References
Abdelmohsen K, Panda A, Kang MJ et al. (2013) Senescenceassociated lncRNAs: senescenceassociated long noncoding RNAs. Aging Cell 12: 890900.
Anselmi CV, Malovini A, Roncarati R et al. (2009) Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study. Rejuvenation Research 12: 95104.
Atzmon G, Cho M, Cawthon RM et al. (2010) Evolution in health and medicine Sackler colloquium: genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proceedings of the National Academy of Sciences of the USA 107 (Suppl 1): 17101717.
Barzilai N, Atzmon G, Schechter C et al. (2003) Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA: The Journal of the American Medical Association 290: 20302040.
Beekman M, Blanche H, Perola M et al. (2013) Genomewide linkage analysis for human longevity: genetics of Healthy Aging Study. Aging Cell 12: 184193.
Beekman M, Nederstigt C, Suchiman HE et al. (2010) Genomewide association study (GWAS)identified disease risk alleles do not compromise human longevity. Proceedings of the National Academy of Sciences of the USA 107: 1804618049.
Bell JT, Tsai PC, Yang TP et al. (2012) Epigenomewide scans identify differentially methylated regions for age and agerelated phenotypes in a healthy ageing population. PLoS Genetics 8: e1002629.
Bonafe M, Barbieri M, Marchegiani F et al. (2003) Polymorphic variants of insulinlike growth factor I (IGFI) receptor and phosphoinositide 3kinase genes affect IGFI plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. Journal of Clinical Endocrinology and Metabolism 88: 32993304.
Bonafe M, Marchegiani F, Cardelli M et al. (2002) Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians. European Journal of Human Genetics: EJHG 10: 292296.
Boyden SE and Kunkel LM (2010) Highdensity genomewide linkage analysis of exceptional human longevity identifies multiple novel loci. PLoS One 5: e12432.
Campo S, Sardo MA, Trimarchi G et al. (2004) Association between serum paraoxonase (PON1) gene promoter T(107)C polymorphism, PON1 activity and HDL levels in healthy Sicilian octogenarians. Experimental Gerontology 39: 10891094.
Carrieri G, Marzi E, Olivieri F et al. (2004) The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians. Aging Cell 3: 443448.
Deelen J, Beekman M, Uh HW et al. (2011) Genomewide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell 10: 686698.
Deelen J, Beekman M, Uh HW et al. (2014) Genomewide association metaanalysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Human Molecular Genetics 23: 44204432.
Deelen J, Uh HW, Monajemi R et al. (2013) Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF1 signaling and telomere maintenance pathways. Age 35: 235249.
Eggertsen G, Tegelman R, Ericsson S, Angelin B and Berglund L (1993) Apolipoprotein E polymorphism in a healthy Swedish population: variation of allele frequency with age and relation to serum lipid concentrations. Clinical Chemistry 39: 21252129.
Flachsbart F, Caliebe A, Kleindorp R et al. (2009) Association of FOXO3A variation with human longevity confirmed in German centenarians. Proceedings of the National Academy of Sciences of the USA 106: 27002705.
Garatachea N, Emanuele E, Calero M et al. (2014) ApoE gene and exceptional longevity: insights from three independent cohorts. Experimental Gerontology 53: 1623.
Gaspari L, Pedotti P, Bonafe M et al. (2003) Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls. Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals 8: 522528.
Gombar S, Jung HJ, Dong F et al. (2012) Comprehensive microRNA profiling in Bcells of human centenarians by massively parallel sequencing. BMC Genomics 13: 353364.
Gro S, UtaDorothee I, Klintschar M and Bartel F (2014) Germline genetics of the p53 pathway affect longevity in a gender specific manner. Current Aging Science. doi:10.2174/1874609807666140321150751 (Epub ahead of print).
HalaschekWiener J, Vulto I, Fornika D et al. (2008) Reduced telomere length variation in healthy oldest old. Mechanisms of Ageing and Development 129: 638641.
Hannum G, Guinney J, Zhao L et al. (2013) Genomewide methylation profiles reveal quantitative views of human aging rates. Molecular Cell 49: 359367.
van Heemst D, Beekman M, Mooijaart SP et al. (2005a) Reduced insulin/IGF1 signalling and human longevity. Aging Cell 4: 7985.
van Heemst D, Mooijaart SP, Beekman M et al. and Long Life study g (2005b) Variation in the human TP53 gene affects old age survival and cancer mortality. Experimental Gerontology 40: 1115.
vB Hjelmborg J, Iachine I, Skytthe A et al. (2006) Genetic influence on human lifespan and longevity. Human Genetics 119: 312321.
Hurme M, Lehtimaki T, Jylha M, Karhunen PJ and Hervonen A (2005) Interleukin6 174G/C polymorphism and longevity: a followup study. Mechanisms of Ageing and Development 126: 417418.
Kerber RA, O'Brien E, Boucher KM, Smith KR and Cawthon RM (2012) A genomewide study replicates linkage of 3p2224 to extreme longevity in humans and identifies possible additional loci. PLoS One 7: e34746.
Kojima T, Kamei H, Aizu T et al. (2004) Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulinlike growth factor 1 signaling pathways. Experimental Gerontology 39: 15951598.
