit the patients".

The Multiple Sclerosis Society of New Zealand recently changed its standpoint on HSCTafter a report indicated the treatment workedfor some with MS in Australia and the UK.

Vice president Neil Woodhams said the group asked the Ministry of Health to start a process to lead to eligible people havingHSCTin New Zealand.

Cameron-Hill's MS had not progressed since 2013and she had not been on medication for it since.

She recently met Christchurch manRoyce Brewer who lived with MS for about 20 years. After undergoing HSCT in Russia in early 2016, hereturned to work as a landscaper at the end of the year.

"I'd just really love to be able to do ... normal stuff that parents do with their kids," Cameron-Hill said.

The Health Research Council of New Zealandhad not funded any research regarding MS andHSCT, a spokeswoman said.

-Stuff

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Trump supporters know Trump lies. They just don’t care. – Vox

Tuesday, July 11th, 2017

During the campaign and into his presidency Donald Trump repeatedly exaggerated and distorted crime statistics. Decades of progress made in bringing down crime are now being reversed, he asserted in his dark speech at the Republican National Convention in July 2016. But the data here is unambiguous: FBI statistics show crime has been going down for decades.

CNNs Jake Tapper confronted Trumps then-campaign manager, Paul Manafort, right before the speech. How can the Republicans make the argument that somehow its more dangerous today, when the facts dont back that up? Tapper asked.

People dont feel safe in their neighborhoods, Manafort responded, and then dismissed the FBI as a credible source of data.

This type of exchange where a journalist fact-checks a powerful figure is an essential task of the news media. And for a long time, political scientists and psychologists have wondered: Do these fact checks matter in the minds of viewers, particularly those whose candidate is distorting the truth? Simple question. Not-so-simple answer.

In the past, the research has found that not only do facts fail to sway minds, but they can sometimes produce whats known as a backfire effect, leaving people even more stubborn and sure of their preexisting belief.

But theres new evidence on this question thats a bit more hopeful. It finds backfiring is rarer than originally thought and that fact-checks can make an impression on even the most ardent of Trump supporters.

But theres still a big problem: Trump supporters know their candidate lies, but that doesnt change how they feel about him. Which prompts a scary thought: Is this just a Trump phenomenon? Or can any charismatic politician get away with being called out on lies?

In 2010, political scientists Brendan Nyhan and Jason Reifler published one of the most talked about (and most pessimistic) findings in all of political psychology.

The study, conducted in the fall of 2005, split 130 participants into groups who read different versions of a news article about President George W. Bush defending his rationale for engaging in the Iraq War. One version merely summarized Bushs rationale There was a risk, a real risk, that Saddam Hussein would pass weapons or materials or information to terrorist networks. Another version of the article offered a correction that, no, there was not any evidence Saddam Hussein was stockpiling weapons of mass destruction.

The results were stunning: Staunch conservatives who saw the correction became more likely to believe Hussein had weapons of mass destruction. (In another experiment, the study found a backfire on a question about tax cuts. On other questions, like on stem cell research, there was no backfire.)

Backfire is a pretty radical claim if you think about it, Ethan Porter, a political scientist at George Washington University, says. Not only do attempts to correct information not sink in, but they can actually make conflicts even more intractable. It means earnest attempts to educate the public may actually making things worse. So in 2015, Porter and a colleague, Thomas Wood at the Ohio State University, set out to try to replicate the effect for a paper (which is currently undergoing peer review for publishing in the journal Political Behavior).

And among 8,100 participants and on the sort of political questions that tend to bring out hardline opinions Porter and Wood hardly found any evidence of backfire. (The one exception, interestingly, was the question of weapons of mass destruction in Iraq. But even on that, the backfire effect went away when they tweaked the wording of the question.)

Theres no evidence that backfire describes a common reflex of Americans when it comes to facts, Porter assures me. (Nyhan, for his part, never asserted that backfire was ubiquitous, just that it was a possible and particularly consequential result of fact-checking.)

Stories of failed replications in social psychology often grow ugly, with accusations of bullying and scientific misconduct flying in both directions. But in this story, researchers decided to team up to test the idea again.

The fact that Nyhan and Reiflers breakthrough study didnt replicate isnt a shocker. This happens all the time in science. One group of researchers publishes a breakthrough finding. Another lab tries to replicate it, and fails.

But instead of feuding, Nyhan, Reifler, Porter, and Wood came together to conduct a new study.

If you believe in social science, this is an ideal way to resolve a dispute, Porter says. If we can devise an experiment together, then the results are going to have something meaningful to say about our differing understandings of the world.

So the four researchers collaborated on two experiments with a wide range of people as subjects, including Trump and Hillary Clinton supporters.

The first experiment drew on Trumps exaggerations of crime statistics.

In the experiment, participants read one of five news articles. One was a control article about bird watching. Another just contained a summary of Trumps message without a correction. The third was an article that included a correction. The fourth included a correction, but then also a line of pushback from onetime Trump campaign manager Paul Manafort, who said the FBIs statistics were not to be trusted. The fifth included a line where Manafort really laid into the FBI, saying, "The FBI is certainly suspect these days after what they just did with Hillary Clinton.

The thinking here: If anyone should be able to incite a backfire effect among Trump supporters, its Trumps campaign director. Manafort gives Trump supporters cover. They can reject the correction and cite one of the most influential figures in the campaign. And if theres a time backfire ought to occur, its during a presidential campaign, when our political identities are fully activated.

But it didnt happen. On average, all the studys participants were more likely to accept the correction when they read it. Trump supporters were more hesitant to accept it than Clinton supporters. But thats not backfire; thats reluctance. Manaforts assertion that the FBI statistics were not to be trusted didnt make much of a difference either.

Everyones beliefs about changing crime over the last 10 years became more accurate in the face of a correction, Nyhan says.

The research group then conducted a second experiment during the presidential debates. This one was conducted in near-real time: On the night of the first presidential debate, the group ran an online study with 1,500-plus participants.

The study focused on one Trump claim in particular. Trump said thousands of jobs [are] leaving Michigan, Ohio ... theyre just gone.

This, again, isnt true. The Bureau of Labor Statistics actually finds both states created 70,000 new jobs in the previous year. Half of the participants saw the correction; the other half did not.

Again, the researchers found no evidence of backfire. Its worth underscoring: This was on the night of the first presidential debate. Its the Super Bowl of presidential politics. If corrections arent going to backfire during a debate, when will they?

In both experiments, the researchers couldnt find instance of backfire. Instead, they found that corrections did what they were intended to do: nudge people toward the truth. Trump supporters were more resistant to the nudge, but they were nudged all the same.

But heres the kicker: The corrections didnt change their feelings about Trump (when participants in the corrections conditions were compared with controls).

People were willing to say Trump was wrong, but it didnt have much of an effect on what they felt about him, Nyhan says.

So facts make an impression. They just dont matter for our decision-making, which is a conclusion thats abundant in psychology science.

(And if youre thinking, How could one short experimental manipulation really change how much participants like Trump? know that other research shows its possible. Notably, studies conducted during the election found that just reminding white voters they may be a racial minority one day increased support for Trump.)

The big question is: To what extent do those results generalize beyond Trump himself? says Nyhan. Many of his supporters may have to come to terms with his records of misstatements by the time this study was conducted. (The researchers did not test any fact-checks of Hillary Clinton talking points.)

Nyhan doesnt place blame on Trump supporters themselves; its just human nature to stand by our political partys candidates. But he says theres something wrong with our institutions, norms, and party leaders who enable the rise of candidates who constantly lie.

At least its nice to know that facts do make an impression, right? On the other hand, we tend to avoid confronting facts that run hostile to our political allegiances. Getting partisans to confront facts might be easy in the context of an online experiment. Its much harder to do in the real world.

These results have not yet been peer-reviewed or published in an academic journal so treat them as preliminary. But I did run them by several political science and psychology researchers for a sniff test.

These two experiments are well done, and the data analysis appears to straightforward and correct: we observe clear movement on subjects beliefs as a result of factual corrections, Alex Coppock, who researches political decision-making at Yale, writes in an email. This piece is nice because it adds to the (small but growing) consensus that backfire effects, if they exist at all, are rare.

Others commended the researchers for collaborating in the face of conflicting results. I think this is exactly how the scientific process should operate as we try to explain human behavior, Asheley Landrum, who researches politically motivated reasoning at Texas Tech, writes. Social scientists, arguably, should be even more aware of motivated reasoning, recognizing that it also occurs in scientists.

Nyhans research is about seeing if attitude change is possible. And this research often comes to frustrating ends. In one study, he and Reifler tested out four different interventions to try to nudge vaccine skeptics away from their beliefs. None made a difference. Though it is elusive, at the least, he found a little attitude change within himself.

Jason [Reifler] and I have definitely updated our beliefs about the prevalence of the backfire effect, Nyhan says. He wont say its been debunked. But hes moving in that direction.

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Trump supporters know Trump lies. They just don't care. - Vox

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Takeda positioning itself to assume EU stem cell production within 5 years – FiercePharma

Monday, July 3rd, 2017

Takeda Pharma is positioning itself to take over stem cell production in Europe from its partner TiGenix by 2021 after Swissmedicthe Swiss Agency for Therapeutic Productssaid last weekit has accepted for review the file for an investigational drug to treat patients with Crohns disease.

The compound, which is dubbed Cx601, was granted orphan status by Swissmedic last year and is currently up for review by the European Medicines Agency to treat complex perianal fistulas in Crohns patients. Its highly anticipated Cx601 will get approved by the EU later this year.

The drug is currently being produced by Tigenix at its Madrid facility.

After a transition period for technology transfer, during which TiGenix will manufacture Cx601, Takeda will assume responsibility for manufacturing the compound, Luke Willats, a Takeda spokesman, told Fierce. We are currently exploring how Takeda can best meet this responsibility following a potential European Commission (EC) approval decision for the compound in 2017.

Willats did not say if Cx601 would continue to be produced in Madrid or at one of the Japanese pharmas production facilities located in Austria, Belgium, Denmark, Estonia, Germany, Ireland, Italy, Norway, Poland and Russia.

TiGenix currently has U.S. rights to the compound, and has said it is in discussions with the FDA to work toward garnering marketing approval.

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Takeda positioning itself to assume EU stem cell production within 5 years - FiercePharma

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Siberian scientists say stem cells can treat varicose veins – Russia Beyond the Headlines

Monday, July 3rd, 2017

Scientists at the Institute of Chemical Biology and Fundamental Medicine (ICBFM) based in Siberia have discovered that stem cells can restore blood flow in veins with clots.

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"Quite a lot of pathologies regarding veins still remain unstudied." Source: Getty Images

To help treat varicose veins, scientists need to accelerate the growth of blood vessels, which would be a crucial development for cardiac medicine. A heart attack is caused by damaged arteries, and an ischemic stroke also often results from vascular damage.

"Quite a lot of pathologies regarding veins still remain unstudied," said Igor Mayborodin, a doctor of medical sciences at the stem cell laboratory at ICBFM. "Weve looked into blood flow restoration in situations when there are blood clots. Now were trying to use stem cells to stimulate the growth of veins and bypass the diseased area."

The discovery by Siberian scientists will make it possible to successfully treat diseases of the veins and resulting complications, for example, varicosis, phlebothrombosis (the formation of a blood clot in the vein that leads to its blockage), and even some types of trophic ulcers and cerebral strokes.

Researchers conducted a number of studies on rats, injecting them with stem cells taken from their relatives. The experiment showed that within a week small vessels had formed in the rodents, and in the third week the replacement of the introduced cells with the rodents' own cells began.

The new blood vessels remained in the body but stem cells that formed walls were gradually replaced by those of the rodents. Thus, scientists showed that stem cells can restore blood flow, bypassing damaged veins. Based on the results, a series of articles will be prepared.

Also, scientists witnessed unexpected side effects. "Some of the stem cells die, and then macrophages are attracted to the site, that is, 'ingester' cells capable of actively engulfing and digesting the remains of dead cells," Mayborodin said. "This is what helps a surgical wound be rid of damaged tissue quicker and heal. This is a good result."

The scientists are continuing their state-funded research, and they have obtained a patent for their work. For the time being, however, they cant check the results in clinical tests because Russian law restricts the use of stem cells on humans.

"Wed like to utilize the obtained data in regards to humans, but this is currently not possible," Mayborodin said. "For now were refining the results of the research on cell therapy and clarifying possible complications. But wed like to test our hypothesis at least on a severe case of varicosis in clinical conditions."

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Siberian scientists say stem cells can treat varicose veins - Russia Beyond the Headlines

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HIV/AIDS research – Wikipedia

Thursday, December 8th, 2016

HIV/AIDS research includes all medical research that attempts to prevent, treat, or cure HIV/AIDS, as well as fundamental research about the nature of HIV as an infectious agent and AIDS as the disease caused by HIV.

Examples of particular HIV/AIDS research include, drug development, HIV vaccines, pre-exposure prophylaxis, or post-exposure prophylaxis.[1]

A body of scientific evidence has shown that men who are circumcised are less likely to contract HIV than men who are uncircumcized.[2] Research published in 2014, concludes that the sex hormones estrogen and progesterone selectively impact HIV transmission.[3]

"Pre-exposure prophylaxis" refers to the practice of taking some drugs before being exposed to HIV infection, and having a decreased chance of contracting HIV as a result of taking that drug. Post-exposure prophylaxis refers to taking some drugs quickly after being exposed to HIV, while the virus is in a person's body but before the virus has established itself. In both cases, the drugs would be the same as those used to treat persons with HIV, and the intent of taking the drugs would be to eradicate the virus before the person becomes irreversibly infected.

Post-exposure prophylaxis is recommended in anticipated cases of HIV exposure, such as if a nurse somehow has blood-to-blood contact with a patient in the course of work, or if someone without HIV requests the drugs immediately after having unprotected sex with a person who might have HIV. Pre-exposure prophylaxis is sometimes an option for HIV-negative persons who feel that they are at increased risk of HIV infection, such as an HIV-negative person in a serodiscordant relationship with an HIV-positive partner.

Current research in these agents include drug development, efficacy testing, and practice recommendations for using drugs for HIV prevention.

The within-host dynamics of HIV infection include the spread of the virus in vivo, the establishment of latency, the effects of immune response on the virus, etc.[4][5] Early studies used simple models and only considered the cell-free spreading of HIV, in which virus particles bud from an infected T cell, enter the blood/extracellular fluid, and then infect another T cell.[5] A 2015 study[4] proposes a more realistic model of HIV dynamics that also incorporates the viral cell-to-cell spreading mechanism, where the virus is directly transited from one cell to another, as well as the T cell activation, the cellular immune response, and the immune exhaustion as the infection progresses.[4]

A 2014 study with SIV found that the virus initially establishes a reservoir in the gut. The virus infection provokes an inflammatory response of paneth cells in the intestine, helping to spread the virus by causing tissue damage. The findings offer new pointers for potential future treatments, testing (biomarkers), and help to explain the virus resistance to antiviral therapies. The study also identified the bacteria strain Lactobacillus plantarum, which reversed damage by rapidly reducing IL-1 (Interleukin-1 beta).[6] Seeding of HIV in the body begins within a few days, during the acute phase of HIV infection.[7]

Research to improve current treatments includes decreasing side effects of current drugs, further simplifying drug regimens to improve adherence, and determining better sequences of regimens to manage drug resistance. There are variations in the health community in recommendations on what treatment doctors should recommend for people with HIV. One question, for example, is determining when a doctor should recommend that a patient take antiretroviral drugs and what drugs a doctor may recommend. This field also includes the development of antiretroviral drugs.

Infection with the Human Immunodeficiency Virus-1 (HIV) is associated with clinical symptoms of accelerated aging, as evidenced by increased incidence and diversity of age-related illnesses at relatively young ages. A significant age acceleration effect could be detected in brain (7.4 years) and blood (5.2 years) tissue due to HIV-1 infection [8] with the help of a biomarker of aging, which is known as epigenetic clock.

A long-term nonprogressor is a person who is infected with HIV, but whose body, for whatever reason, naturally controls the virus so that the infection does not progress to the AIDS stage. Such persons are of great interest to researchers, who feel that a study of their physiologies could provide a deeper understanding of the virus and disease.

An HIV vaccine is a vaccine that would be given to a person who does not have HIV, in order to confer protection against subsequent exposures to HIV, thus reducing the likelihood that the person would become infected by HIV. Currently, no effective HIV vaccine exists. Various HIV vaccines have been tested in clinical trials almost since the discovery of HIV.

Only a vaccine is thought to be able to halt the pandemic. This is because a vaccine would cost less, thus being affordable for developing countries, and would not require daily treatment.[9] However, after over 20 years of research, HIV-1 remains a difficult target for a vaccine.[9][10]

In 2003 a clinical trial in Thailand tested an HIV vaccine called RV 144. In 2009, the researchers reported that this vaccine showed some efficacy in protecting recipients from HIV infection. Results of this trial give the first supporting evidence of any vaccine being effective in lowering the risk of contracting HIV. Another possible vaccine comes from a novel gene therapy that alters the CCR5 co-receptor permanently, preventing HIV from entering cells.[11] Other vaccine trials continue worldwide.

A microbicide for sexually transmitted diseases is a gel which would be applied to the skin - perhaps a rectal microbicide for persons who engage in anal sex or a vaginal microbicide for persons who engage in vaginal sex - and if infected body fluid such as blood or semen were to touch the gel, then HIV in that fluid would be destroyed and the people having sex would be less likely to spread infection between themselves.

