StemCell Therapy

BASKING RIDGE, N.J., Sept. 11, 2020 (GLOBE NEWSWIRE) -- electroCore, Inc.(Nasdaq: ECOR), a commercial-stage bioelectronic medicine company, today announced that management is scheduled to present at the HC Wainwright Virtual 22nd Annual Global Investment Conference, which is being held from September 14-16, 2020.

Presentation details:

Date: Wednesday, September 16, 2020Time: 1:30-1:50pm EDT

A live webcast of the presentation will be available on the Investors section of the company's website:www.electrocore.com

About electroCore, Inc.

electroCore, Inc. is a commercial stage bioelectronic medicine company dedicated to improving patient outcomes through its platform non-invasive vagus nerve stimulation therapy initially focused on the treatment of multiple conditions in neurology. The companys current indications are the preventative treatment of cluster headache and migraine and acute treatment of migraine and episodic cluster headache.

For more information, visit:www.electrocore.com

Investors:Hans VitzthumLifeSci Advisors617-430-7578hans@lifesciadvisors.com

or

Media Contact:Jackie DorskyelectroCore973-290-0097

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electroCore to Present at the HC Wainwright Virtual 22nd Annual Global Investment Conference - Yahoo Finance

ASPEN It isnt noticeable at first. It starts with changes for which the brain can compensate, meaning no real impact on day-to-day functions or cognition.

But as time passes, the brain can no longer compensate for the damage its experiencing. Subtle problems with memory and thinking begin to pop up. Subtle turns to noticeable. Noticeable turns to difficulty carrying out everyday activities. Eventually, around-the-clock care is required.

This is the broad view progression from preclinical to severe Alzheimers disease, a degenerative brain disease that becomes worse with time and age, and is the most common cause of dementia, according to the Alzheimers Association.

In Colorado, an estimated 76,000 people are living with Alzheimers dementia, and that number is expected to increase 21% to 92,000 by 2025, a 2020 Alzheimers Association report states. As of July 2019, 14.6% of Coloradans, or about 840,000 people, were 65 or older, U.S. Census Bureau data shows.

While its been shown that living in higher elevation communities can lead to a more active, healthier lifestyle and even prolonged life, its less clear how living at high elevation correlates with degenerative brain diseases.

In short, the answer is complicated and not well researched.

As far as I know, there isnt a lot of evidence one way or another about high altitudes versus low altitudes for Alzheimers disease risk, said Dr. Huntington Potter, director of the Alzheimers and Cognition Center at the University of Colorado Anschutz Medical Campus. We cant say one way or another whether high altitude is a risk factor for Alzheimers.

At the Alzheimers and Cognition Center, which is part of the CU Anschutz Medical Campus and School of Medicine, clinicians and researchers are dedicated to discovering effective early diagnostics, preventions, treatments and ultimately cures for Alzheimers disease and related neurodegenerative disorders, according to its website.

For Potter, that means looking at biomarkers or diagnostic proteins in the blood that can help clinicians predict the disease earlier, conducting projects that look at the lifespan of people with Alzheimers disease, and other research that can quickly be translated to better care, treatment and hopefully a cure.

Right now, the center is studying a drug called Leukine, which preliminary data shows might improve Alzheimers disease in the short term, Potter explained. The center also is studying other drugs that attack the disease.

Leukine may be the first one we found that looks promising, but we have several coming up that look promising, as well, Potter said.

When it comes to looking at the potential correlation between living at high elevation and the risk for dementia-inducing diseases, Potter and Dr. Peter Pressman of the Alzheimers and Cognition Center said it would take great effort, time and funding to research.

Assistant professor for the Department of Neurology, Dr. Peter S. Pressman works in his office at the University of Colorados Anschutz Medical Campus in Aurora on Thursday, Sept. 10. Photo by Liz Copan / Studio Copan

Assistant professor for the Department of Neurology, Dr. Peter S. Pressman is pictured outside his office building at the University of Colorados Anschutz Medical Campus in Aurora on Thursday, Sept. 10.Photo by Liz Copan / Studio Copan

Assistant professor for the Department of Neurology, Dr. Peter S. Pressman works in his office at the University of Colorados Anschutz Medical Campus in Aurora on Thursday, Sept. 10. Photo by Liz Copan / Studio Copan

Assistant professor for the Department of Neurology, Dr. Peter S. Pressman works in his office at the University of Colorados Anschutz Medical Campus in Aurora on Thursday, Sept. 10. Photo by Liz Copan / Studio Copan

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Pressman, who is a behavioral neurologist and researcher with the center, said on top of securing and carefully selecting a large group of people living at elevation to participate in a study, researchers also would have to follow that group for about a decade to get meaningful results.

Its easy to fund a study for a few years, Pressman said. People give you money to do something for two to three years, but two to three years is not enough time for a process as slow as Alzheimers and dementia to really even pick up. Im not saying thats not possible. Its doable, but it would take some effort.

Dr. Brooke Allen, neurologist, founder of Roaring Fork Neurology in Basalt and medical director at Renew Roaring Fork, an assisted living and memory care center in Glenwood Springs, expressed similar thoughts.

As a part of any mild cognitive impairment or dementia evaluation, Allen said her team checks the oxygen level a patient has and considers the elevation at which that person spends most of their time.

Lower oxygen levels can contribute to people experiencing confusion, dizziness and mild short-term memory issues. But outside of looking at oxygen levels and how they could be contributing to symptoms, Allen said she doesnt consider elevation a higher risk situation.

Allen said she feels High Country residents 65 and older tend to be much younger than their age in terms of their lifestyle, which is a positive in terms of dementia prevention.

About four years ago, Allen and her team conducted a long-term preclinical Alzheimers trial as part of the Alzheimers Prevention Initiatives Generation Program, a study that looked at the effectiveness of preventative treatments for individuals between 65 and 75 who had no symptoms of dementia.

Allen said more than 250 people came in to participate in the study and all generally led healthy, active lifestyles.

I think in our valley, Ive experienced meeting those kinds of people and not thinking of altitude as a risk factor but as a lifestyle opportunity in a rural area like ours, Allen said about the people who participated in the study.

Looking at the potential correlation between living at high elevation and risk of degenerative brain diseases is not just a difficult feat for Colorado researchers. Little research with concrete findings exists nationally or globally.

One study published in 2015 by Dr. Stephen Thielke in JAMA Psychiatry looked at deaths attributed to Alzheimers dementia reported in 58 counties in California to try to determine whether rates of dementia were associated with average elevation of residence. The study found that the counties at higher elevation generally had lower rates of dementia mortality.

Additional work is needed to determine whether this relationship holds in other populations, the study notes.

But beyond this study, there isnt much conclusive evidence for or against a correlation, as emphasized by Dr. Brent Kious, a psychiatrist, assistant professor and researcher with University of Utah Health and the schools Department of Psychiatry.

Kious has studied the link between living at high elevations and major depressive disorder, anxiety and suicide, and he said he and his research team have been interested in the impact of elevation on the incidence and median age of onset of Parkinsons disease.

However, Kious said decrements in cognitive performance due to chronic exposure to moderately high elevation might not necessarily translate into an increased risk of dementia.

It is not clear whether altitude would affect those neurodegenerative processes or not, though there is some reason to think that they involve oxidative damage so relative hypoxia might slow them, Kious wrote in an email. He went on to note that relative and prolonged hypoxia, or a lack of oxygen, has been associated with dementia risk. In any case, a good epidemiological study of the association between altitude and dementia should control for things that might be associated with both.

Karen Eck, 60, of Silverthorne, picks tomatoes at the Timberline Adult Day Program garden in Frisco on Thursday, Sept. 10. Eck, who was diagnosed with early onset Alzheimers, attends programs three to four times a week at the center.Photo by Jason Connolly / Jason Connolly Photography

Karen Eck, 60, of Silverthorne, waters tomatoes at the Timberline Adult Day Program garden in Frisco on Thursday, Sept. 10. Eck, who was diagnosed with early onset Alzheimers, attends programs three to four times a week at the center.Photo by Jason Connolly / Jason Connolly Photography

Karen Eck, 60, of Silverthorne, poses for a portrait at the Timberline Adult Day Program garden in Frisco on Thursday, Sept. 10. Eck, who was diagnosed with early onset Alzheimers, attends programs three to four times a week at the center.Photo by Jason Connolly / Jason Connolly Photography

Karen Eck, 60, of Silverthorne, enters the Timberline Adult Day Program in Frisco on Thursday, Sept. 10. Eck has early onset Alzheimers.Photo by Jason Connolly / Jason Connolly Photography

Karen Eck, 60, of Silverthorne, leaves the Timberline Adult Day Program garden in Frisco after watering tomatoes on Thursday, Sept. 10. Jason ConnollyPhoto by Jason Connolly / Jason Connolly Photography

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While theres not good data for or against high elevation as a risk factor for degenerative brain diseases, there is evidence that people living in more rural communities do not have the same access to dementia care and treatment as those living in urban areas.

According to the 2020 Snapshot of Rural Health in Colorado, produced by the Colorado Rural Health Center, 721,500 people are living in rural Colorado and 19% of the rural population is age 65 or older. Rural is defined as a nonmetropolitan county with no cities over 50,000 residents.

Chad Federwitz a gerontologist, or specialist in the study of aging, and manager of Pitkin County senior services said he hasnt seen any correlation between living at high elevation and dementia risk. Anecdotally, he does know that people move to Grand Junction or the Front Range if they have dementia because of a lack of care resources in the High Country.

