StemCell Therapy

From Nobel Prizewinning author Jos Saramago, a magnificent, mesmerizing parable of loss

A city is hit by an epidemic of "white blindness" that spares no one. Authorities confine the blind to an empty mental hospital, but there the criminal element holds everyone captive, stealing food rations and assaulting women. There is one eyewitness to this nightmare who guides her c

A city is hit by an epidemic of "white blindness" that spares no one. Authorities confine the blind to an empty mental hospital, but there the criminal element holds everyone captive, stealing food rations and assaulting women. There is one eyewitness to this nightmare who guides her chargesamong them a boy with no mother, a girl with dark glasses, a dog of tearsthrough the barren streets, and their procession becomes as uncanny as the surroundings are harrowing. As Blindness reclaims the age-old story of a plague, it evokes the vivid and trembling horrors of the twentieth century, leaving readers with a powerful vision of the human spirit that's bound both by weakness and exhilarating strength.

Read more here:
Blindness (Blindness, #1) by Jos Saramago Reviews ...

Color blindness, or color vision deficiency, is the inability or decreased ability to see color, or perceive color differences, under normal lighting conditions. Color blindness affects a significant percentage of the population.[1] There is no actual blindness but there is a deficiency of color vision. The most usual cause is a fault in the development of one or more sets of retinal cones that perceive color in light and transmit that information to the optic nerve. This type of color blindness is usually a sex-linked condition. The genes that produce photopigments are carried on the X chromosome; if some of these genes are missing or damaged, color blindness will be expressed in males with a higher probability than in females because males only have one X chromosome (in females, a functional gene on only one of the two X chromosomes is sufficient to yield the needed photopigments).[2]

Color blindness can also be produced by physical or chemical damage to the eye, the optic nerve, or parts of the brain. For example, people with achromatopsia suffer from a completely different disorder, but are nevertheless unable to see colors.

The first scientific paper on this subject, Extraordinary facts relating to the vision of colours, was published by the English chemist John Dalton in 1798[3] after the realization of his own color blindness. Because of Dalton's work, the general condition has been called daltonism, although in English this term is now used only for deuteranopia.

Color blindness is usually classified as a mild disability, however there are occasional circumstances where it can give an advantage. Some studies conclude that color blind people are better at penetrating certain color camouflages. Such findings may give an evolutionary reason for the high prevalence of redgreen color blindness.[4] There is also a study suggesting that people with some types of color blindness can distinguish colors that people with normal color vision are not able to distinguish.[5]

Color blindness affects a large number of individuals, with protanopia and deuteranopia being the most common types.[6] In individuals with Northern European ancestry, as many as 8 percent of men and 0.4 percent of women experience congenital colour deficiency.[7] The typical human retina contains two kinds of light cells: the rod cells (active in low light) and the cone cells (active in normal daylight). Normally, there are three kinds of cone cells, each containing a different pigment, which are activated when the pigments absorb light. The spectral sensitivities of the cones differ; one is most sensitive to short wavelengths, one to medium wavelengths, and the third to medium-to-long wavelengths within the visible spectrum, with their peak sensitivities in the blue, green, and yellow-green regions of the spectrum, respectively. The absorption spectra of the three systems overlap, and combine to cover the visible spectrum. These receptors are often called S cones, M cones, and L cones, for short, medium, and long wavelength; but they are also often referred to as blue cones, green cones, and red cones, respectively.[8]

Although these receptors are often referred to as "blue, green, and red" receptors, this terminology is inaccurate. The receptors are each responsive to a wide range of wavelengths. For example, the long wavelength, "red", receptor has its peak sensitivity in the yellow-green, some way from the red end (longest wavelength) of the visible spectrum. The sensitivity of normal color vision actually depends on the overlap between the absorption ranges of the three systems: different colors are recognized when the different types of cone are stimulated to different degrees. Red light, for example, stimulates the long wavelength cones much more than either of the others, and reducing the wavelength causes the other two cone systems to be increasingly stimulated, causing a gradual change in hue.

Many of the genes involved in color vision are on the X chromosome, making color blindness much more common in males than in females because males only have one X chromosome, while females have two. Because this is an X-linked trait, an estimated 23% of women have a 4th color cone[9] and can be considered tetrachromats, although it is not clear that this provides an advantage in color discrimination.

Color vision deficiencies can be classified as acquired or inherited.

