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Free diabetes, nutrition program offered through Zoom – PenBayPilot.com

July 9th, 2020 8:49 pm

Spectrum Generations in partnership with Healthy Living for ME will be offering a free workshop to help individuals with diabetes, prediabetes, their caregivers or family members. Living Well with Diabetes will be offered beginning Monday, August 13 and running through September 17. Workshops participants will meet weekly from 9:30 - 11:30 a.m.

Topics such as testing your blood sugar, menu planning, stress management, increasing activity level, treating low blood sugar, caring for your feet, and healthy eating will be discussed.

This series is free and open to the public but registration is required. Please call (207) 620-1642 or emailjpaquet@healthylivingforme.orgfor more information and to register. Technical support is available.

Healthy Living for ME is a statewide network of evidence-based programs that empower adults to address and better manage their health issues. All workshops are listed athealthylivingforme.org.

About Spectrum GenerationsSpectrum Generations, the Central Maine Area Agency on Aging and Aging and Disability Resource Center, has been a leading provider of information and advice, referrals, programs and activities for adults for over 30 years. Todays Spectrum Generations is poised to serve adults of all ages and backgrounds in a changing, challenging world. We are here for you as you look forward to longer, more active lives and seek to engage in new physical and intellectual challenges.

About Healthy Living for MEHealthy Living for ME brings together Spectrum Generations, SeniorsPlus, and Aroostook Agency on Aging three of Maines Area Agencies on Aging in a partnership to deliver statewide chronic disease self-management and falls prevention classes. FMI or to find a class, visit:healthylivingforme.orgor on Facebook @HLforME

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Diabetes diet management: Here are 7 foods with high GI that diabetics must avoid to balance blood sugar – Times Now

July 9th, 2020 8:49 pm

Diabetes diet management: Here are 7 foods with high GI that diabetics must avoid to balance blood sugar  |  Photo Credit: iStock Images

New Delhi: Diabetes has already reached epidemic levels around the world. With a rise in chronic diseases such as heart health issues, kidney diseases, and diabetes, it becomes extremely important to take care of what we eat. People who already suffer from diabetes not only need to keep a regular check on their blood sugar, but also need to be very mindful of what they need, not just in terms of how many spoons of sugar they add to their tea or coffee, but also with respect to other properties of food, such as the Glycemic Index.

To determine the intensity of sweetness, and sugar content of foods, a unit called the Glycemic Index has been devised. The Glycemic Index is a relative ranking of carbohydrate in foods according to how they affect their blood sugar levels. GI is one of the most important considerations for diabetics when it comes to managing their diet. These GI values of 5 most common foods consumed by people worldwide, and how they are likely to affect blood sugar levels for diabetics can help diabetes manage their diet better.

Cutting off unnatural sources of sugar like crystalized sugar, syrup, etc from your diet is recommended to stay healthy, keep your weight in check. If you have diabetes, it is recommended to cut off all sources of sugar, especially processed and unnatural sources. However, natural sources of sugar are unlikely to harm your health, but being aware of their sugar content can help you manage your condition better.

Disclaimer: Tips and suggestions mentioned in the article are for general information purposes only and should not be construed as professional medical advice. Always consult your doctor or a professional healthcare provider if you have any specific questions about any medical matter.

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Add fruit, veggies and grains to diet to reduce type 2 diabetes risk – Outlook India

July 9th, 2020 8:49 pm

Add fruit, veggies and grains to diet to reduce type 2 diabetes risk

London, July 9 (IANS) Higher consumption of fruit, vegetables and whole-grain foods are associated with a lower risk of developing type 2 diabetes, say researchers.

The findings, published in the journal The BMJ, suggest that even a modest increase in consumption of these foods as part of a healthy diet could help prevent type 2 diabetes.

In the first study, a team of European researchers examined the association between blood levels of vitamin C and carotenoids (pigments found in colourful fruits and vegetables) with the risk of developing type 2 diabetes.

Vitamin C and carotenoid levels are more reliable indicators of fruit and vegetable intake than using dietary questionnaires.The research team compared 9,754 adults with new-onset type 2 diabetes to a group of 13,662 adults who remained free of diabetes.

The researchers calculate that every 66 grams per day increase in total fruit and vegetable intake was associated with a 25 per cent lower risk of developing type 2 diabetes.

In the second study, the research team used questionnaires to measure the whole grain intake of more than 158,000 women and nearly 37,000 men who were free from diabetes, heart disease and cancer.

After adjusting for lifestyle and dietary risk factors for diabetes, participants in the highest category for total whole grain consumption had a 29 per cent lower rate of type 2 diabetes compared with those in the lowest category.

For individual whole-grain foods, the researchers found that consuming one or more servings a day of whole-grain cold breakfast cereal or dark bread was associated with a lower risk of type 2 diabetes compared with consuming less than one serving a month.

The findings showed that eating two or more servings a week of oatmeal was associated with a 21 per cent lower risk of diabetes, a 15 per cent lower risk for added bran and a 12 per cent lower risk for brown rice and wheat germ, when compared to eating less than one serving a month.

And for fruit and vegetables, the findings also suggest that consumption of even a moderately increased amount among populations who typically consume low levels could help to prevent type 2 diabetes.

--IANS

bu/arm

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Three-quarters of Patients with Type 2 Diabetes Have Other Comorbidities – Medscape

July 9th, 2020 8:49 pm

According to a new population-based cohort study, over three-quarters of patients with type 2 diabetes (T2D) in England have at least one other physical or mental health condition. The findings were published in the journal BMJ Open .

Researchers compared 108,588 T2D patients with 528,667 individuals without T2D, registered in English general practices. They analysed the annual patterns of several physical and mental health conditions among individuals with and without T2D.

The findings showed that 77%of individuals with T2D had one or more physical or mental health comorbidity. Individuals with T2D had a 2.4-fold, 1.8-fold, 1.6-fold and 1.6-fold higher likelihood of having schizophrenia, depression, asthma and chronic obstructive pulmonary disease (COPD), respectively, compared with individuals without T2D. Individuals with T2D had twice the prevalence of cardiovascular disease than their non-T2D counterparts. Additionally, osteoarthritis, hypothyroidism and anxiety were also more prevalent in individuals with T2D.

The lead author, Dr Salwa Zghebi, said: "We highlight the need for future clinical guidelines in diabetes to refocus patient-centred care on non-cardiometabolic conditions such as asthma, COPD, anxiety, depression, schizophrenia, and osteoarthritis."

"Mental health is of particular concern and our data highlight a profound clinical need in young people with type 2 diabetes who might benefit enormously from mental health interventions," she added.

Zghebi SS, Steinke DT, Rutter MK, Ashcroft DM. Eleven-year multimorbidity burden among 637 255 people with and without type 2 diabetes: a population-based study using primary care and linked hospitalisation data. BMJ Open. 2020;10(7):e033866. doi: 10.1136/bmjopen-2019-033866. PMID: 32611677. Full text.

This article originally appeared on Univadis, part of the Medscape Professional Network.

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Diabetic Food Market Size Predicted To Reach USD 11.76 Billion By 2025 | Grand View Research Inc. – MENAFN.COM

July 9th, 2020 8:49 pm

(MENAFN - GetNews) According to report published by Grand View Research, Growing awareness over diabetes coupled with preventive measures taken by consumers is anticipated to spur the market growth.

