Cloning advancement: Scientists create embryonic stem cells from adult skin
The advancement could one day fight a range of conditions including Alzheimer #39;s and Parkinson #39;s. CBS News medical consultant Dr. David Agus discusses the bre...
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Cloning advancement: Scientists create embryonic stem cells from adult skin - Video
Lawrence LeBlond for redOrbit.com Your Universe Online
Invasive bladder cancer (IBC), a malignant disease that currently affects more than 375,000 people worldwide, has been found to be caused by a single type of cell in the lining of the bladder, according to researchers with the Stanford University School of Medicine.
The researchers say this is the first study to pinpoint the normal cell type that can give rise to IBC. It is also the first study to show that most bladder cancers and their precancerous lesions arise from just one cell, which could also explain why many bladder cancers recur after therapy.
Weve learned that, at an intermediate stage during cancer progression, a single cancer stem cell and its progeny can quickly and completely replace the entire bladder lining, Philip Beachy, PhD, professor of biochemistry and of developmental biology, said in a statement. All of these cells have already taken several steps along the path to becoming an aggressive tumor. Thus, even when invasive carcinomas are successfully removed through surgery, this corrupted lining remains in place and has a high probability of progression.
Beachy and colleagues found that while cancer stem cells and the precancerous lesions they form express an important signaling protein known as sonic hedgehog, the cells of subsequent invasive cancers invariably do not a critical switch that appears vital for invasion and metastasis. This switch may explain certain confusing aspects of previous studies on the cellular origins of bladder cancer in humans. It also pinpoints a possible weak link in cancer progression that could be targeted by therapies.
This could be a game changer in terms of therapeutic and diagnostic approaches, said Michael Hsieh, MD, PhD, assistant professor of urology and a co-author of the study. Until now, its not been clear whether bladder cancers arise as the result of cancerous mutations in many cells in the bladder lining as the result of ongoing exposure to toxins excreted in the urine, or if its due instead to a defect in one cell or cell type. If we can better understand how bladder cancers begin and progress, we may be able to target the cancer stem cell, or to find molecular markers to enable earlier diagnosis and disease monitoring.
Bladder cancer is the fourth most common cancer in men and the ninth in women. There are two main types of bladder cancer: one that invades the muscle around the bladder and then metastasizes to other organs, and another that remains confined to the bladder lining. Unlike noninvasive cancers, most invasive bladder cancers are untreatable. Those that can be treated are expensive and difficult to cure, and with a high likelihood of recurrences, ongoing monitoring is required.
To determine what genes or cell types are at play in the formation of bladder cancer, the study team used a mouse model that closely mimicked what happens in humans. Usually, researchers rely on prior knowledge or guesses as to what genes are involved and often genetically alter cell types in animals to induce overexpression of a gene known to be involved in tumorigenesis or to block the expression of a gene that inhibits cancer development.
LINK TO SMOKING
Previous work by Beachy and his colleagues suggested that basal cells play a role in bladder cancer. However, the new study offered an unbiased approach.
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Single Cell Type Found To Cause Most Invasive Bladder Cancers: Study
Madison #39;s Before After Stem Cell Therapy
Had step cell therapy procedure on 4/14/14 and we were seeing noticeable results only 4 short days later.
By: Jaie Locke
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Madison's Before & After Stem Cell Therapy - Video
Tuesday, April 22 11:57:06
Orbsen Therapeutics, a spin-out from NUI Galway's Regenerative Medicine Institute (REMEDI), is to partner with the University of Birmingham in a E6 million EU FP7 funded MERLIN project to fight liver disease.
The EU FP7-funded project known by the acronym "MERLIN" (MEsynchymal stem cells to Reduce Liver INflammation) is led by Professor Phil Newsome, Clinical Director of the Birmingham University Stem Cell Centre. MERLIN will advance Orbsen's proprietary cell therapy to a Phase 2a clinical trial in patients with inflammatory liver disease. This MERLIN project will evaluate the Orbsen cell therapy in 4 different research laboratories across Europe and the project will culminate in a Phase 2a clinical trial of the therapy in the crippling inflammatory liver disease, Primary Sclerosing Cholangitis.
This is Orbsen's fourth success in attracting FP7 funding (the EU's Seventh Framework Programme for Research), making them one of Ireland's most successful private companies in this funding programme and now connects Orbsen to 23 global collaborators. Other successful cell therapy projects for Orbsen include PURSTEM (completed), REDDSTAR (ongoing) and DeCIDE (ongoing).
Orbsen Therapeutics Ltd. is a privately-held company founded in 2006 as a spin-out from Ireland's Regenerative Medicine Institute (REMEDI) in NUI Galway. As part of the PurStem EU FP7 program, Orbsen developed proprietary technologies that enable the prospective purification of highly defined and therapeutic (stromal) cells from several human tissues, including bone marrow, adipose tissue and umbilical cord.
