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Boost your immunity to sail through the Monsoon

New Delhi, June 22 (IANSlife) This year has been nothing short of eventful so far, and with monsoon knocking at our doors, little modifications in our diet can save us from more unwanted trouble on the health front.

It is a cue for everyone to adopt a diet that suits the changing weather, which brings with it seasonal maladies such as the flu, allergies, and infections.

With the worldwide threat of the coronavirus pandemic looming at large, now is not the time to get sick and be privy to a whole lot of infections. The period calls for building a strong and robust immunity that will help you steer clear of the season''s diseases.

The best way to go about it is practicing a balanced lifestyle which involves nutritious eating habits, plenty of exercise, yoga and meditation, deep sleep and a positive outlook towards life. Eating right is perhaps the most crucial aspect towards a healthy and disease free body, Gaia founder and director Dolly Kumar told IANSlife.

Here is her list of five super-healthy foods that will not only boost your immunity and health but also ensure that you remain active and focused during the day.

Green tea

Every Indian loves a nice cup of steaming hot tea especially during the monsoon hours. Sipping tea in the comfort of your homes while listening to the music of the monsoon shower is one of the simpler pleasures of life. Instead of having the regular milk and sugar concoction, switch to a nice and aromatic cup of green tea. A warm healthy dose of green tea helps you stay invigorated throughout the day. Green tea is fortified with natural antioxidants. It is also a great source for bolstering the immune system and enhancing one''s memory. The minerals and nutrients in green tea help the body to detoxify its impurities accumulated over time. They also improve the body''s digestive system and also help in cleansing the skin.

Honey

It is nature''s answer to most health ailments. Honey is the ideal remedy for sore throats, coughs and cold due to its soothing effect on the throat. Multifloral honey when consumed with some ginger is the perfect cure for ailing throats. A natural substitute for sugar, multifloral honey is also a great immunity booster as it is free from fat, cholesterol and sodium.

Neem

Neem is the king of all medicinal plants and has been used since the ancient times to cure all kinds of diseases and disorders. It is the perfect remedy for stomach bugs, which are so prevalent in this season. The cooling properties of neem are next to none and can be consumed in the form of readymade capsules. Its anti-bacterial, anti-fungal and blood-cleansing properties aid in building up the body''s resistance against external infections and malicious agents. Neem also helps in strengthening the body''s immunity and digestion.

Aloe Vera

Aloe Vera is great for maintaining the overall health. It is a powerhouse of nutrients as it contains more than twenty amino acids and essential minerals such as calcium, magnesium, and sodium along with enzymes, vitamins, polysaccharides, nitrogen and other vital nutrients. It also improves hair and skin texture and keeps them healthy and lustrous. A natural cure for constipation and acidity, Aloe vera can also improve the body''s digestive system.

Olive oil

The rainy season is a catalyst for heightening one''s cravings for fried snacks like pakoras. It is alright to indulge your taste buds every once in a while. Just make sure that you replace the ordinary cooking oil with the healthy and extra flavorful light olive oil. Olive oil being rich in mono-saturated fatty acids, has a light texture that complements a dish perfectly, making it a great alternative to regular cooking oil and ideal for almost all cuisines. It also reduces the risk of cancer, Type-2 Diabetes, cardiovascular diseases and breast cancer as it is packed with numerous anti-oxidants. Now who said fried pakoras cannot be healthy!

(IANSlife can be contacted at ianslife@ians.in)

--IANS

Sj/adr/

Disclaimer :- This story has not been edited by Outlook staff and is auto-generated from news agency feeds. Source: IANS

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Boost your immunity to sail through the Monsoon - Outlook India

The risk of severe COVID-19 infection is more common in those with high blood pressure, diabetes and obesity, conditions that are all associated with changes to the composition of the gut microbiome the community of bacteria, viruses and fungi that live in the intestines. This raises the question of whether the gut microbiome has a role in dictating COVID-19 severity.

