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What are you doing to increase your Brainspan? – Longevity LIVE

August 26th, 2020 3:49 pm

These days its easy to feel frazzled and distracted. You may be multi-tasking and not getting enough sleep. Maybe youre anxious. And youre probably not doing enough to help your brain work efficiently. If you want to remain sharp and clear-headed as you age, taking care of your brain should be top of mind, says functional medicine expert Bryce Wylde, author of the newly released book Brainspanners.

Accumulation of toxins is associated with cognitive decline, which makes detoxifying essential.

While the brain is designed to detoxify itself, over time this process may become less efficient. Your brain may also be overwhelmed by the sheer amount of toxins its exposed to from the environment and your diet. Thankfully, there are ways you can support your brains detoxification process, says Wylde. And doing so may increase your Brainspan.

Your lifespan is the number of years youll spend on this planet. Healthspan is the number of years you will live in good health. Brainspan, explains Wylde, is the number of years you will live in good health with the healthiest brain possible.

You probably know how much you weigh, and possibly your cholesterol levels and blood pressure. But Wylde says, most people dont know what their brain is doing. We dont give our brain the attention it deserves. Yet it controls the heart, gut and every organ in the body. We arent taught a lot about how to make it healthier.

Wylde says that some of the more efficient ways to support your brains detox process include: M

While many people only think of folate as a necessary nutrient during pregnancy, it is very active in the brain and central nervous system. It also aids in cellular detoxification. Vitamin B9 is found in many fortified foods, as well as fresh fruits and vegetables including nuts and leafy green vegetables.

Glutathione is the most important detoxification molecule, essential for getting rid of harmful chemicals and metabolic byproducts that are dangerous to the human brain. The body makes glutathione but depending on our genetics, some of us are more efficient than others at making it.

Also, our ability to manufacture glutathione declines with age. Others cant get into the cells. Research has shown that a new compound called Glyteine, now available over the counter as Continual-G, raises the cellular levels of glutathione rapidly, within an hour or two.

Our brains do most of their detoxifying when were in deep, non-REM sleep. Thats when the spaces between the brains cells enlarge, and accumulated waste can be flushed away. This cant happen during waking hours. It would be like a railway crew trying to repair tracks while the trains are running.

Wylde explains that toxins lurk everywhere. These include bleach in the laundry room and chemicals in foods and cosmetics. Youve got to pee, poop, sweat, or breathe out these toxins. When your output is less than your input, your brains health may be compromised.

We spoke to Bryce Wylde about how doing something for your brain, every day, is the best thing you can do to ensure its longevity.

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The Longevity Bonus: The Upside of Aging – MediaVillage

August 26th, 2020 3:49 pm

Publish dateAugust 25, 2020

The following is an excerpt What Retirees Want: A Holistic View of Life's Third Age, a book representing the culmination of a long collaboration between authors Ken Dychtwald and Robert Morison, who have conducted award-winning research, based on national and international surveys, into the evolution of retirement in the 21st century. Ken will join the September 22 Jack Myers Leadership Conversation Why Boomers are Booming as Media's Next Big Ad Spending Surge, along with Keith Reinhard, Peter Hubbell and Susan Feldman. Register here. In this book, Ken and Robert provide readers with unparalleled insights into the minds and hearts of the retired (and nearly retired) population. In past decades, marketers and entrepreneurs have focused on younger generations, mostly ignoring retirees. Retirement was often viewed as a time of gradual decline and financial contraction. But thanks to increased lifespans and better health care, today's retireesparticularly Baby Boomersare experiencing a distinct and rewarding phase of life, ready to explore new activities, new meanings, and new opportunities. Given that this demographic also controls the largest concentration of personal wealth, businesses are missing out if they continue to ignore this large and growing market.

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The long and short of longevity: A woman’s perspective – IOL

August 26th, 2020 3:49 pm

By Opinion Aug 25, 2020

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Longevity is an accelerating macro trend. World Economic Forum (WEF) research shows that we now live a decade longer than our parents generation and two decades longer than our grandparents.

Internal statistics from retirement income specialist Just indicates a total life expectancy for a 65-year old to be 87 years for women as opposed to 82 years for men, with 25% of women at age 65 likely to reach 94 and a further 10% living to celebrate their hundredth birthday. Earlier this year, the WEF also co-launched an initiative that aims to mobilise thinking and action to strengthen financial wellness for the 100-Year Life.

Just Product Actuary Twan Wessels says that women underestimate their longevity, with research highlighting a disparity of 5-7 years between actual versus expected life expectancy. Whats more, despite the probability of living longer and outliving their male counterparts, fewer females tend to do adequate financial planning to ensure a comfortable and sustainable retirement.

According to Lynda Smith, CEO of online community platform 50Plus-Skills, many married women still seem to leave much of the retirement planning process to their husbands and do not have their own or a collective view of planning for the future. Women on their own in this season of life are often fearful about not having enough savings, she says. Frequently this is due to a divorce or to single parenthood, which puts women under significant pressure to meet monthly financial commitments and causes anxiety about running out of savings down the line.

Alarm bells should ring, adds Wessels, because in addition to needing more money for living longer, in pre-retirement women often have less time and income to accumulate sufficient savings. This may be due to temporary absence from the workplace for maternity leave or to care for children or elderly parents, and may also be as the result of sacrificed earning potential because certain jobs or roles with demanding time and travelling requirements are difficult to sustain alongside family responsibilities. Fortunately, the recent work-from-home requirements encourage remote working possibilities. This can allow for more flexibility and may help women in particular achieve more of a work-life balance.

Ensuring financial security in retirement tops the list of concerns for most people, gender aside, insists Jennifer Nedzamba, a financial planner at Netto Invest. However, Nedzamba agrees that the unique circumstances women face and societys view on traditional gender roles within families and family financial planning, adds to the anxiety some women feel when it comes to their finances.

Considering some women tend to leave the management of their familys finances to their male partners, and often outlive said partner, it is crucial that women get involved and a plan is in place to ensure sufficient retirement income that keeps up with inflation to maintain their standard of living, even after the passing of a partner, she cautions.

Wessels, Smith and Nedzamba agree that many women have not yet grasped the concept of longevity fully, and as a result have not planned adequately for retirement. In light of their shared experiences and expertise, and to help create awareness, they offer their top considerations for women approaching retirement.

Live and work for longer

Women must reimagine their future with an open mind to remain connected, teachable, relevant and involved in work, as long as health allows, says Smith. This does not mean remaining in full time employment, rather enabling a life in retirement consisting of pockets of work that keep you going financially and contribute to your pension pot.

Take control of your own financial planning

The time for women to take a more active role in financial planning is long overdue. It is important to educate yourself on money matters, be aware of all retirement options available and understand the impact or consequences of any decisions taken, says Nedzamba. If you dont have a financial plan already, uncertain times like these might just be the catalyst needed to get something in place.

Wessels recommends partnering with a trusted professional who focuses on a holistic approach to financial planning. An independent financial adviser should take time to understand your unique circumstances and needs in order to recommend an appropriate annuity strategy. Most importantly your retirement strategy must provide a sustainable income that covers your basic needs for life. The balance of your retirement savings can be invested to allow for discretionary spending and to leave a legacy. It is possible nowadays to blend life and living annuities to achieve this desired outcome.

PERSONAL FINANCE

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What This Cardiologist Wants You To Know About Vitamin D & Longevity – mindbodygreen.com

August 26th, 2020 3:49 pm

While there's a genetic component to telomere length and durability, there seem to be a few things we can do to help support our own telomeres. Steven Gundry, M.D., heart surgeon and bestselling author of The Longevity Paradox: How To Die Young at a Ripe Old Age, shared an easy one when he appeared on the mindbodygreen podcast: Make sure you're getting enough vitamin D.

"Human beings with the highest vitamin D levels have the longest telomeres, and people with the lowest vitamin D levels have the [shortest] telomeres," Gundry told mbg co-CEO Jason Wachob, referring to research in the Archives of Medical Science and the Journal of Nutrition on the association between telomere length and vitamin D levels.

It seems that vitamin D, a hormone that's essential for a number of processes in the body, works by increasing the activity of telomerase, the building blocks of telomeres that protect cellular DNA from aging. Gundry goes so far as to say that he thinks it's "the greatest hormone that exists."

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Dr. Aubrey de Grey, the father of the Longevity Movement, joins the advisory board of AgelessRx – Press Release – Digital Journal

August 26th, 2020 3:49 pm

AgelessRx, the first online platform for anti-aging treatments, welcomes Dr. Aubrey de Grey as a new member of its advisory board. Dr. de Grey, who is a biomedical gerontologist by profession, is the father of longevity movement, inseminated the fortuity of slowing down aging in a TED talk in 2005. There is probably no other single individual who has contributed more to the advancement of the progress to slow down aging.

Ann Arbor, Michigan - AgelessRx, the first online platform for anti-aging treatments, welcomesDr. Aubrey de Grey as a new member of itsadvisory board.Dr. de Grey, who is a biomedical gerontologist by profession, is the father of the longevity movement, inseminated the fortuity of slowing down aging in a TED talk in 2005. There is probably no other single individual who has contributed more to the advancement of the progress to slow down aging. His addition to the advisory board of AgelessRx is being regarded as the apex conjunction of mastery, super-ability, accomplishment, and originality, as he brings an unparalleled wealth of knowledge about the longevity space. Dr. de Grey also has a depth of relationships in the longevity space that is unparalleled.

AgelessRx CEO, Anar Isman: Many years ago my view of life was changed after watching Aubreys Ted Talk. I am among many people whose eyes were opened by Aubrey to the fact that aging is not inevitable and curing aging is a fight worth fighting. He is a visionary whose contributions have made an enormous impact on an industry that one day soon will be helping millions of people live longer healthier lives. It is an honor to have Aubrey de Grey join our advisory board.

