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Jack Friedges named Arthritis Foundation 2017 Young Adult Honoree – SW News Media

March 1st, 2017 7:47 am

Jordan High School senior Jack Friedges will serve as the 2017 Walk to Cure Juvenile Arthritis Young Adult Honoree this weekend at the Mall of America.

Walk to Cure Juvenile Arthritis brings together communities nationwide to fight arthritis the nations leading cause of disability.

In the U.S., more than 50 million adults and 300,000 children live with arthritis. Costing the U.S. economy $156 billion dollars a year, arthritis affects one in five Americans and causes more activity limitation than heart disease, cancer or diabetes.

Friedges, age 17, was diagnosed with juvenile idiopathic arthritis (JIA) in 2014. His parents believe he had signs of JIA throughout his childhood but attributed them to other causes. Friedges was very active; he was and continues to be a three-sport athlete playing football, basketball and his favorite sport, baseball.

At age 13, Friedges started complaining about odd sensations in his hands and that his fingers were big, fat and did not work. Friedges and his parents thought his sore hands were related to his active life.

Eventually, Friedges mom started noticing more and more that he was not using his hands. His brother would change the fishing line for him, he had trouble tying his shoes or buttoning his shirts and she saw how much Friedges was relying on his brother to do these tasks for him. Over several months, Friedges was officially diagnosed with JIA and his pain started to intensify and spread to his hands, feet, knees, elbows, shoulders and back.

Although Friedges optimistic attitude was unbeatable, it was a difficult time for their family. After six months of pain, Friedges medication started working and his pain and swelling decreased dramatically. Friedges has taken charge of his health, learning about his medication side effects and what triggers swelling or pain.

He does all this while being the most positive member of our family when it comes to this diagnosis, says Friedges mom. His strength to move on, stay positive and be in control of his life is astonishing.

Friedges, as the Young Adult Honoree, and his family want to help raise money for a cure as well as spread awareness about JIA. They may be uncertain of Friedges future but appreciate the resources, education and hope that the Arthritis Foundation has provided them. They are positive that JIA will not define Friedges future and he will be the champion of his own life.

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Marine Oil Supplementation for Rheumatoid Arthritis – Clinical Pain Advisor (registration)

March 1st, 2017 7:47 am

Clinical Pain Advisor (registration)
Marine Oil Supplementation for Rheumatoid Arthritis
Clinical Pain Advisor (registration)
Because rheumatoid arthritis (RA) is characterized by chronic inflammation, it is not surprising that researchers have long been interested in whether omega-3 supplements can improve RA symptoms. In a review article, Dr Tedeschi and associate Karen ...

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Medical Marijuana Market Analysis By Application, (Chronic Pain, Arthritis, Migraine, Cancer) By Country (US, Canada … – Yahoo Finance

March 1st, 2017 7:47 am

NEW YORK, Feb. 28, 2017 /PRNewswire/ -- The global medical marijuana market is expected to reach a value of USD 55.8 billion by 2025, according to a new report by Grand View Research, Inc. It has been identified that, in 2016, Washington D.C. along with 28 states have legalized marijuana for medical uses. In 2016, states such as Arkansas, Florida, North Dakota, Ohio, and Pennsylvania were approved to use the drug in medical applications such as chemotherapies and pain management. The growing number of states and countries getting approval for using it in therapeutic applications is one of the crucial factors driving the demand over the coming few years.

The presence of several regulatory frameworks such as the Medical Marijuana Regulation and Safety Act is indicators of the present demand for the drug in the market. The regulatory framework requires every individual or the company associated such as growers, retail operators, and makers of processed pot products to obtain permission and an annual state license from 2018. An increasing number of issued licenses is also among factors that is expected to drive the market especially after 2018.

The increasing interest amongst the academic researchers and healthcare providers regarding the therapeutic uses of marijuana is among the significant factors, which is driving the market over the coming years. Some of its potential therapeutic values are suppression of vomiting & nausea, pain relief, and appetite stimulation. In addition, research states that marijuana is effective in providing relief to the patient suffering from HIV/AIDS, glaucoma, cancer, and multiple sclerosis. The growing number of therapeutic applications of the drug is one of the key factors that is propelling the market over the forecast period.

Further key findings from the study suggest:

In 2015, chronic pain was the largest application segment owing to the presence of a huge patient base

The growing prevalence of chronic pain elevates the demand for the drug, thus expected to boost the medical marijuana for chronic pain management

The rapidly growing number of cannabis legalization in the U.S. is one of the key attributes for its increased demand in therapeutic and recreational uses, and thus anticipated to impel the market growth

Increasing investment in R&D & demand for cannabis in chemotherapy is expected to drive the growth in the Asia Pacific market

Some of the key players are Cara Therapeutics Inc.; CannaGrow Holdings, Inc.; Cannabis Sativa, Inc.; United Cannabis Corporation; GrowBlox Sciences, Inc.; GW Pharmaceuticals, plc; Lexaria Corp; International Consolidated Companies, Inc. Read the full report: http://www.reportlinker.com/p04717523-summary/view-report.html

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Stem cell treatment changed the life of one guest at Trump’s speech – CNN

March 1st, 2017 7:47 am

She credits an experimental stem cell treatment with giving her new hope for her health and her future -- a newfound hope that also caught attention of Republican Rep. Pete Olson.

"She is the face of the 21st Century Cures Act because of what she's gone through in her life," he said Tuesday.

"It became pretty clear to me that ... I (have) got to tell her story," he said. "That's why she's here: She's awesome."

Immediately after the House vote, Hughes said, Olson called her at home to invite her to be his guest of honor.

"I still cannot believe I will be in the same room as our President and lawmakers," she said before attending Trump's speech.

It took Crowley's father, John, to launch the New Jersey biotechnology company Amicus Therapeutics to identify a drug treatment that would save her life, Trump said.

"If we slash the restraints, not just at the FDA but across our Government, then we will be blessed with far more miracles like Megan," he said. "In fact, our children will grow up in a Nation of miracles."

Hughes spent most of her adolescence hospitalized, as she became so sick that she could barely walk and suffered immense pain. Her body was evaluated, treated and studied at the National Institutes of Health in collaboration with her doctors from the University of Texas Health Science Center at Houston.

Yet relief came in 2014, when Hughes received a high-dose adult stem cell treatment that was not approved in the United States.

For the procedure, Hughes had her own healthy stem cells cultured at the FDA-registered biotechnology company Celltex Therapeutics in Houston. Then she traveled to Cancun, Mexico, to have the cells infused back into her body.

Each infusion involved about 200 million stem cells, and Hughes received some 22 infusions over almost two years. The cells could help normalize her immune system, which was overactive due to her autoimmune disease.

Before the stem cell therapy, Hughes said, she was taking 23 medications a day. Now, she is on eight medications at lower doses.

"If not for the help of high-dose autologous mesenchymal stem cell therapy, I would not be here today," Hughes said at the hearing.

