StemCell Therapy

I wrote here about the reports of rather short antibody persistence in recovering coronavirus patients, and whats been coming out in the two weeks since then has only made this issue more important. In that post, I was emphasizing that although we can measure antibody levels, we dont know how well that correlates with exposure to the virus nor to later immunity from it, and that T cells are surely a big part of this picture that we dont have much insight into.

This Twitter thread by Eric Topol is exactly what I mean, and this article that he references is an important read. Its schematic at right (see also here) will help make clear that antibody levels are only one aspect of the immune response to the infection its an important one, but were making it look even more important than it is because its by far the easiest part of the process to measure. The T-cell response (much harder to get good data on) is known to be a key player in viral infections, and is also known to be highly variable, both between different types of pathogens and among individuals themselves. The latter variations are also beginning to be characterized among patients in the current pandemic. We have to get more data on it across a broader population of patients in order to make sense of what were seeing.

Many readers will have seen, for example, this new paper from The Lancet on a large study in Spain. Testing tens of thousands of people across the country continues to show that (on average) only about 5% of the population is seropositive (that is, has antibodies to the virus). There are a lot of interesting findings such as rather large differences in those positive testing rates in different regions of the country, as well as the realization that at least one-third of the people who now test positive never showed any symptoms at all. But we are still not sure if this means that 95% of the Spanish population has never been exposed to the virus, because we dont know how many people might have cleared it without raising enough of an antibody response to still be detectable. This paper does show that seroprevalence was about 90% in people 14 days after a positive PCR test, which indicates that most people do raise some sort of antibody response, but we dont know how many of these people will still show such antibodies at later testing dates. Remember the paper discussed in that link in the first paragraph above, which found that 40% of asymptomatic patients went completely seronegative during their convalescence.

In other words, the Spanish survey may appear to show that 95% of the country has not yet been exposed to the coronavirus, but thats almost certainly not true. The authors do mention that cellular immunity is important and not something that they were able to address, but the combination of that factor plus the apparent dropoff in antibody levels with time makes these large IgG surveys almost impossible to interpret. But note that if there are indeed many people who have been exposed but do not read out in such surveys, that we also have no idea how immune they are to further infection. At a minimum, youd want to know antibody levels over time, T-cell response over time, and (importantly) what a protective profile looks like for both of those. We barely have insight into any of this: the large-scale data are just a snapshot of antibody levels, and thats not enough.

We have similar data here in the US: several surveys of IgG antibodies show single-digit seroconversion. You could conclude that we have large numbers of people who have never been exposed and indeed, the recent upswing in infections in many regions argues that there are plenty of such people out there. But we need to know more. We could have people who look vulnerable but arent perhaps they show no antibodies, but still have a protective T-cell response. Or we could have people who look like they might be protected, but arent perhaps they showed an antibody response many weeks ago that has now declined, and they dont have protective levels of T-cells to back them up. Across the population, you can use the limited data we have and our limited understanding of it to argue for a uselessly broad range of outcomes. Things could be better than we thought, or worse, getting better or deteriorating in front of our eyes. We just dont know, and we have to do better at figuring it out.

See the rest here:
More on T Cells, Antibody Levels, and Our Ignorance - Science Magazine

The adage all things in moderation applies not to just to food and drink, but also to the legions of bacteria inside our guts helping us digest that food and drink. It turns out the rule may also extend to the lesser understood bacteriophages, which are viruses that infect the bacteria living inside us. Like Russian nesting dolls, our bodies host close to 100 trillion bacterial cells that make up our microbiomesand those bacterial cells have their own inhabitants.

Were appreciating more and more that the most abundant microbial entities in the human gut are actually viruses, says Eric Martens, Ph.D., associate professor of microbiology and immunology at the University of Michigans Medical School. His team has been exploring the puzzling way bacteria and their viruses appear to coexist inside the human gut. The secret may lie in a hairy-looking sugar coating bacteria used to defend not only against attacks from the human immune system, but also from various viruses seeking a way in.

Using a common gut bacteria Bacteroides thetaiotaomicron, or BT for short, Martens team began to look at the complex interaction between BT and viruses, by pitting them against each other in the lab.

When challenged with viruses, or phages, collected from waste water, some of the bacteria were able to resist infection while some were not. When a particular phage comes along that can kill certain members of the population, it does so and the resistant bacteria quickly grow out, says Martens.

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However, instead of permanently altering the receptor that allowed the viral penetration, and potentially harming itself, some of the bacteria temporarily turn on a resistant state through a reversible process called a phase variation. But some of members of the bacterial population, unaware of the phages continued presence, turn off this resistance switch, leaving them susceptible to infectionand on and on.

The team genetically engineered the BT strain to express just one of eight chemically-distinct capsules and a version with no coating at all. In all cases, infection could be blocked by some, but not all, of the capsules. Surprisingly, the researchers noted that the bald bacteria were also able to evade infection. We were intrigued to see we could take away all of the capsules and still infect it with these phages and the bacteria could still survive, which necessitates that they have a backup mechanism in place, Martens says.

See original here:
How Viruses and Bacteria Balance Each Other in the Gut Microbiome - Michigan Medicine

(This story is written in partnership with .)

Theres nothing worse than coming down with a debilitating flu or cold during the summer monthsspending three days sprawled out on the couch while your friends are at the beach is pure torture.

wants to keep you from falling ill this summer by sharing valuable information on vitamins that can fortify your immune system, strengthen memory, support nerve function, and much more. You dont have to take a handful of supplements every morning in order to get the vitamins you need. Instead, you can reap the benefits from specific vitamins by integrating certain superfoods into your diet.

This vitamin has antioxidant properties and plays an important role in your vision, immunity, cell growth and division, and reproduction. Like other antioxidants, vitamin A is capable of protecting your cells against free radicals, which can contribute to heart disease and some forms of cancer. One can get their recommended dose of vitamin A through supplements or by consuming foods like spinach, dairy products, carrots, and cantaloupe.

The recommended daily doses for all of these essential vitamins can be found on .

Vitamin B-6 is important for the maintenance of the immune and nervous systems while promoting normal brain development. This vitamin can be derived from bananas, chickpeas, potatoes, poultry, and fishnow you have an excuse to make baked potato wedges and crispy chicken strips for dinner tonight. People with kidney conditions or genetic diseases may be predisposed to a vitamin B-6 deficiency, which can lead to a weakened immune system, confusion, and depression.

The regular consumption of vitamin B-12 is imperative for everyone, and those who follow vegetarian or plant-based diets are more at risk of being deficient. Vitamin B-12 is can be derived from meat, fish, poultry, and dairy products. This vitamin is central in the production of DNA and red blood cells while also supporting cell metabolism and nerve function. People with a deficiency in vitamin B-12 may experience fatigue, anemia, mood disturbances, weakness, intestinal problems, and even nerve damage.

Vitamin C is best known for its antioxidant properties that can fend off a cold and its ability to help the body absorb and store iron. This vitamin also aids in the formation of blood vessels, cartilage, muscles, and collagen. Similar to vitamin A, vitamin C protects your cells against free radicals that may cause heart disease and some forms of cancer. Vitamin C can be found in citrus fruits, berries, tomatoes, cabbage, broccoli, spinach, potatoes, and Brussel sprouts. Many people choose to take vitamin C supplements in a delicious gummy form.

Take a look at Vitamin page to better understand safe dosages and side effects of oral vitamin C supplements.

This vitamin is vital for bone health as calcium can only be absorbed by the body when vitamin D is present. Vitamin D can also be absorbed from direct sunlight, which is why people who experience seasonal depression or those living in rainy cities are encouraged to take vitamin D supplements. Symptoms of a vitamin D deficiency can include bone density loss, mood changes, fatigue, and muscle cramps. Vitamin D isnt naturally present in many foods but companies will often fortify dairy and cereal products with it.

Vitamin E is present in foods that you probably consume on a regular basis like olive oil, almonds, peanuts, margarine, meats, dairy, dark leafy greens, and fortified cereals. This vitamin is an antioxidant and can also protect your cells from free radicals while maintaining the health of your blood, brain, skin, eyes, and reproductive system.

Figuring out what vitamins you should be consuming can be rather confusing, especially for those with pre-existing conditions. iMD Healths Vitamin FAQ page can answer some of the most common questions that people may have about vitamins.

For more information on these six vitamins, visit iMD Healths page.

Follow iMD Health on , , and for updates.

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Six vitamins that can improve your body's vital functions and immune system - Straight.com

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New Delhi: As the coronavirus pandemic continues to rage through the world, scientists are making new revelations about the virus every day.

Here are some of the latest research developments on the Covid-19 front.

Scientists in Canada have launched clinical trials focussed on strengthening the immune system for cancer patients one of the most vulnerable populations to protect them from Covid-19.

