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The following article is part of conference coverage from the American College of Cardiology (ACC.20) /World Congress of Cardiology. The Cardiology Advisors staff is reporting on research conducted by leading experts in cardiology. Check back for the latest news from the ACC.20.

Thepresence of diabetes before liver transplantation may be an independentpredictor of sudden cardiac death after the procedure, according to studyresults intended to be presented at the American College of Cardiologys 69thAnnual Scientific Session.

Suddencardiac death has been recognized as a common type of cause-specific mortalityafter liver transplantation. To better understand the predictors of suddencardiac death, researchers prospectively collected data on clinical outcomesafter liver transplantation from 4538 adults who visited 6 centers in Australiaand New Zealand between 1985 and 2017 (median follow-up, 10.5 years).

Apanel of 2 cardiologists and a transplant physician assessed the cause of deathin this cohort, and cases of sudden cardiac death were defined as witnessedarrests or unwitnessed cases, in which patients were deemed to be healthy atthe last time of contact. In this cohort, there were 240 cardiovascular-relateddeaths (5.3%), of which 30.4% were categorized as sudden cardiac death. Suddencardiac death vs death with a different etiology occurred earlier after livertransplantation (7.5 vs 9.0 years, respectively; P =.03).

The presence of diabetes before liver transplantation was identified as an independent predictor of sudden cardiac death after adjusting for univariate predictors (ie, coronary artery disease, age, and steatohepatitis of nonalcoholic origin) in a multivariate regression analysis (hazard ratio, 2.5; 95% CI, 1.1-6.0; P <.001).

Studiesare needed to assess mechanisms of [sudden cardiac death] following [livertransplantation], and whether intensive risk factor modification in thepost-[liver transplantation] diabetic population improves survival,concluded the study authors.

Reference

Koshy AN, Gow PJ, Han HC, et al. Diabetes is an independent predictor of sudden cardiac death following liver transplantation: results from the Australian and New Zealand Liver Transplant Registry over 30 years. Intended to be presented at: American College of Cardiologys 69th Annual Scientific Session; March 28-30, 2020; Chicago, IL.

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Diabetes May Be an Independent Predictor of Sudden Cardiac Death After Liver Transplantation - The Cardiology Advisor

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