Given the nature of our rural-ish community, we dont have the same resources, Federwitz said, referring to things like long-term assisted living and memory care options. You can go to Grand Junction or the Front Range and have pages and pages of resources as opposed to here.

While there are some dementia care resources in more rural Colorado communities, the Alzheimers and Cognition Center is working to do more to develop meaningful relationships with health care providers and dementia patients in the states mountain communities as part of its mission.

According to Pressman, who is heading this charge on behalf of the CU center, a lot of projects are in the planning stages but include virtually educating medical providers, nurse practitioners and primary care doctors on Alzheimers and general healthy brain aging as well as mutual, participatory research with rural Colorado communities and communities of color.

Pressman explained that a lot of research related to Alzheimers overwhelmingly is based on middle-class, well-educated, white participants. And so while researchers think they know a lot about the disease in general, they really only know about the disease related to this demographic group.

Through the centers outreach and efforts to better connect with underrepresented communities, Pressman hopes to conduct better science and better serve the larger Colorado community.

What motivates me is trying to do good work, trying to do good science and to make sure our results actually represent real life, Pressman said. We want to make sure were helping everybody, not just a niche group, and that our services are available equitably to as many people as possible.

Editors note: This is Part 2 of a four-part series on longevity in the High Country. The series is being produced in partnership with The Aspen Times, Glenwood Springs Post Independent, Steamboat Pilot & Today and Vail Daily. Read more at SummitDaily.com/longevity.

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The aging brain: Exploring the connection between neurology and elevation - Summit Daily News

Were healthier and live longer than our ancestors, yet were constantly reminded of deaths caused by war, terrorism and natural disasters. As terrible as these events are, they accounted for less than 1% of the 56 million worldwide deaths in 2017.

Another colossal distraction is the focus on lifestyle as a way to better peoples health and reduce health inequalities. Of course, what people eat, how much they exercise, whether they smoke and how much alcohol they drink have a bearing on their health. But what matters much more is the circumstances in which people are born, live, work and age the social determinants of health.

The fact that the environment shapes peoples lives and health has been known for a long time. In 1842, Edwin Chadwicks Report on the Sanitary Condition of the Labouring Population of Great Britain highlighted how the ill health of the poor was not the result of their idleness but of their terrible living conditions.

In his semi-autobiographical novel The Ragged Trousered Philanthropists, written over a century ago, Robert Tressell explained how the poor health of the hero of the book, impoverished painter and decorator Frank Owen, could not be solved by medicine alone. It was social medicine that he needed:

The medicine they prescribed [Frank Owen] and which he had to buy did him no good, for the truth was that it was not medicine that he like thousands of others needed, but proper conditions of life and proper food.

And over 70 years ago, Sir William Beveridge, the architect of the British welfare state, called for action to tackle the root causes of poor health: poverty, low education, unemployment, poor housing and other public health issues, such as malnutrition and inadequate healthcare.

There is no denying that great progress has been made since the work of Chadwick, Tressell and Beveridge. Far fewer people in the UK experience the absolute poverty, squalor and overcrowding they described.

But the fact remains: the profound health inequalities between rich and poor that have been highlighted throughout the past century most notably in the Black Report, which was published 40 years ago remain today. In 2020, a baby boy born in wealthy Kensington, London, can expect to live over ten years longer and nearly 20 more years in good health than a baby boy born in relatively deprived Kensington, Liverpool.

Today, a proportion of children still live in absolute poverty. They lack sufficient nutritious food and their families rely on food charity. They dont have a stable, decent home and are exposed to damp, excess cold, and dangerous levels of carbon monoxide. The proportion of people sleeping rough is also rising.

Beveridge saw employment as the solution to poverty, yet the number of people in in-work poverty is close to 4 million, and a growing number of jobs are part time, low paid or temporary.

The solution to poor health is to prevent it from happening in the first place. But rather than taking a preventative approach and fostering healthy lives through bettering the environments and conditions in which people live, national health services, such as the UKs NHS, are primarily set up to treat the symptoms of poor health.

Essentially, the UK has a National Disease Service. Its an incredibly good one, but the primary drive should be to prevent these expensive-to-treat chronic health conditions arising in the first place. Unfortunately, the big loss in public-health grant funding for local councils in the UK in recent years is testament to the governments continued focus on treatment.

The public health education campaigns that do exist encourage people to move more, eat healthier and limit alcohol consumption. They disregard underlying economic factors and neglect the fact that many people simply dont have the same opportunities or resources to be as healthy as others do.

The economic basis of poor health is all too relevant today given the increasing return of diseases of poverty and the emergence of devastating new epidemics such as COVID-19.

The reality is that peoples health choices are heavily influenced by the conditions in which they live. Whether they have a job thats safe, secure and decently paid, and one that gives them control, flexibility and meaning. Whether theyre able to afford a well-heated, well-lit, stable home in a safe area. Whether they have the money, time and resources to buy and cook healthy food and have an active lifestyle. Whether they have a walkable community that provides access to green space and essential services.

Lifestyle is also important for health, but lifestyle behaviours have causes and these causes have causes, too. Its these wider determinants of health that affect our health most.

That the most deprived areas experience almost ten times as many child pedestrian fatalities than the least deprived areas is a fitting example of how still to this day where you live can kill you.

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We've known for over a century that our environment shapes our health, so why are we still blaming unhealthy lifestyles? - The Conversation UK

Masks have become commonplace for most Americans venturing out in public as the coronavirus pandemic has dragged on for several months.

Face coverings have proven to be a key preventative measure for slowing the transmission of COVID-19 as the world waits for a safe and effective vaccine.

Our country is in a historic fight. Add Changing America to yourFacebookorTwitterfeed to stay on top of the news.

But a new paper argues there may be an additional benefit.

Monica Gandhi and George Rutherford from the University of California, San Francisco theorize in commentary published in The New England Journal of Medicine that mask-wearing could also significantly reduce the severity of the disease in those who become infected and ensure a greater number of infections are asymptomatic.

Studies show masks do not filter all airborne droplets, and its still possible for the virus to sneak through and infect the wearer.

But the ideabehind the theory is that masks can block a significant number of coronavirus droplets, lowering the dose of the virus a person inhales and reducing the chances the person will experience serious illness.

An immune response could also potentially be triggered in the mask-wearer with a small amount of virus.

SARS-CoV-2 has the protean ability to cause myriad clinical manifestations, ranging from a complete lack of symptoms to pneumonia, acute respiratory distress syndrome, and death. Recent virologic, epidemiologic, and ecologic data have led to the hypothesis that facial masking may also reduce the severity of disease among people who do become infected, the paper said.

If this hypothesis is borne out, universal masking could become a form of variolation that would generate immunity and thereby slow the spread of the virus in the United States and elsewhere, as we await a vaccine, researchers wrote.

Researchers cited several examples of masks leading to less severe outcomes in infections.

A study involving hamsters showed those living in mask-shrouded cages were less likely to be infected and showed fewer symptoms compared with unmasked hamsters, researchers said.

An outbreak on a closed Argentinian cruise ship where passengers were provided with surgical masks and staff with N95 masks resulted in 81 percent of infected passengers never developing symptoms. Thats compared to the coronavirus outbreak on the Diamond Princess cruise ship outside of China where only 18 percent of the passengers infected were asymptomatic.

During two outbreaks at U.S. food-processing plants where all workers were issued masks each day and were required to wear them, 95 percent of those who tested positive were asymptomatic while 5 percent experienced mild symptoms, the researchers noted.

Researchers noted further studies comparing the rate of asymptomatic infection in areas with and without universal mask-wearing are needed.

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Wearing a mask could reduce COVID-19 severity, researchers say | TheHill - The Hill

David L. Ryan/Globe Staff At the Mather Elementary School in Dorchester, letters A and B on desks are for students to alternate on separate days during the week to keep a social distance.

Boston officials and the teachers union unveiled plans on Thursday to randomly test teachers and other educators on a weekly basis for COVID-19, making the citys school system one of the first in the state to commit to routine testing.

Under the plan, the district will test up to 5 percent of the members of the Boston Teachers Union on a weekly basis, giving high priority to those working in schools in neighborhoods with high COVID-19 positivity rates as well as employees who work directly with students where social distancing is not possible, such as those providing hands-on support for some students with profound disabilities.

The move part of a broader agreement with the Boston Teachers Union on reopening schools that was announced Thursday comes as the city has been grappling with wide variations in coronavirus cases among its neighborhoods. Of particular concern is East Boston, which has the highest weekly positivity rate, 8.7 percent.

If East Boston were its own school system, state guidelines would strongly recommend keeping classrooms closed because its positivity rate is so high. However, Bostons overall weekly positivity rate is 1.7 percent, according to the most recent city data, enabling the districts classrooms to reopen.

Boston will begin online classes citywide on Sept. 21 and then gradually bring students back into classrooms in waves, starting in October with the highest-need students, including those with profound disabilities and those who do not know English.

Mayor Martin J. Walsh announced the union agreement as part of his routine briefings on the citys virus efforts. He highlighted the provision about the routine COVID-19 testing of union employees and other measures in the agreement such as additional training for educators on how to teach remotely and the ability to bring their own children to school if they cant secure child care.

The focus of this framework is ensuring the safety of everyone in our schools, Walsh said.

Jessica Tang, president of the Boston Teachers Union, described the testing program as a good first step, but said she would like to see more wide-scale testing of staff. She noted educators report to their schools from across the city and the region while students also criss-cross the city to get to their schools many relying on public transit creating ripe conditions for a widespread outbreak.