Lets recap what we know about COVID-19. COVID-19 is a new disease caused by a very contagious virus called SARS-CoV-2.

In most infected individuals, the virus does not cause serious illness. However, it causes a very serious respiratory disease and even death in a minority of patients. Through many studies of people with COVID-19 over the past few months, we have learned what characteristics are more likely to be linked to mild versus severe forms of the disease.

Children and young adults are less likely to develop symptomatic COVID-19, although infection readily occurs in young people with equally high viral loads in the airway, suggesting that they can certainly infect others. In contrast, people of older age and those with pre-existing chronic conditions are highly at risk and very likely develop symptomatic, severe disease.

If we consider the gradient of severity of the disease, children are at one end, and the elderly and patients with chronic conditions are at the other end.

The information collected by researchers from many countries all points to similar characteristics and health conditions that are more commonly seen in patients with severe disease. These include older age, high blood pressure, diabetes and obesity.

The strength of these associations is even more prominent among younger individuals, as younger patients with obesity and diabetes are more likely to have serious disease.

In New York City, 5,279 patients tested positive for COVID-19 between March 1 and April 8, 2020. Of these, 22.6 per cent had diabetes and 35.3 per cent were obese.

Obesity was associated with an increased rate of hospital admission and critical illness. Similar findings were provided by investigators in the United Kingdom about the outbreak in Britain, where obese patients were twice as likely to develop severe disease.

Do these findings raise the possibility that the mechanisms underlying high blood pressure, diabetes and obesity may help explain why these conditions lead to severe COVID-19 disease? Before exploring this question, lets zoom in on cellular and molecular mechanisms known to be involved in COVID-19 disease.

When the virus enters the body, it mostly goes to the airways and the gastrointestinal tract. The virus then binds to specific receptors present on the surface of epithelial cells to enter these cells. Viral replication within the cells leads to cell damage and cell death. This results in the release of specific signalling molecules that alert the local immune system.

Armies of immune cells are then dispatched to initiate an antiviral response. Some of these cells are specialized to locate and identify the virus, while others mount a specific immune attack. The immune response results in the release of cytokines, chemokines and antibodies, which in many cases can defeat the virus, and the patient recovers.

Sometimes the immune system is dangerously at high alert and overreacts. In this case, the immune cells mount an especially strong inflammatory response one that goes beyond what is required to kill the virus. This extra-strong attack releases cytokines and chemokines on a massive scale throughout the body, resulting in a cytokine storm, which causes widespread inflammation and tissue damage in patients with severe COVID-19.

One of the reasons for an abnormal, overreactive immune response lies in the gastrointestinal tract. Millions of interactions are constantly occurring between the immune system and trillions of non-dangerous microbes that live within the body. These interactions educate the immune system in how to function and, importantly, in how not to overreact to infectious microbes. Could this help explain why some people are more likely to develop uncontrolled inflammation upon COVID-19 infection?

The gut microbiome is the community of micro-organisms living inside the gastrointestinal tract, mostly in the large bowel. The microbiome contains bacteria, fungi (yeast), viruses and protozoa, all of which contribute to maintaining a balanced ecosystem and human health. These microbes collectively perform many beneficial functions, including educating the immune system.

When studying the microbiome, scientists examine the composition (what is there) and function (what are they doing) of this ecosystem. We have learned that both composition and function of the gut microbiome are important features linked to human health. In certain conditions, the balance of the gut microbiome composition and function is disrupted in a way that leads to disease, a phenomenon called microbiome dysbiosis.

There is accumulating evidence from animal and human studies that gut microbiome dysbiosis has a causal role in metabolism dysregulation manifested as diabetes and obesity the risk factors of severe COVID-19 disease.

The gut microbiome regulates host defences against viral infections including respiratory viruses, such as influenza virus. This occurs through the activation of immune antiviral mechanisms and the prevention of excessive inflammation.