On March 7, 2013, the Washington University in St. Louis website published a report by Julia Evangelou Strait, in which it was reported that ongoing nanoparticle research showed that nanoparticles loaded with various compounds could be used to target infectious agents whilst leaving healthy cells unaffected. In the study detailed by this report, it was found that nanoparticles loaded with Mellitin, a compound found in Bee venom, could deliver the agent to the HIV, causing the breakdown of the outer protein envelope of the virus. This, they say, could lead to the production of a vaginal gel which could help prevent infection by disabling the virus.[12] Dr Joshua Hood goes on to explain that beyond preventative measures in the form of a topical gel, he sees "potential for using nanoparticles with melittin as therapy for existing HIV infections, especially those that are drug-resistant. The nanoparticles could be injected intravenously and, in theory, would be able to clear HIV from the blood stream."[12]

In 2007, Timothy Ray Brown,[13] a 40-year-old HIV-positive man, also known as "the Berlin Patient", was given a stem cell transplant as part of his treatment for acute myeloid leukemia (AML).[14] A second transplant was made a year later after a relapse. The donor was chosen not only for genetic compatibility but also for being homozygous for a CCR5-32 mutation that confers resistance to HIV infection.[15][16] After 20 months without antiretroviral drug treatment, it was reported that HIV levels in Brown's blood, bone marrow, and bowel were below the limit of detection.[16] The virus remained undetectable over three years after the first transplant.[14] Although the researchers and some commentators have characterized this result as a cure, others suggest that the virus may remain hidden in tissues[17] such as the brain (which acts as a viral reservoir).[18] Stem cell treatment remains investigational because of its anecdotal nature, the disease and mortality risk associated with stem cell transplants, and the difficulty of finding suitable donors.[17][19]

Complementing efforts to control viral replication, immunotherapies that may assist in the recovery of the immune system have been explored in past and ongoing trials, including IL-2 and IL-7.[20]

The failure of vaccine candidates to protect against HIV infection and progression to AIDS has led to a renewed focus on the biological mechanisms responsible for HIV latency. A limited period of therapy combining anti-retrovirals with drugs targeting the latent reservoir may one day allow for total eradication of HIV infection.[21] Researchers have discovered an abzyme that can destroy the protein gp120 CD4 binding site. This protein is common to all HIV variants as it is the attachment point for B lymphocytes and subsequent compromising of the immune system.[22]

A turning point for HIV research occurred in 2007, following the bone marrow transplant of HIV sufferer Timothy Ray Brown. Brown underwent the procedure after he developed leukaemia and the donor of the bone marrow possessed a rare genetic mutation that caused Brown's cells to become resistant to HIV. Brown attained the title of the "Berlin Patient" in the HIV research field and is the first man to have been cured of the virus. As of April 2013, two primary approaches are being pursued in the search for a HIV cure: The first is gene therapy that aims to develop a HIV-resistant immune system for patients, and the second is being led by Danish scientists, who are conducting clinical trials to strip the HIV from human DNA and have it destroyed permanently by the immune system.[23]

Two more cases with similarities to the Brown case have occurred since the 2007 discovery; however, they differ because the transplanted marrow has not been confirmed as mutated. The cases were publicized in a July 2013 CNN story that relayed the experience of two patients who had taken antiretroviral therapy for years before they developed lymphoma, a cancer of the lymph nodes. They then underwent lymphoma chemotherapy and bone marrow transplantation, while remaining on an antiretroviral regimen; while they retained traces of HIV four months afterwards, six to nine months after the transplant, the two patients had no detectable trace of HIV in their blood. However, the managing clinician Dr. Timothy Heinrich stated at the Malaysian International AIDS Society Conference where the findings were presented:

It's possible, again, that the virus could return in a week, it could return in a month -- in fact, some mathematical modeling predicts that virus could even return one to two years after we stop antiretroviral therapy, so we really don't know what the long-term or full effects of stem cell transplantation and viral persistence is.[24]

In March 2016, researchers at Temple University, Philadelphia, reported that they have used genome editing to delete HIV from T cells. According to the researchers, this approach could lead to a dramatic reduction of the viral load in patient cells.[25][26]

In April 2016, Innovative Bioresearch, a privately held company owned by research scientist Jonathan Fior, reported the results of a pioneering pilot study that explored the infusion of SupT1 cells as a cell-based therapy for HIV in a humanized mouse model.[27][28] This novel cell-based therapy uses irradiated SupT1 cells as a decoy target for HIV to prevent CD4+ T cell depletion as well as to render the virus less cytopathic. The research showed that in animals treated with SupT1 cell infusion, significantly lower plasma viral load (~10-fold) and potentially preserved CD4+ T cell frequency were observed at Week 1, with one animal showing complete suppression of viral replication and preservation of CD4+ T cell count (no virus detected anymore at Weeks 3 and 4). Interestingly, as also mentioned in a previous paper wrote by the same author, Jonathan Fior, in vitro studies of HIV evolution showed that prolonged virus replication in the SupT1 cell line results in a less cytopathic virus with a reduced capacity for syncytium formation, a higher sensitivity to neutralization, improved replication in SupT1 cells and impaired infection of primary CD4+ T cell.[29] According to the research, this indicates that in vivo virus replication in the infused SupT1 cells should also have a vaccination effect.[28]

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HIV/AIDS research - Wikipedia

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Communities Voices and Insights – Washington Times

Thursday, December 8th, 2016

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Communities Voices and Insights - Washington Times

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Media reports about autologous haematopoietic stem cell …

Friday, November 25th, 2016

There are many stories in the media about autologous haematopoietic stem cell transplant, also known as bone marrow transplant, AHSCT or HSCT, as a treatment for MS.

In particular, we are aware that the 60 Minutes program this weekend will provide a report about a patients AHSCT treatment experience in Russia. MS Research Australia was available to interview for this story, however, 60 Minutes declined our involvement.

Media reports often describe AHSCT as being a miracle cure for MS and include personal stories of how it has given people a new lease of life. While the results of this treatment have been life-changing for some people, it is important to recognise that this is unlikely to be a treatment that is appropriate for everyone.

The media reports rarely discuss the full details of the treatment, which is very intensive and carries significant risks. The reports also do not provide a full picture regarding other people who may have received the treatment but had a less positive response. To understand how this treatment option may sit within the range of other treatments available, it is important to look at the results for a broader group of people who have been followed up for longer periods of time. MS Research Australia understands that people with MS will wish to explore all potential avenues of treatment. Every persons situation and experience of MS is unique. However, we do encourage all decisions about any MS treatments especially anyone considering travelling overseas for any form of treatment, to always consult with their Australian health care providers, including their neurologist. Health care providers take into consideration the potential benefits, risks and side effects for an individuals particular circumstances. If considering treatment overseas they can ensure that the individual is fully informed about the range of treatment options available in Australia, the nature of the treatment overseas and the providers of that treatment, what can and cant be expected from the treatment, what other health conditions they may have that may impact on the treatment and management of their MS, and what medical care they may need prior to or during travel, or on their return. It is also important to note that not all countries share the same regulatory standards that apply within Australia. The National Health and Medical Research Council have also produced a guide on overseas treatment considerations.

AHSCT has been used in the treatment of blood cancers for several decades, but its use for severe autoimmune disorders has developed relatively more recently. As the safety and efficacy has not yet been tested in sufficiently large randomised controlled trials specifically for MS and in comparison to currently available MS therapies. Therefore globally it is considered experimental for the treatment of MS.

AHSCT is primarily an immune-suppressing chemotherapy treatment combined with reinfusion of blood stem cells to help re-build the immune system. It aims to regenerate a new immune system that is less likely to attack the brain and spinal cord. Further details on the steps involved in this treatment can be found here.

Generally, the outcomes have shown that people who are younger and who still have active inflammatory disease (new lesions on MRI scans and/or relapses) may achieve better outcomes for reducing or halting disease activity. Studies also suggest that AHSCT does not halt or reverse more long-standing disability, or progressive forms of the disease, and it is therefore unlikely that AHSCT would be recommended as a treatment for patients with secondary progressive or primary progressive MS.

Currently, this treatment is provided in Australia through two observational clinical trials, at St Vincents Hospital, Sydney and Austin Health, Melbourne and by a small number of other centres on a case by case basis. These centres have strict eligibility requirements that have been set by the hospital ethics committees and may only apply to limited numbers of patients with MS who have failed to respond to other standard MS treatments. It is for this reason patients need to be referred to these centres by a neurologist, who can provide a detailed clinical history and MRI findings.

AHSCT is playing a role in the range of treatments available to treat MS in Australia, however, for this to become a standard therapy in Australian hospitals for people with MS, further rigorous evidence for the effectiveness, safety and most appropriate use of AHSCT is still required. While some clinical trials of AHSCT for MS are ongoing, there is also consensus amongst MS organisations globally, as well as researchers and clinicians who are involved in the use of this treatment for MS, that a large scale, gold-standard clinical trial is required.

MS Research Australia together with MS Australia have been actively advocating, and will continue to advocate, to the federal government for accessibility to all suitable treatment options for people with MS in Australia. We have also been encouraging dialogue between hospitals, state health departments, haematologists and neurologists to ensure that AHSCT treatment can be provided in Australia for those who need it.

As research continues to determine the safety and long-term effectiveness of AHSCT and for whom the treatment is most likely to be appropriate and effective, MS Research Australia will continue to actively review all AHSCT studies as they become available and report on them via the MS Research Australia website and other communication channels. We have provided a full overview of what is involved in the AHSCT treatment, and a review of research to date, on our website.

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RUSSIAN STEM-CELL THERAPY – healingtherapies.info

Thursday, November 24th, 2016

We are a part of a global community in which the devastation of spinal cord injury (SCI) bows to no flag, and solutions will not be any countrys exclusive domain. Integrating the diverse pieces of the puzzle necessary to develop real-world solutions requires that we open-mindedly work in cooperation and not in competition. With such cooperation, restored function after SCI will be a coalescing reality and not just a never-ending, elusive pie-in-the-sky dream.

In this spirit of bridge-building, I recently traveled to Moscow, Russia where I became the first American scientist to check-out an innovative stem-cell program for SCI developed by the NeuroVita Clinic under the direction of Dr. Andrey Bryukhovetskiy. His work is especially important because few scientists have accumulated as much hands-on experience as he has in treating human SCI with stem cells, an approach many experts believe will play a key therapeutic role in the future.

The Scientist

Im always amazed how good often emerges from the tragic. For example, the Paralyzed Veterans of America (PVA), whose programs have benefited so many with SCI over the years, was born out of World War IIs violence. Bryukhovetskiys promising stem-cell therapies also grew out of a desire to help paralyzed veterans, in this case, those who sustained injury in Russias Afghan and Chechnya military conflicts.

He is a veteran, specifically a 45-year-old retired Colonel who once directed the Russian Navys neurology department. Because of his long-standing empathy for paralyzed veterans, Bryukhovetskiy expressed a desire to collaborate with US veteran organizations, such as PVA, to accelerate the development of real-world SCI therapies.

Bryukhovetskiy is a charismatic leader passionately committed to his mission and patients. His work in humans is built upon a strong foundation of research using a variety of SCI animal models. Because much of his research has been published in Russian, it is not well appreciated in the worlds English-emphasizing scientific community. As seems to be the case for so many innovators regardless of country, he has often struggled to carry out his pioneering research because the vision behind it runs counter to more entrenched perceptions of what is possible after SCI.

Reflecting Hippocrates ancient wisdom that natural forces within us are the true healers of disease, Bryukhovetskiy told me that stem cells are the medicine within us.

In 2002, Bryukhovetskiy established NeuroVita, a state-of-the-art, private clinic that treats a variety of neurological disorders. The clinic occupies several floors in a wing of the massive N.N. Blokhin Russian Cancer Research Hospital Complex five miles southeast of downtown Moscow. Staff includes numerous physicians and rehabilitation specialists, and has access to the expertise of nearby hospital scientists. Although to date patients have been treated under an official scientific research protocol, soon after my visit, the Russian Health Ministry authorized the use of Bryukhovetsiys stem-cell technology for general clinical practice.

Travel

My trip to Moscow went through ten time zones, taking several days for my luggage to catch up. Because of jet lag and Moscows white nights near the summer solstice, it was difficult to sleep at night but nodding off in the day was common. During my visit, I stayed in clinic-affiliated lodging. Although few understood English, and the Russian Cyrillic alphabet makes understanding even more challenging, I was able to get around with relative ease, e.g., take the subway to the Kremlin and Red Square, go to the market, etc.

As a reflection of our emerging global community, television showed, for example, American sitcoms and Arnold Schwarzenegger movies dubbed in Russian, as well as rock videos featuring Britney Spears, unfortunately still in English. Although I was unable to talk to waiters, American rap music was often loudly played in the background. Fortunately, Bryukhovetskiys assistant Maria Zhukova, a former English teacher, provided excellent translational assistance.

Transplanted Cell Types

Stem cells are progenitor cells that have the potential to differentiate into a variety of cells that theoretically can treat various neurological disorders. Bryukhovetskiy has used both embryonic/fetal and adult stem cells.

Although embryonic/fetal stem cells have the greatest potential to mature into a variety of cell types, they are controversial, and it is difficult to direct their differentiation pathway.

Adult stem cells are found in many tissues, including bone marrow, which produces, for example, hematopoietic stem cells that give rise to blood cells, and nervous tissue, whose stem cells can evolve into neurons and neuronal support cells (i.e., glia). Although adult stem cells usually differentiate into the specialized cells associated with the originating tissue, when certain micro-environmental cues are provided, they can mature into cells associated with other tissue. For example, under appropriate circumstances, bone-marrow-derived stem cells have the potential to become nerve cells.

Certain drugs stimulate the bone-marrow to produce more stem cells, which then spillover into the blood, where they can be collected.

When the patient is the source of the cells (i.e., autologous), there is no immunological rejection when they are re-introduced. In contrast, embryonic/fetal cells represent different genetic material (i.e., allogeneic) and have rejection potential, although to some degree their undifferentiated nature helps minimize this risk.

Bryukhovetsiy no longer uses embryonic/fetal stem cells due to the ethical controversy surrounding their use, their rejection potential, and, most importantly, his belief that autologous, adult stem cells are more effective.

In some patients, Bryukhovetskiy has transplanted autologous olfactory ensheathing cells (OECs) using procedures developed by Englands Dr. Geoffrey Raisman. Although not technically stem cells, OECs have considerable regeneration potential and have been the focus of much attention in the SCI research community. When OECs are transplanted into the injured spinal cord, scientists theorize that these cells promote axonal regeneration by producing insulating myelin sheaths around both growing and damaged axons, secreting growth factors, and generating structural and matrix macromolecules that lay the tracks for axonal elongation.

Assessment Procedures

Improvement was evaluated using a variety of assessment procedures, including the commonly used ASIA (American Spinal Injury Association) impairment scale in which grade A and E represents the most and least severe injury, respectively. Although this scale is frequently used, experts emphasize it is often insensitive to small but significant functional improvements. Bryukhovetsiy has noted this insensitivity in his research; i.e. some of his patients with very real life-enhancing improvements did not improve their ASIA grade. Other measurements included FIM (Functional Independence Measure), which assesses dysfunction in daily-living activities; various electrophysiological tests designed to assess neuronal conduction; magnetic resonance imaging (MRI); and urodynamic testing for bladder function.

Transplantation Procedures

Embryonic/Fetal Cells: In 1996, the Russian Health Ministry authorized Bryukhovetskiy to carry out limited clinical trials in SCI. In these early trials, stem cells, neurons, and glia obtained from a various tissues, including 12-week-old human fetuses, were transplanted into the spinal cord/fluid of 17 patients with SCI. Their ages ranged from 16-52 (average 30) years, and the time interval between injury and transplantation ranged from 1-20 (average 5) years. Six, ten, and one had cervical, thoracic, and lumbar injuries respectively. In addition to cell transplantation, all had a variety of other procedures performed depending upon their unique injuries.

Before treatment, 14 subjects were ASIA grade A and three were grade B. After transplantation (0.5 - 3-year follow-up period), four were grade A, five grade B, and seven grade C. Fifteen had some sensory improvement, seven had motor improvement, and 12 had improved bladder function.

SpheroGel & Autologous Cells: Bryukhovetskiys team has implanted SpheroGel (a biodegradable polymer matrix) with embedded cells in six patients who required reconstructive surgeries. In three, hematopoietic stem cells were embedded, and, in the three others, olfactory cells. At follow-up (3-8 months), two grade-A patients had improved to grade C, and one had advanced to grade B. In one patient (grade B initially), there was no improvement.

Intrathecal Stem-Cell Transfusion: The intrathecal transfusion of autologous hematopoietic stem cells is the procedure most currently used. In this relatively straight-forward procedure involving no surgery, the patients stem cells are collected without anesthesia and stored with viability until they are transfused back into the patient.

To stimulate hematopoietic stem-cell production and, in turn, cell accumulation in the blood, patients typically received eight subcutaneous injections over four days of granulocytic colony-stimulating factor, a drug also called Neupogen or Filgrastim. On day five, the patient is hooked up to a blood separator. Over 3-4 hours, blood is drawn from a vein; processed by the separator, which isolates the stems cells; and returned through another vein.