The global diabetic food market size is expected to reach USD 11.76 billion by 2025, according to a new report by Grand View Research, Inc. Rising demand for diabetic food in the medical sector is anticipated to fuel the market growth.

Diabetic Food is the diet which is recommended for individuals with high blood glucose or diabetes mellitus. It usually consists of edible products which are rich in refined carbohydrates and have low sugar content. Different individuals living with diabetes are recommended different types of diet based on their condition. In cases of hypoglycemia many are recommended to have a diet which increases their blood glucose level rapidly and in other cases, individuals suffering from diabetes mellitus are recommended to have a diet which reduces their high glycemic index (GI) carbohydrates intake.

Major technological shifts in the manufacturing processes and the use of advanced machinery are anticipated to positively affect the market growth. Many firms are investing in creating android and iPhone applications to help the individuals living with diabetes to better manage their health. These applications include BG Monitor Diabetes, Blue Loop, Calorie Counter PRO, Diabetes in Check and Diabetes Tracker. These applications help people to set reminders, create graphs and spreadsheets of their data, calculate their calorie intake, insulin requirements and track their progress.

The diabetic food industry is governed by various regulations that cover the entire lifecycle ranging from production to end use. Diabetic products used in the healthcare industry need to strictly abide by the stringent U.S. FDA regulations. Health disorders are a result of unhealthy lifestyles such as long working hours, sedentary lifestyle, smoking, poor food habits and alcohol consumption and are anticipated to influence the industry growth over the forecast period.

U.S. diabetic food market revenue by application, 2014 - 2025 (USD Million)

Request a sample Copy of the Diabetic Food Market Research Report @ https://www.grandviewresearch.com/industry-analysis/diabetic-food-market/request/rs1

Key Takeaways Of The Report :

The global diabetic food demand was USD 7 billion in 2015 and is estimated to grow at a CAGR of 5.4% from 2016 to 2025

Demand in dairy application is estimated to exceed USD 3 billion by 2025, owing to its probiotic properties

Baked products application segment is estimated to grow at a CAGR of 5.5% over the forecast period owing to the large demand of sugar-free baked products by health conscious consumers

Product demand in Asia Pacific is expected to grow at a significant rate of 6.0% over the next nine years owing to the emerging economies and the growing investment in the medical foods sector

Diabetic foodmarket in North America is anticipated to exceed USD 4 billion by 2025, owing to the growing medical sector and imbalance in work life and unhealthy lifestyle

Companies such as Coca-Cola Company and PepsiCo Inc. offer raw materials including, dietary syrups, carbon dioxide, sweeteners, and juices, to various industries including, frozen foods, nutritional and functional foods, beverages, medical and processed foods.

Business expansions by companies, such as Mondelz International to establish global research, development & quality (RDQ) network of the future, is anticipated to strengthen the market presence over the coming years

Have Any Query? Ask Our Experts @ https://www.grandviewresearch.com/inquiry/1906/ibb

Global diabetic food market revenue by region, 2015 (USD Million)

Grand View Research has segmented the global diabetic food market on the basis of product, application, and region:

Diabetic Food Market, Application Outlook (Revenue, USD Million, 2014 - 2025)

Diabetic Food Market, Regional Outlook (Revenue, USD Million, 2014 - 2025)

North America

Europe

Asia Pacific

CSA

MEA

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Media Contact Company Name: Grand View Research, Inc. Contact Person: Sherry James, Corporate Sales Specialist - U.S.A. Email: Send Email Phone: 1-415-349-0058, Toll Free: 1-888-202-9519 Address: 201, Spear Street, 1100 City: San Francisco State: California Country: United States Website: https://www.grandviewresearch.com/industry-analysis/diabetic-food-market

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Brewers’ Garrett Mitchell has unique perspective by living with type 1 diabetes – The Athletic

July 9th, 2020 8:49 pm

The fraternity of baseball players with type 1 diabetes isnt large. Its not unusual for someone to make a connection with someone else through a mutual friend within the group. Thats how former major-league outfielder Sam Fuld remembered getting in touch with Garrett Mitchell a few years ago.

Mitchell, 21, was in high school, a top outfield prospect preparing to attend UCLA, when he first heard from Fuld. One day, Fuld, whose eight-year playing career ended in 2015, phoned him. They shared stories. Fuld was diagnosed with type 1 diabetes when he was 10. Mitchell was 9 when he learned he had diabetes. Fuld offered advice. The two have maintained a relationship. Throughout it, Fuld has learned how well-equipped Mitchell is at handling the disease.

I was impressed with him right away, Fuld said. Just talking to him, he seemed like a mature kid back then. He certainly seemed to have a really good mindset, which is so key in...

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July: Diabetes Kathleen Gillespie | News and features – University of Bristol

July 9th, 2020 8:49 pm

JDRF, the world's leading type 1 diabetes charity, is partnering with Diabetes UK to find out how the coronavirus pandemic is affecting people with type 1 diabetes.

Whilst risk of death from COVID-19 is low, for people with and without type 1 diabetes, NHS figures nonetheless show the risk is higher for those with the condition.

Scientists dont know how many people with type 1 have had coronavirus and recovered, obscuring the full impact that the virus is having on the UKs 400,000 people with type 1.

Now, JDRF and Diabetes UK will co-fund Professor Kathleen Gillespie, at the University of Bristol, to find out.

Professor Gillespie's team will work with a research group in Milan that has developed a test that can detect coronavirus antibodies in a small sample of blood small enough to be collected via post.

By offering this test to around 5,000 people participating in ongoing studies of type 1 diabetes (the Barts Oxford study and UK TrialNet), Professor Gillespie will be able to estimate how many people contracted coronavirus.

She will also ask participants to share their experiences of COVID-19 and lockdown including whether they have been shielding, if they have had any COVID-19 symptoms, and how their blood glucose levels have reacted.

With this information, Professor Gillespie will be able to see how the type 1 diabetes community has been hit by COVID-19.

This will give scientists and clinicians a clearer idea of the risk that coronavirus poses to people with type 1, enabling healthcare teams to better support and protect people with the condition.

Kathleen Gillespie, Professor of Molecular Medicine at the University of Bristol, said: "Although we know that people with type 1 diabetes are at greater risk if they develop COVID-19, we know very little about how this translates to peoples experiences of the pandemic.

"With this research, we hope to get a much clearer idea of how the type 1 diabetes community has been affected by coronavirus, and how they can be kept safe and well in future."

Rachel Connor, Director of Research Partnerships at JDRF, said: "Everyone with type 1 diabetes is different, and Professor Gillespies work will shed some much-needed light on the individual experiences behind the statistics.

"Were hopeful that with this information, policymakers and healthcare teams will be able to give people with type 1 diabetes the advice and support they need."

Dr Elizabeth Robertson, Director of Research at Diabetes UK, said: "There's never an easy time to live with diabetes, but the COVID-19 pandemic presents particular challenges for people with type 1. It is vital that we understand how having COVID-19, as well as living in lockdown, affects people with type 1 diabetes so that we can provide them with the best advice and care during this difficult time and in the future.

"We're delighted to join forces with JDRF to fund Professor Gillespie's research, which will help us to do this by giving important insights into the experiences of people with type 1 diabetes during the pandemic."

About JDRF

JDRF is the leading global organisation funding type 1 diabetes research. Our mission is to accelerate life-changing breakthroughs to cure, prevent and treat type 1 diabetes and its complications. To accomplish this, JDRF has invested more than 1 billion since our inception. We collaborate with the most talented minds to develop and deliver a pipeline of innovative therapies to people living with type 1 diabetes. Our staff and volunteers around the globe are dedicated to campaigning for our vision of a world without type 1 diabetes.

