Embryonic Stem Cell Therapy – Video
March 21st, 2014 9:40 am
Embryonic Stem Cell Therapy
Short fun video about Stemaid #39;s Embryonic Stem Cells Visit http://www.stemaid.com.
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Embryonic Stem Cell Therapy - Video
Embryonic Stem Cell Therapy
Short fun video about Stemaid #39;s Embryonic Stem Cells Visit http://www.stemaid.com.
By: stemaid
See the rest here:
Embryonic Stem Cell Therapy - Video
PUBLIC RELEASE DATE:
20-Mar-2014
Contact: Tan Yun Yun tan_yun_yun@a-star.edu.sg 656-826-6273 Biomedical Sciences Institutes (BMSI)
1. Scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) have developed a method to generate human induced pluripotent stem cells (hiPSCs) from a single drop of finger-pricked blood. The method also enables donors to collect their own blood samples, which they can then send to a laboratory for further processing. The easy access to blood samples using the new technique could potentially boost the recruitment of greater numbers and diversities of donors, and could lead to the establishment of large-scale hiPSC banks.
2. By genetic reprogramming, matured human cells, usually blood cells, can be transformed into hiPSCs. As hiPSCs exhibit properties remarkably similar to human embryonic stem cells, they are invaluable resources for basic research, drug discovery and cell therapy. In countries like Japan, USA and UK , a number of hiPSC bank initiatives have sprung up to make hiPSCs available for stem cell research and medical studies.
3. Current sample collection for reprogramming into hiPSCs include invasive measures such as collecting cells from the bone marrow or skin, which may put off many potential donors. Although hiPSCs may also be generated from blood cells, large quantities of blood are usually required. In the paper published online on the Stem Cell Translational Medicine journal, scientists at IMCB showed for the first time that single-drop volumes of blood are sufficient for reprogramming into hiPSCs. The finger-prick technique is the world's first to use only a drop of finger-pricked blood to yield hiPSCs with high efficiency. A patent has been filed for the innovation.
4. The accessibility of the new technique is further enhanced with a DIY sample collection approach. Donors may collect their own finger-pricked blood, which they can then store and send it to a laboratory for reprogramming. The blood sample remains stable for 48 hours and can be expanded for 12 days in culture, which therefore extends the finger-prick technique to a wide range of geographical regions for recruitment of donors with varied ethnicities, genotypes and diseases.
5. By integrating it with the hiPSC bank initiatives, the finger-prick technique paves the way for establishing diverse and fully characterised hiPSC banking for stem cell research. The potential access to a wide range of hiPSCs could also replace the use of embryonic stem cells, which are less accessible. It could also facilitate the set-up of a small hiPSC bank in Singapore to study targeted local diseases.
6. Dr Loh Yuin Han Jonathan, Principal Investigator at IMCB and lead scientist for the finger-prick hiPSC technique, said, "It all began when we wondered if we could reduce the volume of blood used for reprogramming. We then tested if donors could collect their own blood sample in a normal room environment and store it. Our finger-prick technique, in fact, utilised less than a drop of finger-pricked blood. The remaining blood could even be used for DNA sequencing and other blood tests."
7. Dr Stuart Alexander Cook, Senior Consultant at the National Heart Centre Singapore and co-author of the paper, said "We were able to differentiate the hiPSCs reprogrammed from Jonathan's finger-prick technique, into functional heart cells. This is a well-designed, applicable technique that can unlock unrealized potential of biobanks around the world for hiPSC studies at a scale that was previously not possible."
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A*STAR scientists create stem cells from a drop of blood
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By: Jet Villa, InterAksyon.com March 17, 2014 7:45 AM
FILE PHOTO
InterAksyon.com The online news portal of TV5
MANILA - Five doctor-incorporators of the Philippine Society for Stem Cell Medicine (PSSCM) face charges and may have their medical licenses revoked for submitting a fabricated endorsement from the Professional Regulation Commission (PRC) to the Securities and Exchange Commission (SEC).
Among them are chairman of the Philippine Medical Association Leo Olarte, PSSCM treasurer and legal counsel; Bu Castro, secretary; Rey Melchor Santos, president; Oscar Tinio, vice president; and Jose Asa Sabili, chairman.
In a statement, PRC Chairperson Teresita Manzala on Sunday said she directed the Professional Regulatory Board of Medicine (PRBOM) to initiate, investigate, and file charges against the five doctors before the PRCs legal division for unprofessional, dishonorable, and unethical conduct.
Earlier on 10 January 2014, the SEC cancelled the registration of the PSSCM for submitting a fabricated document. In an order signed by SEC Acting Director Ferdinand Sales, the commission said the PSSCM had committed fraud in procuring its Certificate of Incorporation for its application for corporate registration.
Wherefore, premises considered, the Certificate of Registration of Philippine Society for Stem Cell Medicine with SEC Registration No. CN201303986, approved on March 6, 2013 is hereby revoked, the order reads.
Falsified endorsement
SEC said PSSCM submitted a 2ndPRC Indorsement, dated 20 February 2013, supposedly from Manzala. But on14 August 2014, SEC received a letter-complaint from Manzala informing the commission that the signature appearing in the alleged favorable indorsement from PRC was not hers and, thus, falsified.