The trial involves IMM-101, an inactivated bacteria that broadly stimulates the innateimmune system, which is the first to kick in when the body encounters a novel pathogen.

The researchers hope that boosting cancer patients immune systems with IMM-101 will protect them from developing severe Covid-19 and other dangerous lung infections.

The researchers said that an effective vaccine providing specific protection against Covid-19 could take another year or more to develop. Meanwhile, they believe the IMM-101 may be able to protect cancer patients from developing a serious Covid infection.

Also read: Asthma does not increase risk or severity of Covid-19, says new study

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A review of Covid-19 patients has shown that cases of brain complications linked to the coronavirus infection, such as confusion, stroke and inflammation of the brain, are occurring across the globe.

Published in The Lancet Neurology, the study has found that strokes, delirium and other neurological complications have been reported from most countries with large outbreaks of the disease.

The infection caused by the novel coronavirus has been mostly associated with problems such as difficulty in breathing, fever and cough. However, it is now becoming clear that other problems can also occur in patients.

For this study, researchers analysed findings from Covid-19 studies across the globe that reported on neurological complications. The review included studies from China, Italy and the US. It found nearly 1,000 patients with Covid-19-associated brain, spinal cord and nerve diseases.

While these complications are uncommon, the large number of Covid-19 cases globally means the overall number of patients with neurological problems is also likely to be high.

Naturally occurring molecules called resolvins can be harnessed to control the life-threatening immune reaction, called a cytokine storm, in Covid-19 patients, scientists have said.

A cytokine storm is when the bodys immune system overreacts and begins attacking healthy cells too.

The cytokine storm in Covid-19 patients can lead to respiratory failure, organ damage and potential death.

In a study published in the Cancer and Metastasis Reviews, researchers have said that controlling the local and systemic inflammatory response in Covid-19 may be as important as anti-viral therapies.

They suggest that a family of molecules naturally produced by the human body may be harnessed to resolve inflammation in patients with severe Covid-19. This would reduce the acute respiratory distress and other life-threatening complications associated with the viral infection.

Resolvins can actively turn off inflammation. Researchers have previously demonstrated that resolvins and related molecules can play a role in preventing cancer metastasis and progression.

These are current clinical trials on these molecules, to look at their use against other inflammatory diseases. Scientists have suggested that they could be re-deployed for the management of Covid-19.

Scientists have identified the differences in lung physiology and immune function in children that could explain why they are less susceptible to severe Covid-19 illness than adults.

Published in the American Journal of Physiology-Lung Cellular and Molecular Physiology, the study suggests that children naturally have less ACE2 in the lungs than adults. Angiotensin-converting enzyme 2s, called ACE2, allow SARS-CoV-2 to enter the bodys cells.

According to the study, only about 1.7 per cent of the first 1,49,082 cases in the US were under 18 years of age.

The findings from the study require further examination, and may hold the key to identifying therapeutic agents, researchers have said.

Months of self-isolation and social distancing can trigger stressors in the body that increase vulnerability to upper respiratory viruses and perhaps coronavirus, a study has suggested.

To slow the spread of coronavirus, many communities issued stay-at-home measures, increasing interpersonal stressors like loneliness, loss of employment and familial conflict.

According to an article published in the Perspectives on Psychological Science, these stressors may be powerful predictors of how a person will respond if exposed to coronavirus.

In a series of studies, researchers found that participants experiencing interpersonal stressors had a greater chance of developing upper respiratory illnesses when exposed to cold viruses.

Interpersonal stressors might play a similar role in response to the coronavirus, increasing a persons vulnerability to Covid-19.

The study indicates that social support may offer a protective shield against respiratory infection and illness.

Also read: CanSino, Moderna, Novavax: A list of Covid vaccines under clinical trials across the world

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Trial to see if immune booster can protect cancer patients from Covid-19 - ThePrint

COVID-19

Scientists ponder human challenge trials for COVID-19 vaccinesThousands of volunteers from around the world are willing to be exposed to live COVID-19 virus to test whether vaccines might work. No such trials are planned in the U.S. yet, but researchers and bioethicists say such trials have worked before and might be tried once the risks are better understood.Media contact: Claire Hudson, crhudson@fredhutch.org

Experts share insights on coronavirus vaccines at Fred Hutch virtual eventIn a webinar, Fred Hutch President and Director Dr. Tom Lynch interviewed former Hutch president Dr. Larry Corey and Dr. John Mascola, director of the federal Vaccine Research Center, about their work at the center of efforts to speed the development of coronavirus vaccines.Media contact: Claire Hudson, crhudson@fredhutch.org

COVID-19 and cancer expose societys health care gapsFred Hutch public health scientists have been working to disrupt preventable health disparities in cancer and other diseases for decades. Now theyre using their expertise to protect vulnerable communities dealing with the very disparate spread of COVID-19.Media contact: Claire Hudson, crhudson@fredhutch.org

Antibodies a hot topic in COVID-19 researchWhen the pandemic struck, dozens of scientists at Fred Hutchinson Cancer Research Center set their existing work aside and began applying their antibody-wrangling skills. Experience with other viruses is guiding efforts to develop new tests, treatments and assays to counter SARS-CoV-2, the cause of COVID-19.Media contact: Molly McElroy, mwmcelro@fredhutch.org

What happens if the coronaviruss spikes mutate?In a first of its kinds study, scientists led by virologist Dr. Jesse Bloom did a deep mutational scan of the receptor-binding domain of SARS-CoV-2, the area that binds to the ACE2 receptor in human cells and allows the virus inside. The work could have implications for vaccine design and understanding how the virus could evolve to escape immunity.Media contact: Molly McElroy, mwmcelro@fredhutch.org

Eating the rainbow and other food tips for uncertain timesStress-eating an entire loaf of garlic cheese bread may give you comfort but it won't do much for your immune system. We turned to Fred Hutch experts for practical tips on how to eat during the current pandemic or any time of upheaval without losing any of the important nutrients needed to fight disease or prevent gaining weight.Media contact: Tom Kim, tomkim@fredhutch.org

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Infectious disease

Antibody blocks Epstein-Barr virus in preclinical trialFred Hutch researcher Dr. Andy McGuire and his team have shown that an antibody isolated from patients blocked the Epstein-Barr virus in preclinical studies, which is good news for a vaccine. EBV causes mononucleosis and is responsible for Burkitt lymphoma and a wide range of cancers and immune disorders globally.

Media contact: Molly McElroy, mwmcelro@fredhutch.org

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Clinical oncology and cancer prevention

Making clinical trial information more accessibleDr. Heather Cheng recently won a Cancer Clinical Investigator Team Leadership Award from the National Cancer Institute to focus on translating clinical trial information in new ways, to help patients identify potential opportunities to participate in trials.Media contact: Molly McElroy, mwmcelro@fredhutch.org

Immunotherapy trial in advanced bladder and other urinary tract cancers shows 'exciting' resultsResults from a large trial of the immunotherapy drug avelumab for patients with advanced urothelial cancer could change how cancers of the bladder and other parts of the urinary tract are treated.Media contact: Molly McElroy, mwmcelro@fredhutch.org

Building genetic diversity into cancer researchWith a $3.5 million award from the National Cancer Institute, Fred Hutch researchers are launching an ambitious effort to build more equity into cancer risk prediction. Their aim: creating and disseminating colorectal cancer risk-prediction models also known polygenic risk scores for the multiethnic populations that need them.Media contact: Claire Hudson, crhudson@fredhutch.org

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Cell biology

In cancer, the context 'makes' the mutationHutch scientists discover how a gene can both drive and inhibit cancer in preclinical models of small-cell lung cancer.Media contact: Molly McElroy, mwmcelro@fredhutch.org

New open source software empowers scientists to uncover immune secretsCancer is maddeningly complex, and its interplay with the immune system involves a huge cast of cells and much chemical chatter. Scientists at Fred Hutchinson Cancer Research Center want to make studying that complex network significantly easier and cheaper.Media contact: Tom Kim, tomkim@fredhutch.org

Mutated skin stem cells self-correct to prevent cancerResearchers at Fred Hutchinson Cancer Research Center shed light on why inherited cancer-driving mutations don't always lead to cancer. In new work in mice, they show that skin stem cells that share a tissue-wide mutation restrain tumor development by balancing mutation-driven skin cell overgrowth with a reduced rate of skin stem cell renewal.Media contact: Molly McElroy, mwmcelro@fredhutch.org

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Basic sciences

Discovering new strategies used in arms race between bacteria and the viruses that infect themHutch postdoctoral fellow Dr. Kevin Forsberg was approved for a NIAID New Innovators Award to study how bacteria have evolved to prevent viral infection, and viruses have evolved to overcome bacterial defenses. The work could have implications for new antimicrobials and manipulating the microbiome to improve health.Media contact: Molly McElroy, mwmcelro@fredhutch.org

Pudgy middle age: Does a little fat have an upside?Scientists from Fred Hutchinson Cancer Research Center studying cellular aging in yeast have discovered that a little extra fat could protect against stress.Media contact: Molly McElroy,mwmcelro@fredhutch.org

Studying how maternal immune factors shape infant healthImmunologist Dr. Meghan Koch has been named a 2020 Pew Scholar in Biomedical Sciences. Her research examines how maternal immune factors in breast milk influence infant microbiome, immune development and health.Media contact: Molly McElroy, mwmcelro@fredhutch.org

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Other notable news

Mourning Dr. Supriya 'Shoop' Saha, rising star in liver cancer research

An update on our efforts to change

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AtFred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutchs pioneering work inbone marrow transplantationled to the development ofimmunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nations first National Cancer Institute-funded cancer prevention research program, as well as the clinical coordinating center of the Womens Health Initiative and the international headquarters of theHIV Vaccine Trials Network.