The collected stem cells are concentrated by centrifugation and slowly frozen in liquid nitrogen (-170o centigrade) in the presence of dimethyl sulfoxide (DMSO), a cryopreservative that allows cells to be frozen with minimal damage. Care is taken to check for infections so that they will not be later introduced behind the protective blood-brain barrier during transfusion.

At the time of transfusion, the stem-cell suspension is thawed and about 5.3-million cells injected intrathecally into the subarachnoid space (i.e., into the spinal fluid) through a L3-L4 lumbar puncture using a local anesthetic. The procedure, which I observed, is quick and straightforward. The patient can repeat the transfusion in two months. Bryukhovetskiy believes multiple transfusions enhance functional recovery.

In contrast to hematopoietic stem cells, positive results have been limited with the intrathecal transfusion of olfactory cells, previously isolated and cultured from the patients nasal tissue.

Although Bryukhovetskiys team has collected stem cells from about 120 patients, for a variety of reasons, including the presence of latent infections, only about 60 have had cells reintroduced. Of these 60, 18 have had the recommended multiple transfusions. In turn, 61% of the 18 showed some functional recovery, in some cases dramatic.

Because most patients transfusions were relatively recent, it is too early to assess long-term benefit. Early improvements are unlikely caused by comparatively slow neuronal regeneration processes and are probably triggered by altering the injury sites environment through the secretion of growth factors and other molecules.

For more scientifically inclined readers, Bryukhovetskiy hypothesizes that the stem-cells regenerative effects are mediated through an important growth factor called ciliary neurotrophic factor (CNTF) and its interaction with a key transmembrane receptor called gp130. This interaction, in turn, influences cell differentiation.

Physical Rehabilitation

Like others who are developing function-restoring therapies, Bryukhovetskiy strongly believes that improvement after treatment depends upon the patients commitment to aggressive physical rehabilitation designed to maximize restored function. Basically, if muscles have been disconnected from brain control for many years, its going to take some real work to build up nascent connections. As such, his clinic emphasizes diverse rehabilitation modalities, ranging from aggressive exercises to passive massage and acupuncture therapy.

Patients

I had the opportunity to interact with a number of NeuroVita patients. Because their treatments have been relatively recent, accrued improvements have been generally modest.

Vladimir, a 40-year old Russian living in Spain, sustained a thoracic T6 complete injury from a 2001 car accident, and started a series of stem-cell transfusions late last year. He believes that these recent transfusions, combined with extensive physical therapy, has resulted in additional leg movement, including the ability to walk in a swimming pool.

An articulate 19-year-old Russian living in Bulgaria, Dmitri sustained a cervical C5-6 injury in a 2000 skiing accident. He has had three transfusions since the beginning of 2005 and has noted new sensation and sweating. He had some slight headaches soon after the transfusions.

From Dagestan, Baziat, 21, sustained a T9-11 injury when she was 19. After four transfusions, she has regained additional leg and hip function.

Alexey, 32, traveled in from the distant Kamchatka Peninsula on Russias far eastern Pacific side, much closer to Alaska than Moscow. He shared with me the challenges of living with a severe physical disability in a remote, almost frontier-like area of Russia. Sustaining a T-8 gunshot injury 11 years ago, he received his first transfusion last year and was scheduled to receive his third during my visit. He has acquired more bladder and bowel function and has increased leg strength and tension.

Olga, 17, sustained a T8-9 injury seven years ago from an accident. Last year, cell-containing SpheroGel was implanted in the 4-cm gap in her spinal cord. Since then, she also has had six intrathecal transfusions. Olga indicated some increased lower-back strength and improved inner sensation.

A year after injury, another Olga had the 5-cm gap at her T12-injury site filled with SpheroGel embedded with regenerative cells. About a year after surgery, she suddenly started gaining some dramatic improvement, which she demonstrated to me in NeuroVitas rehabilitation facility.

These are just the patients that I met. For those interested in further patient feedback, the clinic has developed a DVD with English subtitles that includes interviews with other NeuroVita patients.

Conclusion

Although by itself probably not an end-all SCI panacea, this Russian stem-cell therapy is an exceedingly important piece of the puzzle that brings us ever closer to our overall goal of restored function after injury. Hopefully, American scientists can open-mindedly establish collaborations with Bryukhovetskiy so that Americans with SCI can more readily benefit.

Although Bryukhovetskiys work is of paramount importance, when discussing hot scientific topics like stem-cell therapy, it is easy to lose track of the fact that it is the patient who ultimately counts, not the science. In sciences cold objective eye, the patient becomes a research subject characterized by an impairment-scale, etc, and whose subjective opinions are often left in the dust of our quest for scientific purity.

I was grateful for the opportunity to interact with NeuroVitas patients, appreciating their willingness to share with me not only their pain and frustration, but their hope, optimism, and belief in the future. As a somewhat jaded disability-research veteran, their spirit fueled mine.

In this clinic and others throughout the world I have visited, the face of SCI seems so similar. Often with the support of devoted parents, youthful patients with great resolve, motivation, and old-soul wisdom that belies their youth pursue their dreams of recovery unencumbered with the limited expectations of the past.

In spite of unique injuries, there seems to be a collective soul of SCI in these patients that transcends culture and country. Although the efforts of innovative scientists, such as Bryukhovetskiy, are invaluable, the patients are the true pioneers. They each send forth a ripple of hope that is converging into a powerful current which will inevitably wash away SCIs imprisoning walls.

Contact Information: NeuroVita Clinic, Kashirskoye Avenue 23A, Moscow, Russia; info@neurovita.ru or http://www.NeuroVita.ru.

Adapted from article appearing in September 2005 Paraplegia News (For subscriptions, call 602-224-0500) or go to http://www.pn-magazine.com).

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Biology Conferences | Integrative Biology Conferences …

Tuesday, November 22nd, 2016

Sessions/Tracks

Conference Series Ltd invites participants from all over the world to 5thInternational Conference onIntegrative Biology(Integrative Biology 2017) is scheduled to be held during July 19-21, 2017in London, UK,which aims to gather the most elegant societies and industries along with the renowned and honorable persons form top universities across the globe.

As name Integrative Biology reflects belief that the study of biological systems is best approached by incorporating many perspectives like Cell Biology,Molecular biology, Tissue Engineering and Regenerative Medicine,Stem Cell Biology, Genetic Engineering and rDNA Technology, Computational Biology & Bioinformatics, Systems Biology, Developmental Biology,Structural biology,Bio-Engineering, Genomics, Cancer Biology, Biophysics. We bring together a diversity of disciplines that complement one another to unravel the complexity of biology. The concept includesanatomy, physiology,cell biology,biochemistryandbiophysics, and covers animals, human and microorganisms. Our broad range of expertise includes: cell biologist, geneticists, physiologists, molecular biologist, computational biologist, systems biologists, structural biologist, bioinformaticians, biophysicists and biotechnologists.

Track 1: Integrative Biology

An Integrative Biology approach addresses the biological question(s) by integrating holistic (genome wide; omics-) approaches with in depth functional analysis and computation biology (modeling), thereby integrating wet and dry lab approaches. Integrative Biology 2017 offers a premier forum to share trans-disciplinary integrative thinking to unravel the underlying principal mechanisms and process in biology and medicine.

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Track-2: Cell Biology

Cell biologyis a branch of biology that studies cells their physiological properties, their structure, the organelles they contain, interactions with their environment, their life cycle, division, death and cell function. This is done both on a microscopic and molecular level. Cell biology research encompasses both the great diversity of single-celled organisms like bacteria andprotozoa, as well as the many specialized cells in multicellular organisms such as humans, plants, and sponges. The advancing live cell imaging encompasses its applications to Biochips for cell biology, Single-cell ros imaging and Experimental models and clinical transplantation in cell biology and indeed many more. Most recent researches are going on for cell biology on these topics: Cell Organelles: Function and Dysfunction, Cell Biology of Host-Pathogen Interactions,Cancer Cell Biology, Cell Biology of Metabolic Diseases,Cell Biology of Ageing, Cell Signaling and Intracellular Trafficking,Cell Death, Autophagy,Cell Stress, Cell Division and Cell Cycle.

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Track-3: Tissue Engineering

Tissueis a cellular organizational level intermediate between cells and a complete organ.Tissue engineeringis the use of a combination of cells for characterization of engineered tissues, engineering and materials methods to study the advanced technologies in tissue assembly for new insights intoregenerative tissue, and suitable biochemical and physicochemical factors to improve or replace biological functions. While it was once categorized as a sub-field ofbiomaterials, having grown in scope and importance it can be considered as a field in its own right.

Major universities as of University of California, University of Pennsylvania and, Leigh University has come up with the research ofTissue Biologyencouraging and attracting students round the globe for the same.

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Track-4: Stem Cell Biology

Stem cellsare cells originate in all multi-cellular organisms. They were isolated in mice in 1981 and in humans in 1998. In humans there are several types of stem cells, each with variable levels of potency. Stem cell treatments are a type ofcell therapythat introduces new cells into adult bodies for possible treatment ofcancer,diabetes, neurological disorders and other medical conditions. Stem cells have been used to repair tissue damaged by disease or age. In a developing embryo, stem cells can differentiate into all the specialized cellsectoderm, endoderm and mesoderm, but also maintain the normal turnover ofregenerative organs, such as blood, skin, or intestinal tissues.

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Track-5: Developmental Biology

Developmental Biology session mainlyfocuses on mechanisms ofdevelopment, differentiation, andgrowthinanimals molecular, cellular, genetic and evolutionary levels. Areas of particular emphasis include transcriptional control mechanisms, embryonic patterning,cell-cell interactions, growth factors and signal transduction, and regulatory hierarchies in developing plants and animals. Research Areas Include:- Molecular geneticsof development, Control ofgene expression, Cell interactions and cell-matrix interactions, Mechanisms of differentiation, Growth factors and oncogenes,Regulation of stem cell populations, Evolution of developmental control, and Gametogenesis and fertilization.

AgainNational Science Foundationhas bought its focus on Developmental Biology Branch too for funding and encouraging research. TheWelcome Trusttoo supports the Four Year PhD Programme with its funding to encourage the growing research interest in the field.

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Track-6: Cancer Biology

Cancer biology encompasses the application of systems biology approaches to cancer research, in order to study the disease as a complex adaptive system with emerging properties at multiple biological scales. More explicitly, because cancer spans multiple biological, spatial and temporal scales, communication and feedback mechanisms across the scales create a highly complex dynamic system.

Cancer biologytherefore adopts a holistic view of cancer aimed at integrating its many biological scales, including genetics, signaling networks,epigenetics, cellular behavior, histology, (pre)clinical manifestations and epidemiology. Basic researchers and clinicians have progressively recognized the complexity of cancer and of its interaction with the micro- and macro-environment, since putting together the components to provide a cohesive view of the disease has been challenging and hampered progress. Most recent research are going onCancer Genetics,Carcinogenesis,DNA damage and repair, Apoptosis,angiogenesis, and metastasis, Tumor microenvironment, Molecular mechanisms of Cancer Pathogenesis ,Cancer stem cells, Discovery of tumor suppressor genes, Aberrant signaling pathways in tumor cells, Roles of ubiquitination pathways in cancer,Molecular cancer epidemiology, Cancer detection and therapy.

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Track-7: Molecular Biology

Molecular biologyconcerns the molecular basis of biological activity between the various systems of a cell, including the interactions between the different types of DNA, RNA and proteins and theirbiosynthesis, and studies how these interactions are regulated. It has many applications like in gene finding, molecular mechanisms of diseases and its therapeutic approaches by cloning, expression and regulation of gene. Research area includes gene expression, epigenetics and chromatin structure and function,RNA processing, functions of non-coding RNAs, transcription. Nowadays, Most advanced researches are going on these topics: Molecular biology, DNA replication, repair and recombination,Transcription, RNA processing, Post-translational modification, proteomics, Mutation, Site-directed mutagenesis,Epigenetics,chromatin structure and function, Molecular mechanisms of diseases.

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Trcak-8: Structural Biology

Structural biologyseeks to provide a complete and coherent picture of biological phenomena at the molecular and atomic level. The goals of structural biology include developing a comprehensive understanding of the molecular shapes and forms embraced by biological macromolecules and extending this knowledge to understand how different molecular architectures are used to perform the chemical reactions that are central to life. Most recent topics related to structural biology are: Structural Biochemistry,Structure and Function Determination, Hybrid Approaches for Structure Prediction,Structural Biology In Cancer Research,Computational Approaches in Structural Biology,Strucutural Biology Databases.

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Track-9: Genetic Engineering and rDNA Technology

Genetic engineeringis a broad term referring to manipulation of an organisms nucleic acid. Organisms whose genes have been artificially altered for a desired affect is often called genetically modified organism (GMO).Recombinant DNA technology(rDNA) is technology that is used to cut a knownDNA sequencefrom one organism and introduce it into another organism thereby altering the genotype (hence the phenotype) of the recipient. The process of introducing the foreign gene into another organism (or vector) is also called cloning. Sometimes these two terms are used synonymously.

Basically, these techniques are used to achieve the following:

Study the arrangement, expression andregulation of genes, Modification of genes to obtain a changed protein product, Modification ofgene expressioneither to enhance or suppress a particular product, Making multiple copies of anucleic acid segmentartificially, Introduction of genes from organism to another, thus creating a transgenic organism, Creation of organism with desirable or altered characteristics.

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Track-10: Genomics

Genomics researchoften requires the development of new techniques utilizing Genomics and bioinformatics tools for target assessment, including both experimental protocols and data analysis algorithms, to enable a deeper understanding of complex biological systems. In this respect, the field is entering a new and exciting era; rapidly improving next-generationDNA sequencingtechnologies, Cloud computing, hadoop in genomics, now allow for the routine sequencing of entire genomes and Transcriptomes, or of virtually any targeted set of DNA or RNA molecules.

Genomic labs have the fastest growing market with nearly 250 universities concentrating on its research majorly to be named Whitetail Genetic Research Institute, Stanford University, National Human Genome Research Institute. Major companies concentrating on the research are Affymetrix, Applied Biosystems, Foster City, Genentech etc.The scope and research areas of genomics includes genomics and bioinformatic tools for target assessment, structural,functional and comparitive genomics,genomics in marine monitoring,applications of genomics and bioinformatics, infectious disease modelling and analysis,oncogenomics,clinical genomics analysis,microbial genomics, plant genomics,medical genomics,epigenomics and DNA and RNA structure/functionstudies but are not limited to this only. The promise of genomics is huge. It could someday help us maximize personal health and discover the best medical care for any condition. It could help in the development of new therapies that alter the human genome and prevent (or even reverse) complications from the diseases we inherit.

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Track-11: Computational Biology & Bioinformatics

Computational Biologyis both an umbrella term for the body of biological studies that use computer programming as part of their methodology, as well as a reference to specific analysis by Bioinformatic tools for protein analysis that are repeatedly used, particularly in the fields of Structural andfunctional genomics,comparative genomicsand bioinformatics insystems biology. Common uses of bioinformatics include the identification of candidategenes and nucleotides(SNPs). Often, such identification is made with the aim of better understanding the Translational bioinformatics forgenomic medicine, Genomics in marine monitoring, andapplications of genomicsand bioinformatics.

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Track-12: Systems Biology

Systems biologyis the study ofTheoretical aspects of systems biologyof biological components, which may be molecules, cells, organisms or entire species. Living systems are dynamic and complex and their behavior may be hard to predict from the properties of individual parts.

It involves the computational (involvingInsilico modeling in systems biology,Biomarker identification in systems biology) and mathematical modeling of complex biological systems. An emerging engineering approach applied to biomedical and biological scientific research, systems biology is a biology-based inter-disciplinary field of study that focuses on complex interactions within biological systems, using a holistic approach (holism instead of the more traditional reductionism) to biological and biomedical research involving the use of In vitro regulatory models in systems biologyusingOMICS tools. Particularly from year 2000 onwards, the concept has been used widely in the biosciences in a variety of contexts.

ManyFunding Opportunitiesin this research has been bought up bySupport ISB,National Science Foundation,NIHand many CollaborativeFunding Opportunities.

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Track-13: Bio-Engineering

Biological engineering (Cellular and Molecular Bio-Engineering) or bioengineering (including biological systems engineering) is the application of concepts and methods of biology (and secondarily of physics, chemistry, mathematics, and computer science (In vitro testing in bioengineering) to solve real-world problems related to the life sciences or the application thereof, using engineering's own analytical and synthetic methodologies (defined asSynthetic bioengineering) and also its traditional sensitivity to the cost and practicality of the solution(s) arrived at. In this context, while traditional engineering applies physical and mathematical sciences to analyze, design and manufacture inanimate tools, structures and processes, biological engineering uses primarily the rapidly developing body of knowledge known as molecular biology to study and advance applications of living organisms and to create biotechnology likeCancer Bioengineeringused forOrgan bioengineering and regeneration.

Bio-engineering study remains the main interest of research with more than 340 schools focusing on it majorly beingJohns Hopkins University in Baltimore,Georgia Institute of Technology,University of California - San Diego,University of Washington,and Stanford University.