Dr. Aubrey de Greys inaugural Ted Talk in 2005 is largely credited as launching the current longevity movement. He continues to stay in the mainstream media spotlight with a recent interview on Joe Rogans very popular podcast. In addition, Dr. de Greys research on aging in the age of Covid 19 continues solidifying him as one of the leaders of the anti aging movement.

About Dr. Aubrey de Grey

Dr. de Grey is the biomedical gerontologist who devised the SENS platform, and established SENS Research Foundation to implement it. He works on the development of medical innovations that can postpone all forms of age-related ill-health.

The main focus of Dr. de Grey is on rejuvenation: that is, the active repair of the various types of molecular and cellular damage which eventually cause age-related disease and disability, as opposed to the mere retardation of the accumulation of such damage.

He performs this work in his capacity as chief science officer of SENS Research Foundation, a California-based 501(c)(3) charity that undertakes and funds such research; as VP of New Technology Discovery of AgeX Therapeutics, a biotechnology startup developing new therapies in the field of biomedical gerontology; and also as editor-in-chief of Rejuvenation Research, the highest-impact peer-reviewed academic journal focused on postponing aging.

He received his BA in Computer Science and Ph.D. in Biology from the University of Cambridge in 1985 and 2000, respectively. Dr. de Grey is a Fellow of both the Gerontological Society of America and the American Aging Association and sits on the editorial and scientific advisory boards of numerous journals and organizations.

NOTES TO THE EDITOR:

About AgelessRx

AgelessRx is a telehealth subscription service focused on longevity therapies. Founded in October 2019, the companys mission is to help people live longer by accelerating the progress and adoption of therapies that prevent age-related diseases and work to reverse age-related damage. Designed with an education-first philosophy, consumers can find countless educational resources on available therapies, complete a free medical intake form for review by medical personnel, and, upon approval, receive routine and direct shipments within a fraction of the time it takes to visit a traditional clinic.

To learn more, visit http://www.agelessrx.com.

Media ContactCompany Name: AgelessRxContact Person: John BehrmanEmail: Send EmailPhone: 650-503-9990City: Ann ArborState: MICountry: United StatesWebsite: https://www.agelessrx.com/

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Exactly How To Dial Up Your Exercise IntensityBecause a New Study Says Thats What Longevity-Boosting Workouts Are Made Of – Well+Good

August 26th, 2020 3:49 pm

Dialing up the intensity in your exercise routine can look like a lot of things: adding a mile to your morning run, tackingone more circuit onto your HIIT session, opting for an extra chaturanga (a yoga push-up) or two in your on-demand yoga class. No matter how you choose to up the ante on your sweat routine, a new study indicates that its well worth doing. Not just because high-intensity workouts are good for your heart health (we know that already!), but because they may just increase your longevity.

The brand-new study out of the U.K. looked at nearly 100,000 Biobank participants with a mean of 62-years-old and age56 percents of whom were female. The scientists divided the subjects into different profiles based on their workout intensities, then they followed the participants health via their smartwatches over time (a mean of 3.1 years). The results? Those with a physical activity energy expenditure (or PAEE, which dictates the workoutsintensity) that was moderate or intense tended to have reduced mortality rates in comparison to those in the other profiles. In other words, researchers found that higher-intensity workouts resulted in living a longer, more healthy life.

Our results show that doing more activity of any intensity is beneficial, but that expending those calories in more intense activity is better still, Tessa Strain, PhD, study lead told the United Kingdoms Medical Research Council. By gradually building up the intensity of physical activity we do each day we can improve our future health. The results also indicate that activity volumes also have a cumulative effect, and thus even lighter activitieslike yoga, barre, or floor Pilatesthat are sustained over time could lower your risk of mortality.

If youre in the market for ways to up your intensity, you have so many options. Trainer Charlee Atkins previously told Well+Good that you can divvy up your week so that you have three days of strength training, two days of cardio, one day of yoga, and one rest dayand that blueprints just the one you need to look at when youre starting the project of adding a little more oomph to your at-home workouts. Below, youll find a video that intensifieseachtype of workout.

Dont go too far too fast, but do consider swapping in one of these workouts this week to raise your heart rate, sweat a little more, or work your muscles just abitmore than usual.

Barrys trainer Sashah Handal pulls out all stops with this workout that will send you heart racing in a 25-minute period thats shorter than most of your Zoom meetings. Just grab your mat and get ready to sweat. Look forward to plank shoulder taps, jumping lunges, and (so many) squats.

Val Verdier, headteacher of Modo Yoga in New York City has a knack for classes that feel at once restorative and vigorousand this flow is no exception. Youll test your core throughout this tough series of asanas (thats Sanskrit for poses) and roll up your mat feeling stronger and a lot sweatier.

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LeBron James’ Incredibly Detailed Sleep Habits May Be The Key to His NBA Longevity – Sportscasting

August 26th, 2020 3:49 pm

As any basketball fan can confirm, LeBron James is a pretty talented guy. Beyond his pure athletic ability, though, the LA Lakers forward is also pretty durable; 17 years into his NBA career, King James is still going strong. That continued success, though, starts with one simple thing: sleep.

For most of us, sleep isnt something we really think about; it simply happens at the end of a long day and ends far too quickly. For LeBron James, however, getting a good rest is central to everything he does on the hardwood.

RELATED: Lebron James Biggest Challenge in the NBA Orlando Bubble Isnt on the Court

These days, LeBron James is simply part of the basketball landscape; its almost impossible to imagine the NBA without him involved. Believe it or not, King James has been in the spotlight for nearly 20 years.

James, of course, burst onto the scene at St.Vincent-St. Mary High School. While he showed plenty of potential on the gridiron, his ultimate calling proved to be basketball; before long, ESPN and other outlets descended on Akron, Ohio, making the teenager a household name.

After becoming the first-overall pick of the 2003 NBA draft, LeBrons star continued to rise. While he wasnt always perfectjust ask Cavs fans about The DecisionKing James lived up to the hype. In addition to winning three NBA titles, hes established himself as a legitimate generational talent; even if you dont agree with the comparisons, it says something when a player is placed in the same bracket as Michael Jordan.

Even after 17 years in the association, the forward is still going strong. Based on his 2019-20 campaign with the LA Lakershes averaging 25.7 points and a career-high 10.6 assists per gameits safe to assume the LeBron James wont be relinquishing his crown for at least a few more seasons.

RELATED: LeBron James Has Made More Than $300 Million in the NBA, But He Still Regrets an Expensive Impulse Buy

Based on his on-court ability, endorsements, and smart investments, LeBron James has built up quite a fortune during his basketball career. While he puts plenty of that cash toward good causes, he also uses a nice chunk of change taking care of his body.

Although every personal athlete has plenty of trainers and coaches at his or her disposal, King James takes things to another level. In addition to his long-time personal trainer, Mike Mancias, the Lakers star also employs a biomechanist, recovery coach, and masseuses, among other attempts to best maintain his body; he also has his own gym with all the bells and whistles that an athlete could want.

On the whole, LeBron reportedly spends about $1.5 million per year taking care of himself. While that might sound like a sizable investment, James performance and career earnings seem to indicate that its been well worth it.

As anyone who has ever pulled an all-nighter can confirm, sleep is the key to both feeling your best and performing well. LeBron James, it seems, understands that better than most.

As documented by CNBC, James has gone on the record about his bedtime beliefs. [Sleep is] the best way for your body to physically and emotionally be able to recover and get back to 100 percent as possible, he explained on The Tim Ferriss Show. Now, will you wake up and feel 100 percent? There are some days you dont. So some days you feel better than others. But the more, and more, and more time that you get those eight [hours of sleep]if you can get nine, thats amazing.

Want to hit the sack in a way befitting King James? His long-time trainer provided some insight into what that entails.

Without giving everybody all of our secrets, No. 1 is be very, very comfortable in that room, Mancias said. Create an environment. For LeBron, its always in his hotel room, making sure the temperatures set at a particularprobably 68 to 70 degrees is probably optimal. The Lakers star also limits screen-time before bed but does make use of the Calm app to listen to some soothing sounds.

Obviously, LeBron James has a natural advantage in the talent department. Getting a good nights sleep, though, has helped him remain effective after spending almost two decades in the NBA.

I could do all the ice bags and theNormaTecsand everything that we do, that we have as far as our recovery package, while Im up, he continued. But when you get in that good sleep, you just wake up, and you feel fresh. You dont need an alarm clock. You just feel like, Okay. I can tackle this day at the highest level.

Stats courtesy ofBasketball-Reference

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The secret to Cam Smith’s longevity and why more stars play longer – NRL.COM

August 26th, 2020 3:49 pm

For much of his remarkable 19-year career, Cameron Smith has been mocked about his physique but the 423-game veteran has the strongest core of any player Kangaroos elite performance manager Troy Thomson has come across.

Nicknamed The Accountant by Melbourne Storm team-mates, Smith has been an inspiration for the growing army of players whose careers now extend well beyond 30 due to a combination of advances in diet, recovery, preparation, training methods, technology and genetics.

At 37 years of age Smith is currently the oldest player in the NRL but 60 others who have turned 30 or older have played this year and up to eight more including 35-year-old Sonny Bill Williams could join the list before the end of the season.

According to statistics provided by David Middletons League Information Services, the increase in senior players has been a growing trend since 2013, with Cronulla great Paul Gallen retiring last season as the oldest player of the NRL era at 38 years and 30 days.

While Smith is believed to be favouring retirement at the end of the season, if he was to play again in 2021 the former Australian captain would surpass Gallen as he celebrates his 38th birthday on June 18.

Manly great Steve Menzies, who retired at the age of 39 with Catalans in Super League, said: Its amazing the level that he can still play and continually do what he does.