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Tip Sheet: SARS-CoV-2 antibodies, COVID-19 and health disparities, eating in tough times and immune protection in breast milk - Fred Hutch News...

Plasma transfers exercise benefit in mice

Exercise has a broad range of beneficial healthful effects. Horowitz et al. tested whether the beneficial effects of exercise on neurogenesis in the brain and improved cognition in aged mice could be transferred in plasma (blood without its cellular components) from one mouse to another (see the Perspective by Ansere and Freeman). Indeed, aged mice that received plasma from young or old mice that had exercised showed beneficial effects in their brains without hitting the treadmill. The authors identified glycosylphosphatidylinositol-specific phospholipase D1 as a factor in plasma that might, in part, mediate this favorable effect.

Science, this issue p. 167; see also p. 144

Reversing brain aging may be possible through systemic interventions such as exercise. We found that administration of circulating blood factors in plasma from exercised aged mice transferred the effects of exercise on adult neurogenesis and cognition to sedentary aged mice. Plasma concentrations of glycosylphosphatidylinositol (GPI)specific phospholipase D1 (Gpld1), a GPI-degrading enzyme derived from liver, were found to increase after exercise and to correlate with improved cognitive function in aged mice, and concentrations of Gpld1 in blood were increased in active, healthy elderly humans. Increasing systemic concentrations of Gpld1 in aged mice ameliorated age-related regenerative and cognitive impairments by altering signaling cascades downstream of GPI-anchored substrate cleavage. We thus identify a liver-to-brain axis by which blood factors can transfer the benefits of exercise in old age.

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Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain - Science Magazine

Written by Jayashree Narayanan | Pune | Updated: July 9, 2020 6:38:55 pm Lifestyle coach Luke Coutinho on dry fasting and why it matters for your body. (Source: PR Handout)

Dry fasting for good health has raised eyebrows for its complete abstinence from food and water for an extended period, but the trend has been presented as a superior form of fasting and cleansing by Luke Coutinho in his book The Dry Fasting Miracle: From Deprive to Thrive, published by Penguin Random House India.

Coutinho, a holistic lifestyle coach-integrative medicine, who has co-authored the book with Sheikh Abdul Aziz Nuaimi aka Green Sheikh, from UAEs Ajman royal family, advocates dry fasting and intermittent fasting for healthy living. He talks to indianexpress.com on the book, why fasting is for everyone, and how it could be a way to build immunity given the pandemic concerns.

Excerpts:

Why do you think fasting is important?

Fasting in earlier times was built into ones lifestyle; people ate early because there was hardly any light after sunset and their next meal would only be after sunrise. This practice spread to all religions as a discipline due to its health and spiritual benefits. Sickness too was followed by fasting, because it allowed the body to redirect its energy towards healing and repairing. So, fasting is very natural to us, however, we have moved too far away from this concept because of the habit of constant nibbling, an abundance of food and storage options, etc. Our bodies were never designed to eat the amount of food we actually eat today. Overeating turns out to be one of the most common causes of sickness, more so when the quality of food is bad and inappropriate.

Today, science is proving how necessary fasting is for the immune system, digestive system, energy, spirituality, cardiovascular health, obesity, mental health and so much more.

Fasting draws up an image of no food, no water, and basically starving. How is dry fasting different?

Fasting is not starvation. Fasting is not deprivation. Fasting is a discipline where one willingly gives their body and digestive system a break, redirecting the energy towards rejuvenation and detoxification. Fasting is way more disciplined and planned. Skipping meals is not fasting.

Fasting must be practiced around the same time, so our body builds a memory around when it can expect food. Starvation can lead to nutritional deficiencies and acidity, whereas a well-planned fasting schedule eradicates acidity.

Isnt it dangerous for the body to go without food and, more importantly, water for more than 12 hours?

Dry fasting is a cleansing practice that involves complete abstinence from food and water (in any form) for a brief period of time, which could range from 10 hours to 16, 18, 20 hours, depending upon an individuals comfort level.

Our digestive system utilises almost 80 per cent of the energy into digestion, absorption and assimilation with 20 per cent of the energy towards healing, repair, recovery, growth, rejuvenation, detoxification and building the immune system. Too much eating, eating at the wrong timings, overeating can all drain energy, leaving little or no energy for repair and recovery. Fasting gives the digestive system a temporary shutdown, boosting the immune system, stem cell regeneration, hormonal balance, etc.

Dry fasting also sends our body into the autophagy mode (prolonged fasting) wherein its intelligence sacrifices the sickest cells and activates stem cell regeneration. All of this and more can be achieved through fasting, provided its done the right way.

Of course, if someone has a medical condition and cannot fast, they must refrain or modify it according to what their health experts recommend. For example, dry fasting may not suit someone with recurrent UTI infection, so he/she may adopt intermittent fasting. Or someone on water restriction may not be able to do intermittent fasting and can take short fasts under expert guidance only.

Interestingly, the book also mentions hard dry fasting, which means absolutely no contact with water, not just consumption of it but also bathing, washing or cleaning. Is it possible?

Yes, for a brief period of time. Also, hard dry fasting is intense, so its a personal choice whether one is comfortable with fasting by not washing hands, bathing, brushing, or handling water. Not many people are because they go to offices and travel or work and that is absolutely fine. Soft dry fasting (which includes brushing, bathing, etc) if done the right way is powerful in itself.

Fasting is viewed from a religious angle. But in the book, you mention, it is more than that. Can you elaborate?

Fasting does have religious and spiritual significance but its benefits extend beyond that. In fact, it improves the health of an individual from all dimensions physical, mental, emotional, intellectual as well as spiritual.

Fasting is also turning into another fad simply because it is used as a quick fix to achieve health goals, especially losing weight and belly fat.

Fasting is not a solution for weight gain. Use it to instill discipline with reference to eating and constant nibbling, start listening to your body.

Secondly, individuals try to complete with each other on fasting and the number of hours fasted. If someone is doing a 16-hour fast, everyone wants to do a 16 hour fast. Fasting is not a competition. Its what suits you. There is no magic number of hours one should fast.

Lastly, some people claim to be fasting but still have tea/coffee/juices, etc. Such an approach can be detrimental to ones health. Fasting is not a fad.

You mention that the human body is designed for fasting and the simplest way to begin is to have an early dinner. But, people rarely follow that and tend to even eat at odd hours. Is it healthy?

Times may have changed, but not the way the human body functions.While the wisdom of early dinner comes through our grandparents, today, science is proving how late-night meals mess up our digestion, immunity, blood sugar levels, weight, etc. The very fact that the pancreatic cells have melatonin receptors on them proves that our pancreas is meant to shut down when our body starts to secrete melatonin which is when the sun sets. A person who has had a late-night dinner would be able to answer how heavy and uncomfortable it could make one feel the next day and even during the course of the night. Even worse, if the dinner is heavy, because our body is just not designed to digest it at night.

By far, eating an early dinner which is as close to sunset is a powerful lifestyle change. It can result in better immunity, digestion, energy levels, better skin and hair, etc.

Considering each and everyones body systems are different, do you think dry fasting is everyone?

Absolutely. What do you lose by trying? Most people do not fear fasting, they resist moving out of their comfort zones. There are so many people who report literally magical benefits from fasting. If someone is in a dilemma, read about these inspiring stories.At the same time, fasting doesnt have to suit all. Also, if one form of fasting doesnt suit a person, for e.g. dry fasting, in case of a health condition like recurrent UTI, they can adopt intermittent fasting. In the end, its about what suits a person.

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Fasting is not starvation or a fad, it is a discipline: Luke Coutinho - The Indian Express

LIVINGSTON, NJ Federal officials have released a list of businesses across the nation, including in Livingston, which were approved for loans under the Paycheck Protection Program (PPP).

More than 4.9 million loans worth roughly $521 billion have been approved for businesses and nonprofit organizations across the United States under the program, which was established by the Coronavirus Aid, Relief, and Economic Security Act (CARES Act).

See a list of awardees in Livingston below.

