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Debunking common myths about arthritis – WHAG

May 12th, 2017 2:41 am

MONTGOMERY COUNTY, Md. - Things as simple as standing, walking and moving your hands can inflict serious pain on people suffering from arthritis.

"We have treatments for inflammatory arthritis that actually modify the disease, [with] what we call disease-modifying-agents, that actually change the course of the disease and can prevent joint destruction, said Dr. Siegel.

Since the completion of the human genome, combating arthritis can involve a more articulated strategy, where researchers can target specific molecules.

"Now that we know who the players are, we can then try to figure out exactly what they do in different diseases, said Dr. John O'Shea, Scientific Director at NIAMS, NIH. Then you can take a strategy, saying, I think this guy is a bad actor, and so we can make a drug that targets that guy."

Not only can you make a drug that targets specific molecules, but you can repurpose one for it, which is what the NIH is currently trying to do with tofacitinib, a drug initially approved for rheumatoid arthritis and now being tested to treat lupus.

"As serious as these problems are, we should be optimistic that if we keep investing in trying to cure and treat these diseases, that we will succeed, said Dr. OShea.

The CDC projects that by 2025, 67 million people in the U.S. will have arthritis.

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Local high school football player takes on rheumatoid arthritis – Clarksville Now

May 12th, 2017 2:41 am

CLARKSVILLE, Tenn. (ESPN CLARKSVILLE) Juvenile rheumatoid arthritis is a disease that affects over 300,000 children across the country, according to the America College of Rheumatology. Juvenile Rheumatoid Arthritis (JRA) is caused by the bodys immune system attacking its own healthy tissue and can be linked to genetics. Persistent joint pain, swollen joints, limping or preference of one leg or arm are just a few of the everyday battles these children take on every day.

Mitchell Briningstool has taken on the disease for most of his young life. He was diagnosed with JRA at the age of two. Mitchell, a junior at Clarksville Academy, does not let his current condition dictate his daily routines. Hes currently a member of the varsity football team, and has played high school baseball and basketball since his freshman year.

In addition to being a member of the football team, Mitchell is also the leader and the face of Team Mitch, and hell be leading his team on Sunday, May 21 to Walk to Cure Arthritis at Centennial Park in Nashville. Not only will he be leading his team to raise money and awareness, Mitchell was selected as the Team Champion for this event.

The Briningstool family asks that you consider a financial donation, or taking part in the event and day of fun on May 21. There are also some events here in town leading up to the Walk to Cure Arthritis. On Thursday, May 11, Chic Fil a on Wilma Rudolph Blvd. will host Team Mitch night from 5-8 p.m. where a portion of the the sales will be donated to Team Mitch for everyone who mentions they are there for his event. The money will help fund The Arthritis Foundation for research and education.

There will also be a charity basketball game on May 19 at the Clarksville Academy gym. The evening kicks off at 5 p.m. and will consist of free basketball training, a three point shooting contest, free throw contest, and capped off with Team Mitch taking on Team RTG. Admission is free, but donations will be accepted.

Come out and support Mitchell and The Arthritis Foundation during one of these three events. If you cant make it, you can also make a donation online.

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Psychological well-being among US adults with arthritis and the unmet need for mental health care – Dove Medical Press

May 12th, 2017 2:41 am

Laura E Straub,1,2 Miriam G Cisternas3

1Emory University, Atlanta, GA, 2Immune Tolerance Network, San Francisco, CA, 3MGC Data Services, Carlsbad, CA, USA

Purpose: Mental health conditions can increase the risk of disability among adults with arthritis. The objective of this analysis was to compare the prevalence of serious psychological distress (SPD), depression, and anxiety among US adults with arthritis vs. those without; characterize adults with arthritis with and without SPD; and determine correlates of seeing a mental health professional during the year for adults with arthritis and SPD. Materials and methods: Cross-sectional analysis of adults in the 20112013 National Health Interview Survey. Results: Higher proportions of adults with arthritis had SPD (6.8% vs. 2.4%), depression (19.4% vs. 7.3%), and anxiety (29.3% vs. 16.3%) compared to those without. Of the estimated 3.5 million adults with arthritis and SPD, only 39% saw a mental health professional during the year. Adjusted analyses identified the following statistically significant relationships: those who were older (4564 and 65 [vs.1844], prevalence ratio [PR]=0.8 and 0.4, respectively), less educated (PR=0.5 and 0.7 for high school or less vs. college degree, respectively), and without health insurance coverage (vs. any private, PR=0.7), were less likely to see a mental health professional, whereas the disabled or unemployed (vs. employed, PR=1.6 and 1.5, respectively), and those unable to afford mental health care throughout the year (PR=1.3) were more likely. Conclusion: The high prevalence of SPD, anxiety, and depression in adults with arthritis suggests the need for increased mental health screening, with subsequent referral to mental health professionals or other treatment programs, in that population.

Keywords: serious psychological distress, anxiety, depression, access to mental health care, rheumatoid arthritis

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Living With Rheumatoid Arthritis: Miss Washington’s Journey to Miss USA – KCTS 9

May 12th, 2017 2:41 am
Living With Rheumatoid Arthritis: Miss Washington's Journey to Miss USA
KCTS 9
Doctors eventually diagnosed her with Rheumatoid Arthritis (RA). She was told that she may never walk again. Although Alex appears to be the picture of health, dealing with the chronic pain of RA is a constant struggle. The term 'invisible illness ...

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International Stem Cell Corporation to Present Results of Neural Stem Cell Transplantation for Parkinson’s Disease … – GlobeNewswire (press release)

May 10th, 2017 9:44 pm

May 04, 2017 08:30 ET | Source: International Stem Cell Corporation

CARLSBAD, Calif., May 04, 2017 (GLOBE NEWSWIRE) -- International Stem Cell Corporation (OTCQB:ISCO), a California-based clinical stage biotechnology company developing stem cell-based therapies and biomedical products, today announced that its Chief Scientific Officer, Russell Kern, PhD, will deliver an oral presentation on the Company's Parkinson's disease clinical trial at the American Society of Gene & Cell Therapy 20th Annual Meeting at the Marriott Wardman Park in Washington, DC.