If we are focusing efforts on places with highest risk of infection, hopefully it will help prevent or limit spread, Tang said.

She said she would like the district to administer rapid testing for educators exhibiting symptoms to determine whether they have been infected or are instead suffering from the flu, allergies, or something else. Tang said the move would decrease potentially unnecessary quarantines that would keep teachers away from their students.

Boston appears to be one of just a handful of districts in the state that is planning to test teachers.

Cambridges school committee made routine testing for teachers a condition of reopening school buildings for students next month. The city is finalizing plans with the Cambridge-based Broad Institute to offer a testing program for all staff who will work in school buildings, said Lyndsay P. Brown, chief strategy officer for Cambridge Public Schools. The plan will not have to be approved by the school committee, said Brown.

Wellesley and Hanover plan to test staff before they enter schools, according to union agreements with the districts. Wellesley will also provide free testing once a week for staff for preventative monitoring. Watertown, Everett, Revere, and Lexington are also planning to offer at least some testing to school staff, according to the Massachusetts Teachers Association.

Debate over whether to routinely test educators has been unfolding over the summer as districts prepare to reopen schools. It intensified after Governor Charlie Baker announced plans to dispatch mobile COVID-19 testing units to schools experiencing potential clusters of cases. Teachers unions criticized the move as too reactive as they pressed for wide-scale free testing of teachers and students as a preventative measure.

The Massachusetts Department of Elementary and Secondary Education, however, has not issued any guidelines on routine testing, while the Centers for Disease Control and Prevention doesnt recommend universal testing for asymptomatic school employees and students.

In its guidance, the CDC said it is not known if testing in school settings provides any additional reduction in person-to-person transmission of the virus beyond what would be expected with implementation of other infection preventive measures, such as social distancing, mask wearing, hand washing, and enhanced cleaning procedures.

The guidance also says universal testing could present some challenges, including whether all students, parents, and staff would be receptive to the idea.

But Joshua Barocas, an infectious disease physician at Boston Medical Center and a faculty member at Boston University School of Medicine, said there can be value in doing sample testing if it is part of a broader COVID-19 prevention plan. He compared it to the kind of surveillance and population testing occurring in nursing homes, shelters, and other congregate settings, which aim to test between 20 to 40 percent of people every two or four weeks.

It can be effective at recognizing an outbreak early, said Barocas, but it also can lead to the need for further investigation and testing. Im hopeful if someone sees a possible signal of an outbreak . . . that they would increase testing to determine if its actually a signal or just noise.

He said going with a sampling of 5 percent of union members each week is a good starting point and from there the district could assess whether its large enough to be effective in either spotting potential outbreaks or instilling confidence among educators, students, and parents that they will be safe.

At 5 percent, the testing program is a potentially ambitious effort for the BPS, and could mean testing up to approximately 375 educators a week or 1,500 over the course of a month, according to Globe calculations. The Boston Teachers Union has about 7,500 active members, including nurses, classroom aides, and guidance counselors across 125 buildings.

But not all union members would be eligible for testing. The agreement limits testing to only those who report to school buildings with students inside. Members can only be tested every 14 days. Results would be available within 24 to 48 hours.

The district will provide weekly public reports on incidents of infection by school, according to the agreement.

Many details of the testing program are still being worked out with the Boston Public Health Commission, a school spokesman said Thursday night. The school system also had no estimated cost for the program and did not say where the money would come from to cover the testing.

Thomas Scott, executive director for the Massachusetts Association of School Superintendents, said he has mixed feelings about routine testing, especially the cost and the possibility of false positives for employees with no symptoms.

Having regular testing probably has some value," he said, but he added, "I dont know if it will make a difference for districts in preventing transmissions.

Beth Kontos, president of the American Federation of Teachers Massachusetts, which Boston teachers belong to, said she views the BPS COVID-19 testing as a win for public health. But she wishes the state would create a routine testing program for all districts instead of just providing emergency testing.

Its a shame we have to wait for people to get sick until we do the right thing, she said.

Felicia Gans and Naomi Martin of the Globe staff contributed to this report.

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Boston to randomly test teachers and other educators weekly for COVID-19 - msnNOW

Despite not being able to attend conferences live, there are some advantages to a virtual conference.

Personalized medicine might be a realistic target in many specialties in the next decade, including pulmonology.

Recently, in a paper presented at theEuropean Respiratory Society International Congress 2020 (ERS 2020), researchers presented data showing adiponectin and leptin were significantly different between men and women, with higher levels found in female patients.

Lars L. Andersson, PhD, Karolinska Institute, said 1 of the objectives of the study was to get closer to personalized medicine in an effort to derive what treatments could be most effective in individual patients.

Andersson explained in an interview with HCPLive, the new study gives researchers a better understanding of the impact of sex and age on circulating adipokines.

The study included 55 patients with mild to moderate asthma, 72 patients with severe asthma, and 41 patients with COPD. Overall, the researchers found both adiponectin and leptin were highly affected by body mass index (BMI), another datapoint for personalized medicine.

In a subgroup analysis, they found the difference in adiponectin between women and men was smaller in lean patients, while the difference in leptin was smaller in obese patients.

While the study was important, in a normal year Andersson would be able to present it live to his colleagues. However, with the coronavirus disease 2019 (COVID-19) pandemic bringing conferences virtual Andersson was forced to adjust.

However, Andersson said the virtual format has some benefits.

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Lars Andersson, PhD: The Future of Personalized Medicine for Asthma - MD Magazine

The proteomics market is segmented on the basis of proteomics instrumentation technology such as protein microarray (biochips, microarray instruments), spectroscopy (Mass and NMR), X-ray crystallography, chromatography, electrophoresis, proteomics reagents, proteomics services (analytical lab services, protein identification, extraction, sequencing, data analysis, maintaining bioinformatics data bases). The market is driven by growing need of personalized medicines, new discoveries in the field of genomics, rise in funds for proteomics based research, growing research and development expenditure, advancement in technologies, new techniques, high output, high resolutions achiness and instruments have been developed, availability of private funds and rise in the Asian markets like China and Japan.

The Final Report will cover the impact analysis of COVID-19 on this industry (Global and Regional Market).

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The top 10 companies own 40 to 50 percent of the market. Proteomic instrumentation market is dominated by proteomic microarray, accounting for around 50% of the revenue followed by spectroscopy techniques. Proteomic reagents market is dominated by immunoassays.

The market is restrained by various factors such as: success ratio of the researches is not very high, limitations of personalized medicines and lengthy regulatory approval process, reduction in funds by the US government, which owes 40% of this market, highly expensive medicines, which are 1000 fold costlier than the normal medicines present in the market and research and market is limited to a few developed nations only.

Major opportunities for the market lie in the Asian markets where contract research organizations are on a rise. Proteomics is science with broad applications in the field of therapeutics and diagnostics. Growing R&D and emergence of new players will create more market opportunities. Major players in the proteomics market are Thermo Fischer scientific corporation, Agilent technologies, Luminex corporation, Sigma-Aldrich corporation, Danaher corporation, Bio-Rad corporation, Waters corporation, PerkinElmer, Affymetrix and others.

The Final Report will cover the impact analysis of COVID-19 on this industry (Global and Regional Market).

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Companies profiled

1. Genzyme Corporation2. Thermo Fischer scientific corporation3. Becton Dickinson and Co4. BG medicine5. Agilent technologies6. Luminex corporation7. Sigma-Aldrich corporation8. Danaher corporation9. Anaspec Inc10. Asterand PLC11. Applied biosystems Inc12. Bayer technology13. Bio-Rad corporation14. Waters corporation15. PerkinElmer16. Affymetrix17. GE healthcare18. Genesystems Inc19. Activx Biosciences Inc20. Amgen Inc21. Beckman coulter22. Biacore International AB23. Biocarta Inc24. Bruker biosciences25. Caliper Lifesciences26. Cellzome AG27. Commonwealth biotechnologies28. Digilab biovision GmBH29. Dionex Corp30. Dualsystems biotech AG

This Research Report covers

1. Historical data2. Revenue forecasts, growth rates and CAGR upto 20283. Industry Analysis4. Competitive Analysis5. Key geographic growth data6. In-depth profiling of companies

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Key Answers Captured in Report?

About Kenneth Research:

Kenneth Research provides market research reports to different individuals, industries, associations, and organizations with the aim of helping them to take prominent decisions. Our research library comprises more than 10,000 research reports provided by more than 15 market research publishers across different industries. Our collection of market research solutions covers both the macro level as well as micro-level categories with relevant and suitable market research titles. As a global market research reselling firm, Kenneth Research provides a significant analysis of various markets with pure business intelligence and consulting services on different industries across the globe. In addition to that, our internal research team always keeps a track of the international and domestic market for any economic changes impacting the products demand, growth, and opportunities for new and existing players.

Updated Research Report Available @Kenneth Research with impact analysis of COVID-19

Geospatial Imagery Analytics MarketNetwork Access Control MarketVisitor Management System MarketPenetration Testing MarketPower Distribution Unit (PDU) Market

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Impact Analysis of COVID-19 on Proteomics Market Outlook 2020-2028 by Emerging Global Trends, Leading Companies, Future Growth, Revenue, and Demand...

The global cell surface markers market is valued at an estimated USD 520 million in 2018 and is projected to reach USD 769 million by 2023, at a CAGR of 8.1%

Factors such as the increasing funding for life sciences research, high global prevalence of cancer, and growth in stem cell and neurobiology research are expected to drive the growth of this market in the coming years.