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Track-14: Biophysics

Biophysicsis that branch that applies the principles of physics and chemistry and the methods of mathematical analysis and computer modeling to understand how biological systems work. It seeks to explain biological function in terms of the molecular structures and properties of specific molecules. An important area of biophysical study is the detailed analysis of the structure of molecules in living systems. The recent research areas are biophysical approaches tocell biology, cellular movement andcell motility, computational and theoretical biophysics, molecular structure and behavior of lipids, proteins and nucleic acids, molecular structure & behavior ofmembrane proteins, role of biophysical techniques in analysis and prediction, biophysical mechanisms to explain specific biological processes and Nano biophysics. Most recent researchers are going on: Biophysical approaches to cell biology,Cellular Movement and Cell Motility,Computational and theoretical biophysics,Molecular Structure and Behavior of Lipids,Proteins and Nucleic Acids,Molecular Structure & Behavior of Membrane Proteins,Role of Biophysical Techniques in analysis and prediction,Biophysical Mechanisms to explain specific biological processes.

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The UK is one of the best places in the world for life sciences, on a par with premier life science destinations such as Boston, San Francisco, San Diego and Singapore. We have 4 of the top 10 universities in the world, 19 of the top 100 universities, one of the worlds 3 major financial centers, a stable of quality service providers, world class charitable supporters of the industry and a rich heritage of globally recognized medical research. There are nearly 5,633 life sciences companies in the UK employing an estimated 222,000 people and generates a combined estimated turnover of 60.7 billion. The industry sells into a global industry with current total market values of US$956bn for pharmaceutical and biologics, US$349bn for medical technology and US$50bn for the rapidly growing industrial biotechnology market. There are significant levels of health life sciences employment. This breaks down into: 107,000 employed in the biopharmaceutical sector and service and supply chain in 1,948 companies, generating 39.7 billion turnover; 115,000 employed in the medical technology sector and service and supply chain in 3,685 companies, generating 21 billion turnover. Two thirds of employment is outside of London and the South-East with significant concentrations in the East of England (15%, almost 34,000 people) and North-West (12%, almost 26,000 people). It shows that the UK is second only to the US in terms of life science Foreign Direct Investment projects along with the UKs relative strength in the academic base and clinical research landscape. Combined with the strength of the health life sciences supply chain, these factors are driving investment, growth and employment across the country.

Adjusting for these methodology changes overall jobs growth in the sector is estimated to be 2.9% and overall revenue growth is estimated to be 0.8%. The life science industry is global and 42% of employment is at UK owned companies and 49% of employment is at overseas-owned companies and 10% where the ownership location is unknown.

UK life science companies continue to tackle long-term health challenges such as cancer and antimicrobial resistance, and in addition to this many companies are using bioscience to address a range of issues including environmental challenges and chemical production. This predominantly healthcare manifesto also recognizes the growing importance of these new applications.

Why London??

Londons life sciences sector is a shining jewel and a cornerstone of the citys economy. With a rich history of achievements and medical firsts, the sector employs more than 21,000 in private sector industry, hospitals and research facilities including more than 2,000 researchers. The sector impact is in the manner: $720 Million Indirect benefits/ Economic Spinoffs; 780 number of principal researchers and 19 research institutes. The Major Biotech Companies in London are: Albert Browne Ltd, Parexel Informatics, Alcon Laboratories (UK) Ltd, Baxter Healthcare Ltd, Galderma Laboratories, Agilent Technologies, Abbott Laboratories, and Bayer Healthcare.

London's biotech universities and their spin out companies are Gene Expression Technologies, Photobiotic, Biogenic, Spirogen, Genexsyn, Nervation, Inpharmatica, Immune Regulation Ltd, Cerestem, and MedPharm, Immexis, and Antisoma plc.

London is the capital and most populous city of England, United Kingdom and the European Union. With an estimated 2015 population of 8.63 million within a land area of 1,572 km, London is a leading global city, with strengths in the research and development, arts, commerce, education, entertainment, fashion, finance, healthcare, media, professional services, tourism, and transport all contributing to its prominence. It is one of the world's leading financial centers and has the fifth-or sixth-largest metropolitan area GDP in the world depending on measurement.

London is a world cultural capital. It is the world's most-visited city as measured by international arrivals and has the world's largest city airport system measured by passenger traffic. London's 43 universities form the largest concentration of higher education institutes in Europe.

List of major societies in UK:

Royal Society of Biology Royal Society of Chemistry BBSRC (Biotechnology and Biological Sciences Research Council) The Oxford University Society British Society for Cell Biology Royal Society of Edinburgh Royal Society of Medicine Biochemical Society Astrobiology Society of Britain British Medical Association British Society for the History of Medicine Genetics Society The Mammal Society Royal Institute of Public Health Society for Experimental Biology Zoological Society of London

List of universities and institutes in London:

The Francis Crick Institute, London University College London Imperial College London University of East London Kingston University London University of Westminster Birkbeck, University of London Goldsmiths, University of London King's College London Queen Mary University of London St George's, University of London

The major universities and institutes in UK are:

University of Leeds, University of Leicester, Leeds Trinity University, University of Glasgow, University of Exeter, University of Essex, University of Edinburgh, University of Dundee, Durham University, Cardiff University, University of Chester, University of Bristol, University of Birmingham, University of Bath, University of Cambridge, Anglia Ruskin University, Aston University, University of Bradford, University of East Anglia, University of Liverpool, Loughborough University, University of Nottingham, University of Reading, Queen's University Belfast, University of Sheffield, University of Southampton, University of Sussex, University of Warwick and University of York.

The major Biotech Companies in UK are:

GSK (Stevenage), Martindale Pharmaceuticals Ltd (Brentford), Nova Bio-pharma Holdings Limited, Oxoid Ltd, Omega Pharma Ltd, Quintiles Ltd (Guys Research Centre), Sauflon Pharmaceuticals Limited, Immuno Diagnostic Systems Ltd, Merck Serono Ltd, Quest Diagnostics Ltd, and Fujifilm Diosynth Biotech UK Ltd.

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Human Stem Cells Institute – Wikipedia

Friday, November 11th, 2016

Human Stem Cells Institute Public Tradedas MCX:ISKJ Industry Biotech Research and Pharmaceutical Founded 2003(2003) Headquarters Moscow, Russia

Key people

Human Stem Cells Institute OJSC (HSCI) ( or ) is a Russian public biotech company founded in 2003. HSCI engages in R&D as well as commercialization and marketing of innovative proprietary products and services in the areas of cell-based, gene and post-genome technologies. HSCI aims to foster a new culture of medical care developing new health care opportunities in such areas as personalized and preventive medicine.

Today, HSCIs projects encompass the five main focus areas of modern biomedical technologies: regenerative medicine, bio-insurance, medical genetics, gene therapy, biopharmaceuticals (within the international project SynBio).

HSCI owns the largest family cord blood stem cell bank in Russia Gemabank, as well as the reproductive cell and tissue bank Reprobank (personal storage, donation).

The Company launched Neovasculgen, the first-in-class gene-therapy drug for treating Peripheral Arterial Disease, including Critical Limb Ischemia, and also introduced the innovative cell technology SPRS-therapy, which entails the use of autologous dermal fibroblasts to repair skin damage due to aging and other structural changes.

HSCI is implementing a socially significant project to create its own Russia-wide network of Genetico medical genetics centers to provide genetic diagnostics and consulting services for monogenic inherited diseases as well as multifactorial disorders (Ethnogene, PGD and other services).

The Company actively promotes its products on the Russian market and intends to open new markets throughout the world.

HSCI is listed on the Innovation & Investment Market (iIM) of the Moscow Exchange (ticker ISKJ). The Company conducted its IPO in December 2009, becoming the first Russian biotech company to go public.

In 2003, the Human Stem Cells Institute and Gemabank were established.[1] Over the next few years, the Company increased its client base while expanding its technological abilities. In 2008, HSCI gained a blocking stake in the German biotech company, SymbioTec GmbH, which owns international patents for a new generation of drugs to treat cancer and infectious diseases. In 2009, HSCI successfully raised RUB 142.5 million in an IPO on MICEX and became the first publicly traded biotech company in Russia.[2] The Company continued to expand in 2010, when it gained a 50% stake in Hemafund, Ukraines largest family cord blood bank. In 2011, HSCI initiated the SynBio Project, as a long-term partnership with RUSNANO (a state-owned fund for supporting nanotechnologies) and some major R&D companies from Russia and Europe including Pharmsynthez, Xenetic Biosciences and SymbioTec (which was acquired by Xenetic Biosciences pursuant to the SynBio project agreement ).[3] The project is founded on strong principles of international scientific cooperation, as participating research centers are found in England, Germany, and Russia.[4]

HSCI is engaged in scientific studies and research in the main fields of biomedical technology with the aim of creating innovative products (drugs, medical devices, technologies, services, etc.) which are capable of solving urgent and complex challenges faced by clinical medicine today and which could be incorporated into contemporary healthcare practices. Within of each of the main fields of biomedical technology cell (regenerative medicine), gene (genetic medicine) and post-genome (biopharmaceuticals) technologies the Company is currently undertaking several scientific research projects. [5]

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Russia – Wikipedia, the free encyclopedia

Monday, October 17th, 2016

Coordinates: 60N 90E / 60N 90E / 60; 90

Rossijskaja Federacija

26 December 1991

Russia (i; Russian: , tr. Rossija; IPA:[rsij]; from the Greek: Rus'), also officially known as the Russian Federation[12] (Russian: , tr. Rossijskaja Federacija; IPA:[rsijskj fdratsj]), is a transcontinental country in Eurasia.[13] At 17,075,200 square kilometres (6,592,800sqmi),[14] Russia is the largest country in the world, covering more than one eighth of Earth's inhabited land area,[15][16][17] and the ninth most populous, with over 146.6million people at the end of March 2016.[6][7] Extending across the entirety of northern Asia and much of Eastern Europe, Russia spans eleven time zones and incorporates a wide range of environments and landforms. From northwest to southeast, Russia shares land borders with Norway, Finland, Estonia, Latvia, Lithuania and Poland (both with Kaliningrad Oblast), Belarus, Ukraine, Georgia, Azerbaijan, Kazakhstan, China, Mongolia, and North Korea. It shares maritime borders with Japan by the Sea of Okhotsk and the U.S. state of Alaska across the Bering Strait.

The nation's history began with that of the East Slavs, who emerged as a recognizable group in Europe between the 3rd and 8th centuries AD.[18] Founded and ruled by a Varangian warrior elite and their descendants, the medieval state of Rus arose in the 9th century. In 988 it adopted Orthodox Christianity from the Byzantine Empire,[19] beginning the synthesis of Byzantine and Slavic cultures that defined Russian culture for the next millennium.[19] Rus' ultimately disintegrated into a number of smaller states; most of the Rus' lands were overrun by the Mongol invasion and became tributaries of the nomadic Golden Horde in the 13th century.[20] The Grand Duchy of Moscow gradually reunified the surrounding Russian principalities, achieved independence from the Golden Horde, and came to dominate the cultural and political legacy of Kievan Rus'. By the 18th century, the nation had greatly expanded through conquest, annexation, and exploration to become the Russian Empire, which was the third largest empire in history, stretching from Poland on the west to Alaska on the east.[21][22]

Following the Russian Revolution, the Russian Soviet Federative Socialist Republic became the largest and leading constituent of the Union of Soviet Socialist Republics, the world's first constitutionally socialist state.[23] The Soviet Union played a decisive role in the Allied victory in World WarII,[24][25] and emerged as a recognized superpower and rival to the United States during the Cold War. The Soviet era saw some of the most significant technological achievements of the 20th century, including the world's first human-made satellite and the launching of the first humans in space. By the end of 1990, the Soviet Union had the world's second largest economy, largest standing military in the world and the largest stockpile of weapons of mass destruction.[26][27][28] Following the partition of the Soviet Union in 1991, fourteen independent republics emerged from the USSR; as the largest, most populous, and most economically developed republic, the Russian SFSR reconstituted itself as the Russian Federation and is recognized as the continuing legal personality and sole successor state of the Soviet Union.[29] It is governed as a federal semi-presidential republic.

The Russian economy ranks as the twelfth largest by nominal GDP and sixth largest by purchasing power parity in 2015.[30] Russia's extensive mineral and energy resources are the largest such reserves in the world,[31] making it one of the leading producers of oil and natural gas globally.[32][33] The country is one of the five recognized nuclear weapons states and possesses the largest stockpile of weapons of mass destruction.[34] Russia is a great power and a permanent member of the United Nations Security Council, as well as a member of the G20, the Council of Europe, the Asia-Pacific Economic Cooperation (APEC), the Shanghai Cooperation Organisation (SCO), the Organization for Security and Co-operation in Europe (OSCE), and the World Trade Organization (WTO), as well as being the leading member of the Commonwealth of Independent States (CIS), the Collective Security Treaty Organization (CSTO) and one of the five members of the Eurasian Economic Union (EEU), along with Armenia, Belarus, Kazakhstan, and Kyrgyzstan.

The name Russia is derived from Rus, a medieval state populated mostly by the East Slavs. However, this proper name became more prominent in the later history, and the country typically was called by its inhabitants " " (russkaja zemlja), which can be translated as "Russian Land" or "Land of Rus'". In order to distinguish this state from other states derived from it, it is denoted as Kievan Rus' by modern historiography. The name Rus itself comes from Rus people, a group of Varangians (possibly Swedish Vikings)[35][36] who founded the state of Rus ().

An old Latin version of the name Rus' was Ruthenia, mostly applied to the western and southern regions of Rus' that were adjacent to Catholic Europe. The current name of the country, (Rossija), comes from the Byzantine Greek designation of the Kievan Rus', Rossaspelt (Rosa pronounced[rosia]) in Modern Greek.[37]

The standard way to refer to citizens of Russia is "Russians".[38]

Nomadic pastoralism developed in the Pontic-Caspian steppe beginning in the Chalcolithic.[39]

In classical antiquity, the Pontic Steppe was known as Scythia. Beginning in the 8th century BC, Ancient Greek traders brought their civilization to the trade emporiums in Tanais and Phanagoria. The Romans settled on the western part of the Caspian Sea, where their empire stretched towards the east.[dubious discuss][40] In the 3rd to 4th centuries AD a semi-legendary Gothic kingdom of Oium existed in Southern Russia until it was overrun by Huns. Between the 3rd and 6th centuries AD, the Bosporan Kingdom, a Hellenistic polity which succeeded the Greek colonies,[41] was also overwhelmed by nomadic invasions led by warlike tribes, such as the Huns and Eurasian Avars.[42] A Turkic people, the Khazars, ruled the lower Volga basin steppes between the Caspian and Black Seas until the 10th century.[43]

The ancestors of modern Russians are the Slavic tribes, whose original home is thought by some scholars to have been the wooded areas of the Pinsk Marshes.[44] The East Slavs gradually settled Western Russia in two waves: one moving from Kiev toward present-day Suzdal and Murom and another from Polotsk toward Novgorod and Rostov. From the 7th century onwards, the East Slavs constituted the bulk of the population in Western Russia[45] and assimilated the native Finno-Ugric peoples, including the Merya, the Muromians, and the Meshchera.

The establishment of the first East Slavic states in the 9th century coincided with the arrival of Varangians, the traders, warriors and settlers from the Baltic Sea region. Primarily they were Vikings of Scandinavian origin, who ventured along the waterways extending from the eastern Baltic to the Black and Caspian Seas.[46] According to the Primary Chronicle, a Varangian from Rus' people, named Rurik, was elected ruler of Novgorod in 862. In 882 his successor Oleg ventured south and conquered Kiev,[47] which had been previously paying tribute to the Khazars, founding Kievan Rus'. Oleg, Rurik's son Igor and Igor's son Sviatoslav subsequently subdued all local East Slavic tribes to Kievan rule, destroyed the Khazar khaganate and launched several military expeditions to Byzantium and Persia.

In the 10th to 11th centuries Kievan Rus' became one of the largest and most prosperous states in Europe.[48] The reigns of Vladimir the Great (9801015) and his son Yaroslav the Wise (10191054) constitute the Golden Age of Kiev, which saw the acceptance of Orthodox Christianity from Byzantium and the creation of the first East Slavic written legal code, the Russkaya Pravda.

In the 11th and 12th centuries, constant incursions by nomadic Turkic tribes, such as the Kipchaks and the Pechenegs, caused a massive migration of Slavic populations to the safer, heavily forested regions of the north, particularly to the area known as Zalesye.[49]

The age of feudalism and decentralization was marked by constant in-fighting between members of the Rurik Dynasty that ruled Kievan Rus' collectively. Kiev's dominance waned, to the benefit of Vladimir-Suzdal in the north-east, Novgorod Republic in the north-west and Galicia-Volhynia in the south-west.

Ultimately Kievan Rus' disintegrated, with the final blow being the Mongol invasion of 123740[50] that resulted in the destruction of Kiev[51] and the death of about half the population of Rus'.[52] The invading Mongol elite, together with their conquered Turkic subjects (Cumans, Kipchaks, Bulgars), became known as Tatars, forming the state of the Golden Horde, which pillaged the Russian principalities; the Mongols ruled the Cuman-Kipchak confederation and Volga Bulgaria (modern-day southern and central expanses of Russia) for over two centuries.[53]

Galicia-Volhynia was eventually assimilated by the Kingdom of Poland, while the Mongol-dominated Vladimir-Suzdal and Novgorod Republic, two regions on the periphery of Kiev, established the basis for the modern Russian nation.[19] The Novgorod together with Pskov retained some degree of autonomy during the time of the Mongol yoke and were largely spared the atrocities that affected the rest of the country. Led by Prince Alexander Nevsky, Novgorodians repelled the invading Swedes in the Battle of the Neva in 1240, as well as the Germanic crusaders in the Battle of the Ice in 1242, breaking their attempts to colonize the Northern Rus'.