Different species of the gut microbiome have pro- or anti-inflammatory properties and play different roles in regulating the immune system. In the context of COVID-19, a recent preprint study (not yet peer reviewed) showed that specific members of the gut microbiome were associated with severe disease and with immune markers known to be elevated in severe disease. The association of these gut bacteria with the immune markers was even higher than that of the known risk factors of COVID-19 severity: age and obesity.

Further work is needed to confirm that pro-inflammatory microbial species can contribute to the immune responses that make severe COVID-19 more likely, but based on what we know about the microbiome, this is certainly a possibility. This also could mean that beneficial gut microbiome species, the type that promote low inflammation, have the potential to prevent or remediate the immune alterations that lead to severe COVID-19.

The research community is working very hard to develop and test safe and effective vaccines and treatments against COVID-19. Tapping into the potential of the gut microbiome is another avenue that we can pursue to identify potential safe and affordable probiotics for prevention and treatment. This is not unprecedented in the context of viral respiratory diseases: probiotics and prebiotics can affect the immune response to the flu vaccine, and may improve outcomes in flu-like illnesses.

Until effective treatments are available, mind your microbes and maintain a healthy lifestyle.

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Gut reaction: How the gut microbiome may influence the severity of COVID-19 - The Conversation CA

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It is better to be a coronavirus patient in June than it was in March.

Back then, there was just so little we knew about the virus: after all, it was a brand new thing. But as scientists and doctors battle this disease that has infected millions and killed more than 460,000 people around the globe, they have learned a good deal about how it attacks the body, and a little more about how to treat it. That means a better chance of survival for those who have the disease.

Unfortunately, this is relevant for an ever-increasing number of Utahns, with more people getting the virus and more people hospitalized than ever before. With that in mind, I thought Id walk you through what we know about the coronavirus right now, as jargon free as possible.

What happens when you inhale the coronavirus, anyway?

Naturally, the virus finds itself in your lungs. Once there, the virus bumps around the inner walls until it finds a cell it can connect to it turns out the spiky exterior on coronaviruses is really well suited to connecting to lung cells called alveolar cells, which are the ones that bring oxygen to your blood. The average person has about 480 million alveoli per lung, so theres plenty of opportunity for infection.

The virus injects its genetic code into the cell, hijacking it and turning it into a copy machine. That produces more of the virus, which can infect your own cells and be exhaled to infect others. As more and more cells become infected, they dont work at their original jobs.

Your immune system, understandably, is not thrilled about this. While it takes a little while for it to notice youve been infected and do something about it anywhere from 2-14 days, with an average of 4-5 days it does eventually mount a response that causes many of the coronavirus symptoms, such as fever or cough. That immune response also typically works to cure people: it kills the infected copy machine cells, your body naturally creates new working ones in their place, and you recover.

Normally, the immune system is pretty good about starting up and shutting down at the right times using an in-body signaling system made up of cytokines. Cytokines promote all sorts of useful immune system functions, but one is that they send more repairing blood to infected sites. They even make blood vessels more permeable than usual so immune system cells can more efficiently get from the blood to attack the infected cells.

However, sometimes the immune system gets overexuberant, as one medical education site put it. Its not always clear why, but in certain cases very bad infections, burns, or other trauma the immune system ends up producing and sending way too many cytokines. This is called a cytokine storm.

The cytokine storm in COVID-19 cases cause big problems. For one, theres now way too much blood going to these infected sites, and they get super inflamed. All of the fluid and blood everywhere means that even the uninfected alveolar cells in your lungs are drowned, and cant work to bring oxygen in your body anymore. That causes Acute Respiratory Distress Syndrome (ARDS).

And those previously-helpful permeable blood vessels now become too permeable: they spring leaks. That means the blood clot system has to start working to fix those leaks, but that creates little blood clots all around your body.