Session Information

Session Date/Time:Thursday May 11, 2017 3:45 PM - 5:15 PM Session title:Clinical Trials for Neurologic and Neurosensory Disorders Room:Marriott Salon 1 Presentation Time:5:00pm - 5:15pm Presentation title: Update on the First-in-Human Clinical Study Evaluating Neural Stem Cells in Patients with Parkinsons Disease

Session Date/Time:Thursday May 11, 2017 3:45 PM - 5:15 PM Session title:Pharmacology, Toxicology and Assay Development Room:Maryland ABC Presentation Time:3:45pm - 4:00pm Presentation title: Pharmacology and Toxicology Studies Conducted for the First-in-Human Clinical Study of Neural Stem Cells in Parkinsons Disease

About the clinical study

The Phase I clinical study is a dose escalation safety and preliminary efficacy study of ISC-hpNSC, intracranially transplanted into patients with moderate to severe Parkinson's disease. The open-label, single center, uncontrolled clinical trial will evaluate three different dose regimens of 30,000,000 to 70,000,000 neural cells. A total of 12 participants with moderate to severe Parkinson's disease will be treated. Following transplantation, the patients will be monitored for 12 months at specified intervals, to evaluate the safety and biologic activity of ISC-hpNSC. PET scan will be performed at baseline, as part of the screening assessment, and at 6 and 12 months after surgical intervention. Clinical responses compared to baseline after the administration of ISC-hpNSC will be evaluated using various neurological assessments such as Unified Parkinson Disease Rating Scale (UPDRS), Hoehn and Yahr and other rating scales.

About Parkinson's disease

Parkinson's disease (PD) is a degenerative disorder of the central nervous system mainly affecting the motor system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain. Early in the course of the disease, the most obvious symptoms are movement-related; these symptoms include shaking, rigidity, slowness of movement and difficulty with walking and gait. Later, thinking and behavioral problems may arise, with dementia commonly occurring in the advanced stages of the disease, and depression is the most common psychiatric symptom. Parkinson's disease is more common in older people, with most cases occurring after the age of 50.

Currently, medications typically used in the treatment of Parkinson's, L-DOPA and dopamine agonists, improve the early symptoms of the disease. As the disease progresses and dopaminergic neurons continue to be lost, the drugs eventually become ineffective while at the same time frequently producing a complication marked by involuntary writhing movements. In 2013 PD resulted in about 103,000 deaths globally, up from 44,000 deaths in 1990.

About ISC-hpNSC

International Stem Cell Corporation's proprietary ISC-hpNSC consists of a highly pure population of neural stem cells derived from human parthenogenetic stem cells. ISC-hpNSC is a suspension of clinical grade cells manufactured under cGMP conditions that have undergone stringent quality control measures and are clear of any microbial and viral contaminants. Preclinical studies in rodents and non-human primates have shown improvement in Parkinson's disease symptoms and increase in brain dopamine levels following the intracranial administration of ISC-hpNSC. ISC-hpNSC provides neurotrophic support and cell replacement to the dying dopaminergic neurons of the recipient PD brain. Additionally, ISC-hpNSC is safe, well tolerated and does not cause adverse events such as dyskinesia, systemic toxicity or tumors in preclinical models. International Stem Cell Corporation believes that ISC-hpNSC may have broad therapeutic applications for many neurological diseases affecting the brain, the spinal cord and the eye.

About International Stem Cell Corporation International Stem Cell Corporation (ISCO) is focused on the therapeutic applications of human parthenogenetic stem cells (hpSCs) and the development and commercialization of cell-based research and cosmetic products. ISCO's core technology, parthenogenesis, results in the creation of pluripotent human stem cells from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenetic, homozygous stem cell line that can be a source of therapeutic cells for hundreds of millions of individuals of differing genders, ages and racial background with minimal immune rejection after transplantation. hpSCs offer the potential to create the first true stem cell bank, UniStemCell. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology (www.lifelinecelltech.com), and stem cell-based skin care products through its subsidiary Lifeline Skin Care (www.lifelineskincare.com). More information is available atwww.internationalstemcell.com.

To subscribe to receive ongoing corporate communications, please click on the following link:http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0 To like our Facebook page or follow us on Twitter for company updates and industry related news, visit:www.facebook.com/InternationalStemCellCorporationandwww.twitter.com/intlstemcell

Safe harbor statement Statements pertaining to anticipated developments, expected results and timing of clinical studies, potential applications of ISC-hpNSC to other diseases, progress of research and development initiatives, and other opportunities for the company and its subsidiaries, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products (including clinical trial results that differ from expectations based on earlier studies), regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update forward-looking statements.

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New Durham detention director aims to stem suicides – WNCN

May 10th, 2017 9:44 pm

WNCN
New Durham detention director aims to stem suicides
WNCN
In March, Uniece Fennell, 17, died in her cell. The Sheriff's Office says she was found hanging from a bed sheet attached to a window. In the cells, if you would, there was an opportunity to use certain parts of that cell to assist in suicides, said ...

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Why Don’t We Have the Technology to Cure Cancer Yet? – Huffington post (press release) (blog)

May 10th, 2017 9:44 pm

Chances are, you or a loved one will develop cancer at some point during your lives. Worldwide, cancer is one of the leading causes of death, with one in six deaths attributable to the disease. There were over 8.8 million cancer-related deaths in 2015 alone, and the number of new cancer cases each year tallies in the tens of millions.

We have state-of-the-art facilities to treat cancer, such as the Rush University Cancer Center in Chicago, which specializes in oncology research, and the Mayo Clinic in Rochester, Minnesota, which ranks as one of the best treatment centers in the United States. Were also funneling millions of dollars into cancer research, and have known about the disease in some capacity since the days of Hippocrates, stretching back 2300 years.

In that time, weve identified and cured countless diseases with much lower risks and mortality rates, so why havent we been able to eradicate cancer yet?

There are several reasons why cancer remains such an elusive disease:

1. There are many types of cancer.

First off, cancer isnt a disease; its a collective term for hundreds of diseases. Lung cancer, prostate cancer, breast cancer, and brain cancer, for example, all have different risk factors, pathologies, and symptoms, and must be treated very differently. Even within one branch of cancer, there can be dozens to hundreds of different variants. For example, cancer cells are categorized, and certain types (such as cancer stem cells) can transform into further different types. This makes it nearly impossible to comprehensively study cancer as a whole. Instead, we must divide our focus to each individual iteration of the disease, and attempt to solve those problems one at a time.