Lee JH, Cheng R, Honig LS et al. (2014) Genome wide association and linkage analyses identified three loci4q25, 17q23.2, and 10q11.21associated with variation in leukocyte telomere length: the Long Life Family Study. Frontiers in Genetics 4: 310.
Li Y, Wang WJ, Cao H et al. (2009) Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Human Molecular Genetics 18: 48974904.
Lio D, Scola L, Crivello A et al. (2002) Genderspecific association between 1082 IL10 promoter polymorphism and longevity. Genes and Immunity 3: 3033.
Lunetta KL, D'Agostino RB Sr., Karasik D et al. (2007) Genetic correlates of longevity and selected agerelated phenotypes: a genomewide association study in the Framingham Study. BMC Medical Genetics 8 (Suppl 1): S13.
Moskalev AA, Aliper AM, SmitMcBride Z, Buzdin A and Zhavoronkov A (2014) Genetics and epigenetics of aging and longevity. Cell Cycle 13: 10631077.
Murabito JM, Yuan R and Lunetta KL (2012) The search for longevity and healthy aging genes: insights from epidemiological studies and samples of longlived individuals. Journals of Gerontology Series A, Biological Sciences and Medical Sciences 67: 470479.
Nebel A, Kleindorp R, Caliebe A et al. (2011) A genomewide association study confirms APOE as the major gene influencing survival in longlived individuals. Mechanisms of Ageing and Development 132: 324330.
Newman AB, Glynn NW, Taylor CA et al. (2011) Health and function of participants in the Long Life Family Study: a comparison with other cohorts. Aging 3: 6376.
Noren Hooten N, Fitzpatrick M, Wood WH III et al. (2013) Agerelated changes in microRNA levels in serum. Aging 5: 725740.
Pawlikowska L, Hu D, Huntsman S et al. (2009) Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell 8: 460472.
Schachter F, FaureDelanef L, Guenot F et al. (1994) Genetic associations with human longevity at the APOE and ACE loci. Nature Genetics 6: 2932.
Sebastiani P, Bae H, Sun FX et al. (2013) Metaanalysis of genetic variants associated with human exceptional longevity. Aging 5: 653661.
Sebastiani P, Riva A, Montano M et al. (2011) Whole genome sequences of a male and female supercentenarian, ages greater than 114 years. Frontiers in Genetics 2: 90.
Sebastiani P, Solovieff N, Dewan AT et al. (2012) Genetic signatures of exceptional longevity in humans. PLoS One 7: e29848.
Soerensen M, Dato S, Tan Q et al. (2012a) Human longevity and variation in GH/IGF1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies. Experimental Gerontology 47: 379387.
Soerensen M, Dato S, Tan Q et al. (2013) Evidence from casecontrol and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity. Age 35: 487500.
Soerensen M, Thinggaard M, Nygaard M et al. (2012b) Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a crosssectional and longitudinal analysis. Aging Cell 11: 223227.
Stessman J, Maaravi Y, HammermanRozenberg R et al. (2005) Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study. Mechanisms of Ageing and Development 126: 333339.
Willcox BJ, Donlon TA, He Q et al. (2008) FOXO3A genotype is strongly associated with human longevity. Proceedings of the National Academy of Sciences of the USA 105: 1398713992.
Willcox BJ, He Q, Chen R et al. (2006) Midlife risk factors and healthy survival in men. JAMA: the Journal of the American Medical Association 296: 23432350.
Xia Y, Gueguen R, VincentViry M, Siest G and Visvikis S (2003) Effect of six candidate genes on early aging in a French population. Aging Clinical and Experimental Research 15: 111116.
Further Reading
Andersen SL, Sebastiani P, Dworkis DA, Feldman L and Perls TT (2012) Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span. Journals of Gerontology Series A, Biological Sciences and Medical Sciences 67: 395405.
Chang AL, Bitter PH Jr., Qu K et al. (2013) Rejuvenation of gene expression pattern of aged human skin by broadband light treatment: a pilot study. Journal of Investigative Dermatology 133: 394402.
Chung WH, Dao RL, Chen LK and Hung SI (2010) The role of genetic variants in human longevity. Ageing Research Reviews 9 (Suppl 1): S67S78.
Kahn AJ (2014) FOXO3 and related transcription factors in development, aging, and exceptional longevity. Journals of Gerontology Series A, Biological Sciences and Medical Sciences. doi: 10.1093/gerona/glu044 (Epub ahead of print).
LabatRobert J and Robert L (2014) Longevity and aging. Role of free radicals and xanthine oxidase. A review. PathologieBiologie 62: 6166.
Raichlen DA and Alexander GE (2014) Exercise, APOE genotype, and the evolution of the human lifespan. Trends in Neurosciences 37: 247255.
Rajpathak SN, Liu Y, BenDavid O et al. (2011) Lifestyle factors of people with exceptional longevity. Journal of the American Geriatrics Society 59: 15091512.
Seripa D, D'Onofrio G, Panza F et al. (2011) The genetics of the human APOE polymorphism. Rejuvenation Research 14: 491500.
Sevini F, Giuliani C, Vianello D et al. (2014) mtDNA mutations in human aging and longevity: controversies and new perspectives opened by highthroughput technologies. Experimental Gerontology 56: 234244.
Zhu H, Belcher M and van der Harst P (2011) Healthy aging and disease: role for telomere biology? Clinical Science 120: 427440.
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