Smith is expected to announce his future before returning from a three-match layoff due to a shoulder injury in this weekends clash with the Sea Eagles, with speculation he will retire to enable the Storm to retain Brandon Smith and Harry Grant.

It is one of the few occasions Smith has been sidelined through injury in a career which also includes 42 State of Origin appearances for Queensland and 56 Tests for Australia.

Thomson, who worked alongside Smith for his first 10 seasons at the Storm and spent a decade with him in Maroons camps and another two years with the Kangaroos, said the reason one of the games greatest players was also one of the most enduring was largely because of hard work.

As much as he probably wouldnt like to admit it he is one of the best trainers I have known, Thomson said. He is not the strongest, but his core is by far the strongest I have ever seen so his ability to just control everything through the middle part of his body is exceptional.

Genetics plays a really big part in it and I think he is blessed with some really good genes but from Smithys point of view he is probably the most well-prepared player, as well as being a really, really good footballer, who has been in and around really good programs for his entire career.

Yet it isnt only Smith who is defying age, with Brett and Josh Morris poised to re-sign with the Roosters, Canberra preparing to offer fellow 34-year-old Iosia Soliola a new deal for 2021 and 35-year-old Benji Marshall considering another season with Wests Tigers.

Raiders recruitment manager Peter Mulholland said players were often peaking later, with the average age of debutants in the NRL between 2014 and round 2 this season, when the competition was suspended, being 21.8 years of age.

There have been more players turning 30 or older this year who have played NRL this season than players 21 or younger.

Canberra have seven players who are over the age of 30 or will turn 30 later this year, including English pair Josh Hodgson and Elliott Whitehead, captain Jarrod Croker, Jordan Rapana, Dunamis Lui, Michael Oldfield and Soliola.

Croker recently re-signed, while Mulholland said the club was keen for Soliola to continue playing in his 35th year.

I dont look strategically at age, Mulholland said. Its a late-maturing sport to start with. People used to say youve turned 30, you have got to retire, but thats a load of s....

I think the changes in training, medical science and performance management has enabled people to play longer.

With Cameron Smith, I never think about his age. I just think he is a great player. Wade Graham is over 30 and the Morris boys are just getting better all the time. Its not a young mans sport as a lot of people think, it is a late maturers sport.

We are looking at talking to Sia about another year as well. It is just a year-by-year proposition. We will certainly look at Elliott Whitehead when he is up [off contract] and see how he is travelling. Jarrod Croker is no spring chicken and we have got him for another three years.

Athletes are also playing for longer at the top level in other sports around the world, with NFL legend Tom Brady still playing at 43, NBA superstar LeBron James turning 36 this year and soccer great Lionel Messi recently celebrating his 33rd birthday.

I have lost count of the number of times I have sat in a one-on-one meeting with an older player and told them the story about Linford Christie winning the Olympic gold medal at Barcelona in the 100 metres the most prestigious sporting event in the world at 32 years of age, Penrith head of performance Hayden Knowles said.

You have to be the most finely tuned athlete in the world to do that and he did it at 32. You look at James Tamou in our team, he is 32 and when he gets his shirt off he is ripped.

Athletes naturally decline with age but sports science and technology have enabled players to play for longer and the money the stars can earn has given them a greater incentive to ensure they can.

Most guys work out how valuable that attention to detail is at the back end of their careers but they are starting to work it out younger, Knowles said.

You only need to put a $ sign on each year. If you are still playing at 30 you are a pretty red-hot, experienced player who is valuable to a team, so if you can look after yourself it is potentially worth $500,000 or more.

With GPS tracking, performance staff at NRL clubs are able to monitor the workload of players in games and at training, while there are devices to measure muscle imbalances, test hamstrings and perform body composition scans in a bid to prevent or reduce the risk of injuries.

Thomson said players are also investing in recovery equipment to prolong their careers.

When I started at Melbourne in 2001 to have blokes over 30 was a very rare occurrence, he said. I think it comes down the preparation and recovery and the sports science and sports medicine teams that are in and around the clubs these days.

Some of the best players also understand that by buying a Game Ready machine or recovery boots and all those different things to aid their recovery, they are actually investing in themselves and their future. If you are getting another couple of years at the end of your career that could be worth $1 million.

Warriors recruitment manager Peter OSullivan, who helped recruit the likes of Smith, Billy Slater and Cooper Cronk to the Storm, said the emphasis on preparation and recovery, along with a reduced drinking culture, had made a huge difference to the longevity of players.

But O'Sullivan added: Theres rules for everyone and then theres Cameron Smith.

Menzies, who played 349 games for the Sea Eagles or Northern Eagles and another 128 in Super League, said experience gave senior players a significant advantage over their younger rivals if they were able to maintain fitness and motivation.

You might be two yards slower but your anticipation is better so you can take off five steps before a young bloke knows to leave because you can sense or see or feel where you need to be before they do because of experience, Menzies said.

Cam Smith has always had the ability to see things before other people see them or sense them. He is world class at everything like that.

When you are a speed-type player it is harder to play longer because that doesnt hang around for as long but his little subtleties and the way he plays is based on skill and attention and anticipation.

To kick and do all those things that he does you dont need to sprint 30 metres at speed so it is conducive to playing longer.

Thomson said the influence of Craig Bellamys disciplined regime at the Storm couldnt be underestimated in assessing why Smith, Slater and Cronk had all enjoyed long and successful careers.

However, he believes the on-field awareness the top players have also gives them an ability to avoid injuries.

The thing I notice with guys like that is they just have this innate ability on the field to see things before anyone else can and to avoid situations where they are going to get injured as well, Thomson said.

I have been lucky enough to stand in behind those guys over so many years and see them play and you look and you think hes going to get smashed here but they just have this ability to turn their body or get themselves in a position where the impact or the severity of the collision is nowhere near what it could have been.

The views in this article do not necessarily express the opinions of theNRL,ARLC, NRL clubs or state associations.

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Five Cricketers With The Longest Career-Span In ODI Cricket – Cricket Addictor

August 26th, 2020 3:49 pm

In Cricket, just like other sports, longevity is one of the parameters which is used to judge the greatness of a cricketer. And, rightly so.

One of the greatest examples of longevity is none other than Master Blaster Sachin Tendulkar. The Indian legend made his debut at an age of 16 and for the next 24 years, he battled mounting expectations, a truckload of injuries, and numerous other challenges that bowlers threw at him, but he still managed to come out with flying colors.

Longevity is an expression of a player resilience, grit, and character. It just shows you that no matter how many obstacles you may face in your journey if you have the courage and mental fortitude to battle it out, you will thrive.

Also Read- Cricketers Who Kept Their Team Ahead Of Their Family

Heres a look at five cricketers with the longest career-span in ODI cricket-

Shoaib Maliks ODI career spanned over 19 years and given the longevity, you may be tempted to think that the all-rounder would have represented Pakistan in 3-4 World Cups easily.

But Maliks career is a perfect example of the volatile nature of Pakistan cricket- One minute down, next minute up. Having made his debut against the West Indies way back in 1999, Shoaib Malik could feature in just two 50-over World Cups- the shambolic 2007 event where he was one of the lone shining lights and the 2019 edition where he was dropped midway through the tournament.

Maliks last ODI game came against arch-rivals in the 2019 World Cup, and even though it did not end in the manner he would have liked, his best days in 50-over cricket came against the Men in Blue, against whom he averaged 50.

Overall, Malik featured in 287 ODIs, scoring 7534 runs at an average of 34.56, including 44 half-centuries and 9 hundreds. Besides that, he also claimed 158 wickets at an average of 39.9.

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Daily Power Walks May Decrease The Chance Of Early Death – Anti Aging News

August 26th, 2020 3:49 pm

Simply turning a 12-minute leisurely stroll into a 7-minute power walk on a daily basis may decrease the chance of an early death by 30% according to a recent study, and adding 2 minutes of brisk walking to a 35-minute walk was found to lower the risk of early death by 21%.

Fitness tracker data and health data from 96,476 adults between the ages of 40-69 collected from the long term UK BioBank study were analyzed to show that as far as longevity goes it is not just how much you exercise it is also the intensity that matters. Findings could help fitness tracker wearables to be employed to be more specific to help improve longevity.

Our results show that higher volumes of activity energy expenditure are associated with lower mortality rates, the researchers concluded adding that achieving the same energy expenditure through higher-intensity activity is associated with even greater benefits than through lower-intensity activity.

The UK Biobank study seeks to identify genetic and environmental factors that contribute to the development of diseases and it has an accumulation of biological samples in a large repository which includes urine and blood samples. Fitness tracker data was used to calculate participant physical activity energy expenditure and how much of this came from moderate to vigorous-intensity physical activity. Participants were followed on average for 3.1 years, during this time 732 of the participants died. Higher levels of physical activity were found to be associated with a lower risk of mortality regardless of the cause of death.

The researchers concluded in their report which is published in the journal Nature Medicine that the equivalent of adding an extra 2 minutes of brisk walking to the end of a 35-minute walk on a daily basis could lower the risk of an early death by 21%.

The linkage of device-measured activity to energy expenditure creates a framework for using wearables for personalised prevention, the researchers concluded.

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Daily Power Walks May Decrease The Chance Of Early Death - Anti Aging News

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Day in the life: Drishiya Vats – Jill Lopez

August 25th, 2020 7:55 pm

As a student studying in India, Itry to experience as much medicine as Ican by getting involved in clinical rotations. I am in my last year of school, I hope to graduate in July. Our program is a five year course that includes six months of internship at different hospitals plus an internship at a zoo. Soon, I will be working with the World Veterinary Services on a project in Goa.

As the rest of the world, we are also experiencing a lockdown, so our classes now are online only and our rotations are on hold for the time being. We are hoping to go back into our school by the end of the year, but there is still uncertainty if we will.

This is what Iget up to on a typical day (pre-pandemic) as a veterinary student atKerala Veterinary and Animal Sciences University.