"I was running out of time, but I was willing to put my life at risk to get on an airplane. My quality of life had become so dismal, even one small improvement from my own stem cells would have been enough for me," she said in her speech. "What happened in the days, weeks and years following my first infusion has changed my outlook. It's hard to believe, in my sick body, I had a wealth of healthy adult stem cells with the ability to so significantly improve my quality of life."

"My hope is that our new President will spend time looking at how to help all Americans have access to new therapies like the one I had," she said.

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Stem Cell Therapy Market Worth 145.8 Million USD by 2021 – Yahoo Finance

March 1st, 2017 7:47 am

PUNE, India, February 28, 2017 /PRNewswire/ --

According to a new market research report "Stem Cell Therapy Market by Type (Allogeneic, Autologous), Therapeutic Application (Musculoskeletal, Wound & Injury, CVD, Surgery, and aGVHD), Cell Source (Adipose tissue, Bone Marrow, Neural, Embryo/Cord Blood derived, iPSCs) - Global Forecasts to 2021" published by MarketsandMarkets, the market is expected to reach USD 145.8 Million by 2021, growing at a CAGR of 11.0%.

(Logo: http://photos.prnewswire.com/prnh/20160303/792302 )

Browse 60 market data Tables and 37 Figures spread through 120 Pages and in-depth TOC on "Stem Cell Therapy Market"

http://www.marketsandmarkets.com/Market-Reports/stem-cell-technologies-and-global-market-48.html

Early buyers will receive 10% customization on this report.

The report analyzes and studies the major market drivers, restraints, opportunities, and challenges in North America, Europe, Asia-Pacific, and the Rest of the world (RoW) for the forecast period of 2016 to 2021. Factors such as the growing awareness related to the therapeutic potency of stem cells in disease management, development of advanced genome-based cell analysis techniques, increasing public-private investments for stem cell research, identification of new stem cell lines, and developments in infrastructure for stem cell banking and processing are propelling the growth of the global Stem Cell Therapy Market.

On the basis of type, the global Stem Cell Therapy Market is divided into two major categories, namely, allogeneic stem cell therapy and autologous stem cell therapy. The allogeneic stem cell therapy segment is expected to command the largest share in the global Stem Cell Therapy Market in 2016. This large share can primarily be attributed to the rising commercialization of allogeneic stem cell therapy products, wider therapeutic applications of allogeneic stem cells, easy production scale-up process, and growing number of clinical trials related to allogeneic stem cell therapies.

Inquiry Details: http://www.marketsandmarkets.com/Enquiry_Before_Buying.asp?id=48

On the basis of therapeutic application, the global Stem Cell Therapy Market is segmented into musculoskeletal disorders, wounds and injuries, cardiovascular diseases, surgeries, gastrointestinal diseases, and other applications. The musculoskeletal disorders segment is expected to command the largest share of the global Stem Cell Therapy Market in 2016. This large share can be attributed to the rising availability of stem cell-based products for the treatment of musculoskeletal disorders, high prevalence of musculoskeletal disorders and bone & joint diseases, and growing patient preference for effective & early treatment strategies.

North America is expected to be the largest regional segment in the global Stem Cell Therapy Market in 2016, followed by Asia-Pacific. In addition, the North American Stem Cell Therapy Market is expected to be the fastest growing region during the forecast period. Factors such as growing awareness related to the therapeutic potency of stem cells, increasing number of clinical trials for stem cell-based products, and increasing public-private funding & research grants are driving the growth of this market.

Download PDF Brochure: http://www.marketsandmarkets.com/pdfdownload.asp?id=48

As of 2015, Osiris Therapeutics, Inc. (U.S.), MEDIPOST Co., Ltd. (South Korea), Anterogen Co., Ltd. (South Korea), Pharmicell Co., Ltd. (South Korea), Holostem Terapie Avanzate S.r.l. (Italy), JCR Pharmaceuticals Co., Ltd. (Japan), NuVasive, Inc. (U.S.), RTI Surgical, Inc. (U.S.), and AlloSource (U.S.) are some of the key players operating in the global Stem Cell Therapy Market.

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Stem Cell Assay Market by Type (Viability, Differentiation, Cell Identification), Kit (Mesenchymal, IPSCS, Hematopoietic), Product (Flow Cytometer, Detection Kit), Application (Regenerative Medicines, Drug Development), End User - Forecast to 2021

http://www.marketsandmarkets.com/Market-Reports/stem-cell-assay-market-47610330.html

Stem Cell Banking Market by Bank Type (Cord Blood, and Cord Tissue), Service (Collection & Transportation, Analysis, Processing, and Storage), Application (Cerebral Palsy, Leukemia, Thalassemia, Anemia, Autism, Diabetes), Region - Forecast to 2021

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About MarketsandMarkets:

MarketsandMarkets is the largest market research firm worldwide in terms of annually published premium market research reports. Serving 1700 global fortune enterprises with more than 1200 premium studies in a year, M&M is catering to a multitude of clients across 8 different industrial verticals. We specialize in consulting assignments and business research across high growth markets, cutting edge technologies and newer applications. Our 850 fulltime analyst and SMEs at MarketsandMarkets are tracking global high growth markets following the "Growth Engagement Model - GEM". The GEM aims at proactive collaboration with the clients to identify new opportunities, identify most important customers, write "Attack, avoid and defend" strategies, identify sources of incremental revenues for both the company and its competitors.

M&M's flagship competitive intelligence and market research platform, "RT" connects over 200,000 markets and entire value chains for deeper understanding of the unmet insights along with market sizing and forecasts of niche markets. The new included chapters on Methodology and Benchmarking presented with high quality analytical infographics in our reports gives complete visibility of how the numbers have been arrived and defend the accuracy of the numbers.

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Stem cell therapy can help treat diabetic heart disease – The … – Economic Times

March 1st, 2017 7:47 am

KARAIKAL: Recent advancements in stem cells research have given hope for successfully treating diabetic heart disease (DHD), renowned New Zealand-based researcher in cardiovascular diseases Dr Rajesh Katare said today.

DHD affected the muscular tissues of the heart leading to complications and it had been demonstrated that resident stem cells of myocardium can be stimulated to repair and replace e degenerated cardiac myocytes resulting in a novel therapeutic effect and ultimately cardiac regeneration, he said.

Katare, Director of Cardiovascular Research Division in the University of Otago, New Zealand, was delivering the keynote address at the continuing medical education programme on "Role of Micro-RNAs and stem cells in cardiac regeneration in diabetic heart disease" at the Karaikal campus of premier health institute JIPMER.

Presenting clinical evidences, Katare said stem cell therapy certainly presented a new hope for successfully treating DHD.

Jawaharlal Institute of Post Graduate Medical Education (JIPMER) Director Dr Subash Chandra Parija pointed out that it was the first such programme on the role of stem cells in cardiac regeneration in the whole of the country.

He said as diabetes was highly prevalent in the country, providing treatment for DHD had become a big challenge. Patients suffering from the condition have to undergo lifelong treatment and medications. "In this backdrop, advancements in stem cell therapy assume significance," he said.