The aid is meant to help small businesses keep workers on their payrolls during the COVID-19 crisis. Funds can also be used to pay interest on mortgages, rent, and utilities. PPP loans have an interest rate of one percent and can be fully forgiven under certain conditions. (Learn more about the program)

Roughly 22,000 entities in New Jersey were approved for loans greater than $150,000. Awards in the Garden State also included loans to higher education institutions, private schools, manufacturers, car washes, real estate agent companies and nonprofits.

Earlier this week, the U.S. Small Business Administration (SBA) and U.S. Treasury released a list of loan recipients by town, adding a big caveat about the data:

Several companies that made the list have since questioned its accuracy, claiming that they didn't apply for or receive the funds the government says they did, CNBC reported.

See a list of approved loans over $150,000 in Livingston via the searchable database below. Enter the town's name where it says "Search business name of town" to begin.

More here:
Coronavirus PPP Loans In Livingston: Where The Money Went - Livingston, NJ Patch

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In-Depth Qualitative Analyses Include Identification and Investigation Of The Following Aspects:Healthcare Nanotechnology (Nanomedicine) Market Structure, Growth Drivers, Restraints and Challenges, Emerging Product Trends & Market Opportunities, Porters Fiver Forces.

Summary of Healthcare Nanotechnology (Nanomedicine) Market:It is defined as the study of controlling, manipulating and creating systems based on their atomic or molecular specifications. As stated by the US National Science and Technology Council, the essence of nanotechnology is the ability to manipulate matters at atomic, molecular and supra-molecular levels for creation of newer structures and devices. Generally, this science deals with structures sized between 1 to 100 nanometer (nm) in at least one dimension and involves in modulation and fabrication of nanomaterials and nanodevices.

Nanotechnology is becoming a crucial driving force behind innovation in medicine and healthcare, with a range of advances including nanoscale therapeutics, biosensors, implantable devices, drug delivery systems, and imaging technologies.

The classification of Healthcare Nanotechnology includes Nanomedicine, Nano Medical Devices, Nano Diagnosis and Other product. And the sales proportion of Nanomedicine in 2017 is about 86.5%, and the proportion is in increasing trend from 2013 to 2017.

On the basis on the end users/applications,this report focuses on the status and outlook for major applications/end users, sales volume, market share and growth rate of Healthcare Nanotechnology (Nanomedicine) market foreach application, including-

Anticancer CNS Product Anti-infective Other

On the basis of product,this report displays the sales volume, revenue (Million USD), product price, market share and growth rate ofeach type, primarily split into-

Nanomedicine Nano Medical Devices Nano Diagnosis Other

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Important Healthcare Nanotechnology (Nanomedicine) Market Data Available In This Report:

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Potential Impact of COVID-19 on Research report explores the Healthcare Nanotechnology (Nanomedicine) Market for the forecast period, 2020-2026 -...

This article was originally published here

Liang C, et al. Sci China Life Sci 2020 Review.

ABSTRACT

Many years of fundamental studies on viral genome packaging motors have led to fruitful applications. The double-stranded DNA (dsDNA) viruses package their genomes into preformed protein shells via nanomotors including several elegant and meticulous coaxial modules. The motor is geared by the hexameric RNA ring. An open washer displayed as hexametric string of phi29 motor ATPase has been reported. The open washer linked into a filament as a queue with left-handed chirality along the dsDNA chain. It was found that a free 5- and 3-dsDNA end is not required for one gp16 dimer and four monomers to assemble into the hexametric washer on dsDNA. The above studies have inspired several applications in nanotechnology and nanomedicine. These applications include: (i) studies on the precision motor channels have led to their application in the single pore sensing; (ii) investigations into the hand-in-hand integration of the hexametric pRNA ring have resulted in the emergence of the new field of RNA nanotechnology; and (iii) the studies on the motor stoichiometry of homologous multi-subunits that subsequently have inspired the discovery of new methods in highly potent drug development. This review focuses on the structure and function of the viral DNA packaging motors and describes how fundamental studies inspired various applications. Given these advantages, more nanotechnological and biomedical applications using bacteriophage motor components are expected.

PMID:32617827 | DOI:10.1007/s11427-020-1752-1

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Translation of the long-term fundamental studies on viral DNA packaging motors into nanotechnology and nanomedicine - DocWire News

Global Nanotechnology in Medical Market 2020 by Company, Regions, Type and Application, Forecast to 2025 offers knowledgeable information on the market strategy, market orientation, and expert opinion. The report provides the tactical analysis of the market share, growth factors, demand, industry size, regional segmentation, dynamics as well as prices variant for its forecast year from 2020 to 2025. The report delivers a brief overview of the global Nanotechnology in Medical market focusing on product specifications, manufacturing processes, cost structures, market segmentation, and end-user applications. The research study covers industry trends and recent developments in the market. It showcases potential, most recent patterns, and the difficulties and challenges that the market is facing.

Competitive Structure:

Competitive and company share analysis has been given in the report. The study focuses on the presence of several major and leading vendors in the Nanotechnology in Medical market. The key players are included in the report with analysis with coverage of price, revenue, cost, company profile, contact credentials, and among others. The report also gives future demand, the quantity of production, required raw material, and the health of the organization. Important strategies such as acquisitions, mergers, and R&D collaborations are highlighted to help major players expand their distribution channels and develop products competitive pricing.

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NOTE: This report takes into account the current and future impacts of COVID-19 on this industry and offers you an in-dept analysis of Nanotechnology in Medical market.

Some are the key players taken under coverage for this study are: Amgen , Roche , Merck , Novartis , Smith and Nephew , Pfizer

The regional category includes major regions such as North America (United States, Canada and Mexico), Europe (Germany, France, United Kingdom, Russia and Italy), Asia-Pacific (China, Japan, Korea, India, Southeast Asia and Australia), South America (Brazil, Argentina), Middle East& Africa (Saudi Arabia, UAE, Egypt and South Africa).

Market segment by product types considering production, revenue (value), price trends: Nano Medicine, Nano Diagnosis, Other

Market segment by applications considering consumption growth rate and market share: Hospitals, Clinics, Others

Moreover, the report set up beneficial Nanotechnology in Medical counter approaches to deliver competitive benefits. The report addresses the needs of the customers in terms of data availability, analytics, statistical analysis, and accurate forecast of the industry. The report investigates potential and niche segments/regions exhibiting promising growth and information for market players to sustain and enhance their footprint in the industry. The researchers behind this research study have exposed some of the significant trends of marketing channel development, indirect marketing, and direct marketing.

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Crucial Aspects of Nanotechnology in Medical Market Report:

Various analytical tools are employed to present SWOT analysis, a feasibility check, investment return study, and growth trend of Nanotechnology in Medical players. An outlook market perspective states various growth driving and restraining factors. Based on historic and present data the market growth is presented in this report. Various company segments like applications, regions, manufacturers, and product types are covered. The competitive scenario analyzed in this report will help other players in studying the development scope and opportunities with market potential.

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Global Nanotechnology in Medical Market 2020 Research on Import-Export Details, Business Standards and Forecast to 2025 - 3rd Watch News

Japanese researchers Jin Liu, Tatsuaki Tagami, and Tetsuya Ozeki have completed a recent study in nanomedicine, releasing their findings in Fabrication of 3D Printed Fish-Gelatin-Based Polymer Hydrogel Patches for Local Delivery of PEGylated Liposomal Doxorubicin. Experimenting with a new drug delivery system, the authors report on new potential for patient-specific cancer treatment.

The study of materials science continues to expand in a wide range of applications; however, bioprinting is one of the most exciting techniques as tissue engineering is expected to lead to the fabrication of human organs in the next decade or so. Such research has also proven that bioprinting may yield much more powerful drug delivery whether in using hybrid systems, multi-drug delivery systems, or improved scaffolds.

Here, the materials chosen for drug delivery are more unique as the researchers combined printer ink with semi-synthesized fish gelatin methacryloyl (F-GelMA)a cold fish gelatin derivative.

In providing aggressive cancer treatment to patients, the use of doxorubicin (DOX) is common as an anti-carcinogen for the treatment of the following diseases:

DOX may also cause serious cardiotoxicity, however, despite its use as a broad-spectrum drug. As a solution, PEGylated liposomal DOX, Doxilhas been in use for treatment of cancer with much lower cardiotoxity. The nanomedicine has also been approved by the FDA, and is used for targeting local tumors; for instance, this type of drug delivery system could be suitable for treating a brain tumor.

PEGylating liposomes can prolong their circulation time in blood, resulting in their passive accumulation in cancer tissue, called the enhanced permeability and retention effect, state the authors.

Using a 3D bioprinter, the authors developed liposomal patches to be directly implanted into cancerous cells.

