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Home Colon And Digestive New research links Crohns disease to arthritis

New research published in Science Translational Medicine has revealed a bacterial link between Crohns disease and arthritis. Crohns is a form of inflammatory bowel disease, or IBD, that causes abdominal pain and diarrhea, and patients have also reported experiencing joint pain.

The immune system of patients with Crohns attacks the bowels and digestive system, but it can also target the musculoskeletal system and cause spondyloarthritis, resulting in spine and joint pain. This new research has found a link between the two conditions that may help explain why the immune system can turn its sights on the musculoskeletal system.

Researchers gathered fecal samples from patients with IBD and found that those with IBD and spondyloarthritis had a significant presence of E. coli bacteria in their samples. These samples, as well as mouse models, were used by the team to conclude that the E. coli bacteria was connected to the cells that help regulate inflammation in individuals with autoimmune disorders. Patients who had both Crohns disease and spondyloarthritis were found to have higher levels of these inflammation regulating cells, which are triggered by a protein known as IL-23.

These results have provided a target for potential treatments and medications, and with a better understanding of the inflammation caused by bacteria, scientists may be able to develop better treatment options to relieve the symptoms of Crohns and spondyloarthritis. They also open the door for the development of more personalized treatment regimens, as doctors may soon be able to address sources of inflammation specific to each patient.

Related Reading:

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http://news.weill.cornell.edu/news/2017/02/research-uncovers-bacteria-linking-crohn%E2%80%99s-disease-to-arthritis

Excerpt from:
New research links Crohn's disease to arthritis - Bel Marra Health

This entry was posted on February 13, 2017 at 2:41 pm and is filed under Arthritis. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed. |