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AstraZeneca Shares Rise After FDA Approval for Type-2 Diabetes Treatment – TheStreet.com

February 28th, 2017 6:51 am

AstraZeneca (AZN) stock gained in early London tradingTuesday after it received approval from the U.S. Food and Drug Administration for a type-2 diabetes medication.

The London-listed drugmaker said it had received approval for Qtern, a once-daily treatment for type-2 diabetes, which affects more than 29 million American. The approval comes after the company's breast cancer treatment, Lynparza, was shown to be more effective than chemotherapy.

AstraZeneca shares were marked 1.07% higher at 4,658 pence each by 08:45 GMT, extending a 9.46% gain in the past three months, largely in-line with the 8.9% advance for the Stoxx Europe TMI Pharmaceuticals Index.

"Type-2 diabetes is a complex disease that is at epidemic proportions ... The approval of Qtern is good news for patients who may benefit from improved glycaemic control by adding a DPP-4 inhibitor to a SGLT-2 inhibitor in a convenient once-daily tablet," said AstraZeneca's vice president and head of cardiovascular and metabolic diseases Elisabeth Bjork.

Qtern combines two anti-hyperglycaemic agents with complementary mechanisms of action in a once-daily tablet: Dapagliflozin, a sodium-glucose cotransporter 2 (SGLT-2) inhibitor; and saxagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor.

Diabetes is a core therapy area for the company, focusing on research and development efforts on diverse populations and patients with other disease such as cardiovascular disease, obesity, non-alcoholic steatohepatitis and chronic kidney disease.

The company earlier this month said that a new oncology treatment Lynparza has shown to be more effective than chemotherapy in treating metastic breast cancer.

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Fasting Diet for People With Diabetes Could Regenerate the Pancreas – A Sweet Life

February 28th, 2017 6:51 am

New research shows that a diet which mimics fasting might be able to push beta cells in the pancreas to repair themselves and start making insulin again.

BBC news reported that for the research study, mice in the lab were put on a modified form of the fasting-mimicking diet. The diet is similar to the human practice of spending five days on a low-calorie, low-protein, low-carbohydrate diet. It resembles a vegan diet with nuts and soups, but with around 800 to 1,100 calories a day. Then they have 25 days eating what they want so overall it mimics periods of feast and famine, says BBC news.

A press release on Eureka Alert explained that the researchers used two different mouse models of two types of diabetes to study how the diet affected the mice. One group had a gene mutation that causes insulin resistance and loss of insulin secretion, which mimicked type 2 diabetes. The other group was treated with a chemical to destroy the mices beta cells, which was the model for type 1 diabetes. Both groups were put on the diet for three cycles.

Excitingly, this diet showed the possibility of regeneration of insulin-producing cells in the pancreas which had stopped or slowed production of insulin in people with type 1 and type 2 diabetes, respectively.

Senior author of the study, Dr. Valter Longo of the University of Southern California School of Gerontology and Director of the USC Longevity Institute, told Eureka Alert, Our conclusion is that by pushing the mice into an extreme state and then bringing them backby starving them and then feeding them againthe cells in the pancreas are triggered to use some kind of developmental reprogramming that rebuilds the part of the organ thats no longer functioning.

Studies suggest the diet could be a way to reboot the body by inducing it to slow down aging and regenerating new cells, reports Eureka Alert.

Dr. Longo told BBC: Medically, these findings have the potential to be very important because weve shown at least in mouse models that you can use diet to reverse the symptoms of diabetes. Scientifically, the findings are perhaps even more important because weve shown that you can use diet to reprogramme cells without having to make any genetic alterations.

The intermittent fasting diet has been trialed on humans for various purposes, and it has shown improved blood sugar levels. However, people are advised not to try this diet on their own because it could have a detrimental impact on their health if not done with proper medical guidance.

A BBC reporter, Peter Bowes, took part in a separate trialwith Dr. Valter Longo several years ago .

Bowes told BBC: During each five-day fasting cycle, when I ate about a quarter of the average persons diet, I lost between 2kg and 4kg (4.4-8.8lbs).

But before the next cycle came round, 25 days of eating normally had returned me almost to my original weight. But not all consequences of the diet faded so quickly.

According to the BBC, his blood pressure was lower as was a hormone called IGF-1, which is linked to some cancers.

On February 15, Longos team published a Phase II study that was carried out in 100 humans who were exposed to three rounds of the same diet. According to Eureka Alert, their IGF1 levels decreased and their fasting glucose levels improved, among other findings.

However, the team says more research is needed before the findings can be validated for application in humans. Longo told Eureka Alert that future clinical trials are already being planned.

The research findings were originally published in the journal Cell.

Elizabeth Rowley is the Founder and Director of T1International. She was born in the United States and has lived with type 1 diabetes for 25 years. Elizabeth moved to London in 2011 to complete her Masters degree in International Development at the London School of Economics and Political Science and has worked with non-profits, diabetes and health organizations ever since. She believes that where you were born should not determine whether you live or die with diabetes, and she is confident that by working together we can find solutions to the complex problems faced by people with diabetes.

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Dealing with diabetes distress – Chicago Tribune

February 28th, 2017 6:51 am

People with diabetes have to think about their condition and make treatment decisions constantly and all that extra work and worry can lead to psychological distress at times.

"Diabetes distress" isn't the same as depression, diabetes experts note. It's a condition unique to the 24/7 demands that come with diabetes, particularly for people dependent on insulin.

"The day you develop diabetes, it's like the universe just handed you a new full-time job that you have to do in addition to whatever else you're doing. It's a special job that has a big impact on the rest of your life. There's no pay and no vacation," said William Polonsky, president of the Behavioral Diabetes Institute in San Diego.

RELATED: TRENDING LIFE & STYLE NEWS THIS HOUR

Alicia McAuliffe-Fogarty, vice president of lifestyle management at the American Diabetes Association, put it this way: "Diabetes distress is the extra burden that people with diabetes have to carry. They have to do everything that other people do take care of work, family, finances and in addition they have to make sure to check their blood sugar, remember to take their medicine and/or adjust their insulin doses, count carbohydrates when they eat.

"It's a day-to-day and minute-to-minute burden. It's doing everything 'right' and still seeing your blood sugar levels go up," she added.

Diabetes distress is a range of different emotional responses that come with dealing with the burdens of caring for diabetes, Polonsky explained.

"It's being fed up and overwhelmed with the demands and concerns of diabetes. It's feeling powerless in the face of diabetes. It's knowing that despite your best actions, sometimes those [insulin] numbers go up and down and it seems beyond your ability to influence. And it can negatively influence one's quality of life," he added.

The phenomenon hasn't been well-studied Polonsky said he and his colleagues are in the middle of a study on diabetes distress that will hopefully answer some questions about the condition that affects an estimated 30 percent of people with diabetes at some point in their lives.

"It's not everybody, and it's not all the time, but it's pretty darn common, and a whole lot more common than depression" among those with diabetes, Polonsky added.

