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FOODS THAT FIGHT ARTHRITIS – Pune Mirror – Pune Mirror

May 21st, 2017 8:41 pm

By: Khushboo Thadani

Adding some items in your diet and reducing your intake of others will reduce inflammation and soothe joint pain

Often referred to as a single disease, arthritis is actually an umbrella term for more than 100 medical conditions. These conditions affect the musculoskeletal system, specifically joints where two or more bones meet. The three most common forms include osteoarthritis, fibromyalgia and rheumatoid arthritis.

Although it affects people of all ages, women and the elderly are most at risk. While regular physical activity, using assistive devices and hot/cold therapies are necessary, maintaining an anti-inflammatory diet will help manage the pain.

Add these to your diet:

Cruciferous vegetables: Vegetables such as broccoli, kale, cauliflower and cabbage contain the compound sulforaphane, which is known to block inflammation and damage to cartilage. These foods are also extremely alkalising and maintain the pH level of the blood. Over time, this will minimise the onset of inflammation. Broccoli and leafy greens also contain calcium, a mineral which helps maintain bone health and strength.

Nuts and seeds: These are a good source of polyunsaturated and monounsaturated fats, protein and antioxidants. Certain nuts are rich in magnesium, I-arginine and Vitamin E which keep inflammation in check. Walnuts and flaxseeds are particularly beneficial for arthritis sufferers.

Oily fish: Fish like salmon, tuna, sardines and mackerel have anti-inflammatory properties. They contain the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are absent in nuts and seeds. A source of lean protein, fish helps support cartilage and the repair of muscle tissue.

Red and purple fruits: Fruits like cherries, strawberries, blackberries, blueberries and raspberries contain anthocyanins. These powerful flavonoids help inhibit the production of certain inflammatory chemicals. These compounds also contribute to the health of connective tissue and defuse the attack from free radicals.

Turmeric: This spice contains the active chemical curcumin, an antioxidant with anti-inflammatory properties. To enhance the absorption of turmeric in the body, pair it with black pepper.

Pulses: Iron is important in preventing anaemia and many arthritis patients are anaemic. Along with leafy greens and red meat, pulses like lentils and chickpeas contain a significant amount of iron. The body absorbs iron better when consumed with Vitamin C so pair it with citrus fruits, broccoli etc.

Avoid these:

Red meat: The fat in red meat is highly acidic and readily metabolised into inflammatory chemicals that cause swelling and painful inflammation in the joints. The saturated fat in animal protein also damages cartilage and joints.

Sugar and refined carbohydrates: Blood sugar levels surge after consumption of such foods, prompting the body to produce pro-inflammatory chemicals called cytokines.

Junk food: The sodium in such foods promotes water retention. Swollen veins put pressure on inflamed joints, aggravating the pain of sufferers.

Dairy: Although a good source of protein, dairy products are extremely inflammatory. Instead, opt for plant-based sources of protein such as beans, legumes and whole soybean products (like edamame and tofu, for example).

The writer is a Mumbaibased nutritionist and dietician

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Diabetes steadily increasing in Sarasota schools – Sarasota Herald-Tribune

May 20th, 2017 11:51 pm

Yadira Lopez @yadiralopezht

The number of K-12 students with diabetes in Sarasota County schools has increased by 50 percent since 2011, according to figures from the Florida Department of Health in Sarasota County.

In 2011, 83 students were identified as diabetic in county schools. That number jumped to 128 in the current school year. The steadily growing rate has put increased pressure on school health services, said Suzanne DuBose, a registered nurse and supervisor of health services in Sarasota County schools.

Having a student with diabetes frequently increases the number of health room visits since these students typically visit the school clinic two to three times per day, DuBose said.

Type 1 diabetics, who make up the bulk of the countys diabetic students, require lifelong daily insulin injections. In schools, the shots are required to be administered by registered nurses. But Sarasota County does not have a full-time RN at every school, relying instead on RNs that travel throughout the district.

There are few recent studies on the prevalence of diabetes in kids, but according to the National Institutes of Health, as obesity rates in children continue to soar, type 2 diabetes, a disease that used to be seen primarily in adults age 45 and older, is becoming more prevalent among children.

A study funded by the Centers for Disease Control and the NIH found a 20 percent jump in type 2 cases between 2001 and 2009. Researchers called the increase substantial, and most experts agree that growth is due to weight and sedentary lifestyles.

While studies have shown an increase in the number of children diagnosed with type 1 diabetes, most researchers agree that there is no single cause, DuBose said. Genetics plays a role, but exposure to certain environmental factors may also trigger the disease.

The most important thing parents can do is to watch for symptoms of type 1 diabetes such as frequent urination, thirst and weight loss, she added. The earlier its detected, the better.

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Local girl tapped for diabetes event | News | The Press and Standard – Walterboro Live

May 20th, 2017 11:51 pm

by The Press and Standard | May 20, 2017 5:00 am

Last Updated: May 17, 2017 at 12:27 pm

By JULIE HOFF

widdleswife@aol.com

Cameron Shephard has Type 1 juvenile diabetes, but it doesnt have her.

She tackles the disease with matter-of-fact confidence, and has since she was diagnosed at age 7.

Cameron, now 13, is the daughter of David and Lisa Shephard of Givhans. Lisa is a nurse at Colleton Medical Center.

Theres no family medical history [of diabetes] whatsoever, as far back as we know, Lisa said. Cameron has two older brothers, Kaleb and Blake, neither of whom has diabetes.

Cameron, who attends Gregg Middle School in Summerville, doesnt let the disease slow her down. Shes maintained a place on the honor roll while taking advanced classes in elementary and middle school. Shes in the Gifted And Talented Education (GATE) program and a member of the Junior Beta Club. She plays tennis at Gregg, and I like to play outside with my brother Blake basketball or football, she said.

In the six years since her diagnosis, Cameron has had more than 15,000 needle injections and eight hypoglycemic seizures, Lisa said.

Counting carbs and testing her blood sugar several times a day is just a fact of life, and she doesnt complain.

She does great with it. She never lets it get her down, Lisa said

I dont really remember before [the diagnosis], Cameron said. Its just my life.

Lisa became an advocate for diabetes research and education. She and Cameron met with Congressmen James E. Clyburn and Mark Sanford and participated in a 100-mile fundraising bike ride to benefit the Juvenile Diabetes Research Foundation. In addition, Cameron has organized a JDRF Walk Team for five years.

Now Cameron has been selected to represent South Carolina in the JDRF Childrens Congress this summer in Washington, D.C. Approximately 1,500 youths applied for 155 slots, Lisa said. Two other S.C. delegates, from Greenville and Columbia, were also selected.

They fill out an application and write a letter to their congressman, and they look at their grades and any work theyve done to support advocacy and research, Lisa said.

During the Congress, which is held every other year, kids learn leadership skills, make friends and talk to elected leaders about the importance of government funding for juvenile diabetes research.

Cameron began to exhibit classic symptoms of the disease at age six. She was drinking a lot of fluids and having to use the bathroom constantly. Then she started getting extremely sleepy we were in denial, Lisa said.