At least the majority of people who die or experience severe symptoms due to COVID-19 end up facing ARDS, either due to the initial viral cell killing or the cytokine storm. But others die from or also experience the results of those blood clots, with problems like heart or kidney failure, even strokes. Thats one reason we kept seeing all of these COVID-19 patients with unexpected symptoms: once your circulatory system stops working well, all sorts of weird stuff can happen.

A team of Harvard researchers proposed a three stage categorization system for coronavirus patients. Stage 1 is mild coronavirus, caused mostly by the negative effects of the virus itself. But the biggest problems come in Stage 3, when the immune system is essentially attacking the body.

What does this mean for treating the virus?

It means that we have to use different treatments at different stages.

Essentially, at the beginning, we want to help the immune system as much as possible. When its working normally, its terrific; so terrific that the majority of people face only mild symptoms. We also want to prevent the virus from making copy machines of itself using antiviral drugs.

However, once were in the moderate or severe stages, we want to suppress the immune system to stop the cytokine storm. We dont want to completely kill the immune system, but reducing its response significantly would lessen many of the most dangerous symptoms. In conjunction, wed also like to prevent or mitigate the effects of those micro blood clots.

It is a tricky balance. In one stage, we want to help the immune system, and in later stages, we want to suppress it. And diagnosing whether a cytokine storm is about to occur or is currently underway isnt necessarily an immediate process: there are lab tests to perform.

Still, this split approach looks like our best chance of treating COVID-19 patients.

What treatments are there for the early stages of the disease?

Remdesivir is the most well-tested antiviral product we have to use against COVID-19. It works by inhibiting virus production in those infected, copy machine cells, and in a randomized, controlled trial, it made a statistically significant but relatively small impact on the amount of time people spent in the hospital with the virus: 11 days on average instead of 14.

It just doesnt make sense to give to everyone with mild symptoms: remdesivir has to be delivered intravenously, which means it probably has to be done in a hospital. Theres also not that much of it to go around.

Ideally, wed find a more easily delivered and effective antiviral product. Were still looking.

Hydroxychloroquine is the option thats gotten the most attention, in part for political reasons. The thinking here is that it works to help prevent malaria infections, so it might work with the coronavirus. By one count, 158 studies that tried to find out whether hydroxychloroquine works or not, in all sorts of combinations. Most of them have been poorly designed, or too small to be elucidating, or based on data so flawed they had to be retracted.

Based on a majority of the studies, the most likely scenario is that it doesnt work against this virus. There are those who will say that it needs to be tested with azithromycin and/or zinc, or only in pre-symptomatic patients, or only on Thursdays. But the scientific community is moving away from this one. The FDA recently pulled its emergency approval to use the drug to treat COVID-19 and the World Health Organization dropped the drug from its huge study into coronavirus treatments.

Another promising path is the use of antibodies. This study from the University of Washington looked at how injecting someone with blood plasma from recovered COVID-19 patients which contains antibodies specific to the coronavirus actually prevented the virus from infecting cells in the first place. We also know that injecting plasma into hospitalized people seems to make a big difference, unless we inject it too late, in which case it probably doesnt work. In short, the antibodies help with the virus but not with the cytokine storm.

The traditional problem with the plasma antibody strategy is that you need the blood of someone who already had the disease but recently recovered, and there arent that many doses of it to go around. Furthermore, those doses tend to vary wildly in terms of effectiveness, because different people produce different numbers and types of antibodies. Finally, the antibodies dont last forever, probably only a month or two.

But if we create those antibodies in a lab, we should be able to make enough doses to give to people who need protection. You can imagine those antibody injections being the bridge to a vaccine, administered to healthcare workers, those in long-term care facilities, or anyone else exposed to an outbreak, with or without symptoms. Science Magazines Derek Lowe had a good roundup of the companies working to create and test these antibodies; some think those treatments will be available by the fall.

What treatments are there for the late stages of the disease?

Theres still a lot we dont know about the cytokine storm, but we do have some pretty good ways of slowing down the immune system. Obviously, we want to test these in the context of COVID-19.