For more information, please visit jdrf.org.uk or follow us on Twitter: @JDRFUK.

About type 1 diabetes

About the Bristol UNCOVER group

In response to the COVID-19 crisis, researchers at the University of Bristol formed the Bristol COVID Emergency Research (UNCOVER) Group to pool resources, capacities and research effortsto combat this infection.

BristolUNCOVER includes clinicians, immunologists, virologists, synthetic biologists, aerosol scientists, epidemiologists and mathematical modellers and has links to behavioural and social scientists, ethicists and lawyers and is supported by a large number of junior academic and administrative colleagues.

Follow Bristol UNCOVER on Twitter at:https://twitter.com/BristolUncover

For more information about the University of Bristols coronavirus (COVID-19) research priorities visit:www.bristol.ac.uk/research/impact/coronavirus/research-priorities/

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An analysis of diabetes mortality and morbidity risk – The Actuary

July 9th, 2020 8:49 pm

The past decade has seen significant advances in type 2 diabetes treatments, yet the long-term impact of these advances is not yet fully appreciated. The risk estimates currently available are derived from data that is more than 10 years old. The insurance industry underwrites customers with diabetes based on a range of factors, medical expertise and various medical studies.

The aim of this research project is to develop a deeper understanding of the risks associated with type 1 or type 2 diabetes, and the impact of recent improved treatments. It is hoped that this research will help the insurance industry appreciate and use current data and studies when considering diabetic risks, and ultimately could support individuals with diabetes to gain better access to insurance.

The call for tenders was issued on 1 June and organisations have until 12pm BST on 13 July to submit their proposals. This commissioned research will be overseen by a project steering group including representation from the IFoAs Diabetes Working Party and partner organisations. Independent academic guidance is also being provided by Cass Business School, City, University of London.

For further information onthis jointly commissioned ARC research project, please visitbit.ly/arcdiabetes

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Type 2 Diabetes Treatment Market Growth By Manufacturers, Countries, Types And Application, End Users And Forecast To 2026 – 3rd Watch News

July 9th, 2020 8:49 pm

New Jersey, United States,- Verified Market Research sheds light on the market scope, potential, and performance perspective of the Type 2 Diabetes Treatment Market by carrying out an extensive market analysis. Pivotal market aspects like market trends, the shift in customer preferences, fluctuating consumption, cost volatility, the product range available in the market, growth rate, drivers and constraints, financial standing, and challenges existing in the market are comprehensively evaluated to deduce their impact on the growth of the market in the coming years. The report also gives an industry-wide competitive analysis, highlighting the different market segments, individual market share of leading players, and the contemporary market scenario and the most vital elements to study while assessing the Type 2 Diabetes Treatment market.

The research study includes the latest updates about the COVID-19 impact on the Type 2 Diabetes Treatment sector. The outbreak has broadly influenced the global economic landscape. The report contains a complete breakdown of the current situation in the ever-evolving business sector and estimates the aftereffects of the outbreak on the overall economy.

Leading Type 2 Diabetes Treatment manufacturers/companies operating at both regional and global levels:

The report also inspects the financial standing of the leading companies, which includes gross profit, revenue generation, sales volume, sales revenue, manufacturing cost, individual growth rate, and other financial ratios.

Industrial Analysis:

The Type 2 Diabetes Treatment market report is extensively categorized into different product types and applications. The study has a separate section for explaining the cost of raw material and the revenue returns that are gained by the players of the market.

The segmentation included in the report is beneficial for readers to capitalize on the selection of appropriate segments for the Type 2 Diabetes Treatment sector and can help companies in deciphering the optimum business move to reach their desired business goals.

In Market Segmentation by Types of Type 2 Diabetes Treatment, the report covers-

Bytype1

In Market Segmentation by Applications of the Type 2 Diabetes Treatment, the report covers the following uses-

Byapplication1

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The Type 2 Diabetes Treatment market report provides successfully marked contemplated policy changes, favorable circumstances, industry news, developments, and trends. This information can help readers fortify their market position. It packs various parts of information gathered from secondary sources, including press releases, web, magazines, and journals as numbers, tables, pie-charts, and graphs. The information is verified and validated through primary interviews and questionnaires. The data on growth and trends focuses on new technologies, market capacities, raw materials, CAPEX cycle, and the dynamic structure of the Type 2 Diabetes Treatment market.

This study analyzes the growth of Type 2 Diabetes Treatment based on the present, past and futuristic data and will render complete information about the Type 2 Diabetes Treatment industry to the market-leading industry players that will guide the direction of the Type 2 Diabetes Treatment market through the forecast period. All of these players are analyzed in detail so as to get details concerning their recent announcements and partnerships, product/services, and investment strategies, among others.

Sales Forecast:

The report contains historical revenue and volume that backing information about the market capacity, and it helps to evaluate conjecture numbers for key areas in the Type 2 Diabetes Treatment market. Additionally, it includes a share of each segment of the Type 2 Diabetes Treatment market, giving methodical information about types and applications of the market.

Reasons for Buying Type 2 Diabetes Treatment Market Report

This report gives a forward-looking prospect of various factors driving or restraining market growth.

It renders an in-depth analysis for changing competitive dynamics.

It presents a detailed analysis of changing competition dynamics and puts you ahead of competitors.

It gives a six-year forecast evaluated on the basis of how the market is predicted to grow.

It assists in making informed business decisions by performing a pin-point analysis of market segments and by having complete insights of the Type 2 Diabetes Treatment market.

This report helps the readers understand key product segments and their future.

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In the end, the Type 2 Diabetes Treatment market is analyzed for revenue, sales, price, and gross margin. These points are examined for companies, types, applications, and regions.

To summarize, the Type 2 Diabetes Treatment market report studies the contemporary market to forecast the growth prospects, challenges, opportunities, risks, threats, and the trends observed in the market that can either propel or curtail the growth rate of the industry. The market factors impacting the global sector also include provincial trade policies, international trade disputes, entry barriers, and other regulatory restrictions.

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Opthalmology Pacs Market 2020 Growth Analysis, Current Demand, Research Study, Regions, Types and Key Companies Overview till 2025 – Market Research…

July 9th, 2020 8:48 pm

The global Opthalmology Pacs market covers a detailed analysis of the market appearances, segmentation, size and progress, market shares, provincial collapses, competitive background, tendencies and several growth strategies for this market. Likewise, the market appearances section of this study describes and defines the complete overview of the Opthalmology Pacs market. The global market report extent segment offers the market revenues, covering both the momentous growth of the industry and anticipating the upcoming market revenue. In addition, global market separations break down into the key sub-areas which gives a better idea about the market size.

Top Leading Key Players are:

Topcon Corporation, IBM corporation, Carl Zeiss Meditec AG, EyePACS, Heidelberg Engineering and more.

Get Sample Copy of this Report: https://www.adroitmarketresearch.com/contacts/request-sample/608

The report gives the description of the competitive landscape of the market, market dividends, and an explanation of the foremost companies. Momentous financial deals that have molded this industry in the previous years are also documented. The strategies tendencies also highlight the predictable future expansions in the Opthalmology Pacs market and commends approaches.