They went to Dr. Benjamin Rogers at Edisto Pediatrics, and I packed a suitcase for her before we even left. I knew she wasnt coming back home that night, Lisa said. When Cameron was weighed, her parents realized how much weight shed lost. And her blood sugar was over 800 dangerously high.

Rogers sent the family to the Medical University of South Carolina, where Cameron quickly learned the routines associated with her disease.

Before we even left the hospital she was able to stick her own finger and get her blood sugar numbers, Lisa said.

Today Cameron checks her blood sugar three or four times a day. She wears a device called a CGM, a continuous glucose monitor, which downloads her blood sugar levels every five minutes to her phone.

Every three or four days, we have to change the insulin pump to a new site, and once a week we change CGM sites, Lisa said. The pump constantly infuses insulin 24 hours a day. It tells her if she needs insulin or not. When she eats, she has to count how many carbs shes eating and she has to enter those numbers into the pump.

None of it fazes Cameron. Shes focused on two things: Finding a cure for those who have been diagnosed, and early diagnosis for those who have it.

We are very proud of Cameron for being selected to represent our state, and of how well she lives with this chronic disease that has no days off, Lisa said.

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Aging cells are key to finding Fountain of Youth – Jerusalem Post Israel News

May 20th, 2017 11:48 pm

Jerusalem Post Israel News
Aging cells are key to finding Fountain of Youth
Jerusalem Post Israel News
... organism as a whole and on specific age-related diseases. A few age-related diseases account for most of the causes of death in old people. Senescent cells accumulate in premalignant lesions, sites of tissue damage and in normal tissues during aging.

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The Doctor finally reveals his blindness in trailer for next week’s ‘Pyramid at the End of the World’ – DigitalSpy.com

May 20th, 2017 11:47 pm

Warning: this article contains spoilers from Doctor Who episode 'Extremis'.

After this week's confusing Doctor Who episode 'Extremis', it seems that the Doctor, Bill and Nardole are heading to more challenging terrain next week.

In a trailer for 'The Pyramid at the End of the World', we see the trio visit a 5,000-year-old pyramid.

Except there's a problem the structure was not there the previous day, and the creatures inside have been studying the people around it to arrive at that exact time.

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Related: Doctor Who series 10, episode 6: 8 HUGE questions and theories after watching 'Extremis'

Oh, and it looks like the Doctor may finally reveal the truth about his blindness, which would be good, eh Doctor?

Those shadow creatures from this week's episode are also back, and they seem to be as doomy as ever.

Meanwhile, 'Extremis' finally saw the return of fan favourite Missy after a series or so away from our screens.

BBC

Related: Doctor Who series 10, episode 6 review: 'Extremis' gets lost in the dark

We also learned what was inside the vault, in that the Doctor had actually been holding Missy inside the whole time a secret that was revealed within the first five minutes.

Doctor Who returns on BBC One next Saturday (May 27) with 'The Pyramid at the End of the World'.

Want up-to-the-minute entertainment news and features? Just hit 'Like' on our Digital Spy Facebook page and 'Follow' on our @digitalspy Twitter account and you're all set.

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Smaller Version of Skill Injectors & Color Blindness Support – MMORPG.com

May 20th, 2017 11:47 pm

The EVE Online site has been updated with the news that Skill Injectors are getting a new, smaller version in addition to the current one. The smaller Skill Injector will weigh in about 1/5th the size of the already-existing one and will, of course, come at a lower cost, perfect for newer and beginning players.

At the current time, Skill Injectors cost about 650M ISK, a cost prohibitive to new players. By adding the smaller injector, more players early in their time within EVE will have an opportunity to make use of them.

You can read the full blog post on the EVE Online site.

In other EVE news, color-blindness support is coming to the game!

[A]round 7.999% of EVE players are color blind, which is a considerable chunk. I am not one of those 7.999%, so it was particularly interesting, yet challenging, to work on this feature, mostly because I was at no point capable of estimating if I was finding any success. I guess that gave me a tiny taste of how it must feel to be colorblind.

You can read more about how support was designed here.

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iShares NASDAQ Biotechnology Index (IBB) Upgraded to "Buy" at Vetr Inc. – The Cerbat Gem

May 20th, 2017 11:47 pm

BBNS
iShares NASDAQ Biotechnology Index (IBB) Upgraded to "Buy" at Vetr Inc.
The Cerbat Gem
iShares NASDAQ Biotechnology Index logo iShares NASDAQ Biotechnology Index (NASDAQ:IBB) was upgraded by research analysts at Vetr from a hold rating to a buy rating in a note issued to investors on Tuesday, April 18th. The firm currently has a ...
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Vetr Inc. Upgrades iShares NASDAQ Biotechnology Index (IBB) to BuyTranscript Daily
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Foods that fight arthritis – Mumbai Mirror

May 20th, 2017 11:47 pm

By Khushboo Thadani

Adding some items in your diet and reducing your intake of others will reduce inflammation and soothe joint pain.

Often referred to as a single disease, arthritis is actually an umbrella term for more than 100 medical conditions. These conditions affect the musculoskeletal system, specifically joints where two or more bones meet. The three most common forms include osteoarthritis, fibromyalgia and rheumatoid arthritis. Although it affects people of all ages, women and the elderly are most at risk. While regular physical activity, using assistive devices and hot/cold therapies are necessary, maintaining an anti-inflammatory diet will help manage the pain.

Add these to your diet:

Cruciferous vegetables: Vegetables such as broccoli, kale, cauliflower and cabbage contain the compound sulforaphane, which is known to block inflammation and damage to cartilage. These foods are also extremely alkalising and maintain the pH level of the blood. Over time, this will minimise the onset of inflammation. Broccoli and leafy greens also contain calcium, a mineral which helps maintain bone health and strength.

Nuts and seeds: These are a good source of polyunsaturated and monounsaturated fats, protein and antioxidants. Certain nuts are rich in magnesium, I-arginine and Vitamin E which keep inflammation in check. Walnuts and flaxseeds are particularly beneficial for arthritis sufferers.

Red and purple fruits: Fruits like cherries, strawberries, blackberries, blueberries and raspberries contain anthocyanins. These powerful flavonoids help inhibit the production of certain inflammatory chemicals. These compounds also contribute to the health of connective tissue and defuse the attack from free radicals.

Oily fish: Fish like salmon, tuna, sardines and mackerel have antiinflammatory properties. They contain the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are absent in nuts and seeds. A source of lean protein, fish helps support cartilage and the repair of muscle tissue.

Turmeric: This spice contains the active chemical curcumin, an antioxidant with anti-inflammatory properties. To enhance the absorption of turmeric in the body, pair it with black pepper.

Pulses: Iron is important in preventing anaemia and many arthritis patients are anaemic. Along with leafy greens and red meat, pulses like lentils and chickpeas contain a significant amount of iron. The body absorbs iron better when consumed with Vitamin C so pair it with citrus fruits, broccoli etc.

Avoid these:

Red meat: The fat in red meat is highly acidic and readily metabolised into inflammatory chemicals that cause swelling and painful inflammation in the joints. The saturated fat in animal protein also damages cartilage and joints.