Based on clinical appearance, color blindness may be described as total or partial. Total color blindness is much less common than partial color blindness.[17] There are two major types of color blindness: those who have difficulty distinguishing between red and green, and who have difficulty distinguishing between blue and yellow.[18][19]

Immunofluorescent imaging is a way to determine red-green color coding. Conventional color coding is difficult for individuals with red-green color blindness (protanopia or deuteranopia) to discriminate. Replacing red with magenta (top[where?]) or green with turquoise (bottom[where?]) improves visibility for such individuals.[20][not in citation given]

More:
Color blindness - Wikipedia, the free encyclopedia

"Bioscience" redirects here. For the scientific journal, see BioScience. For life sciences generally, see life science.

Biotechnology is the use of living systems and organisms to develop or make products, or "any technological application that uses biological systems, living organisms or derivatives thereof, to make or modify products or processes for specific use" (UN Convention on Biological Diversity, Art. 2).[1] Depending on the tools and applications, it often overlaps with the (related) fields of bioengineering, biomedical engineering, etc.

For thousands of years, humankind has used biotechnology in agriculture, food production, and medicine.[2] The term is largely believed to have been coined in 1919 by Hungarian engineer Kroly Ereky. In the late 20th and early 21st century, biotechnology has expanded to include new and diverse sciences such as genomics, recombinant gene techniques, applied immunology, and development of pharmaceutical therapies and diagnostic tests.[2]

The wide concept of "biotech" or "biotechnology" encompasses a wide range of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Modern usage also includes genetic engineering as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as the application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materials and organisms such as pharmaceuticals, crops, and livestock.[3] As per European Federation of Biotechnology, Biotechnology is the integration of natural science and organisms, cells, parts thereof, and molecular analogues for products and services.[4] Biotechnology also writes on the pure biological sciences (animal cell culture, biochemistry, cell biology, embryology, genetics, microbiology, and molecular biology). In many instances, it is also dependent on knowledge and methods from outside the sphere of biology including:

Conversely, modern biological sciences (including even concepts such as molecular ecology) are intimately entwined and heavily dependent on the methods developed through biotechnology and what is commonly thought of as the life sciences industry. Biotechnology is the research and development in the laboratory using bioinformatics for exploration, extraction, exploitation and production from any living organisms and any source of biomass by means of biochemical engineering where high value-added products could be planned (reproduced by biosynthesis, for example), forecasted, formulated, developed, manufactured and marketed for the purpose of sustainable operations (for the return from bottomless initial investment on R & D) and gaining durable patents rights (for exclusives rights for sales, and prior to this to receive national and international approval from the results on animal experiment and human experiment, especially on the pharmaceutical branch of biotechnology to prevent any undetected side-effects or safety concerns by using the products).[5][6][7]

By contrast, bioengineering is generally thought of as a related field that more heavily emphasizes higher systems approaches (not necessarily the altering or using of biological materials directly) for interfacing with and utilizing living things. Bioengineering is the application of the principles of engineering and natural sciences to tissues, cells and molecules. This can be considered as the use of knowledge from working with and manipulating biology to achieve a result that can improve functions in plants and animals.[8] Relatedly, biomedical engineering is an overlapping field that often draws upon and applies biotechnology (by various definitions), especially in certain sub-fields of biomedical and/or chemical engineering such as tissue engineering, biopharmaceutical engineering, and genetic engineering.

Although not normally what first comes to mind, many forms of human-derived agriculture clearly fit the broad definition of "'utilizing a biotechnological system to make products". Indeed, the cultivation of plants may be viewed as the earliest biotechnological enterprise.

Agriculture has been theorized to have become the dominant way of producing food since the Neolithic Revolution. Through early biotechnology, the earliest farmers selected and bred the best suited crops, having the highest yields, to produce enough food to support a growing population. As crops and fields became increasingly large and difficult to maintain, it was discovered that specific organisms and their by-products could effectively fertilize, restore nitrogen, and control pests. Throughout the history of agriculture, farmers have inadvertently altered the genetics of their crops through introducing them to new environments and breeding them with other plants one of the first forms of biotechnology.

