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Coping with calamity: Former NYT columnist Frank Bruni on blindness and vision, at Morristown book fest keynote – Morristown Green

October 15th, 2022 1:44 am

Frank Bruni has seen many people and places over the last quarter-century as a correspondent and columnist for the New York Times.

Because of a rare vision disorder, he now lives with the knowledge that soon he may not see anything.

Bruni, 57, writes about taming that anxiety, and about aging and the hard-earned wisdom it brings, in The Beauty of Dusk, On Vision Lost and Found. On Friday, he kicked off the ninth Morristown Festival of Books in a free-wheeling, often humorous conversation with MSNBC anchor Katy Tur.

If you focus on all the bad that can happen that will become your life, that fear, that paralysis. What have you accomplished? Bruni said during the hour-long keynote at the Mayo Performing Arts Center, where he also touched on politics, the pitfalls of social media, the process of writing, and the pressures of college admissions.

The festival and its junior spinoff, KidFest, continue all day Saturday, Oct. 8, 2022, with free talks in downtown churches and the library by 60 authors. Tickets are $60 for the closing session with best-selling author James Patterson (Blowback).

Bruni awakened one morning in late 2017 with blurry vision in his right eye. Doctors told him a rare stroke had cut off blood to an optic nerve, rendering that eye functionally blind. They warned of a 20 percent chance the same thing could happen in his left eye.

For months, he faced the dawn with anxiety: Would he wake up blind?

A pair of clinical trials were dead ends. One study involved a series of injections directly into his faulty eyeball. Clamped eyelids kept him from blinking.

So you feel like youre Malcolm McDowell in A Clockwork Orange, Bruni recounted, to laughter from the large crowd.

The Beauty of Dusk offers examples of people persevering despite major disabilities a limb lost in wartime, early-onset Parkinsons disease, blindness. Many times we avoid asking individuals about their afflictions, out of politeness or concerns about making them uncomfortable. These are missed opportunities for insights, according to Bruni, who discovered that people were eager to share their stories for his book.

Gradually, he adopted a sunny view of his situation.

I think for a lot of us, there is a zone in which we can choose to be more positive or negative, Bruni said.

You can decide to be angry, and legitimately so. Where does that get you? You can decide to do a tally of all the things that are unavailable to youWhere does that get you? Or you can say, What do I have left?'

Driving at night has become problematic, and parallel parking is out. Reading can be a struggle. Yet Bruni knows things could be worse.

How lucky am I, or any of us who have vision disabilities, to be living at a moment in time when you can control the font size of just about everything?

Bruni said he even scammed the Times into sending him to a Greek island, the source of one of his trial drugs.

Bruni became a media professor at Duke University last year. He has covered the White House, the Persian Gulf War, and the AIDS crisis. Times assignments included Rome bureau chief, restaurant critic, and columnist; he also has appeared regularly on CNN and taught at Princeton. The Beauty of Dusk is his fifth book.

His most popular work, Where You Go Is Not Who Youll Be, took aim at college admissions.

I think weve done a hideous disservice to young people by changing their middle school and high school experiences into this terrifying period whereeverything they do is passed through the prism of how this will look to a bunch of strangers in Princeton, New Jersey, Bruni said.

Its really parents who have to change this, stop telling their kids that this school is better than that school because it rejects more people.

Fielding audience questions, Bruni and Tur who on Saturday will discuss her second book, Rough Draft agreed that writing is hard.

I kind of hate it, said Tur, 38, who anchors MSNBCs Katy Tur Reports. Her advice: Let the words cascade, then start pruning.

Although Bruni once banged out an Ivanka Trump column in 20 minutes, other pieces could take hours, he said. I dont have a process. Just a lot of hope and a keyboard.

When words dont come, he advised pausing. Take a run. Take a showerhave a cocktail.

Bruni and Tur said they dread man on the street interviews. They also admitted suffering from Imposter Syndrome, described by Tur as the fear that interview subjects will think youre an idiot.

Both were critical of social media. Blasted repeatedly by President Trump, Tur turned off her Twitter account before publishing her best-seller Unbelievable, My Front-Row Seat to the Craziest Campaign in American History.

Its a liberating feeling to release yourself from that jail, she said. It can ruin you. In reality, Twitter is a very small portion of the population who have not-representative opinions about most issues.

It was supposed to be a means and a tool of connection, and its become an agent of division, Bruni added. People use social media to hunker down deeper and more consistently in their own micro-tribes.

Most importantly, a young listener wanted to know how Bruni, a University of North Carolina graduate, feels about teaching at archrival Duke. Bruni got booed for that new affiliation while delivering a commencement address at his alma mater.

When the Tar Heels play the Blue Devils in basketball, Im Switzerland, Bruni insisted.

I view it all with anthropological curiosity.

MORE ABOUT THE 2022 MORRISTOWN FESTIVAL OF BOOKS

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Coping with calamity: Former NYT columnist Frank Bruni on blindness and vision, at Morristown book fest keynote - Morristown Green

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Sighting solutions in a world of vision for weavers – The New Indian Express

October 15th, 2022 1:44 am

Express News Service

CHENNAI: It was during the pandemic that FM RadioCity received a call from Suresh, a weaver describing his tough fight with cataract and a plea for help as his profession depended on his vision. Providing a solution to the problem, Dr Mohan Rajan, chairman and medical director, Rajan Eye Care Hospital, collaborated with RadioCity and provided free checkup and treatment to the weaver. This initiative that began for Suresh has now extended as the Weavers Vision Project, serving 10,000 weavers in the silk belt ofthe state.

Service for a lifetime

Celebrating World Sight Day 2022 at the Rajan Eye Care Hospital, T Nagar, organised by Chennai Vision Charitable Trust and Rotary Rajan Eye Bank, the event witnessed the distribution of privilege cards to the weavers of Thiruvannamalai, Kanchipuram, Cheyyar, Vellore and Arani. Dr Vishnu Prasad, MP, gave the cards to almost 300 weavers, and applauded the initiative. The privilege cards will authorise the weavers to get free consultations, retino surgery, glasses and other eye health services, free for their entire life, said Dr Mohan. He also educated the audience on the importance of eyesight and the awareness of eye related problems. India contributes to 1/5th of the global blindness with 25 million people affected by blindness. If a kid loses his/her eyesight, he or she will lose 33 working years. For adults it is eight years of loss of working years, he explained.

Initiatives through years

The event also shed light on the fact that India is the largest producer of blindness, cataract disease and children with blindness in the world. Even though there is the case of curable blindness due to various reasons like cracker injury, diapetic retinopathy, short-sightedness or long-sightedness, the doctors confirmed that most people arent aware of the treatment they had to undergo and the various schemes available for reducing the economic burden on these treatments. Providing a solution to the array of problems, Rajan Eye Care started their eye bank in 1991.

With several ambassadors, the project has reached millions of people and the institution continues to spread awareness on corneal blindness and the importance of eye donation. In 2005 their initiative, Blind Free India - A Reality, started organising eye donation rallies every year, reiterating the slogan, Daanathil siranthathu Kandanam, Kankale erikartheerkal, puthaikartherkal (The greatest donation is eye donation, dont bury or burn them).

The hospital also took the tertiary eye care services to the rural doorstep. Now, the latest initiative empowering the weaving community aims to create a better future for them and provide help to a major part of the working sector of the country. Guest of honour, Dr Nandakumar N, district governor, R.I Dist 3232, summed up, We need to support weavers and understand that their job is a seasonal play and requires a lot of effort. With collaborations like this, we can provide help to more people.

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Blindfold run raises $40,000 for the MUHC Foundation to support glaucoma care at the MUHC – StreetInsider.com

October 15th, 2022 1:44 am

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MONTREAL, Oct. 13, 2022 (GLOBE NEWSWIRE) -- Quebecers will have access to better glaucoma care thanks to one intrepid ophthalmologist. Dr. Hady Saheb, a glaucoma specialist at the MUHCs McGill Academic Eye Centre (MAEC), pledged to run 50km while blindfolded to raise $40,000 for the MUHC Foundation in support of glaucoma care. With the help of a sighted guide, he completed his run and raised $40,000 the process.

I treat patients who have become blind or have a medical condition that could cause vision loss.Blindness is one of the most devastating conditions a patient can live through, and glaucoma is one of the leading causes of blindness in Canada and worldwide. With better awareness we can prevent blindness. I ran blindfolded because I wanted to put myself in the shoes of those who live with vision loss and blindness, and better understand their struggles and fears.

Dr. Hady Saheb, Glaucoma specialist and ophthalmologist, McGill Academic Eye Centre, McGill University Health Centre

Dr. Saheb completed his final 5km on Friday, October 7th with supporters looking on. He hopes that his run will raise awareness of glaucoma and encourage more people to have regular eye exams. The funds raised will support equipment and programs to help individuals living with glaucoma, vision loss and blindness receive the very best care.

We are inspired by Dr. Sahebs determination and empathy. He already provides life-changing care in his clinic every day, but he went the extra milequite literallyto ensure the well-being of his patients. We are grateful to him for his support of the MUHC Foundation, which will in turn provide important resources to the McGill Academic Eye Centre.

Julie Quenneville, President and CEO, McGill University Health Centre Foundation

Glaucoma is one of the leading causes of blindness for people over 60 years of age. The most common form is caused by a build-up of pressure in the eye. The pressure damages the optic nerve, leading to vision loss or blindness. Most frightening of all, glaucoma can develop without warning signs, putting more individuals at risk. Thanks to Dr. Saheb, fewer Quebecers will experience blindness as a result of glaucoma.

About the McGill University Health Centre Foundation

The McGill University Health Centre (MUHC) Foundation raises funds to support excellence in patient care, research and teaching at the McGill University Health Centre, one of the top university hospitals in Canada. Our Dream Big Campaign to change the course of lives and medicine is raising millions of dollars to solve humanitys deadliest puzzles: infectious diseases; end cancer as a life-threatening illness; fix broken hearts through innovative cardiac care; detect the silent killersovarian and endometrial cancersearly; create the best skilled health care teams in Canada; and much more. We are rallying our entire community to solve the worlds most complex health care challenges.