The Opthalmology Pacs market research report also covers the extensive SWOT analysis, venture return investigation, and speculation attainability investigation. The Opthalmology Pacs market report further describes a complete market dynamic such as opportunities, market drivers, as well as challenges prevalent in the global market to better understand the Opthalmology Pacs market more deeply. In addition to this, the Opthalmology Pacs market report also offers qualitative as well as qualitative analysis of very segment along with its revenues and investment details in the market. The Opthalmology Pacs market research report also describes the leading continents as well as their major countries with the profiles of major players operating across the global market.

Browse the complete report @ https://www.adroitmarketresearch.com/industry-reports/opthalmology-pacs-market

Global Opthalmology Pacs market is segmented based by type, application and region.

Based on Type, the market has been segmented into:

By End-Use, market is segmented into:

HospitalsAmbulatory Surgical Center (ASCS) & Specialty ClinicsOthersBy Type, market is segmented into:

Standalone PACSIntegrated PACSBy Delivery Model, market is segmented into:

Cloud/ web based modelsOn-premise modelsOthers

The company profiles also covers the detailed description and segmentation of the companies along the finances which are being covered for the company. The global Opthalmology Pacs market is likely to provide insights for the major strategies which is also estimated to have an impact on the overall growth of the market. Several strategies such as the PESTEL analysis and SWOT analysis is also being covered for the global market. These strategies have an impact on the overall market. Furthermore, several factors such as the emergence of new opportunities is also likely to boost the growth of the market. In addition, the market research provides several detailed analysis for the market which has an impact for the end user.

The Opthalmology Pacs market report also comprises business augmentation projects, retailers, consumers, the Opthalmology Pacs market deals network, suppliers, data sources, research findings, as well as reference section. The market study on the global Opthalmology Pacs market also gives in-depth research regarding the market share, market conditions, and market segmentation. Moreover, this research study focuses on the broad landscape of this market with its progress prospects over the forecast period. Additionally, the research study also encompasses a discussion of the leading players operating in the global Opthalmology Pacs market. Likewise, the study also covers the several major regions such as Europe, Asia Pacific, North America, and MEA.

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Protection under the sun | News | dailyindependent.com – The Independent

July 9th, 2020 8:48 pm

Sunlight is essentially radiation from the sun that makes its way to earth. This radiation, commonly referred to as sunlight, is what lights and warms the earth and facilitates life all across the planet.

Even at night, the light we call moonlight is simply a reflection of the radiant energy emanating from the sun. But sunlight is far more than the rays we perceive as light with our eyes. Beyond what our eyes can register, other rays such as ultraviolet rays, are also a part of what the sun sends our way.

Ultraviolet radiation is a form of non-ionizing radiation that comes from sunlight and various artificial sources such as tanning beds, the mercury vapor lighting often found in high school gymnasiums, as well as halogen, fluorescent and incandescent lights. Different types of ultraviolet radiation can also be generated by welding machines and other sources. In short, ultraviolet radiation is in most environments where human beings might find themselves. And just like light, ultraviolet radiation also reflects of off surfaces such as water, glass, and even snow.

Among the many things which ultraviolet rays contribute to or cause are the premature aging and loss of elasticity in skin and skin cancer. These are possible regardless of skin type or color, and though many might believe darker skin is a protection from ultraviolet rays, any protection it affords is minimal. The conventional wisdom that a good suntan protects us from the harmful effects of sunlight isnt as accurate as you might think. It merely shows less, and the damage is not as readily apparent on tanned or darker skin as it may be on untanned or fairer skin tones.

The damage caused is typically slower in becoming obvious; even a serious sunburn will fade or peel and be replaced by new skin. And the effects do not stop at skin, either. Serious and/or continuous exposure to harmful ultraviolet rays is listed as a causative factor in many eye conditions and diseases. Macular degeneration, inflamed corneas, pterygium and cataracts are caused or made worse by UV exposure.

Ultraviolet rays can put you at increased risk for cataracts and macular degeneration, said Stephanie Sizemore, a triage technician at Ashland Opthalmology. Sizemore said this is especially true if you happen to have a fair complexion or if youre outside for an extended period of time each day. When you are outside, especially for long periods of time, you need to be wearing sunglass with at least a 400 UV rating. And if you work outside, you definitely need to be wearing them.

Sizemore said that artificial sources of ultraviolet radiation are equally as dangerous as the rays found in sunlight, and can be more dangerous when concentrated.

I know Dr. Daniels here does not recommend any sort of tanning beds, Sizemore said. The concentration of ultraviolet light is unhealthy for both the skin and the eyes, and it is difficult to completely protect the eyes under tanning bed conditions. Most people are not going to be exposed to arc or other types of welding machines, but she stressed the importance of the proper eye protection for those individuals who are required to use them.

The difference is you notice damage from machines right away, Sizemore said. Welders talk about getting flash-burned and you notice that almost immediately.

There are also related issues which can be complicated due to overexposure and sometimes occasional exposure to ultraviolet rays, Sizemore said. When you are dealing with diabetes, for instance, one of the things you have to worry about is diabetic retinopathy, which is basically leaky blood vessels at the back of the eye. And overexposure can affect that as well. Reflected UV rays are pretty much just as bad as direct exposure, so you need to be careful to wear eye protection any time you are around reflected ultraviolet rays.

Nearly every health professional today will recommend that individuals limited extended (unprotected) exposure to the sun whether considering skin or eyes. Use sunscreen and 400-plus rated protection sunglasses, and use a wide-brimmed hat when not able to limit the exposure. This doesnt mean that we cant get out and have a good time in the sun; it is just that most health professionals recommend limited over extended exposure, and regular eye exams and doctors visits.

We are making critical coverage of the coronavirus available for free. Please consider subscribing so we can continue to bring you the latest news and information on this developing story.

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Corneal Perforations Can Now Be Fixed Permanently Without the Need for a Transplant According to University of Montreal Researchers – Gilmore Health…

July 9th, 2020 8:48 pm

The cornea is the clear anterior portion of the eye that surrounds the pupil and iris. It is crucial for the eyes focusing power as it refracts light and is responsible for most of the eyes optical power. Damage or destruction of the corneal layer can cause permanent visual impairment. In various conditions such as bullous keratopathy, corneal dystrophy, keratoconus, keratitis, corneal ulcer, and trauma, corneal damage may be beyond conservative repair.

Read Also: UC Berkeley Researchers Restore Vision in Mice Through Gene Insertion

In such situations, corneal transplantation is currently the only method for restoring vision. However, with a limited number of donors, most of the visually impaired do not get an opportunity to become a recipient of a corneal transplant. A cornea can only be obtained from a recently deceased person within 24 hours explaining its limited supply.

Read Also: An Artificial Retina to Restore Sight Could Soon Become a Reality

However, this issue may soon be resolved owing to a revolutionary breakthrough in Opthalmology which may provide a viable alternative to corneal transplantation. Researchers from Europe, North America, and Oceania have collaborated together to achieve this new approach to corneal replacement.

The team led by May Griffith from the Maisonneuve-Rosemont Hospital Research Center, which is affiliated with the University Of Montreal published the results of their findings in the journal Science Advances.

Read Also:Age-related Close-up Vision Loss- How do I rid myself of reading glasses?

Up until now, Corneal perforations could only be completely treated via transplantation. Patients with corneal perforations have to be on a long waiting list for corneal donors due to a global shortage. Until a donor becomes available, their corneas are closed off with a medical-grade glue which is only a temporary solution and not tolerated well by the eyes. Their work has led to an effective and accessible solution called LiQD Cornea to treat corneal perforations without the need for transplantation.