2. Carcinogenesis is ridiculously complex.

Carcinogenesis, the mutation of otherwise healthy cells into cancer cells, is an enormously complicated process. Theres no simple trigger point that converts a healthy cell into a cancer cell; even the earliest estimations of the process reduced it to no fewer than six individual steps. Today, thanks to advanced computer models, we know there are hundreds to thousands of different genes collectively responsible for that conversion process, making it extraordinarily hard to understand, prevent, and/or reverse.

3. Cancer is produced from the bodys own cells.

Its also important to remember that cancer comes from the bodys own cells. Cancerous cells are still part of youtherefore, they are exceedingly hard to target without also targeting other parts of you. Cancer treatments often focus on trying to destroy cancer cells, but in the process, this approach can do more harm than good. The bodys immune system is unable to identify and fight cancer on its own (in many cases), though recent progress has been made in attempting to use the immune system against cancer.

4. Theres no virus or bacteria to target.

Cures and treatments for conventional diseases focus on targeting and exploiting a structural weakness in the prime cause for the disease. For example, with bacterial infections, most antibiotics attempt to puncture the cells lining to kill the bacterial cell. Since cancer cells arent easy to destroy, and dont share qualities with killable bacteria or viruses, its hard to come up with a treatment that eradicates the disease entirely.

5. Individuals respond differently to different treatments.

There are dozens of different cancer treatments already, including radiation therapy, chemotherapy, surgeries, immunotherapy, and stem cell therapy. However, these treatments may have different levels of effectiveness and different levels of tolerance, depending on the individual responding to them. When researchers discover a new potential treatment for a specific type of cancer, it may only be applicable to a portion of cancer sufferers.

Because these factors cant be addressed with simple advancements in technology, and because we cant change the nature of cancer, its impossible to ever develop a once-size-fits-all cure for cancerat least not in the conventional sense.

Is this reason to despair? Not necessarily. Instead of pooling our efforts to curing cancer, were focusing on treating cancer. Were developing technology that can mitigate the pain and weakness associated with the disease, were inventing new treatment options that can potentially help more individuals, and were finding new ways to eradicate certain manifestations of the disease.

Cancer mortality rates are falling and life expectancies are risingand thats the best we can hope for.

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Biotechnology dept to set up tissue culture lab – Millennium Post

May 10th, 2017 9:43 pm

The state Biotechnology department has decided to set up a state-of-the-art plant tissue culture laboratory at the Kolkata Biotech Park to enhance production and quality of plants and vegetables.

There will be scientists and research fellows who will carry out various kinds of research on plants and bio-fertilizers and how they can be used to increase the production of vegetables in the state. Various medicinal plants will be conserved in the Biotech Park for research purposes. It has been learnt that the department is in the process of formulating the Biotech Policy for Bengal.

The state government has already taken the initiative to upgrade the infrastructure of Kolkata Biotech Park, apart from setting up new Biotechnology hubs in Burdwan and Kalimpong. The department has been focusing on the modernisation and expansion of the Common Instrument Facility Centre in the Biotech Park in the city. The department of Biotechnology will obtain all the necessary approvals and clearances to secure funding for the augmentation of the 'Bioincubator Facility' in Kolkata.

The department has a plan to conduct research on tissue culture to increase the yield and quality of various products but also to provide germ-free food to the common people. The Biotechnology department will tie up with other departments like Agriculture, Fisheries and Food Processing to strengthen organisational collaboration.

Better co-ordination with other departments will help the Biotechnology department to successfully implement the schemes. The department will help the Agriculture department to improve the quality of various fertilizers. It is also working to increase the production of fishes for the Fisheries department.

Tissue culture will be of immense help in increasing the productivity of land by enhancing crop quality, developing crops resistant to biotic and abiotic stresses, developing bio-fertilizers and bio-pesticides.

Bengal is rich in the biodiversity of crops, vegetables, fruits, flowers and other plant resources. The main objectives of the department are to provide better facilities to the common people and to improve the quality of life. It will also promote the overall development of both traditional and modern biotechnology in the state including various livelihood development programmes. It will also strengthen biotechnology-based aspects that will help in the development of the state economy from the grass-root level.

The Biotechnology department is applying specialised knowledge, skills and management to develop a viable and vibrant biotechnology-based industry in the state. It stresses on equitable and inclusive development through scientific means.

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Noisy Knees? Arthritis May Be in Your Future – New York Times

May 10th, 2017 9:43 pm

New York Times
Noisy Knees? Arthritis May Be in Your Future
New York Times
If your knees creak and pop, the noises could be an indicator of early arthritis, even if the joint does not hurt, according to one of the first long-term studies of the association between noisy knees and joint disease. But not every creaky knee is ...

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Arthritis pain: Exercise ‘could be JUST as effective as surgery at managing knee agony’ – Express.co.uk

May 10th, 2017 9:43 pm

GETTY

A study claims arthroscopies should not be performed on those suffering painful degenerative knee disease because it rarely works.

In fact, a collaboration of international experts said the keyhole procedure to relieve pain and improve movement should be avoided in almost all patients.

Their recommendation is based on evidence that it does not result in lasting improvement in pain or function.

The panel said: Knee arthroscopy has been oversold as a cure-all for knee pain.

We make a strong recommendation against the use of arthroscopy in nearly all patients with degenerative knee disease.

"Further research is unlikely to alter this recommendation.

Degenerative knee disease is a chronic condition in which symptoms fluctuate.

Each year around two million people go under the knife but the procedure is no better than traditional exercise or physiotherapy.

Knee arthroscopy has been oversold as a cure-all for knee pain

Research panel

Around a quarter of those aged over 50 years experience pain from degenerative knee disease with weight loss, exercise and anti-infammatory drugs and surgery options to combat the debilitating pain.

Knee replacement is the only definitive therapy, but it is usually reserved for patients with the severest form of the disease.

The review by bone surgeons, physiotherapists, clinicians and patients with experience of degenerative knee disease suggests arthroscopic surgery offers little benefit and is not cost effective.