These processes also were included in early fermentation of beer.[9] These processes were introduced in early Mesopotamia, Egypt, China and India, and still use the same basic biological methods. In brewing, malted grains (containing enzymes) convert starch from grains into sugar and then adding specific yeasts to produce beer. In this process, carbohydrates in the grains were broken down into alcohols such as ethanol. Later other cultures produced the process of lactic acid fermentation which allowed the fermentation and preservation of other forms of food, such as soy sauce. Fermentation was also used in this time period to produce leavened bread. Although the process of fermentation was not fully understood until Louis Pasteur's work in 1857, it is still the first use of biotechnology to convert a food source into another form.

Before the time of Charles Darwin's work and life, animal and plant scientists had already used selective breeding. Darwin added to that body of work with his scientific observations about the ability of science to change species. These accounts contributed to Darwin's theory of natural selection.[10]

Read the original:
Biotechnology - Wikipedia, the free encyclopedia

I like the fact that I get notified when someone wants my resume, and that you only give my personal information to real employers with real jobs.

Just a short note in praise of your service which has allowed our start-up company to surface and hire almost every position we reviewed from Medzilla.

One of my former employers saw my CV on Medzilla and contacted me. I am now re-employed by that employer.

I am seriously impressed with the level of involvement you have in this website and my job search! Thank you for your attention and efforts.

We did hire from your website, which compared to a recruiter fee, saved a tremendous amount of money! Thanks for your help.

I've had 3 calls w/in a 48 hour period of posting my resume. I appreciate the thorough nature of MEDZILLA's follow up with emails each time my resume has been sent and the respect for privacy your company has shown.

We eventually hired a young man that we found through MedZilla and he has been a real asset to our corporation. My only regret is that we aren't a larger company that could use your services more often!

See the original post:
Medzilla;Biotech Jobs, Pharmaceutical Jobs, Pharmaceutical ...

What is arthritis?

The word arthritis actually means joint inflammation, but the term has acquired a wider meaning. In public health, arthritis is used as a shorthand term for arthritis and other rheumatic conditionsa label for the more than 100 rheumatic diseases and conditions that affect joints, the tissues which surround joints and other connective tissue. The pattern, severity, and location of symptoms can vary depending on the specific form of the disease. Typically, rheumatic conditions are characterized by pain and stiffness in and around one or more joints. The symptoms can develop gradually or suddenly. Certain rheumatic conditions can also involve the immune system and various internal organs of the body.

The most common forms of arthritis are discussed in theArthritis Types section. For a more detailed discussion of each of these conditions follow the links provided for you. The Resources section of our website can guide you to further information on many topics related to rheumatic diseases.

Top of Page

Who is at risk for arthritis?

Certain factors are associated with a greater risk of arthritis. Some of these risk factors are modifiable while others are not.

Non-modifiable risk factors

Modifiable risk factors

Top of Page

What causes arthritis?

See the article here:
CDC - Arthritis - Basics - FAQs

Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that primarily affects joints.[1] It may result in deformed and painful joints, which can lead to loss of function. The disease may also have signs and symptoms in organs other than joints.

The cause of rheumatoid arthritis is not completely understood. The process involves inflammation and fibrosis of the capsule around the joints. It also affects the underlying bone and cartilage.[1] RA can produce diffuse inflammation in the lungs, the membrane around the heart, the membranes of the lung, and whites of the eye. It can also produce nodular lesions, most common within the skin. It is a clinical diagnosis made mostly on the basis of symptoms and physical examination. X-rays, laboratory testing, and synovial fluid analysis might help support a diagnosis or exclude other diseases with similar symptoms.[2]

Treatments include both medication and non-pharmacological measures - the goal being to control joint inflammation and prevent joint damage and disability. Non-pharmacological treatment includes physical therapy, splints and braces, occupational therapy and dietary changes but these do not stop the progression of joint destruction. Painkillers and anti-inflammatory drugs, including steroids, suppress symptoms, but do not stop the progression either. Disease-modifying antirheumatic drugs (DMARDs) may slow or halt the progress of the disease.[2] Biological DMARDS like anti-TNF agents are effective but usually avoided in persons with active disease or hypersensitivity to these agents.[3] They have been shown to decrease the number of tender or swollen joints and the pain and disability due to the disease but there is little data about side effects.[4]Alternative medicine is not supported by evidence.[5][6][7]