LIQD Cornea is a biocompatible synthetic adhesive liquid hydrogel that can be applied as a liquid glue that can rapidly adhere to the corneal tissue sealing the perforation.

This is good news for the many patients who are unable to undergo this operation due to a severe worldwide shortage of donor corneas, said Griffith, a professor in the Department of Ophthalmology at University of Montreal.

Read Also:Age-related CA $15 Red Light Flashlight Could Help Improve Vision in Those Over 40lose-up Vision Loss- How do I rid myself of reading glasses?

This potentially life-altering treatment could help patients with corneal perforations avoid permanent vision loss.

Vision is the sense that allows us to appreciate how the world around us looks, said Griffith. Allowing patients to retain this precious asset is what motivates our actions as researchers every day of the week.

References:

LiQD Cornea: Pro-regeneration collagen mimetics as patches and alternatives to corneal transplantation

WHO Warning! Too Much Time Staring at a Screen Can Make You Nearsighted

Researchers Explain How Opsin 3 Is Related to Pigmentation Disorders

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How COVID-19 Impact and affected the Global Connective Tissue Growth Factor Market:Demand, Share, Size, Industry Trends, Analysis and Forecast during…

July 9th, 2020 8:48 pm

A latest research report published by ReportsPedia provides a complete market analysis comprising of market size, share, value, growth, and trends for the period 2020-2025. The study also offers a brief summary of market valuation, market size, the regional outlook of the industry. Furthermore, the report inspects the competitive sphere and enlargement strategies of leading players in the Connective Tissue Growth Factor market.

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Leading Connective Tissue Growth Factor Market Players:

BLR Bio LLCFibroGen IncProMetic Life Sciences IncRXi Pharmaceuticals Corp

The research report offers a complete assessment of the market and includes thoughtful insights, facts, historical data, and statistically supported and industry-proven market data. It also includes predictions using appropriate assumptions and methodologies. The report analyzes the business on different parameters consisting of raw materials, cost, technology, and consumer preference.

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The Connective Tissue Growth Factor market is segmented as North America, South America, Europe, Asia Pacific, and the Middle East and Africa. Researchers have thoroughly studied the historical market. With extensive research, experts have offered details on the current and the forecast demand made by these regions. Connective Tissue Growth Factor market research report further offers information on the unexplored areas in these regions to help the producers to plan promotional strategies and create demand for their new and updated products. This will again help the manufacturers to increase their customers and emerge as leaders in the near future.

Global Connective Tissue Growth Factor Market Split by Product Type and Applications:

This report segments the global Connective Tissue Growth Factor Market based on Types are:BLR-200IB-DMDOLX-201PBI-4050Others

Based on Application, the Global Connective Tissue Growth Factor Market is segmented into:

Hypertrophic ScarsOpthalmologyGenetic DisordersLiver FibrosisOthers

Highlights of the Plastic Laser Welding Systems Market Report:

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Key questions answered in the report include:

Table of Content:

Global Connective Tissue Growth Factor Market Research Report

Chapter 1 Connective Tissue Growth Factor Market Overview

Chapter 2 Global Economic Impact on Industry

Chapter 3 Global Market Competition by Manufacturers

Chapter 4 Global Connective Tissue Growth Factor Market Production, Revenue (Value) by Region

Chapter 5 Global Supply (Production), Consumption, Export, Import by Regions

Chapter 6 Global Connective Tissue Growth Factor market Production, Revenue (Value), Price Trend by Type, Application

Chapter 7 Global Connective Tissue Growth Factor Market Effect, Factors, Analysis

Chapter 8 Marketing Strategy Analysis, Distributors/Traders

Continue For Toc.

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Global Industrial Refrigeration Systems Market Covering Developing Trends, Major Highlights With Global Analysis and Forecast By 2027 – Market…

July 9th, 2020 8:48 pm

ReportsPedia has newly added this expansive helpful data of the market, titled Industrial Refrigeration Systems Market. This statistical surveying research report deals with the current scenario of the global market. It has been accumulate to inclusive a couple of research methodologies such as primary and secondary research. The Industrial Refrigeration Systems Market data has been experiential to comprehensive industry-specific analysis tools like SWOT and Porters five techniques. Furthermore, the study also provides deliverables pertaining to the regulatory and competitive landscapes and the strategic perspectives of various industry contenders with respect to the Industrial Refrigeration Systems Industry.

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Top key Players:

Johnson Controls, Inc.Ingersoll-Rand PLCLU-VE S.P.A.United Technologies CorporationThe Danfoss GroupMayekawa Mfg. Co. Ltd.Baltimore Aircoil CompanyGEA Group AGDaikin Industries, Ltd.Bitzer Kuhlmaschinenbau GmbHLennox International Inc.Evapco, Inc.Emerson Electric Co.

For all-inclusive understanding of market dynamics, the global Industrial Refrigeration Systems Market is analyzed across key geographies namely: United States, United Kingdom, France, Italy, Spain, Germany, Japan, China, India and Brazil.

COVID-19 virus outbreak in December 2019, The disease has increased to almost 100 countries around the globe. COVID-19 can influence the worldwide economy in three main behaviour: by directly affecting production and demand, by creating supply chain and market disruption, and by its financial impact on firms and financial markets.

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Global Industrial Refrigeration Systems Market Split By Product Type And Applications :

The report segments the Global Industrial Refrigeration Systems Market on the basis of Types as follows:

CompressorsCondensersEvaporators

On the basis of Application, the Global Industrial Refrigeration Systems Market is segmented into:

Food and BeveragesPharmaceuticalsPetrochemicals

Major highlights of the report:

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In This Study, The Years Considered to estimation the Size of Global Industrial Refrigeration Systems Market are as follows:

Table of Contents:

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COVID-19 Impact: Absorbable and Non-Absorbable Sutures Market | Strategic Industry Evolutionary Analysis Focus on Leading Key Players and Revenue…

July 9th, 2020 8:48 pm

Absorbable and Non-Absorbable Sutures Market report is to provide accurate and strategic analysis of the Profile Projectors industry. The report closely examines each segment and its sub-segment futures before looking at the 360-degree view of the market mentioned above. Market forecasts will provide deep insight into industry parameters by accessing growth, consumption, upcoming market trends and various price fluctuations.

This has brought along several changes in This report also covers the impact of COVID-19 on the global market.