[140 Pages Report] The cell surface markers market is valued at an estimated USD 520 million in 2018 and is projected to reach USD 769 million by 2023, at a CAGR of 8.1% during the forecast period.

Cell Surface Markers Market by Product (Antibody, PCR Array), Source (Mice, Rat), Cell Type (T cells, B cells, NK cell), Application (Research (Stem Cell, Immunology), Clinical (Oncology, Hematology)), and End User (Hospitals) - Global Forecast to 2023

What drives the Market?

The increasing number of R&D activities and the growing use of cell surface markers in personalized medicine and drug discovery & development.

Download a PDF Brochure @ http://www.marketsandmarkets.com/pdfdown=216278622

North America is expected to be the largest regional market for cell surface markers

Market growth in North America, the largest regional market for cell surface markers, is primarily driven by the increasing number of R&D activities and the growing use of cell surface markers in personalized medicine and drug discovery & development. However, the market in Asia is estimated to grow at the highest CAGR during the forecast period.

The high growth of the Asian market can be attributed to the increasing number of life sciences research activities and government initiatives to boost the biotechnology and pharmaceutical industries in several Asian countries.

Key Market Players

The cell surface markers market is highly fragmented in nature, with several big as well as emerging players. Prominent players in this market include Thermo Fisher Scientific (US), QIAGEN N.V.

(Netherlands), Becton, Dickinson and Company (US), F. Hoffman-La Roche (Switzerland), Bio-Rad Laboratories (US), Danaher Corporation (US), Abcam (UK), GenScript (China), BioLegend (US), Cell Signaling Technology (US), Merck KGaA (Germany), and Bio-Techne (US).

Abcam is one of the prominent players operating in the cell surface markers market. The strong position of the company in this market can be attributed to its robust product portfolio.

The company has a strong geographical presence in the European and Asia Pacific markets with its manufacturing facilities in the UK, Japan, and China. The company also has significant market presence in the US and Latin America.

Thermo Fisher Scientific is another leading player in the cell surface markers market. The companys strong brand recognition and extensive product portfolio in this market are its key strengths.

To maintain its leading position in the market, the company adopts organic as well as inorganic growth strategies such as acquisitions and expansions.

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North America is expected to be the largest regional market for Cell Surface Markers - WhaTech

Global microbiome sequencing marketis expected to rise to an estimated value of USD 3455.33 million by 2026, registering a healthy CAGR in the forecast period of 2019-2026. This rise in market value can be attributed to the focus of various researchers on utilization of this technology in the development of personalized medicine and dietary applications.

For the growth of any business, Microbiome Sequencing market research report plays a very important role. You can get an in-depth market analysis with this report to thrive in this competitive environment. Microbiome Sequencing market report is sure to lend a hand in enhancing sales and improving return on investment (ROI). Estimations of CAGR values, market drivers and market restraints helps businesses decide upon several strategies. DBMR team provides you the Microbiome Sequencing market research report with commitment that is promising and the way in which you anticipate. As it is a third-party report, Microbiome Sequencing report is more unprejudiced and hence provides a better picture of what is really happening in the market.

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Few of the major competitors currently working in the global microbiome sequencing market areBIOLOG; Cosmosid Inc; Illumina, Inc.; Metabiomics Corp.; Oxford Nanopore Technologies; BaseClear B.V.; BGI; BioMathematica; Charles River; CoreBiome, Inc.; Clinical-Microbiomics A/S; Diversigen; Eurofins Scientific; LABCYTE INC.; Leucine Rich Bio Pvt Ltd.; Microbiome Insights; MICROBIOME THERAPEUTICS, LLC; Thermo Fisher Scientific Inc.; Molzym GmbH & Co. KG; Norgen Biotek Corp.; Phase Genomics Inc.; QIAGEN; Resphera Biosciences, LLC; Shoreline Biome; StarSEQ GmbH; Viome, Inc.; Zymo Research among others.

Key Developments in the Market:

Market Drivers

Market Restraints

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Segmentation: Global Microbiome Sequencing Market

By Sequencing Technology

By Component

By Targeted Disease

By Application

By Research Type

By End-User

By Laboratory Type

ByGeography

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Global Microbiome Sequencing Market By 2027 Emerging Technology, Opportunities, Analysis And Future Threats With Key Players Like Oxford Nanopore...

Neurological Biomarkers Market Research Report is a Proficient and In-Depth Study on the Existing State of Neurological Biomarkers Industry. This Report Focuses on the Major Drivers, Restraints, Opportunities and Threats for Key Players. It also Provides Granular Analysis of Market Share, Segmentation, Revenue Forecasts and Regional Analysis till 2025.

The recent study on Neurological Biomarkers market offers an all-inclusive analysis of this vertical, with emphasis on the growth driving factors as well as facets such as consumption and production. Constraints and potential threats expected to restrain the expansion along with solutions to overcome the challenges are discussed at length. Moreover, insights of the market share along with estimates reflecting the CAGRs of the listed segments are highlighted in the document.

In hindsight of the COVID-19 pandemic, the report investigates the prevalent business strategies employed by leading organizations and offers tactics for stakeholders to adapt to the industry changes over the forecast period.

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Neurological Biomarkers Market Structure, Industry Inspection, and Forecast 202 - News by aeresearch

September 06, 2020

Doug McDaniel has spent much of his life sifting through decades worth of data online, scouring old newspapers and tracking down primary sources in hopes of documenting the athletic history of Mount Airy City Schools.

McDaniels meticulous research has connected Granite City student-athletes, coaches and fans of today with those of the past century. His work began primarily in football, but has since spread to sports across the board.

In all his trips down the rabbit hole, McDaniel has unearthed some of the most successful athletes in state history that also called Mount Airy home.

The 1973 graduate of Mount Airy High thought hed discovered the best athletes from the citys history, especially in football and basketball, by now. If someone told McDaniel there was someone he missed in his research, McDaniel would be skeptical to say the least.

Never in his life was McDaniel so elated to recently learn he was wrong.

As it turns out, a world class athlete named Ted McBride sat just a few pews away from McDaniel at Fellowship Missionary Baptist Church. The two knew each other for the better part of 50 years.

McDaniel just happened to run across an old article about McBride within the past year. McDaniel considered McBride a dear friend, but he had no clue McBride possessed such an incomparable resume. It included state championships, a few All-American selections and a pair of Olympic medals.

There was no question then that McBride deserved to be known as a true legend.

I think hes the best athlete that Surry County has ever known and maybe will know, McDaniel said.

McDaniel isnt the first to believe this, either. In a 1957 article from The Mount Airy News, author Joe Griffin said the following:

When one surveys the historical annals in search of who was probably the best athlete ever to emerge from the Granite City, he can hardly overlook the performances of a young deaf athlete by the name Ted McBride.

You name it, he did it

Ted Lee McBride was born Nov. 29, 1934, to parents Benson Boss and Kate McBride.

He grew up in a big, white frame house across from the old Flat Rock High School. According to McBrides widow, Eugenia, he attended school at Flat Rock until his mother realized he was not progressing.

As a result, his mother decided the best thing to do was to send McBride to the North Carolina School for the Deaf in Morganton.

She told me, That was the hardest thing I ever had to do, to leave my son; and I couldnt go back for two weeks, Eugenia McBride said, stressing how beneficial the move was to her sons life. Ted credits that to his success. He had good parents and good teachers that influenced him a whole lot.

McBride started attending the school in 1946. Because he wasnt fluent in sign language, McBride had a lot of catching up to do in school. As a result, he didnt enter high school until 1950, just a few months shy of 16.

School officials learned very quickly they had a star in the making. Griffins article stated that McBride was tall, fast and, most importantly, humble.

You name it, he did it, Eugenia said.

McBride morphed into an all-time great in football, basketball and track.

As a tight end and defensive end, McBride helped the school record three perfect seasons in 1951, 1953 and 1954. McBride earned All-American honors in three straight seasons from 1952-54. The school had an overall record of 22-2 during that three-season span.

The schools undefeated season in 1954 was good enough to rank them third in the nation. In addition to being named an All-American for a third time, McBride was named National Player of the Year by Silent Workers, a national magazine popular with the deaf population.

McBride also served as the schools basketball center during his high school years. He led the team in rebounding for most of his high school career and was named a member of the All-American Second Team by Silent Workers.

Track and Field was the latest of McBrides sporting endeavors, picking it up in 1953. It went on to be the sport in which he experienced the most success after high school.

While at the North Carolina School for the Deaf, McBride set numerous school records in hurdles as well as the pole vault. He led the team to a national championship and was named the top individual performer in the Asheville Relays the top state event in track.

McBride captured three state championships in the Western North Carolina High School Activities Association, which didnt merge with the N.C. High School Athletic Association until 1977.

Olympic Medalist

McBride aged out of high school sports in 1955. As he finished school, McBride played basketball in an industrial league in Morganton. He led the team to a 13-2 record and was named to the all-league team.

He later represented South Carolina in the National Deaf Tournament that year. Teams from across the country convened in Washington, D.C. McBride helped South Carolina finish second in the tournament.

Graduation came in 1956. He ended up staying in Morganton to work in the maintenance department.

The completion of high school did not mark the end of McBrides athletic career. In fact, he arguably made the biggest impact after school.

The United States was tasked with assembling a team for the 1957 Deaflympics in Milan, Italy.