Sugar and refined carbohydrates: Blood sugar levels surge after consumption of such foods, prompting the body to produce pro-inflammatory chemicals called cytokines.

Junk food: The sodium in such foods promotes water retention. Swollen veins put pressure on inflamed joints, aggravating the pain of sufferers.

Dairy: Although a good source of protein, dairy products are extremely inflammatory. Instead, opt for plant-based sources of protein such as beans, legumes and whole soybean products (like edamame and tofu, for example).

The writer is a city-based nutritionist and dietician

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Mouse study looks at safety of stem cell therapy for early … – Science Daily

May 20th, 2017 11:46 pm
Mouse study looks at safety of stem cell therapy for early ...
Science Daily
Now that we know that egg-making stem cells exist in adults and that these cells can be transplanted into mice with premature ovarian failure to produce ...

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Sight-impaired get guide-dog tryouts – The Blade – Toledo Blade

May 20th, 2017 4:48 am

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Walking briefly with a black Labrador retriever named Robin solidified Chris Halls idea into a goal.

The Findlay man craves independence, but has lost nearly all vision the last three years because of advanced glaucoma. He recently has been considering getting a guide dog to help him navigate the world.

Butts

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Before I lost my eyesight, I was very active, he said. Now, I cant go anywhere, really, unless Im with my wife. I want to be able to let go of her and walk myself.

The Sight Center of Northwest Ohio hosted a workshop Friday with the Guide Dog Foundation, based in New York. Representatives of the foundation brought several dogs, answered a slew of questions, and let about 20 attendees experience walking with a guide dog.

It gives them a better idea of what a dog can do, what a dog cant do, and whats involved in getting a dog, Greg Levick, a field representative for the foundation, said.

Stacey Butts, executive director of the center, said staff often field questions about guide dogs. The workshop the centers second such event gives people a chance to ask the experts, experience what its like to walk with a dog, and decide what their mobility preferences may be.

People walk out with a pretty good feeling if its something they want to pursue, she said.

Mr. Hall now walks with a cane, which he said is slow and sometimes challenging. Walking with Robin felt more natural, and hes now decided to pursue getting a dog of his own.

Christopher Hall, left, learns how to hold the harness of Robin, a Labrador retriever, from Greg Levick, from the Guide Dog Foundation.

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Its going to be much faster with a dog, he said. I can get out and do things.

Ms. Butts said a person must first be proficient with a cane before getting a guide dog because the canine is not always going to be able to accompany its handler. A dog can get sick or injured, need a break, or just be problematic to bring along.

Brandi Shepard of Sylvania, a teacher at Southview High School, has only 8 to 20 degrees of vision in one eye. For now, shes doing well and doesnt use a cane, but attended the event in preparation for losing more of her vision.

After walking with one of the guide dogs at the workshop, she decided to hold off on obtaining one of her own.

Giving up that complete control to the dog is both liberating and frightening at the same time, she said. At this point, having the vision I still have, I dont think I could give up that control yet.

Ms. Butts said guide dogs can make a person more visible, helping increase safety for someone with vision impairment.

Someone might not notice a white cane, but everyone notices a dog, she said.

Mr. Levick noted handlers also will have to learn how to deal with people who want to pet or otherwise interfere with their guide dogs, as well as people who dont know the law regarding public access rights for service animals. The dogs also require daily care and ongoing training.

There are difficulties and challenges that come with it, Ms. Butts said. So its really a preference, whatever someone is comfortable with.

Contact Alexandra Mester:amester@theblade.com,419-724-6066, or onTwitter @AlexMesterBlade.

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EAT WELL TO BE WELL: Two nutrients necessary to keep a sharp mind and clear eyesight – Osage County Herald-Chronicle

May 20th, 2017 4:48 am

When it comes to nutrients protecting and maintaining eye and brain health, there are two words everyone should be familiar with - lutein and zeaxanthin. This twosome are key nutrients that have substantial evidence-based science indicating the role they play in keeping two very important organs the eyes and the brain - healthy and working their best. Eye health is one of the most undervalued but important aspects of our overall health, said Dr. David Samadi, chairman of urology and chief of robotic surgery at Lenox Hill Hospital in New York City. He went on to explain, Its important for patients not to neglect their vision health, as eye disorders can be quite debilitating, such as inflammation of the eyelids, blurry vision and even cataracts. There are many things you can do to keep them healthy and make sure youre seeing your best.

What are lutein and zeaxanthin Lutein and zeaxanthin are members of xanthophyll carotenoids which are part of more than 600 naturally occurring pigments found in nature that are the sources of the red, yellow, and orange colors of many plants. The human body cannot make them on its own and less than 20 of the over 600 carotenoids are found in the human body. Together, lutein and zeaxanthin have impressive antioxidant potential for eye health and now promising potential for cognitive or brain health.

Their role in eye health Its been known for many years that lutein and zeaxanthin are important for helping to lower the risk of age-related macular degeneration (AMD). AMD is a chronic eye disease affecting more than 15 million American adults that gradually destroys the macula. The macula is a small region in the retina a light sensitive tissue lining the back of the eye thats responsible for clear central vision. It leads to an irreversible vision loss in the center of the field of vision but without affecting peripheral vision. The center field of view will appear blurry, distorted or dark and is like placing your fist at the bridge of your nose creating a blind spot, making it difficult to read, drive, do any close-up work or recognize faces. AMD is the number one cause of severe vision loss and legal blindness of people over the age of 60 in the U.S. Out of all the carotenoids present in the body, only lutein and zeaxanthin are found in the retina and in high concentrations in the macula of the retina. This is important as lutein and zeaxanthin filter harmful high-energy blue wavelengths of light and act as antioxidants in the eye, helping to protect and maintain healthy cells from environmental and light-induced oxidative damage caused by smoking, pollutants and sun exposure. Two research studies over the years have provided convincing evidence of the vital role lutein and zeaxanthin play in helping to prevent or slow the progression of AMD. The first study occurred back in the 1990s which was a large, randomized clinical trial conducted by the National Institutes of Healths National Eye Institute. This study oversaw the Age-Related Eye Disease Study (AREDS). Then a second study was completed in 2013 (AREDS2) that confirmed the role of supplements in preventing advanced AMD. The study used a formulation of high-dose antioxidants that showed a 25% reduction risk of developing advanced AMD and a 19% lower risk of central vision loss of people with intermediate or advanced disease. The two nutrients that stood out from the others were lutein and zeaxanthin. Both AREDS and AREDS2 studies used supplementation of lutein at 10 mg a day and supplementation of zeaxanthin of 2 mg a day. Currently, there is no recommended daily intake for lutein or zeaxanthin. However, to lower the risk of AMD, research has shown it takes at least 6 mg of lutein each day but the average adult takes in less than 2 mg of lutein a day.