RA affects between 0.5 and 1% of adults in the developed world with between 5 and 50 per 100,000 people newly developing the condition each year.[8] Onset is most frequent during middle age, but people of any age can be affected.[9] In 2013 it resulted in 38,000 deaths up from 28,000 deaths in 1990.[10] The name is based on the term "rheumatic fever", an illness which includes joint pain and is derived from the Greek word -rheuma (nom.), -rheumatos (gen.) ("flow, current"). The suffix -oid ("resembling") gives the translation as joint inflammation that resembles rheumatic fever. The first recognized description of RA was made in 1800 by Dr. Augustin Jacob Landr-Beauvais (17721840) of Paris.[11]

RA primarily affects joints, however it also affects other organs in more than 1525% of individuals.[12]

Arthritis of joints involves inflammation of the synovial membrane. Joints become swollen, tender and warm, and stiffness limits their movement. With time, multiple joints are affected (it is a polyarthritis). Most commonly involved are the small joints of the hands, feet and cervical spine, but larger joints like the shoulder and knee can also be involved.[13]:1089 Synovitis can lead to tethering of tissue with loss of movement and erosion of the joint surface causing deformity and loss of function.[2]

RA typically manifests with signs of inflammation, with the affected joints being swollen, warm, painful and stiff, particularly early in the morning on waking or following prolonged inactivity. Increased stiffness early in the morning is often a prominent feature of the disease and typically lasts for more than an hour. Gentle movements may relieve symptoms in early stages of the disease. These signs help distinguish rheumatoid from non-inflammatory problems of the joints, often referred to as osteoarthritis or "wear-and-tear" arthritis. In arthritis of non-inflammatory causes, signs of inflammation and early morning stiffness are less prominent with stiffness typically less than one hour, and movements induce pain caused by mechanical arthritis.[14] The pain associated with RA is induced at the site of inflammation and classified as nociceptive as opposed to neuropathic.[15] The joints are often affected in a fairly symmetrical fashion, although this is not specific, and the initial presentation may be asymmetrical.[13]:1089

As the pathology progresses the inflammatory activity leads to tendon tethering and erosion and destruction of the joint surface, which impairs range of movement and leads to deformity. The fingers may suffer from almost any deformity depending on which joints are most involved. Specific deformities, which also occur in osteoarthritis, include ulnar deviation, boutonniere deformity, swan neck deformity and "Z-thumb." "Z-thumb" or "Z-deformity" consists of hyperextension of the interphalangeal joint, fixed flexion and subluxation of the metacarpophalangeal joint and gives a "Z" appearance to the thumb.[13]:1089 The hammer toe deformity may be seen. In the worst case, joints are known as arthritis mutilans due to the mutilating nature of the deformities.[1]

The rheumatoid nodule, which is sometimes cutaneous, is the feature most characteristic of RA. It is a type of inflammatory reaction known to pathologists as a "necrotizing granuloma". The initial pathologic process in nodule formation is unknown but may be essentially the same as the synovitis, since similar structural features occur in both. The nodule has a central area of fibrinoid necrosis that may be fissured and which corresponds to the fibrin-rich necrotic material found in and around an affected synovial space. Surrounding the necrosis is a layer of palisading macrophages and fibroblasts, corresponding to the intimal layer in synovium and a cuff of connective tissue containing clusters of lymphocytes and plasma cells, corresponding to the subintimal zone in synovitis. The typical rheumatoid nodule may be a few millimetres to a few centimetres in diameter and is usually found over bony prominences, such as the elbow, the heel, the knuckles, or other areas that sustain repeated mechanical stress. Nodules are associated with a positive RF (rheumatoid factor) titer and severe erosive arthritis. Rarely, these can occur in internal organs or at diverse sites on the body.[citation needed].

Several forms of vasculitis occur in RA. A benign form occurs as microinfarcts around the nailfolds. More severe forms include livedo reticularis, which is a network (reticulum) of erythematous to purplish discoloration of the skin caused by the presence of an obliterative cutaneous capillaropathy.[citation needed].

See original here:
Rheumatoid arthritis - Wikipedia, the free encyclopedia

July 2014

Many people start to feel pain and stiffness in their bodies over time. Sometimes their hands or knees or shoulders get sore and are hard to move and may become swollen. These people may have arthritis (ar-THRY-tis). Arthritis may be caused by inflammation (in-flah-MAY-shun) of the tissue lining the joints. Some signs of inflammation include redness, heat, pain, and swelling. These problems are telling you that something is wrong.

Joints are places where two bones meet, such as your elbow or knee. Over time, in some types of arthritis but not in all, the joints involved can become severely damaged.