From Griffins article: He was so well liked and respected that, when NCSD was given an invitation to enter an athlete for competition in the Deaf Olympics [sic], Ted was the unanimous choice.

Fundraisers in both Morganton and Mount Airy helped raise the $1,200 necessary to send McBride to Italy. He was set to compete in the 110-meter hurdles and 400-meter hurdles.

McBride stood tall at the international competition just as he had at every other level.

The 110-hurdles was McBrides specialty. He finished the race in 16.2 seconds to earn the gold medal. This was 0.8 seconds faster than the previous Deaflympics world record.

Competing in the 400-hurdles was new to McBride, as schools in the states only went up to 300 meters at the time. This was the first time hed competed in such a race competitively, and he still managed to grab a medal. He earned a bronze medal with a time of 56.7 seconds, just 0.2 seconds behind the silver medalist.

McBrides two medals helped Team USA win the overall track and field event. He was featured in publications such as The New York Times and in stories by the United Press.

His athletic career slowed following the Deaflympics. McBride earned an All-District award from the National Basketball Congress of America in 1959. He was later inducted into the North Carolina School for the Deaf Athletic Hall of Fame in 1979 and then the Southeast Athletic Association of the Deaf Hall of Fame in 2012.

Ted McBride is right up there with anybody as far as greatness goes, McDaniel said. I challenge anybody to have his credentials of athletic achievement. Not just countywide, not just statewide and not just nationwidebut internationally.

He was just Ted

Given McBrides incredible athletic past, its almost unfathomable to think most people never had a clue about it.

Eugenia McBride explained her husband was always humble and more interested in other peoples lives and stories. In fact, she said when they got married all of his medals and awards were in a shoebox in the trunk of his car.

He didnt brag about this, Eugenia McBride said. He was just Ted; a Mount Airy boy. If someone asked, he would tell you about it, but he never brought it up. Thats about the only way I know to describe it.

When he looked at you and he smiled I dont know how to explain it, McDaniel said. Its like a smile of caring and of love. Like saying, When Im looking at you, youre the most important person on earth.

Eugenia and Ted met through the Fellowship Missionary Baptist Church. A couple in the congregation had a daughter that was about to graduate from Ted McBrides old school and wanted to attend a church in Mount Airy that had an interpreter.

We had a missionary come to the church and God just called me, she said. I got a call to go to that alter at the end of the service to commit to learning sign language. I couldnt have done it without God.

The first teacher Eugenia McBride had left the church when she had been learning for a while, saying now was the time to immerse herself in sign language. So, she and a few women from church went to beg her future husband to teach them and he agreed.

Shortly after they began dating and eventually married in 1970.

I tell everybody I married the teacher, Eugenia said.

Together, the two had a daughter, Rebecca, that is now married to Brad Calloway. Rebecca and Brad have two children in college: Hayden and Haley.

Ted McBride went on to work at Pike Electric and was well respected as a master electrician, McDaniel said. He attended church every week he was able and always cared for his friends and family.

Eugenia McBride said that being deaf did not bother Ted, and that he didnt see it as a handicap. Rather, it was just the way life was. Whether in athletics or when raising a family, McBride worked hard and never took shortcuts. It he was going to do something, it was going to get done right, Eugenia McBride said.

I get a little emotional about Ted McBride because he was such a dear friend of ours, McDaniel said. He would kind of get you started about what youre doing and never wanted to talk about himself. He just kind of deferred everything away from him. To be more like Ted McBride is what we should all strive for.

Up here we didnt even know about his past, and down there in Morganton hes a legend. He needs to be a legend up here, and he needs to be talked about.

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County seeking broadband need response - Mount Airy News

On September 11, 2020 at about 5:07 a.m., Tara Trunfio (24), from Colorado, was arrested for Assault in the Second Degree and Resisting Arrest.

Investigation reveals that on September 11, 2020 at about 3:46 a.m., Hana Patrol officers were assigned to the 4590 Hana Highway, regarding a female with a stab wound. It was alleged that Trunfio had earlier stabbed the victim while at the end of Ulaino Road.

Trunfio was located at the very end of Uluino Road. After advisement of her Constitutional Rights and being told she was under arrest, Trunfio physically and verbally resisted. A struggle ensued. Trunfio was taken into custody and transported to the Hana Police Station. She was assessed by Medic 6. Neither Trunfio nor Officers sustained or reported any injuries as a result of this incident.

Trunfio was later transported to the Wailuku Receiving Desk for processing.

On September 11, 2020 at about 11:01 a.m., Trunfio was formally charged for Assault in the Second Degree and Resisting Arrest. Her bail is set at $7,000. As of 12:15 p.m., she remains in Police Custody.

Press Release 9-120-20 Maui Police Department

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Colorado woman arrested for Assault in the Second Degree and Resisting Arrest - Maui Time

Owning a Jersey herd that produces 8100 litres at 5.75%BF and 4.01%P (780kg fat plus protein), can prove problematic knowing where to turn to continue improving performance. But for Andrew Hastie and his family at Alderston Mains near Haddington in East Lothian, the answer has come through a marriage of focussed management, high quality genetics and up-to-date milking technology.

Having experienced success through a combination of the Viking Jersey and robotic milking during a gradual switch over the last three years, the Hasties have decided to follow this process to its logical end. This year, they will add their final two Lely Astronaut A5 robots, bringing their total to six (2 x A4 and 4 x A5), and theyll complete the switch to using genetics exclusively from the Viking countries (Sweden, Finland and Denmark).

With a modest acceptance that the herds production is nearer the top than the bottom, Mr Hastie remarks: Were not really far ahead of the average when you go to Denmark.

And therein lies the overriding reason for the familys choice of genetics, which sees the Vikings gradually take over from all other bloodlines.

The farms foundations were laid in the 1950s when grandfather, David Hastie, started the herd with native UK Jerseys. Since that time, Andrew and his parents, Gordon and Vivian, and brother, David, have fine-tuned both the farm and the herd, to reach the exceptional performance of today.

Over that period, the farm has switched from a mixed enterprise to one thats purely focussed on dairy, with all grass and arable crops across its 400 acres now grown exclusively for the 360-head herd. With a target of increasing the herd to 430 head, the plan is to consolidate numbers at this level.

Weve always enjoyed the Jersey and found her to have robustness and some health benefits over the Holstein, says Mr Hastie. We operate a sort of hybrid system where we want high yields but like the cows to go outside for exercise and grazing even with the robots as we feel its good for their health and keeps our feed costs down in summer.

Close attention has always been paid to the type of genetics that will best meet the farms targets, which began in the earliest days of the herd.

My grandfather was an early adopter of artificial insemination; hed use the best bulls he could get from the USA, New Zealand and Denmark and we continued breeding this mixture for a long time, he said.

Around 15 years ago we dropped the New Zealand bulls, largely because their genetics is driven by milk solids weight-based contracts, which are not quite like our own.

The USA we felt was at the other extreme, and our experience was that the taller, leaner and more angular animals didnt live so long.

We feel the Viking breeding programme has the balance just right, with cows which look long-lasting and producing high quality milk. They are particularly suited to our contract with Grahams Family Dairy, where we need to produce at least 5% fat for the Gold Top range.

In some past summers we had been slightly short of butterfat but find the VikingGenetics bulls are helpful in boosting that.

Around 18 months ago the farm also switched to sexed dairy semen which is now used alongside Aberdeen Angus beef.

Also opting to introduce genomic testing for heifers, Mr Hastie says this is giving an early indication of genetic potential across a range of traits.

When you have a cow on the ground you have a good idea of how she should breed, he says. But with a heifer, all you have is the animals pedigree, so a genomic test adds accuracy for many different traits.

There are also traits on the VikingGenetics bar chart which you dont normally have, he adds. This includes hoof health and saved feed index, which are helping us to breed cows with better feet and more efficiency.

We only started genomic testing recently but plan to test all 200 of our heifer calves born each year, he says. This supplies a linear bar chart, just like youd have for a bull, and you can see straight away what you need to improve.

It also ranks the heifers on the Nordic Total Merit [NTM] index, which is not unlike the UKs PLI [Profitable Lifetime Index].

Also using VikMate, the VikingGenetics mating program, Mr Hastie is able to set his own targets and receive a best-choice mating for each animal in the herd.

He says: If I want to focus on a particular trait, I can change that myself when running the program. This could be for hoof health, stature, milk quality or any other trait.

In fact, were already seeing big improvements in feet and legs through corrective breeding and starting to see changes in other areas.

This includes reducing udder depth and strengthening udder support we think theyll remain higher for longer and making other changes to help robotic milking.

This has involved a change of mindset and were now looking to widen rear teat placement as well as lengthen teats something we didnt do in the past.

We have also moved away from selection for production, now keeping our focus on health and functional traits. We have found that the milk is there, even without looking for it, which allows us to focus improvement on other areas.

Also aiming to improve the herds management and efficiency, the next robots to be installed will help in this endeavour.

He says: Our sixth robot will be a grazing robot, which will be used exclusively by our late lactation cows. Theyll be in strawed yards in winter and graze in summer, only receiving concentrates while at grass, when theyre having no total mixed ration.

Im confident well maintain their yields and should manage body condition score better. I think it will save 1-2 per head each day in feed costs for the last 30-40 days of lactation.

Asked how the Viking-bred cattle have impacted profitability, he believes its too early to say with any precision.

In a few years, when nearly all the herd is Danish, Ill be able to tell you but all I can say now is that we are very pleased.