Diabetes distress and other psychological conditions are common enough that the American Diabetes Association added a section to its guidelines, published recently in the journal Diabetes Care, suggesting that providers screen all of their diabetes patients for these mental health concerns.

Juggling job with no breaks

There are two main types of diabetes: Type 1 and Type 2.

People with Type 1 diabetes don't make enough insulin, a hormone the body needs to use the carbohydrates in food for fuel. Because of this, people with Type 1 rely on insulin injections or insulin delivered through a tiny catheter inserted under the skin and then attached to an insulin pump worn outside the body. People with Type 1 diabetes using shots may need five or six insulin injections daily.

In people with Type 2 diabetes, the body is no longer able to use insulin properly. Most (95 percent) of diabetes cases involve the Type 2 form. Sometimes, people with Type 2 diabetes also need to use insulin injections.

Using insulin is a difficult balancing act too much or too little can cause problems, even life-threatening ones. When blood sugar levels drop too low from too much insulin, people can become disoriented, and if levels drop even further, they may pass out. Blood sugar levels that are too high and left untreated over time can cause complications such as kidney troubles, eye problems and heart disease.

To keep track of blood sugar levels when using insulin, most people rely on glucose meters and a lancing device that pricks the finger to draw out a drop of blood. This may be done as few as 4 times a day, or as many as a dozen or more times daily, depending on how blood sugar levels are fluctuating.

Many factors besides insulin can influence blood sugar levels. Food, alcohol, physical activity, emotions such as stress, and illness all can cause unpredictable changes in blood sugar levels.

Strength in numbers

Both Polonsky and McAuliffe-Fogarty said it's important to recognize and treat diabetes distress because it can have a negative impact on blood sugar management.

"In some studies, diabetes distress can impact diabetes care more than depression," McAuliffe-Fogarty said.

Antidepressants aren't likely to help someone with diabetes distress, according to Polonsky.

McAuliffe-Fogarty suggests checking in with your health care provider so you can go over your current diabetes management regimen. It's possible that changes in your management might help, she said.

Or, it might help to have a visit with a diabetes educator to go over some of the basics again, she recommended. Many people with Type 1 diabetes are diagnosed as children, and as adults may not realize they're missing some of the basics of diabetes education.

"Maybe pick one or two things that would make the most impact on your management and focus on those one or two small things, and you'll likely achieve those goals. Then set one or two more goals and move along like that not everything needs to happen at once," McAuliffe-Fogarty said.

Both experts agreed that support is an important component of treating diabetes distress. "You don't want to do diabetes alone. If you have someone who's rooting for you, that really helps," Polonsky said.

He said parents or spouses can give a person with diabetes a break by taking over the management of the disease for a little while. It gives them a "diabetes vacation."

For some, distress can get more serious. McAuliffe-Fogarty said about one in every four or five people with diabetes will experience depression at some point.

She said signs that suggest you need to speak with a mental health professional include: changes in appetite and sleep patterns, having no interest in activities you once enjoyed, social isolation, feeling persistently sad or hopeless, and having a down mood on more days than not.

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Human neurons in mouse brains are more susceptible to Alzheimer’s pathology – Drug Target Review

February 28th, 2017 6:48 am

news

Cells behave differently when removed from their environments, just as cells that develop in cultures do not behave like cells in living creatures.

To study the effects of Alzheimers disease in a more natural environment, scientists from the lab of Professor Bart De Strooper (VIB-KU Leuven, Dementia Research Institute-UK) in collaboration with scientists from ULB (Professors Pierre Vanderhaeghen and Jean-Pierre Brion) successfully circumscribed this challenge by transplanting human neural cells into mouse brains containing amyloid plaques, one of the hallmarks of Alzheimers disease.

The results of their research showed that, unlike mouse neurons, human neurons that developed in this environment were extremely susceptible to Alzheimers disease.

The study of the development of Alzheimers disease on a molecular level presents unique challenges, as neurons behave differently in vivo vs in vitro. Using mice as models presents useful insights, but mouse models never fully develop the disease, despite the fact that their brains and neurons share many similarities with those of humans.

A team of researchers has now transplanted human neurons into mouse brains which mimic some of the hallmarks of Alzheimers disease, including the presence of amyloid plaques. They found that, compared to mouse neurons, human neurons were much more sensitive to amyloid plaque pathology.

This novel model allows for a better characterisation of the disease processes that actually take place in the brain of human patients.

Much of the work was performed in close cooperation with Professor Pierre Vanderhaeghen (ULB-WELBIO, VIB-KULeuven), whose lab previously pioneered the technology to differentiate human pluripotent stem cells into neural cells in vitro, and then transplant them in the mouse brain, generating a human/mouse chimera.

Professor Bart De Strooper (VIB-KU Leuven, Dementia Research Institute-UK), We relied heavily on the insights and expertise of Pierre Vanderhaeghen and his lab to set up this new AD model.

With this novel experimental technique, we can study how different cell types in the human brain respond to the Alzheimer pathology, hopefully unravelling the link between amyloid and tau protein pathology which leads to neuron death and is the holy grail of current Alzheimers research.

Professor Pierre Vanderhaeghen (ULB-WELBIO and VIB), While many features of the brain are conserved between different species such as humans and mice, the human brain displays a number of characteristics, which make us what we are, as a species and as individuals. However, studying this human-specific part remains a big challenge in neuroscience. This study is exciting because it constitutes a first proof of principle that stem cell-based models of transplanted human neurons can be applied to study an important neurological disease.

Moving forward, Professor De Strooper and his team are already planning a screen to identify human genes that protect against cell death associated with Alzheimers disease.

Professor Bart De Strooper (VIB-KU Leuven, Dementia Research Institute-UK), Now that we are able to investigate the disease by observing human cells directly, we can make progress in this field of research at a considerably faster pace.

The eventual end goal of the screening is to identify new drug targets within human cells themselves, something that was never possible before.

A breakthrough in research is not the same as a breakthrough in medicine. The realizations of VIB researchers can form the basis of new therapies, but the development path still takes years. This can raise a lot of questions. For any questions about the research please email: [emailprotected] Everyone can submit questions concerning this and other medically-oriented research directly to VIB via this address.

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Genetic clue to form of blindness could lead to early diagnosis – ABC Online

February 28th, 2017 6:48 am

Posted February 28, 2017 17:44:11

The first genetic indicator of an eye disease which results in blindness has been discovered by an international team of researchers.

The degenerative eye disease Macular Telangiectasia type 2, or MacTel, is incurable and usually strikes people who are over the age of 40.

Up until now identifying a possible cause for the disease has been difficult.

Scientists are unsure as to how many Australians have MacTel, but they estimate somewhere between 500 and 1,200.

The disease affects the macular the centre of the eye said Professor Melanie Bahlo, from the Walter and Eliza Hall Institute in Melbourne.

"What happens is blood vessels dissolve and start growing into the centre of the eye, and that leads to blindness," she said.

"And there's also the crystalline deposits that form."

This leads to a gradual loss of central vision over a period of 10 to 20 years, impacting people's use of their sharp vision for tasks like driving and reading.