Their role in brain health In recent years, it appears that lutein and zeaxanthin may now be useful in maintaining cognitive function in the elderly. Data from various studies have supported the importance of lutein and zeaxanthin in brain health. Like the eye, lutein is the predominant carotenoid in the brain and is absorbed by the brain more than any other carotenoid. Years of oxidative stress and inflammation can make the brain vulnerable to decreases in cognitive functioning. What may help are dietary antioxidants and anti-inflammatory agents that delay oxidative damage to the brain. Lutein and zeaxanthin function as both an antioxidant and anti-inflammatory agents in order to maintain proper brain functioning. Data from a double-blind, placebo-controlled study provided valuable information, particularly on luteins role in brain health. The study used healthy older women and results showed those who received 12 mg of lutein along with 800 mg of DHA (an omega-3 fatty acid) per day were found to have improved verbal fluency, memory scores and a higher learning rate after 4 months. This study helped to support the role carotenoids like lutein and zeaxanthin along with DHA working together synergistically, can improve brain health. Research has also confirmed that the amount of carotenoids like lutein and zeaxanthin in the brain are related to the amount of these same carotenoids found in the macula of the retina of the eye. Therefore, the more lutein and zeaxanthin concentrations found in the macula, this most likely reflects higher lutein and zeaxanthin concentrations in the brain which could mean higher cognitive functioning.

Nutritions role in eye and brain health At this time it is encouraged for people to consume more carotenoid-rich foods that contain lutein and zeaxanthin to maintain and possibly prevent developing AMD or decreased cognitive functioning. If it is difficult for a person to eat foods rich in lutein and zeaxanthin, then a supplement containing both is recommended. Beta Carotene is a carotenoid compound and in particular has long been known to be a big defender against the risk of disease, particularly certain cancers and eye disease, added Dr. Samadi. Perhaps the connection stems from beta carotene also being linked to aging which many eye diseases develop as a result of. This nutrient is what makes the pigment in fruits and vegetables orange or red. Think tomatoes, sweet potatoes, squash, red peppers and even dried apricots. Why does it help lower the risk of disease? Because it makes these foods a powerful antioxidant that help fight inflammation and we know this is the most important diet factor we can have, especially early on in life.

Best food sources of both lutein and zeaxanthin:

USDA National Nutrient Database Here are some ideas to help increase food intake of lutein and zeaxanthin: The dark green leafy vegetables can be eaten raw if preferred. Try to consume at least a couple of the above foods daily Dont like the taste? Blend them with other foods in a smoothie Discuss with your physician or optometrist on nutritional supplements containing lutein or zeaxanthin

In conclusion None of us want to develop AMD or have decreased cognitive function as we age. The good news is we can take nutritional preventative measures that can help avoid or at least delay any progression taking place. Dr. Samadi added further, Its interesting how eye and brain health are directly connected, which therefore leads to nutrition and diet habits that can keep both vital organs working at their most optimal. Remember the words lutein and zeaxanthin they may just be the key to more clear thinking and eyesight in the future.

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Ottawa girl, facing vision loss, to take in the City of Light – CBC.ca

May 20th, 2017 4:48 am

Jayden Lanning is leaving on a 10-day trip Friday to see the Eiffel Tower in Paris, to gaze at the iconic landmark as its gold lights sparkle at night. If the skies are right later during a stop inIceland, the 11-year-old Ottawa girl may also get to see the Northern Lights, too.

If she's going to go blind, Jayden wants to see the best the world has to offer.

Lanning's parents, Steve and Belinda, adopted Jayden as a baby, andlearned when she was two months old thatshe was deaf.

By coincidence, Belinda Lanning is a sign language interpreter. After teaching Jayden to sign, getting her cochlear implants and intensive speech therapy, her parents thought they had things under control.

Jayden, Belinda, Alena and Steve Lanning outside of their Ottawa home. Their trip is all about seeing the sights through the eyes of their children. (Ashley Burke/CBC)

Then, when she was nine, theylearned she had Usher syndrome, a condition that affects some three to six per cent of children who are deaf and leads to balance and vision issues. In the most serious cases, like Jayden's, it could leadto total blindness. There is currently no cure for Usher syndrome.

"We recognize time is precious," said Belinda Lanning. "We want that filing cabinet in her mind to be full of all sorts of memories so that if she's faced with the future of total blindness, that she has so much to still live in her mind and see still."

Jayden has little peripheral vision. When she looks at objects up close, it's like looking through a circle the size of a golf ball. That tunnel vision could close in entirely during her teen years, her doctors say.

"You get choked up even thinking about it," said her father Steve. "It's tough I just can't fathom really, going without your eyesight."

It was during a heart-to-heart with her daughter not long after they learned she would likely lose her visionthat Belinda asked Jayden what she wanted to see before she lost her sight, and her daughter said the Eiffel Tower.

"I thought that was amazing," said Belinda. "I would have not expected she would have said that. It blew me away."

Jayden is a creative preteen who loves to draw in vivid colours, is interested in fashion, and often gets lost in a good book. Paris is a place she's read all about.

Jayden was diagnosed with Usher syndrome at the age of 9. Her parents had suspected for years that was why her balance was off. (Ashley Burke/CBC)

"I thought it'd be a really interesting place to see," saidJaydenof Paris.

"It seems like it would be really cool to see at night with all the lights, lighting up the entire city. Just seeing it glow."

When Jayden's school, church and friends learned about her wish, they rallied to turn her dream into a reality.

The Ottawa Christian School threw a Paris-themed movie night where kids ate popcorn and parents went out for a date night.

Belinda says their family's faith has given them strength. (Ashley Burke/CBC)

The school also helped bake more than 150 pies to raise money with the Barrhaven Fellowship church the Lannings attend. A crowd-funding campaign brought in more support from friends, family, even strangers around the world.

Six months later, the community raised more than $15,000 for the Lannings' one-of-a-kind trip.

"I feel like it's really kind and generous," said Jayden. "It's so special, because lots of people planned it all out for us."

The Lannings will travel Paris for a week to gaze at theEiffel Tower at day and night and take in the other sights.

On the way home, they're stopping over inIceland with hopes Jayden and her six-year-old sister Alenawill see another spectacular light show.

"They say in Iceland the Northern Lights light up the sky with colour," said Steve. "That's what we want her to see."

Steve Lanning said during the day Jayden has been incrediblystrong. It's only every few months at night, when her implants are off and she can't hear, that she voices her fears and sometimes calls outto her parents.

Jayden loves to draw colourful pictures, write in her notebook and get lost in books. (Ashley Burke/CBC)

"Sometimes it's just a question am I ever going to be able to drive?" said Belinda."Sometimes it's just I'm scared I'm going blind and not going to be able to do things other kids can do. Sometimes it's just needing an extra hug."

Since Jayden can't hear at night, her parents write back and forth to her on an erasable dry board. Message after message, they calm her fears.

No matter what happens next, Jayden's family wants her to keep positive.

"She's always going to be surrounded by love no matter what," said Belinda. "We have lots of dreams for her and those dreams haven't changed.

"She's been through a lot and keeps smiling. She has a lot going for her no matter what happens."

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Danish project really may give eyesight to the blind – The Copenhagen Post – Danish news in english

May 20th, 2017 4:48 am

What do solar cells and blindness have in common?

Rasmus Schmidt Davidsen, a post-doctoral researcher at Danish Technical University (DTU), hopes to develop an implant containing thousands of small isolated solar cells thatcan be placed behind the retina of blind patients to give them their sight back.