Tarah Schwartz Director, Communications & MarketingMcGill University Health Centre Foundation [emailprotected]

Kelly AlbertSenior Communications OfficerMcGill University Health Centre Foundation [emailprotected]

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/bc9096a3-9224-40c2-ad20-54c1e72492f2

Blindfold Run raises $40 000 for the MUHC Foundation

Dr. Hady Saheb and Dr. Sherin Al-Safadi

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MacKenzie Scott Donates $15M to Address the Eyecare Needs of the Impoverished – InvisionMag

October 15th, 2022 1:44 am

MacKenzie Scott is known for her philanthropy. If fact, shes rewriting the philanthropy playbook.

Makes sense in a way. She is an author.

When Scott and Amazon founder Jeff Bezos divorced in 2019, she instantly became one of the richest people in the world. Shortly thereafter she declared her intention to donate her entire fortune approximately $38 billion to charity. She seems to be right on track.

Scott eclipsed the $12 billion mark in lifetime donations earlier this year. Shes already donated to more than 1,200 organizations. Her philanthropy efforts havent skipped a beat since the recent announcement that she filed for divorce from her second husband.

VisionSpring announced today it is the most recent recipient of Scotts charity. The nonprofit accepted a $15 million gift from Scott. The money will go toward the organizations new initiative Livelihoods in Focus, a $70 million effort to correct the vision of more than 6 million people by 2030.

VisionSprings mission is to bring affordable eyewear to some of the poorest areas in the world. Scotts donation is believed to be the largest single private donation toward addressing the eyecare needs of individuals in poverty.

VisionSpring said it will focus on low-income tea, coffee, cocoa and artisan workers in India, Bangladesh, Ghana, Kenya and Uganda. To donate to VisionSpring click on this link.

World Sight Day is observed around the world every second Thursday in the month of October. Lions Club International started the observance in 2000 as part of its annual SightFirst campaign to fight blindness. The International Agency for the Prevention of Blindness (IAPB) joined the initiative that year as well.

It has become a global day of awareness and giving for those in need of adequate eyecare.

The INVISION Magazine e-mail inbox is proof. Weve received numerous correspondences highlighting World Sight Day-centric initiatives.

It truly is inspiring.

The World Council of Optometry (WCO) joined forces with IAPB to promote their #loveYourEyes campaign. The goal was to get 5 million eye tests pledged globally from September 13 to October 13. That impressive number was eclipsed with a day to spare.

Warby Parker has teamed with Jonas Philanthropies to address vision disability with the Warby Parker Pupils Project. The initiative, which began in 2015, gives children access to proper vision care by taking vision screenings and eye exams to their classrooms. It is taking place in New York City, Washington, D.C., Baltimore, California and Pennsylvania. Warby Parker is known for its buy a pair give a pair that gives glasses to individuals in need. Jonas Philanthropies in 2016 launchedJonas Childrens Vision Careto prevent blindness and treat vision disorders.

SightSavers is marking World Sight Day 2022 with a new Eye Health Equals campaign along with a manifesto for change directed at world governments. The non-profit works on preventable blindness in more than 30 counties, primarily in Africa and Asia. The group is calling on world governments to:

And, lastly, dont forget that the IAPB World Sight Day 2022 Photo Competition continues through Oct. 22. It is open to both amateur and professional photographers. Submitted images should capture what it means to have healthy vision. Photos will be judged in five categories: Your Eyes, Health for All, Everyone Everywhere, Hope, and Eye-Sights. You can submit your photos by following this link.

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Retirement Calculator | Northwestern Mutual

October 15th, 2022 1:42 am

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Northwestern Mutual is the marketing name for The Northwestern Mutual Life Insurance Company and its subsidiaries. Life and disability insurance, annuities, and life insurance with longterm care benefits are issued by The Northwestern Mutual Life Insurance Company, Milwaukee, WI (NM). Longterm care insurance is issued by Northwestern Long Term Care Insurance Company, Milwaukee, WI, (NLTC) a subsidiary of NM. Investment brokerage services are offered through Northwestern Mutual Investment Services, LLC (NMIS) a subsidiary of NM, brokerdealer, registered investment adviser, and member FINRA and SIPC. Investment advisory and trust services are offered through Northwestern Mutual Wealth Management Company (NMWMC), Milwaukee, WI, a subsidiary of NM and a federal savings bank. Products and services referenced are offered and sold only by appropriately appointed and licensed entities and financial advisors and professionals. Not all products and services are available in all states. Not all Northwestern Mutual representatives are advisors. Only those representatives with Advisor in their title or who otherwise disclose their status as an advisor of NMWMC are credentialed as NMWMC representatives to provide investment advisory services.

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The Longevity Investors Conference Gstaad brought together longevity experts and deep-pocketed investors – Cointelegraph

October 15th, 2022 1:42 am

Longevity Investors Conference brought together high level scientists, clinicians and investors who all agreed on one big goal: Bringing the concept of longevity to life. Longevity experts and visionaries joined the conference, such as George Church, professor of genetics at Harvard Medical School; Aubrey de Grey, chief of science offices at SENS Research Foundation; Brian Kennedy, director at Center for Healthy Longevity and professor of the biochemistry and physiology departments at National University of Singapore; Charles Brenner from Alfred E. Mann Family Foundation and chair of diabetes and cancer metabolism at Beckman Research Institute of City of Hope; Christian Angermayer, founder of Apeiron Investment Group; Eric Verdin, president and CEO of Buck Institute for Research on Ageing; Nir Barzilai, director of the Institute for Ageing Research at the Albert Einstein College of Medicine; Michael Greve, founder of Forever Healthy Foundation; Evelyne Yehudit Bischof, associate professor, internal medicine specialist and longevity physician at Human Longevity Inc.; Alex Zhavoronkov, founder and CEO of Insilico Medicine; Phil Newman, founder of First Longevity and editor-in-chief at Longevity.Technology; Wei-Wu He, executive chairman at Human Longevity Inc., chairman and CEO of CASI Pharmaceuticals Inc. and chairman and founder of Genetron Health; and many more.

Longevity Investors Conference, being the most exclusive conference for longevity investors, brought together over 130 investors from around the globe. The investors as well as the speakers had the chance to see the Startup Showcase that took place on Day One of the conference in partnership with Phil Newman from Longevity Technology. The Startup Showcase provided the chance to some of the most promising longevity startups to present their work and ideas, such as Tom Weldon, founder, chairman and CEO of Ponce De Leon Health; Nikolina Lauc, co-founder and CEO of GlycanAge; Stan Watowich, founder and interim CEO of Ridgeline Therapeutics; Owen Phillips, CEO of BrainKey; Nika Pintar, co-founder and CEO of Ani Biome; and Bruno Balen co-founder of Ani Biome.

The venue, Le Grand Bellevue Hotel in Gstaad, recently rated the Hotel of the Year by Swiss media, was privatized for the LIC guests ensuring an exclusive networking experience. There were many networking opportunities over the course of the two days during the networking dinners and lunches and especially during coffee breaks and receptions held in the Longevity Lounge, where guests could get the exclusive chance to experience the latest trends in longevity therapies and treatments from exhibitors.

The ending of the Longevity Investors Conference was marked by a gala dinner, during which the Maximon Longevity Prize Award Ceremony took place. Elisabeth Roider, partner and chief scientific and medical officer at Maximon explained from a scientific point of view that translation efforts from computational biology to wet lab approaches to clinical trials are needed on the way. Many small steps will be required while the big picture should be in place. The prize is especially important, as it highlights the effort that is needed to identify safe and new ways to target ageing, the need for large clinical trials, which investigate the effect of interventions on ageing, and the importance of mental health, platforms and AI in future longevity medicine.

Marc Bernegger, one of the driving forces behind the conference, said: There are more and more traditional investors joining the longevity space, which creates massive investment opportunities. The special setup of this years conference enables not only knowledge exchange but also effective community-building, which is very unique for the industry and has never happened before to this extent. Berneggers partner and LIC co-founder, Dr. Tobias Reichmuth, added: The longevity industry will be one of the biggest investment opportunities over the next decade, expected to be worth at least $600 billion by 2025. It is experiencing a great momentum, and this is the ideal time to use it in favor of educating and spreading the information to investors. In an ocean of scientific-oriented conferences, a professional and global investor-focused longevity conference such as LIC provides an opportunity for the industrys top investors and innovators to get acquainted with recent developments and breakthroughs.

The next Longevity Investors Conference will be held in the Autumn of 2023. Participation is open for registration on the website.

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Do you think ageing can be reversed? Here are 12 longevity startups to watch – Sifted

October 15th, 2022 1:42 am

The quest to slow down ageing and have healthier and longer lives is ongoing. And its not just about living to 120.

Some scientific research suggests that in years to come, we will have therapeutics that will help us foresee age-related diseases like diabetes and cancer as well as neurodegenerative diseases and prevent them. Other scientific breakthroughs on animals have shown that it may also be possible to add years to our fertility window, stop our hair from turning grey and perhaps even vaccinate ourselves against ageing.

However, until the answer to that billion-dollar question is found, there is a lot we can do to trick the ageing process, say researchers, startups and investors.

In 2021, about $1.9bn globally was invested in the longevity sector. That number is set to increase both because various clinical trials are getting results and because theres an increased interest among investors in the space.

As with many healthtech trends, longevity is yet to get the same recognition in Europe as it has in the US. Still, with the global longevity market projected to reach $44bn by 2030, Europe and the UK and Switzerland in particular is waking up.

So, apart from the more well-known startups like TreeFrog Therapeutics and Rejuveron, which are the other longevity startups to watch? And what problems are they solving?