The first one that showed significant results in a big study was tocilizumab. When given to patients in Stage 2, it reduced intensive care unit admission by more than half and significantly cut mortality as well.

It has problems though. Its incredibly expensive, in the thousands to tens of thousands of dollars to administer. It does really wreck a persons immune system for a while, putting them at risk of other infection. Its something that wed want to give to save lives, but probably not in large numbers.

Luckily, we found a much better solution. Dexamethasone is a cheap and widely available steroid that cut deaths by one-third in a study released this week of 2,100 participants in the UK with severe COVID-19. Its a pill. It costs about $6 per day.

You can see why the head scientist in the study called it a major breakthrough.

Now remember: this is an immune system suppressant. People with Stage 1 coronavirus definitely shouldnt take it, because itd be handicapping the very thing they need most. But those in later stages might find it effective in weathering the cytokine storm.

Just like with remdesivir, its also a proof of concept. Yes, we can save a third of deaths among severe cases, but now well try other immune-suppressing drugs with different doses to try to treat the cytokine storm most effectively. Well get better at it over time.

That will be the continuation of a positive coronavirus trend: a lowering in the fatality rate. One study looked at the rate of deaths of people in Italy and found a reduction in fatality rate from 10.8% to 6% from March to April. Testing differences make this issue difficult to study, but it really does appear that doctors have gotten better at treating the disease.

That was another reason all of us have taken so many coronavirus precautions: to buy doctors time. While theyve done well with it reducing mortality by a third is no small feat its easy to see that more improvements are just around the corner.

One common refrain Ive heard from people who have shown a lack of care about the virus was Well, Im going to get it at some point, it might as well be now. But the truth is simple: its much better to be a coronavirus patient in June than March. Thats a trend I expect to continue moving forward.

Andy Larsen is a Tribune sports reporter who covers the Utah Jazz. During this crisis, he has been assigned to dig into the numbers surrounding the coronavirus. You can reach Andy at alarsen@sltrib.com or on Twitter at @andyblarsen.

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Coronavirus treatments are improving. Here's a guide to what works and why. - Salt Lake Tribune

Express News Service

BENGALURU: Chocolates with ashwagandha, ginger or cumin; potato wedges with moringa leaves; a white rum pina colada with turmeric... Restaurants and cafes in Bengaluru are coming up with innovations to show that diners can actually get a host of health benefits in these pandemic-ridden times.

Many are now turning towards local ingredients for their immunity-boosting properties, with pepper, amla and chia seeds joining the list of condiments as the new stars of their dishes. According to food writer and consultant Monika Manchanda, in the last 15-20 days alone, a couple of clients have reached out to her for help with new recipes to include on their menu.

"And those who arent coming up with new dishes, are highlighting the immunity-boosting ingredients in their existing ones," she says, adding that she has recently helped a Bengaluru eatery with a Golden Glow smoothie that contains carrot, turmeric and ginger.

Antioxidants in dark chocolates are, of coursem said to be good for the immune system. But in light of the coronavirus spread, Smoor Chocolates has decided to further infuse their chocolates with ashwagandha, and come July, will offer customers variants with pecan nuts, goji berries, turmeric, ginger, amla and cumin.

Agreeing that these are not ideas one might stomach easily, chief marketing officer Kanchan Achpal hopes that people will develop a taste for it anyway since boosting ones immunity is the need of the hour. "People tend to be hesitant about such combinations but come to eventually enjoy it," she says. Case in point: The turmeric latte they introduced earlier this month.

Currently, the Indiranagar outlet receives 10-12 orders for this, as opposed to 30-35 orders for their regular latte.Agrees Nidhi Nahata, founder of JustBe Resto Caf, who is hoping to reopen her eatery for dine-in in July.

New offerings include a salad bar (with 50 varieties), potato wedges with moringa leaves, hemp hearts in milkshakes, hemp powder in chapati and pizza dough, and avocado chocolate mousse. "Right now, people have been cooking more and becoming more aware of what to eat. So such dishes will only be in demand," says Nahata, who is also a health coach and food therapist.