There are over 2 million people worldwide who are blind because the photoreceptors in their eyes dont work properly. The function of photoreceptors is to absorb light and send electronic impulses to the brain. When the patient doesnt receive these impulses, he or she experiences blindness.

READ ALSO: The Danish app that lends eyes to the blind

Davidsen explained that the eyes photoreceptors behave very much like solar cells, so the team got the idea that they could use some of the expertise that he has from the field of solar cells to make a chip for blind people. Each solar cell would be the equivalent of 1 pixel in the artificial vision they are trying to create.

Getting enough light One of the first challenges is to get enough power from natural light.

Even the best solar cells are unable to generate enough power based on natural light, saidDavidsen.

We are also limited to an area of 3 x 3 millimetres into whichthe surgeon can insert the chip. We cant even use the entire area because there also has to be electrodes and holes so that tissue fluids can flow freely into the eye.

The light problem has fortunately been solved by other researchers who found that, for example, the light source can be installed in glasses such as those used in Google Glass.

At the moment, the team are working with fresh eye tissue from pigs supplied by Danish Crown. At the moment, were working on the first prototype implant. Time will tell whether it will be possible to detect a reaction from the nerve cells from the pigs eyes.

A promising but challenging project A senior doctor and clinical professor at the eye department of Aarhus University Hospital, Toke Bek, who is co-operating with DTU, has high hopes for the project but can also see many challenges ahead.

One of them is biocomplexity. It is quite likely that the tissue will reject foreign bodies, especially in the eye. But nano-technicians can make an implant that can be encapsulated into material that the tissue cant easily reject. And they can make it very small.

He added that the solar cells are able to make use of nearly 100 percent of the light.

All in all, it makes sense to continue work on the project. There are considerable advantages working in co-operation with DTU, Bek added.

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Danish project really may give eyesight to the blind - The Copenhagen Post - Danish news in english

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Local boy with eye disease needs help getting device to see – FOX 29 News Philadelphia

May 20th, 2017 4:48 am

Perkasie, Pa. (WTXF) - A local boy with an eye disease needs help getting a device to see.

13-year old Andrew Lowe or AJ is what he likes to be called, is like many teens. He enjoys watching TV, playing card games and he likes sports.

I dropped in on him at a wrestling club in Hilltown where he goes during the off season when he's not wrestling for his school team. He revealed to me why over the past two years he's developed a passion for wrestling.

"It's pretty much the one sport I can do. It's a close up sport," he said. AJ's eyesight is the reason he's limited in many areas not just sports. His mom Julie explains.

"Just being able to say hi to people walking down the hall, by the time he can probably recognize your face, you're already walking by him. We'll send him to the kitchen to find the bananas and he'll be in there five minutes looking around," she said. Thats because AJ has Stargardt disease. Its a kind of juvenile macular degeneration. It's progressive and will eventually completely take away his central vision and there's no cure. Greg Lowe says his son was diagnosed three years ago.

"Imagine not being able to see anything in the center of your vision where you have just blank spots or scratchy film over everything you see. Like looking through a lace curtain. How difficult that must be," said AJs father. But now there's hope through E-sight. Its a device that gives some sight to certain people who are legally blind. An E-sight rep came to AJs house for him to try it out. His mother gets emotional talking about the moment they realized it worked for him.

"My husband was sitting across the table and Andrew saw Greg and a smile crossed his face and he said I can see you dad. Im sorry, said Julie as she teared up. AJ says, It was surprising that I could actually see my parents face which I haven't seen in like four years and it was very nice. I could actually read some books.

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Local boy with eye disease needs help getting device to see - FOX 29 News Philadelphia

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Floored by diabetes diagnosis, Richard Fink fought back – Buffalo News

May 20th, 2017 4:47 am

Richard Fink was an All-High first baseman who weighed about 165 pounds when he played for the Bennett High School baseball team during the mid-1970s. He spent the 1980s and 90s playing Muni and suburban hardball with teams based near his Getzville home, as well as pickup basketball up to three times a week.

Im very competitive, he said.

Fink, 62, has worked the last three decades as a legal process server. Over the years, he spent a growing amount of time behind a desk or the wheel of a car. He ate lots of food on the go and enjoyed his share of the standard Buffalo diet: breakfast sandwiches, chicken wings and pizza.

The nearly 6-foot-tall Fink weighed 215 pounds when a case of pneumonia knocked him off his feet for two months early last year. He packed on another 15 pounds as he recovered.

Meanwhile, his blood sugar level crept into the diabetes range.

Ive played sports my whole life, so when youre diagnosed with diabetes its a shock, he said.

[BELOW: Diabetes ABCs, key prediabetes and diabetes test levels]

Fink was not at all comfortable joining the legion of 115 million Americans roughly one in three with diabetes or prediabetes. His primary care doctor put him on the oral medication Metformin and helped him understand the dangers unaddressed high blood sugar levels can bring: poor circulation that boosts the risk of blindness and kidney failure, heart attack, stroke and limb amputation.

Fink was floored.

If scientists tell you that you can go blind looking at the sun during an eclipse, you dont look. Its an immediate reaction, he said. But if it comes down to eating or other choices, its OK, because nothing happens immediately to you. But then, 20 years later, that accumulation of poor eating habits and behavior, it catches up with you. The bill comes due.

Fink decided to beat back diabetes. Heres how.

Start with a plan

Richard Fink, left, pledged to amp up his weekly workout regimen and change his diet after he was diagnosed with diabetes. (Robert Kirkham/Buffalo News)

Fink started his Type 2 diabetic journey last spring after lab tests showed his fasting blood sugar level at 338 milligrams per deciliter, more than three times the normal level. His A1C reading an average blood sugar percentage over two to three months stood at 7.2, also in the diabetes range.

The best thing someone can do when they get diagnosed with diabetes or prediabetes is to lose weight, he said. Its the essential key to ridding yourself of diabetes.

[RELATED: Type 1 diabetic from WNY touts little-used inhalable insulin]

Fink had long been interested in the training regimens of top athletes, even though he didnt always follow them himself, so he started from a place he understood: He needed to burn off more calories than he consumed.

Research shows that losing 15 percent of your body weight can lower the risk of Type 2 diabetes by more than 50 percent, according to the American Diabetes Association.

That kind of weight loss needed to start with a new mental approach, Fink reasoned. He started to make better, more educated health and fitness choices going forward every day and not get too discouraged if he slipped up occasionally.

The problem most people have is they want instant gratification, he said. You dont get out of shape overnight. You dont get in shape overnight. Its a process.

Nutrition is key

A Mediterranean diet including plenty of chicken and fish has been part of Richard Fink's nutrition plan. (Robert Kirkham/Buffalo News)

Diet and exercise has to be part of any diabetic regime, no matter what, said Dr. Howard Lippes, a Williamsville endocrinologist.

Fink was determined to add more exercise to his weekly regimen. For him, the remnants of his past made this the easier part. The more important thing to remember is that you cannot out-train a bad diet, he said.