(a) Synthesis of fish gelatin methacryloyl (F-GelMA). (b) Hybrid gel of cross-linked F-GelMA and carboxymethyl cellulose sodium (CMC) containing PEGylated liposome. The reaction scheme was prepared in previous studies

We used a hydrogel containing semi-synthetic fish-gelatin polymer (fish gelatin methacryloyl, F-GelMA) to entrap DOX-loaded PEGylated liposomes. Fish gelatin is inexpensive and faces few personal or religious restrictions, stated the authors.

Fish gelatin has not been used widely in bioprinting, however, due to low viscosity and rapid polymerization. To solve that problem, the authors created a bioink composite with elevated viscosity.

Viscous properties of drug formulations used as printer inks. (a) The appearance of F-GelMA hydrogels containing different concentrations of CMC. (b) The viscosity profiles of F-GelMA hydrogels containing different concentrations of CMC. The data represent the mean SD (n = 3).

And while hydrogels are generally attractive for use due to their ability to swell, for this study, the researchers fabricated a variety of different materialswith the combination of 10% F-GelMA and 7% carboxymethyl cellulose sodium (a thickening agent) showing the highest swelling ratio.

Swelling properties of hydrogels after photopolymerization. (a) Swelling ratio of different concentrations of F-GelMA. (b) Swelling ratio of mixed hydrogel (10% F-GelMA with different concentrations of CMC). The data represent the mean SD (n = 3).

Design of the different 3D geometries: (a) cylinder, (b) torus, and (c) gridlines.

Patches were printed in three different sample shapes, using a CELLINK bioprinter syringe as the authors tested drug release potential in vivo. Realizing that surface area, crosslinks density, temperature, and shaker speed would play a role, the team relied on a larger surface volume for more rapid release of drugs.

Printing conditions of patches.

While experimenting with the torus, gridline, and cylindrical sample patches, the researchers observed gridline-style patches as offering the greatest potential for sustained release.

Drug release profiles of liposomal doxorubicin (DOX). (a) Influence of shape on drug release. The UV exposure time was set to 1 min. (b) Influence of UV exposure time on drug release. The gridline object was used for this experiment. The data represent the mean SD (n = 3).

These results indicate that CMC is useful for adjusting the properties of printer ink and is a useful and safe pharmaceutical excipient in drug formulations. We also showed that drug release from 3D-printed patches was dependent on the patch shapes and UV exposure time, and that drug release can be controlled. Taken together, the present results provide useful information for the preparation of 3D printed objects containing liposomes and other nanoparticle-based nanomedicines, concluded the authors.

Originally posted here:
3D Printed Medicine Uses Fish Gelatin to Deliver Cancer Treatment - 3DPrint.com

Growing at a steady pace, this Healthcare Nanotechnology (Nanomedicine) market research values the industry size in USD million terms for 2020 and expected USD million value by the end of 2025 is provided for decision makers and stakeholders interested in Healthcare Nanotechnology (Nanomedicine) market. The report on Healthcare Nanotechnology (Nanomedicine) market provides qualitative as well as quantitative analysis in terms of market dynamics, competition scenarios, opportunity analysis, market growth, industrial chain, etc.

The Healthcare Nanotechnology (Nanomedicine) market research report provides a thorough analysis regarding the production and the consumption patterns of this industry vertical. Based on production aspect, the study offers crucial insights pertaining to the manufacturing patterns of the items, revenue share, and its respective impact on the overall gross margins of the producers.

As per consumption patterns, the document assesses the consumption value and volume regarding each of the product offerings, their sale prices and import & export conditions across various regions listed. Additionally, the report also delivers production and consumption expectations, during the ongoing COVID-19 pandemic.

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Emphasizing on the regional landscape:

Summarizing the product landscape:

Elaborating on the application space:

Highlighting the competitive dynamics:

Briefly, the Healthcare Nanotechnology (Nanomedicine) market research report comprises of a granular assessment regarding the upstream raw materials, downstream buyers, manufacturing equipment and distribution channels. Furthermore, it evaluates the various market dynamics such as opportunities, trends, drivers and limitations & challenges which are impacting the revenue generation of the overall market.

Key Questions Answered in Global Healthcare Nanotechnology (Nanomedicine) market Report: -

The Report Provides The Following Information:

Categorize data at the regional level as well as revenue and growth of in these regions

Distribution channels, and consumption patterns, of the global Healthcare Nanotechnology (Nanomedicine) market

Study data of the market on the basis of the country, including market share and revenue of the important countries

Critical analysis of every market player, such as collaborations, acquisitions, and product launches

Market opportunities, challenges, and threats faced by the vendors in the global Healthcare Nanotechnology (Nanomedicine) market are highlighted

Upstream raw materials and manufacturing equipment are investigated.

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Global Healthcare Nanotechnology (Nanomedicine) Market Analysis, Size, Share, Growth, Trends and Forecast to 2025 - Express Journal

Nanomedicine Market has witnessed continuous growth within the past few years and is projected to grow even more throughout the forecast period (2020 2027). The analysis presents a whole assessment of the market and contains Future trends, Current Growth Factors, attentive opinions, facts, historical information, and statistically supported and trade valid market information.

The report, titled Global Nanomedicine Market defines and briefs readers about its products, applications, and specifications. The research lists key companies operating in the global market and also highlights the key changing trends adopted by the companies to maintain their dominance. By using SWOT analysis and Porters five force analysis tools, the strengths, weaknesses, opportunities, and threats of key companies are all mentioned in the report. All leading players in this global market are profiled with details such as product types, business overview, sales, manufacturing base, competitors, applications, and specifications.

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GE Healthcare, Johnson & Johnson, Mallinckrodt plc, Merck & Co. Inc., Nanosphere Inc., Pfizer Inc., Sigma-Tau Pharmaceuticals Inc., Smith & Nephew PLC, Stryker Corp, Teva Pharmaceutical Industries Ltd., UCB (Union chimique belge) S.A of the major organizations dominating the global market.(*Note: Other Players Can be Added per Request)

1. Industry outlookThis is where youll find the current state of the Nanomedicine industry overall and where its headed. Relevant industry metrics like size, trends, life cycle, and projected growth included here. This report comes prepared with the data to back up your business idea. On a regional basis, the Global Nanomedicine market has been segmented into Asia-Pacific, North America, Europe, Latin America, and the Middle East and Africa.

2. Target marketThis target market section of study includes the following:

User persona and characteristics: It includes demographics such as age, income, and location. It lets you know what their interests and buying habits are, as well as explain the best position to meet their needs.

Market size: How big is the potential Nanomedicine market for your business? It brings to light the consumption in the Nanomedicine industry by the type and application.

3. Competitive analysisDiscover your competitors. The report lets you know what youre up against, but it also lets you spot the competitions weaknesses. Are there customers that are underserved? What can you offer that similar businesses arent offering? The competitive analysis contains the following components:

Direct competitors: What other companies are offering similar products and services? Which companies are your true competitors?

Competitor strengths and weaknesses: What is your competition good at? Where do they fall behind? Get insights to spot opportunities to excel where others are falling short.

Barriers to entry: What are the potential pitfalls of entering the Nanomedicine market? Whats the cost of entry? Is it prohibitively high, or easy to enter?

The window of opportunity:Does your entry into the Nanomedicine industry rely on time-sensitive technology? Do you need to enter early to take advantage of an emerging market?

4. ProjectionsLikewise, We offered thoughtful, not hockey-stick forecasting.

Market share:We have given the consumption behavior of users. When you know how much can your future customers spend, then only youll understand how much of the Nanomedicine industry you have a chance to grab, and here we came up with real stats and numbers.

Impact Analysis of COVID-19:The complete version of the Report will include the impact of the COVID-19, and anticipated change on the future outlook of the industry, by taking into account the political, economic, social, and technological parameters.

Finally, It is one report that hasnt shied away from taking a critical look at the current status and future outlook for the consumption/sales of these products, by the end users and applications. Not forgetting the market share control and growth rate of the Nanomedicine Industry, per application. Most noteworthy, this market analysis will help you find market blind spots.

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Nanomedicine Market: Opportunities After COVID 19 That Will Help to Increase Revenue GE Healthcare, Johnson & Johnson, Mallinckrodt plc - Market...

Healthcare Nanotechnology Market Forecast 2020-2026

The Global Healthcare Nanotechnology Market research report provides and in-depth analysis on industry- and economy-wide database for business management that could potentially offer development and profitability for players in this market. This is a latest report, covering the current COVID-19 impact on the market. The pandemic of Coronavirus (COVID-19) has affected every aspect of life globally. This has brought along several changes in market conditions. The rapidly changing market scenario and initial and future assessment of the impact is covered in the report. It offers critical information pertaining to the current and future growth of the market. It focuses on technologies, volume, and materials in, and in-depth analysis of the market. The study has a section dedicated for profiling key companies in the market along with the market shares they hold.