Breakfast the beginning of a new day

I live in a large dormitory complex called a hostel, which hosts veterinary students only. We have 100 students in my class. In my unit, most of my roommates are night owls, so Im usually one of the few awake in the early morning. Some of my friends are Muslim and they also get up around this time for their morning prayers.

My day starts at 5am, so Ihave time for breakfast and a workout. At 7:30 I go to our college mess (cafeteria) and eat typical south Indian breakfast, like idli dosha sambhar, or eggs and oatmeal. Afterwards, I come back to my room and check my emails.

Clinics in the morning

My university is located in Kerala, a state on the southwesternMalabar CoastofIndia.

Around 8:45am, I leave my hostel and ride my bike to our universitys veterinary clinic. We first work in the veterinary clinic assisting a licensed veterinarian on their duties. A typical day may be treating a sick dog, vaccinating puppies, or monitoring anesthesia during surgery. We dont just see dogs and cats, we will also have goats, cattle, birds as patients. My favorite types of cases are dermatology or ophthalmology.

Lunch

At 12:30pm we come back to the hostels mess hall for our lunch. A typical lunch for me would be rice chapati or fish and rice. I like to eat lunch with my classmates and we mostly talk about the morning cases.

Lectures and wet labs in the afternoon

After lunch, I head back to campus and we have lectures from 1-3pm on a variety of subjects like surgery, preventative medicine, and toxicology. From 3-5pm we have a practical hands on training, for example, we may learn how to perform a certain surgery or treat a certain type of case.

Dinner feeding the body and soul

Several times a week, Iplay cricket or go to the gym after Iam done with classes. Cricket is very popular here, so its always easy to find a game to join. I also spend my free time at a local stable, riding and also caring for the horses. I hope to join the army following graduation, and having an equine background will make me a better candidate.

Dinner is served at 7:30pm in the mess hall. For dinner I typically have veggies, soup, and naan, which is a round flat wheat bread. Our room and board at the hostel includes meals, but we dont get many choices, one dish is usually prepared for each meal.

After dinner, I catch up on my textbook reading or work on my assignments. When thats all done, I will grab a friend to play chess or just talk with friends. I usually go to bed around 11:30pm.

Weekends

On Friday and Saturday nights, Ilike to have a meal with friends or to watch a movie. Definitely more cricket and horseback riding.

I also like traveling, especially to places where I can enjoy nature. Kerala is one of the prominenttourist destinationsof India, with beautiful beaches. The state is wedged between theLakshadweep Seaand theWestern Ghats and has a humidtropical rainforest climate.

My family lives in Uttar Pardesh -which is in Central India and is 3500 km away from Kerala . It takes almost three days by train to travel from Kerala to Uttar Pradesh. Needless to say, I dont often visit my family during the school year.

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Hating cops is a slippery slope (opinion) – SILive.com

August 25th, 2020 7:55 pm

By tolerating attacks on police, politicians are setting a reckless example that will inevitably and seriously damage not just other communities, but the very fabric of intergroup relations upon which our city depends.

Over $1 million of damage has been done to police vehicles in vandalism shared on social media and celebrated. Cops out working - diverse men and women who are your siblings, cousins, parents, children and neighbors - are now regularly attacked and disparaged with language that in any other situation would be hate speech.

In the midst of a public health crisis with no end in sight, police and other first responders are depended on to keep a city of nearly 9 million people safe. But no first responders other than cops are being vilified. No first responders other than cops are having their jobs micromanaged by politicians who are rushing to out left one another. No first responders other than cops are being threatened with arrest for doing their job in situations that are always unpredictable, always dangerous and always involving people who do not want to be interacting with law enforcement.

Discussions about policing and accountability are happening locally, statewide and nationally. Recent events, some tragic, have put police work in a spotlight. Police unions are an important voice in those discussions, so lets really talk.

Engage in a thought exercise with me.

Education policy and politics deeply impact issues of diversity, opportunity and equity. There is inequality in our school system that damages outcomes for generations. How to address these problems in ways that keep all students and families engaged in our city is incredibly complicated. Tempers often flare among families, students, unions, activists and public officials.

On the issue of student demographics at Stuyvesant High School, the most prestigious of the specialized high schools students test into, there is an allegation that the school is too Asian, with not nearly enough students of color attending.

Would debate and legislation around that issue justify attacks on Asian-American students? Or vandalizing stores in Chinatown, Flushing, Sunset Park or Dyker Heights? Would it legitimize encampments outside Department of Education headquarters? Would it excuse vicious anti-Asian slurs spray painted on government buildings? Would violence against Chinese and Korean Americans become an acceptable form of social protest?

How to protect tenants from the economic devastation wrought by the COVID-19 pandemic is a constant worry. Whether increased unemployment benefits, hardship vouchers to cover back rent, allowing security deposits to be used for payments or pausing eviction proceedings -- policymakers and advocates have been creative in addressing this critical problem.

Gentrifying neighborhoods have luxury condo towers across the street from affordable housing. Balancing the worries of tenants and the needs of owners to cover their costs is difficult. Anger towards landlords is spiking, fueled by radical tenant activists who want to cancel rent and believe that property itself is a form of theft from the collective good. A prominent tenant organizers profile, when she was on the Steering Committee of the NYC Democratic Socialists, said she hates landlords.

Would any of the above justify violence against landlords? Would City Hall make excuses for a firebomb thrown into a property owners car? How would social media characterize vandalism against the owner of a building in Crown Heights? In the Bronx? In Sheepshead Bay? In East New York?

Race and class impact healthcare. Maternal health, cancer treatment, preventative medicine, emergency care, addiction services and mental health are just some examples of areas in which the race and economic status of the patient contribute to lesser care. Despite enormous gains addressing this disparity, challenges still exist that cost lives. Are healthcare executives targeted the way police are? Hospitals? Doctors? Nurses?

The anti-cop crowd driving too many of the conversations about law enforcement insist that the venom and violence and hate being hurled at cops is a form of expression. Change the nouns in their slogans and you get an entirely different view of things, a more honest view.

Activists -- from the ones inside City Hall to the ones who were camped outside City Hall -- are being intellectually dishonest. Their behavior and their excuses are a slippery slope which is going to hurt us all.

(Ed Mullins is president of the Sergeants Benevolent Association of the NYPD.)

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Study: Short Term Use of HIV-Prevention Medication Protects At-Risk Men on Vacation – Pharmacy Times

August 25th, 2020 7:55 pm

Study: Short Term Use of HIV-Prevention Medication Protects At-Risk Men on Vacation

The findings indicate that short-term use of pre-exposure prophylaxis (PrEP) medication could be a successful way to prevent the spread of HIV in men who have sex with men (MSM) and who have difficulty with long-term PrEP use. In addition, it may work to transition men to long-term PrEP, which has been shown to be highly effective in reducing HIV transmission, according to the study.

We started this as a feasibility study to see if we could identify barriers to short-term PrEP use and make adjustments. But we were excited when we got the results and discovered that almost all the participants were adherent to the point of protection against HIV, said study author James Egan, PhD, MPH, assistant professor ofbehavioral and community health sciences at Pitt Public Health, in a press release. This gives us a promising strategy to pursue in engaging at-risk men in HIV prevention efforts that work for them.

The research team followed 48 MSM from Pittsburgh or Boston in a pilot program to test the daily use of PrEP for 30 days, which included an out-of-town vacation, with the men starting the medication 7 days before the trip and continuing for at least 7 days after vacation. In addition, the men were given a brief session introducing them to the use of PrEP.

According to the study authors, 94% of the men had blood concentrations protective against HIV after their vacations, consistent with regular use of the medication. Moreover, nearly 75% reported condomless sex during vacation, while about one-third reported recreational drug use.

None of the men contracted HIV during their vacation, though one of the men contracted the virus during the 3-month post-vacation follow-up period when he had a lapse in use of PrEP associated with loss of health insurance and a move to a new city. Additionally, 70% of the participants indicated an interest in continuing daily PrEP use long-term.

That really stood out to us, said senior author Kenneth Mayer, MD, medical research director at The Fenway Institute at Fenway Health in Boston and professor of medicine at Harvard, in a press release. It shows us that introducing short-term use of PrEP before a vacation could lead to longer-term use. This presents an enticing opportunity to reduce HIV transmission.

The study had limitations, including only involving men who were motivated to enroll and did not address the likelihood of physicians prescribing PrEP for short-term use, the ease of obtaining PrEP for use only during vacation, or the impact of the studys brief counseling on the use of PrEP.These are all areas that our findings suggest warrant future explorations, Egan said. Our study tells us short-term adherence to PrEP during high-risk periods is tolerable in men who have sex with men, and that it could lead to long-term use. Now we need to determine how to make it possible in the real-world setting.

REFERENCEShort-term use of HIV-prevention medication protects at-risk men on vacation. UPMC. https://www.upmc.com/media/news/081220-hiv-prevention-medication-protects-men-on-vacation. Published August 12, 2020. Accessed August 20, 2020.

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Erin O’Toole wins and the overdose crisis: In The News for Aug. 24 – Lethbridge News Now

August 25th, 2020 7:55 pm

His victory over rival Peter MacKay will be a blow to some progressives, who had hoped by choosing the former longtime cabinet minister the party could finally move past some of the social conservative issues that weighed it down in the last election.

Thehours-long delay wasa less-than-auspicious beginning for the new leader, who now is racing to get a team in place before Parliament returns next month.

OToole will have to make swift choices on who will be in his inner circle, including campaign director, new party staffers, and aides on Parliament Hill.

Findinga place for Leslyn Lewis will also be key, as her climb from political newcomer to an impressive finish cements the power of social conservatives in the party.

Also this

VANCOUVER Canada needs a new approach to tackle its overdose crisis.