There were also signs that there could be genetic predispositions for MacTel in certain people.

"You can get several family members [with the disease], in the worst case scenario," Professor Bahlo said.

"That usually means that there's a genetic basis to the disease."

To find out more, researchers collaborated with teams in London and New York to analyse the genetic data of nearly 500 MacTel patients, and 1,700 people without the disease.

Professor Bahlo said they carried out statistical analysis of DNA data from about 6 million markers in the genome of patients with the condition and then compared them to those without.

They found genetic similarities in five key regions of the genome.

Professor Bahlo said four of the five genome regions identified were connected with two crucial amino acids and the fifth region was connected with the size of blood vessels in the retina.

She likened the discovery of the five genetic risk locations to a "treasure map" and said scientists would now keep digging to find out more about the genes associated with MacTel.

Professor Bahlo said they hoped the discovery would eventually help identify people at risk of developing the eye disease.

"For the first time we know a pathway to investigate the future by medical research with future studies in the lab," she said.

"We'll try and validate those findings further. But we've also got some potential biomarkers which will help us diagnose the disease, which is difficult to diagnose, and just pinpoint people who may have faster or slower progression."

The study will be published in the journal Nature Genetics.

Topics: dna, science-and-technology, genetics, cloning-and-dna, eyes, diseases-and-disorders, health, medical-research, research, melbourne-3000, australia, vic

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Americans Are Terrified of Going Blind – Esquire.com

February 28th, 2017 6:48 am

Americans are a fearful lot. In 2016, one survey found 60 percent of Americans feared corrupt government officials, 41 percent feared a terrorist attack, and 35.5 percent were afraid of Obamacareall fears they channeled into an election. In a separate survey conducted at Johns Hopkins, a majority of Americans (47.4 percent) said loss of sight was the "worst possible" health problem someone could go through. Now, ironically, 56 percent of Americans are afraid they'll lose their health insurance. Blindness, for those keeping track, is often preventable with regular healthcare.

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In a study of 2,044 adults, blindness was ranked as more dreaded than loss of hearing, memory, speech, a limb, or contracting HIV/AIDS, according to The New York Times, because it would have the worst perceived effect on quality of life and a person's independence. Adult blindness is usually caused by four diseasescataracts, glaucoma, diabetes, and age-related macular degenerationthe signs of which can be detected pretty early on by an eye doctor.

With access to an ophthalmologist and a desire for preventative healthcare, that's one major American fear taken care offor now. Shall we tackle government corruption next?

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Schizophrenia Genes Reduce Rheumatoid Arthritis Risk And Vice Versa – IFLScience

February 28th, 2017 6:47 am

Schizophrenia and rheumatoid arthritis don't seem to have a lot in common, aside from being often debilitating conditions that each affect around 1 percent of the population. One is a psychiatric disorder and the other an auto-immune condition, but new research has confirmed there is a genetic trade-off between the two, with gene variations that make people more susceptible to one reducing the risk of the other. The work has identified eight genes that appear to play a role in this biological see-saw, providing opportunities to learn about both conditions.

We know that environmental conditions partially determine whether someone will suffer the confusion and false perceptions associated with schizophrenia or the joint pain caused by the body's immune system's attack on its own cells that defines rheumatoid arthritis. Nevertheless, both also run in families and are known to have a strong genetic component, estimated at 70 percent for schizophrenia.

Several previous research studies have hinted at a potential inverse relationship in the prevalence and risk for the two disorders, so we wondered if individual genetic variants may exist that could have opposing effects on the risk of schizophrenia and rheumatoid arthritis, said Professor Vishwajit Nimgaonkar of the University of Pittsburgh. The genetics of both diseases have been fairly well studied, so there was plenty of data for Nimgoankar and his colleagues to work with.

After searching through existing databases of alleles(gene variations), Nimgaonkar and colleagues found 18 that appear to raise the risk of one of schizophrenia or rheumatoid arthritis while lowering the other. All involved the change of one genetic letter of the most common form of eight genes from the section of our genome known to be control the functioning of the immune system.

In npj Schizophrenia, Nimgaonkar reports that two of these genes, HLA-B and HLA-C, encode proteins that appear in both the brain and cells of the immune system. It appears certain single nucleotide polymorphisms(SNPs) alter the production of proteins to improve the functioning of one aspect of the body at the expense of another, providing a level of protection against one disease while increasing risk for the other.

The HLA region has been thought to be related to both diseases for more than 40 years. Besides providing confirmation for these suspicions, Nimgaonkar's work will help future studies home in on the most relevant parts of our DNA.

Interventions that raise the risk of one condition while treating the other may be something of a devil's bargain, but it may be possible to tailor treatment to consider which condition poses more risk to an individual. Meanwhile, we have confirmation the immune system plays a role in schizophrenia, and a demonstration of the benefit of scientists looking outside their specialization.

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Stem cell therapy may be effective for multiple sclerosis – The … – Clinical Advisor

February 28th, 2017 6:46 am

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Stem cell therapy may be effective for multiple sclerosis - The ...
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Younger age, relapsing forms of MS, fewer prior immunotherapy treatments, and lower baseline EDSS score were factors associated with better outcomes for ...

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All eyes on Garrett Richards, in hopes stem cells stave off Tommy John surgery – USA TODAY

February 28th, 2017 6:46 am

With MLB spring training underway, there's plenty to talk about. USA TODAY Sports

Garrett Richards is aiming to pitch through a ligament tear via stem cell therapy and other recovery methods.(Photo: Rick Scuteri, USA TODAY Sports)

TEMPE, Ariz. Garrett Richards first thought when he found out about his torn elbow ligament last May was to schedule Tommy John surgery as soon as possible.

It made sense, considering the ligament-replacement procedure has become the standard fix for such injuries. Plus, the Los Angeles Angels ace was familiar with the operating room, having undergone surgery for a ruptured patellar tendon he sustained on Aug. 20, 2014, toward the end of a breakout season.

Richards knew how to handle the seemingly interminable months of rehab, and he wanted to get the clock started on his return.

But a conversation with Angels head physical therapist Bernard Li convinced Richards to consider other alternatives, and in mid-May he tried a relatively novel treatment in which stem cells taken from bone marrow in his pelvis were injected into the damaged area.

Richards did not pitch again the rest of the year except for a stint in the instructional league, but he has been back on the mound throwing bullpen sessions since the first day of the Angels camp and reported no problems.

This weekend, Richards anticipates pitching in a game for the first time since May 1, when his aching elbow forced him from a start after just four innings.

Its nice to know Ill be able to start the season this year and kind of pick up where I left off, Richards said.

A couple of lockers away, fellow starter Andrew Heaney had a different tale to tell.

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The promising left-hander also went down with a torn ulnar collateral ligament early in the season, after making only one start. Their ailments were the two biggest blows to an Angels rotation that was decimated by injuries, dooming the club to a 74-88 record and a fourth-place finish in the AL West.