Absorbable and Non-Absorbable Sutures Market competition by top manufacturers as follow: , B. Braun Melsungen AG, Ethicon, Smith & Nephew, Demetech Corporation, Conmed Corporation, W.L. Gore & Associates, Tepha, Meta Biomed, Zimmer Biomet, CP Medical, Miltex (A Integra LifeSciences Corporation Company), Assut Medical Sarl, DyNek Pty, Footberg, Stoelting, Unimed Medical Industries, Teleflex Incorporated, Boston Scientific Corporation, Medtronic, Surgical Specialties Corporation, Resorba Medical GmbH, Medline Industries, AD Surgical, Santec Medicalprodukte, Clinisut, Coreflon, Aspen Surgical, Medipac, Sutures, Pierson Surgical

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Global Absorbable and Non-Absorbable Sutures Market research reports growth rates and market value based on market dynamics, growth factors. Complete knowledge is based on the latest innovations in the industry, opportunities and trends. In addition to SWOT analysis by key suppliers, the report contains a comprehensive market analysis and major players landscape.The Type Coverage in the Market are: Absorbable SuturesNon-Absorbable Sutures

Market Segment by Applications, covers:CardiovascularOrthopedicGynecologyOpthalmologyGeneral SurgeryOthers

Market segment by Regions/Countries, this report coversNorth AmericaEuropeChinaRest of Asia PacificCentral & South AmericaMiddle East & Africa

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Dried Laver Market ? Key Players, Size, Trends, Growth Opportunities, Analysis and Forecast To 2025 – Market Research Publicist

July 9th, 2020 8:48 pm

A new research study has been presented by UpMarketResearch.com offering a comprehensive analysis on the Global Dried Laver Market where user can benefit from the complete market research report with all the required useful information about this market. This is a latest report, covering the current COVID-19 impact on the market. The pandemic of Coronavirus (COVID-19) has affected every aspect of life globally. This has brought along several changes in market conditions. The rapidly changing market scenario and initial and future assessment of the impact is covered in the report. The report discusses all major market aspects with expert opinion on current market status along with historic data. This market report is a detailed study on the growth, investment opportunities, market statistics, growing competition analysis, major key players, industry facts, important figures, sales, prices, revenues, gross margins, market shares, business strategies, top regions, demand, and developments.

The Dried Laver Market report provides a detailed analysis of the global market size, regional and country-level market size, segment growth, market share, competitive landscape, sales analysis, impact of domestic and global market players, value chain optimization, trade regulations, recent developments, opportunity analysis, strategic market growth analysis, product launches, and technological innovations.

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Major Players Covered in this Report are: SeakuraKelpakSeagate ProductsCargillIrish SeaweedsAlgAranDakini Tidal WildsWild Irish Sea Veg

Global Dried Laver Market SegmentationThis market has been divided into Types, Applications, and Regions. The growth of each segment provides an accurate calculation and forecast of sales by Types and Applications, in terms of volume and value for the period between 2020 and 2026. This analysis can help you expand your business by targeting qualified niche markets. Market share data is available on the global and regional level. Regions covered in the report are North America, Europe, Asia Pacific, the Middle East & Africa, and Latin America. Research analysts understand the competitive strengths and provide competitive analysis for each competitor separately.

By Types:Type IType II

By Applications:SupermarketsFood StoresOnline Retailers

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Global Dried Laver Market Regions and Countries Level AnalysisRegional analysis is a highly comprehensive part of this report. This segmentation sheds light on the sales of the Dried Laver on regional- and country-level. This data provides a detailed and accurate country-wise volume analysis and region-wise market size analysis of the global market.

The report offers an in-depth assessment of the growth and other aspects of the market in key countries including the US, Canada, Mexico, Germany, France, the UK, Russia, Italy, China, Japan, South Korea, India, Australia, Brazil, and Saudi Arabia. The competitive landscape chapter of the global market report provides key information about market players such as company overview, total revenue (financials), market potential, global presence, Dried Laver sales and revenue generated, market share, prices, production sites and facilities, products offered, and strategies adopted. This study provides Dried Laver sales, revenue, and market share for each player covered in this report for a period between 2016 and 2020.

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Table of Contents1. Executive Summary2. Assumptions and Acronyms Used3. Research Methodology4. Market Overview5. Global Market Analysis and Forecast, by Types6. Global Market Analysis and Forecast, by Applications7. Global Market Analysis and Forecast, by Regions8. North America Market Analysis and Forecast9. Latin America Market Analysis and Forecast10. Europe Market Analysis and Forecast11. Asia Pacific Market Analysis and Forecast12. Middle East & Africa Market Analysis and Forecast13. Competition Landscape

About UpMarketResearch:Up Market Research (https://www.upmarketresearch.com) is a leading distributor of market research report with more than 800+ global clients. As a market research company, we take pride in equipping our clients with insights and data that holds the power to truly make a difference to their business. Our mission is singular and well-defined we want to help our clients envisage their business environment so that they are able to make informed, strategic and therefore successful decisions for themselves.

Contact Info UpMarketResearchName Alex MathewsEmail [emailprotected]Organization UpMarketResearchAddress 500 East E Street, Ontario, CA 91764, United States.

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Infection Control in Cancer Therapy Market (impact of COVID-19) Growth, Overview with Detailed Analysis 2020-2026| Kimberly Clark Corporation, 3M…

July 9th, 2020 8:45 pm

COVID-19 Impact on GlobalInfection Control in Cancer TherapyMarket Size, Status and Forecast 2020-2026

This report studies theInfection Control in Cancer Therapy marketwith many aspects of the industry like the market size, market status, market trends and forecast, the report also provides brief information of the competitors and the specific growth opportunities with key market drivers. Find the completeInfection Control in Cancer Therapy marketanalysis segmented by companies, region, type and applications in the report.

New vendors in the market are facing tough competition from established international vendors as they struggle with technological innovations, reliability and quality issues. The report will answer questions about the current market developments and the scope of competition, opportunity cost and more.

The major players covered in Infection Control in Cancer Therapy Market:Kimberly Clark Corporation, 3M Healthcare Company, Honeywell International, Inc., Getinge Group AB, Sterigenics International, Sakura Global Holding Company, Arizant Healthcare Inc., Nordion, Cisa S.P.A., Steris Corporation, Nordion, Inc., Ahlstrom Filtration LLC, Membrana GmbH, Synergy Health, Plc, Advanced Sterilization Products Services, Inc

The final report will add the analysis of the Impact of Covid-19 in this report Infection Control in Cancer Therapy industry.

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Infection Control in Cancer TherapyMarket in its database, which provides an expert and in-depth analysis of key business trends and future market development prospects, key drivers and restraints, profiles of major market players, segmentation and forecasting. An Infection Control in Cancer Therapy Market provides an extensive view of size; trends and shape have been developed in this report to identify factors that will exhibit a significant impact in boosting the sales of Infection Control in Cancer Therapy Market in the near future.

This report focuses on the globalInfection Control in Cancer Therapystatus, future forecast, growth opportunity, key market and key players. The study objectives are to present the Infection Control in Cancer Therapy development inUnited States, Europe, China, Japan, Southeast Asia, India, and Central & South America.

Market segment by Type, the product can be split into

Market segment by Application, split into

TheInfection Control in Cancer Therapymarket is a comprehensive report which offers a meticulous overview of the market share, size, trends, demand, product analysis, application analysis, regional outlook, competitive strategies, forecasts, and strategies impacting the Infection Control in Cancer Therapy Industry. The report includes a detailed analysis of the market competitive landscape, with the help of detailed business profiles, SWOT analysis, project feasibility analysis, and several other details about the key companies operating in the market.

The study objectives of this report are:

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TheInfection Control in Cancer Therapymarket research report completely covers the vital statistics of the capacity, production, value, cost/profit, supply/demand import/export, further divided by company and country, and by application/type for best possible updated data representation in the figures, tables, pie chart, and graphs. These data representations provide predictive data regarding the future estimations for convincing market growth. The detailed and comprehensive knowledge about our publishers makes us out of the box in case of market analysis.