Founded: 2020, by Maria Blasco and Ftima Bosch (University of Barcelona spinoff)

One of the key reasons we age is the protective caps at the end of our chromosomes, called telomeres, shortening over time. When they fully disintegrate, it causes our DNA to become damaged. Telomere Therapeutics is developing a telomerase gene therapy that counteracts telomere shortening and can treat age-related diseases.

Funding: Undisclosed amount by Spanish Invivo Ventures

Founded: 2018 by Alex Schueller, James McCully, Pedro del Nido and Sitaram Emani

Age-related deterioration of the mitochondria in our cells is associated with an array of conditions, such as heart disease, stroke, diabetes, Parkinsons and Alzheimers. Researchers have recently discovered that this process can be reversed with cellular energisers such as Lipo Glutathione, Lipo CoQ10, Lipo Apigenin and Lipo Resveratrol that help restore and preserve mitochondrial function. Cellvie is working on a way of transplanting mitochondria directly into compromised cells.

Funding: $5m in a seed round in 2021 from German investor KIZOO Technology Capital.

Founded: 2018 by Guido Kroemer, James Peyer, and Sebastian Brunemeier within Apollo Ventures company builder

Autophagy is a natural process in which the bodys cells clean out any damaged or unnecessary components. However, more and more evidence suggests that autophagic dysfunction is a cause of neurodegenerative diseases such as Alzheimers and Parkinsons. By restoring autophagy in such diseased cells Samsara says it can remove the misfolded protein. However, its still in the pre-clinical phase.

Funding: $10m Series A in 2021 by global longevity VC Apollo Health Ventures, Swiss Korify Capital and US-based Longevitytech Fund

Founded: 2020 by Lorna Harries, Ben Lee and Kirsty Semple (spinout from University of Exeter)

As we age, more and more of our cells stop dividing and become senescent, or zombie cells. These cells dont die but are major contributors to age-related illnesses such as cancer, dementia and cardiovascular disease. Seniscas treatment rejuvenates these cells. The spinout is developing a treatment through senotherapeutic interventions that target the senescent cells. By restoring the splicing factor a protein to how it is in younger cells, Senisca hopes to turn back the ageing clock in old cells.

Funding: 2m in seed funding by US-based APEX ventures and the local UK investor VC QantX in June 2022

Founded: 2017 by Jens Gruber and Herbert Stadler

Senescence and other biological processes such as cell development, growth and repair are helped by the main actors of intercellular communications exosomes. The signals from exosomes can either stimulate or suppress immune responses. Curexsys is focused on the work to develop and manufacture exosomes in clinical quality for regenerative medicine and anti-ageing therapies.

Funding: 8.2m Series A in 2020 by the German pharmaceutical Sartorius

Founded: 2017 by Espen Riskedal and Karl Trygve Kalleberg

Testing your blood for biomarkers (such as cholesterol level and haemoglobin) has become increasingly popular and is also one way to understand your individual longevity. So what are the biomarkers to look out for if you are destined for a long healthy life? Age Labs is a Norwegian molecular diagnostics company that discovers, develops and commercialises diagnostic tests for the early detection of age-related diseases. It also has a biological age predictor.

Funding: In total $2m, including a $1m pre-seed round in 2020 by Norwegian Skyfall Ventures and Aleap.

Founded: 2017 by Ann Belin

When we reach our 50s our muscles start losing their functions and mass. This is called chronic sarcopenia and it contributes to an increased risk of disability, falls and fractures. Rejuvenate has a screening platform that investigates dysregulated pathways in ageing. Dysregulated pathways can occur due to mutations that cause genes and proteins to be expressed abnormally, leading to diseases. Rejuvenates first drug candidate is RJx-01, to be used in acute and chronic sarcopenia types of musculoskeletal diseases. According to the company it also has been shown to have beneficial effects in the prevention and treatment of other age-related diseases.

Funding: Rejuvenate Biomed raised its 15.7m Series B in 2021 from Zrich-based Rejuveron Life Sciences (now majority owner) and Luxembourg-based Vesalius Biocapital.

Founded: 2021 by Pascal Rode, Sophie Chabloz, Teresa Budetta

The interest in the nine hallmarks of ageing is no longer limited to the corridors of science labs, and intermediate fasting, exercise and healthy living are not enough for some people. As a result, the longevity supplement industry is growing. Products like NMN nicotinamide mononucleotide is a precursor to NAD+, the essential coenzyme and key metabolite found in every cell of the human body are increasingly popular. Supplement startup Avea believes it can optimise long-term health as well as slow and even reverse some of the signs of ageing with its products.

Funding: 2.4m seed round led by Swiss investor and startup builder Maximon

Founded: 2007 by Pierre Landolt and Patrick Aebischer

Cellvie is working on transplanting mitochondria but what if you could decrease the deterioration of the mitochondria in our cells by taking a supplement? After a decade of research and clinical trials, based on the ingredients of pomegranate juice, supplement startup Amazentis has developed its first product with a pure form of Urolithin A. The substance has been proven to help counter age-associated cellular decline and improve muscular strength.

Funding: Raised $8.9m Series C in 2018 by the Swiss corporation Nestl Health Science

Founded: 2019 by Peter Ward and Michael Geer

Humanity wants to bring longevity to the masses by helping people control what they eat and when, their exercise regime and their sleeping habits. Its developed an app that calculates customers rate of ageing and biological age by drawing on data from your smartphone and wearable devices to track biomarkers such as heart rate, step rate, sleep, activity and eating habits. Its grown to 130k users in the last 12 months.

Funding: $5m over a split seed round in 2020 and 2021 by UK- based 7percent Ventures, Estonian investor Taavet Hinrikus, US-based One Way Ventures and others

Founded: 2014 by Nora Khaldi

Peptides are strings of amino acids, which are the building blocks of proteins. Collagen peptides are commonly used in skin products to rejuvenate skin, but can peptides also prolong a healthy life? Recent research indicates that some types of peptides could be beneficial in slowing down the ageing process although, more research is needed. Using AI and peptidomics, Nuritas aims to discover bioactive peptides that can be used to optimise glucose metabolism, regain muscle strength and rejuvenate skin.

Funding: $45m Series B funding round in 2021 by US-based Cleveland Avenue, UK-based Grosvenors Wheatsheaf Group, and the European Circular Bioeconomy Fund among others.

Founded: 2021 by Rob Konrad Maciejewski and James Raaff

There are a lot of companies selling longevity supplements, checking your blood markers and biomarkers and even looking at how your DNA may be working for or against you when it comes to certain age-related diseases. But how do you put all that information together into a longevity package that is right for you? Biolytica is doing that by combining health data analytics and personalised longevity programmes. So far its focusing on healthcare professionals but it hopes to be able to offer it to everyday customers in the future.

Funding: 10m from Swiss company-builder Maximon

Mimi Billing is Sifteds Nordic correspondent. She also covers healthtech, and tweets from@MimiBilling

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‘SNL’ Gig Was a Risk Rob Lowe Credits for His Longevity: ‘I Had People in My Life Telling Me – TheWrap

October 15th, 2022 1:42 am

Rob Lowes starring role in the Fox series 9-1-1: Lone Star stands as only the latest capstone in a Hollywood career full of them.

And if its his last, hes had a good run more than 100 TV and film credits over a span of 43 years.

Lowe, in an interview published Friday by ET Online, credited his longevity to a force of will that led him to take risks that paid off. One of those risks was the hosting job on Saturday Night Live, a gig he said several people close to him advised him not to take.

If you want to do it a long time, be prepared to be brave and say Yes to things that maybe other people in your life are going to be worried about, Lowe, 58, advised to up-and-coming actors and other TV and film artists. I mean, I had people in my life telling me not to hostSaturday Night Live. I know today it seems like everybody does it, but there was a time when people were like, I dont know. They could make fun [of you].'

Lowe said that intuitive skills and a persevering spirit were also key.

Know that there are going to be ups and downs and talent will prevail, Lowe added. It really does. If youve got it, then you can survive the down periods of your career. Every career, it doesnt matter. Itll cycle around and keep cycling around and just keep cycling around and you just got to have your staying power.

Lowe first took the SNL leap in March 1990. During that experience, he befriended legendary cast member Mike Myers. Their relationship led Lowe to a starring role in the hit 1992 comedy Waynes World, as villainous TV producer Benjamin Oliver, and later, smaller roles in three Austin Powers films.

I love that Im still so close to Mike Myers, Lowe told ET Online. But never in a million years thinking it would lead toWaynes Worldand then toAustin Powers. You just never know where life is gonna take you.

Lowe has hosted SNL two more times, in April 1997 and October 2000. And the job, indeed, did not come without risk.

In the 2000 appearance, Lowe was signing off per tradition, surrounded on stage by the familiar smiling faces of the Saturday Night Live cast, musical guest Eminem and political activist Ralph Nader, who had made a guest appearance in the episode. Actor Brendan Fraser was also there, standing just behind Lowe. Fraser had made a brief, nonspeaking cameo in the episode, and perhaps perturbed he wasnt used for more, began repeatedly yelling Bedazzled the name of Frasers next film that would open in theaters a month later as Lowe was taking the show off air.

Ive spent many years trying to figure out what was going on with Brendan that night, Lowe said last year on his Literally! podcast. And the nearest I can come to, is that he was somehow promised a walk-on during the show, and the show ran long, and he just was like, F it, Im gonna go up and yellBedazzledbehind Rob Lowes head.

The SNL experience had also led to confusion at a critical juncture years earlier, Lowe said in the ET Online interview.

I remember I was getting married and we kept it a secret, we kept it out of the media. We were able to have a nice, sweet low-key wedding and Lorne Michaels called me to say I had to go to a preproduction meeting ofWaynes World,' Lowe said of the TV and film producerand SNL creator. He says, You need to be there. The studio needs to talk to you. And I said, Lorne, Im getting married in 20 minutes and he said, Well, maybe you can come by for dessert. That was my, Ill never forget that.