The most powerful state to eventually arise after the destruction of Kievan Rus' was the Grand Duchy of Moscow ("Muscovy" in the Western chronicles), initially a part of Vladimir-Suzdal. While still under the domain of the Mongol-Tatars and with their connivance, Moscow began to assert its influence in the Central Rus' in the early 14th century, gradually becoming the leading force in the process of the Rus' lands' reunification and expansion of Russia.[citation needed] Moscow's last rival, the Novgorod Republic, prospered as the chief fur trade center and the easternmost port of the Hanseatic League.

Times remained difficult, with frequent Mongol-Tatar raids. Agriculture suffered from the beginning of the Little Ice Age. As in the rest of Europe, plague was a frequent occurrence between 1350 and 1490.[54] However, because of the lower population density and better hygienewidespread practicing of banya, a wet steam baththe death rate from plague was not as severe as in Western Europe,[55] and population numbers recovered by 1500.[54]

Led by Prince Dmitry Donskoy of Moscow and helped by the Russian Orthodox Church, the united army of Russian principalities inflicted a milestone defeat on the Mongol-Tatars in the Battle of Kulikovo in 1380. Moscow gradually absorbed the surrounding principalities, including formerly strong rivals such as Tver and Novgorod.

IvanIII ("the Great") finally threw off the control of the Golden Horde and consolidated the whole of Central and Northern Rus' under Moscow's dominion. He was also the first to take the title "Grand Duke of all the Russias".[56] After the fall of Constantinople in 1453, Moscow claimed succession to the legacy of the Eastern Roman Empire. IvanIII married Sophia Palaiologina, the niece of the last Byzantine emperor ConstantineXI, and made the Byzantine double-headed eagle his own, and eventually Russia's, coat-of-arms.

In development of the Third Rome ideas, the Grand Duke IvanIV (the "Terrible")[57] was officially crowned the first Tsar ("Caesar") of Russia in 1547. The Tsar promulgated a new code of laws (Sudebnik of 1550), established the first Russian feudal representative body (Zemsky Sobor) and introduced local self-management into the rural regions.[58][59]

During his long reign, Ivan the Terrible nearly doubled the already large Russian territory by annexing the three Tatar khanates (parts of the disintegrated Golden Horde): Kazan and Astrakhan along the Volga River, and the Siberian Khanate in southwestern Siberia. Thus, by the end of the 16th century Russia was transformed into a multiethnic, multidenominational and transcontinental state.

However, the Tsardom was weakened by the long and unsuccessful Livonian War against the coalition of Poland, Lithuania, and Sweden for access to the Baltic coast and sea trade.[60] At the same time, the Tatars of the Crimean Khanate, the only remaining successor to the Golden Horde, continued to raid Southern Russia.[61] In an effort to restore the Volga khanates, Crimeans and their Ottoman allies invaded central Russia and were even able to burn down parts of Moscow in 1571.[62] But in the next year the large invading army was thoroughly defeated by Russians in the Battle of Molodi, forever eliminating the threat of an OttomanCrimean expansion into Russia. The slave raids of Crimeans, however, did not cease until the late 17th century though the construction of new fortification lines across Southern Russia, such as the Great Abatis Line, constantly narrowed the area accessible to incursions.[63]

The death of Ivan's sons marked the end of the ancient Rurik Dynasty in 1598, and in combination with the famine of 160103[64] led to civil war, the rule of pretenders, and foreign intervention during the Time of Troubles in the early 17th century.[65] The Polish-Lithuanian Commonwealth occupied parts of Russia, including Moscow. In 1612, the Poles were forced to retreat by the Russian volunteer corps, led by two national heroes, merchant Kuzma Minin and Prince Dmitry Pozharsky. The Romanov Dynasty acceded to the throne in 1613 by the decision of Zemsky Sobor, and the country started its gradual recovery from the crisis.

Russia continued its territorial growth through the 17th century, which was the age of Cossacks. Cossacks were warriors organized into military communities, resembling pirates and pioneers of the New World. In 1648, the peasants of Ukraine joined the Zaporozhian Cossacks in rebellion against Poland-Lithuania during the Khmelnytsky Uprising in reaction to the social and religious oppression they had been suffering under Polish rule. In 1654, the Ukrainian leader, Bohdan Khmelnytsky, offered to place Ukraine under the protection of the Russian Tsar, AlekseyI. Aleksey's acceptance of this offer led to another Russo-Polish War. Finally, Ukraine was split along the Dnieper River, leaving the western part, right-bank Ukraine, under Polish rule and the eastern part (Left-bank Ukraine and Kiev) under Russian rule. Later, in 167071, the Don Cossacks led by Stenka Razin initiated a major uprising in the Volga Region, but the Tsar's troops were successful in defeating the rebels.

In the east, the rapid Russian exploration and colonisation of the huge territories of Siberia was led mostly by Cossacks hunting for valuable furs and ivory. Russian explorers pushed eastward primarily along the Siberian River Routes, and by the mid-17th century there were Russian settlements in Eastern Siberia, on the Chukchi Peninsula, along the Amur River, and on the Pacific coast. In 1648, the Bering Strait between Asia and North America was passed for the first time by Fedot Popov and Semyon Dezhnyov.

Under Peter the Great, Russia was proclaimed an Empire in 1721 and became recognized as a world power. Ruling from 1682 to 1725, Peter defeated Sweden in the Great Northern War, forcing it to cede West Karelia and Ingria (two regions lost by Russia in the Time of Troubles),[66] as well as Estland and Livland, securing Russia's access to the sea and sea trade.[67] On the Baltic Sea Peter founded a new capital called Saint Petersburg, later known as Russia's "Window to Europe". Peter the Great's reforms brought considerable Western European cultural influences to Russia.

The reign of PeterI's daughter Elizabeth in 174162 saw Russia's participation in the Seven Years' War (175663). During this conflict Russia annexed East Prussia for a while and even took Berlin. However, upon Elisabeth's death, all these conquests were returned to the Kingdom of Prussia by pro-Prussian PeterIII of Russia.

CatherineII ("the Great"), who ruled in 176296, presided over the Age of Russian Enlightenment. She extended Russian political control over the Polish-Lithuanian Commonwealth and incorporated most of its territories into Russia during the Partitions of Poland, pushing the Russian frontier westward into Central Europe. In the south, after successful Russo-Turkish Wars against Ottoman Turkey, Catherine advanced Russia's boundary to the Black Sea, defeating the Crimean Khanate. As a result of victories over Qajar Iran through the Russo-Persian Wars, by the first half of the 19th century Russia also made significant territorial gains in Transcaucasia and the North Caucasus, forcing the former to irrevocably cede what is nowadays Georgia, Dagestan, Azerbaijan and Armenia to Russia.[68][69] This continued with AlexanderI's (180125) wresting of Finland from the weakened kingdom of Sweden in 1809 and of Bessarabia from the Ottomans in 1812. At the same time, Russians colonized Alaska and even founded settlements in California, such as Fort Ross.

In 18031806, the first Russian circumnavigation was made, later followed by other notable Russian sea exploration voyages. In 1820, a Russian expedition discovered the continent of Antarctica.

In alliances with various European countries, Russia fought against Napoleon's France. The French invasion of Russia at the height of Napoleon's power in 1812 failed miserably as the obstinate resistance in combination with the bitterly cold Russian winter led to a disastrous defeat of invaders, in which more than 95% of the pan-European Grande Arme perished.[70] Led by Mikhail Kutuzov and Barclay de Tolly, the Russian army ousted Napoleon from the country and drove through Europe in the war of the Sixth Coalition, finally entering Paris. AlexanderI headed Russia's delegation at the Congress of Vienna that defined the map of post-Napoleonic Europe.

The officers of the Napoleonic Wars brought ideas of liberalism back to Russia with them and attempted to curtail the tsar's powers during the abortive Decembrist revolt of 1825. At the end of the conservative reign of NicolasI (182555), a zenith period of Russia's power and influence in Europe was disrupted by defeat in the Crimean War. Between 1847 and 1851, about one million people died of Asiatic cholera.[71]

Nicholas's successor AlexanderII (185581) enacted significant changes in the country, including the emancipation reform of 1861. These Great Reforms spurred industrialization and modernized the Russian army, which had successfully liberated Bulgaria from Ottoman rule in the 187778 Russo-Turkish War.

The late 19th century saw the rise of various socialist movements in Russia. AlexanderII was killed in 1881 by revolutionary terrorists, and the reign of his son AlexanderIII (188194) was less liberal but more peaceful. The last Russian Emperor, NicholasII (18941917), was unable to prevent the events of the Russian Revolution of 1905, triggered by the unsuccessful Russo-Japanese War and the demonstration incident known as Bloody Sunday. The uprising was put down, but the government was forced to concede major reforms, including granting the freedoms of speech and assembly, the legalization of political parties, and the creation of an elected legislative body, the State Duma of the Russian Empire. The Stolypin agrarian reform led to a massive peasant migration and settlement into Siberia. More than four million settlers arrived in that region between 1906 and 1914.[72]

In 1914, Russia entered World WarI in response to Austria-Hungary's declaration of war on Russia's ally Serbia, and fought across multiple fronts while isolated from its Triple Entente allies. In 1916, the Brusilov Offensive of the Russian Army almost completely destroyed the military of Austria-Hungary. However, the already-existing public distrust of the regime was deepened by the rising costs of war, high casualties, and rumors of corruption and treason. All this formed the climate for the Russian Revolution of 1917, carried out in two major acts.

The February Revolution forced Nicholas II to abdicate; he and his family were imprisoned and later executed in Yekaterinburg during the Russian Civil War. The monarchy was replaced by a shaky coalition of political parties that declared itself the Provisional Government. An alternative socialist establishment existed alongside, the Petrograd Soviet, wielding power through the democratically elected councils of workers and peasants, called Soviets. The rule of the new authorities only aggravated the crisis in the country, instead of resolving it. Eventually, the October Revolution, led by Bolshevik leader Vladimir Lenin, overthrew the Provisional Government and gave full governing power to the Soviets, leading to the creation of the world's first socialist state.

Following the October Revolution, a civil war broke out between the anti-Communist White movement and the new Soviet regime with its Red Army. Bolshevist Russia lost its Ukrainian, Polish, Baltic, and Finnish territories by signing the Treaty of Brest-Litovsk that concluded hostilities with the Central Powers of World WarI. The Allied powers launched an unsuccessful military intervention in support of anti-Communist forces. In the meantime both the Bolsheviks and White movement carried out campaigns of deportations and executions against each other, known respectively as the Red Terror and White Terror. By the end of the civil war, Russia's economy and infrastructure were heavily damaged. Millions became White migrs,[73] and the Povolzhye famine of 1921 claimed up to 5million victims.[74]

The Russian Soviet Federative Socialist Republic (called Russian Socialist Federative Soviet Republic at the time), together with the Ukrainian, Byelorussian, and Transcaucasian Soviet Socialist Republics, formed the Union of Soviet Socialist Republics (USSR), or Soviet Union, on 30 December 1922. Out of the 15 republics that would make up the USSR, the largest in size and over half of the total USSR population was the Russian SFSR, which came to dominate the union for its entire 69-year history.

Following Lenin's death in 1924, a troika was designated to govern the Soviet Union. However, Joseph Stalin, an elected General Secretary of the Communist Party, managed to suppress all opposition groups within the party and consolidate power in his hands. Leon Trotsky, the main proponent of world revolution, was exiled from the Soviet Union in 1929, and Stalin's idea of Socialism in One Country became the primary line. The continued internal struggle in the Bolshevik party culminated in the Great Purge, a period of mass repressions in 193738, during which hundreds of thousands of people were executed, including original party members and military leaders accused of coup d'tat plots.[75]

Under Stalin's leadership, the government launched a planned economy, industrialisation of the largely rural country, and collectivization of its agriculture. During this period of rapid economic and social change, millions of people were sent to penal labor camps,[76] including many political convicts for their opposition to Stalin's rule; millions were deported and exiled to remote areas of the Soviet Union.[76] The transitional disorganisation of the country's agriculture, combined with the harsh state policies and a drought, led to the Soviet famine of 19321933.[77] The Soviet Union, though with a heavy price, was transformed from a largely agrarian economy to a major industrial powerhouse in a short span of time.

The Appeasement policy of Great Britain and France towards Adolf Hitler's annexation of Austria and Czechoslovakia did not stem an increase in the power of Nazi Germany and initiated a threat of war to the Soviet Union.[citation needed] Around the same time, the Third Reich allied with the Empire of Japan, a rival of the USSR in the Far East and an open enemy of the USSR in the SovietJapanese Border Wars in 193839.

In August 1939, after another failure of attempts to establish an anti-Nazi alliance with Britain and France,[citation needed] the Soviet government decided to improve relations with Germany by concluding the Molotov-Ribbentrop Pact, pledging non-aggression between the two countries and dividing Eastern Europe into their respective spheres of influence. While Hitler conquered Poland and France and other countries acted on a single front at the start of World WarII, the USSR was able to build up its military and claim some of the former territories of the Russian Empire, Western Ukraine, Hertza region and Northern Bukovina as a result of the Soviet invasion of Poland, Winter War, occupation of the Baltic states and Soviet occupation of Bessarabia and Northern Bukovina.

On 22 June 1941, Nazi Germany broke the non-aggression treaty and invaded the Soviet Union with the largest and most powerful invasion force in human history,[78] opening the largest theater of World WarII. Although the German army had considerable early success, their attack was halted in the Battle of Moscow. Subsequently, the Germans were dealt major defeats first at the Battle of Stalingrad in the winter of 194243,[79] and then in the Battle of Kursk in the summer of 1943. Another German failure was the Siege of Leningrad, in which the city was fully blockaded on land between 1941 and 1944 by German and Finnish forces, and suffered starvation and more than a million deaths, but never surrendered.[80] Under Stalin's administration and the leadership of such commanders as Georgy Zhukov and Konstantin Rokossovsky, Soviet forces took Eastern Europe in 194445 and captured Berlin in May 1945. In August 1945 the Soviet Army ousted the Japanese from China's Manchukuo and North Korea, contributing to the allied victory over Japan.

The 194145 period of World WarII is known in Russia as the "Great Patriotic War". The Soviet Union together with the United States, the United Kingdom and China were considered as the Big Four of Allied powers in World War II [81] and later became the Four Policemen which was the foundation of the United Nations Security Council.[82] During this war, which included many of the most lethal battle operations in human history, Soviet military and civilian deaths were 10.6million and 15.9million respectively,[83] accounting for about a third of all World WarII casualties. The full demographic loss to the Soviet peoples was even greater.[84] The Soviet economy and infrastructure suffered massive devastation which caused the Soviet famine of 194647[85] but the Soviet Union emerged as an acknowledged military superpower on the continent.

After the war, Eastern and Central Europe including East Germany and part of Austria was occupied by Red Army according to the Potsdam Conference. Dependent socialist governments were installed in the Eastern Bloc satellite states. Becoming the world's second nuclear weapons power, the USSR established the Warsaw Pact alliance and entered into a struggle for global dominance, known as the Cold War, with the United States and NATO. The Soviet Union supported revolutionary movements across the world, including the newly formed People's Republic of China, the Democratic People's Republic of Korea and, later on, the Republic of Cuba. Significant amounts of Soviet resources were allocated in aid to the other socialist states.[86]

After Stalin's death and a short period of collective rule, the new leader Nikita Khrushchev denounced the cult of personality of Stalin and launched the policy of de-Stalinization. The penal labor system was reformed and many prisoners were released and rehabilitated (many of them posthumously).[87] The general easement of repressive policies became known later as the Khrushchev Thaw. At the same time, tensions with the United States heightened when the two rivals clashed over the deployment of the United States Jupiter missiles in Turkey and Soviet missiles in Cuba.

In 1957, the Soviet Union launched the world's first artificial satellite, Sputnik1, thus starting the Space Age. Russia's cosmonaut Yuri Gagarin became the first human to orbit the Earth, aboard the Vostok1 manned spacecraft on 12 April 1961.

Following the ousting of Khrushchev in 1964, another period of collective rule ensued, until Leonid Brezhnev became the leader. The era of the 1970s and the early 1980s was designated later as the Era of Stagnation, a period when economic growth slowed and social policies became static. The 1965 Kosygin reform aimed for partial decentralization of the Soviet economy and shifted the emphasis from heavy industry and weapons to light industry and consumer goods but was stifled by the conservative Communist leadership.

In 1979, after a Communist-led revolution in Afghanistan, Soviet forces entered that country at the request of the new regime. The occupation drained economic resources and dragged on without achieving meaningful political results. Ultimately, the Soviet Army was withdrawn from Afghanistan in 1989 due to international opposition, persistent anti-Soviet guerilla warfare, and a lack of support by Soviet citizens.

From 1985 onwards, the last Soviet leader Mikhail Gorbachev, who sought to enact liberal reforms in the Soviet system, introduced the policies of glasnost (openness) and perestroika (restructuring) in an attempt to end the period of economic stagnation and to democratise the government. This, however, led to the rise of strong nationalist and separatist movements. Prior to 1991, the Soviet economy was the second largest in the world,[88] but during its last years it was afflicted by shortages of goods in grocery stores, huge budget deficits, and explosive growth in the money supply leading to inflation.[89]

By 1991, economic and political turmoil began to boil over, as the Baltic republics chose to secede from the Soviet Union. On 17 March, a referendum was held, in which the vast majority of participating citizens voted in favour of changing the Soviet Union into a renewed federation. In August 1991, a coup d'tat attempt by members of Gorbachev's government, directed against Gorbachev and aimed at preserving the Soviet Union, instead led to the end of the Communist Party of the Soviet Union. On 25 December 1991, the USSR was dissolved into 15 post-Soviet states.