Key questions answered in this report

Table of Contents

Chapter 1:GlobalInfection Control in Cancer TherapyMarket Overview

Chapter 2:Infection Control in Cancer Therapy Market Data Analysis

Chapter 3:Infection Control in Cancer Therapy Technical Data Analysis

Chapter 4:Infection Control in Cancer Therapy Government Policy and News

Chapter 5:Global Infection Control in Cancer Therapy Market Manufacturing Process and Cost Structure

Chapter 6:Infection Control in Cancer Therapy Productions Supply Sales Demand Market Status and Forecast

Chapter 7:Infection Control in Cancer Therapy Key Manufacturers

Chapter 8:Up and Down Stream Industry Analysis

Chapter 9:Marketing Strategy -Infection Control in Cancer Therapy Analysis

Chapter 10:Infection Control in Cancer Therapy Development Trend Analysis

Chapter 11:Global Infection Control in Cancer Therapy Market New Project Investment Feasibility Analysis

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Reports and Marketsis not just another company in this domain but is a part of a veteran group calledAlgoro Research Consultants Pvt. Ltd. It offers premium progressive statistical surveying, market research reports, analysis & forecast data for a wide range of sectors both for the government and private agencies all across the world. The database of the company is updated on a daily basis. Our database contains a variety of industry verticals that include: Food Beverage, Automotive, Chemicals and Energy, IT & Telecom, Consumer, Healthcare, and many more. Each and every report goes through the appropriate research methodology, Checked from the professionals and analysts.

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3 Healthy Habits That Can Help You Live Longer – News18

July 9th, 2020 7:48 pm

For a long time now, humans have been looking for the secret to a long and healthy life. Some say it's all about genetics and some associate it with better availability of healthcare facilities. Sure, it is possible for some to be genetically gifted to have a longer life. But genes dont play as huge a role in longevity as your environment and lifestyle.

Studies have shown that people who live more than 100 years have various things in common, the top amongst them being their healthy lifestyle and their positive outlook towards life.

Here are 3 secrets to living a healthy and long life from centenarians (those who have lived beyond 100 years):

1. A healthy diet

A healthy and balanced diet is undoubtedly one of the keys to good health. Experts suggest that a balanced diet should have 7 components - carbs, proteins, unsaturated fats, fibre, vitamins, minerals and water. Water plays a role in various metabolic activities in the body. Make sure you drink at least 8-10 glasses of water a day.

Avoid overeating at all costs since it would promote obesity, which may further increase your risk of various chronic diseases. Instead, follow caloric restriction whenever possible. Caloric restriction is an excellent way to promote longevity. Various studies show the benefits of caloric restriction on health, including one done in Japan that showed how lifetime caloric restriction reduces the risk of diseases and increases lifespan. It can also help you reduce weight.

It is important to note that the term overeating may not mean the same for everyone. Overeating means eating more calories than you need in a day. Daily calorie requirement for different people varies as per their age, sex and physical activity levels. Long term caloric restriction may cause a constant feeling of hunger and low body temperature. So, it is best to talk to a dietician if you are thinking of trying it.

2. Workout regularly

Regular physical activity keeps up your muscle strength, improves your immune system and reduces your risk of chronic diseases including diabetes, heart diseases and cancer. It also improves memory and cognition and can reduce depression and elevate mood.

Experts suggest doing at least 30 minutes of moderate to vigorous activity daily to keep up your health.

However, like every good thing, over-exercising may do more harm than good, especially if you have a health condition. Also, if you dont generally work out, dont jump into the deep end and instead start slowly with a 5-10 minute routine first. Increase the duration and intensity gradually.

3. Be positive

A positive outlook can do miracles for both your mental and physical health. It reduces depression and the risk of diseases. A 35-year-long study done in the USA showed a direct connection between optimism and mortality rate.

On the other hand, stress and anxiety can trigger various pathological conditions. Try and practice mindfulness, breathing exercises and meditation to help reduce stress. Dont hesitate to reach out to your friends and family if you need help

For more information, read our article onBalanced diet chart.

Health articles on News18 are written by myUpchar.com, Indias first and biggest resource for verified medical information. At myUpchar, researchers and journalists work with doctors to bring you information on all things health.

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The information provided here is intended to provide free education about certain medical conditions and certain possible treatment. It is not a substitute for examination, diagnosis, treatment, and medical care provided by a licensed and qualified health professional. If you believe you, your child or someone you know suffers from the conditions described herein, please see your health care provider immediately. Do not attempt to treat yourself, your child, or anyone else without proper medical supervision. You acknowledge and agree that neither myUpchar nor News18 is liable for any loss or damage which may be incurred by you as a result of the information provided here, or as a result of any reliance placed by you on the completeness, accuracy or existence of any information provided herein.

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Inherited Metabolic Disorders (IMD) Market Promising Growth Opportunities and Forecast 2017-2025 – Daily Research Chronicles

July 9th, 2020 7:48 pm

Global Inherited Metabolic Disorders (IMD) Market: Snapshot

Inherited metabolic disorders (IMD), as the name suggests, are genetic conditions resulting in metabolism issues. The root cause behind maximum cases of inherited metabolic disorders (IMD) is a gene mutation that probably happened a lot many generations back. The mutation in the gene is carried through the generations.

Treatment of inherited metabolic disorders (IMD) consists of dietary supplementation, dietary restrictions, drugs that thwart or regulate metabolism, gene therapy, transplantation of the concerned organ, and dialysis in extreme cases. Currently, the dietary supplements account for a leading position in the global inherited metabolic disorders (IMD) treatment market. Drug manufacturers, however, are slated to come up with more condition-specific therapeutics in the near future.

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The specificity and high risk affinity of IMD differs from disorder to disorder. Some disorders such as familial cylomicronemia are generally associated closely with Caucasians, while others, namely porphyria is mostly recorded among African Americans. Most of such metabolic disorders are be brought under control with certain changes in the diet and lifestyle of the person. Some inherited metabolic disorders (IMDs) are, however, life threatening. Huntingtons or Zellweger syndrome is to name one such.

The inherited metabolic disorders market lies mostly with the Caucasian and African American populations of world, especially in North America, Europe, Australia, and Africa, followed by the minority populations from South Asia and East A.

At present, genetic screening using mass spectrometry and DNA testing among all newborns are carried out in almost all of the developed nations of the world and also in developing economies of India, Brazil, and China. This helps uncover inherited metabolic disorders (IMD) at an early stage.

GlobalInherited Metabolic Disorders Market: Overview

Globally, IMD affects nearly one in every 2,500 to 5,000 individuals with nearly 300 to 600 new cases found in the U.K., according to Public Health Genetics U.K. The specificity and high risk affinity of IMD varies from disorder to disorder, with some disorders like familial cylomicronemia being closely associated with Caucasians and others like porphyria being recoded largely among African Americans. These metabolic disorders are often controllable with certain lifestyle and diet changes, including Familial Cylomicronemia and Phenylketonuria. But some IMDs are highly dangerous and may affect the survivability of a person, such as Huntingtons or Zellweger syndrome.

A lot of IMDs arise when the mutated gene responsible is inherited by the natural selection process and a large number of these genes are recessive. This is probably why a large number of these metabolic disorders are rare occurrences, whereas certain other genes are dominant in nature; this makes it difficult for a willing parent to conceive a child as the risk for transferring a gene remains high (e.g. Huntingtons). Familial chylomicronemia occurs when an individual genetically inherits Lipoprotein lipase enzyme mutation. This is a very rare genetic disease at occurrence rate of 1 individual per million with chances of symptoms occurring only in homozygous individuals (receiving mutation genes from both parents) or in other words recessive gene transmission.