Heaney also tried stem cell therapy, two weeks before Richards, both under the supervision of team doctor Steve Yoon. Heaneys ligament didnt heal, though, and after experiencing discomfort throwing following his rehab, he had Tommy John surgery July 1. He has been ruled out for the 2017 season.

They tell you its 50-50. It either works or it doesnt, Heaney said of the stem cell procedure. Obviously, me and Garrett are pretty much the proof of that rule.

Even with less-favorable odds than reconstructive surgery, which has an 80% success rate for returning to action and 67% for pitching 10 games or more, stem cell therapy is gaining acceptance as an option for pitchers with partial UCL tears. The recovery time is shorter 3-5 months instead of 12-18 and the treatment less invasive.

There are limitations. Biological approaches based on stem cells or platelet-rich plasma (PRP) wont repair a complete tear of the ligament. The location of the injury and its extent factor into the chances of success. And players whose ligament doesnt recover, then have to undergo surgery, extend their window of time for returning to action.

Even then, the idea of healing without going under the knife is becoming increasingly appealing. New York Yankees ace Masahiro Tanaka treated the small tear in his elbow ligament with PRP and rehabilitation in 2014, sitting out 10 weeks but coming back to pitch in late September.

Hes 26-11 with a 3.26 ERA over the last two seasons, raising the profile of PRP a procedure in which the players own blood is used to promote healing of the injury as a non-surgical alternative.

Now Richards looms as the test case for stem cell treatment to fix partial UCL tears, which make up about 60-70% of these injuries. If the hard-throwing right-hander can return to his old form he was a Cy Young Award candidate before his knee injury in August 2014 other pitchers in his situation are bound to at least consider the route he took.

I hope this opens another path for guys, Richards said. Obviously, if you can prevent being cut on and having surgery, thats the No. 1 priority. I hope guys dont just jump right into Tommy John, that they at least explore this option.

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Ageless veteran Bartolo Colon was the first pitcher widely known to have undergone stem cell therapy as he sought to recover from elbow and shoulder ailments in 2010. At the time, the ethics of the procedure were questioned, especially because the doctor who performed it, South Florida-based Joseph Purita, acknowledged using human growth hormone in previous treatments, though not in Colons.

Since then, the use of stem cells has become more mainstream. They are the focus of Yoons practice.

As more and more people start to use it, youre getting a better sense for what it can and cant do, Yoon said. Baseball definitely has opened up to it quite a bit, and as we see some of the successes like with Garrett, were getting a better understanding that theres a lot of potential here with these types of treatment.

Yoon calls stem cell therapy a super PRP because it combines the curative properties of that treatment with more healing agents, and said it can be used on tendon tears, muscle tears and strains and even to address degenerative joint disease.

However, much remains unknown about the benefits of stem cells. Lyle Cain, an orthopedist who has performed both Tommy John surgeries and stem cell treatments at the Andrews Sports Medicine & Orthopaedic Center in Birmingham, Ala., said most of the research has been anecdotal, not scientific.

We still dont have a good understanding even four or five years into it exactly what the stem cells do, what their method is, Cain said. The theory is theres probably a chemical reaction where it releases chemicals in the cell that help the healing process. The stem cells arent necessarily put in there with the thought theyre going to become ligament, but theres probably a cellular chemical mechanism that helps the healing response.

And as Heaney discovered, theyre not always effective. His tear was located farther down the arm, which reduced his chances of success with stem cell therapy. Richards was a better candidate because his injury, though deemed high grade, was located within the ligament, like a slit on a rubber band.

But because Heaney was looking at likely missing most or all of 2017 even if he had surgery right away, he decided to try stem cells. The timing of the injury plays a major role in whether pitchers contemplate alternatives to surgery, with the more conservative approach often recommended if it happens early in the season.

Heaney said he doesnt regret taking that route, and would have been upset if he had undergone the ligament-replacement operation right away, only to find out he could have returned to action quicker through another means.

Im glad it worked for him, he said of Richards. It would have been really awful if it hadnt worked for either of us. Then wed both look like idiots.

Their peers are paying attention. In a major league pitching community where about a quarter of its members have undergone Tommy John surgery, interest in the effectiveness of alternative cures is high.

The Los Angeles Dodgers Brandon McCarthy was not a candidate because his ligament tore clear off the bone, but said he had heard positive reports about stem cell treatment, not so much about PRP.

The Pittsburgh Pirates Daniel Hudson, a veteran of two Tommy Johns, is encouraged as well.

Its supposed to help repair the tissue. Before, ligaments just wont repair themselves, Hudson said. It might keep a lot of guys from going under the knife.

Thats Cains hope. He regularly treats UCL tears on high school, college and minor-league players with stem cells or PRP, but realizes theres heightened pressure on major leaguers to return to the field.

If more of them can do it without visiting an operating room, it would represent a major advancement for both the players and the industry.

I think overall the biologic treatment of these injuries will certainly progress and it will be somewhat the wave of the future, Cain said. There will be certain ligaments that are damaged enough that we dont have an answer; they have to reconstruct. But I think overall, if you look 15 years down the road, I suspect well be doing a lot more non-surgical treatment than surgical treatment.

Contributing: Gabe Lacques in Bradenton, Fla.

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Parents sentenced in murder of emaciated teen with untreated diabetes – Fox News

February 27th, 2017 5:46 pm

The parents of a teenage boy who died as a result of starvation and untreated diabetes have been sentenced to life in prison without parole for 25 years.

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Alexandru Radita, 15, weighed just 35 pounds when he was found dead at his home in Calgary, Canada, after suffering years of untreated diabetes.

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His parents Emil, 60, and Rodica Radita, 54, had made it their mission to isolate Alex from anyone who could monitor his insulin treatment since his diagnosis at the age of two, a court heard.

The Raditas were found guilty of first degree murder on Friday at the end of a trial that saw harrowing testimony from witnesses, including a social worker who tried desperately to save the boy.

Paramedic Deborah Baumback gave distressing evidence regarding the condition of Alexs body when she was called to the scene of his death in 2013.

She described him as emaciated to the point where he appeared mummified, Judge Karen Horner said at the couples sentencing hearing.

His face had no visible flesh left and his left jaw had open sores so deep she could see his jawbone.

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Lancers’ Rylie Rucker refuses to be sidelined by diabetes – Quad City Times

February 27th, 2017 5:46 pm

ELDRIDGE Rylie Rucker was losing weight rapidly. She was getting out of bed and going the bathroom at least five times a night. She could not make it through a two-mile middle school cross country race without walking.

Her mother, Dena, knew something was wrong.

The symptoms resulted in a visit to Trinity Hospital in the Quad-Cities before she was transported to the University of Iowa Hospital and diagnosed with Type 1 diabetes. The date is stamped firmly in her mind: Sept. 7, 2013.

I was so emotional that first day, Rucker said. After that, it sunk in thats how life is going to be for me. You cant do anything about it so youve got to make the best of it.

It has not stopped Rucker from living an active life.