The report consists of trends that are anticipated to impact the growth of the Healthcare Nanotechnology Market during the forecast period between 2020 and 2026. Evaluation of these trends is included in the report, along with their product innovations.

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The Report Covers the Following Companies:AmgenTeva PharmaceuticalsAbbottUCBRocheCelgeneSanofiMerck & CoBiogenStrykerGilead SciencesPfizer3M CompanyJohnson & JohnsonSmith & NephewLeadiant BiosciencesKyowa Hakko KirinTakedaIpsenEndo InternationalHealthcare Nanotechnolog

By Types:NanomedicineNano Medical DevicesNano DiagnosisOthersHealthcare Nanotechnolog

By Applications:AnticancerCNS ProductAnti-infectiveOthers

Furthermore, the report includes growth rate of the global market, consumption tables, facts, figures, and statistics of key segments.

By Regions:

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Years Considered to Estimate the Market Size:History Year: 2015-2019Base Year: 2019Estimated Year: 2020Forecast Year: 2020-2026

Important Facts about Healthcare Nanotechnology Market Report:

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Healthcare Nanotechnology Market (2020-2026) | Where Should Participant Focus To Gain Maximum ROI | Exclusive Report By Industry Growth Insights -...

Nanorobotics Market Overview 2020 2025

This has brought along several changes in This report also covers the impact of COVID-19 on the global market.

The risingtechnology in Nanorobotics Marketis also depicted in thisresearchreport. Factors that are boosting the growth of the market, and giving a positive push to thrive in the global market is explained in detail.

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Key Competitors of the Global Nanorobotics Market are: , Bruker, JEOL, Thermo Fisher Scientific, Ginkgo Bioworks, Oxford Instruments, EV Group, Imina Technologies, Toronto Nano Instrumentation, Klocke Nanotechnik, Kleindiek Nanotechnik,

Historical data available in the report elaborates on the development of the Nanorobotics on national, regional and international levels. Nanorobotics Market Research Report presents a detailed analysis based on the thorough research of the overall market, particularly on questions that border on the market size, growth scenario, potential opportunities, operation landscape, trend analysis, and competitive analysis.

Major Product Types covered are: , Nanomanipulator, Bio-Nanorobotics, Magnetically Guided, Bacteria-Based,

Major Applications of Nanorobotics covered are: , Nanomedicine, Biomedical, Mechanical,

This study report on global Nanorobotics market throws light on the crucial trends and dynamics impacting the development of the market, including the restraints, drivers, and opportunities.

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The fundamental purpose of Nanorobotics Market report is to provide a correct and strategic analysis of the Nanorobotics industry. The report scrutinizes each segment and sub-segments presents before you a 360-degree view of the said market.

Market Scenario:

The report further highlights the development trends in the global Nanorobotics market. Factors that are driving the market growth and fueling its segments are also analyzed in the report. The report also highlights on its applications, types, deployments, components, developments of this market.

Highlights following key factors:

:-Business descriptionA detailed description of the companys operations and business divisions.:-Corporate strategyAnalysts summarization of the companys business strategy.:-SWOT AnalysisA detailed analysis of the companys strengths, weakness, opportunities and threats.:-Company historyProgression of key events associated with the company.:-Major products and servicesA list of major products, services and brands of the company.:-Key competitorsA list of key competitors to the company.:-Important locations and subsidiariesA list and contact details of key locations and subsidiaries of the company.:-Detailed financial ratios for the past five yearsThe latest financial ratios derived from the annual financial statements published by the company with 5 years history.

Our report offers:

Market share assessments for the regional and country level segments. Market share analysis of the top industry players. Strategic recommendations for the new entrants. Market forecasts for a minimum of 9 years of all the mentioned segments, sub segments and the regional markets. Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations). Strategic recommendations in key business segments based on the market estimations. Competitive landscaping mapping the key common trends. Company profiling with detailed strategies, financials, and recent developments. Supply chain trends mapping the latest technological advancements.

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New Comprehensive Report on Nanorobotics Market to Witness an Outstanding Growth during 2020 2025 with Top Players Like - 3rd Watch News

Nanorobots Market Overview 2020 2025

This has brought along several changes in This report also covers the impact of COVID-19 on the global market.

The risingtechnology in Nanorobots Marketis also depicted in thisresearchreport. Factors that are boosting the growth of the market, and giving a positive push to thrive in the global market is explained in detail.

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Key Competitors of the Global Nanorobots Market are: , Bruker, Jeol, Thermo Fisher, Ginkgo Bioworks, Oxford Instruments, Ev Group, Imina Technologies, Toronto Nano Instrumentation, Klocke Nanotechnik, Kleindiek Nanotechnik, Xidex, Synthace, Park Systems, Smaract, Nanonics Imaging, Novascan Technologies, Angstrom Advanced, Hummingbird Scientific, Nt-Mdt Spectrum Instruments, Witec,

Historical data available in the report elaborates on the development of the Nanorobots on national, regional and international levels. Nanorobots Market Research Report presents a detailed analysis based on the thorough research of the overall market, particularly on questions that border on the market size, growth scenario, potential opportunities, operation landscape, trend analysis, and competitive analysis.

Major Product Types covered are: , Nanomanipulator, Bio-Nanorobotics, Magnetically Guided, Bacteria-Based,

Major Applications of Nanorobots covered are: , Nanomedicine, Biomedical, Others,

This study report on global Nanorobots market throws light on the crucial trends and dynamics impacting the development of the market, including the restraints, drivers, and opportunities.

To get this report at a profitable rate.: https://reportsinsights.com/discount/20676

The fundamental purpose of Nanorobots Market report is to provide a correct and strategic analysis of the Nanorobots industry. The report scrutinizes each segment and sub-segments presents before you a 360-degree view of the said market.

Market Scenario:

The report further highlights the development trends in the global Nanorobots market. Factors that are driving the market growth and fueling its segments are also analyzed in the report. The report also highlights on its applications, types, deployments, components, developments of this market.

Highlights following key factors:

:-Business descriptionA detailed description of the companys operations and business divisions.:-Corporate strategyAnalysts summarization of the companys business strategy.:-SWOT AnalysisA detailed analysis of the companys strengths, weakness, opportunities and threats.:-Company historyProgression of key events associated with the company.:-Major products and servicesA list of major products, services and brands of the company.:-Key competitorsA list of key competitors to the company.:-Important locations and subsidiariesA list and contact details of key locations and subsidiaries of the company.:-Detailed financial ratios for the past five yearsThe latest financial ratios derived from the annual financial statements published by the company with 5 years history.

Our report offers:

Market share assessments for the regional and country level segments. Market share analysis of the top industry players. Strategic recommendations for the new entrants. Market forecasts for a minimum of 9 years of all the mentioned segments, sub segments and the regional markets. Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations). Strategic recommendations in key business segments based on the market estimations. Competitive landscaping mapping the key common trends. Company profiling with detailed strategies, financials, and recent developments. Supply chain trends mapping the latest technological advancements.

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COVID-19 Impact: Nanorobots Market | Strategic Industry Evolutionary Analysis Focus on Leading Key Players and Revenue Growth Analysis by Forecast To...

VALENCIA, Calif. & MELBOURNE, Australia--(BUSINESS WIRE)--AVITA Therapeutics, Inc. (NASDAQ: RCEL, ASX:AVH), a regenerative medicine company that is developing and commercializing a technology platform that enables point-of-care autologous skin restoration for multiple unmet needs, announced today preliminary unaudited results for the fourth quarter and full year ended June 30, 2020, together with a company update.

Preliminary Unaudited Results for Three Month Period Ended June 30, 2020

With effect from July 1, 2020, the Company is reporting financial results in United States dollars (US$), and prepared in accordance with U.S. Generally Accepted Accounting Principles (U.S. GAAP).

To compare with the Companys previously reported results (as reported under IFRS) fourth quarter net revenue was approximately A$6.08M, versus A$5.96M in the third quarter, or an increase of 2.0%.

We are pleased with our fourth quarter results given the challenges and limited patient and facility access that we have experienced with the onset of the COVID-19 pandemic, said Dr. Mike Perry, AVITA Therapeutics Chief Executive Officer. Like many others, this quarter we witnessed the most challenging commercial conditions since the RECELL System was launched in the U.S. in early 2019. While burns are not considered elective procedures, the incidence of burns was not immune to the impact of COVID-19 as nationwide protective (executive) orders drove a reduction in accidents resulting in burn injuries. Despite the tough macro environment, the clear benefits of the RECELL System including shortened length of hospital stays, together with less invasive and fewer surgeries, continues to resonate with hospitals, physicians, and patients, which is reflected in our results this quarter.

Preliminary Unaudited Results for the Full Year Ended June 30, 2020

To compare with the Companys previously reported results (as reported under IFRS) fiscal 2020 sales were approximately A$21.72M, an increase of A$14.02M or 182% over the A$7.71M recognized during the previous full year.