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'SNL' Gig Was a Risk Rob Lowe Credits for His Longevity: 'I Had People in My Life Telling Me - TheWrap

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Wellness and longevity brand Serotonin Centers to open in Nashville – Tennessean

October 15th, 2022 1:42 am

Wellness and longevity brand Serotonin Centers announced it plans to open three new facilities in the Nashville area.

Serotonin Centers was established in Florida by 15-year fitness industry veteran Eric Casaburi, who said he noticed there weren't any businesses dedicated to helping those interested in improving and preserving their health while experiencing aging at the same time.

Serotonin Centers says it is the first franchise brand to focus focuses solely on providing anti-aging and hormone treatments.

'What I want to do is cure cancer':The patients that inspire Vanderbilt's new oncology director

Different membership tiers for wellness and longevity treatments are available, and the services include aesthetic enhancement, hormone restoration, immunity and recovery treatments, and weight control.

Recently, doctors Jody Junia and Olumuyiwa Olu Esuruoso have been added to the Serotonin team as health experts to aid with rolling out the three Nashville-area centers.

With their passion and professional backgrounds, Doctors Junia and Esuruoso will play a vital role in connecting the Serotonin brand and services to the great people of Nashville, said Casaburi.

Junia and Esuruoso said they are looking forward to utilizing their medical expertise to help customers optimize their health and quality of life.

My focus has always been on treating illnesses and finding cures for the ailments patients are suffering from, Esuruoso said. But this opportunity with Serotonin gives us the chance to work preemptively, providing people with the tools and services they need to protect their well-being and prevent a range of health-related hardships from taking hold in the first place.

In addition to the Nashville facilities, five additional Serotonin Centers have been announced in New Jersey, the first of which broke ground in Colts Neck in August. Serotonin revealed earlier this year that a franchisee had raised $6.5 million to open five centers in Orlando.

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4 Recipes With Corn, Beans, and SquashThe Three Sisters Ingredients That Blue Zone Centenarians in Costa Rica Eat Every Day – Well+Good

October 15th, 2022 1:42 am

In Costa Rica, pura vida has become much more than just a slogan; its a way of life. The popular expression, which translates to pure life, has been used by locals for decades as a casual way of saying everythings good or as a way to describe Costa Rican lifestyle and culture.

As the saying pura vida indicates, Costa Ricans certainly know a thing or two about living life to the fullest, as its the home to some of the longest-living people in the world. Nicoya, an 80-mile peninsula in Costa Rica just south of the Nicaraguan border, has been identified by longevity expert, bestselling author, and National Geographic researcher Dan Buettner as one of the five Blue Zones regionsaka the parts of the planet that are home to the oldest-living peopledue to its abundance of centenarians.

So, whats the key to healthy aging for many folks residing in the Nicoya Peninsula? Aside from maintaining a strong sense of purpose, feeling connected to their community, and moving throughout the day (as well as a number of other longevity-boosting lifestyle habits), Costa Ricans tend to consume a healthy diet comprised of a trifecta of super nutritious ingredients dubbed the three sisters, aka corn, beans, and squash. Weve gathered a few delicious, nutrient-rich three sisters recipes made with these ingredients that will bring a bit of pura vida to wherever you reside.

The three sister ingredientscorn, beans, and squashstem from the traditional Mesoamerican diet that many Nicoyan centenarians follow. People in this region tend to eat light dinners early in the evening, comprised of these simple, nutritious foods. Most meals in the Nicoya Peninsula incorporate plant-based, nutrient-dense, and protein-rich ingredients like legumes and vegetables (which make up about 21 percent of their diet), three sisters included.

According to Blue Zones research, squash, beans, and corn are grown together, eaten together, and celebrated together, as they provide a symbiotic growing relationship, as well as a complete nutritional profile. When growing, the corn provides a trellis for the beans, beans add nitrogen to the soil, and the squash shades out the weeds. Nature is incredible, right?

What's more, just like they complement and support one another as they grow in a field, the three sisters pair even more perfectly together when cooking delicious, nutrient-dense meals. Corn provides gut-healthy fiber plus tons of vitamins and phytochemicals that help combat inflammation in the body. Meanwhile, beans are rich in protein and fiber, and squash yields antioxidants, vitamins, and minerals, including vitamin A, calcium, magnesium, and a host of carotenoids. Plus, when consumed together, these plant-based foods form what's known as a complete protein, meaning they provide your body with all nine essential amino acids. And then there's the incredible versatile flavor profile of these foods; you'd be hard-pressed to find an ingredient that corn, beans, and squash don't pair with.

Ready to incorporate corn, beans, and squashthe perfect fall foodsinto your every dish? Read on for some delicious, easy to make three sisters recipes.

Photo: Veg Kitchen

While you certainly dont have to eat the three sisters ingredients together every single time, it may be one of the best ways to get the most amount of nutrients in one serving. If productivity is the name of the game, this easy three sisters stew recipe by Veg Kitchen might catch your attention. Its made with (you guessed it!) tender squash, protein-packed beans, and fresh corn and comes together in less than an hour. Aside from being a perfect hearty weeknight meal, it can also be the perfect veggie-forward side dish for Thanksgiving dinner, too.

Get the recipe: Three Sisters Stew

Photo: Simply Recipes

Just like the three sisters have the perfect symbiotic relationship when planted close to one another (as they have traits that nurture and help the others grow), this vegetarian three sisters casserole with cornbread topping recipe by Simply Recipes is a match made in heaven. Its packed with anti-inflammatory spices like chili powder and nutrient-dense greens like spinach or kale. Plus, the casserole gets finished with a delicious crunchy cornbread biscuit topping thats simply irresistible.

Get the recipe: Three Sisters Casserole with Cornbread Topping

Photo: Brand New Vegan

Fall is officially here, and that means cozy and comforting soups all season long. This simple three sisters stew recipe by Brand New Vegan can be made in just about half an hour and is just as nutrient-dense as it is delicious to eat. Aside from our favorite three sisters, this recipe also has other nutritious staple ingredients like lycopene-rich tomatoes and fiber-rich potatoes. So, the next time youre struggling with what to make for dinner (yet again), consider this dish your problem solved.

Get the recipe: Three Sisters Stew

Photo: Suwannee Rose

If your favorite cowboy caviar recipe got a major gut-healthy and protein-packed glow-up, it would definitely become this sisters harvest bowl recipe by Suwannee Rose. This delicious dish has our favorite longevity-boosting ingredients plus a healthy serving of grains (in this case, quinoa), which happens to be another one of the must-have foods Nicoyans eat on a daily basis. After all, on average, 26 percent of the Nicoyan diet is based on whole grains like quinoa. Plus, quinoa is also a great source of calcium and folate, and its full of fiber, with five grams per serving.

Get the recipe: Sisters Harvest Bowls

An herbalist shares a brain-boosting herbal shot for longevity:

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Lesley Stahl on longevity of ’60 Minutes’: ‘That clock is still there’ – USA TODAY

October 15th, 2022 1:42 am

Trump cut short '60 Minutes' interview with Lesley Stahl

President Trump cut short an interview with '60 Minutes' correspondent Lesley Stahl and has since leaked the session before its Oct. 25 airing.

USA TODAY

NEW YORK Lesley Stahl doesn't back down.

The unflappable TV journalist has been with CBSfor 50 years 31 of those as a correspondent for venerablenewsmagazine "60 Minutes." In that time, she hasbecome known for her remarkable poise and dogged pursuit of the truth,refusing to throw softball questions to contentious interview subjects such as former President Donald Trump, who memorably cut shorttheir 2020 sit-down.

"A lot of heads of state have walked out on me," says Stahl, 80, sitting at her desk on a recent rainy morning after a workout. "I'm not saying I'm proud of it, but it does signify thatI'm not afraid to ask a question that a head of state isn't going to like. I see that as my role and I see their role as being accountable for their actions, whether they're a dictator orthe head of a democracy."

Lesley Stahl: How 'Marcel'landed '60 Minutes' correspondent for the perfect cameo

'60 Minutes': Top moments from Trump's combative interview with Lesley Stahl

Half a century into her CBS career,Stahl remains as vigorous and relevant as ever. For the 55thseason of "60 Minutes" (Sundays, 7 EDT/PDT),she traveled to Taiwan to report on how people are responding to the country'sheightened threat from China. After stopping home in New York for a day to repack her suitcase, she flew to Tehran to interviewIranian President Ebrahim Raisi.

"That would have anybody flat on their back, but she manages her time unbelievably well, and then she's on to the next thing," says Bill Owens, executive producer of "60 Minutes." "There's nobody I'd rather be in a foxhole with than Lesley Stahl. She's fearless and fair and one of the hardest working people I've ever met."

Stahl was hired by CBS News in 1972 as part of the network'saffirmative action program, along with journalists Connie Chung and Bernard Shaw. As a young reporter, she cut her teeth covering the Watergate scandal and impeachment hearings of President Richard Nixon, under the tutelage of Washington bureau chief William J. Small.

"I was lucky," Stahl says. "I felt very little of what you would call discrimination because I was a woman. The boss said, 'This is an important program, and we're all getting behind it.' And when the boss says it, it's in the air."

Before joining "60 Minutes" in 1991, she was a moderator for "Face the Nation," grilling dignitaries such as the U.K.'sprime minister, Margaret Thatcher, and former Secretary of State George Shultz, after theIran-Contra affair. These and other interviews earned her areputation of being tough a label that Stahl disputes.

"The word 'tough' is interesting to me because I've always been called tough," Stahl says. "I called up my dad once and said, 'Dad, they say I'm tough.' And he said:'You're not. Tough is firing someone.You've never had to do that.' So I'm not tough my dad said so. (Laughs.)I am persistent, and it's to a fault. I will ask (a question) five times and I've been metaphorically slapped around for it."

According to Nielsen, "60 Minutes" averages 9 million viewers a week, and ended the 2021-22 TV season as the No. 1 news program. Stahl believes the newsmagazine, which launched in 1968,has maintained a consistently large audience for decades because the format hasn't changed, with in-depth segments covering a broad spectrum of topics including politics, science and the arts.