Thats according to the lead author of a new study that highlights a prevalence of overdoses involving non-prescribed fentanyl and stimulants in British Columbia.

There have been more than 15,000 apparentopioid-related deaths in Canada since 2016.

British Columbia has recorded more than 5,000 deaths from illicit drug overdoses since declaring a public health emergency in 2016.

The study, published today in the Canadian Medical Association Journal,looked at 1,789 overdose deaths in British Columbiabetween 2015 and 2017 in which the coroner was able to determine the substances relevant to the deaths.

Itreported thatdespite decreases in the prescription of opioids across the province, the death rate from illegal drug overdoses has continued to rise.

Dr. Alexis Crabtree, the studys lead author and resident physician in public health and preventative medicine at the Universityof British Columbia, saysit highlights what isnt working when it comes to tackling the overdose crisis.

ICYMI (in case you missed it)

OTTAWA Foreign Affairs Minister Francois-Philippe Champagne is heading to Lebanon this week to get a firsthand look at the devastation caused by this months deadly explosions in Beirut.

The trip will mark Champagnes first overseas travel since March, when countries around the world, including Canada, closed their borders to slow the spread of COVID-19.

It comes nearly three weeks after a powerful explosion at Beiruts port ripped through the city, killing at least 180 people, injuring more than 6,000 and leaving much of Lebanons capital in ruins.

Canada has so far committed $30 million to help pay for emergency food, water, shelter and medical assistance in the immediate aftermath.

During his visit, Champagne is expected to meet international aid workersand members of Lebanons embattled government, which many Lebanese believe is culpable for the explosion due to endemic government corruption and negligence.

Champagne is also scheduled to visit Switzerland, Italy and Britain during his overseas trip for meetings with UN officials and several of his European counterparts.

What we are watching in the U.S.

WASHINGTON U-S President Donald Trump says the federal government has granted emergency authorization for treating COVID-19 patients with convalescent plasma.

While Trump is calling the move a breakthrough and one of his top health officials says it is promising, other health experts say the therapeutic needs more study before it can be celebrated.

The blood plasma is taken from patients who have recovered from the coronavirus and is rich in antibodies.

It may provide benefits to those battling the disease, but the evidence has been inconclusive as to how it works or how best to administer it.

Also this

WASHINGTON One of Donald Trumps most influential and longest-serving advisers, Kellyanne Conway, says she will be leaving the White House at the end of the month.

Conway was Trumps campaign manager during the stretch run of the 2016 race, and she was the first woman to successfully steer a White House bid.

She then became a senior counsellor to the president.

Conway cites a need to spend time with her four children in a resignation letter she posted Sunday night.

What we are watching in the rest of the world

PORT-AU-PRINCE, Haiti Newly downgraded tropical storm Marco is approaching Louisiana for an expected landfall around midday today.

Tropical storm Laura, meanwhile, is forecast to move along Cubas southern coast during the day before entering the Gulf of Mexico and heading toward the same stretch of U.S. coast later in the week, most likely a hurricane.

Laura caused the deaths of at least 11 people in the Dominican Republic and Haiti, while knocking out power and causing flooding Sunday.

Marco was a hurricane most of Sunday, but the National Hurricane Center says its maximum sustained winds decreased to 110 kph after nightfall.

The centre cautions that Marco could still cause life-threatening storm surges and dangerous winds along the Gulf Coast.

This report by The Canadian Press was first published on August 24, 2020.

The Canadian Press

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Nanomedicine – an overview | ScienceDirect Topics

August 25th, 2020 7:54 pm

17.8 Commentary on Hurdles in Clinical Translation of Various Nanotechnology Products

Research regarding nanoconstructs development in the cancer treatment field has witnessed a noticeable increase after discovery of the EPR effect. However, the number of anticancer drugs that actually reached the market was considered extremely low, as out of 200,000 anticancer drugs only 15 made it by 2017 (Greish et al., 2018). The reasons why most of the nanomedicines cannot even reach the market are the hardship or inability to maintain detailed characterization of these products, unsuccessful manufacturing on large scales, and issues in their safety and efficacy. These hurdles require many developmental processes to overcome them including a precise understanding of every component and all the possible interactions between them, determination of key characteristics to understand in which possible ways they affect performance, and the extent of it. If key characteristics can be replicated under manufacturing conditions (scaling up), the efficacy of targeting at the site of action and their stability and sterility can be enhanced and/or assessed (Desai, 2012). The majority of these hurdles are summarized in Table 17.5 (Tinkle et al., 2014).

Table 17.5. Major Hurdles That Face the Commercialization of Nanomedicine

Lack of standard nano nomenclature: imprecise definition for nanomedicines

Currently used compounds/components for nanodrug synthesis often pose problems for large-scale good manufacturing (cGMP) production

Lack of precise control over nanoparticle manufacturing parameters and control assays

Lack of quality control: issues pertaining to separation of undesired nanostructures (byproducts, catalysts, starting materials) during manufacturing

Reproducibility issues: control of particle size distribution and mass

Scalability complexities: enhancing the production rate to increase yield

High fabrication costs

Lack of rational preclinical characterization strategies via multiple techniques

Biocompatibility, biodistribution and toxicity issues: lack of knowledge regarding the interaction between nanoparticles and biosurfaces/tissues

Consumer confidence: the publics general reluctance to embrace innovative medical technologies without clearer safety or regulatory guidelines

The relative scarcity of venture funds

Ethical issues and societal issues are hyped up by the media

Big Pharmas continued reluctance to seriously invest in nanomedicine

Patent review delays, patent thickets, and issuance of invalid patents by the US Patent and Trademark Office

Regulatory uncertainty and confusion due to baby steps undertaken by US Food and Drug Administration: a lack of clear regulatory/safety guidelines

One of the major concerns related to NPs is their potential incompatibility and toxicity. Studies showed that inhaling NPs can cause pulmonary inflammation as well as inducing endothelial dysfunction that might lead to further complications in the cardiovascular system. A study for evaluation of iron oxide toxicity showed that monocyte-mediated dissolution and phagocytosis of the NPs have caused severe endothelial toxicity by initiating oxidative stress. Nanomaterials used in oral DDS have been shown to accumulate in hepatic cells, which might induce the immune response and eventually cause permanent damage to the liver. The accumulation of NPs in cells has been found to cause cancer by transforming cells into the tumorous state (Jain et al., 2018; Riehemann et al., 2009). Thus, handling these nanosystems requires special equipment and caution, which increases the cost of the production process and requires further investigations of the safety of nanomaterials to have a better understanding and optimize safety during manufacturing (Hammed et al., 2016). Production of NPs in the laboratory often requires complex, multistep synthesis processes to yield the nanomaterials with the required properties. Aside from the complexity of the process, controlling conditions such as temperature and concentrations precisely is significant to achieve homogeneity of NPs in terms of desired characteristics. However, retaining temperature and concentration in large systems is harder to achieve resulting in NPs with different characteristics (Gomez et al., 2014).

NPs tend to aggregate forming clusters with several microns in size. Aggregation of NPs alters their characteristics such as reactivity, transport, toxicity, and risk in the environment. Dissolution reduces when aggregation occurs due to the decrease in available surface area that will eventually reduce the activity of NPs. For example, dechlorination rate of CT (carbon tetrachloride) by magnetite NPs has shown to decrease when aggregation of the NPs increases resulting in an inverse relationship between dechlorination rate of carbon tetrachloride and aggregation of magnetite NPs (Hotze et al., 2010; Hou and Jafvert, 2009).

All these requirements are extremely important because the majority of the nanomedicines have failed to reach the commercialization step even though their efficacy in animal models was considerably high. Due consideration must be given regarding the several difficulties such as their low targeting, low safety, low efficacy, heterogeneity of disease between individuals, inability to scale-up successfully, and unavailability in determining a convenient characterization methods (Agrahari and Agrahari, 2018; Hare et al., 2017; Kaur et al., 2014). These hurdles that face the research process of accelerated translation are summarized in Fig. 17.8 (Satalkar et al., 2016).

Figure 17.8. Major issues that face accelerated translation process of nanoparticles.

Therefore, more understanding in all aspects of nanomedicine production, characterization, and clinical processes must be fulfilled to control and improve the development processes, and increase the efficacy of the translational methods. Other significant hurdles hindering clinical translation are the insignificant incentives regarding technology transfer, as well as socioeconomic uncertainties along with the safety problems faced. In the majority of cases, consideration of commercialization aspects in early stages of development is hardly even considered thus eliminating the market-oriented development (Rsslein et al., 2017).

Nanomedicines face tough, challenging concerns when it comes to determining the applicable analytical tests in terms of chemical, physical, or biological characterization. This is mainly achieved due to their complex nature in comparison with other pharmaceutical products. Hence, there is a need for more complex and advanced levels of testing to ensure a full accurate characterization of nanomedicine products. Quantification of each component of nanomedicine is considered essential alongside the identification and evaluation of interactions between them. For more possibility in achieving successful manufacturing processes with reproducibility, these products should be investigated and understood more during the early developmental stages to identify their key characteristics. The challenges for nanomedicine during scale-up and manufacturing are considered relatively unique because other pharmaceutical manufacturing processes systems are not three-dimensional multicomponent in nature on the nanometer scale. Therefore, a certain series of obstacles in the scale-up process is required. To reach the desired safety, pharmacokinetic and pharmacodynamic parameters to produce the therapeutic effect are needed. These are further determined by the proper selections of the essential components, determination of the critical manufacturing steps, and key characteristics identification. Several methods of orthogonal analysis are essential for in-process quality controls of nanoparticle products and any deviations from key parameters could result in a significant negative impact on both the safety and efficacy of nanomedicines (Desai, 2012).