He pretty much knew how to eat right, but the new numbers in his life underlined that he didnt make the best choices often enough. He turned decidedly to a Mediterranean diet. He gave up cereal, white breads and other processed foods made with simple carbohydrates and added sugars. Simple carbs as opposed to their more complex kin, found mostly in vegetables raise blood sugar levels, which promote body inflammation that fuels many chronic diseases, including diabetes, the seventh leading cause of death in the U.S.

Fink fed his better habits with information gleaned from books, magazines and (shameful plug intended) WNY Refresh. He tends to eat eggs for breakfast, a light, chicken-based meal for lunch and dinners rich in chicken, fish, fruits and vegetables. He drinks plenty of water. He has never smoked anything and doesnt drink alcohol, which in excess also promotes disease.

Do I still love wings? Absolutely, he said. Do I still have them once in a while? Sure, but I have changed to a lot of healthy eating. You need to have chicken and fish and salads, and be careful on dressings and toppings. Youve got to read labels, too. I never thought I needed to. The more informed you can become, the better.

Exercise counts

Each member who takes group classes at Orangetheory wears a heart rate monitor to let them know when they approach their maximum heart rate. (Robert Kirkham/Buffalo News)

There are plenty of days I dont want to work out, Fink said, but those are the days that are most important. You have to force yourself to do what you need to do to burn calories, and drive by places where you shouldnt be eating.

[RELATED STORY: Falls Memorial studies new wound treatment]

Fink turned to Orangetheory in Amherst to burn calories. He takes a late afternoon class five to six days a week in which workouts vary, keeping things interesting and targeting different muscle groups. Trainers help guide his fitness and exercise form during hourlong workouts split between challenging treadmill work and circuit training that includes rowing machines, free weights and TRX resistance bands. The workouts focus on splat points one point for every minute in the Orange zone, 84 to 90 percent of your maximum heart rate. You want you to get 12 to 20 points per session to develop an afterburn that keeps you shedding calories for a day or so after your workout.

When I go for my workout, I burn 800, 900 calories, Fink said, so technically, after my workout, I havent eaten because Ive burned off breakfast and lunch.

Your heart is a muscle that Fink compares to a Lamborghini. If you walk every day, thats good, but its like driving that car at 25 miles an hour, he said. Youve got to open that up, raise that heart rate every once in a while, to make sure youre working it.

Its important to check with your doctor before starting an exercise routine.

A new way of life

Fink has learned since last spring that hard, consistent work can pay off. Being healthy is a second job, he said.

He has lost 30 pounds since last year and his A1C level is down to 5.4 below the prediabetic and diabetic range. He is taking a quarter the dose of his original diabetes prescription and looks to soon get off it completely. He aims to stay this way.

You cant say, I got rid of it, so I can eat doughnuts again. You dont want to do that, he said. You can blow a whole workout with foods like that. You have to combine exercise with diet. People say they cant lose weight. Dont say you cant. Say youre not going to make the effort. If youre not making the effort, who are you cheating?

The ABCs of diabetes

Type 1 diabetes:Normally diagnosed in children and young adults. The body does not produce insulin, a hormone needed to convert sugar, starches and other food into energy the bodys cells need for daily life. Only 5 percent of people with diabetes have this form of the disease, which is treated with insulin therapy.

Type2diabetes:Almost 30 million Americans have Type 1 or 2 diabetes; Type 2 is by far the most common form. The body does not produce enough insulin, or the cells ignore the insulin, and glucose builds up in the bloodstream instead.

It is more common as a percentage among African-Americans, Latinos, Native Americans and Asian Americans. Roughly one in four Americans age 65 and older has diabetes.

More than 80 percent of those with Type 2 diabetes are overweight.

Complications, which can vary widely and by degree, include glaucoma, cataracts and other eye problems; numbness in the feet; skin infections and skin disorders; hearing loss; depression; and high blood pressure, which raises your risk for heart attack, stroke and kidney disease.

High blood sugar can overwork the kidneys, causing them to stop working properly. When diagnosed early, kidney disease can be slowed with treatment; when diagnosed later, kidney failure usually results.

Prediabetes:An estimated 86 million Americans have prediabetes. Before people develop Type 2 diabetes, they almost always have prediabetes, or blood glucose levels that are higher than normal but not yet high enough to be diagnosed as diabetes.

Recent research has shown that some long-term damage to the body, especially the heart and circulatory system, may already be occurring during prediabetes.

Key tests

A1C: Measures the average blood sugar (glucose) level percentage over 2-3 months.

Results of A1C:

Normal:less than 5.7 percent

Prediabetes:5.7 to 6.4 percent

Diabetes:6.5 percent or higher

Fasting Plasma Glucose: Levels of milligrams per deciliter of blood glucose after fasting at least 8 hours.

Results of FPG:

Normal:less than 100 mg/dl

Prediabetes:100-125 mg/dl

Diabetes:126 mg/dl or higher

Oral Glucose Tolerance Test: Levels of milligrams per deciliter before and 2 hours after a sweet drink; most often used to test for diabetes during pregnancy.

Results of OCTT:

Normal:less than 140 mg/dl

Prediabetes:140-129 mg/dl

Diabetes:200 mg/dl or higher

Prevention and treatment

Exercise and a healthy diet are key to preventing prediabetes and diabetes, as well as better managing them. (Robert Kirkham/Buffalo News)

Regular exercise and a healthy diet void of processed foods can help.

Smoking, high blood pressure, abnormal blood cholesterol levels, being overweight and being sedentary can worsen diabetes.

Medications and dialysis are treatments that may be required.

Sources: American Diabetes Association (diabetes.org), Seneca Nation of Indians Diabetes Foundation

Resourcesfrom the Buffalo & Erie County Public Libraries

What to Expect When You Have Diabetes: 170 tips for living well with diabetes, American Diabetes Association

Whole Cooking & Nutrition: An everyday superfoods approach to planning, cooking, and eating with diabetes, Katie Cavuto

Your Type 2 Diabetes Action Plan: Tips, techniques, and practical advice for living well with diabetes, American Diabetes Association

The Diabetes Reset: Avoid it, control it, even reverse it a doctors scientific program, George King

Diabetes Without Drugs: The 5-step program to control blood sugar naturally and prevent diabetes complications, Suzy Cohen

For more information, visit buffalolib.org.

email: refresh@buffnews.com

Twitter: @BNrefresh, @ScottBScanlon

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Breastfeeding Helps to Prevent Type 1 Diabetes – Diabetes In Control

May 20th, 2017 4:47 am

Youths who received any breastfeeding for at least 12 months or full breastfeeding for at least six months had lower odds of developing type 1 diabetes.

Data was evaluated from two population-based cohorts on 155,392 children followed from birth (1996-2009) to 2014 (Danish National Birth Cohort) or 2015 (Norwegian Mother and Child Cohort Study) to determine the relationship between the duration of full or any breastfeeding and the risk for type 1 diabetes in children. Infant dietary practices were reported by parents when children were ages 6 and 18 months. The outcome was clinical type 1 diabetes, ascertained from nationwide childhood diabetes registries. Hazard ratios were estimated using Cox regression.

Overall, 504 participants developed type 1 diabetes for an incidence of 30.5 per 100,000 person-years in the Norwegian Mother and Child Cohort and 23.5 per 100,000 person-years in the Danish National Birth Cohort.