GETTY

The assessment comes after the panel carried out a detailed analysis of the available evidence.

A linked review of 13 random control trials and 12 observational studies concluded the treatment did not reap important benefits in pain or function.

Researchers found that when compared with conservative management surgery resulted in a very small reduction in pain up to three months following the procedure and very small or no pain reduction up to two years later.

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1 of 12

They also found knee arthroscopy results in a very small improvement in the short term and very small or no improved function up to two years after the operation.

Patient Casey Quinlan said: Knee arthroscopy has been oversold as a cure-all for knee pain.

"Mine was nowhere near what I had been told it would be, function and pain level were only marginally improved.

Degenerative arthritis is a group of conditions where the main problem is damage to the cartilage which covers the ends of the bones.

Painful and debilitating degenerative knee arthritis affects around 4 million people in the UK.

Mark Wilkinson, Professor of Orthopaedics at the University of Sheffield and Arthritis Research UK spokesman, said: Previous studies have shown knee arthroscopy is not recommended for the symptoms of pain and loss of function for people with degenerative knee arthritis.

"People with mechanical symptoms, such as locked knee, are more likely to benefit for this type of surgery. Current guidelines support this.

GETTY

Anyone with pain and loss of function in their knee joints will find benefit from lifestyle modification, exercise, physiotherapy, suitable pain medication, or joint replacement when non-surgical treatment becomes no longer effective.

Publishing their findings in the BMJ the experts said: We make a strong recommendation against the use of arthroscopy in nearly all patients with degenerative knee disease, based on linked systematic reviews.

"Further research is unlikely to alter this recommendation.

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Arthritis Foundation set for Nashville walk – The Tennessean

May 10th, 2017 9:43 pm

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Walk to Cure Arthritis(Photo: Submitted)

The Arthritis Foundation is set to host its annual Walk to Cure Arthritis in Nashville.

The walk features a three-mile and one-milenoncompetitive course along with family-friendly activities. Dogs are welcome.

Funds will go to help speed up the cure for arthritis, a common cause of disability.

The walk is1:30 p.m.Sunday, May 21,at the Centennial Park band shell, 2500 West End Ave., in Nashville.

Registration is free and donations are encouraged. Visit walktocurearthritis.org/Nashville.

Reach Alex Hubbard at dhubbard@tennessean.com.

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Retired teacher doesn’t let arthritis slow her down – Northeast Mississippi Daily Journal

May 10th, 2017 9:43 pm

SALTILLO For Martha Webb, cooking is all about using the best and freshest ingredients available.

If you dont use good ingredients, youre not going to end up with something thats fit to eat, said Webb, 59.

Her husband, Raymond, regularly travels to Pontotoc County to buy her butter that folks in the Amish community make, and she grows many of her own vegetables and herbs.

Her side yard in Saltillo is planted with huge beds of rosemary, basil, dill, oregano, sage, Italian parsley and cilantro. Come summer, shell have tomatoes, running beans, squash and bell peppers.

Ive planted new potatoes for the grandkids to dig up and my asparagus is just about gone, she said. We had 60 heads of Romaine lettuce but only three are left now. And I love my herbs. I cant cook without fresh herbs.

The mother of two and grandmother of three learned gardening as a child.

When I was growing up, if we didnt grow it or kill it, we didnt eat it, Webb said. Daddy had a truck patch and my brothers hunted and fished and I hunted and fished, she said. The only thing Mama went to the store for was staples.

Webb, who was raised in Union County but now lives in Saltillo, went to college at Bethel University in Tennessee where she had a double major: piano and drama. She taught music at South Pontotoc and at Plantersville before moving to the Fillmore Center, an alternative school in Tupelo, to teach English.

Fillmore was an interesting job, she said. I loved those kids. The ones you could help made up for the ones you couldnt.

Webb retired early from teaching in 2015 due to rheumatoid arthritis. As long as her hands will allow her, shell continue to play the piano at Wesley United Methodist Church, a job shes held for 23 years.

Because shes busy with church Sunday mornings, she gets her Sunday dinner started early. She plans the menu on Wednesday and starts cooking on Saturday. She might serve Hawaiian ham with peas, greens and a salad, or a beef roast with potatoes and carrots, green beans and slaw.

Sometimes we have chicken, sometimes meatloaf, and sometimes my husband will smoke a pork loin or pork butt, she said. My kids have never known not having Sunday dinner. Even growing up, we had dinner together every night at the table. If you werent dead, then youd better be there.

Webb actually uses the weekends to get most of her meals ready for the week ahead.

I do quality cooking I dont just run in there and make Hamburger Helper, she said. Both my daughters can cook. Whatever is important to you is going to be important to your kids. I have the best children and the best life and I feel guilty every day for what God has given me.

1 box Duncan Hines lemon supreme cake mix

1 small box instant lemon pudding mix

1/2 cup Limoncello liqueur

1/4 cup Limoncello liqueur

4 ounces cream cheese, softened

1/2 to 3/4 cup confectioners sugar

For the cake, preheat the oven to 350 degrees. Combine cake mix, pudding mix, eggs, oil, sour cream and Limoncello in a large bowl and beat for 2 minutes. Pour batter into a greased and floured Bundt pan and bake for 45 to 55 minutes or until cake lightly springs back when touched. Cool for a few minutes in the pan, then invert onto a cake plate. Dust with confectioners sugar or glaze with Limoncello Frosting.

For the frosting, melt butter in a small saucepan over medium heat. Stir in Limoncello. Simmer for 4 to 5 minutes, stirring often. Remove from heat and using a mixer, whip in cream cheese and sugar until the frosting is thick, but still pourable. Drizzle over cooled cake.

1 precooked, smoked shank ham

1 large can sliced pineapple in heavy syrup

3/4 cup light brown sugar

1/4 teaspoon ground cloves

3/4 cup apricot preserves

Preheat oven to 350 degrees. Lightly score ham. Mix the juice from the canned pineapple with the apricot nectar. Stir in brown sugar and cloves. Using an injector for meats, inject the solution liberally into the ham. Place in a roasting pan and cover with foil. Bake for 1 1/2 hours. Uncover the ham and, using toothpicks, place pineapple slices on the fat sides of the ham, with cherries in the center of the slices. Heat any remaining sauce and add preserves. Baste the ham with this sauce every 15 minutes as the ham bakes, uncovered, another 30 minutes.