"We're old-fashioned," Stahl says. "We still try our hardest to be unbiased and give all sides. And people have comfort when they see we haven't changed that clock is still there."

Stahl is unsure whether "60 Minutes" will be around for another 55 seasons. ("I don't know if we can become something on our phone," she explains. "Our pieces are 13 to 15 minutes long.") But she has no desire to leave anytime soon.

"I climbed a mountain last year. I was very proud of that," Stahl says, recalling a "grueling" shoot withmountain gorillas in Rwanda. "I'm always kind of examining myself now: Am I less sharp? Can I do this job physically? I remember going to (one of the show's producers) and saying:'When I feel like I'm losing it, I'll come to you. I'll be the one to march in here.' And he said:'No you won't. No one ever does that.'"

Stahl won a legion of young fans this summer thanks to her meta cameo in family film"Marcel the Shell with Shoes On," in which she interviewed the animated mollusk for a spot-on recreation of a "60 Minutes" segment. In the movie, released in June, Marcel is a Stahl superfan who praises her for having "class" and blowing cases "wide open" compliments that "embarrassed" the journalist the first time she watched the film. (She now has a 3D-printed Marcel "trophy" on her desk, with a plaque reading "Lesley Stahl is fearless" a quote from the movie.)

More than a dozen family photos adornher cozy Midtown office, the same one she hashad since shestarted at "60 Minutes." Some of her 13 Emmy Awards line the bookshelves,with file boxes of research tucked away on the floor.

"The last 30 years, I've lived in this room," Stahl says."They asked me if I wanted to move, and at first I said, 'Can I have a bigger office?' And then I thought, 'Well, I can't move. All my junk is here.'"

Stahl has one daughter, Taylor, and two grandkids, ages 9 and 11. Her husband, writer Aaron Latham, diedin July at 78 after a long battle with Parkinson's disease. They met while she was a reporter covering Watergate and were married in 1977.

"Everything that's happened to me has happened while I've been here (at CBS): my marriage, my children, my grandchildren," Stahl says. "And my career is a really central part of me, so this is my whole life, really."

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The Search for a Pill That Can Help Dogsand HumansLive Longer – WIRED

October 15th, 2022 1:42 am

halioua began 2020 with $5.1 million in funding. By way of thanks she sent all of her investors, including Rosen, fluffy toy puppies wearing company bandanas. She secured an office on the edge of downtown San Francisco, but the lease began in March, the same month the Bay Area became the first part of the US to enter pandemic lockdown. Her companys formative months, and first hires, took place via Zoom, Slack, and eventually socially distanced meetups. Halioua raised another $6 million and hired scientists, veterinarians, and an expert in getting new animal drugs past the FDA.

She embraced the role of dog company CEOpainting a mural of a giant German shepherd in Loyals office and ordering shirts with the slogan Save the dogs, save the world. She adopted a fluffy white husky named Wolfie, whom she has described as her cofounder and Loyals chief evangelist. Her management style, she says, was informed by her bad experiences at Oxford. When she talks to her team about her goals or beliefs, she tries to pair her statements with evidence to convince her workers that the boss is being straight with them. Even if you dont trust me, you still know this is true, she says.

Haliouas new science team, including a scientist who previously led aging research at pharma giant Regeneron, helped refine her original idea. They identified a compound they believed could be given to young dogs of the largest breeds, such as French mastiffs, to delay their accelerated aging process. They found a second compound they thought could target processes that cause cognitive decline and kidney problems in older dogs of all sizes.

As her company gained traction, Halioua noticed certain patterns in her business interactions. She tried to recruit women investors but found it difficult because there werent many to ask. When she met with investors who were men, some would try to flip a business meeting into a date, and others would confidently explain science to her that she knew inside out. Mostly she brushed off such momentsher time at Oxford had lowered her expectations of those with more power and prestige than her.

She often felt different. Describing herself as an Oxford dropout helped convince people to take her seriouslynever mind that she had left her PhD in part due to dissatisfaction with a harassment investigation, a circumstance missing from the dropout tales of archetypal boy geniuses like Mark Zuckerberg. She listened to hundreds of Silicon Valley podcasts to try to learn the industrys patois. She trained herself to smile less and wrote in a blog post aimed at women entrepreneurs: I come off as more of a grump now, but I am a grump who has the money she needs to build her company.

In the spring of 2021, Halioua published a blog post about her Oxford PhD supervisor titled The Gifts of My Harasser, leaving him nameless. She described the paradox of one of her worst experiences laying a foundation stone for her later successes by teaching her to be skeptical of social hierarchies and institutional power. Its been two years since I left. I am not broken anymore, but I still feel the cracks, she wrote. His abuse shattered my preconceived notions of how the world worked and cleared a path I otherwise never would have found.

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Supontis vs Dogecoin, Which Cryptocurrency Has Greater Longevity In The Market? – Coinpedia Fintech News

October 15th, 2022 1:42 am

Supontis (PON) and Dogecoin (DOGE) are two very different coins.

One is a technical cryptocurrency created to improve the cross-chain transfer of various digital currencies like Ethereum, Binance, and Tron. The other is a meme coin that prides itself on seamless peer-to-peer transactions and a lively community.

Nonetheless, both have one thing in common. They are part of a growing change in the crypto economy that is not entirely focused on financial gain.

Because traditionally, investors immersed themselves in the crypto universe for the sole purpose of making a healthy return in the future.

And if you look at the trajectory of Bitcoin (BTC), the masses had a point. Less than one year ago, Bitcoin peaked at $67,549.74. This means that savvy investors who exchanged Bitcoin for fiat during this time walked away with a huge profit.

Indeed, the goal of making money from crypto is unlikely to cease. But its fair to say that not all crypto geeks are actively looking to withdraw their finances. In actuality, some people want a bit of crypto to remain in their wallet for trading or communal purposes.

The interesting predicament now is, which type of modern crypto will trend in the market for the longest time? Will investors continue to gravitate towards meme currencies or will more technical coins be better off in the long run?

Dogecoin is statistically the most popular meme coin of all time. At the time of writing, it is ranked number 10 on coinmarket and possesses a market cap of $7,915,648,509.

Its funny how Dogecoin started as just a meme. No one in the crypto world expected it to become so lucrative until an extremely rich and famous dude known as Elon Musk, decided to tweet about the coin in April 2019 and the rest is history.

Dogecoin undoubtedly gained a massive boost from the multi-billionaire. Nevertheless, the coin deserves credit for offering its users enough value from super fast and cheap transactions to keep them invested.

In contrast to Dogecoin, Supontis was not invented as a meme.

The cryptocurrency consists of a bridge platform that is built on the BNB Smart Chain and facilitates the cross-chain transfer of different assets. This is ideal for crypto nerds who like to seamlessly move their coins from one market to another.

But this is just the tip of the Supontis tsunami. Supontis also provides its users with a high level of security, extremely fast transactions, and low transaction costs.

Supontis quick transaction speeds are particularly notable as this allows it to compete with the likes of Dogecoin and Solana.

Final Thoughts

Supontis and Dogecoin both represent coins that deviate away from cryptocurrencys original concept.

You only need to look at Dogecoins market cap to see that it has no shortage of investors. However, the currency is experiencing a downward trend which could imply that individuals are moving away from meme coins.

Meanwhile, Supontis is still very new on the crypto scene and may have better potential. After all, with crypto on the rise, the need for easy and smooth exchange between different currencies is becoming more crucial.

If you would like further information about Supontis, check out the links below:

Presale: https://register.supontis.com

Website: http://supontis.com/

Telegram: https://t.me/SupontisTokenOfficial

Disclaimer: This is a press release post. Coinpedia does not endorse or is responsible for any content, accuracy, quality, advertising, products, or other materials on this page. Readers should do their own research before taking any actions related to the company.

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Louisville Zoo says goodbye to one of world’s oldest gorillas – Evening News and Tribune

October 15th, 2022 1:42 am

It is with heavy hearts that the Louisville Zoo announces the passing of female western lowland gorilla Helen.

Affectionately called the Grand Dame of the gorilla world, Helen was much celebrated at 64 years old. She long impressed Zoo fans with her big personality and longevity.

Helen had been on quality of life watch and was in natural age decline for several months. Zoo caregivers made the difficult decision to euthanize Helen Friday.

At 64, Helen enjoyed remarkably good health for most of her life, with only expected age-related arthritis and some periodontal disease. However, she recently developed increasing instability and tremors. This put her at greater risk of falling which impacted her day-to-day welfare.

A typical median life expectancy for a female zoo gorilla is about 39 years. Helens longevity is only matched by Fatou, a gorilla at Zoo Berlin that is 65 years old.

The title Grand Dame was bestowed on Helen because of her senior status and for her honored role as a mother of three, a grandmother of 17, a great-grandmother of 21, a great-great-grandmother of 8, and finally, a great-great-great-grandmother of one. Two of her progeny, Bengati (great-grandchild) and Kindi (great-great-grandchild) reside at the Louisville Zoo.

Letting go of a special gorilla like Helen is very hard, but it is often the last, best thing we can do for our animals, said Louisville Zoo Director Dan Maloney. Helens exceptional longevity is not only a testament to her personal constitution, but also to the outstanding care provided by her keeper team and the animal health care staff over these past 20 years. Helen was one of our most beloved ambassadors. Her fascination with human babies delighted families for decades. I know our friends and members will share in her loss and miss her greatly.

Helen was a legend and she deserved the best, said Louisville Zoos Senior Veterinarian Dr. Zoli Gyimesi. Besides the Zoos staff that cared for her daily, she had her own dentist, cardiologist, gynecologist, neurologist, and orthopedist/pain manager. Helen taught us much about gorillas and geriatric gorilla care.

Helen inspired us all with her longevity, added Kristen Lucas, Ph.D. and Chair of the Gorilla Species Survival Plan with the Association of Zoos and Aquariums. She touched the lives of many people over the years, including those who cared for her and those who just spent time visiting her at the Zoo. She was an independent spirit as well as being an integral member of her gorilla family, and her legacy lives on.