While the ingredients to experiment with are plenty, nothing beats the crowning glory of the golden spice. Having always been famous in its haldi doodh form (Chaayos has also introduced a haldi chai on its menu), turmeric has even managed to find its way into alcoholic drinks at The Leela Palace, Bengaluru.

The star hotel will offer diners a turmeric pina colada once restaurants get a go-ahead to serve liquor, with its team having spent the last few weeks coming up with a menu of 12 new drinks (eight cocktails and three welcome drinks) with amla, hibiscus, tulsi, etc.

"Turmeric powder tended to overpower the drink, so we settled for a crushed decoction of it that blends well with the drink. The taste of pineapple, coconut and white rum remains the same, with just enough spice to get its health benefits as well," says F&B manager Mark Manuel.

On the menu

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Taste of times: Bengaluru eateries launch dishes with immunity boosting ingredients - The New Indian Express

Immunity Booster Drink: Kadha is basically a mix of various traditional herbs and spices

Highlights

Immunity Booster Drink: As the world is under a constant threat of Covid-19 pandemic, health experts are time and again insisting on boosting our immunity. Although it has not been proved whether strong immunity helps in treating the novel Coronavirus or not, it may help you have an overall better health. While some people are blessed with good immunity, others are resorting to various natural ways to strengthen their stamina, immune system and overall health. Many of us are practicing regular yoga, breathing exercises and more and even trying natural concoctions like herbal teas, drinks and kadhas.

Speaking about kadha, it will not be an exaggeration if we term it to be one of the oldest and treasured medicinal secrets of India. It is basically a mix of various traditional herbs and spices that help us to keep strong from within.

Here we bring you an easy immunity-boosting kadha recipe that can be prepared with some common herbs and spices like tulsi, ginger, turmeric, mulethi, cinnamon, black pepper and cloves. The best part is you can prepare and store it for future use. All these herbs and spices are power packed with various health benefiting nutrients and can be found easily in any Indian kitchen.

Also Read:This Moon Milk At Night May Help Induce Good Sleep

Ginger- 1 inch

Raw turmeric- 1 inch

Tulsi- 8-10

Mulethi- 4-5 sticks

Cinnamon- 4-5 sticks

Black pepper- 10-12

Cloves- 10-12

Water- 8-10 cups

Step 1. Pour the water in a saucepan and put all the ingredients in it.

Step 2. Boil it for at least 1 hour in a low/medium flame.

Step 3. Switch off the flame and cool it down.

You can store this kadha for 2 days in refrigerator. All you need to do is, strain the drink in a sterilised airtight glass bottle and close the lid well. Warm it well before drinking. Do not warm the whole thing; just take as much you need.

Pro-tip: You may also add some green tea, lemon and honey while warming this kadha for consumption.

Stay healthy, stay safe!

About Somdatta SahaExplorer- this is what Somdatta likes to call herself. Be it in terms of food, people or places, all she craves for is to know the unknown. A simple aglio olio pasta or daal-chawal and a good movie can make her day.

Originally posted here:
Kadha For Immunity: Prepare This Herbal Potion With Basic Indian Herbs And Spices - NDTV Food

Chronic stress can lead to inflammation, which can result in physical symptoms as well as mental health symptoms

During the current COVID-19 pandemic have you been wondering why youre getting headaches more often? Or stomach aches? Or feeling itchy or getting pimples? Or why your periods are irregular or more painful than usual? Exciting recent science suggests that the answers may lie in our bodys biological reactions to stress.

Our biological stress response system the hypothalamic-pituitary-adrenal (HPA) axis evolved hundreds of millions of years ago to help our vertebrate ancestors quickly mobilize energy to confront imminent, life-or-death threats, such as predator attacks. In the short term, this system is exquisite in its efficiency and crucial to survival.