1 stick butter, room temperature

1 teaspoon vanilla flavoring

1/4 teaspoon almond flavoring

3/4 cup granulated sugar, plus extra for sprinkling

1 cup confectioners sugar

2 1/4 cups self-rising flour

This recipe must be followed exactly and in order for the dough to have the right consistency.

Preheat oven to 300 degrees. Line a cookie sheet with parchment paper.

With a mixer on low speed, whip the butter until fluffy. Add oil, egg and flavorings. Add both sugars and beat until blended. Add flour a little at a time. The dough should be soft. Roll dough into 1-inch balls and place on prepared cookie sheet. Press a smooth-bottomed drinking glass into extra granulated sugar and then press cookie balls to flatten. Bake until cookie edges are golden. Cool slightly then remove to paper towels to completely cool. Makes 3 1/2 to 4 dozen 3-inch cookies.

2 cups coarsely chopped, cooked squash

Cool squash, then mix in egg, onion and flour. Drop by rounded tablespoons into hot vegetable oil and cook until golden brown. Drain on paper towels.

1 pound ground mild Italian sausage

2 pounds Angus ground chuck

1 medium sweet onion, chopped

1 medium green bell pepper, chopped

1 (28-ounce) can tomato sauce

1 (28-ounce) can petite-diced tomatoes

1 (28-ounce) can crushed tomatoes

1/2 cup chopped fresh basil

1/4 cup chopped fresh oregano

1 tablespoon dried Italian seasoning

Brown sausage and ground chuck in olive oil. Drain off any fat. To the pan, add onion, bell pepper and garlic and saute a couple of minutes. Add remaining ingredients and bring sauce to a boil. Reduce heat to low and simmer slowly for at least 1 hour (longer is better). Stir often and add water if sauce becomes too thick. This sauce freezes well.

4 small zucchini (8- to 10-inches)

1 cup chopped red bell pepper

4 cups fresh corn (or 2 packages frozen, thawed)

1 large tomato, seeded and chopped

1 cup grated Parmesan cheese

Slice zucchini lengthwise into quarters, then slice across into 1/2-inch thick slices.

Melt butter in a skillet and add onion and bell pepper. Saute a couple of minutes and stir in corn. Season with salt and pepper and cook for 4 to 5 minutes. Stir in zucchini and cook 2 or 3 minutes, covered. Remove from heat and stir in tomato and sprinkle with cheese. Place under the broiler until the cheese is melted. Serves 8.

1 flute or batard Italian bread

1 cup cherry tomatoes, quartered

1/2 cup chopped fresh basil

1/4 cup chopped fresh oregano

1 to 2 cloves minced garlic

1 teaspoon red wine vinegar

Shredded Italian 5-cheese blend

Preheat oven to 450 degrees.

Slice bread into 3/4-inch-thick slices. Brush with olive oil and place on a greased cookie sheet. Place in oven until lightly crisped.

In a bowl, combine tomatoes, herbs, garlic and vinegar. Top bread slices with tomato mixture. Sprinkle with grated cheese and drizzle with balsamic glaze. Place back in oven until cheese is melted. Makes about 12.

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Retired teacher doesn't let arthritis slow her down - Northeast Mississippi Daily Journal

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Teen suffering from arthritis gets a little help from his friends – C&G Newspapers

May 10th, 2017 9:43 pm

Walk to Cure Arthritis is May 13 at zoo

Posted May 10, 2017

FRASER When Matthew Dantes was 9 years old, he started to experience physical ailments most children his age couldnt comprehend. Today, Matthew, 18, has juvenile rheumatoid arthritis.

The gamut of aches, pains, joint stiffness, rashes, fevers and difficulty walking originally confounded doctors. Matthews mother, Christine Dantes, said her son was misdiagnosed for three years because doctors couldnt connect a 9-year-olds symptoms with a particular disease.

A lot of doctors dont know what this disease looks like on a child, Christine Dantes said. That is the main problem we had with Matthew.He was misdiagnosed because he didnt present the classic symptoms that an adult with arthritis would.

One pediatrician told Matthews family that he was just suffering from growing pains, adding that joints would be red and warm to the touch or even swollen if the condition was more serious.

Now, none of his joints get visibly swollen. Only his knees do.

Following the pediatricians diagnosis, the family searched for more answers. Matthew was tested for muscular dystrophy by a pediatric neurologist. Christine said the neurologist told the family that Matthew suffered from a case of cerebral palsy that was never properly diagnosed as an infant.

An orthopedic surgeon followed. Christine said the surgeon serial-casted Matthew for three weeks, due to being convinced the pain and stiffness were caused by tight heel cords.

The real problem was the arthritis was now in his ankles and serial casting literally froze them in that position, she said. By the time he got out of the casts he could barely walk and was in extreme pain. He was told by kids that he walked like Frankenstein.

Even after years of physical therapy, the pain worsened. He couldnt run or play with the other children. When he tried to join a soccer team, the coach asked if he had clubbed feet due to how he walked and ran.

After being continually misdiagnosed by a variety of medical professionals including being suggested to test for both lupus and leukemia Matthew could barely get down the stairs at home due to his knees not being able to bend.

It was heartbreaking as a parent to see your child slowly lose all the things that brought them joy, she said. He was in constant pain and it really robbed him of a big part of his childhood.

After years of reading and researching the possible cause of her sons physical discomfort, Christine was the one who made the correct diagnosis: Her son had arthritis.

She and Matthew visited a pediatric rheumatologist, where blood work, an inflammation panel and an MRI were performed. Days before his 12th birthday, it was confirmed he had juvenile rheumatoid arthritis. Though by that time, years of incorrect medical opinions created joint damage and contractures that were irreversible.

Matthew had permanent limitations. Christine said her son has good days and bad days, and then some really bad days. He suffers from arthritis in his knees, elbows and ankles; pain and stiffness are in his wrists, fingers and hips.

There was a hope he would enter medicated remission, but that dream faded this past February, when he had an arthritic flare and was simultaneously diagnosed with Crohns disease.