Orbsen's CEO Brian Molloy said, "Orbsen has secured substantial amounts of research funding in the last 18 months which will further validate our product and bring us through to a "first in man" clinical trial in 2015/16. Our model has always focused on putting the 'science first' and we have successfully used that approach to develop a technology that could potentially position us and indeed Ireland at the leading edge of European Cell Therapy development."
Mr Molloy continued, "As a spin-out from the NUI Galway based REMEDI Institute we have focused the majority of our collaborations with an Irish research team. Our success in the MERLIN project now demonstrates that we are capable of playing a key role in collaborations led by researchers across Europe."
The total research budget for the MERLIN project is close to E6 Million of which E1 Million will go directly to Orbsen Therapeutics over the 4-year period of the project.
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Irish cell therapy firm in E6m research
Stem Cells in Anti-Aging Medicine: Workshop Preview
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Scientists Create Stem Cells From Adult Skin Cells
The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it #39;s all still a way off. Follow Christian Bryant...
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PUBLIC RELEASE DATE:
20-Apr-2014
Contact: Krista Conger kristac@stanford.edu 650-725-5371 Stanford University Medical Center
STANFORD, Calif. A single type of cell in the lining of the bladder is responsible for most cases of invasive bladder cancer, according to researchers at the Stanford University School of Medicine.
Their study, conducted in mice, is the first to pinpoint the normal cell type that can give rise to invasive bladder cancers. It's also the first to show that most bladder cancers and their associated precancerous lesions arise from just one cell, and explains why many human bladder cancers recur after therapy.
"We've learned that, at an intermediate stage during cancer progression, a single cancer stem cell and its progeny can quickly and completely replace the entire bladder lining," said Philip Beachy, PhD, professor of biochemistry and of developmental biology. "All of these cells have already taken several steps along the path to becoming an aggressive tumor. Thus, even when invasive carcinomas are successfully removed through surgery, this corrupted lining remains in place and has a high probability of progression."
Although the cancer stem cells, and the precancerous lesions they form in the bladder lining, universally express an important signaling protein called sonic hedgehog, the cells of subsequent invasive cancers invariably do not a critical switch that appears vital for invasion and metastasis. This switch may explain certain confusing aspects of previous studies on the cellular origins of bladder cancer in humans. It also pinpoints a possible weak link in cancer progression that could be targeted by therapies.
"This could be a game changer in terms of therapeutic and diagnostic approaches," said Michael Hsieh, MD, PhD, assistant professor of urology and a co-author of the study. "Until now, it's not been clear whether bladder cancers arise as the result of cancerous mutations in many cells in the bladder lining as the result of ongoing exposure to toxins excreted in the urine, or if it's due instead to a defect in one cell or cell type. If we can better understand how bladder cancers begin and progress, we may be able to target the cancer stem cell, or to find molecular markers to enable earlier diagnosis and disease monitoring."
Beachy is the senior author of the study, which will be published online April 20 in Nature Cell Biology. He is the Ernest and Amelia Gallo Professor in the School of Medicine and a member of the Stanford Cancer Institute and the Stanford Institute for Stem Cell Biology and Regenerative Medicine. He is also a Howard Hughes Medical Institute investigator. Kunyoo Shin, PhD, an instructor at the institute, is the lead author.
Bladder cancer is the fourth most common cancer in men and the ninth most common in women. Smoking is a significant risk factor. There are two main types of the disease: one that invades the muscle around the bladder and metastasizes to other organs, and another that remains confined to the bladder lining. Unlike the more-treatable, noninvasive cancer which comprises about 70 percent of bladder cancers the invasive form is largely incurable. It is expensive and difficult to treat, and the high likelihood of recurrence requires ongoing monitoring after treatment.
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Stanford scientists identify source of most cases of invasive bladder cancer
Ankle arthritis; 4 months after stem cell therapy by Dr Harry Adelson
Craig discusses his results from his stem cell therapy by Dr Harry Adelson for his arthritic ankle http://www.docereclinics.com.
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Ankle arthritis; 4 months after stem cell therapy by Dr Harry Adelson - Video
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Any clue to ageing problem http://www.howtolookyoungertip.jeunesseglobal.com.
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Dr. Al-Towerki on Saudi TV Dr. Al-Towerki on Saudi TV channel speaking about the successful stem cells operation at King Khaled Eye Specialist Hospital.
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Regenerative Medicine, Younger skin, hair regrowth, PRP, stem cells, stretch marks
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Why Integrative Medicine and Stem Cell Treatment
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Sweet Science Lesson! See How Stem Cell Therapy Works
http://www.innovationsstemcellcenter.com Call: 214.420.7970 Facebook: https://www.facebook.com/innovationsmedical Twitter: https://twitter.com/dallasdrj Inst...
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GTGP Dr Linzey Stem Cell Therapy
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Othropedic Surgeon Dr. Propper Speaks about Stem Cell Therapy - PRP - BMAC
Orthopedic Surgeon Dr. Propper Speaks about the Difference of Stem Cell Injection Therapy PRP - BMAC.
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What Can Be Treated With Stem Cells?
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