In June 1991, Boris Yeltsin became the first directly elected President in Russian history when he was elected President of the Russian Soviet Federative Socialist Republic, which became the independent Russian Federation in December of that year. During and after the disintegration of the Soviet Union, wide-ranging reforms including privatization and market and trade liberalization were undertaken,[90] including radical changes along the lines of "shock therapy" as recommended by the United States and the International Monetary Fund.[91] All this resulted in a major economic crisis, characterized by a 50% decline in both GDP and industrial output between 1990 and 1995.[90][92]

The privatization largely shifted control of enterprises from state agencies to individuals with inside connections in the government. Many of the newly rich moved billions in cash and assets outside of the country in an enormous capital flight.[93] The depression of the economy led to the collapse of social services; the birth rate plummeted while the death rate skyrocketed.[94] Millions plunged into poverty, from a level of 1.5% in the late Soviet era to 3949% by mid-1993.[95] The 1990s saw extreme corruption and lawlessness, the rise of criminal gangs and violent crime.[96]

The 1990s were plagued by armed conflicts in the North Caucasus, both local ethnic skirmishes and separatist Islamist insurrections. From the time Chechen separatists declared independence in the early 1990s, an intermittent guerrilla war has been fought between the rebel groups and the Russian military. Terrorist attacks against civilians carried out by separatists, most notably the Moscow theater hostage crisis and Beslan school siege, caused hundreds of deaths and drew worldwide attention.

Russia took up the responsibility for settling the USSR's external debts, even though its population made up just half of the population of the USSR at the time of its dissolution.[97] High budget deficits caused the 1998 Russian financial crisis[98] and resulted in a further GDP decline.[90]

On 31 December 1999, President Yeltsin unexpectedly resigned, handing the post to the recently appointed Prime Minister, Vladimir Putin, who then won the 2000 presidential election. Putin suppressed the Chechen insurgency although sporadic violence still occurs throughout the Northern Caucasus. High oil prices and the initially weak currency followed by increasing domestic demand, consumption, and investments has helped the economy grow for nine straight years, improving the standard of living and increasing Russia's influence on the world stage.[99] However, since the World economic crisis of 2008 and a subsequent drop in oil prices, Russia's economy has stagnated and poverty has again started to rise.[100] While many reforms made during the Putin presidency have been generally criticized by Western nations as undemocratic,[101] Putin's leadership over the return of order, stability, and progress has won him widespread admiration in Russia.[102]

On 2 March 2008, Dmitry Medvedev was elected President of Russia while Putin became Prime Minister. Putin returned to the presidency following the 2012 presidential elections, and Medvedev was appointed Prime Minister.

In 2014, after President Viktor Yanukovych of Ukraine fled as a result of a revolution, Putin requested and received authorization from the Russian Parliament to deploy Russian troops to Ukraine.[103][104][105][106][107] Following a Crimean referendum in which separation was favored by a large majority of voters, but not accepted internationally,[108][109][110][111][112][113] the Russian leadership announced the accession of Crimea into the Russian Federation. On 27 March the United Nations General Assembly voted in favor of a non-binding resolution opposing the Russian annexation of Crimea by a vote of 100 in favour, 11 against and 58 abstentions.[114]

In September 2015, Russia started military intervention in the Syrian Civil War, consisting of air strikes against militant groups of the Islamic State, al-Nusra Front (al-Qaeda in the Levant), and the Army of Conquest.

It could face charges for attacking Syrian City Aleppo. It has also been accused of being behind the Hillary Clinton e-mail hack.

According to the Constitution of Russia, the country is a federation and semi-presidential republic, wherein the President is the head of state[115] and the Prime Minister is the head of government. The Russian Federation is fundamentally structured as a multi-party representative democracy, with the federal government composed of three branches:

The president is elected by popular vote for a six-year term (eligible for a second term, but not for a third consecutive term).[116] Ministries of the government are composed of the Premier and his deputies, ministers, and selected other individuals; all are appointed by the President on the recommendation of the Prime Minister (whereas the appointment of the latter requires the consent of the State Duma). Leading political parties in Russia include United Russia, the Communist Party, the Liberal Democratic Party, and A Just Russia. In 2013, Russia was ranked as 122nd of 167 countries in the Democracy Index, compiled by The Economist Intelligence Unit,[117] while the World Justice Project currently ranks Russia 80th of 99 countries surveyed in terms of rule of law.[118]

The Russian Federation is recognized in international law as a successor state of the former Soviet Union.[29] Russia continues to implement the international commitments of the USSR, and has assumed the USSR's permanent seat in the UN Security Council, membership in other international organisations, the rights and obligations under international treaties, and property and debts. Russia has a multifaceted foreign policy. As of 2009[update], it maintains diplomatic relations with 191 countries and has 144 embassies. The foreign policy is determined by the President and implemented by the Ministry of Foreign Affairs of Russia.[119]

As the successor to a former superpower, Russia's geopolitical status has often been debated, particularly in relation to unipolar and multipolar views on the global political system. While Russia is commonly accepted to be a great power, in recent years it has been characterized by a number of world leaders,[120][121] scholars,[122] commentators and politicians[123] as a currently reinstating or potential superpower.[124][125][126]

As one of five permanent members of the UN Security Council, Russia plays a major role in maintaining international peace and security. The country participates in the Quartet on the Middle East and the Six-party talks with North Korea. Russia is a member of the G8 industrialized nations, the Council of Europe, OSCE, and APEC. Russia usually takes a leading role in regional organisations such as the CIS, EurAsEC, CSTO, and the SCO.[127] Russia became the 39th member state of the Council of Europe in 1996.[128] In 1998, Russia ratified the European Convention on Human Rights. The legal basis for EU relations with Russia is the Partnership and Cooperation Agreement, which came into force in 1997. The Agreement recalls the parties' shared respect for democracy and human rights, political and economic freedom and commitment to international peace and security.[129] In May 2003, the EU and Russia agreed to reinforce their cooperation on the basis of common values and shared interests.[130] Former President Vladimir Putin had advocated a strategic partnership with close integration in various dimensions including establishment of EU-Russia Common Spaces.[131] Since the dissolution of the Soviet Union, Russia has developed a friendlier relationship with the United States and NATO. The NATO-Russia Council was established in 2002 to allow the United States, Russia and the 27 allies in NATO to work together as equal partners to pursue opportunities for joint collaboration.[132]

Russia maintains strong and positive relations with other BRIC countries. India is the largest customer of Russian military equipment and the two countries share extensive defense and strategic relations.[133] In recent years, the country has strengthened bilateral ties especially with the People's Republic of China by signing the Treaty of Friendship as well as building the Trans-Siberian oil pipeline and gas pipeline from Siberia to China.[134][135]

An important aspect of Russia's relations with the West is the criticism of Russia's political system and human rights management (including LGBT rights, media freedom, and reports about killed journalists) by Western governments, the mass media and the leading democracy and human rights watchdogs. In particular, such organisations as the Amnesty International and Human Rights Watch consider Russia to have not enough democratic attributes and to allow few political rights and civil liberties to its citizens.[136][137]Freedom House, an international organisation funded by the United States, ranks Russia as "not free", citing "carefully engineered elections" and "absence" of debate.[138] Russian authorities dismiss these claims and especially criticise Freedom House. The Russian Ministry of Foreign Affairs has called the 2006 Freedom in the World report "prefabricated", stating that the human rights issues have been turned into a political weapon in particular by the United States. The ministry also claims that such organisations as Freedom House and Human Rights Watch use the same scheme of voluntary extrapolation of "isolated facts that of course can be found in any country" into dominant tendencies.[139]

The Russian military is divided into the Ground Forces, Navy, and Air Force. There are also three independent arms of service: Strategic Missile Troops, Aerospace Defence Forces, and the Airborne Troops. In 2006, the military had 1.037million personnel on active duty.[140] It is mandatory for all male citizens aged 1827 to be drafted for a year of service in Armed Forces.[99]

Russia has the largest stockpile of nuclear weapons in the world. It has the second largest fleet of ballistic missile submarines and is the only country apart from the United States with a modern strategic bomber force.[34][141] Russia's tank force is the largest in the world, its surface navy and air force are among the largest ones.

The country has a large and fully indigenous arms industry, producing most of its own military equipment with only few types of weapons imported. Russia is one of the world's top supplier of arms, a spot it has held since 2001, accounting for around 30% of worldwide weapons sales[142] and exporting weapons to about 80 countries.[143] The Stockholm International Peace Research Institute, SIPRI, found that Russia was the second biggest exporter of arms in 2010-14, increasing their exports by 37 per cent from the period 2005-2009. In 2010-14, Russia delivered weapons to 56 states and to rebel forces in eastern Ukraine.[144]

The Russian government's published 2014 military budget is about 2.49 trillion rubles (approximately US$69.3 billion), the third largest in the world behind the US and China. The official budget is set to rise to 3.03 trillion rubles (approximately US$83.7 billion) in 2015, and 3.36 trillion rubles (approximately US$93.9 billion) in 2016.[145] However, unofficial estimates put the budget significantly higher, for example the Stockholm International Peace Research Institute (SIPRI) 2013 Military Expenditure Database estimated Russia's military expenditure in 2012 at US$90.749 billion.[146] This estimate is an increase of more than US$18 billion on SIPRI's estimate of the Russian military budget for 2011 (US$71.9 billion).[147] As of 2014[update], Russia's military budget is higher than any other European nation.

According to 2012 Global Peace Index, Russia is the sixth least peaceful out of 162 countries in the world, principally because of its defense industry. Russia has historically ranked low on the index since its inception in 2007.[148]

According to the Constitution, the country comprises eighty-five federal subjects,[149] including the Republic of Crimea and the federal city of Sevastopol, whose recent establishment is internationally disputed and criticized as illegal annexation.[150] In 1993, when the Constitution was adopted, there were eighty-nine federal subjects listed, but later some of them were merged. These subjects have equal representationtwo delegates eachin the Federation Council.[151] However, they differ in the degree of autonomy they enjoy.

Federal subjects are grouped into eight federal districts, each administered by an envoy appointed by the President of Russia.[154] Unlike the federal subjects, the federal districts are not a subnational level of government, but are a level of administration of the federal government. Federal districts' envoys serve as liaisons between the federal subjects and the federal government and are primarily responsible for overseeing the compliance of the federal subjects with the federal laws.

Russia is the largest country in the world; its total area is 17,125,200 square kilometres (6,612,100sqmi).[155][156] There are 23 UNESCO World Heritage Sites in Russia, 40 UNESCO biosphere reserves,[157] 41 national parks and 101 nature reserves. It lies between latitudes 41 and 82 N, and longitudes 19 E and 169 W.

Russia's territorial expansion was achieved largely in the late 16th century under the Cossack Yermak Timofeyevich during the reign of Ivan the Terrible, at a time when competing city-states in the western regions of Russia had banded together to form one country. Yermak mustered an army and pushed eastward where he conquered nearly all the lands once belonging to the Mongols, defeating their ruler, Khan Kuchum.[158]

Russia has a wide natural resource base, including major deposits of timber, petroleum, natural gas, coal, ores and other mineral resources.

The two most widely separated points in Russia are about 8,000km (4,971mi) apart along a geodesic line. These points are: a 60km (37mi) long Vistula Spit the boundary with Poland separating the Gdask Bay from the Vistula Lagoon and the most southeastern point of the Kuril Islands. The points which are farthest separated in longitude are 6,600km (4,101mi) apart along a geodesic line. These points are: in the west, the same spit on the boundary with Poland, and in the east, the Big Diomede Island. The Russian Federation spans nine time zones.

Most of Russia consists of vast stretches of plains that are predominantly steppe to the south and heavily forested to the north, with tundra along the northern coast. Russia possesses 10% of the world's arable land.[159] Mountain ranges are found along the southern borders, such as the Caucasus (containing Mount Elbrus, which at 5,642m (18,510ft) is the highest point in both Russia and Europe) and the Altai (containing Mount Belukha, which at the 4,506m (14,783ft) is the highest point of Siberia outside of the Russian Far East); and in the eastern parts, such as the Verkhoyansk Range or the volcanoes of Kamchatka Peninsula (containing Klyuchevskaya Sopka, which at the 4,750m (15,584ft) is the highest active volcano in Eurasia as well as the highest point of Asian Russia). The Ural Mountains, rich in mineral resources, form a north-south range that divides Europe and Asia.

Russia has an extensive coastline of over 37,000km (22,991mi) along the Arctic and Pacific Oceans, as well as along the Baltic Sea, Sea of Azov, Black Sea and Caspian Sea.[99] The Barents Sea, White Sea, Kara Sea, Laptev Sea, East Siberian Sea, Chukchi Sea, Bering Sea, Sea of Okhotsk, and the Sea of Japan are linked to Russia via the Arctic and Pacific. Russia's major islands and archipelagos include Novaya Zemlya, the Franz Josef Land, the Severnaya Zemlya, the New Siberian Islands, Wrangel Island, the Kuril Islands, and Sakhalin. The Diomede Islands (one controlled by Russia, the other by the United States) are just 3km (1.9mi) apart, and Kunashir Island is about 20km (12.4mi) from Hokkaido, Japan.

Russia has thousands of rivers and inland bodies of water, providing it with one of the world's largest surface water resources. Its lakes contain approximately one-quarter of the world's liquid fresh water.[160] The largest and most prominent of Russia's bodies of fresh water is Lake Baikal, the world's deepest, purest, oldest and most capacious fresh water lake.[161] Baikal alone contains over one-fifth of the world's fresh surface water.[160] Other major lakes include Ladoga and Onega, two of the largest lakes in Europe. Russia is second only to Brazil in volume of the total renewable water resources. Of the country's 100,000 rivers,[162] the Volga is the most famous, not only because it is the longest river in Europe, but also because of its major role in Russian history.[99] The Siberian rivers Ob, Yenisey, Lena and Amur are among the longest rivers in the world.

The enormous size of Russia and the remoteness of many areas from the sea result in the dominance of the humid continental climate, which is prevalent in all parts of the country except for the tundra and the extreme southeast. Mountains in the south obstruct the flow of warm air masses from the Indian Ocean, while the plain of the west and north makes the country open to Arctic and Atlantic influences.[163]

Most of Northern European Russia and Siberia has a subarctic climate, with extremely severe winters in the inner regions of Northeast Siberia (mostly the Sakha Republic, where the Northern Pole of Cold is located with the record low temperature of 71.2C or 96.2F), and more moderate winters elsewhere. Both the strip of land along the shore of the Arctic Ocean and the Russian Arctic islands have a polar climate.

The coastal part of Krasnodar Krai on the Black Sea, most notably in Sochi, possesses a humid subtropical climate with mild and wet winters. In many regions of East Siberia and the Far East, winter is dry compared to summer; other parts of the country experience more even precipitation across seasons. Winter precipitation in most parts of the country usually falls as snow. The region along the Lower Volga and Caspian Sea coast, as well as some areas of southernmost Siberia, possesses a semi-arid climate.

Throughout much of the territory there are only two distinct seasonswinter and summeras spring and autumn are usually brief periods of change between extremely low and extremely high temperatures.[163] The coldest month is January (February on the coastline); the warmest is usually July. Great ranges of temperature are typical. In winter, temperatures get colder both from south to north and from west to east. Summers can be quite hot, even in Siberia.[165] The continental interiors are the driest areas.

From north to south the East European Plain, also known as Russian Plain, is clad sequentially in Arctic tundra, coniferous forest (taiga), mixed and broad-leaf forests, grassland (steppe), and semi-desert (fringing the Caspian Sea), as the changes in vegetation reflect the changes in climate. Siberia supports a similar sequence but is largely taiga. Russia has the world's largest forest reserves,[166] known as "the lungs of Europe",[167] second only to the Amazon Rainforest in the amount of carbon dioxide it absorbs.