Its believed that Crohns occurred after Matthew started taking a biological drug called Enbrel at the end of last summer. It was explained that patients who take Enbrel for arthritis are at risk of side effects of inflammatory bowel disease. Now, its another thing for Matthew to endure.

Many people dont realize that arthritis is not just an old persons disease, and its not just the pain and stiffness that is a daily struggle, Christine said. The side effects from these drugs are real, and so are the risks that come with taking them.

Its heartbreaking as a parent to wonder what kind of future your child is going to have.I worry, will the damage to his body be from the arthritis, or from the drugs he has to take to control the disease?

Walking in solidarity Matthews condition affected his family and friends in a profound way.

Christine said Matthew never wanted to come across as a victim, and he hates being the center of attention. He doesnt even like bringing up his ailments, she added, or talking to the media.

Bringing awareness to the issue is important for him, however, and his old school has provided a positive avenue for Matthew to feel endeared while simultaneously helping to fight the diseases that literally cripple his body.

On May 13, at the Detroit Zoo, the 2017 Detroit Walk to Cure Arthritis will take place. As of press time, 17 friends and former classmates of Matthews at the Arts Academy in the Woods in Fraser were scheduled to walk in the event.

Christina Martin, parent liaison at Arts Academy in the Woods, is also a longtime friend of Christine Dantes. Martins kids grew up with Matthew. When Dantes told Martin that Matthew who normally walks every year possibly wasnt going to make the event, she took matters in her own hands.

She began to raise funds, sharing information through Facebook and the Arthritis Foundation. Money was raised for Arts Academy students participating in the walk, including bags filled with special items.

Now, there are approximately 13 walkers and four backups as part of the group Movin for Matthew.

Just this past year things have really been tough, Martin said. (Matthew) was going through so much. I thought it would be kind of a cool idea for us to do it in his name.

After losing 20 pounds and spending nearly his entire second semester of college homebound, Matthews inflammation is being properly controlled through medication. Hes on high doses of prednisone, which is temporary, and a biological drug called Humira.

We are hoping his medications continue to keep his inflammation down, Christine said. If they do, and I really hope they should, Matthew will be able to participate in the walk.

I dont want to mislead anyone and make them think that Matthew is worse than he is right now.He is definitely doing better and whether or not it stays that way is to be determined, but right now we are counting our blessings.

For more information on the walk, visit walktocurearthritis.org.

About the author

Nick Mordowanec covers Fraser, Clinton Township, Fraser Public Schools, Clintondale Community Schools and Baker College for the Fraser-Clinton Chronicle. Nick, a graduate of Michigan State University, has worked for C & G Newspapers since 2013 and has won awards from the Society of Professional Journalists Detroit Chapter and the Michigan Press Association. He has slight obsessions with Seinfeld and Led Zeppelin.

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AJ Foyt on fear, his stem cell therapy and more – Indianapolis Star

May 10th, 2017 9:42 pm

The Indy 500 legend has been through several highs and lows recently. Clark Wade/IndyStar

Indianapolis 500 legend A.J. Foyt.(Photo: Clark Wade/IndyStar)Buy Photo

Its been a long and wild ride, and A.J. Foyt has enjoyed nearly every second of it.

I had a lot of fun, the 82-year-old racing legend told IndyStar on Wednesday at his racing garage in Speedway. If I passed out talking to you right now and fell on the floor, at least I made good money, had a happy life and what else can you ask for? So many people are so miserable with their jobs and that. I had a wonderful job doing what was fun.

Foyts job driving into racing's history books provided him with a lifetimes worth of close friends, amazing stories and thrilling adventures. But it also often required him to put his life on the line.

"I guess I was a little bit crazy back in those days,"Foyt, who walks with a limp but without assistance, said with a smile.

But being crazy was part of the job, he said. He needed it to overcome his fears.

"A lot of race drivers you talk to these days say they've never been scared in racing," Foyt said. "Well, they're lying to you and they're lying to themselves. I cannot name you one race at one time or another thatI didn'tscare the hellout of myself. Honestly. I don't know if that's good or bad, but I'm just being honest with you."

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Despite thosehealthy fears, his long and prestigious racing career resulted ina laundry list of injuries and eventual ailments that would and have horrifieddoctors.

The four-time Indianapolis 500 champion has stared death and dismemberment in the face more times than hed care to count, dealing withcar wrecks, killer bees, a bulldozer accident, heart ailments and two staph infections. As a result, hes nearly had his feet amputated,broken his back two or three times, has two false knees and a false hip, a titanium plate in his chest from open heart surgeryand said hell be on antibiotics for the rest of his life because of the amount of metal he has inside of him.

But he's far from discouraged and fightsto keep going with the same vigor and courage the colored his youth. One way he's done so recently is by undergoing stem cell therapy.Foyt said his wife, Lucy, who suffers from diabetes and arthritis, suggested that they both take on the treatment in order to try and find "the fountain of youth."

I mainly did it for her, Foyt said. She got sugar diabetes real bad, and (is) pretty sick, but, of course, I did it for myself too, dont get me wrong. But shes really been suffering the last five or six years. So we just thought wed try it.

A.J. and Lucy Foyt spent seven days in Cancun, Mexico the treatment is not performed in the United States undergoing a therapy he said likely wont take effect for another month at least. A.J. Foyt had adult stem cells injected into each shoulder and ankle, as well as into his blood.

Theres no guarantees the treatment will help either of them, but the uncertainty doesnt bother him.

I figure if we gain something, fine, and if we dont, well, Ive lost before," Foyt said.

But giving Foyt an edge in his fight against injury, ailment and Father Timeis a competitive fire that has burned within him his whole life.

A little more than a month ago, Foyt and fellow driving legend Dan Gurney were honored in Long Beach, Calif., for the 50th anniversary of their all-American victory at 24 Hours of Le Mans. Many racing greats attended the event, and Foyt was happy to see them, but he couldn't help but stackhimself up one more time against his old rivals.

I guess Im doing better than them, Foyt said with a smile. Poor Parnelli (Jones) has a lot of back trouble. Dan was in a wheelchair. Last three or four years Ive been going in and out of them, but Im still going pretty strong. So far Im hanging in there pretty good. ...Every days a good day. And Iguess thats good when youre getting ready to kick."