The sophomore is a starter on the Class 4A eighth-ranked North Scott girls basketball team, which opens state tournament play at 6:45 p.m. Tuesday against second-ranked Nevada at Wells Fargo Arena in Des Moines.

Type 1 diabetes is a chronic, lifelong disease where the body doesnt produce enough insulin, a hormone to convert sugar, starches and other food into energy needed for daily life.

For Rucker, it is a daily struggle. She is required to monitor her blood sugar constantly and takes six insulin shots per day on average.

We all know what she really has to go through, but a lot of people dont realize it, senior teammate Erica Loussaert said. She puts on a really tough face and comes out and plays basketball every day. Nobody knows how hard that really is for her. It is just inspiring to see.

Rucker wears a glucose monitor device, part of it clipped to her athletic shorts and a patch under her tricep, that tracks her blood sugar count every five minutes. North Scott assistant coach Devvin Rolston receives the numbers and monitors it closely during workouts and games.

If Rucker is too high or too low, she sits.

Usually during games, Im not low because of the adrenaline, she said. It really kicks into my blood sugar and pumps it up. Im usually 300 during games which is not good.

There have been occasions shes been too low. She was scratched from the starting lineup in one meeting against Bettendorf this season and played sparingly because of it.

She was a spectator at the start of last Fridays practice because of a low count.

Every day you get to see what she goes through, coach TJ Case said. The girls really respect her and know what shes battling.

They know if Rylie can fight through some of this stuff, then some of the stuff theyre dealing with isnt that bad. It is very inspirational to us.

Rucker is a key component of North Scotts success. She is the teams second-leading scorer at 8.5 points per game, shoots almost 80 percent at the foul line and is among its best defenders.

She would go through a brick wall for her teammates, Case said. She does a lot of the little things for us and cleans up things defensively. Shes always around the ball, a very smart offensive player. We lean on her a lot.

Nobody else in Ruckers immediate family has diabetes.

So when she was diagnosed, there was an initial shock. She spent more than two days in an Iowa City hospital room.

The details of that September Saturday are still fuzzy for Rucker. Her older sister, Karli, the teams leading scorer, remembers it well.

Karli was a freshman and playing volleyball at the Muscatine Invitational. Afterward, she and her grandmother met the family in Iowa City.

Everyone was emotional, Karli said. Just that initial time seeing her in that hospital bed, it hurt in your heart because you knew her life just got changed a lot. It is an every day thing, and it is not going to go away until maybe one day they can find a cure.

Rucker tries to keep her blood sugar count between 120 and 180. She doesnt recall what it was at the time of her diagnosis, but she knows it has been as high as 400 during a basketball game.

When it gets like that, I just space out and cant pay attention at all, Rucker said. My mouth gets super sticky.

Conversely, Rucker gets fatigued when the number dips below 100.

Shes very disciplined and a really healthy eater, Karli said. If her numbers are low, she has a really good mindset about it. She doesnt get down about it.

Rucker has learned to embrace the numbers game. Some days are better than others.

Ive just had a determination to not let it get the best of me, she said. It hasnt just been me having to do everything on my own.

My family has been so supportive and helped me through it. It is part of who we are now.

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Dentists at the Front Line in Diabetes Epidemic – WebMD

February 27th, 2017 5:46 pm

By Serena Gordon

HealthDay Reporter

THURSDAY, Feb. 23, 2017 (HealthDay News) -- You'd probably be surprised if your dentist said you might have type 2 diabetes. But new research finds that severe gum disease may be a sign the illness is present and undiagnosed.

The study found that nearly one in five people with severe gum disease (periodontitis) had type 2 diabetes and didn't know it. The researchers said these findings suggest that the dentist's office may be a good place for a prediabetes or type 2 diabetes screening.

"Be aware that worsened oral health -- in particular, periodontitis -- can be a sign of an underlying [condition], such as diabetes," said study author Dr. Wijnand Teeuw. He's the chief of the periodontology clinic at the Academic Center for Dentistry Amsterdam in the Netherlands.

"Early diagnosis and treatment of both periodontitis and diabetes will benefit the patient by preventing further complications," Teeuw added.

Diabetes is a worldwide epidemic. In 2010, it was estimated that 285 million adults worldwide had diabetes. By 2030, that number is expected to rise to 552 million, according to the study authors. It's suspected that as many as one-third of people who have diabetes are unaware they have the disease.

Untreated, diabetes can lead to a number of serious complications, such as vision problems, serious kidney disease, heart trouble and infections that take a long time to heal, according to the American Diabetes Association.

Periodontitis -- an infection that causes inflammation of the gums and destruction of the bones that support the teeth -- is often considered a complication of diabetes, Teeuw said.

The current study included more than 300 people from a dental clinic in Amsterdam with varying levels of periodontitis or healthy gums. Approximately 125 had mild to moderate periodontitis and almost 80 had severe periodontitis. The rest had healthy gums.

The researchers tested blood sugar levels in all of the study participants using a test called hemoglobin A1c. This test provides an average of blood sugar levels over two to three months.

In people who had never been diagnosed with diabetes, the researchers found that 50 percent of the group with severe gum troubles had prediabetes, and 18 percent had type 2 diabetes. In the mild to moderate group, 48 percent were found to have prediabetes and 10 percent learned they had type 2 diabetes.

There were even significant numbers of people in the healthy gums group that had prediabetes -- 37 percent had prediabetes and 8.5 percent had type 2 diabetes, the study revealed.

Dr. Sally Cram, a periodontist and a spokeswoman for the American Dental Association, said she sees what the study found in her practice every day.

"I see quite a few patients who don't know they have diabetes, and when they don't respond normally to periodontal therapy, I have to say, 'Go to your doctor and get tested for diabetes,'" she said.

And, on the other side, she explained that people with uncontrolled diabetes often see improvement when their gum disease is under control.

"People with diabetes aren't as able to fight inflammation and infection," Cram explained.

Diabetes specialist Dr. Joel Zonszein said frequent or slow-to-heal infections are important signs of diabetes.

"People often come in with severe infections in the skin, and I think it's probably the same for infections in the mouth. People have been living for years with high blood sugar, and even if they go to the dentist, they don't get their blood sugar checked," Zonszein said.

"The relationship between diabetes and gum infections goes two ways. When you improve one, you also improve the other," he added. But it's not clear which comes first, and this study didn't prove a cause-and-effect relationship, only an association, Zonszein noted.

But the findings do show the importance of collaboration between health care providers, according to Zonszein, who is the director of the Clinical Diabetes Center at Montefiore Medical Center in New York City.

Cram noted that basic prevention goes a long way toward preventing gum disease.

"Ninety-nine percent of dental problems and disease are preventable. Brush your teeth twice a day and floss once, and see your dentist periodically," she recommended.

Warning signs of gum disease include bleeding gums, receding gums, sensitive teeth, loose teeth, bad breath or a bad taste in the mouth.

The study was published online Feb. 22 in BMJ Open Diabetes Research & Care.