Each step in the manufacturing process of NPs must be understood extensively with the need of experienced technicians. The development process also requires more enhancements in both complexity and cost. Inadequate data regarding scaling-up processes of nanomedicine products is a major concern in the commercialization step as there are only a few reports supporting scaling-up developments. Many formulation methods have been developed for manufacturing nanomedicine products. The most common methods are nanoprecipitation and emulsion-based approaches. Generally, formulations are prepared either by precipitating the dissolved molecules (bottom-up method) or by reducing the size of larger drug particles (top-down method). Removal of the solvent in the bottom-up method is not an easy process and it cannot be controlled well either, thus explaining why this method is less often applied in industrial manufacturing (Agrahari and Agrahari, 2018; Vauthier and Bouchemal, 2009). Investments in innovative projects face several issues with the major one being the knowledge that should be obtained from the innovation. Its confidentiality is easily breached when a company uses that knowledge as it cannot prevent other companies from using it. Thus, investors are not attracted to this type of project because the total return on the investment cannot be easily appropriated (Morigi et al., 2012).

The complexities in formulating nanoproducts on large scales are due to the inability of optimization of formulation processes and achieving reproducibility. Whereas formulation steps including size reduction, homogenization, centrifugation, sonication, solvent evaporation, lyophilization, extrusion, and sterilization can be easily optimized on small-scales, its still a challenging process on large-scales. Accordingly, variations between batches cannot be controlled sufficiently thereby limiting the possibility of nanomedicine to get through commercial translation (Anselmo et al., 2017; Desai, 2012).

Another problem is that even slight changes in either the formulation or the manufacturing process can have a significant effect on the nanomedicine physiochemical properties (crystallinity, size, surface charge, release profile), which will ultimately influence the therapeutic outcome. Most of the pharmaceutical industrial facilities cannot manufacture nanomedicines because of the lack of the right equipment for the process. As nanomedicine manufacturing usually involves the use of organic solvents, the ability to correctly process and handle nanoproducts is crucial to control their safety and sterility (Anselmo et al., 2017; Desai, 2012; Kaur et al., 2014). These steps require an expensive and complicated equipment, well-trained staff, and precise control to get the required product in the right quality (Desai, 2012; Kaur et al., 2014; Ragelle et al., 2017).

To date, only 58 nanoformulations are approved based on their clinical efficacy but only a quarter of them are meant for cancer treatment. Majority of the nanoformulations could not even be reproduced successfully due to several factors including the study design, overall analysis, protocols, data collection, and the quality and purity of materials used. Besides, the poor establishment of the correlation and prediction of safety and efficacy of the nanomedicine on patients hinders the successful DDS. Targeting and drug accumulation of anticancer drugs in the site of action is considered relatively poor in mouse models. Many nanoformulations were faced with failure in different clinical trial phases. Some of them got approved but then withdrawn from the market such as peginesatide. Unfortunately, the increased failures will most probably affect the development movement in the pharmaceutical industry (Greish et al., 2018).

At the present time, regulatory agencies such as the FDA and EMEA are examining every new nanomedicine on a product-by-product basis. They are considered a unique category due to the fact that there are no true standards in their examination process (Desai, 2012). Two of the major regulatory issues that emerged at the start of nanomedicine is the lack of scientific experts in the FDA and the difficulty in classifying the product (Morigi et al., 2012). The unique characteristics of nanomedicines are directly related to their regulation hurdles, which is the same as other pharmaceutical systems such as liposomes and polymeric systems (Sainz et al., 2015).

Researchers keep investigating nanomedicines when attached to prodrugs, drugs, tracking entities, and targeting molecules. Development of robust methods and assays in quality control of nanomedicines are required for more effective monitoring and characterizations. Also, estimation of their overall performance in releasing drugs, binding to proteins, and the specificity in cellular uptake must be considered (Sainz et al., 2015; Tinkle et al., 2014).

Nanomedicine products are both complex and diverse requiring explanation of challenges to have a clear definition and an effective regulation. The lack of regulatory guidelines for these products hinders their clinical potential. Drug regulatory authorities must keep up with the rapid pace of the knowledge and technological development as they play a major role translating nanomedicines towards the market. The European Medicines Agency (EMEA) and the FDA have different requirements in evaluating new nanomedicines as well as different definitions regarding nanomedicine. Agreeing on specific regulatory procedures internationally is very important to ease the translational researches of nanomedicines. Also, better long-term monitoring of toxicity should be achieved by prolonging postmarketing surveillance especially for a patient with chronic diseases (Sainz et al., 2015; Tinkle et al., 2014).

Nanomedicines just like any other pharmaceutical formulations must offer higher value to patients to become commercially successful, and have better efficacy and safety. New nanomedicine products follow the same steps in clinical trials as other drugs. It starts with preclinical tests, then be submitted to get the IND (investigational new drug) approval and following that it enters the three stages of clinical trials, one after another to evaluate safety and efficacy of the new drug (Agrahari and Agrahari, 2018).

In recent years, toxicities caused by nanomedicines have drawn attention and been recognized to be unique to nanoparticulate systems. Hence, a minimum set of measurements for the nanoparticle like surface charge, size, and solubility are monitored so as to predict the possible toxicity of NPs. Besides, NPs can stimulate the immune system by acting as an antigen. Immunogenicity is mainly affected by the size of the nanoparticle, its surface characteristics, hydrophobicity, charge, and solubility. Hematologic safety concerns have also been observed such as hemolysis and thrombogenicity (Desai, 2012).

In vivo and in vitro studies provide the proper characterization of the interactions between the product and the biological system. The problem is that the data attained from current toxicity tests are not from clinical trials and it cannot always be extrapolated to humans. Monolayers of cell cultures are currently used to characterize immunogenicity, drug release, cellular uptake, and toxicity. However, the cellular uptake process of nanoformulations is majorly influenced by physicochemical characteristics. Thus, 3D cell systems will probably provide better outcomes (Gupta et al., 2016). More caution should be given when handling any nanosized powder due to the ability of such particles to penetrate the skin and because it can also show pulmonary toxicity (Agrahari and Hiremath, 2017; Nel et al., 2006).

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Nanotechnology In Medical Applications Market To Eyewitness Massive Growth Trends Market Research 2017 to 2022 – Scientect

August 25th, 2020 7:54 pm

Theglobal nanomedical marketwas valued at $134.4 billion in 2016. This market is projected to grow at a compound annual growth rate (CAGR) of 14.0% from 2017-2022, and should reach $293.1 billion by 2022 from $151.9 billion in 2017.

Request For Report[emailprotected]https://www.trendsmarketresearch.com/report/sample/12261

Report Scope:

This report discusses the implications of technology and commercial trends in the context of the current size and growth of the pharmaceutical market, both in global terms and analyzed by the most important national markets. The important technologies supporting nanomedicine are reviewed, and the nature and structure of the nanomedicine industry are discussed with profiles of the leading 60+ companies, including recent merger and acquisition (M&A) activity. Five-year sales forecasts are provided for the national markets including the major therapeutic categories of products involved. Specific product categories quantified include diagnostics, cancer, CNS, anti-infective agents, cardiovasculars and anti-inflammatories.

Report Includes:

An overview of the global markets for nanotechnology used in medical applications Analyses of global market trends, with data from 2016, estimates for 2017, and projections of compound annual growth rates (CAGRs) through 2022 A review of technologies involved, in-depth analysis of applications in practice, and evaluation of future or potential applications Information on many significant products in which the nano dimension has made a significant contribution to product effectiveness A look at the regulatory environment, healthcare policies, demographics, and other factors that directly affect nanotechnology used in medicine Analysis of the markets dynamics, specifically growth drivers, inhibitors, and opportunities Coverage of strategies employed by companies specializing in nanomedicine to meet the challenges of this highly competitive market

Get Complete TOC with Tables and [emailprotected]https://www.trendsmarketresearch.com/report/discount/12261

Summary

Nano-enabled medical products began appearing on the market over a decade ago, and some have become best-sellers in their therapeutic categories. The principal areas in which nanomedical products have made an impact are cancer, CNS diseases, cardiovascular disease and infection control. The Summary Table gives estimates of the historical and current markets for these nanomedicine areas with a forecast through 2022.

The U.S. market is by far the largest in the global nanomedicine market and is set to continue to dominate the world marketplace; however, other national markets are expected to increase their shares over the next five years.

Reasons for Doing the Study

Nanomedicine is already an established market. Unlike some other potential applications of nanotechnology, which are still largely experimental, nanomedicine has already produced some significant products in which the nano dimension has made a significant contribution to product effectiveness. Now that aspects of the nanomedicine market are established, it is appropriate to review the technology, see its practical applications so far, evaluate the participating companies and look to its future.

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Interview: The NDB team on its revolutionary nano-diamond batteries – New Atlas

August 25th, 2020 7:54 pm

A cheap, safe, self-charging battery that delivers high power for decades without ever needing a charge? That's a game changer. California-based company NDB is making some outrageous promises with its nano-diamond battery technology, which could completely disrupt the energy generation, distribution and provision models if deployed at scale.

Each of these batteries, which can be built to fit any existing standard or shape, uses a small amount of recycled nuclear waste, reformed into a radioactive diamond structure and coated in non-radioactive lab diamonds for safety.

We explained the technology in detail in our original NDB nano-diamond battery breakdown, but we also had the opportunity to speak with members of the NDB executive team. CEO Dr. Nima Golsharifi, COO Dr. Mohammed Irfan and Chief Strategy Officer Neel Naicker joined us on a Zoom call to talk about the technology and its potential for disruptive change.

What follows is an edited transcript.

Dr Nima Golsharifi: Our battery is based on the beta decay and alpha decay of radioisotopes. The technology we have encapsulates this radioisotope in a very safe manner, which allows it to be used in basically any application that current batteries are being used for.

Loz: The particular type of carbon that you're using, where do you get that?

Nima: Basically we're using a range of different isotopes, not just one particular one, but access to these are through different methods. We have some partners in collaboration at the moment that can provide us with them.