Follow IndyStar Motor Sports Insider Jim Ayello on Twitter and Instagram: @jimayello.

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Never get another filling? Drug helps regrow your teeth | FOX13 – FOX13 Memphis

May 9th, 2017 8:44 pm

Updated: May 9, 2017 - 6:06 PM

FOX13 consumer advisor Clark Howard says new research shows there may be a way to fill cavities by re-growing part of the tooth itself.

Fillings are one of the most common and least expensive dental procedures in America.

JohnSiewekeis the Dental Director at Good Samaritan Health Center in Atlanta. He says while common, fillings are also technique sensitive.

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If you do not follow that technique then you aregonnaget leakage between the tooth and the filling and that'sgonnalead to more decay and more break down and potential pain,Siewekeexplained. Depending on how far that is allowed to go could lead to the loss of the tooth.

Now a team of researchers at Kings College in London think theyve found a way to fill cavities, by stimulating a process that already takes place naturally when a tooth is damaged.

Teeth are a mineralized organ. Highly complex, they contain 2 different types of mineral; the enamel, which is the stuff on the outside that you see and underneath they have another mineral called dentine and right in the middle they have a soft tissue which has got blood supply and nerves, Paul Sharpe said.

Sharpe explained that when damage occurs, stem cells in the pulp are activated and begin the process of producing Dentine to repair the tooth, but it only works when the damage is small.

When the damage is big it just can't cope, the process is not robust enough to repair big holes ... i.e., when a dentist has drilled out decay, he said.

Thats where Tideglusib comes in. Sharpe and his team used the drug to stimulate the process of dentine production in mice.

They placed a small amount of the drug on a sponge and inserted it in the tooth of a mouse where a hole was drilled. The result, Sharpe said, was a massive stimulation of the natural process.

So you get dentine formed and it completely fills the tooth, Sharp said. So the hole that's drilled is now filled with the natural material that's been removed that the tooth has created itself.

It took two to four weeks for the dentine to grow back. Sharpe says its a strong natural repair that could prevent more damage down the road.

Failure with the conventional treatment where you are using cement is that the cement can crack, Sharpe explained. You can get fissures and that can lead to a reinfection of the tooth and there you have to go back to the dentist and have a new one put in.

According to the National Association of Dental Plans, 114 million in the U.S. had no dental coverage at the end of 2016, so making sure new treatments are affordable is key.

Thats one of the reasons Sharpe and his team chose Tideglusib.

It had already been used in patients for treatments in neurological disorders such as Alzheimers, he said. So that means this drug has been used systemically into the bloodstream at high concentrations ... and there is safety data ... so all the costs of drug development -- safety trials and everything else -- we don't have those. That's why I think among other things it could be cost-effective treatment.

Its also a relatively simple process, which also helps to keep cost down.

It's very uncomplicated, Sharpe said. Dentistry is massively high volume/low cost treatment -- so anything that's really over-complicated and expensive is never going to make the market.

It will still be about two years before there are human trials, but Sharpe stresses that even if this treatment goes mainstream, the drug is only meant to repair damage.

Sieweke agrees and says prevention is the best way to keep your dental costs down.

I think a lot of times that is getting lost in the real day-to-day treatment world. The focus is, What's broken? How do we fix it? And unfortunately too often also, What's the cost? And the cheapest way to bring down the cost of dental care is to prevent it, Sieweke said.

Clark says hes excited for the future.

You never know with science, but I think this one is the real deal for your mouth and mine, Clark said.

The best way to keep your dental bill down is to brush your teeth. Do you know how to do it correctly? Clark recently learned that he did not.

2017 Cox Media Group.

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International Stem Cell Corporation Receives Approval to Start Second Patient Cohort in Clinical Trial for Parkinson … – P&T Community

May 9th, 2017 8:44 pm

United News of India
International Stem Cell Corporation Receives Approval to Start Second Patient Cohort in Clinical Trial for Parkinson ...
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CARLSBAD, Calif., May 09, 2017 (GLOBE NEWSWIRE) -- International Stem Cell Corporation (OTCQB:ISCO), a California-based clinical stage biotechnology company developing stem cell-based therapies and biomedical products, today announced that that the ...
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Vitamin C can kill cancer stem cells, study shows – Kashmir Watch

May 9th, 2017 8:44 pm

CANCER is currently one of the top killers worldwide, and the number of cancer cases is only expected to rise. Although there are a number of therapies available, most of them are toxic and cause serious side effects. New research examines the impact of the natural vitamin C on cancer cell growth.

In a recent study, vitamin C proves effective in killing cancer stem-like cells. Cancer is the second leading cause of death and disease worldwide, accounting for almost 9 million deaths in 2015, according to the World Health Organization (WHO).

The global number of new cases of cancer are expected to grow by around 70 percent in the next 20 years. In the United States, the National Cancer Institute (NCI) estimate that almost 40 percent of U.S. men and women will have developed cancer at one point during their lives. There are various treatment options available for cancer, but they are not always effective; most of them are toxic, and they tend to have a variety of side effects.

In some more aggressive cases, the cancer does not respond to treatment, and it is believed that cancer stem-like cells are the reason why the cancer comes back and metastasizes. New research, published in the journal Oncotarget, examines the effectiveness of three natural substances, three experimental drugs, and one clinical drug in stopping the growth of these cancer stem cells (CSCs.)

The study was conducted by researchers from the University of Salford in Manchester in the United Kingdom, and was led by Dr. Gloria Bonuccelli.

In total, the researchers measured the impact of seven substances: the clinical drug stiripentol, three experimental drugs (actinonin, FK866, and 2-DG), and three natural substances (caffeic acid phenyl ester (CAPE), silibinin, and ascorbic acid (vitamin C).) The research focused on the bioenergetic processes of CSCs, which enable the cells to live and multiply. The study aimed to disrupt the CSCs metabolism and ultimately prevent their growth.

Of all the substances tested, the team found that actinonin and FK866 were the most effective. However, the natural products were also found to prevent the formation of CSCs, and vitamin C was 10 times more effective than the experimental drug 2-DG. Additionally, the study revealed that ascorbic acid works by inhibiting glycolysis the process by which glucose is broken down within the cells mitochondria and turned into energy for the cells proliferation.