FARM facts

360 milking Jerseys rising to 430 in year-round calving system

Production at 8100 litres at 5.75%BF and 4.01%P (780kg fat plus ptn)

All breeding switched to VikingGenetics for longevity and milk quality

Four A4/A5 Lely robots, increasing to six, including one grazing robot

Sexed semen produces 200 Jersey heifers/year for replacements and sale

Genomic testing introduced for all Jersey heifer calves this year

TMR fed to all milking groups except late lactation, plus concentrates to yield

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Viking genetics and robots working together at Alderston Mains - The Scottish Farmer

When it comes to healthy eating, one size does not fit all. Japanese cooking, with its emphasis on rice, fish, and vegetables, may not be the best diet for everyone, but it is marvelously suited to the physiology of the Japanese, writes physician and writer Okuda Masako.

The popularity of Japanese cuisine has soared in recent decades, and one reason is undoubtedly its healthful image. The average lifespan of the Japanese people climbed rapidly after World War II. By around 1980, Japan had the highest life expectancy of any country in the world, and it still ranks near the top. (The worlds oldest living person is also a Japanese woman.) Amid a slew of investigations into the secrets of Japanese longevity, attention quickly centered on the benefits of washoku, traditional Japanese cooking.

My research and experience have taught me that the optimal diet depends on a variety of hereditary and environmental factors. But there is no denying that washoku has contributed to the health and longevity of the Japanese people. Let us begin by examining how.

In terms of health and long life, the biggest physiological factor the Japanese have going for them is a low risk of atherosclerosis. Atherosclerosis occurs when fats and other substances build up along the walls of arteries, restricting or even blocking blood flow. In the brain, such a blockage is known as a cerebral infarction (stroke); in the heart, it is called a myocardial infarction (heart attack). The incidence of myocardial infarction in Japan is among the lowest in the world.

Scientists believe that both genetics and diet play a role in protecting Japanese arteries. One factor is a high level of good cholesterol, or HDL (high-density lipoproteins), in the blood. In a 2008 study, Japanese HDL levels were found to be roughly 10% higher than those of white Americans on average. Another reason is that fish is a big part of the traditional Japanese diet, and fish contains EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), two polyunsaturated fatty acids that help prevent hardening of the arteries. Since ancient times, the Japanese have been eating oily fish like mackerel, sardines, yellowtail tuna, and eel, which are abundant off the coast of Japan and are rich in EPA and DHA. In a 2015 study, the average concentration of DHA in Japanese maternal milk was determined to be up to six times that found in Western countries and about twice that found in China.

A second major contributor to Japanese health is the gut microbiota, the many and varied microorganisms living in the intestinal tract. A 2016 analysis of the intestinal microbiota of subjects from 12 countries found that the Japanese had the highest counts of beneficial bifidobacteria. (Interestingly, the gut microbiome of the Chinese subjects was closer to that of the Western subjects studied.) This can probably be attributed to the high fiber content of the traditional Japanese diet, with its emphasis on grains and vegetables. Dietary fiber provides a good nutritional environment for beneficial microbes and helps cleanse the gut of the harmful substances that unhealthy bacteria produce. Since it takes a generation or more to permanently alter the gut microbiota, todays Japanese probably owe their intestinal health to the dietary habits of their parents and grandparents.

All of this might lead one to the conclusion that eating washoku will automatically make one healthier. Unfortunately, it is not quite so simple. In general, the traditional diets that developed in various parts of the world were optimally adapted to the local environment and the needs of the native population. The physiology of the native population, in return, adapted to the diet.

There are obvious physical differences between Japanese people and Westerners. But the differences go beyond hair texture and eye color. There are also disparities in musculature, body fat, and body temperature, as well as various factors that affect digestion and metabolism of alcohol: hormone and enzyme secretion, the shape of the stomach, the composition of the gut flora, and so forth. Race is not just skin-deep.

The Japanese stomach is adapted to consumption of grain.

Figure 1 illustrates the stomach shapes typically found in Japanese people on the one hand and people of Westerners extraction on the other. The differences are the result of disparities in the traditional diet.

The Japanese have long relied on rice and other grains as their dietary staple. Grains are a good source of energy, but whole grains in particular take time to digest because of their high fiber content. The Japanese stomach is vertically elongated so as to store, mix, and break down such food before it continues on into the intestines. The intestines, in turn, are rich in the kinds of bacteria that help digest and extract nutrition from starchy foods.

By contrast, the traditional European diet, with its emphasis on meat and dairy products, is considerably higher in protein and fat. Since protein and fat are digested primarily in the intestines, the food needs to move more rapidly from the stomach to the gut. The digestive system evolved to deal with these demands. For example, a large quantity of stomach acid is produced so that the stomach can process the food quickly; comparatively thicker stomach muscles then push it smoothly into the intestines.Plenty of enzymes and other fluids are secreted to aid the digestion of fat and protein inside the intestines.

It has long been known that the ability of adults to digest milk varies by ethnicity and region. The bodys capacity to digest the lactose in milk hinges on continued production of the enzyme lactase. The map in figure 2 shows the global distribution of lactose-intolerant adults in various parts of the world, with higher concentrations indicated by darker shades. While most people in the British Isles and Scandinavia digest milk easily, close to 90% of adults in Southeast Asia and East Asia (including Japan) have trouble with it.

Darker shades indicate regions with higher rates of adult lactose intolerance.

Such differences in physiology can translate into serious health problems when people adopt different diets and lifestyles. One example involves vitamin D, which is essential to bone health, among other things. Vitamin D is produced inside the body when the skin is exposed to the suns ultraviolet rays, but it can also be obtained from dietary sources like oily fish. It has been suggested that Africans, who evolved in a part of the world where year-round UV exposure is high, may be less well equipped to absorb vitamin D from dietary sources, and this may be why African Americans tend to have relatively low vitamin-D levels. Some experts have warned that African Americans need to adjust their diets to avoid health problems resulting from vitamin D insufficiency. The optimum diet for any person depends on genetic makeup, as well as lifestyle and environment.

Genetics also influences the way our bodies accumulate fat. One characteristic of the Japanese constitution is the tendency to accumulate visceral adipose tissue, or fat inside the abdominal cavity, as opposed to the subcutaneous fat that collects under the skin. Unfortunately, visceral fat is the more worrisome kind.

Cross-sections showing the distribution of abdominal fat in representative Japanese (left) and Westerners (right) subjects.

This is a fairly recent phenomenon, mind you. In earlier times, obesity was relatively rare in Japan, and the incidence of chronic diseases associated with visceral fatincluding type 2 diabetes, along with other diseases like breast cancer and colon cancerwas correspondingly low. That began to change in the 1960s to 1980s, as the Japanese diet became increasingly westernized, leading to higher fat consumption and lower intake of fiber. And with more people doing deskwork and leading sedentary lifestyles, lack of exercise contributed to the rise of obesity and the accumulation of visceral fat. The result has been a significant increase in disease, raising concerns for the future.

Extensive studies have revealed that a traditional Japanese dietlow in meat and dairy products, high in soybeans and fish, and high in fiber from grains, vegetables, and seaweedis tied to very low accumulation of visceral fat. In other words, washoku is ideally suited to the physiological traits of the Japanese people, protecting them from their innate tendency to accumulate visceral fat. Without knowing the science, our forebears managed to develop, preserve, and pass down a dietary culture perfectly adapted to our own metabolism.

Washoku has other health benefits as well. Soybeans, green and yellow vegetables, and small fish eaten whole all help to build strong bones. Lifelong consumption of soy foods also contributes to the relativelylow incidence in Japan of diabetes, breast cancer, and colon cancer, all ailments linked closely to visceral fat levels, as compared with the West

One notable weakness of the Japanese diet as it has developed in the past two or three centuries is the overwhelming preference for polished rice. For the health-conscious, I would recommend brown rice, which has seven times the dietary fiber of white rice and contains substances that help the body burn visceral fat.

In recent years, science has made considerable progress in identifying genetic differences among ethnic groups. In 2016, a Japanese team of researchers released the first Japanese reference genome panel (JRG v1), a whole-genome assembly representing the genes of a typical healthy Japanese. Comparison with the human reference genome has revealed millions of single-nucleotide differences, many of which doubtless reflect significant differences in nutrition physiology. We need to abandon the one-size-fits-all approach to nutrition and consider what diet works best for each ethnic group.

Nowadays, the Japanese people are able to enjoy delicious cooking from every part of the world. That is a splendid thing, as long as we keep in mind that washoku is the bedrock of our much-admired health and longevity.

(Originally written in Japanese. Banner photo: Dairy and meat products figure heavily in the Western diet, while the traditional Japanese diet has much to offer in the area of human health. Pixta.)

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Nutrition and the Wisdom of Ethnic Cuisine: A Japanese Doctor's Perspective - Nippon.com

Would knowing the date of your death influence your actions? It did for Tiberius Caesar. Convinced by the court astrologer Thrasyllus that he had many years of life ahead of him, the paranoid old emperor chose to postpone the murder of his heir Caligula.

But by believing Thrasylluss prediction and letting his guard down, Tiberius inadvertently gave Caligula enough time to poison him first. The rest, as they say, is history which Thrasyllus had altered by deliberately overestimating his employers life expectancy.

While many of us are unlikely to find ourselves in Caesars position, knowing how many years we have left may influence many aspects of our life including when to retire, whether to take a long-awaited vacation, and even whether to opt for certain medical treatments.

My Longevity, a newly developed app from researchers at the University of East Anglia, now allows each of us to be our own life expectancy astrologer. But how much trust should we place in these predictions?