Helen came to the Zoo in 2002 from Lincoln Park Zoo. Because she was wild born in West Africa (Cameroon), her birth year was estimated as 1958. The Louisville Zoo recognized Helens birthday annually in January to celebrate her being the oldest gorilla in North America and the second oldest gorilla in the world.

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‘Prolong your lifespan’: 5 ‘cheapest’ foods that can boost longevity – Express

October 15th, 2022 1:42 am

As the prices of pretty much everything are creeping up,Express.co.ukspoke to a dietician about budget-friendly foods that can also boost your longevity. While theres no secret recipe for longer life, one key approach to longevity lies in staving off the precursors of chronic disease. From a lower risk of stroke to a reduced risk of heart disease, some cheap foods do this with gusto.

While its no secret that colourful fruit and veg as well as fibre-packed pulses are some of the healthiest foods out there, these longevity staples can be often taxing on your wallet.

Fortunately, Karine Patel, private dietitian and founder of Dietitian Fit & Co, has shared how to keep your budget tight and your body healthy during the ongoing cost-of-living crisis.

Patel said: Contrary to what we often hear, eating healthy doesnt need to be expensive.

You can create a multitude of healthy meals on a low budget while prolonging your lifespan.

READ MORE:The 'first noticeable' sign that cholesterol is dangerously clogging your arteries

The expert listed some of the cheapest foods you can get in the UK supermarkets, while also adding a few years onto your lifespan.

Patel said: According to a study, published by researchers at Harvard, eating three portions of vegetables and two servings of fruits daily is associated with a lower risk of premature death.

Whats more, the process of freezing doesnt strip the colourful, nutritious foods of any goodness, the expert explained.

While cheesy chips wont do much good for your arteries, theres no need to ditch potatoes altogether.

In fact, the starchy vegetable packs potassium, which can reduce your risk of a stroke and prolong your lifespan, according to the dietician.

She said: [Plus,] they are a long-lasting food, and they are usually less than 1/ kg."

Another popular side dish, rice can be bought for as little as 45p/kg and served with plenty of veggies.

Patel said: According to the Blue Zones (areas in the world where people tend to live longer lives), 65 percent of their diet consists of rice, which makes it one of the healthiest and cheapest dishes.

READ MORE:Golden milk can shorten the time it takes to fall asleep and make you sleep longer

While pasta in a rich sauce is considered pretty indulgent, switching up your regular choice for a wholewheat option could do plenty for your health.

Patel said: Wholewheat pasta is rich in fibres, and regular consumption of fibres is associated with lower risk of cardiovascular disease, which in turn reduces the risk of mortality."

Extremely cheap and so versatile, beans are an excellent source of fibre and protein.

The dietician added: They are a staple among people who live the longest lives, multiple studies suggest that consuming beans could prolong your life expectancy by multiple years.

Last but not least, tomatoes offer vitamin C, potassium, folate, as well as vitamin K.

The juicy fruit is also one of the best sources of carotenoid, an antioxidant that has been shown to protect against age-related disease.

From fragrant curries to warming stews, the expert suggested that you can make a variety of dishes perfect for winter, using these cheap ingredients.

Patel added: Always look at the unit pricing to check the price of a food for a specific unit of weight (or volume).

It helps to compare the real price difference between products. This will tell you how much youre paying per gram or kg (or ml) so you can compare packages and get the best deal.

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FOXO Technologies Announces First Distribution Partner and Begins Product Rollout in California; Expands Executive Team With Insurance Industry Talent…

October 15th, 2022 1:42 am

MINNEAPOLIS, October 12, 2022--(BUSINESS WIRE)--FOXO Technologies Inc. (NYSEAM: FOXO), a technology platform company whose products and services seek to address long-standing, core problems within the life insurance industry through epigenetic longevity science, today announced that its insurance distribution subsidiary, FOXO LIFE, recruited its first distribution partner, California-based BGA Insurance, to begin rolling out Life Insurance Designed to Keep You Alive to agents across the state. FOXO also announced the appointment of James Grauel, Jr. as Chief Distribution Officer ("CDO") of FOXO LIFE to spearhead the launch of longevity-focused life insurance products with independent agents.

FOXO LIFE is partnering with leading independent insurance agencies across the United States who share its vision and goal of modernizing the industry. Grauel joins the team with decades of experience working in the life insurance industry from both the carrier and independent agent distribution viewpoints. As CDO, Grauel will manage the development of FOXO LIFEs network of independent agents selling longevity science-powered life insurance.

"I am thrilled to join a team that is building the most exciting thing Ive seen in this industry over the course of my career," said Jim Grauel, Jr., Chief Distribution Officer of FOXO LIFE. "Creating more value for life insurance consumers by aligning their healthy longevity with the natural financial interest of life insurance carriers is an incredible and obvious innovation the industry needs."

FOXO LIFE will be holding its first agent distribution rollout events in Southern California with BGA Insurance, its first broker-general agent, who represents over 4,000 independent agents who are now able to sell life insurance products with FOXO LIFEs Longevity Report.

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"We are excited to work with FOXO LIFE to bring our agent base the opportunity to reframe the life insurance conversation from death protection, to life, health, and longevity," said Barry Zimmerman, President. "The real game changer will be when FOXO LIFE introduces saliva-based underwriting protocols to mitigate the need for blood and urine specimen collection."

FOXO LIFEs first agent recruitment events will be held:

October 19th in Huntington Beach

November 1st in San Diego

November 2nd in Los Angeles, El Segundo

November 3rd in Sacramento, Roseville

For agents interested in attending an event contact Alicia at sales@foxolife.com or 888.405.8957.

"We like to say that FOXO LIFE was created by agents, for agents," said Jon Sabes, Founder and CEO of FOXO. "This means that the products and services we are bringing to market are designed to address major industry pain points that fall most directly on agents. Making it easier and more exciting for agents to sell life insurance is our first order of business."

Todays news comes four weeks after FOXO became a publicly traded company on the New York Stock Exchange American under the symbol "FOXO" via its merger with Delwinds Insurance Acquisition Corp ("Delwinds"), valuing the combined company at an estimated enterprise value of $369 million.

About FOXO Technologies Inc. ("FOXO")

FOXO is a technology platform company focused on commercializing longevity science through products and services that serve the life insurance industry. FOXO's epigenetic technology applies AI to DNA methylation to identify molecular biomarkers of human health and aging. FOXO seeks to modernize the life insurance industry by simplifying the consumer underwriting journey with saliva-based biomarkers and enhancing life insurances consumer value proposition with the FOXO Longevity Report. For more information about FOXO, visit http://www.foxotechnologies.com. For more information about FOXO LIFE, visit http://www.foxolife.com. For investor information and updates, visit https://foxotechnologies.com/investors/.

No Offer or Solicitation

This press release shall not constitute a solicitation of a proxy, consent or authorization with respect to any securities or in respect of the proposed transaction. This communication shall not constitute an offer to sell or the solicitation of an offer to buy any securities, nor shall there be any sale of securities in any states or jurisdictions in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of such state or jurisdiction. No offering of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act of 1933, as amended or an exemption therefrom.

Forward-Looking Statements

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Timeless: USM Arts and Sciences Faculty Members Ball, Meade Cite Love for Students, Teaching as Keys to Longevity in Profession – The University of…

October 15th, 2022 1:42 am

Fri, 10/14/2022 - 09:08am | By: David Tisdale

Left: USM English Professor Dr. Angela Ball is presented a portrait of the Aubrey K. Lucas Administration Building by USM College of Arts and Sciences Dean Dr. Chris Winstead, a gift signifying 40 or more years of service, along with induction into the universitys Centennial Legacy Circle Right: USM Art Professor Jim Meade is presented his 50-year service pin by USM College of Arts and Sciences Dean Dr. Chris Winstead.

A teacher affects eternity; he or she can never tell where their influence stops. Henry B. Adams

Long before social media, cell phones and Zoom meetings expanded the physical spaces between us, University of Southern Mississippi (USM) Professors Angela Ball and Jim Meade began establishing an in-person legacy cementing their reputations as among the best to hold forth in a classroom at the institution.

Meade came to the USM Hattiesburg campus in 1971 to join the faculty of its then Department of Art, as an assistant professor, with Dr. Ball following at the close of the decade as a visiting instructor of English in 1979. Together they have logged nearly 100 years in classrooms at the institution, and this fall resisted yet again the siren call of retirement, returning to do what they love most - teaching and inspiring their students products on canvases and through the written word.

For Meade, the pathway in life that led to USM wasnt easy. He grew up in poverty, and the tragic deaths of close family members in his teen years left him with the responsibility for three younger siblings. But he found great joy during that time as a Boy Scout in teaching the lessons of scouting to his younger cohorts in their quest for badges, along with working as a swimming instructor during the summer months. These experiences, he says, eventually revealed for him a career he felt suited for and wanted that of an educator - and his passion for it has not waned, even in the autumn of his life.

After studying for two years at the University of Virginia-Wise, Meade transferred to East Tennessee State University, where he earned bachelors and masters degrees in art before attaining an MFA from the University of Georgia. He has studied under established international artists, and his work has been on display in approximately 140 exhibitions, including 40 one-man shows and 17 overseas. Hes also lectured at universities in Asia and Europe.

As he pondered his job options upon approaching graduation at ETSU, one of Meades professors, Morton Brown, shared some sage advice.

The real action in higher education is at the state universities, Brown told him. These kids heading to the elite private schools - Harvard, Yale, Princeton - theyve got everything already education, money, privilege. Even if they dont graduate from college, they can fall back on their familys wealth or make their way in life through their talent, political, and economic connections.

The majority of our (ETSU) students are blue collar, working-class, first-generation college students much like those at other state (public) universities, Brown continued. These are the students working their way up from less privileged circumstances, and at these schools you get an opportunity to be a part of their success story.

USM Art Professor Jim Meade confers with a USM art student about the collection of compositions she will include in her senior project.