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Brandon family appealing for stem cell match to cure girl’s sickle cell disease – CBC.ca

May 9th, 2017 8:44 pm

DorcasAdetudimu, like the average 12-year-old girl, likes to dance, play the piano and sing. Buta rare disease means she can't do those things for very long without getting sore and tired.

Her family is now appealing to the city of Brandon for help findinga stem cell match so she can have a chance at a normal life.

Adetudimuwas diagnosed with sickle cell disease when she was just six weeks old. The condition, common among those of African descent, is a gene mutation that causes the red blood cells to take a crescent shape, making it hard for oxygen to flow around the body.

"I can't do some things that other kids can do," she said, adding that something as simple as going for a swim can cause her body to go into crisis.

"I feel like I'm very limited to doing stuff," said Dorcas. The condition has led to severe pain and regular hospital stays that sometimes last for weeks at a time.

Her condition has worsened over the years. She now requires blood transfusions every four weeks. Last November, she was admitted to the intensive care unit at a Winnipeg hospital and put into an induced coma while doctors deflated her lungs and transfused all of her blood.

This June 2014 image provided by the National Institutes of Health, shows red blood cells in a patient with sickle cell disease at the National Institutes of Health Clinical Center in Bethesda, Md. (The Associated Press)

"It's a painful thing to see your child in pain," said her mom, Juliette. "That was the worst crisis she has ever had. She'd never been in the ICU before."

Juliette, who is originally from Nigeria but moved to Brandon five years ago with her four children, was told the only chance her daughter would have at a normal life would be through a stem cell transplant. Unfortunately neither Juliette nor any of her three other kids were a match.

"I thought that was it," she said. Adetudimu knows of only two other people in Brandon with sickle cell disease, which is rare in Manitoba and Canada, but common in African nations.

With the help of a family friend, Juliette started organizing a stem cell drive through Canadian Blood Services. She's hoping to get as many people as possible between the ages of 17 and 35 to register and submit a cheek swab on May 17 at the Shopper's Mall in Brandon in the hope of finding a match locally.

Since word of the drive got out, complete strangers have been contacting her wanting to help in any way they can.

"It [is] so overwhelming," Juliette said. "I didn't realize people were going to respond this way."

She said a neighbour, who she hadn't met before, showed up on her doorstep asking how he could help.

"Its encouraging to see this kind of support from people that you don't even know."

She's hoping to not only find a match for her daughter, but to also educate the city's ethnic community, and the public, about sickle cell and the importance getting on the stem cell registry.

"Even if they don't match Dorcas, they can still match with somebody else," she said.

Until a match is found, Dorcas will need frequent transfusions. Juliette isn't losing hope.

"I believe in miracles. Nothing is impossible," she said. "I am hopeful ... [a match] would change everything for Dorcas and the family."

The stem cell drive takes place at Brandon's Shopper's Mall on May 17 between noon and 9 p.m.

Dorcas (bottom right), with her mom and three other siblings in their Brandon, Man., home. None of her family members tested positive as a stem cell match for Dorcas. (Riley Laychuk/CBC)

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This is what your gritty eyes could mean – Express.co.uk

May 9th, 2017 8:43 pm

GETTY

Blepharitis - also known as lid margin disease - is a potentially sight-threatening ocular condition, but only one in four British people know it exists.

Despite the fact it can lead to ulceration of the cornea and permanent damage to vision, there are many people who remain undiagnosed with the condition.

According to Moorfields Eye Hospital, one in six people in the UK displays symptoms.

Signs include crusty deposits around the lashes, gritty and painful eyes, and irritation around the eyelids.

GETTY

Burning or gritty eyes can lead to the condition, which accounts for one in 20 GP appointments for eye problems.

Abnormal eyelash growth, finding contact lenses uncomfortable to wear, and increased sensitivity to light are also indicators.

Burning or gritty eyes can lead to the condition, which accounts for one in 20 GP appointments for eye problems.

Experts believe it is being fuelled by insomnia, sugary diets, air conditioning and spending long hours at a computer screen.

However, according to a survey by eye-care specialists Bausch + Lomb, two in five people have no idea what causes it.

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Ole Henriksen Ultimate Lift Eye Gel, 35 (0207 235 5000) Avoid if you have sensitive eyes because the gel can sting the first few times you apply it. Eyes do appear less puffy after a weeks use though. 6/10

GETTY

They also found 40 per cent of us have no idea how to manage it.

But if its not treated, or does not respond to therapy, it can lead to blindness.

While it cant be cured, you can control the symptoms and prevent permanent scarring of the eyelid margins, according to the NHS.

Francesca Marchetti, leading ocular expert and a member of the WINK advisory eye-care panel, said: Given how many people are affected by blepharitis, and the implications for vision if it is not managed effectively, these findings are extremely worrying.

GETTY

The first line treatment for blepharitis is using a combination of heat therapy, eye massage and good eyelid hygiene every day, this will manage the condition and in many cases will prevent further flare-ups.

A combination of cleansing the eyelids with special wipes and heat therapy can help.

The National Institute for Health and Care Excellence (NICE) advises: Eyelid hygiene is essential and this should be continued even when symptoms are well controlled.

They suggest applying a warm wipe to the closed eyelids for 5 to 10 minutes to loosen the debris and softens any deposits of meibum, an oily substance which protects the tear film but can problematic if the meibomian glands are blocked, or the meibum is too waxy.

Marchetti added: To have a therapeutic benefit, the heated compress must be a consistent 40 to 45C, and remain at that temperature for at least five minutes. But if it is any higher, or there are more intense hot-spots, there is a very real risk of burning or damaging the sensitive tissues around the eye.

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Hundreds to pull cargo plane to fight blindness – Mississauga

May 9th, 2017 8:43 pm

Mississauga
Hundreds to pull cargo plane to fight blindness
Mississauga
Hundreds of enthusiasts will be pulling a giant 60-ton cargo plane later this month to fight blindness and help restore vision to millions of people across the globe. Orbis Canada, a Canadian organization that works to deliver accessible quality eye ...

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