But they're basically taken from nuclear waste. So we can recycle them and use the raw materials for our application. But we can also synthesize it in large scale in our facility. So both are possibilities.

Loz: OK. So what part of a nuclear reactor creates this waste? What's it doing before it becomes waste?

Nima: Basically, some parts of the nuclear reactor, like the moderator and the refractor, are being exposed to radiation from the fuel rods. Over time they become radioactive themselves. That's the part that they have to store as nuclear waste.

So this part could be taken away, and through some process, either gasification or some other processes we've designed, we can convert that into a useful raw material for our batteries.

Sheikh Mohammed Irfan: Dr. Nima, maybe you can also talk about how big of a waste problem that is for the nuclear industry currently.

Nima: Sure. At the moment, their expenditure is more than a hundred million dollars every year. Nuclear waste is a very large issue across the world. And beside this, there's basically no other way to re-use it in a safe solution.

So what we're doing covers two challenges in one. Converting nuclear waste into a battery that generates power in a very safe manner. Once this battery is used and it can have a very long life span it becomes a very safe byproduct that's of no harm to the environment.

Loz: Right. So I saw a number somewhere that these batteries can last for 28,000 years.

Nima: Let me correct that. It depends on the type of radioisotope you're using, and for every application the lifetime is different. But what we can say is that the battery would operate for the lifetime of the application itself, for sure. For some applications, much higher. So if you're talking about electric vehicles, our battery could run for around 90 years without the requirement of recharging.

When it comes to something like consumer electronics, it'd be more like 9 years. In some small sensor applications, it can go for up to 28,000 years.

NDB

Loz: I understand. So what sort of quantities of this waste are there around the world? Is this super common stuff, or is it reasonably finite?

Nima: Basically we're covering two different kinds of nuclear waste. One is intermediate, and the other is high level. So there will be a time where we have recycled the entire amount of nuclear waste, and we'll need new solutions for the raw material. But as I mentioned, we'll be able to produce this raw material through other methods, including transmutation.

That's a process that's currently being used, and not something we've invented ourselves. It was invented by MIT, and it involves a centrifuge to separate out the isotopes. The main ingredient is nitrogen, which is the major component of air, so it's a very cheap solution.

Loz: So you've got your nuclear waste, it's obviously dangerous for humans. How does it become safe to be used in a battery?

Nima: Basically, we can generate a high amount of cover from the radioactive substance. We're using a combination of technologies within our structure that can make it very safe to users. Mainly it comes down to the fact that we're using diamond structures.

Diamond itself has different interesting properties. It's one of the best heat sinks available at the moment, for example. That on its own covers thermal safety. When it comes to mechanical safety, diamond is one of the strongest materials in the world. 11.5 times stronger than steel. So again, that itself makes the battery tamper-proof and safe.

In addition to that, we have a combination of other technologies, including the implantation of the radioisotopes within the diamond structure, which stops the spread of the radioisotopes even if the structure is broken down which is kind of impossible without access to specific tools like lasers and others.

So in general I can say it's a combination of technologies that we've either innovated or invented that create a very safe structure as a battery.

Irfan: I'd like to add to that, that using radioisotopes as a source for energy is not new. We have nuclear medicine, where patients are treated with controlled equipment, which has always given effective results. Similarly, we have had nuclear-powered submarines and aircraft carriers. Of course, that's a completely different process, but it's been able to successfully and safely deliver power and energy without safety issues.

What Dr. Nima has highlighted is that the choice of diamond as a material is one of the strongest natural materials, and it acts as a powerful shielding and protection mechanism.

Loz: Right. Can you describe how the energy is extracted and harnessed?

Nima: Maybe I can give an example that could help you understand. Let's go to solar cells, everyone's familiar with those. These convert the energy from light radiation into electricity in photovoltaic cells.

In our case, we're converting the radiation from alpha/beta decay alpha and beta radiation directly into electricity. And the mechanism we're using is simple crystalline diamond. As I mentioned before, we have another layer, which is fully crystalline diamond, creating extra shielding and safety for this structure.

Neel Naicker: What Nima's describing is how the radioactivity produced by the body is actually more than what you get from these batteries. They're quite safe.

Loz: So in terms of evaluating batteries for use in cars, eVTOLs and things like that, the main metrics seem to be energy density, power density, safety in a crash, that sort of thing. Do you know what sort of figures you're looking at with these batteries?

Nima: When it comes to energy density, the energy density of a basic radioisotope is far beyond anything else on the market.

When it comes to power density, the solution we have will give a higher level. But compared to the way that energy density is higher, power density is not that much higher. But it's still significantly better than other batteries in the market.

And as far as crashes, no crash could break down our structure at all. Because you're using the diamond, and the specific mechanisms that make it stronger. The only way to get through the structure we have is the use of specific tools and lasers, which are quite expensive.

Neel: Another way to look at this is to think of it in an iPhone. With the same size battery, it would charge your battery from zero to full, five times an hour. Imagine that. Imagine a world where you wouldn't have to charge your battery at all for the day. Now imagine for the week, for the month How about for decades? That's what we're able to do with this technology.

Loz: It would strike at the heart of the disposable model the phone companies tend to use.

Neel: You've hit the nail on the head there. A couple of things. One is the ability for us to power things at scale. We can start at the nanoscale and go up to power satellites, locomotives Imagine that.

Secondly, we're taking something that's a big negative radioactive waste, very dangerous and turning it into something productive that provides electricity.

The third thing is that we wanna use this technology to get low-cost electricity to places that need it. We've now disrupted the whole mechanism of the creation and storage of power. There's a lot of infrastructure needed before you can flip a light switch and a light comes on.

But with what we've created, you don't need that infrastructure. You could put one of these batteries in a home, and boom, you've eliminated the whole infrastructure. Imagine the disruption that's gonna cause, for good or for bad. It'll upset a few people.

We've taken something that's really harmful to the environment, a problem, and created energy. And for places that don't have the electrical infrastructure in place, we want to provide that at a very low cost.

NDB

Loz: Let's talk about cost a little. Obviously lithium batteries cost a lot, they're a primary component of the cost of electric vehicles. Do you guys have a sense for what these things could cost in a commercial environment?

Nima: Yes, we've done financial modelling around this. A lot of applications have been considered. What we can say is it'll depend on the application, but it should be at a good competition level with current lithium-ion batteries.

In some cases, you're a little bit higher in price for production, and in others, when it goes to scale, we're a cheaper solution. Let me give you an example. Take the battery for a Tesla car, it costs somewhere in the region of US$9-10K. Our battery will cost something in the region of US$7-8K. But it's different in different applications.

Loz: So, cheaper and it never needs charging, and it lasts for vastly longer than any lithium cell.

Irfan: Not only is it a few thousand cheaper for the battery pack, but ours recharges itself. So on a Tesla, you need to recharge, stop, over time the battery wears itself out. Ours lasts for a long time.

We'll probably have them available under some sort of subscription model, pay as you go, but it'll be substantially cheaper than what the mechanism is today for a Tesla car.

Loz: Extraordinary. How far along is this technology? How far are we off mass production? Where are you at with prototyping and testing?

Nima: We're in the prototyping stage at the moment. We've completed the proof of concept, and we're about to start the commercial prototype. However, the pandemic has happened, and the lab has been shut down for some time.

But basically once the laboratories are open, we do require around 6-9 months to complete our commercial prototype, and following that to go through the regulatory process, to bring the first few applications for the battery into the market in less than two years' time.

Loz: So it's not far off.

Neel: Just to give you an example, we'll take Google, which has data centers all across the world. Amazon, Facebook, all of these companies. In confidential conversations we've had with some of these parties, we've spoken about how they use and dispose of more Uninterruptible Power Supplies (UPS) than anyone on the planet. Google always has to be on. And those UPS units have a use by date, they have to discard them.

Our product will be able to support that, while reducing the carbon footprint, and lasting far, far longer. That's a game changer when you consider how big an operation something like AWS is. It'll be a huge product for that.

A secondary product will be for the satellite market, where there'll be no regard for whether it's radioactive or not. Low-power satellites, we'll be able to power those for a long, long time without having any regard to whether they're facing the Sun, or getting any Sun on their solar panels, or whatever.

It changes the whole dynamic. Not only have we disrupted the whole energy infrastructure for creating and delivering power, we can also make big changes to the business model for a lot of companies. Big concerns can just become negligible.

This will change a lot of industries. In the future, we could look at using these to power nanorobots moving inside the body. It works from the nanoscale up to large scale. We think it'll be very impressive.

Loz: So the limits on this technology will be what, availability of the raw materials? Regulations? Do you see any regulatory barriers?

Irfan: It's a good question. We've done a comprehensive study on the regulatory and compliance aspects of our technology. Fortunately there are other devices already on the market that use radioisotopes and radioactive material inside them. Some are in the medical industry, like pacemakers. There are already different types of regulations in place.

So the matter here would be our design complying to those regulations, and we've been doing that over time.

Neel: In your home, you'll have smoke detectors, right? All of those have the same radioactivity as well. That's one point.

When it comes to availability, there's enough raw materials out there that we can develop for a long time. That's not the issue. Also, on the regulatory side there are some markets we can go into immediately without any concerns there. Aerospace, military, many others where there aren't the same requirements for compliance.

For a car, it may be different. For a hearing aid, it may be different, or a consumer product. But there are some applications where it won't be a problem at all.

Loz: Right. This is perhaps a bit of a crass question to ask, but do you guys have to pay for this nuclear waste, or are people paying you to take it away?

Irfan: (Laughs) I'm glad you brought that up! We've got a few places that have offered to pay us to take it away. It's a nuisance for them. They have to store it, and you can imagine the regulations around that. In many cases, they have to keep the public a certain distance away. They'll actually pay us to take this stuff away.