The problem with our current situation is that it has been going on for months, and the end is not clearly in sight. Chronic stress sends the HPA axis into overdrive, with effects felt throughout the body. These symptoms can even serve as further sources of stress. Understanding why our bodies are reacting in these ways can help us develop strategies to prevent stress from getting under our skin.

The biological stress response

When animals perceive a threat in their environment, the HPA axis stimulates the adrenal glands to release the hormone cortisol. Cortisol, along with adrenaline, work to pump oxygen to the major muscles to enable the animal to fight or escape.

This fight/flight response produces physical symptoms such as heart palpitations and chest tightness (the heart pumping oxygen to the major muscles), and stomach butterflies, nausea and tingling (blood leaving the stomach and extremities to get to the major muscles).

The HPA axis also interacts with the immune system to help with the aftermath. Cortisol is a potent anti-inflammatory and binds to large numbers of receptors in the skin to help repair wounds and fight infection.

The HPA axis doesnt know the difference between the life-or-death threat of a predator attack and modern stressors. So, in the early stages of this crisis, if your stomach did flip-flops, or you felt your heart racing, when reading about surges in COVID-19 cases, your body was doing what it was designed to do even though at that moment you were not in any imminent physical danger.

The problem of chronic stress

A predator attack is time-limited. In contrast, the COVID-19 pandemic has been going on for weeks, and may be compounded by social isolation, job or financial insecurity and care-taking responsibilities. Unfortunately, all the HPA axis knows is that it needs to release stress hormones when we perceive a threat in our environment. So, if we perceive our environment as threatening all the time, then the HPA axis will release these chemicals all the time.

One of the most pronounced effects of long-term cortisol release is glucocorticoid resistance. This is when cells in the immune system become less sensitive to the anti-inflammatory effects of cortisol. As a result, cortisol starts to increase inflammation throughout the body and brain.

So, your itchiness and rashes? All of the cortisol receptors in your skin may no longer be receptive to cortisols anti-inflammatory effects and instead, chemicals are released that inflame the skin.

Your headaches or stomach aches? Painful periods? All of these symptoms can also be the result of inflammation in these organ systems caused by chronic HPA axis activation.

Even psychological symptoms, such as feelings of depression or loneliness, have been linked to the release of pro-inflammatory chemicals caused by chronic stress.

Taking control of your stress response

Much of what is perceived as stressful on a day-to-day level is not specific to contracting the COVID-19 virus, but instead is the result of changes that we have had to make in our lives. A switch to working from home, or not working, has disrupted our sleeping, eating and activity schedules that regulate our internal circadian clock. Staying indoors means lower exercise and activity levels. Many people, especially those living alone, are socially isolated from friends and loved ones.

Disrupted circadian routines, lack of exercise and social isolation have all been strongly linked to dysregulation of the bodys stress and immune systems, and release of pro-inflammatory chemicals in the body and brain.

Fortunately, even small positive changes in these areas can have strong stress-reducing effects. Keeping a regular routine by going to bed, getting up and eating at consistent times each day has been linked to greater overall health by promoting healthy function of the HPA axis and immune system. Even 20 minutes of moderate exercise, which inside could include exercise videos or jogging around at home, regulates the HPA axis, reduces inflammation and has strong mood-lifting effects.

Finally, talking regularly with friends and loved ones, even remotely or at a distance, is one of the best things you can do to protect against the biological and psychological effects of stress. Remember, were all in this together!

Kate Harkness, Professor of Psychology and Psychiatry and Director of the Mood Research Laboratory, Queen's University, Ontario

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Strange physical symptoms? Blame the chronic stress of isolation - KitchenerToday.com

By: Lifestyle Desk | New Delhi | Updated: June 21, 2020 1:35:28 pm Are you including these important vitamins and minerals in your diet? (Photo: Getty)

While vitamins and minerals wont immediately turn you into a virus-fighting superhero but consuming them is extremely beneficial for your body and overall health. The current time has surely made us concerned about what we eat and how we can improve our diet. Ahead, take a look at these five important vitamins and minerals that make a world of difference when you consume them over time. They are known to increase immunity and fight infections.