Simply put, life expectancy is how long, on average, members of any given population can expect to life. This is different from lifespan, which is the maximum length of time any member of the species can survive.

Although lifespan has changed very little if at all global life expectancy has soared by more than 40 years since the beginning of the 20th century. This was achieved through a combination of scientific discoveries and public health measures that drove down infant mortality. In the UK, life expectancy at birth is now over 80 years.

Life expectancy depends a lot on where you grow up or live. So the more a disparate population can be broken down into sub-populations who have traits in common but which are still large enough to be statistically significant the more accurate predictions become. Doing this might involve subdividing the population by sex (on average females live longer than males) or smoking status (for obvious reasons) or both.

The team of researchers used a sophisticated version of this approach when developing their app, informed by its previous research. This allows its app to factor in the life expectancy effects of controlled and uncontrolled high blood pressure, the presence of related illnesses such as cardiovascular disease or rheumatoid arthritis, ongoing treatment with statins, and serious risk factors, such as high cholesterol.

Developing the app has involved dealing with some problems along the way in estimating potential health benefits for the overall population based on those seen in clinical trials. This is because discrepancies exist between trial subjects and populations for a number of reasons but usually they are cases of what is known as tight segmentation working against you.

For example, a clinical trial of the effects of orange juice in sailors with scurvy will show profound benefits because they are a tight segment with vitamin C deficiency. But anyone expecting to see the same beneficial effects on health from prescribing orange juice to everyone taking a boat trip today is going to be deeply disappointed.

How seriously you should treat the predictions from an app of this type is basically a function of how accurately it reflects the sub-population into which you best fit. I compared my life expectancy prediction from My Longevity with calculators provided by the UK Office for National Statistics and those of two insurance companies. The predictions varied from 84-90 years. As Im 54, this may not have been a completely fair test of My Longevity because the data the team has used makes the app most accurate for the over 60s.

The major reason life expectancy calculators spit out such different figures is because there are a wide range of factors influencing the results. Being married increases your life expectancy compared to being single, as does being happy. In addition to smoking, levels of fruit and vegetable intake influence life expectancy. Perhaps unsurprisingly, levels of alcohol consumption and exercise make a profound difference to life expectancy. These are concrete lifestyle changes people can make which can add years to their lives.

The East Anglia research team hopes that access to its calculator will encourage users to adopt healthier lifestyles. Although there is some evidence that framing behaviours in terms of their effects on life expectancy is an effective way of encouraging people to embrace healthier lifestyles, superficial discussions of health and longevity often assume that everyone will seek to maximise life expectancy if only they are fed enough of the facts about it.

However, human motivation is emotional and intuitive at its core and is shaped by what a person most values in life. Propositions that accord with a persons values are typically supported. Those that dont are either ignored or rejected.

Another common mistake made by those promoting behaviour change is to assume their own dominant values are shared by the people they want to adopt the behaviour in question. This approach will only convince people who already think and feel like them. But the more developers of such apps recognise that users will only adopt certain behaviours according to their values and beliefs, the more useful these apps will be.

More here:
Longevity app calculates your life expectancy but will it make us healthier? - The Conversation UK

Editors note: This is Part 2 of a four-part series on longevity in the High Country. The series is being produced in partnership with The Aspen Times, Vail Daily, Glenwood Post Independent, Summit Daily News and Steamboat Pilot & Today. Read more at steamboatpilot.com/longevity.

DENVER It isnt noticeable at first, starting with changes to the brain that the brain can compensate for, meaning no real impact on day-to-day functions or cognition.

But as time passes, the brain can no longer compensate for these changes and the damage its experiencing. Subtle problems with memory and thinking begin to pop up. Subtle turns to noticeable. Noticeable turns to inhibiting the ability to carry out everyday activities and eventually to requiring around-the-clock care.

This is the broad view progression from pre-clinical to severe Alzheimers disease, a degenerative brain disease that becomes worse with time and age and is the most common cause of dementia, as explained by the Alzheimers Association.

In Colorado, an estimated 76,000 people are living with Alzheimers dementia, and that number is expected to increase 21% to 92,000 by 2025, a 2020 Alzheimers Association report states. As of July 2019, 14.6% of Coloradans or roughly 840,000 people were 65 or older, U.S. Census data shows.

But while generally speaking its been shown that living in higher altitude communities in places like Steamboat Springs can lead to a more active, healthier lifestyle and even prolonged life, how does living at altitude impact and correlate with degenerative brain diseases that cause dementia, like Alzheimers?

In short, the answer is complicated and not well researched by scientists and clinicians, as explained by Dr. Huntington Potter, director of the Alzheimers and Cognition Center at the University of Colorado Anschutz Medical Campus.

As far as I know, there isnt a lot of evidence one way or another about high altitudes versus low altitudes for Alzheimers disease risk, Potter said. We cant say one way or another whether high altitude is a risk factor for Alzheimers.

Alzheimers disease is namely the result of the accumulation of the protein fragment beta-amyloid outside of neurons in the brain and of an abnormal form of the protein tau inside neurons, as described by the Alzheimers Association.

At the Alzheimers and Cognition Center, which is part of both the CU Anschutz Medical Campus and School of Medicine, clinicians and researchers are dedicated to discovering effective early diagnostics, preventions, treatments and ultimately cures for Alzheimers disease and related neurodegenerative disorders, according to its website.

For Potter, that means looking at biomarkers or diagnostic proteins in the blood that can help clinicians predict the disease earlier and conducting projects that look at the longitudinal sort of lifespan of people with Alzheimers disease and other research that can quickly be translated to better care, treatment and hopefully a cure.

Right now, the center is studying a drug called Leukine, which preliminary data shows may actually improve Alzheimers disease in the short term, Potter explained. The center also is studying other drugs that attack the disease, which so far are looking very promising as well.

Leukine may be the first one we found that looks promising, but we have several coming up that look promising as well, Potter said. Its been a tremendous privilege to work with all of the clinicians and scientists and scientist clinicians at the Alzheimers and Cognition Center, and were absolutely determined to make Colorado one of the places that discovers the cure for Alzheimers disease.

When it comes to looking at the potential correlation between living at high altitude and the risk for Alzheimers and other dementia-inducing diseases, Potter and Dr. Peter Pressman of the Alzheimers and Cognition Center said it would take great effort, time and funding to research.

Pressman, who is a behavioral neurologist and researcher with the center, said on top of securing and carefully selecting a large group of people living at altitude to participate in a study, researchers would also have to follow that group for around a decade to get meaningful results, which is not impossible but not easy.

Its easy to fund a study for a few years. People give you money to do something for two to three years, but two to three years is not enough time for a process as slow as Alzheimers and dementia to really even pick up, Pressman said. Im not saying thats not possible, its doable, but it would take some effort.

Looking at this potential correlation between living at high altitude and risk of Alzheimers dementia and others is not just a difficult feat for Colorado researchers little research with concrete findings exists nationally and globally as well.

One study published in 2015 by Dr. Stephen Thielke in JAMA Psychiatry looked at deaths attributed to Alzheimers dementia reported in 58 counties in California to try to determine whether rates of dementia were associated with average altitude of residence. The study found that the counties at higher elevation generally had lower rates of dementia mortality.

Oxidative abnormalities have been long proposed to be central to the pathogenesis of dementia, the study research letter states. One group of researchers previously found that hypoxia prevents neurodegeneration in rats in experimental Alzheimer disease and hypothesized that adaptation to induced hypoxia may prevent dementia. To our knowledge, our work is the first to find epidemiological evidence for such effects. Additional work is needed to determine whether this relationship holds in other populations.

But beyond this study, there isnt much conclusive evidence for or against a correlation, as emphasized by Dr. Brent Kious, a psychiatrist, assistant professor and researcher with both University of Utah Health and the schools Department of Psychiatry.

Kious has studied the link between living at high altitude and major depressive disorder, anxiety and suicide and said he and his research team have been interested in the impact of altitude on the incidence and median age of onset of Parkinsons disease, but has not studied this impact or the effects of altitude on dementia risk.

However, Kious said decrements in cognitive performance due to chronic exposure to moderately high elevation might not necessarily translate into an increased risk of dementia, since the symptoms of dementia depend both on baseline cognitive performance and on pathological neurodegenerative processes.

It is not clear whether altitude would affect those neurodegenerative processes or not, though there is some reason to think that they involve oxidative damage so relative hypoxia might slow them, Kious said via email. However, he went on to note that relative and prolonged hypoxia has also been associated with dementia risk, too. In any case, a good epidemiological study of the association between altitude and dementia should control for things that might be associated with both.

While there may not be good data for or against high altitude as an Alzheimers and dementia risk factor, there is evidence that people living in more rural communities do not have the same access to dementia care and treatment as those living in urban areas.

According to the 2020 Snapshot of Rural Health in Colorado, produced by the Colorado Rural Health Center, 721,500 people are living in rural Colorado and 19% of the rural population is age 65 or older. Rural is defined as a non-metropolitan county is no cities over 50,000 residents, the snapshot report says.

While there are some dementia care resources in more rural Colorado communities, the Alzheimers and Cognition Center is working to do more to develop meaningful relationships with health care providers and dementia patients in the states mountain communities as part of its mission.

According to Pressman, who is heading this charge on behalf of the CU center, a lot of projects are in the planning stages and process of acquiring funding but include virtually educating medical providers, nurse practitioners and primary care doctors on Alzheimers and general healthy brain aging and mutual, participatory research with rural Colorado communities and communities of color.