There are different types of arthritis. In some diseases in which arthritis occurs, other organs, such as your eyes, your chest, or your skin, can also be affected. Some people may worry that arthritis means they wont be able to work or take care of their children and their family. Others think that you just have to accept things like arthritis.

Its true that arthritis can be painful. But there are things you can do to feel better. This publication tells you some facts about arthritis and gives you some ideas about what to do so you can keep doing many of the things you enjoy.

There are several types of arthritis. The two most common ones are osteoarthritis (AH-stee-oh-ar-THRY-tis) and rheumatoid (ROO-mah-toyd) arthritis.

Osteoarthritis is the most common form of arthritis. This condition usually comes with age and most often affects the fingers, knees, and hips. Sometimes osteoarthritis follows an injury to a joint. For example, a young person might hurt his knee badly playing soccer. Or someone might fall or be injured in a car accident. Then, years after the individuals knee has apparently healed, he might get arthritis in his knee joint.

Rheumatoid arthritis happens when the bodys own defense system doesnt work properly. It affects joints and bones (often of the hands and feet), and may also affect internal organs and systems. You may feel sick or tired, and you may have a fever.

Another common type of arthritis, gout, is caused by crystals that build up in the joints. It usually affects the big toe, but many other joints may be affected.

Arthritis is seen with many other conditions. These include:

Originally posted here:
Living with Arthritis

This article is about the medical therapy. For the cell type, see Stem cell.

Stem cell therapy is the use of stem cells to treat or prevent a disease or condition.

Bone marrow transplant is the most widely used stem cell therapy, but some therapies derived from umbilical cord blood are also in use. Research is underway to develop various sources for stem cells, and to apply stem cell treatments for neurodegenerative diseases and conditions, diabetes, heart disease, and other conditions.

With the ability of scientists to isolate and culture embryonic stem cells, and with scientists' growing ability to create stem cells using somatic cell nuclear transfer and techniques to create induced pluripotent stem cells, controversy has crept in, both related to abortion politics and to human cloning. Additionally, efforts to market treatments based on transplant of stored umbilical cord blood have proven controversial.

For over 30 years, bone-marrow have been used to treat cancer patients with conditions such as leukaemia and lymphoma; this is the only form of stem cell therapy that is widely practiced.[1][2][3] During chemotherapy, most growing cells are killed by the cytotoxic agents. These agents, however, cannot discriminate between the leukaemia or neoplastic cells, and the hematopoietic stem cells within the bone marrow. It is this side effect of conventional chemotherapy strategies that the stem cell transplant attempts to reverse; a donor's healthy bone marrow reintroduces functional stem cells to replace the cells lost in the host's body during treatment. The transplanted cells also generate an immune response that helps to kill off the cancer cells; this process can go too far, however, leading to graft vs host disease, the most serious side effect of this treatment.[4]

Another stem cell therapy called Prochymal, was conditionally approved in Canada in 2012 for the management of acute graft-vs-host disease in children who are unresponsive to steroids.[5] It is an allogenic stem therapy based on mesenchymal stem cells (MSCs) derived from the bone marrow of adult donors. MSCs are purified from the marrow, cultured and packaged, with up to 10,000 doses derived from a single donor. The doses are stored frozen until needed.[6]

The FDA has approved five hematopoietic stem cell products derived from umbilical cord blood, for the treatment of blood and immunological diseases.[7]

In 2014, the European Medicines Agency recommended approval of Holoclar, a treatment involving stem cells, for use in the European Union. Holoclar is used for people with severe limbal stem cell deficiency due to burns in the eye.[8]

Research has been conducted to learn whether stem cells may be used to treat brain degeneration, such as in Parkinson's, Amyotrophic lateral sclerosis, and Alzheimer's disease.[9][10][11]

Healthy adult brains contain neural stem cells which divide to maintain general stem cell numbers, or become progenitor cells. In healthy adult animals, progenitor cells migrate within the brain and function primarily to maintain neuron populations for olfaction (the sense of smell). Pharmacological activation of endogenous neural stem cells has been reported to induce neuroprotection and behavioral recovery in adult rat models of neurological disorder.[12][13][14]

Read more here:
Stem cell therapy - Wikipedia, the free encyclopedia

Welcome to Regenexx Stem Cell Therapy for Arthritis & InjuriesChris Centeno2015-05-11T15:25:31+00:00

The Regenexx Procedures are the nations most advanced non-surgical stem cell and blood platelet treatments for common injuries and degenerative joint conditions, such as osteoarthritis and avascular necrosis. These stem cell procedures utilize a patients own stem cells or blood platelets to help heal damaged tissues, tendons, ligaments, cartilage, spinal disc, or bone.