To compare with the Companys previously reported results (as reported under IFRS) fiscal 2020 sales were approximately A$21.03M, an increase of A$14.82M or 238% over the A$6.21M recognized during the previous full year.

Company Update

Quarter Ended June 30, 2020

During the fourth quarter we witnessed a wide degree of variability with both revenue and procedural volumes, together with an environment where our customers mandated highly restrictive access practices for our field force given the COVID-19 pandemic. Face-to-face interaction with our burn caregivers continues to be exclusively at physician request for case support within the operating theater only, and does not permit participation in the aftercare setting or otherwise enable clinical and business development, for example, to expand utilization of the RECELL System across different burns and users. Given the current state of affairs, we have no reason to believe that these measures, and our limited access, will change in the short term.

As previously stated, burn procedures are neither elective nor deferrable, however the rate of occurrence of these events is very dependent on broader economic activity and people movement. As such, we saw many of our customers initially experience reduced burn volumes due to the social distancing and shelter-in-place restrictions that have been implemented across the nation.

The reprioritization of hospital resources to support COVID-19 readiness meant that our April results were the lowest monthly revenue and procedural volumes seen this calendar year. Fortunately, as the quarter developed, the benefits of the RECELL System providing reduced hospital stays, and fewer and smaller surgeries, together with both a gradual uptick in burn incidence and hospitals (partially) reverting back from a COVID-19 centric focus, enabled a recovery of both revenue and procedural volume growth through May and June. As with many companies in the current pandemic environment, it is difficult to predict revenue and procedural volume over the coming months, but we are pleased with current utilization rates and our physician commitment.

BARDA

The Company continues to work with the U.S. Biomedical Advanced Research and Development Authority (BARDA) on the procurement of the RECELL System for the U.S. strategic national stockpile for public health medical emergencies (with an estimated contract value of US$7.6 million). The Company is hopeful of providing further updates on this topic during this quarter.

Future Market Opportunities

Set out below is an update on our various future market opportunities:

On July 1, 2020, the FDA approved the IDE application for the pivotal study which is titled A Prospective Multi-Arm Blinded-Evaluator Within-Subject Randomized Controlled Clinical Study to Investigate the Safety and Effectiveness of RECELL for Repigmentation of Stable Vitiligo.

The Company is continuing to work with FDA to finalize two (2) outstanding study design considerations and will provide further updates, including details regarding the study and initiation plan, over the next several weeks.

The Company expects to commence enrollment in the vitiligo pivotal study in the second half of this calendar year.

The Company continues to have a high degree of confidence that the RECELL System can be an effective therapeutic offering for patients with stable vitiligo. More than 1,000 patients have been treated with the RECELL System for vitiligo outside of the United States, and to date there are eight (8) publications demonstrating the benefits of the RECELL System in vitiligo.

By comparison, since October 1, 2019 the Company has benefited from various reimbursement codes for patients admitted for burn treatment in the inpatient hospital setting (under the Hospital Inpatient Prospective Payment System (IPPS)), including the following:

Medicare reimburses hospitals for inpatient services using MS-DRGs (Medicare Severity Diagnosis-Related Groups) (see MS-DRG 927, 928 and 929 for various types of burns (which are non-specific to the RECELL System)).

Specific ICD-10-PCS code series describing our cell suspension technique for the use of the RECELL System (see the OHR codes within ICD-10-PCS). These procedure codes are assigned to the same DRGs for payment as other skin grafts.

Current Procedural Terminology (CPT) for physicians to support reimbursement for physician rendered healthcare services.

There is no procedure-specific CPT code for the RECELL Systems cell suspension autografting and so, per recommendations from the American Burn Association, providers using the RECELL System are guided to the existing long-standing epidermal autografting codes (e.g. CPT code 151101 and 15115)2.

In the outpatient setting, the Company has been seeking a New Technology Ambulatory Payment Classification (APC) under the Outpatient Prospective Payment System (OPPS) since late 2019. However, based on feedback from The Centers for Medicare & Medicaid Services (CMS) and given recent changes to the OPPS payments system discussed below, the Company will now instead pursue a Transitional Pass-through Payment Application (TPT) to support separate additional Medicare payment for the RECELL System.

CMS has advised the Company that the availability of the long-standing CPT code 15110 and CPT code 15115 (which providers may presently utilize in both the inpatient and outpatient hospital setting) excludes our ability to apply for a New Technology APC for use in the outpatient setting.

On January 1, 2020, CMS implemented changes to the OPPS and ambulatory surgical centers (ASC) payment systems to permit medical devices, including the RECELL System, that have received FDA marketing authorization and are part of the Breakthrough Devices Program [to] be approved [by CMS for TPT] through the quarterly [review] process (as opposed to the typical annual review process).

TPT was established by CMS to provide an alternative payment pathway for transformative medical devices. Similar to the New Technology APC, if approved CMS would create a new C code and would allow the RECELL System to be billed and paid separately in hospital outpatient facilities and ASCs.

As a recipient of Breakthrough Device status, AVITA Therapeutics will work with CMS through the next CMS scheduled quarterly review cycle and is hopeful of having a C code in place for the RECELL System on January 1, 2021 (which should not change our current commercialization timeline for the outpatient hospital setting).

Enrollment of clinical studies across the United States are largely paused at present and the Companys enrollment of the aforementioned studies are accordingly largely on hold.

The Company has enrolled three (3) patients in the pediatric scald study and one (1) patient in the soft tissue reconstruction study.

The Company anticipates that enrollment will resume in the ensuing quarter.

Publications

Notable publications released during the quarter were as follows:

Japan

AVITA Therapeutics continues to work with our Japanese marketing partner, COSMOTEC, to advance our application for approval to market the RECELL System in Japan pursuant to Japans Pharmaceuticals and Medical Devices Act. The application has been constructed broadly to seek approval for the treatment of patients with burns, chronic wounds and vitiligo in three (3) size configurations of the RECELL System.

Progress on the application has been delayed due to the COVID-19 pandemic and the associated State of Emergency declaration in Japan. In addition, Japans regulatory agency, the Pharmaceuticals and Medical Devices Agency (PMDA), has now requested various non-clinical raw data (e.g., original hand written copies of data entry forms or records) of a small subset of our historic studies, some of which were conducted more than ten (10) years ago. To facilitate PDMAs request, AVITA Therapeutics is repeating three (3) non-clinical or benchtop tests. These tests are expected to be completed and submitted in August, and the Company hopes to then advance our application for approval of the RECELL System in Japan.

Other Updates

Authorized for release by the Chief Executive Officer of Avita Therapeutics, Inc.

ABOUT AVITA THERAPEUTICS, INC.

AVITA Therapeutics is a regenerative medicine company with a technology platform positioned to address unmet medical needs in burns, chronic wounds, and aesthetics indications. AVITA Therapeutics patented and proprietary collection and application technology provides innovative treatment solutions derived from the regenerative properties of a patients own skin. The medical devices work by preparing a RES REGENERATIVE EPIDERMAL SUSPENSION, an autologous suspension comprised of the patients skin cells necessary to regenerate natural healthy epidermis. This autologous suspension is then sprayed onto the areas of the patient requiring treatment.

AVITA Therapeutics first U.S. product, the RECELL System, was approved by the U.S. Food and Drug Administration (FDA) in September 2018. The RECELL System is indicated for use in the treatment of acute thermal burns in patients 18 years and older. The RECELL System is used to prepare Spray-On Skin Cells using a small amount of a patients own skin, providing a new way to treat severe burns, while significantly reducing the amount of donor skin required. The RECELL System is designed to be used at the point of care alone or in combination with autografts depending on the depth of the burn injury. Compelling data from randomized, controlled clinical trials conducted at major U.S. burn centers and real-world use in more than 8,000 patients globally, reinforce that the RECELL System is a significant advancement over the current standard of care for burn patients and offers benefits in clinical outcomes and cost savings. Healthcare professionals should read the INSTRUCTIONS FOR USE - RECELL Autologous Cell Harvesting Device (https://recellsystem.com/) for a full description of indications for use and important safety information including contraindications, warnings and precautions.

In international markets, our products are marketed under the RECELL System brand to promote skin healing in a wide range of applications including burns, chronic wounds and aesthetics. The RECELL System is TGA-registered in Australia and received CE-mark approval in Europe.

To learn more, visit http://www.avitamedical.com.

CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS

This letter includes forward-looking statements. These forward-looking statements generally can be identified by the use of words such as anticipate, expect, intend, could, may, will, believe, estimate, look forward, forecast, goal, target, project, continue, outlook, guidance, future, other words of similar meaning and the use of future dates. Forward-looking statements in this letter include, but are not limited to, statements concerning, among other things, our ongoing clinical trials and product development activities, regulatory approval of our products, the potential for future growth in our business, and our ability to achieve our key strategic, operational and financial goal. Forward-looking statements by their nature address matters that are, to different degrees, uncertain. Each forward- looking statement contained in this letter is subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statement. Applicable risks and uncertainties include, among others, the timing of regulatory approvals of our products; physician acceptance, endorsement, and use of our products; failure to achieve the anticipated benefits from approval of our products; the effect of regulatory actions; product liability claims; risks associated with international operations and expansion; and other business effects, including the effects of industry, economic or political conditions outside of the companys control. Investors should not place considerable reliance on the forward-looking statements contained in this letter. Investors are encouraged to read our publicly available filings for a discussion of these and other risks and uncertainties. The forward-looking statements in this letter speak only as of the date of this release, and we undertake no obligation to update or revise any of these statements.

1 CPT code 15110: Epidermal autograft, trunks, arms, legs; CPT code 15115: Epidermal autograft, face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and / or multiple digits.2 It should be noted that the CPT code may be used in both the inpatient and the outpatient hospital setting.

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AVITA Therapeutics Provides Company Update and Preliminary Unaudited Results for the Fourth Quarter and Fiscal Year 2020 - Business Wire

In our new financial reality, our state and you as voters are faced with tough decisions. Come November, you will decide the fate of Californias stem cell institute. This decision has never been more important to the future of Californias health care, for the patients and their families, than it is now.

Californians overwhelmingly approved the states first stem cell initiative in 2004, with nearly 60% of the vote, and widespread support from patient advocacy organizations, labor, business and elected officials. The 2004 initiative established the California Institute for Regenerative Medicine (CIRM) to fund medical research and the development of new treatments and cures.

If Californians do not pass Proposition 14, vital lifesaving research will come to a halt.

CIRM funding has advanced research and therapy development for more than 75 different diseases and conditions, more than 90 clinical trials, more than 1,000 medical projects at 70 institutions across California and nearly 3,000 published medical discoveries. This investment has already saved and improved lives, including a high school student who was paralyzed in a diving accident and was able to regain function in his upper body and go on to college, a mother who went blind from a genetic disease has had some of her eyesight restored, two FDA-approved cancer treatments are already saving lives, and many more.

As funding for Californias stem cell research program has now run out, Californians have a critical opportunity to pass the 2020 stem cell initiative Proposition 14 to continue to advance lifesaving research and treatment development. Proposition 14 just recently qualified for the November ballot with early support from more than 65 patient advocacy organizations, the University of California and Nobel Prize winners.

If Californians do not pass Proposition 14, vital lifesaving research will come to a halt. Medical discoveries wont be able to progress to clinical trials, delaying lifesaving and life-changing treatments for cancer, diabetes, heart disease, Alzheimers, Parkinsons, infectious diseases like COVID-19 and more for years or decades.

Additionally, not passing Proposition 14 would eliminate a critical economic and jobs stimulus for our state.

Arguably, our state leaders are rightfully concerned about the state budget amid the current landscape. But as we enter a period of economic crisis, this bond measure will act as an economic recovery and jobs stimulus.

It is not a tax; it is a general obligation bond that will be repaid by the state, over decades, beginning in 2026.

Proposition 14 will increase the amount of state funds available to tackle other issues for the next 10 years by increasing state tax revenues through 2030 potentially providing more state revenue than the cost of bond payments during that time. To date, Californias stem cell research program has generated $10.7 billion in increased state economic activity and hundreds of millions in additional state revenues. Californias stem cell research program also creates tens of thousands of jobs at every level from lab technicians and maintenance workers to nurses and physicians.

Proposition 14 is exactly the kind of long-term investment we should make now to rebuild our economy. The initiative was specifically designed to be fiscally responsible. It is not a tax; it is a general obligation bond that will be repaid by the state, over decades, beginning in 2026 a full five years after its passage.

We cant afford not to fund Proposition 14.

Chronic diseases are the leading cause of death and the leading driver of annual health care spending and bankruptcies. In California alone, more than 30% of the states budget is spent on health care. With this cost rising every year, it is a growing strain on California families and our state budget.

If we hesitate to fund proper research to develop cures for chronic illnesses, our health care costs will financially drain California families, as well as our struggling state budget. Reducing the cost of treating just 6 of 80 major chronic diseases or injuries by 1-2% would pay for the Initiative twice over.

The decision you make in November will have lasting impacts on the state funds available to tackle priorities California needs to address now, and in the future, including housing, education, or the environment. Proposition 14 will generate additional revenue to help address these issues now, and potentially save California tens of billions for the future.

Proposition 14 will cost the state an average of less than $5 per person, per year about the cost of a bottle of aspirin. That is a small price to pay to potentially save millions of lives and tens of billions of dollars in health care costs in the coming decades. At the end of the day, Proposition 14 could save your life or the life of someone you love how can we afford not to make this investment?Editors Note: Bob Klein is chairman of Californians for Stem Cell Research, Treatments and Cures.

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Stem cell initiative: Save lives and energize the economy - Capitol Weekly

Wound care products include dressings and bandages and play an imperative role in assisting in medical cases in hospitals and clinics. They offer the first line of treatment to patients and have induced a massive demand due to increase in chronic and acute disorders. The global wound care market report prepared by analysts at Market Research Future (MRFR) contains insightful trends and drivers which can make industry leaders in making sizeable decisions for the future.

Wound Care Market Overview

The global wound care market size is touted to exceed a value of USD 29,900 million by 2027. It stood at USD 15,456.2 million in 2016. It is expected to experience an enjoyable run over the period of 2017 to 2027 (forecast period) due to high prevalence of chronic injuries. Emphasis on patient care is likely to trigger the development of new variants of existing products and bolster the market demand till the end of the forecast period. Rise of the general populace and favorable reimbursement policies can work in favor of the market.

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Rise in the number of surgeries, increase in accident rates, and high number of burn cases are factors which can drive market growth. The increase in the numbers of the geriatric populace is one of the biggest drivers of the global wound care market. The use of wound care products for expediting the healing of scars and small injuries can bode well for the market revenue. Inclination of patients towards these products can boost the global market volume till 2027.

Wound Care Market Segmentation

The global Wound Care Market report is segmented on the basis of product, type, application, and end-user.

By product, it is segmented into wound care products, traditional wound care products, active wound care products, wound therapy devices, and advanced wound management products. The advanced wound management products segment accounted for close to 31% share in 2016. The use of these products in the treatment of acute and chronic wounds can bolster the market share of the segment by 2027. On the other hand, traditional wound care products can gain a larger market share due to its inexpensive nature and easy availability.

By type, it is segmented into acute and chronic wound. The chronic wound segment accounted for 60.3% share in 2016.

By application, it is segmented into trauma wounds, surgical wound, burn, and ulcer. The surgical wound segment is the biggest application of the market due to its use in the treatment of grievous injuries. It accounted for 35% market share in 2016. On the other hand, the ulcer segment accounted for 22.1% share in the same year.

By end-user, it is segmented into trauma centers, home healthcare, clinics, and hospitals. Hospitals accounted for 37.5% share in 2016, while clinics accounted for 26% share in the same year. Improved patient care in hospitals can drive the market demand for the segment exponentially till 2027.

Wound Care Market Regional Analysis

The Middle East & Africa (MEA), North America, Latin America, Asia Pacific (APAC), and Europe are the regions become the centerpoint in the global wound care market report.

North America is likely to dominate the global market till the end of the forecast timespan due to the large diabetic population. The high healthcare expenditure and investments by hospitals and clinics to improve their current healthcare services can drive the regional market growth. The U.S. is one of the biggest contributors to the regional market revenue due to a sophisticated healthcare framework and a large patient pool.

The APAC region is anticipated to exhibit a CAGR exceeding 6% during the forecast timespan due to large number of chronic diseases, large geriatric populace, and rising incidence of chronic wounds.

Wound Care Market Competition Outlook

Some of the key players profiled in the market report include CanvaTec, Kinetic Concepts, Inc., Smith & Nephew, Ethican, Inc., B. Braun Melsungen AG, 3M, and Baxter. Mergers, acquisitions, and collaborations are major strategies being employed by these players to gain a significant edge in the market. Recently, 3M decided to acquire Acelity Inc. for USD 6.7 billion. This would considerably extend the product offering list of the former and cater to a large number of clients.

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About Market Research Future:

At Market Research Future (MRFR), we enable our customers to unravel the complexity of various industries through our Cooked Research Report (CRR), Half-Cooked Research Reports (HCRR), Raw Research Reports (3R), Continuous-Feed Research (CFR), and Market Research & Consulting Services.

MRFR team have supreme objective to provide the optimum quality market research and intelligence services to our clients. Our market research studies by Components, Application, Logistics and market players for global, regional, and country level market segments, enable our clients to see more, know more, and do more, which help to answer all their most important questions.

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Applications in Regenerative Medicine to Expand Global Wound Care Market Opportunities till 2027 - Cole of Duty