There are 266 mammal species and 780 bird species in Russia. A total of 415 animal species have been included in the Red Data Book of the Russian Federation as of 1997 and are now protected.[168]

Russia has a developed, high-income market economy with enormous natural resources, particularly oil and natural gas. It has the 15th largest economy in the world by nominal GDP and the 6th largest by purchasing power parity (PPP). Since the turn of the 21st century, higher domestic consumption and greater political stability have bolstered economic growth in Russia. The country ended 2008 with its ninth straight year of growth, but growth has slowed with the decline in the price of oil and gas. Real GDP per capita, PPP (current international) was 19,840 in 2010.[169] Growth was primarily driven by non-traded services and goods for the domestic market, as opposed to oil or mineral extraction and exports.[99] The average nominal salary in Russia was $967 per month in early 2013, up from $80 in 2000.[170][171] In March 2014 the average nominal monthly wages reached 30,000 RUR (or US$980),[172][173] while tax on the income of individuals is payable at the rate of 13% on most incomes.[174] Approximately 12.8% of Russians lived below the national poverty line in 2011,[175] significantly down from 40% in 1998 at the worst point of the post-Soviet collapse.[95] Unemployment in Russia was 5.4% in 2014, down from about 12.4% in 1999.[176] The middle class has grown from just 8million persons in 2000 to 104million persons in 2013.[177][178] However, after United States-led sanctions since 2014 and a collapse in oil prices, the proportion of middle-class could halve to 20%.[179] Sugar imports reportedly dropped 82% between 2012 and 2013 as a result of the increase in domestic output.[180]

Oil, natural gas, metals, and timber account for more than 80% of Russian exports abroad.[99] Since 2003, the exports of natural resources started decreasing in economic importance as the internal market strengthened considerably. Despite higher energy prices, oil and gas only contribute to 5.7% of Russia's GDP and the government predicts this will be 3.7% by 2011.[181] Oil export earnings allowed Russia to increase its foreign reserves from $12billion in 1999 to $597.3billion on 1 August 2008, the third largest foreign exchange reserves in the world.[182] The macroeconomic policy under Finance Minister Alexei Kudrin was prudent and sound, with excess income being stored in the Stabilization Fund of Russia.[183] In 2006, Russia repaid most of its formerly massive debts,[184] leaving it with one of the lowest foreign debts among major economies.[185] The Stabilization Fund helped Russia to come out of the global financial crisis in a much better state than many experts had expected.[183]

A simpler, more streamlined tax code adopted in 2001 reduced the tax burden on people and dramatically increased state revenue.[186] Russia has a flat tax rate of 13%. This ranks it as the country with the second most attractive personal tax system for single managers in the world after the United Arab Emirates.[187] According to Bloomberg, Russia is considered well ahead of most other resource-rich countries in its economic development, with a long tradition of education, science, and industry.[188] The country has a higher proportion of higher education graduates than any other country in Eurasia.[189]

The economic development of the country has been uneven geographically with the Moscow region contributing a very large share of the country's GDP.[190] Inequality of household income and wealth has also been noted, with Credit Suisse finding Russian wealth distribution so much more extreme than other countries studied it "deserves to be placed in a separate category."[191][192] Another problem is modernisation of infrastructure, ageing and inadequate after years of being neglected in the 1990s; the government has said $1trillion will be invested in development of infrastructure by 2020.[193] In December 2011, Russia finally[clarification needed] joined the World Trade Organisation, allowing it a greater access to overseas markets. Some analysts estimate that WTO membership could bring the Russian economy a bounce of up to 3% annually.[194] Russia ranks as the second-most corrupt country in Europe (after Ukraine), according to the Corruption Perceptions Index. The Norwegian-Russian Chamber of Commerce also states that "[c]orruption is one of the biggest problems both Russian and international companies have to deal with".[195] The high rate of corruption acts as a hidden tax as businesses and individuals often have to pay money that is not part of the official tax rate. It is estimated that corruption is costing the Russian economy an estimated $2 billion (80 billion rubles) per year.[196] In 2014, a book-length study by Professor Karen Dawisha was published concerning corruption in Russian under Putin's government.[197]

The Russian central bank announced plans in 2013 to free float the Russian ruble in 2015. According to a stress test conducted by the central bank Russian financial system would be able to handle a currency decline of 25%30% without major central bank interference. However, Russian economy began stagnating in late 2013 and in combination with the War in Donbass is in danger of entering stagflation, slow growth and high inflation. The Russian ruble collapsed by 24% from October 2013 to October 2014 entering the level where the central bank may need to intervene to strengthen the currency. Moreover, after bringing inflation down to 3.6% in 2012, the lowest rate since gaining independence from the Soviet Union, inflation in Russia jumped to nearly 7.5% in 2014, causing the central bank to increase its lending rate to 8% from 5.5% in 2013.[198][199][200] In an October 2014 article in Bloomberg Business Week, it was reported that Russia had significantly started shifting its economy towards China in response to increasing financial tensions following its annexation of Crimea and subsequent Western economic sanctions.[201]

Russia's total area of cultivated land is estimated at 1,237,294 square kilometres (477,722sqmi), the fourth largest in the world.[202] From 1999 to 2009, Russia's agriculture grew steadily,[203] and the country turned from a grain importer to the third largest grain exporter after the EU and the United States.[204] The production of meat has grown from 6,813,000 tonnes in 1999 to 9,331,000 tonnes in 2008, and continues to grow.[205]

This restoration of agriculture was supported by a credit policy of the government, helping both individual farmers and large privatized corporate farms that once were Soviet kolkhozes and which still own the significant share of agricultural land.[206] While large farms concentrate mainly on grain production and husbandry products, small private household plots produce most of the country's potatoes, vegetables and fruits.[207]

Since Russia borders three oceans (the Atlantic, Arctic, and Pacific), Russian fishing fleets are a major world fish supplier. Russia captured 3,191,068 tons of fish in 2005.[208] Both exports and imports of fish and sea products grew significantly in recent years, reaching $2,415 and $2,036 million, respectively, in 2008.[209]

Sprawling from the Baltic Sea to the Pacific Ocean, Russia has more than a fifth of the world's forests, which makes it the largest forest country in the world.[166][210] However, according to a 2012 study by the Food and Agriculture Organization of the United Nations and the Government of the Russian Federation,[211] the considerable potential of Russian forests is underutilized and Russia's share of the global trade in forest products is less than four percent.[212]

In recent years, Russia has frequently been described in the media as an energy superpower.[213][214] The country has the world's largest natural gas reserves,[215] the 8th largest oil reserves,[216] and the second largest coal reserves.[217] Russia is the world's leading natural gas exporter[218] and second largest natural gas producer,[33] while also the largest oil exporter and the largest oil producer.[32]

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Why Russia? | From Russia with Lisa…

Sunday, October 2nd, 2016

Are you cringing? Russia for medical treatment, and such a devastating procedure? YES! Why?

Many reasons, first and foremost is that I have utter faith, confidence and assurance in Dr. Denis Fedorenko and his skills to perform a stem cell transplant. Secondly is the cost, approximately $40,000-50,000 depending on hospitalization and need for transfusions or plasma. Third, Dr. Fedorenko will treat patients with my type of MS at my age, something very few, if any, will do in the U.S. I have been communicating with Amy Peterson of Round Rock, Texas. She was the first person in the U.S. to travel to Moscow for HSCT, and has done beautifully! Read about her story athttp://amygoesninja.wordpress.com. She is an inspiration!

The following is information provided by George Goss, the guru of HSCT here in the United States. He is the go to man for questions, help, support and inspiration. He too went overseas for HSCT to Germany which is considered the best of the best. Unfortunately, Germany will not treat my type of MS.

Thank you George

This is anon-myeloablativeHSCT treatment protocol utilizing Cyclophosphamide + Rituxamab or alternatively Cyclophosphamide + Carmustine

Approximate cost USD $40,000+I have spoken with Dr. Fedorenko at Maximov in Moscow on the phone to discuss his HSCT-for-MS treatment. He is a very nice and pleasant personthat clearly is a very knowledgeable medical scientist and clinician and I found him to be open & helpful with my questions.Maximov/Perigovis a well-respected hospital facility. And the best news is that Dr. Fedorenko is definitely extremely knowledgeable and he clearly understands well all the fundamental medical science behind HSCT for treatment and cure of a wide range of hematologically-rooted autoimmune disorders. (Perhaps he can be thought of as providing a similar treatment service in Russia as Dr. Burt does in the USA.) Dr. Fedorenko is also well-published on the subject of HSCT treatment of autoimmune disorders, being involved with numerous and ongoing scientific and medical international symposiums and publications, a few such as listed here (there are many more than just these):

Based upon his publications and experience, Dr. Fedorenko has the credentials establishing him as an expert in the field of HSCT treatment for autoimmune disorders.

Here is the Maximov website: http://www.gemclinic.ru/english.php

Here is relevant info I have learned about Maximovs HSCT treatment for MS:

Maximov performs HSCT for both bone marrow malignancies (such as leukemia) and also several types of autoimmune diseases.

For autoimmune disorders they perform a non-myeloablative HSCT protocol utilizing primarily a combination of carmustine + cyclophosphamide. I never previously heard of this specific chemical combination being used, but it makes sense to me and seems like a reasonable treatment application. I dont see any red flags.

Maximov has ten treatment beds for treating a maximum of ten patients at one time. Five beds reserved for cancer patients, and five beds for patients with autoimmune disorders.

HSCT treatment criteria for autoimmune (MS) conditions:

Exclude patients greater than 50 years of age although he has agreed to accept me pending MRI review

Must be in sufficiently good health to tolerate HSCT procedure) includes good heart and renal function and generally be in good overall health),

And specifically for Multiple Sclerosis patients:

Must not be severely disabled (patient must be ambulatory with an EDSS of less than approximately 6.0) I am on the border here, so I need to get there ASAP!

Will treat any evolutionary form of MS (RRMS, SPMS and PPMS); all allowed but must demonstrate active MRI lesion activity or alternatively if without active lesions must have experienced greater than a 1.0 worsening of EDSS over a period of one year.

Maximov previously treated more than approximately 200 patients (mostly Russians) with autoimmune disorders in which a very small number (3-5) developed serious treatment complications (such as sepsis), of which everyone recovered. There have been no deaths or Treatment Related Mortality (0% TRM).

Treatment Schedule:

Maximum pre-treatment exam duration = 1 week.

Hematopoietic stem cell PBSC mobilization (with G-CSF) = 4-5 days (2-4M HSCs / kg body weight collected).

Peripheral blood stem cell collection / apheresis = 1-2 days.

Usual total in-patient hospital stay (inclusive of all procedures) = 30-45 days. An additional week is required at a nearby hotel to ensure patient health and good blood counts before traveling back to Oklahoma

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why is age so an important part of the requirement, Like I am fit the only problem I have is balance. I am 58 yrs old are we then just left to suffer this disease? I have had it now for 24 years

Dr. Fedorekno has now removed the age limit for MS. I was the oldest to receive the stem call transplant last summer and did very well! He has lifted it due to my success, and a woman age 64 is leaving next week for Moscow and treatment by Dr. Fedorekno. If you are interested, there is a Facebook page you can ask to subscribe to which has great information on HSCT. That is where I became educated. Search for Hematopioetic Stem Cell Transplant MS & Autoimmune Diseases on Facebook. Lisa

I lied, I am 59 today,but it is good to know that he has lifted the age gap, I will have to inform the rest of the group who, go for physio every week and we are in our 50s , the only thing is the price tag for the treatment is not clear, the other question is Russia the only country that is doing this treatment?

The procedure is done in the US in phase III clinical trials, but they will only accept under age 50 with mild cases of RRMS. Germany and India do myeloablative HSCT for $98,000, which is a harsher form of HSCT and takes a full year to recover physically. Non myeolablative (which I had) has been proven just as effective, with a faster recovery period of 3 months on average, 6 months at the very most. Russia costs $40,000; Italy also has just begun to accept MS patients but I do not know their fee. Dr. Fedorenko in Moscow was fabulous, and I put their standards up against any of the finest hospital in the US.

Thank you very much for that, I am off to see the specialist next month and will see what she has to say with Prof Pender, but it looks hopeful.

Neurologists are not fans of HSCT, they are not educated as to the process and the benefits. Hematologists have been doing the procedure for over 20 years for cancer, and 10 years in European countries for MS. As time and news of the success spreads, neurologist will come on board. It will take a few years, however. Do not give up! It has been a life changer and saver for me!

Hello Lisa, My name is Kim I am 55 and have had RRMS for 5 years now I am been on Copaxone for nearly a year and follow a very strict lifestyle of very low saturated fat, meditation,vitamin D,Fish oil no Dairy no meat or chicken just plant base seafood diet which was developed by Proffessor George Jelenek who has MS himself and runs retreats to teach you about this lifesyle ,It has made a huge difference to me in two years I also have acupuncture once a week as well. I had a right hip replacment almost at the same time as my diagnosis and the MS and surgery didnt like eachother so my right leg got worse after surgery. I walk with a cane when Im out but not a home , Im very interested if I would be a candidate for the Stem Cell transplant with Dr Federenko, how could I find out , thankyou Lisa , kind regards , Kim

I feel you would be an excellent candidate. I went from a cane to a walker when out very quickly. Dr. Fedorekno, or any hematologist, would require you be off Copaxone for 3 months before treatment begins. Due to lesions on the spine and brain stem, I would be wheelchair bound right now this very day. HSCT did save me, and has restored many functions, not all of course, but so many! It costs $40,000 US dollars, but my Copaxone cost more than that. Ak me any questions, I will help in any way! Contact Dr. Fedorenko at: info@gemclinic.ru Also find the Facebook page: Russia HSCT for MS & Autoimmune Diseases for more help and information. It is a wonderful group who have been, or are headed to Moscow. Lisa

Hi Lisa I am currently on Techfidera. Would I have to stop that for a certain time before going? Also, do i need a referral and records from my neurologist? Thank you Kind Regards Diana

You would need to stop all treatment, except for medications for symptoms such as Baclofen, etc, before beginning treatment. Dr. Fedorenko usually requires a 3 month cleanse of any disease modifying medications. When I first contacted him by email, I sent a brief description of my disease date and age at onset, date of diagnosis, a full list of symptoms dated from onset to the month I applied, and list of disease modifying meds and how long I had been on each. After he answered, I sent him a CD of my most recent MRI, and a print out of the above mentioned symptoms, onset and meds. Full medical records are usually too much for him to cover, so he has, in the past, gone on the patients notes on their MS. He makes a decision based on what you have told him, and the MRI. He is an amazing physician, never will you find a anyone who cares more about helping people from divesting diseases. Lisa

Hi Lisa

Thank you for your blog. I was diagnosed 1 year ago. I have 2 young children. I have pins and needles and altered sensations on my left leg and both feet. I dont currently require aids to walk. I am overweight. Does this program insist on weight loss? I am Australian and I am on Tysabri. Would I have to come off that first?

To my knowledge, Dr. Fedorenko does not require weight loss. I have had quite a few women whom I now call my best friends who were overweight and had beautifully successful stem cell transplants. I encourage you to proceed with an email to Dr. F. It is your best chance at recovery, and stopping progression, as well as regaining abilities permanently. You wold have to come off Tysabri for 3 months to wash it out of your system before beginning treatment. lisa

Hi Lisa , can I ask you how long has it been since the end of your treatment, and symptoms how are they now ,how long were you sick for during the treatment? my main fear is infection over the isolation period of the transplant and how sterile everything is in the hospital Im very interested in doing this next year ,is there a long waiting list ? Thank you very much Lisa I really appreciate all your advice , kind regards ,Kim xx

I returned home August 12th last year. My symptoms now are so much better, some I have not experienced at all! I am 85% better! Only very few signs of MS remain. I still have at stutter at times, balance issues sometimes, but that is about it! ALL other symptoms are gone no foot pain and burning, no tremors, no paralysis all gone. I suggest you go ahead and apply with Dr. Fedorenko now, as he is booking into early October right now. That will give you time to pursue more research and questions, and will give you time to change your mind should you decide to do so but I think you will not. It is a life saving/changing treatment.

I experienced NO illness during treatment, only sever fatigue. Only slight nausea for a few days, and the rest of the time I was just tired. A sleep 20 hours a day kind of tired. Your body needs the rest so it is beneficial to sleep. The hospital is amazingly, over the top sterile. While in isolation ( go back and see my pics) no one comes in without owning up. Food is twice cooked to ensure all bacteria is removed, and the room cleaned daily with anti bacterial. There is not a more infection free space on this earth. The equipment used during transplant are the newest available, made in Boston, and run on Apple computers designed for this stem cell machine. I was so fearful of going to Russia in the beginning, and all hesitation was wiped away upon meeting Dr. F. He is an angel and all he cares about is helping his patients have a good quality of life, as free of MS as they can be. He did it for me! Lisa

Hi Lisa Just to let you know after your replies from my questions< I contacted my MS clinic and spoke to my consultant and she no way should I consider having this done as they do not tell you about the procedures that went wrong, so I kave made up my mind to wait a bit longer. I am pleased that it worked out for you and it did not go wrong.

Steve

I was diagnosed just Feb of this year. I am in the process of changing Drs at the moment. My Dr did not want to speak about this procedure and literally walked out of the room while I was talking to him. The US doesnt want a cure for this. Drug companies float more $ to Drs for pushing their overpriced immune suppressant drugs than Drs salary most times. Im looking further into this option. I had to find and research it on my own.. still doing a bunch of research. It sounds a million times better than being stuck on Tysabri which will likely cause many other health issues and isnt making me any better. I would love to speak with Lisa! Im mailing my records and MRI to Germany next week.

One of my doctors received $295,500 from pharmaceuticals last year! They DO NOT want a cure. This is an incredible treatment, and gave me so much more than any drug I had been on. It is amazing and has halted the disease! I suggest you try Germany, Moscow now has a long wait list. Singapore does HSCT, as does Florence, Italy a great choice.

Thank you so much Lisa youre a wealth of information and to me this treatment seems so much more beneficial and less dangerous than the horrible MS drugs that the neurologists are prescribing . Five years ago I was an active power walker / gym junkie and now my walking is affected in my right leg I would do anything to walk normally again without a stick . My eldest son is getting married this sept and I want to be an active grandmother one day in the near future and am willing to risk anything for that, Although you have certainly eleviated a lot of my concerns ,I just hope it will help my walking and tingly fingers , thanks again Lisa ,love Kim

Hi lisa as I am one of Jehovahs Witness and dont accept Blood transfusions is it still possible to have this treatment without it? Would they give me something else if my blood count dropped very low? In Australia they give us Erythropoietin, also known as erythropoetin or erthropoyetin or EPO, is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. It is a cytokine for erythrocyte precursors in the bone marrow. I would really appreciate your answer.