The list below represents the most commonly treated conditions using Regenexx stem cell or platelet procedures. It is not a complete list, so please contact us or complete the Regenexx Candidate Form if you have questions about whether you or your condition can be treated with these non-surgical procedures. The type of procedure used (stem cell or blood platelet) to treat these conditions is largely dependent upon the severity of the injury or condition.

0

AND COUNTINGMORE THAN 16,000 REGENEXX PROCEDURES HAVE BEEN PERFORMED AS OF FEBRUARY 2015 (SINCE 2005)

0%

THE PUBLISHED RESEARCH ON REGENEXX PROCEDURES ACCOUNTS FOR APPROX. 30% OF THE WORLDS ORTHOPEDIC STEM CELL LITERATURE (cumulative n of patients published and treated with bone marrow stem cells)

Regenexx and the Centeno-Schultz Clinic is theoriginalstem cell based musculoskeletal practice in the United States, with more stem cell orthopedics experience than any other clinic. Regenexx and the Regenexx Network are physician leaders in stem cell treatments for osteoarthritis, joint injuries and spine conditions, in terms of research presentations, publications, and academic achievements.

As our Regenexx Physician Network grows, so does the nationwide awareness of our next-generation regenerative procedures. This video selection is comprised of recent local news stories, media coverage and hit television show appearances, featuring Regenexx doctors and patients from around the network, sharing their stories. For more Regenexx videos, please visit our videos page or YouTube Channel.

The rest is here:
Stem Cell Therapy for Arthritis and Injuries | Regenexx

The endocrine system is made up of glands throughout the body that regulate the function, growth and development of tissues and organs by secreting hormones directly into the bloodstream. Endocrine disorders develop when a gland malfunctions and secretes either too much or too little of a hormone due to illness, surgical removal or natural causes.

The Department of Endocrinology, Diabetes & Metabolism at Lahey is dedicated to delivering high-quality health care to patients with the full spectrum of endocrine and metabolic conditions. These include diabetes and disorders of the pancreas; weight problems; thyroid, parathyroid, adrenal and pituitary diseases; calcium and metabolic bone disorders including osteoporosis; as well as male and female hormone imbalance including sexual dysfunction.

Our physicians and programs have been recognized in Boston magazine and U.S. News & World Report. The American Diabetes Association (ADA) has awarded the prestigious Education Recognition Certificate to Lahey's diabetes and self-management education program since 2002. Working together with physicians in Lahey's Cardiovascular Medicine Department, we are also breaking new ground in the study of "metabolic syndrome," a condition characterized by high blood pressure, an abnormal cholesterol profile and obesity.

To ensure you receive the highest level of patient care, we provide ongoing continuing education to our staff and training of fellows, residents and medical students. Through research and participation in clinical trials, we strive to contribute to an expanding understanding of endocrinology and the ways in which it relates to your health and quality of life.

See the rest here:
Lahey Hospital & Medical Center | Endocrinology

Click Here for Full Article

1 Stem Cell Treatments can help you today! Stem cells can actually help with a variety of conditions like Cerebral Palsy, ALS, Parkinsons, Stroke, TBI and more! read more.

2 Bone Marrow Stem Cells can be used as a safe & effective treatment for degenerative diseases. Dr. Steenblock has successfully performed/consulted on over 3,000 bone marrow stem cell therapy cases. read more

3Stemgevity was developed by physician Dr. David Steenblock to help mobilize your bodys own stem cells. Stemgevity is an all natural supplement that can help you start healing todayread more

4 In this revolutionizing book, both Dr. Steenblock & Dr. Payne describe the benefits of healthy umbilical cord stem cells and their ability to treat conditions like Cerebral Palsy.read more

The use of fat stem cells is not without risk, something brought into sharp focus late last year (2012) when stories surfaced in the media concerning a lady in Los Angeles who had a cosmetic procedure in which mesenchymal stem cells isolated from her own harvested fat were injected around her eyes along with a FDA approved dermal filler used to reduce wrinkles. The dermal filler contained calcium hydroxylapatite Read More