So it's a secondary opportunity for us from a revenue standpoint, and we've discussed this with several partners.

Loz: What a wonderful business to be in, where you're paid to take your own raw materials.

Neel. I wanna drive one thing home. If you take a look at the map of energy use in the world, and the map of wealth in the world, they're very similar. One thing we're trying to do with our application is trying to get some of these devices out to places where kids don't have electricity to do their homework, or to power clean water technology.

We're very adamant that this be a component of our business. And while we can't mention too many names, we've spoken with several big partners who would support this effort. Some of these companies feel they need to do good in the world, and providing electricity to places across the world that don't have it is a great opportunity for them.

Again, they don't have the huge infrastructure in place. But we don't need the infrastructure. We don't need power stations, or power lines, or any of that, to provide power. We're adamant as a team that we will give back in a major way that today's infrastructure won't allow.

Loz: In terms of the IP around this, how much do you guys own, and how much competition do you expect?

Irfan: Right now, we have patents pending around our technology. I think we're quite ahead of the competition that exists in the market, we started much earlier than the others and our technology is more advanced.

We thank the NDB team members for their time and look forward to learning more as development progresses.

Source: NDB

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Interview: The NDB team on its revolutionary nano-diamond batteries - New Atlas

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Nanorobots Market Incredible Possibilities, Growth with Industry Study, Detailed Analysis and Forecast To 2026 – Scientect

August 25th, 2020 7:54 pm

The latest research on the Global Nanorobots Market that covers growth factor, future trends, and focuses on overall knowledge that can help to make decisions on the current market situation. Nanorobots report provides information on Size, Type, Service, Output, Revenue, Growth Rate, Gross Margin, and opportunities with potential risk analysis. The Nanorobots research study defines top company profiles with trends around the world present in the market. The report also discusses financial developments with the effect of COVID-19 on the market of Nanorobots across years. TheNanorobots research executes financial adjustments that occur on the market year after year, with details on future opportunities and risks to keep you ahead of the competitors.Nanorobots market research has driven you to expand your company.

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Bruker, Jeol, Thermo Fisher, Ginkgo Bioworks, Oxford Instruments, Ev Group, Imina Technologies, Toronto Nano Instrumentation, Klocke Nanotechnik, Kleindiek Nanotechnik, Xidex, Synthace, Park Systems, Smaract, Nanonics Imaging, Novascan Technologies, Angstrom Advanced, Hummingbird Scientific, Nt-Mdt Spectrum Instruments, Witec

To Request an Exclusive Sample Report for Nanorobots Market @ https://www.marketgrowthinsight.com/sample/132933

Scope of the Nanorobots Market Report:

The demand for Nanorobots is projected to expand, during the forecast period, from USD million in 2020 to USD million by 2025. The global market report is a systematic study that focuses on the overall demand structure, development trends, business models and business of top countries in the global market for Nanorobots. The study focuses on well-known global Nanorobots suppliers, market segments, competition and the macro market.

The Nanorobots study focuses on the prospects for growth, constraints, and market analysis. The research offers Porters five-force Nanorobots industry analysis to understand the effect of various factors such as supplier power bargaining, competitor competition, new entrant challenge, competitor risk, and buyer bargaining power on the market.

Market Segmentation:

A brief overview of the global Nanorobots market has been presented according to the most recent report. TheNanorobots evaluation notes the concept of service/product in many end-user sectors along with other implementations of these goods or services. The Global Nanorobots Market Report presented a thorough assessment of the latest industry developments, extensive regional analysis, and competitive analysis for the 2020-2025 review period.

Geographically, the detailed analysis of consumption, revenue, Nanorobots market share and growth rate, historic and forecast (2015-2025) of the following regions are covered:

North America (United States, Canada, Mexico)Europe (Germany, UK, France, Italy, Spain, Russia, Others)Asia-Pacific (China, Australia,South Korea,Japan, India, Southeast Asia, Others)Middle East and Africa (UAE, Saudi Arabia, Egypt, South Africa, Nigeria, Others)South America (Brazil, Argentina, Columbia, Chile, Others)

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In this study, the years considered to estimate the market size of Nanorobots are as follows:

KEY QUESTIONS ANSWERED:

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Nanorobots Market Incredible Possibilities, Growth with Industry Study, Detailed Analysis and Forecast To 2026 - Scientect

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Stem cells shown to delay their own death to aid healing …

August 25th, 2020 7:53 pm

Already known for their shape-shifting abilities, stem cells can now add death-defying to their list of remarkable qualities.

A new study shows how stem cells which can contribute to creating many parts of the body, not just one organ or body part are able to postpone their own death in order to respond to an injury that needs their attention. The study was done in planarians, which are tiny worms used as model organisms to study regeneration because of their ability to recover from any injury using stem cells.

Planarian stem cells, even when challenged and under a lot of duress, will still respond to an injury by delaying death, said Divya Shiroor, first author and a graduate student in Dr. Carolyn Adlers lab, in the College of Veterinary Medicine.

The study, published May 7 in Current Biology, is the first to demonstrate this reaction in planarians.

The research team exposed planarians to radiation, then subjected half of them to injury. Radiated worms that had not been injured experienced predicted levels of stem cell death. Stem cells of the injured worms, however, survived, gathering around the site of the wound and postponing their deaths to mount a response.

We show that this inevitable radiation-induced cell death can be significantly delayed if animals are injured soon after radiation exposure, said Shiroor.

This could have important implications for cancer research and therapies, particularly when examining chemotherapy and surgery options for patients.

By understanding how injury prompts planarian stem cells to withstand radiation, Shiroor said, we hope to identify genes that, if shared with mammals, could perhaps help hone existing therapies.

Planarians are commonly used in basic research because of their similarities to humans. Like humans, planarians have stem cells, similar organs and similar genes, but are much more adept at responding to injury, thanks to their higher volume of stem cells and lack of a developed immune system, which in humans complicates the healing process.

This really simplifies the process of understanding the effects of both injury and radiation on stem cells, and allows us to study it directly without being hampered by parallel processes integral to wound healing, such as inflammation, that get simultaneously triggered in mammals, Shiroor said.

By uncovering the mechanisms that govern stem cells after wounding in a system like planarians, researchers could also apply this knowledge when engineering stem cells to respond similarly in the human body.

Labs have many ways to understand how planarians use stem cells to successfully recover and regenerate, but the Adler labs combination of radiation and injury to identify a novel stem cell response is unique. The researchers plan on digging deeper to understand how the stressed stem cells know that there is an injury and what role other cells may play in their response.

We have identified a key gene that is required for stem cell persistence after radiation and injury, Shiroor said, and we plan on using this as a stepping stone for further exploration.

Melanie Greaver Cordova is managing editor at the College of Veterinary Medicine.

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Stem cells shown to delay their own death to aid healing ...

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Expression Therapeutics Announces Success in Developing a Stem Cell Lentiviral Gene Therapy for Hemophagocytic Lymphohistiocytosis (HLH) | DNA RNA and…

August 25th, 2020 7:53 pm

DetailsCategory: DNA RNA and CellsPublished on Tuesday, 25 August 2020 10:13Hits: 244

ATLANTA, GA, USA I August 24, 2020 I Primary HLH is a family of devastating primary immune deficiencies with limited treatment options and no gene therapies under clinical testing. Expression Therapeutics has developed a promising and potentially curative gene therapy candidate for familial hemophagocytic lymphohistiocytosis (HLH) type 3 (FHL3). Untreated, FHL3 presents as a hyper-inflammatory state with multi-organ damage leading to premature death. Expression Therapeutics expects to rapidly progress candidates for other common forms of primary HLH as well.

"We are excited to announce this expansion of our gene and cell therapy pipeline beyond our lead stem cell lentiviral gene therapy candidate for hemophilia A that is entering Phase 1 clinical testing. Through ongoing research and development incorporating our core technology platforms, Expression Therapeutics has been able to rapidly generate promising therapeutic candidates for our HLH portfolio and several other critical disease areas with significant unmet clinical need," said Christopher Doering, Ph.D., Chief Scientific Officer of Expression Therapeutics.

Proof of concept for stem cell lentiviral gene therapy of FHL3 was demonstrated using primary patient cells and a genetic mouse model of FHL3. A key component in this success was the integration of one of Expression Therapeutics' core technology platforms that facilitates the rapid generation of transgenes with superior potency. Our lead candidate successfully restored exocytosis and cytolytic function to primary patient cells as well as a murine disease model strongly supporting the advancement of this pipeline product candidate.

"We believe there are three key aspects to FHL3 that make it a strong candidate for hematopoietic stem and progenitor cell (HSPC) lentiviral vector (LV) gene therapy. First, preclinical and clinical studies suggest that less than 20% genetically corrected cells are required to reverse most FHL3 disease symptoms. Second, because of the autologous nature of stem cell-based lentiviral gene therapy, the grave risk of graft vs host disease is eliminated. Third, with stem cell-based lentiviral gene therapy there will be no wait time to find a sufficiently human leukocyte antigen-matched donor," said Trent Spencer, Ph.D., President of Expression Therapeutics.

According to Deanna Fournier, Executive Director of the Histiocytosis Association, "We are very excited about the possibilities this work offers. Our HLH community, and the entire histiocytosis community, is very hopeful and excited about the future!"

Expression Therapeutics is a biotechnology company based in Atlanta and Cincinnati. The current therapeutic pipeline includes advanced gene therapies for hemophilia, neuroblastoma, T-cell leukemia/lymphoma, acute myeloid leukemia (AML), and primary immunodeficiencies such as hemophagocytic lymphohistiocytosis (HLH).

SOURCE: Expression Therapeutics

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Expression Therapeutics Announces Success in Developing a Stem Cell Lentiviral Gene Therapy for Hemophagocytic Lymphohistiocytosis (HLH) | DNA RNA and...

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