In Dr. Fedorenkos 280+ HSCTs, no one has ever had a blood transfusion. I am friends with 15 of the first from the U.S. to go over, and only two of us had to receive platelets. And it was not even medically necessary, but I opted to have them due to fatigue. Hope this helps! Lisa

I am just considering my options and whether or not Russia would be feasible.

I now have two good reports on Russia but more bridges have to be crossed but I have been told that I could be fitted in January 2015. I will keep you posted.

A lot of information can be gained from joining the HSCT group on Facebook, and the Russia HSCT treatment group also has a forum, but it is best to join both. The forum is moderated by two physicians so the information is accurate. And the support gained is invaluable! If you cannot find it, let me know. Lisa

Dear Lisa , may I ask how old you were when you had your stem cell transplant Im 55 but was only diagnosed at 50 I m in extremely good health apart from having MS Im terrified dr Federenko may not accept me , I dont want to get worse I still have a long time and a lot to look forward to in my life ,like becoming a grandmother in the not to distant future, thanks Lisa , I think I read somewhere that he had lifted the age and disability limit ?

My symptoms began at 54, diagnosed at 55 and HSCT at 56. I feel you are an excellent candidate, the earlier in your disease you receive treatment the better outcome. I suggest you contact him today. He is working on a paper and is out of the office for about 2 weeks. His wait list is one year, but well worth it. I asked to be admitted early if there were cancellations and I was! Also, check into joining the Facebook HSCT auto immune disease group, and the HSCT Russia forum for great info and support! Lisa

Thank you Lisa I have joined the group its a wonderful source of information , I have was and contacted George Goss as well, I get on it x

Hi Lisa, I am writing to you on behalf of my nephew, Matt, who is 35 and was diagnosed with PPMS about 7 or 8 years ago. His EDSS is currently 6.0. I have been doing extensive research about HSCT for him but he is hesitant. Can you offer any advice? He has a beautiful wife & 2 gorgeous little girls.

Join the Facebook group: Russia HSCT for MS and autoimmune diseases. A Lot of information to read in the files, contact info, and others who have been to Russia. It will be a tremendous help.

Hi Lisa, my partner has been suffering RRMS for approx 10 years. He has over the past month had his medication changed from injections to tablets due to his latest MRI showing he now has 2 lesions on his spine. We had made travel arrangements to attend Kristys seminar yesterday but had to cancel as Chris became very unwell which we have put down to the change in his meds. The new medication, Gilenya has had adverse side affects including severe headaches daily, severe constipation and a wave like feeling to add to his many symptoms of Ms. We are very interested in going to Russia for treatment and would like to go ASAP?? We attended The Sans Emergency dept Friday evening and were seen by a Dr who proceeded to ask what we wanted him to do for my partner? He went away and came back and asked the very same question a further 2 times!! Well by the third time, I blurted out, yes I know what you can do, RING CANBERRA HOSPITAL & DEMAND THAT THE COMMITTEE REINSTATE THE SCTP IMMEDIATELY!!!! He told us he could not help him and we left!

We do not want to wait until he gets more lesions and cannot walk. All info would be gratefully appreciated x Kind Regards Chris & Michelle Sydney

Join the Facebook group: Russia HSCT for MS and autoimmune diseases. A lot of information to read in the files, contact info, and others who have been to Russia. It will be a tremendous help. Lisa

I was diagnosed with primary progressive MS may 2010. My left leg is where it is bad I use stick. How do I go about getting HSCT. Paraic Heneghan

Join the Facebook group: Russia HSCT for MS and autoimmune diseases. A Loy of information to read in the files, contact info, and others who have been to Russia. It will be a tremendous help. Lisa

Do you know what other conditions he treats? Specifically, myalgic encephalomyelitis (CFIDS in the US). I tried the email to him directly but it failed.

I am not sure about that disease. Email him again in a few days. He has been inundated as a patient appeared on 60 Minutes, Australia. The mailbox is full, but he should be able to answer mail again soon.

Thank you. May I also ask how you got your diagnosis? I have been reading a comparison of MS and ME and they are almost identical in terms of symptoms and abnormal test results..I cant find a doctor. How did you find your doctor who diagnosed you?

It took a year and I went through two neurologists before I found one that was persistent. My MRIs did not have enhancing lesions. The diagnosis came through a lumbar puncture. It showed elevated igG synthesis rate, but no oligloconal bands. It takes one or both to confirm MS. I had every blood test in the book and two MRIs before they agreed to do the LP. Mine was so difficult as it came on suddenly and later in life than most MS cases, hence the PPMS diagnosis.

Hi Lisa I recently got diagnosed with MS and seriously considering the stem transplant procedure. Where do I start from?

Join the Facebook group: Russia HSCT for MS and autoimmune diseases. A Loy of information to read in the files, contact info, and others who have been to Russia. It will be a tremendous help.

Hi hi My name is Hanne And I am 45 years young. Soon to be 46 31.08.1968 I have had MS since April 1998 and I want to Take HSCT. My RRMS has been kind to me but there are a lot of things I cant do And I want to do everything Can you help me please Dr.F??? With love from Norway:-)))

Join the Facebook group: Russia HSCT for MS and autoimmune diseases. A Loy of information to read in the files, contact info, and others who have been to Russia. It will be a tremendous help. Lisa

Hi,

I am attempting to raise 40000 pounds to pay for HSCT treatment in Russia.

I plan to have coverage of my journey on local and national press.

I look forward to hearing from you.

Regards

Barry McArthur

Link:
Why Russia? | From Russia with Lisa...

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Stem Cell – Sino Biological Inc

Friday, September 30th, 2016

Stem Cells are characterised by their two properties of capability of renewing themselves and differentiating into a diverse range of cell types. The two broad types of mammalian stem cells are: embryonic stem cells and somatic or adult stem cells. Embryonic stem cells are isolated from the inner cell mass of blastocysts, while adult stem cells are found in adult tissues. In a developing embryo, stem cells can differentiate into all of the specialized embryonic tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, dividing essentially without limit to replenish specialized cells. Because of their pluripotency and unlimited capacity for self-renewal, embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease. Reprogramming of somatic cells with defined factors can be a resolution to the problem of allogeneic stem cell transplantation in embryonic stem cell therapies. Adult cells, which have been genetically reprogrammed to an embryonic stem celllike state by being forced to express genes and factors important for maintaining the defining properties of embryonic stem cells, are referred to as induced pluripotent stem cells (iPSCs).

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Stem Cell - Sino Biological Inc

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Stem Cell Therapy for Erectile Dysfunction with Angiogenesis

Monday, August 15th, 2016

Treatment for Erectile Dysfunction or ED is also called treatment for impotence. ED is generally defined as repeated inability to have or keep an erection for sexual intercourse. The actual term impotence can also be sometimes used to describe other physical issues that can interfere with regular sexual intercourse or reproduction. Erectile dysfunction is a very specific diagnosis that makes it clear that other problems such as premature ejaculation and emotional barriers are not involved. Often time our clients report damage to blood arteries, muscles,nerves or tissues in the reproduction area which usually lead to diagnosis of penile dysfunction. Stem Cells to treat EDcan help solve the issues naturally and at its root via non-surgical stem cell regeneration therapy.

Nearly 80% of all ED (Erectile Dysfunction) diagnosis can be attributed to the following medical conditions and are treatable with our stem cell treatment for erectile dysfunction:

Almost 62% of all men with Type 1 or 2 Diabetes experience some form of erectile dysfunction frequently. ED is usually a side-effect of a more serious health problem that can have a large impact on the happiness and overall quality of life for men and their sexual partners. Fortunately, thanks to modern medicine, there is finally hope for treatment using Stem Cells to treat Erectile Dysfunction. Please note that our doctors will look the treat the cause of your ED so any underlying medical conditions such as Diabetes would have to be treated first/alongside your treatment protocol for ED.

Pharma based treatments for ED are unsafe for long term use. Research has shown that popular oral PDE5 phosphodiesterase inhibitors are not effective over the long term and may cause serious side-effects or even sudden death (heart attacks). The failure of Pharmaceutical based PDE5 inhibitors is especially common for patients with diabetes who also have a sparing radical prostatectomy (non-nerve).

Not Again!

Clinical DiagnosisRequired

Today the treatment options for ED are mostly limited to hormone replacement therapy or other stimulant-based fixes that come loaded with negative side effects such as strokes,hypertension and heart diseases. These ED medications are also just a temporary fix and need to be taken throughout your entire life. The financial and physical costs associated with frequent hormone replacements or repeat use drugs such as Cialis or Viagra are a dangerous game of russian roulette. Researchers at the prestigious Cedars-Sinai Medical Center recently reported a high number of fatalities and negative cardiovascular events associated with the use of the drug Viagra. The College of Cardiologists also reported a total of 1,473 major adverse cardiac events last year in which almost 560 people died after taking ED medicine such as Cialis or Viagra (most from sudden heart attacks).

Your tolerance for these ED medicines will increase overtime requiring much higher doses to try to produce the same effects you had when you first took them. Our 2 step programis a permanent solution that will never require another pills again!

Today we are pleased to offer our clients a better solution with Stem Cell Erectile Dysfunction Treatment. Our unique therapy usesStem Cells from the patients own blood derived and/or adipose fat derived MSC stem cells.

Our Cell Therapiesworks to fix the root of the ED problem which is usually attributed to improper proper blood circulation in the penile area. Our Thai ED specialists have worked wonders by creating new blood vessels for our clients suffering though ED through a natural process called Angiogenesis. Angiogenesis or creating new blood vessels in the penis is very similar to the decades old cord blood stem cell therapyfor patients suffering from CAD ( coronary artery disease), CHF congestive heart failure,PAD or Peripheral Vascular Disease and cardiomyopathy. The medical data has proven that MSC CD34+ stem cells injected locally & through IV drip is very effective for near and long-term improvement in blood circulation,libido,sleep,appetite and an overall sense of well-being. The effects achieved with Thai Medical are permanent and are 100% safe and without any side-effects.

Previous research has proven the benefits forCell Therapy for ED and the data is substantiated in the scientific literature for stem cells of MSC mesenchymal origin. Your Blood and Fat are the most abundant source of MSC stem cells in the body. MSC stem cells from the blood can be easily extracted from your body and expanded in our state of the art stem cell lab, without any moral or ethical concerns. We do not use or offer embryonic derived or animal derived Live Cells for any stem cell treatment we offer.

The MSC stem cells can be harvested from your blood or fat without the need of any invasive surgery (as is required in bone marrow stem cells) and there is no risk of any rejection since the cells are Autologous (from your own body). Our unique stem cell treatment protocol calls for Expansion of your MSC stem cells that helps increase healing capacity by 200 to 300%.

To learn more aboutClinical Studies to treatErectile Dysfunction with Stem Cellspleasevisit the following government website:

Our Multi-StepTreatment for ED package requires 10-14nights in Bangkok. All of our stem cell treatments use the patients own stem cells (Autologous) without the need for any additional medicines or chemicals or hormones.

The Thai Medical Treatment for ED Overview:

Please note that not everyone is a good candidate for thestem cell therapies.Patients requesting treatments must be clinically diagnosed with ED form a urologist in their home or in Thailand. Patients with severe conditions or multiple dysfunctions that limit travel may also not qualify. Please contact us for more information.

The treatments require natural formation for blood vessels that normally takes 4-6 weeks to finalize after the initial treatment. The results for our natural treatment for ED are all permanent. Please note that your MSC stem cells can also be stored for over 20 years (additional cost) in our cryogenic stem cell bank in Bangkok. Your stored stem cells are essentially an insurance policy against any future injuries or diseases that occur naturally. Prices for our EnrichedCD34+ Stem Cell Transplants to treatErectile Dysfunction in Thailand depends on the patients medical needs especially if they have a pre-existing medical condition such as diabetes or heart disease. Our medical review takes 5-7 business days. Once the review is complete we can know for certain if the patient is a candidate and what the total and fixed medical costs will be. We can offer all-inclusive medical vacation packages that include hotels and transportation upon request. Please note this treatment is availablein Bangkok only.

TMV is a trusted organization that will help guide you every step of the way. Thai Medical groupoffer the most advanced non-surgical regenerative medical solutions in the Kingdom.Our stem cell doctors are all licensed by the Thai Medical board and we alsooffer assistance on many non-medical aspects of your medical tripat no additional cost.

The first step in your treatment is contacting us. We will respond to your inquiry in less than 24 hours and help you with the basic information needed such as estimated plan, travel details, and other necessary medically relevant information about having Stem Cell therapyto treat Erectile Dysfunction. To learn more please contact us today.

The Journey of a Thousand Miles Starts with a Single Step

HERE IS STEP ONE:

Request Medical Evaluation

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Stem Cell Therapy for Erectile Dysfunction with Angiogenesis

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Stem Cell Small Molecule Compound Library | Stem Cell …

Thursday, August 4th, 2016

High-throughput cell-based screening of drug library identifies albendazole as a sensitizer with combination of bortezomib for treatment multiple myeloma. [Kim MK, et al. Cancer Res 2014;74:1702 ]

A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells. [Thrane S, et al. Oncogene 2014;10.1038/onc.2014.351]

Patient-derived xenografts from non-small cell lung cancer brain metastases are valuable translational platforms for the development of personalized targeted therapy. [Lee HW, et al. Clin Cancer Res 2015;21(5):1172-82]

Kinome-level screening identifies inhibition of polo-like kinase-1 (PLK1) as a target for enhancing non-viral transgene expression. [Christensen MD, et al. J Control Release 2015;204:20-29]

Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway. [Bhardwaj V, et al. Oncotarget 2015;6(3):1531-43]

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer. [Franco J, et al. Oncotarget 2014;5(15):6512-25]

High-throughput Prescreening of Pharmaceuticals using a gGenome-wide bBacterial bBioreporter aArray. [Phillipson DW, et al. Biosensors and Bioelectronics 2015;68:699-704]

Overcoming acquired BRAF inhibitor resistance in melanoma via targeted inhibition of Hsp90 with ganetespib. [Acquaviva J, et al Mol Cancer Ther 2014;13(2):353-63]

Acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors. [Ember SW, et al ACS Chem Biol 2014;9(5):1160-71]

RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer. [Knudsen ES, et al. Cell Cycle 2015;14(1):109-22]

mTOR inhibition potentiates HSP90 inhibitor activity via cessation of HSP synthesis. [Acquaviva J, et al Mol Cancer Res 2014;12(5):703-13]

Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture. [de Wilde AH, et al. Antimicrob Agents Chemother 2014;58(8):4875-84]

Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery. [Ekins S, et al. PLoS Negl Trop Dis 2015;9(6):e0003878]

Aurora kinase A and B as new treatment targets in aromatase inhibitor-resistant breast cancer cells. [Hole S, et al. Breast Cancer Res Treat 2015;149(3):715-26]

Aurora kinases as druggable targets in pediatric leukemia: heterogeneity in target modulation activities and cytotoxicity by diverse novel therapeutic agents. [Jayanthan A, et al PLoS One 2014;9(7):e102741]

The Human Orphan Nuclear Receptor Tailless (TLX, NR2E1) Is Druggable. [Benod C, et al. PLoS One 2014;9(6):e99440]

Enhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian models. [Ekins S, et al. PLoS One 2013;8(5):e63240]

Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference. [Ansbro MR, et al. PLoS One 2013;8(4):e60334]

Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamoxifen resistant breast cancer. [Larsen SL, et al. BMC Cancer 2015;15:239]

Acetylation of intragenic histones on HPV16 correlates with enhanced HPV16 gene expression. [Johansson C, et al. Virology 2015;482:244-259]

Role of Kinase Epidermal Growth Factor Receptor and SRC in the Caerulein-Induced Acute Pancreatitis in Mice. [Huang Y, et al Pancreas 2014;10.1097/MPA.0219]

Synergistic apoptosis in head and neck squamous cell carcinoma cells by co-inhibition of insulin-like growth factor-1 receptor signaling and compensatory signaling pathways. [Axelrod MJ, et al Head Neck 2014;10.1002/hed.23822]

Pseudopeptides with a centrally positioned alkene-based disulphide bridge mimetic stimulate kallikrein-related peptidase 3 activity. [Meinander K, et al. MedChemComm 2013;4, 549-553]

Formation of covalently closed circular DNA in Hep38.7-Tet cells, a tetracycline inducible hepatitis B virus expression cell line. [Ogura N, et al Biochem Biophys Res Commun 2014;452(3):315-21]

Mass spectral similarity for untargeted metabolomics data analysis of complex mixtures. [Garg N, et al. International Journal of Mass Spectrometry 2014;10.1016/j.ijms.2014.06.005]

Bioinformatic mining of kinase inhibitors that regulate autophagy through kinase signaling pathways. [Yang Y, et al. Mol Med Rep 2014;10(6):3348-56]

From the biomolecular screening facility at the EPFL to the chemical biology screening platform for switzerland. [Turcatti G, et al. MedChemWatch 2013;Gerardo Turcatti]

Identification of kinases driving growth of anti-estrogen resistant T47D breast cancer cell lines. [Larsen SL, et al. Roskilde University 2013;Sarah Line Larsen ]

Selecting, acquiring, and using small molecule libraries for high-throughput screening. [Dandapani S, et al. Current Protocols in Chemical Biology 2012;4:177-191]

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