Children who were never breastfed had a twofold increased risk of type 1 diabetes compared with those who were breastfed (hazard ratio 2.29 [95% CI 1.144.61] for no breastfeeding vs. any breastfeeding for 12 months). Among those who were breastfed, however, the incidence of type 1 diabetes was independent of duration of both full breastfeeding (hazard ratio per month 0.99 [95% CI 0.971.01]) and any breastfeeding (0.97 [0.921.03]).

Breastfeeding was never initiated in 0.8% of the Norwegian cohort and 2.4% of the Danish cohort; full breastfeeding for at least 6 months was reported in 13.8% of the Norwegian cohort and 6.3% of the Danish cohort; any breastfeeding for at least 12 months was reported in 38.5% of the Norwegian cohort and 20.2% of the Danish cohort.

The risk for developing type 1 diabetes was higher in children who were never breastfed compared with any breastfeeding for at least 12 months (HR = 2.29; 95% CI, 1.14-4.61) and compared with full breastfeeding for at least 6 months (HR = 2.31; 95% CI, 1.11-4.8).

The results from two of the worlds largest birth cohorts provide suggestive evidence for the hypothesis that initiating breastfeeding may reduce the risk of type 1 diabetes, the researchers wrote. However, among those who were breastfed, the study provides strong evidence against a clinically important association with prolonging full or any breastfeeding and risk of type 1 diabetes.

In another but similar study, Nonindigenous Canadian mothers who initiated breastfeeding in the hospital reduced their risk for diabetes by 23%, whereas their offspring experienced an 18% risk reduction for developing the disease, according to study findings presented at the World Diabetes Congress.

In this population-based analysis of more than 330,000 live births during a 24-year period, researchers also found that women saw a 14% risk reduction for diabetes when they initiated breastfeeding.

The message from these studies is that, every mother should try to initiate breastfeeding if she can, no matter how long the duration, to receive beneficial effects including reducing the risk for diabetes.

For this study, they analyzed hospital records from 334,553 deliveries (60,088 First Nation births) taking place in Manitoba between 1987 and 2011. Within the cohort, 262,124 women initiated breastfeeding in the hospital (mean age, 28 years; 13% First Nations; 2.9% with gestational diabetes), and 72,429 did not initiate breastfeeding (mean age, 26 years; 36% First Nations; 4.2% with gestational diabetes), according to hospital records that note breastfeeding initiation at discharge. Researchers also determined diabetes status through hospital records.

Breastfeeding initiation was associated with significantly lower incidence of diabetes in mothers and offspring without a history of gestational diabetes.

Researchers found that First Nations status did not significantly affect the association between breastfeeding and incident diabetes for offspring and, therefore, pooled analyses, finding that children of mothers who initiated breastfeeding had an 18% reduced risk for diabetes (adjusted HR = 0.83; 95% CI, 0.69-0.99).

The protective effects of breastfeeding observed in mothers and children were independent of First Nations status, gestational diabetes, gestational hypertension, maternal age, birth weight, and socioeconomic factors, according to researchers.

Practice Pearls:

Diabetes Care 2017 May; dc170016. https://doi.org/10.2337/dc17-0016

Martens PJ, et al. Abstract #0511. Presented at: World Diabetes Congress; Nov. 30-Dec. 4, 2015

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Propanc Biopharma Highlights PRP’s Potential to Reprogram Cancer Stem Cells (CSCs) – Marketwired (press release)

May 20th, 2017 4:45 am

MELBOURNE, AUSTRALIA--(Marketwired - May 19, 2017) - Propanc Biopharma Inc. (OTCQB: PPCH) ("Propanc Biopharma" or "the Company"), a clinical stage biopharmaceutical company focusing on development of new and proprietary treatments for cancer patients suffering from solid tumors such as pancreatic, ovarian and colorectal cancers, today announced that fresh new insights have emerged into how cancer stem cells (CSCs) are able to resist standard treatments, become more aggressive and spread rapidly. Published in Oncogene, by researchers from the Bellvitge Biomedical Research Institute south of Barcelona, Spain, the findings have significant implications for Propanc Biopharma's lead product PRP, which reprograms CSCs so that they are no longer malignant and a threat to the patient. PRP is a solution for once daily intravenous administration of a combination of two pancreatic proenzymes trypsinogen and chymotrypsinogen.

One of the authors from the study, Dr Miguel ngel Pujana, describes why tumors adapt to and resist certain therapies, like mTOR inhibitors, a treatment used in advanced stages of breast cancer. He links mTOR inhibition with increased expression of certain genes, like EVI1, which contributes to epithelial to mesenchymal transition (EMT), a key process by which cancer cells become stem cell-like, motile and invasive, seeding new tumors. Dr Miguel concludes, "Tumor cells are able to adapt to treatment through a phenotype (character) shift that makes them more aggressive and sustains their metastatic potential." Data from hundreds of cell lines expand on the concept that CSCs are frequently the source of therapy resistance and metastasis, the main cause of patient death from cancer.

"When administering PRP to a patient, we are essentially reprogramming CSC gene expression, pushing these cells back to a normal, less malignant state, so they die naturally," said Dr Kenyon, Propanc's Chief Scientific Officer. "Reversing the EMT process is a key feature of PRP and is fast becoming a credible solution to controlling CSCs, which are responsible for cancer spreading, or metastasis, the main cause of patient death from cancer."

"The latest scientific discoveries regarding CSC reprograming shows we are on the right track, which we believe is not reflected in our current market capitalization," said James Nathanielsz Propanc's Chief Executive Officer. "Nevertheless, we are advancing towards First-In-Human studies and remain excited about developing PRP as a new therapeutic approach for cancer sufferers. We remain focused on delivering long term value to our loyal shareholders."

The rationale for developing PRP is based on a set of in-vitro studies on CSCs, as well as xenograft and syngeneic mouse models of ovarian and pancreatic cancers, respectively. In summary, these data indicate that the dramatic reduction of cellular markers associated with the process of EMT as a consequence of PRP treatment, could not only reverse the EMT process with the implication to stop tumor progression and metastasis, but also seem to suppress the development of CSCs. Consequently, these results are strong indicators of the therapeutic potential of PRP that could be categorized as an anti-CSC therapeutic drug.

Currently progressing towards First-In-Human studies, PRP aims to prevent tumor recurrence and metastasis from solid tumors. Eighty percent of all cancers are solid tumors and metastasis is the main cause of patient death from cancer. According to the World Health Organization, 8.2 million people died from cancer in 2012. Consequently, a report by IMS Health states innovative therapies are driving the global oncology market to meet demand, which is expected to reach $150 Billion by 2020. The Company's initial target patient populations are pancreatic, ovarian and colorectal cancers, representing a combined market segment of $14 Billion predicted in 2020, by GBI Research.

To view Propanc Biopharma's "Mechanism of Action" video on anti-cancer product candidate, PRP, please click on the following link: http://www.propanc.com/news-media/video

To be added to Propanc Biopharma's email distribution list, please click on the following link: http://ir.propanc.com/email-alerts and submit the online request form.