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GlobalInherited Metabolic Disorders Market: Current Market Trends

Nowadays, genetic screening via mass spectrometry and DNA testing of all newborn children are done in nearly all of the developed countries and also some developing countries of the world, including India, China, and Brazil, albeit across a small percentage of the national population. This prepares a parent and the child with the necessary precautions and treatment for increasing the longevity of the concerned newborn. The life expectancy of such a child with all the necessary care and precaution is at par with the average individual.

However among many adult populations and in some children, rare genetic metabolic disorders are abruptly presented and often not accurately diagnosed. In such individuals, abnormal metabolic changes are considered to be a type of genetic mutation in routine diagnosis. Symptoms such as growth failure, precocious puberty and development delay in children below 12, and anemia, neurological disorder, cancer, muscle weakness, rapid hormonal changes, and skin changes in adults, are regarded to probably have a genetic metabolic cause.

GlobalInherited Metabolic Disorders Market: Treatment Classifications

The treatment of IMDs is broadly classified into dietary restrictions, dietary supplementation, drugs that inhibit or regulate metabolism, transplantation of the concerned organ, gene therapy, and dialysis in severe cases. In the case of familial cylomicronemia, gene therapy includes Alipogene tiparvovec recombinant gene therapy drug, manufactured by UniQure Inc. This therapy utilizes viruses (adenovirus vector) designed in such a way that upon infection, the gene for producing the lipoprotein lipase is induced into the host cell, thereby producing the enzyme in-vivo. This therapy has shown positive results and is expected to be released into the market soon. For now, the global inherited metabolic disorders Market lies broadly in the dietary supplements market.

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Brain Benefits of Exercise Can Be Gained with a Single Protein – UCSF News Services

July 9th, 2020 7:47 pm

A little-studied liver protein may be responsible for the well-known benefits of exercise on the aging brain, according to a new study in mice by scientists in the UC San Francisco Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research.

The findings could lead to new therapies to confer the neuroprotective effects of physical activity on people who are unable to exercise due to physical limitations.

Exercise is one of the best-studied and most powerful ways of protecting the brain from age-related cognitive decline and has been shown to improve cognition in individuals at risk of neurodegenerative disease such as Alzheimers disease and frontotemporal dementia even those with rare gene variants that inevitably lead to dementia.

But many older adults are not able to exercise regularly due to physical limitations or disabilities, and researchers have long searched for therapies that could confer some of the same neurological benefits in people with low physical activity levels.

The new study, published July 9, 2020, in Science, showed that after mice exercise, their livers secrete a protein called Gpld1 into the blood. Levels of this protein in the blood correspond to improved cognitive function in aged mice, and a collaboration with the UCSF Memory and Aging Center found that the enzyme is also elevated in the blood of elderly humans who exercise regularly. But the researchers showed that simply increasing the amount of Gpld1 produced by the mouse liver could confer many of the same brain benefits as regular exercise.

If there were a drug that produced the same brain benefits as exercise, everyone would be taking it. Now our study suggests that at least some of these benefits might one day be available in pill form, said study senior author Saul Villeda, PhD, a UCSF assistant professor in the departments of Anatomy and of Physical Therapy and Rehabilitation Science.

Villedas lab has previously shown that biological factors present in the blood of young mice can rejuvenate the aging mouse brain, and conversely, factors in the blood of older mice can bring on premature age-related cognitive decline in young mice.

These previous results led Villeda lab graduate student Alana Horowitz and postdoctoral researcher Xuelai Fan, PhD, to pursue blood-borne factors that might also confer the benefits of exercise, which is also known to rejuvenate the aging brain in a similar fashion to what was seen in the labs young blood experiments.

Horowitz and Fan took blood from aged mice who had exercised regularly for seven weeks and administered it to sedentary aged mice. They found that four weeks of this treatment produced dramatic improvements in learning and memory in the older mice, similar to what was seen in the mice who had exercised regularly. When they examined the animals brains, they found evidence of enhanced production of new neurons in the region known as the hippocampus, a well-documented proxy for the rejuvenating benefits of exercise.

To discover what specific biological factors in the blood might be behind these effects, Horowitz, Fan and colleagues measured the amounts of different soluble proteins in the blood of active versus sedentary mice. They identified 30 candidate proteins, 19 of which, to their surprise, were predominantly derived from the liver and many of which had previously been linked to functions in controlling the bodys metabolism. Two of these proteins Gpld1 and Pon1 stood out as particularly important for metabolic processes, and the researchers chose to study Gpld1 in more detail because few previous studies had investigated its function.

We figured that if the protein had already been investigated thoroughly, someone would have stumbled upon this effect, Villeda said. I like to say if youre going to take a risk by exploring something new, you might as well go big!

The team found that Gpld1 increases in the blood circulation of mice following exercise, and that Gpld1 levels correlate closely with improvements in the animals cognitive performance. Analysis of human data collected as part of the UCSF Memory and Aging Centers Hillblom Aging Network study showed that Gpld1 is also elevated in the blood of healthy, active elderly adults compared to less active elders.

If there were a drug that produced the same brain benefits as exercise, everyone would be taking it. Now our study suggests that at least some of these benefits might one day be available in pill form.

Saul Villeda, PhD

To test whether Gpld1 itself could drive the observed benefits of exercise, the researchers used genetic engineering to coax the livers of aged mice to overproduce Gpld1, then measured the animals performance in multiple tests that measure various aspects of cognition and memory. To their amazement, three weeks of the treatment produced effects similar to six weeks of regular exercise, paired with dramatic increases in new neuron growth in the hippocampus.

To be honest, I didnt expect to succeed in finding a single molecule that could account for so much of the benefits of exercise on the brain. It seemed more likely that exercise would exert many small, subtle effects that add up to a large benefit, but which would be hard to isolate. Villeda said. When I saw these data, I was completely floored.

Through this protein, the liver is responding to physical activity and telling the old brain to get young, Villeda added. This is a remarkable example of liver-to-brain communication that, to the best of our knowledge, no one knew existed. It makes me wonder what else we have been missing in neuroscience by largely ignoring the dramatic effects other organs might have on the brain, and vice versa.

Further laboratory experiments have shown that Gpld1 produced by the liver does not pass through the so-called blood-brain barrier, which protects the brain from toxic or infectious agents in the blood. Instead, the protein appears to exert its effects on the brain via pathways that reduce inflammation and blood coagulation throughout the body. Both blood coagulation and inflammation are known to be elevated with age and have been linked to dementia and age-related cognitive decline.

The lab is now working to better understand precisely how Gpld1 interacts with other biochemical signaling systems to produce its brain-boosting effects, in hopes of identifying specific targets for therapeutics that could one day confer many of the protective benefits of exercise for the aging brain.

Authors: Additional authors on the study were Gregor Bieri, Lucas Smith, Cesar Sanchez-Diaz, Adam Schroer, and Geraldine Gontier of the UCSF Department of Anatomy; Kaitlin Casaletto and Joel Kramer of the UCSF Memory and Aging Center; and Katherine E. Williams of the UCSF Sandler-Moore Mass Spectrometry Core Facility.

Funding: The research was funded by Hillblom Foundation predoctoral and postdoctoral fellowships, Irene Diamond AFAR postdoctoral fellowship, the National Institutes of Health (NIH) National Institute on Aging (NIA) (AG064823, AG058752, AG023501, AG053382, AG055797), and a gift from Marc and Lynne Benioff.

Disclosures: The authors declare no conflict of interest. Horowitz, Fan, and Villeda are named as inventors on a patent application arising from this work.

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Brain Benefits of Exercise Can Be Gained with a Single Protein - UCSF News Services

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