Pressman explained that a lot of research related to Alzheimers overwhelmingly is based on middle class, well-educated, white participants. And so while researchers think they know a lot about the disease in general, they really only know about the disease related to this demographic group.

Through the centers outreach and efforts to better connect with underrepresented communities, Pressman hopes to conduct better science and better serve the larger Colorado community.

What motivates me is trying to do good work, trying to do good science and to makes sure our results actually represent real life, Pressman said. We want to make sure were helping everybody, not just a niche group, and that our services are available equitably to as many people as possible.

Although theres no clear correlation between living in higher altitude, mountain communities and dementia and Alzheimers risk, it is clear that as Americas aging population reaches 65 and older, these medical conditions will remain a relevant risk for seniors.

Maddie Vincent is a reporter at The Aspen Times. She can be reached at mvincent@aspentimes.com.

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The Longevity Project Part 2: An unclear correlation Colorado clinicians and researchers talk Alzheimer's risk, care in mountain communities -...

Which risk factors pose the greatest threat to a retirees finances?

The Center for Retirement Research at Boston College (CRR) recently published a paper taking a deep dive in search of answers.

The researchers looked at five factors and offered objective answers, as well as subjective answers from retiree interviews.

They considered five risk factors: longevity risk (outliving your money); market risk (investment losses); health risk; family risk (unforeseen need of a family member); and policy risk (such as cuts to Social Security benefits).

Survey participants viewed market risk as the greatest threat, due to the participants exaggeration of market volatility, according to the survey authors.

The CRR study suggests retirees should reassess the risks.

Objectively, the study found longevity risk, followed by health risk, to be the most serious factors.

So, could it be that the scariness of stock market crashes clouds our judgment?

Could it be we worry too much about market risk because its here and now, while living very long or developing health problems is something that may happen later, if at all?

If your account statement shows a large drop, you know exactly how big a hit youve taken. It poses an immediate and measurable risk to your finances.

If your doctor tells you your cholesterol is too high or that you need to lose weight well, you may feel fine, so how bad can it be? Doctors are programmed to warn about that stuff, anyways.

Sometimes, I hear people men in particular pooh-pooh the chance of their living a long life. They may say something to the effect of my dad died before 80; I likely wont last much longer. As if heredity were the only, or even dominant, factor.

Read more from the original source:
Jorgen Vik: What are the five greatest threats to your retirement finances? - The Daily Progress

National life expectancy data is not a suitable tool for retirement planning, an expert has warned.

Joseph Lu, director of longevity science at Legal & General Retail Retirement Income, made the warning at this week's FTAdviser webinar The Long and Short of Longevity Risk.

He said: National life expectancy data is not suitable for planning as it implies there is a one in twochance of outliving the figure.

"It doesnt account for health, wealth and other important factors.

If we would like a 90 per cent chanceof achieving life-long financial security, for age 65, plan for living to 100. This means planning for 35 years."

But he added: "It is not just the length of life that matters. I would also want to think about health which in turn determines needs in retirement.

Mr Lu highlighted recent research by the Pensions and Lifetime Savings Association, which showed that a couple would need almost 29,100 each year to achieve a moderate retirement, but 47,500 for a comfortable retirement.

His sentiments were echoed by Bruce Guthrie, professor of general practice at the University of Edinburgh, who said although statistics can help, they are not a guarantee.

He said: Prediction tools can help focus a clinicians mind and focus a patients mind, but these tools should not be certainty.

During the webinar, advisers heard how statistical models can be built into the client's planning process but that these should be part of an overall conversation with the individual, as there are many behavioural and personal biases around longevity and mortality that will need to be factored into pension planning.

Jon Scannell,distribution director for Legal & General Retail Retirement Income, noted that it is useful to pay attention to a variety of factors. He told listeners there were 'four Ls' that could prove a good starting-point for conversations around making the pension pot last.

These are: "Legacy, Liquidity, Lifestyle and Longevity". The challenge is for advisers to be able to balance client expectations for retirement with the facts around lifestyle, health, mortality and the various other risks that can have an effect on a pension pot.

The webinar, which was sponsored by L&G and is available online for a month, also discussed the impact of talking to clients about life expectancy, and how advisers can de-risk their business.

aamina.zafar@ft.com

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Longevity risk: The key questions answered - FT Adviser

Dr. Hinohara was still treating patients and clocking 18-hour workdays up to a few months before he passed away. He clearly loved what he did, and he was fortunate to have a sense of purpose saving lives.

Possibly my favorite piece of wisdom he shared was the concept that when you have a long life expectancy, you can spend the first 60 years working for you and your family, then the next 40 years working for the greater good and contributing to make the world a better place giving you a sense of greater purpose.

Remember the Gallup Work Engagement Study?

Lets be realistic about the world we live in today. Only 1 in 5 people truly love their work like Dr. Hinohara did. Most big companies call you family, but in the end, they serve their shareholders. Surplussing is one of the new and more despicable terms for sugarcoating when a company needs to lay people off theres a surplus of humans here, so lets reduce the surplus. Not to mention, from ages 55 to 65, you may not have the choice to keep working at your primary job.

The result? One in 5 people in the U.S. downright hate their jobs, another 3 in 5 could take it or leave it. So, 4 out of 5 workers dont share Dr. Hinoharas love of work and a sentiment to never retire.

Keep in mind I wrote You Can Retire Sooner Than You Think, so Im a little biased toward Americans being able to stop working at their current job long before age 105. However, one of the main components thats paramount to an early and happy retirement is having multiple activities/projects/endeavors that youre passionate about working on. I call these, core pursuits. Its something that Dr. Hinohara clearly had down pat.

Put core pursuits at the center of your retirement planning.

First of all, losing the dignity of work isnt easy for most people. Remember the study from Harrys that said the No. 1 predictor of a mans happiness is his job satisfaction and his feeling of impact at his company and career? Americans, both men and women, love to work and love to earn if their productivity is channeled in the right direction.

It isnt easy to replicate the energy, challenge and accomplishment you get from work its almost like rigorous exercise. The workout or run may hurt, but it makes you stronger, and healthier. In some respects, continuing to work, particularly at something you enjoy doing, offers similar benefits.

Just look at Jimmy Buffett. He made a living of singing about wastin' away again in Margaritaville, but when you look at the empire that hes built with his music, beverages, real estate, restaurants and other merchandise, its easy to see that this guy works his tail off to sell the idea of a relaxing life to others. And based on his success and his reported half-a-billion dollar net worth, its clear that hes not just in it for the money these days.

The end result of working similar to a long run or workout at the gym is very difficult to replace. So, the HROBs Happiest Retirees on the Block of the world re-create their work stimulation by deploying a long series of core pursuits.

Maybe yoga, gardening, fishing, hiking, biking, running, walking, golfing, going to church, crafting or art ends up not being enough. Thats OK. Maybe you can transition your skills into a very involved volunteer role or lower-paying nonprofit job. Maybe its starting your own small business. Consider a teaching, coaching or mentoring role. Write a book. Start a website. Join a band. Become a tour guide or historian in your town. Put your cooking skills to use to feed your community. Your core pursuits can lead you to a more fulfilling future while adding life to your years.

Get going and get growing.

I get what Dr. Hinohara was saying, but beyond following a sparse diet and taking the stairs, his advice to work forever just wont work for most Americans. We have to work and save so we can have the economic freedom to follow our passions. Its something thats typically unrealistic if you have a new mortgage and are trying to raise a family. Happy retirees find themselves in the opposite position. They can take on a job or career thats focused on feeding their soul rather than financing their family.

Remember Dr. Hinoharas reflection that once youve raised your family, the next phase of your life (60-plus) can be focused on you and the greater good around you.

Curiosity killed the cat, but a lack of curiosity is what kills the happy retiree.

Wes Moss has been the host of Money Matters on News 95.5 and AM 750 WSB in Atlanta for more than 10 years now, and he does a live show from 9-11 a.m. Sundays. He is the chief investment strategist for Atlanta-based Capital Investment Advisors. For more information, go to wesmoss.com.

DISCLOSURE

This information is provided to you as a resource for informational purposes only and is not to be viewed as investment advice or recommendations. This information is being presented without consideration of the investment objectives, risk tolerance, or financial circumstances of any specific investor and might not be suitable for all investors. This information is not intended to, and should not, form a primary basis for any investment decision that you may make. Always consult your own legal, tax, or investment adviser before making any investment/tax/estate/financial planning considerations or decisions.

Original post:
Wes Moss: You dont have to work forever, but you can use your talents - Atlanta Journal Constitution

For instance, the bacteria on your mask may make its way to your hands, and it could then spread from here.

That said, its advisable to wash your hands before you take off your mask. Its also best that you dont touch the front of the mask as you take it off. Rather, take it off by unlooping or untying the strands from your ears, making sure to avoid touching the front.

Mistake #5: Youre Wearing the Wrong Size

Theres no point in wearing a face mask if it doesnt fit well. If its too small, then youre probably leaving your nose exposed and if its too loose, then viral particles are more likely to get in through the side openings. Whats more, if your mask doesnt fit well then youre going to be constantly readjusting it, which then increases the risk of contamination.

Your mask should fit snugly on your face, but not so tight to the point where it makes it difficult to breathe normally.

Additionally, facial hair may make it harder to wear a mask so you may want to think about trimming your beard.

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12 Face Mask Mistakes You Need To Stop Making - Longevity LIVE - Longevity LIVE