Meade feels USM holds a similar profile, and hes proud of his own students from the same kind of backgrounds who have gone on to paint self-portraits of success.

Many of the kids Ive taught here over the years are now living all around the world, enjoying interesting and rewarding careers in the arts, he said. Its gratifying to see what theyve accomplished.

As for his teaching philosophy, Meade says it is important to set the terms for instruction and be honest and consistent with your students.

Voltaire (the French philosopher) once said Gentlemen, define your terms. Well, teaching is a kind of deviation of that expression, Meade said. As an educator, I believe you should define the terms that make up your instruction and stay in the boundaries of those terms. I spend a good bit of the first part of a semester defining the terms.

Dr. Ball is a member of the USM English Programs prestigious Center for Writers faculty. She holds a bachelors degree from Ohio University, and MFA in Creative Writing (poetry emphasis) from the University of Iowa, and a Ph.D. from the University of Denver.

From 2013 to 2015, Dr. Ball was USMs Moorman Distinguished Professor of Humanities. Her extensive vita includes six volumes of poetry and hundreds of individual poems in prestigious publications such as the New Yorker and the Atlantic Monthly. She has served as editor of the Mississippi Review and as a Poet-in-Residence at the University of Richmond; shes been listed in Whos Who of American Writers and Editors and included in the Best American Poetry anthologies. She earned the Susan B. Herron Award for highest ranked fellow by the Mississippi Arts Council, along with multiple awards from the Mississippi Institute of Arts and Letters.

I'm as dumbfounded as anyone that I have been doing this for so long, she said. But I enjoy meeting the students and feel grateful every day for the immense variety of them that we have, both undergraduate and graduate students. It's particularly great to see some who perhaps struggled in the past to open up, like slightly late blossoms, to reading and learning.

I find if I encourage them to respond honestly to the readings, good things are bound to happen. There's a constant back-and-forth of ideas and inspiration, most intensely with the graduate poets and writers, but also often with undergraduates.

Dr. Ball recounts when, for an advanced composition class, she gave an assignment based on Studs Terkel's book of interviews, Work. A student in that class interviewed a sanitation worker, who at length extolled the virtues of his job: good pay and benefits, and best of all, you are always finding stuff! People throw out lots of valuable things. This is one of the best interviews I've read anywhere.

It's experiences like these and others that bring Dr. Ball back to the classroom, what she sees as opportunities to get out of myself, be surprised, help, and learn.

I come back to get out of myself -- to avoid a tendency to brood and/or feel sorry for myself, she said. My life, like most people's, has had a measure of heartache and I would much rather hear my students' poems, essays, and class discussion than give in to that.

This past August, Dr. Ball taught an intersession class in world literature, and a student woke her up to a detail in a story she has taught several times, misreading it because she had previously ignored it.

The same class was asked, on the example of Jamaica Kincaid's brief story, "Girl," to impersonate a parent giving harsh advice, Dr. Ball continued. A Black student read an inspired list of things to avoid doing as a young Black man, a list that ended up dauntingly long. The class responded with a burst of appreciative finger-snaps.

And there's nothing more satisfying for her as a teacher, she explains, than finding out a poem shes helped a student edit has been published, or even an entire dissertation.

But yet, maybe there is something more satisfying, she reconsidered. To see a light go on somewhere inside a student who has struggled with writing and sees, "Yes, I can say things simply and clearly. "

Dr. Angela Ball discusses the latest assignment with students in a USM Center for Writers fall 2022 graduate seminar.

Kevin Walters, a Hattiesburg native and two-time graduate of USM who lives in Nashville, says a day does not go by that hes not benefitted in some way -- either directly or indirectly -- from what he learned in the classes he took from Professors Ball and Meade.

Professor Ball's poetry classes -- particularly those focusing on the work of poet Elizabeth Bishop -- broadened my perspective about art, writing, and the world in ways I had never experienced before. Similarly, Professor Meade was the kind of instructor who enlightened you about the history of art, even as he pushed you to do more and better drawings yourself.

I would be remiss if I did not mention their accomplishments outside the classrooms, and how their work as artists fed what they taught in their classes.

Earlier this year, Meade and Dr. Ball were recognized for their years of service to the university in an event hosted by the USM Department of Human Resources, where Dr. Ball was presented a portrait of the Aubrey K. Lucas Administration Building, a gift signifying 40 or more years of service, along with induction into the universitys Centennial Legacy Circle; Meade was presented his service pin for 50 years-plus as a faculty member. The ceremony had been delayed due to the COVID-19 gathering restrictions of the last two years.

I so appreciated the lovely ceremony where the wonderful Jim Meade and I were recognized, Dr. Ball said. To be lauded for doing what we love is indeed lucky.

I will treasure the special portrait of the Dome given to me. In my imagination it is a portrait of me standing in front of a blackboard - or a white board - marveling at what my students have to say.

USM President Emeritus Dr. Aubrey K. Lucas says hes honored to count Meade and Dr. Ball as treasured colleagues and friends from their time together at the university.

Theyre both great artists and effective teachers, and certainly deserving to be honored for their exemplary work over the years as senior members of our faculty, Dr. Lucas continued.

Reflecting on his half century-plus career at USM, Meade has no regrets. I wouldnt change a thing, he said, adding that he hasnt set a date for calling it quits.

Ive done it for so long, I dont think I can break the habit. I really cant imagine doing anything else.

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Timeless: USM Arts and Sciences Faculty Members Ball, Meade Cite Love for Students, Teaching as Keys to Longevity in Profession - The University of...

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Diabetes Symptoms, Causes, & Treatment | ADA

October 15th, 2022 1:41 am

Understanding Gestational Diabetes

Gestational diabetes can be a scary diagnosis, but like other forms of diabetes, its one that you can manage. It doesnt mean that you had diabetes before you conceived or that you will have diabetes after you give birth. It means that, by working with your doctor, you can have a healthy pregnancy and a healthy baby. No matter what, know that you have all the support you need for both you and your baby to be at your best.

We dont know what causes gestational diabetes, but we know that you are not alone. It happens to millions of women. We do know that the placenta supports the baby as it grows. Sometimes, these hormones also block the action of the mothers insulin to her body and it causes a problem called insulin resistance. This insulin resistance makes it hard for the mothers body to use insulin. And this means that she may need up to three times as much insulin to compensate.

The key to treating it is to act quicklyas treatable as it is, gestational diabetes can hurt you and your baby. Work with your doctor to keep your blood glucose levels normal, through special meal plans and regular physical activity. Your treatment may also include daily blood glucose testing and insulin injections.

Read More on Gestational Diabetes

In addition to type 1, type 2, and gestational diabetes, a small minority of people develop specific types of diabetes due to other causes. This includes:

Because these types of diabetes are rare, they are often misdiagnosed as other types of diabetes. You can learn more about these types of diabetes in the Classification and Diagnosis of Diabetes section in the Standards of Medical Care in Diabetes. If you think you might have one of these types, be sure to talk with your doctor.

More on Diabetes from Other Causes

When it comes to prediabetes, there are no clear symptomsso you may have it and not know it. Heres why thats important: before people develop type 2 diabetes, they almost always have prediabetesblood glucose levels that are higher than normal but not yet high enough to be diagnosed as diabetes. You may have some of the symptoms of diabetes or even some of the complications.

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A nutritionist with type 1 diabetes shares the top 5 ‘food swaps’ she eats to manage her blood sugar – CNBC

October 15th, 2022 1:41 am

More than 11% of Americans have diabetes, which occurs when the pancreas does not produce enough insulin to regulate blood sugar levels.

As a nutritionist who has been living with type 1 diabetes for more than 30 years, I've found that having diabetes doesn't mean you have to completely stop eating what you enjoy. Managing blood sugar is often more about making small food swaps, or adding, rather than eliminating, certain foods.

For example, you can still eat carbs, but you also need to add protein, a small amount of healthy fats and plenty of fiber. Protein, fat and fiber all moderate how quickly food is digested, which is helpful in balancing blood sugar levels.

Here are the foods I eat and the foods I try to cut back on to help manage my diabetes:

Turning vegetables into noodles using a spiralizer is a great way to increase your fiber and vitamin intake.

Floortje | Getty

Wheat-based pasta is mostly carbohydrates, and it can lead to a blood sugar spike if eaten in large portions on its own.

Instead, I'll opt for bean-based pasta or a vegetable pasta. Turning vegetables (e.g., carrots, zucchini and sweet potatoes) into noodles using a spiralizer is a great way to increase your fiber and vitamin intake.

If you do choose to eat traditional pasta, whether it's gluten-free or wheat-based, be sure to add lots of protein and fiber to your dish. I recommend poultry, fatty fish like salmon and beans, and vegetables like kale, peppers, onions and broccoli.

As a substitute for grain rice, try riced broccoli, mushrooms, zucchini, chickpeas or cauliflower. These are fiber-rich and gentler on blood sugar.

Cavan Images | Getty

As a substitute for grain rice, try riced broccoli, mushrooms, zucchini, chickpeas or cauliflower. These are fiber-rich and gentler on blood sugar.

Brown rice is a common substitute for white rice in diabetes diet plans, but the carbohydrate amounts in both are actually pretty similar. And the small amount of additional fiber you get from brown rice isn't typically enough to have a significant impact on blood sugar levels.

So, just as with pasta, when you want to enjoy some rice, just be mindful of your portion size and pile on the protein, fat and fiber (e.g., from nuts, veggies, fish, or beans).

To make these chocolate chip almond butter breakfast bars, I use a combination of ground up oats (or oat flour) and almond flour. This combo creates a more blood sugar-friendly flour that also gives a great fluffy texture!

Mary Ellen Phillips

Instead of using traditional flour when baking or cooking, I'll opt for blood sugar-friendly flour made from almonds, coconuts or oats.

One of my favorite tricks is to use a blend of almond flour and oat flour. The resulting flour is lower in carbohydrates and higher in fiber and protein than wheat flour.

