StemCell Therapy

OBJECTIVE:

To define the risk of coronary artery disease (CAD) in adults with a history ofjuvenile arthritis(JA) METHODS: We used the National Health and Nutrition Examination 2007-2014 Surveys. Two comparison groups were identified: 1) random sample withoutarthritis, and 2) respondents with reported rheumatoidarthritis(RA). Coronary artery disease was defined as yes to survey questions: Have you ever been told you had congestive heart failure, coronary heart disease, angina/angina pectoris, heart attack, or stroke? Potential confounders for CAD included age, gender, race, smoking status, and any component of metabolic syndrome.

There were 232 respondents who reported JA; 1,028 randomly selected withoutarthritis; and 1,105 who reported RA. In simple logistic regression, the JA group had a three -fold increased odds of CAD compared to those withoutarthritis(odds ratio (OR): 3.2, 95% confidence interval (CI): 2.1-4.8, p<0.0001). Controlling for confounders, the odds of CAD in JA continued to be increased (OR: 4.2, 95% CI: 4.7-10.5, p=0.002). When comparing the JA and RA groups, in simple logistic regression, the JA group had a lower odds of CAD (OR 0.7, 95% CI: 0.5-0.9, p=0.03). Controlling for confounders, there was no significant difference in odds of CAD between groups (OR 0.8, 95% CI: 0.5-1.3, p=0.4).

Adults with a history of JA have a higher risk of CAD compared to adults withoutarthritis. Providers should be aware of the increased risk of CAD in adults withjuvenile arthritisand aggressively screen these patients for modifiable risk factors.

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Coronary Artery Disease in Adults with History of Juvenile Arthritis - DocWire News

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