To hear critics of complementary alternative medicine (CAM) tell it, wholistic doctors such as myself are having a pervasive and insidious influence not only among medical consumers (aka the public) but weve managed to thoroughly infiltrate academia and hospitals and as a result are poised to catapult medicine back into the prescientific Middle Ages. If you compare the language and reasoning of many modern day quackbusters and so-called skeptics alongside newspaper articles from the 1950s McCarthy era Read More

DISCLAIMER: The use of stem cells or stem cell rich tissues as well as the mobilization of stem cells by any means, e.g., pharmaceutical, mechanical or herbal-nutrient is not FDA approved to combat aging or to prevent, treat, cure or mitigate any disease or medical condition mentioned, cited or described in any document or article on this website. This website and the information featured, showcased or otherwise appearing on it is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. Those who visit this web site should not rely on information provided on it for their own health problems. Any questions regarding your own health should be addressed to your physician or other duly licensed healthcare provider. This website makes no guarantees, warranties or express or implied representations whatsoever with regard to the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. This website and its owners and operators do not assume any risk whatsoever for your use of this website or the information posted herein. Health-related information and opinions change frequently and therefore information contained on this Website may be outdated, incomplete or incorrect. All statements made about products, drugs and such on this website have not been evaluated by the Food and Drug Administration (FDA). In addition, any testimonials appearing on this website are based on the experiences of a few people and you are not likely to have similar results. Use of this Website does not create an expressed or implied professional relationship.

Excerpt from:
Stem Cells Adult Stem Cells & Stem Cell Treatments ...

In dogs, cats, ferrets, and pet birds, reproductive physiology is under the control of the hypothalamicpituitary-gonadal (HPG) axis. Many hormones are responsible for estrus and reproduction, the most significant being luteinizing hormone (LH), follicle stimulating hormone (FSH), and gonadotropin-releasing hormone (GnRH). Short-lived GnRH is released in a pulsatile fashion from the hypothalamus and acts on the pars distalis of the pituitary gland to stimulate the synthesis and release of the gonadotropins, FSH and LH (Figure 1). Secretion of these gonadotropins into the circulation lead to changes gonadal hormone production and reproductive function. Chemical modification of the native short-acting GnRH molecule has led to development of long-acting, potent GnRH agonists, which have been used as a medical means of management for a number of reproductive issues and diseases of companion animals (1-3). GnRH agonists may either stimulate estrus or effectively sterilize the patient, depending on the duration of action and the dosage applied. These agents work by initially stimulating gonadotrophin secretion, followed shortly thereafter with desensitization of the GnRH receptor to the GnRH agonist (Figure 2). This results in a temporary but long-term, fully-reversible down-regulation of gonadotrophin secretion, leading to suppression of reproduction function in both male and female animals (4). In recent years, effective low-dose, slow-release implants containing potent GnRH agonists have been released for use in veterinary medicine, especially in Europe and Australia. In companion animals, the deslorelin implant (Suprelorin, Virbac) is the most commonly GnRH agonist used in small animals (5). Deslorelin implants work by lowering pituitary gonadotrophin section. This is not a permanent change but depending on the deslorelin dose, can last up to many months. The implant does not have to be removed, but subsequent doses are needed to sustain the effect.

Unfortunately, GnRH agonist availability is limited in the United States. Although there are GnRH agonists available that are approved for the treatment of human diseases, such as prostate cancer, they are costly and not financially feasible for a pet owner to consider. To date, deslorelin acetate (Suprelorin, Virbac Animal Health, Fort Worth, TX, USA) is the only GnRH agonist that is currently available in the United States but only for the treatment of adrenal disease in ferrets (6). However, it is not legal to use Suporelin in non-ferret species in the United States and extra-label use is explicitly prohibited.

The aim of this blog is to review the applications and treatments of the deslorelin (GnRH agonist) currently used in companion animal medicine.

Deslorelin Use in Intact Male Dogs In male dogs treated with deslorelin, this GnRH agonist leads to decreased gonadotropins secretion and resultant lowered plasma testosterone concentrations, decreased testicular volume, and azoospermia (1-3,7-9). However, the response to this GnRH agonist can be very variable from one dog to another, and the duration of inhibition of testosterone secretion depends both on the concentration of the deslorelin implant and the size of the dog.