And it's equally tasty: This chocolate chip almond butter breakfast bars recipe is delicious!

Breakfast cereal can do a number on your blood sugar if you're not careful. Instead of choosing cereals with large amounts of added sugars, opt for brands that have more fiber and protein.

ATU Images | Getty

Breakfast cereals can do a number on your blood sugar if you're not careful. Instead of choosing cereals with large amounts of added sugars, choose brands that have more fiber and protein.

My recommendation for a high-fiber, low-sugar option: bran flakes. With about five grams of fiber per serving, this type of cereal contains 19 grams of net carbs per 3/4th cup serving, making it lower in carbohydrates than many breakfast cereals.

A bonus: The added fiber is beneficial to digestive health, heart health and weight management.

Berries are delicious and also low in sugar.

Viktoryia Vinnikava | Twenty20

Many people with diabetes are told they should avoid fruit. But there's often no reason to eliminate entire food groups, especially something as nutritious and tasty as fruit.

I always go for fruits low in sugar, such as berries, kiwi, melon and citrus. Watermelon is great, too, if consumed in moderation. One cup of diced watermelon has less than 10 grams of sugar.

If you want to eat fruits that are higher in sugar like bananas or mangos, enjoy them with a source of protein, like peanut butter, cheese or plain yogurt.

Mary Ellen Phipps is a registered dietitian, nutritionist and founder ofMilk and Honey Nutrition. She is also the author of "The Easy Diabetes Desserts Cookbook: Blood Sugar-Friendly Versions of Your Favorite Treats," and a writer forHealthDay. Follow her onTikTokandInstagram.

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Diabetes and the gut: How a bacterial protein may impact insulin – Medical News Today

October 15th, 2022 1:41 am

Diabetes is characterized by insufficient production of insulin due to the loss or dysfunction of pancreatic beta cells.

A new study published in Cell Metabolism shows that a protein called beta cell expansion factor A (BefA) secreted by gut bacteria could induce the replication of insulin-producing beta cells in neonatal mice.

Understanding the mechanisms underlying the actions of BefA protein could help develop therapies to stimulate beta cell proliferation in individuals with diabetes.

The study also provides a potential explanation of how the gut microbiome could play a role in the development of diabetes.

Study author Dr. Karen Guillemin, a professor at the University of Oregon in Eugene, told Medical News Today:

[Our findings imply] that the activities of gut bacteria in young animals including possibly humans can shape the development of the pancreas in early life. This is important because early life corresponding to about the first 2 years of life in a human is when insulin-producing beta cells are most proliferative, after which they become more quiescent. If this population of beta cells does not proliferate enough during early life, it means that the individual with a small beta cell pool is more vulnerable to developing type 1 diabetes if beta cells are depleted by autoimmune attack.

Dr. Martin Blaser, a professor in the Departments of Medicine and Pathology and Laboratory Medicine at Rutgers University, NJ, commented that this study is exciting because it represents a novel way that we might be able to regrow beta cells in situations with injury like type 1 diabetes.

This is a great example of how basic research on the microbiome of zebrafish can lead to new approaches to treating important human diseases, he added.

Individuals with type 1 diabetes are unable to regulate blood sugar levels due to the loss of insulin-producing beta cells in the pancreas. The loss of beta cells in type 1 diabetes is caused by an autoimmune response against these cells.

In contrast, in type 2 diabetes the body is initially able to produce insulin but the cells in the body do not respond to insulin. In response to the consequent increase in blood glucose levels, beta cells produce more insulin to compensate for the resistance of cells to the hormone. This leads to the exhaustion of beta cells and their dysfunction, resulting in lower insulin levels.

The replication rate of beta cells is high immediately after birth but rapidly declines thereafter. Thus, therapies that stimulate the replication or regeneration of beta cells in adults could help treat diabetes.

The studys authors had previously identified such a protein, called BefA, secreted by gut microbes that could stimulate the proliferation of beta cells in zebrafish.

Moreover, the authors had also identified a version of the BefA protein synthesized by gut bacteria in humans that could stimulate the proliferation of beta cells in zebrafish. In other words, the BefA proteins secreted by gut microbes in humans and zebrafish share a similar structure and function.

In the present study, the researchers further examined the mechanism through which BefA could facilitate the proliferation of pancreatic beta cells in young mice and zebrafish.

Previous studies have shown that the gut microbiome could potentially play a role in the development of diabetes. In their previous work, the study authors had shown that germ-free zebrafish larvae, which show a complete absence of gut microbes, show lower levels of pancreatic beta cell proliferation during development.

In addition, exposure to BefA prevented this decline in beta cell proliferation in germ-free zebrafish larvae.

In the current study, the researchers examined whether the BefA protein performed a similar function in mice. Specifically, they examined the impact of BefA in germ-free and specific pathogen-free (SPF) mice.

SPF mice are reared so that they are not exposed to disease-causing microorganisms that may interfere with the goals of the study.

Similar to germ-free zebrafish larvae, germ-free neonatal mice and SPF mice treated with antibodies at birth showed lower levels of beta cells than untreated SPF.

Notably, the BefA protein was able to rescue beta cell development in germ-free and antibody-treated SPF neonatal mice. Moreover, mice treated with BefA also showed lower blood glucose levels than untreated animals.

The researchers then examined whether the BefA protein could directly interact with beta cells to stimulate their expansion instead of exerting these effects by interacting with other tissues. They cultured pancreatic tissue dissected from germ-free zebrafish larvae and mice pups in the laboratory and exposed the cells to the BefA protein.

The researchers found that the BefA protein was able to directly interact with and stimulate the proliferation of pancreatic beta cells.

In subsequent studies using zebrafish larvae, the researchers examined how BefA protein synthesized by gut microbes could reach the beta cells in the pancreas. The BefA protein could be transmitted to the pancreas via the bloodstream or the hepatopancreatic duct, which connects the pancreas to the gut.

Using zebrafish models with a compromised hepatopancreatic duct or lacking blood vessels, the researchers found that pancreatic beta cell proliferation was reduced in both models.

These results show that BefA protein produced by intestinal microbiota could indeed travel from the intestine via the hepatopancreatic duct or blood vessels to reach the pancreas.

To better understand the function of the BefA protein, the researchers examined the structure of the protein. They found that BefA proteins derived from the bacterial species Klebsiella aerogenes in the human gut, and Aeromonas veronii in zebrafish showed considerable structural differences but shared an identical domain or region of the protein called SYLF.

The researchers found that the SYLF domain could rescue the loss of pancreatic beta cells in germ-free zebrafish larvae. These results suggest that this region could underlie the ability of the BefA protein to induce the proliferation of pancreatic cells.

Evidence from previous studies examining other proteins containing the SYLF domain from a wide range of organisms suggested that the ability of the BefA protein to stimulate beta cell proliferation may be mediated by its interaction with lipid membranes that surround cells.

Consistent with this, the researchers found that the BefA protein was able to permeabilize or disrupt synthetic membranes as well as membranes surrounding the cells of bacteria.

The secretion of BefA protein by certain gut bacteria could damage the cell membrane of other gut bacteria and confer a competitive advantage over these microbes. Moreover, this ability to disrupt cell membranes could also potentially explain the BefA proteins ability to enhance beta cell proliferation.

To test this hypothesis, the researchers exposed cultured pancreatic beta cells to a mutated form of BefA protein with a reduced ability to permeabilize membranes. The mutated BefA protein had a reduced ability to induce the proliferation of cultured pancreatic beta cells from neonatal mice.

These results suggest that the membrane permeabilizing activity of BefA was responsible for mediating its effects on beta cell proliferation. Proteins such as BefA may be secreted by gut microbes to gain a competitive advantage over other bacteria, but could also confer incidental benefits to the human host by facilitating normal pancreatic development.

However, Dr. Guillemin noted: We dont know yet whether BefA can stimulate proliferation of beta cells in older animals, in animals that have experienced beta cell autoimmune attack, or in people, but these are questions we are currently pursuing. We also dont know yet how membrane permeabilization stimulates beta cells to proliferate, but we are also pursuing this question.

In addition to the BefA protein synthesized by a subset of gut microbes, other proteins produced by human cells also possess membrane permeabilizing properties. This includes antimicrobial proteins that form pores in the membrane of bacterial cells and protect the body from harmful bacteria.

The researchers found that the Reg3 protein, a member of the antimicrobial protein family, was also able to increase the proliferation of mice and zebrafish pancreatic cells.

Proteins such as BefA that are produced during microbial competition are known to activate antimicrobial proteins. The study authors think that proteins secreted by gut microbes such as BefA and the antimicrobial proteins that are produced in response to these proteins could play an important role in the development of pancreatic beta cells.

These findings could facilitate the development of strategies for the prevention or treatment of diabetes. The diversification of the microbial communities in the gut occurs at the same time as the proliferation of beta cells after birth.

A lack of microbial diversity during early childhood, especially lower levels of microbes that secrete proteins such as BefA, could thus increase the risk of type 1 diabetes.

Dr. Guillemin explained:

There are several potential future therapeutic applications of our findings. One area is in prevention. It may be possible to perform microbiome profiling combined with other genetic and environmental data analysis to predict whether infants are at high risk for developing type 1 diabetes and if they may benefit from prophylactic administration of BefA-producing gut bacteria or BefA protein formulations to stimulate the development of their beta cell population in the first 2 years of life, which is when beta cells are most proliferative and when the lifelong pool of beta cells is established.

The second area is in the treatment of [type 1 diabetes], she added. It is possible that BefA will prove useful for stimulating the proliferation of beta cells in older individuals and in pancreases following the autoimmune destruction of beta cells, which is the process that causes [type 1 diabetes].

Even if BefA itself is not able to stimulate beta cell proliferation in these circumstances, our studies of the BefA mechanism may uncover new strategies to stimulate beta cell proliferation through membrane manipulations, said Dr. Guillemin.

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Diabetes and the gut: How a bacterial protein may impact insulin - Medical News Today

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