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DINUKTOR | 5 stem cell society doctors face raps for submitting falsified PRC endorsement to SEC
Leo Olarte, M.D., PMA president. PHOTO from http://www.philippinemedicalassociation.org
MANILA, Philippines Politics over stem cell treatment may be behind the move to slap an ethics case against him for allegedly falsifying signatures, the Philippine Medical Association (PMA) president said.
In an interview over Inquirer Radio 990 AM on Monday, Dr. Leo Olarte said he found it suspicious that Professional Regulation Commission (PRC) Chair Teresita Manzala announced the ethics case against him on the day of the elections for the next PMA president.
He claimed Manzala slapped the ethics case before the PRC to ruin his chances of being re-elected in the countrys largest doctors association.
Olarte said Manzala has connections to doctors who are against stem cell medicine. Olarte is a supporter of stem cell treatment.
Manzala released the statement on the day of our elections specifically to destroy my name Manzala (also) has connections to doctors who are against stem cell. I am pro-stem cell treatment while my rival (for president) is not, Olarte said in Filipino.
In a Philippine Daily Inquirer report on Sunday, Olarte and his four predecessors were charged with fraud in the registration of the Philippine Society for Stem Cell Medicine (PSSCM) in the Securities and Exchange Commission.
Olarte and the four others Bu Castro, Rey Melchor Santos, Oscar Tinio and Jose Sabili were accused of forging Manzalas signature in an endorsement for the incorporation of the PSSCM.
But Olarte blamed a syndicate behind the alleged forgery.
He said the PMA paid a private trading company to process the PSSCMs incorporation with the SEC. The doctor did not name the company.
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Stem cell politics behind forgery chargesPMA president
By: Jet Villa, InterAksyon.com March 17, 2014 7:45 AM
FILE PHOTO
InterAksyon.com The online news portal of TV5
MANILA - Five doctor-incorporators of the Philippine Society for Stem Cell Medicine (PSSCM) face charges and may have their medical licenses revoked for submitting a fabricated endorsement from the Professional Regulation Commission (PRC) to the Securities and Exchange Commission (SEC).
Among them are chairman of the Philippine Medical Association Leo Olarte, PSSCM treasurer and legal counsel; Bu Castro, secretary; Rey Melchor Santos, president; Oscar Tinio, vice president; and Jose Asa Sabili, chairman.
In a statement, PRC Chairperson Teresita Manzala on Sunday said she directed the Professional Regulatory Board of Medicine (PRBOM) to initiate, investigate, and file charges against the five doctors before the PRCs legal division for unprofessional, dishonorable, and unethical conduct.
Earlier on 10 January 2014, the SEC cancelled the registration of the PSSCM for submitting a fabricated document. In an order signed by SEC Acting Director Ferdinand Sales, the commission said the PSSCM had committed fraud in procuring its Certificate of Incorporation for its application for corporate registration.
Wherefore, premises considered, the Certificate of Registration of Philippine Society for Stem Cell Medicine with SEC Registration No. CN201303986, approved on March 6, 2013 is hereby revoked, the order reads.
Falsified endorsement
SEC said PSSCM submitted a 2ndPRC Indorsement, dated 20 February 2013, supposedly from Manzala. But on14 August 2014, SEC received a letter-complaint from Manzala informing the commission that the signature appearing in the alleged favorable indorsement from PRC was not hers and, thus, falsified.
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DINUKTOR | 5 stem cell society doctors face raps for submitting falsified document to SEC
PRC: Stem cell group submitted fake SEC registration. At a press conference in Manila on Monday, March 17, Professional Regulation Commission chairperson Teresita Manzala said the PRC endorsement documents allegedly submitted by the Philippine Society for Stem Cell Medicine (PSSCM) to the Securities and Exchange Commission (SEC) were fabricated and have her tampered signature. The SEC previously revoked the corporate registration of the PSSCM. Danny Pata
In a statement, Professional Regulation Commission (PRC) chair Teresita Manzala said she has asked the Professional Regulatory Board of Medicine (PRBOM) to initiate, investigate and file charges against doctors Leo Olarte, Bu Castro, Rey Melchor Santos, Oscar Tinio and Jose Asa Sabili before the PRCs legal division.
Olarte is the current president of the PMA.
The five doctors are all incorporators of the Philippine Society for Stem Cell Medicine (PSSCM,) which was able to obtain an SEC certificate despite previously being denied corporate registration. They were able to do this, said the statement, by submitting false PRC endorsements to the commission.
The PRBOM eventually got hold of a copy of the SEC Registration. On examination of the supposed PRC Endorsement, it was noted that the reference regulatory law used was the Philippine Veterinary Law of 2004, instead of Republic Act 2382, otherwise known as the Medical Act of 1959, and there appeared a signature of the PRC Chairperson, the PRC statement said.
Manzala said complaints were filed against the doctors for unprofessional, dishonorable and unethical conduct.
According to the statement, the incorporators later denied participation in obtaining the SEC registration, instead naming a Dr. Mike Aragon as the person who obtained the certification.
In a notarized affidavit submitted to the PRBOM, 'Dr. Mike Aragon' declared that he was the person authorized to register a corporation to be called 'Philippine Society for Stem Cell Medicine' and admitted paying 15,000 pesos to a trading company for them to file the necessary documents for incorporation of the PSSCM, the PRC statement said.
But Aragon claimed to have had no participation whatsoever in the actual processing of the SEC papers for incorporating the PSSCM. Patricia Denise Chiu/BM, GMA News
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