Many studies have confirmed that use of GnRH agonists for reversible chemical sterilization in male dogs is both safe and well-tolerated (7-9). Furthermore, repeated implantation can be used to maintain circulating testosterone at low concentrations. If the deslorelin implants are stopped, the treated dogs will regain normal serum testosterone levels within a few weeks, with full recovery of seminal quality once the GnRH implant has lost its efficacy (10,11).

In addition to contraception, GnRH agonists have also been used to reduce the size of the prostate gland, an effect that may be useful in dogs with benign prostatic hyperplasia (12-14).

Deslorelin in Intact Male Cats As in dogs, GnRH agonists are gaining increased importance in feline reproductive medicine (2,3,15). In intact male cats, deslorelin implants induce chemical sterilization, as in dogs. In these cats, testosterone concentrations decline rapidly to undetectable values by 3 weeks after implantation and remain low for weeks in the majority of the tomcats treated. As the circulating testosterone falls, the testicular volume decreases and penile spines disappear.

However, high individual variability has been reported, with the duration of efficacy varying between 6 and 24 months (15-17). Similar to dogs, it is possible to use repeated implantation of deslorelin to sustain the drugs effect.

Deslorelin in Intact Bitches Although deslorelin implants are only approved for male dogs in Europe (and again, not at all in the USA), studies have been performed in the bitch to investigate its use either as a contraceptive or a method of estrus induction (1-3,18-20).

The first step in the mechanism of action of all GnRH agonists is the stimulation in FSH and LH secretion (so-called "flare-up effect") (4). This followed within a few days by a profound hypogonadal effect (i.e., decrease in FSH and LH levels), which is achieved through receptor down-regulation by internalization of receptors. Generally this induced and reversible hypogonadism is the therapeutic goal, as noted above for the male dogs and cats (1-3).

Here is the original post:
Insights into Veterinary Endocrinology

Download Cord Blood Stem Cells and Regenerative Medicine PDF
Download PDF Here: http://bit.ly/1GSodzZ.

By: Monet Siler

View post:
Download Cord Blood Stem Cells and Regenerative Medicine PDF - Video

What #39;s the Difference Between PRP and Stem Cell Therapy? | Doctors Talk
Doctors Talk is an exclusive program by CVR Health TV in which a specialist will discuss about different health problems and suggest remedies. Watch CVR Health, the 24/7 health channel with...

By: CVR Health TV

Read more here:
What's the Difference Between PRP and Stem Cell Therapy? | Doctors Talk - Video

Download Stem Cells and Cancer Stem Cells, Volume 6 PDF
Download PDF Here: http://bit.ly/1EQDEZ4.

By: Eva Blythe

Read the original post:
Download Stem Cells and Cancer Stem Cells, Volume 6 PDF - Video

Embryonic and induced pluripotent stem cells Part 2
In this video we discuss embryonic and induced pluripotent stem cells. Topics discussed include the origins of cell specialization, the master transcription regulators of pluripotency and the...

By: Ben Garside

Here is the original post:
Embryonic and induced pluripotent stem cells Part 2 - Video

Treatment of Rotator Cuff tendinitis with Platelet Rich Plasma and Stem cells
Siddharth Tambar MD of Chicago Arthritis discusses treatment of rotator cuff tendinitis with the Regenexx platelet rich plasma and stem cell protocols.

By: Chicago Arthritis

Read more:
Treatment of Rotator Cuff tendinitis with Platelet Rich Plasma and Stem cells - Video

Autism in our home
This is a video about what autism is like in our home. We are trying to raise money for Cohen and Max to have Stem Cell Therapy. Please visit http://www.gofundme.com/cohenandmax to donate....

By: Jake Smith

Go here to read the rest:
Autism in our home - Video

Autologous Adipose Tissue Derived Stromal Vascular Fraction Cells Application In Patients
The U.S. Stem Cell Clinic is founded on the principle belief that the quality of life for our patients can be improved through stem cell therapy. We are dedicated to providing safe and effective...

By: U.S. Stem Cell Clinic

View original post here:
Autologous Adipose Tissue Derived Stromal Vascular Fraction Cells Application In Patients - Video

Platelet Rich Plasma Injections For Chronic Pain Relief May Help You Avoid Sugery
http://ColumbiaPain.org (541) 716-6469 Dr David Russo with Columbia Pain Management talks about the use of platelet rich plasma injections for chronic pain relief. Stem Cell Therapy can...

By: Trey Rigert

View original post here:
Platelet Rich Plasma Injections For Chronic Pain Relief May Help You Avoid Sugery - Video