WebMD News from HealthDay

SOURCES: Wijnand Teeuw, D.D.S., M.Sc., chief, periodontology clinic, Academic Center for Dentistry Amsterdam, The Netherlands; Sally Cram, D.D.S., P.C., periodontist, Washington D.C., and spokeswoman, American Dental Association; Joel Zonszein, M.D., director, Clinical Diabetes Center, Montefiore Medical Center, New York City; Feb. 22, 2017, BMJ Open Diabetes Research & Care, online

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City of Hope Researchers Discover New Potential Cause of Type 1 Diabetes – Business Wire (press release)

February 27th, 2017 5:46 pm

DUARTE, Calif.--(BUSINESS WIRE)--An international team of researchers led by City of Hopes Bart Roep, Ph.D., the Chan Soon-Shiong Shapiro Distinguished Chair in Diabetes and professor/founding chair of the Department of Diabetes Immunology, has been able to justify an alternative theory about the cause of type 1 diabetes (T1D) through experimental work. The study results were published online today in the journal, Nature Medicine.

T1D, previously known as juvenile diabetes, affects an estimated 1.5 million Americans and is the result of the loss of insulin-producing cells in the pancreas. The prevailing belief was that the root cause of T1D was the immune system mistakenly identifying those insulin-secreting beta cells as a potential danger and, in turn, destroying them.

Now Roep, along with researchers from the Leiden University Medical Center in the Netherlands, have found a mechanism in which stressed beta cells are actually causing the immune response that leads to T1D.

Our findings show that type 1 diabetes results from a mistake of the beta cell, not a mistake of the immune system, said Roep, who is director of the Wanek Family Project for Type 1 Diabetes, which was recently created with gifts from the Wanek family and anonymous donors to support the institutions goal of curing T1D in six years. The immune system does what it is supposed to do, which is respond to distressed or unhappy tissue, as it would in infection or cancer.

In order to gain a better understanding of why the immune system attacks the bodys own source of insulin the pancreatic beta cells in the islets of Langerhans the team took some clues from cancer molecules that are targeted by the immune system after successful treatment of the cancer with immunotherapy.

One of these cancer targets is a so-called nonsense protein, resulting from a misreading of a DNA sequence that makes a nonfunctional protein. It turns out that the same type of protein error is also produced by the beta cells in T1D. Therefore, Roep and the other researchers believe it is a wrong read of the insulin gene itself that proves to be a major target of the immune system. This error product of the insulin gene is made when beta cells are stressed, Roep said.

Our study links anti-tumor immunity to islet autoimmunity, and may explain why some cancer patients develop type 1 diabetes after successful immunotherapy, he added. This is an incredible step forward in our commitment to cure this disease.

According to the paper titled, Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes, the findings further support the emerging concept that beta cells are destroyed in T1D by a mechanism comparable to classical antitumor responses where the immune system has been trained to survey dysfunctional cells in which errors have accumulated.

The results of the study give Roep new insight, he said, for his work in developing new vaccines to desensitize the immune system so that it will tolerate islets again, as well as for research into combining immunotherapy with more traditional diabetes treatments to reinvigorate islets.

Our goal is to keep beta cells happy, Roep said. So we will work on new forms of therapy to correct the autoimmune response against islets and hopefully also prevent development of type 1 diabetes during anti-cancer therapy.

The work described in the Nature Medicine paper was supported by the Dutch Diabetes Research Foundation, the DON Foundation and the JDRF.

About City of Hope

City of Hope is an independent research and treatment center for cancer, diabetes and other life-threatening diseases. Designated as one of only 47 comprehensive cancer centers, the highest recognition bestowed by the National Cancer Institute, City of Hope is also a founding member of the National Comprehensive Cancer Network, with research and treatment protocols that advance care throughout the world. City of Hope is located in Duarte, California, just northeast of Los Angeles, with communityclinics throughout Southern California. It is ranked as one of Americas Best Hospitals in cancer by U.S. News & World Report. Founded in 1913, City of Hope is a pioneer in the fields of bonemarrowtransplantation, diabetes and numerous breakthrough cancer drugs based on technology developed at the institution. For more information about City of Hope, follow us on Facebook, Twitter, YouTube or Instagram.

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THIS weight loss technique could help to CONTROL potentially deadly diabetes – Express.co.uk

February 27th, 2017 5:46 pm

Experts have found weight loss surgery can improve the health of overweight people with type 2 diabetes.

A five year study by researchers in Australia looked at people classified as overweight with a BMI between 25 and 29.9.

The experts, from Monash University in Melbourne found patients who had a gastric band fitted managed their diabetes better, improved their chances of remission and reduced the need for diabetes medication.

They also saw their weight drop by an eighth.

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Their diabetes was better controlled and they needed fewer diabetic medications to control their blood sugar levels

Dr John Wentworth

Dr John Wentworth, researcher said: "We had people who were feeling better, moving better and who were happier because of the surgery.

"Their diabetes was better controlled and they needed fewer diabetic medications to control their blood sugar levels."

He said few experienced negative side effects from the surgery and the improvement in quality of life made it cost effective.

He urged guidelines should be revised so it can be offered to those currently not eligible for the surgery.

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People should be aware signs and symptoms of diabetes are not always obvious and the condition is often diagnosed during GP check ups.

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The NHS offers the procedure to patients with potentially life-threatening obesity, including those with a BMI of over 40, or with a BMI over 35 with a serious health condition such as type 2 or high blood pressure.

Adults recently diagnosed with type 2 diabetes may also be considered for an assessment for weight loss surgery if they have a BMI of 30 to 34.9.

Type 2 diabetes occurs when the body does not produce enough insulin or the insulin produced does not work properly and can be linked to lifestyle factors such as being overweight.

Figures suggest nine in ten people with type 2 diabetes are overweight or obese and require medication to control blood glucose levels.

GETTY

However, there is a waiting list for gastric band surgery on the NHS and it can cost between 5,000 to 8,000 to have it done privately.

It costs more than 10billion a year to treat patients with type 2 diabetes.

Researchers from Monash's Centre for Obesity Research and Education randomly assigned 22 to receive gastric banding combined with medical care, and 23 who received medical care alone.

Both groups received help with lifestyle factors such as exercise and healthy eating.

It found the average weight loss of 12.2 per cent of body weight in the gastric band group compared with 1.8 per cent in the other group.

GETTY

Almost a quarter of the gastric band group showed diabetes remission at five years, compared to nine per cent of the medical care-only group.

Dr Wentworth added the results provided "reasonably strong evidence" that gastric banding, as a safe and effective weight loss operation, was an acceptable alternative for people who wanted it.

He said: "It's an important point because lap banding is criticised by some people saying it is far too drastic to be used as a diabetes treatment and that it doesn't work in the longer term.

"I think it's a matter of just looking at the best ways of managing diabetes and preventing diabetes complications.

"We're interested in making life easier for these people and reducing the risk of the main complications, mainly heart attack, kidney failure, blindness and amputation.

"Although we'd be delighted if people could lose over 10 per cent of their weight through lifestyle modification, the reality is that the vast majority of people can't manage that."

The study was published in Diabetes Care.

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