About Propanc Biopharma:Propanc Biopharma is a clinical stage biopharmaceutical company developing new cancer treatments initially for patients suffering from pancreatic, ovarian and colorectal cancers. We have developed a formulation of anti-cancer compounds, which exert a number of effects designed to control or prevent tumors from recurring and spreading throughout the body. Our products involve or employ pancreatic proenzymes, which are inactive precursors of enzymes. In the near term, we intend to target patients with limited remaining therapeutic options for the treatment of solid tumors. In future, we intend to develop our lead product to treat (i) early stage cancer and (ii) pre-cancerous diseases and (iii) as a preventative measure for patients at risk of developing cancer based on genetic screening. For more information, visit: http://www.propanc.com.

Forward-Looking Statements:All statements other than statements of historical fact contained herein are "forward-looking statements" for purposes of federal and state securities laws. Forward-looking statements may include the words "may," "will," "estimate," "intend," "continue," "believe," "expect," "plan" or "anticipate" and other similar words. Although we believe that the expectations reflected in our forward-looking statements are reasonable, actual results could differ materially from those projected or assumed. Our future financial condition and results of operations, as well as any forward-looking statements, are subject to change and to inherent risks and uncertainties including those regarding our earnings, revenues and financial condition, our ability to implement our plans, strategies and objectives for future operations, our ability to execute on proposed new products, services or development thereof, our ability to establish and maintain the proprietary nature of our technology through the patent process, our ability to license from others patents and patent applications, if necessary, to develop certain products, our ability to implement our long range business plan for various applications of our technology, our ability to enter into agreements with any necessary manufacturing, marketing and/or distribution partners for purposes of commercialization, the results of our clinical research and development, competition in the industry in which we operate, overall market conditions, and any statements or assumptions underlying any of the foregoing. Other risks, uncertainties and factors that could cause actual results to differ materially from those projected may be described from time to time in reports we file with the Securities and Exchange Commission, including our reports on Forms 10-K, 10-Q and 8-K. We do not intend, and undertake no obligation, to update any forward-looking statement contained herein, except as required by law.

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An Experimental Gene Therapy Uses Viruses to Stop Age-Related … – Futurism

May 20th, 2017 4:44 am

In Brief Researchers from Johns Hopkins Medicine in Maryland have discovered a rather unusual way to treat a severe form of age-related blindness. They found a virus inserted into the retina can be used to halt or even reverse the disease. A Unique Treatment

They say you dont fight fire with fire. However, researchers from Johns Hopkins Medicine in Maryland have found that sometimes a virus may be the best weapon against a disease.Their studyhas been publishedin The Lancet

The researchers werelooking for ways to treat a particular type ofage-related macular degeneration (AMD)known as a wet AMD. Its a rare and more severe form of the disease,affecting just 10 percent of all AMD patients, and it causes new blood vessels to grow under the retina, which then leak blood and fluid into the eye, leading to vision problems.

The researchers knewthey could halt and even reverse the condition by suppressing an overactive protein called vascular endothelial growth factor (VEGF). Other researchers had been able to do it with monthly eye injections, but this team was hoping to do it with just one injection.

The best way they found to do this was by using a common cold-like virus called AAV2 as a carrier of gene that activates the production of a differentprotein,sFLT01, tocounter VEGF.

In a preliminary trial involving 19 men and women 50 years old and above, the researchers injected the patients with a form of AAV2that was genetically engineered to penetrate retinal cells and deposit the gene. After the virus deposited the gene, the cells began secreting sFLT01 which bound to VEGF and prevented it from stimulating leakage and growth of abnormal blood vessels, explained a Johns Hopkins press release.

The clinical trial showed promising results, with the condition of four of the patients improving dramatically after just one viral injection. Two others saw some reduction in the fluid build up, and the treatment didnt produce any side effects in any patients. Even at the highest dose, the treatment was quite safe. We found there were almost no adverse reactions in our patients, said researcher Peter Campochiaro.

Of the patients that didnt respond, the researchers discovered that five naturally produced antibodies that would attack the AAV2 virus, rendering it unable to complete its gene depositing mission. They think these antibodies could be prevalent throughout the population, making it difficult to determine how effecting the treatment would actually be.

Nevertheless, this research is a step in the right direction, especially with AMD expected to affect almost 5.44 million people in the U.S. by 2050. This preliminary study is a small but promising step towards a new approach that will not only reduce doctor visits and the anxiety and discomfort associated with repeated injections in the eye, but may improve long-term outcomes, Campochiaro said.

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Harwood Feffer LLP Announces Investigation of Puma Biotechnology, Inc. – PR Newswire (press release)

May 20th, 2017 4:44 am

On May 4, 2017, Puma announced the resignation of its Senior Vice President, Regulatory Affairs, effective as of May 15, 2017, less than two weeks before the FDA's scheduled review of neratinib. On May 5, 2017, Fox Business published an article reporting that a large number of patients taking neratinib suffered from severe side effects, posing a safety risk for the drug.

Our investigation concerns whether the Company board of directors has breached its fiduciary duties to shareholders, grossly mismanaged the Company, and/or committed abuses of control in connection with the foregoing.

If you own Puma shares and wish to discuss this matter with us, or have any questions concerning your rights and interests with regard to this matter, please contact:

Robert I. Harwood, Esq. Benjamin I. Sachs-Michaels, Esq. Harwood Feffer LLP 488 Madison Avenue New York, New York 10022 Phone Numbers: (877) 935-7400 (212)935-7400 Email: bsachsmichaels@hfesq.com Website: http://www.hfesq.com Follow us on Twitter: @HarwoodFeffer

Harwood Feffer has been representing individual and institutional investors for many years, serving as lead counsel in numerous cases in federal and state courts. Please visit the Harwood Feffer LLP website (http://www.hfesq.com) for more information about the firm.

Attorney Advertising. The law firm responsible for this advertisement is Harwood Feffer LLP (www.hfesq.com). Prior results do not guarantee or predict a similar outcome with respect to any future matter.

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/harwood-feffer-llp-announces-investigation-of-puma-biotechnology-inc-300460923.html

SOURCE Harwood Feffer LLP

http://www.hfesq.com

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Harbour Investment Management LLC Invests $4.559 Million in iShares NASDAQ Biotechnology Index (IBB) – The Cerbat Gem

May 20th, 2017 4:44 am

Investopedia
Harbour Investment Management LLC Invests $4.559 Million in iShares NASDAQ Biotechnology Index (IBB)
The Cerbat Gem
iShares NASDAQ Biotechnology Index logo Harbour Investment Management LLC bought a new position in iShares NASDAQ Biotechnology Index (NASDAQ:IBB) during the first quarter, according to its most recent filing with the Securities and Exchange ...
Lucas Capital Management Has $2.254 Million Stake in iShares NASDAQ Biotechnology Index (IBB)Sports Perspectives
The 745 Shares in iShares NASDAQ Biotechnology Index (IBB) Acquired by Schnieders Capital Management LLCBangaloreWeekly
Davidson & Garrard Inc. Lowers Stake in iShares NASDAQ Biotechnology Index (IBB)Markets Daily
BBNS -Transcript Daily -Chaffey Breeze
all 31 news articles »

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