READ| These 2-morning drinks will help you boost your immunity

1. Vitamin D: Vitamin D, which is found in eggs, fish, chicken and cod liver oil, is one of the most important vitamins and plays a crucial role in the activation of your immunity system whenever theres an exposure to pathogen-like viruses or bacteria. So its important to check your vitamin D levels and take the right supplements accordingly, says Dr Rohini Somnath Patil, MBBS, nutritionist.

However, the best source of this vitamin is when you are exposed to sunlight. The UV rays induce the body to manufacture Vitamin D from cholesterol present in your body. She mentions, The amount of sunlight needed ranges from about five to 20 minutes twice a week.

2. Vitamin C: Vitamin C is what makes your immune system strong. Make sure you consume Vitamin C rich foods like amla, lemon, kiwi, mangoes, oranges, etc. Vitamin C, also called ascorbic acid, is a potent anti-oxidant and co-factors many enzymes in our body. It holds a reputation as an immune system booster, says Dr Somnath.

READ| 5 superfoods to boost your immunity

3. Vitamin E: Vitamin E is a powerful antioxidant that helps your body fight off infections too. Almonds, peanuts, hazelnuts and sunflower seeds are rich sources of Vitamin E.

4. Magnesium and zinc: Along with vitamin D and C, magnesium and zinc are minerals which play a crucial role in carrying out the enzymatic processes in our body, mentions Dr Somnath. Magnesium helps in converting vitamin D into its active usable form and zinc has an anti-inflammatory action in our body. This protects our body and responds to immune damage. In fact, even chocolates contain a good dose of magnesium and release feel-good hormones.

5. Selenium: Selenium seems to have a powerful effect on the immune system, including the potential to slow the bodys over-active responses to certain aggressive forms of cancer, says the doctor. Make sure you get your dosage by consuming garlic, broccoli, sardines, tuna and barley.

READ| Turn to these traditional immunity boosters for better health

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Are you including these 5 vitamins and minerals in your diet to boost immunity? - The Indian Express

The Covid-19 pandemic has turned the world upside down, bringing about an unprecedented new world order. We are all plagued by uncertainty, knowing that things will never be the same as they were before. However, there are things we can do to stay in control.

The World Digestive Health Day 2020 is a reminder for us to take care of our gut. We have all heard of the saying health is wealth. If the body is a temple, then the gut is the foundation of that temple.

Hippocrates once said that all disease begins in the gut. Housing trillions of both good and bad bacteria, the composition of bacteria in the gut environment, known as the microbiome, greatly affects both physical and mental well-being.

Understanding Gut Bacteria

The good bacteria known as probiotics, work with our cells to keep us healthy. Apart from discouraging and fighting off harmful, invading organisms, the good bacteria also work to support our digestion, nutrient absorption and immune system.

Studies have also indicated that mental health and emotions are closely linked to gut health. We have already established that good gut health is the cornerstone of good health, but what is the key to good gut health?

Just as how Malaysians have adapted to the new normal of social distancing and the wearing of face masks, we need to take the necessary steps to maintain good gut health. Photo: Cotra Enterprise Sdn Bhd

The term probiotics is nothing new today. Thanks to its function of restoring gut bacteria to healthy levels, probiotics have increased in popularity in recent years.

In 2017, a local landmark clinical research conducted by Pusat Perubatan Universiti Kebangsaan Malaysia titled Modulation Of Intestinal Dysbiosis In Patients With Constipation-Predominant Irritable Bowel Syndrome Using Lactobacillus-Containing Cultured Milk Drink and published in Clinical Gastroenterology in 2018, demonstrated the efficacy of two probiotic strains Lactobacillus acidophilus and Lactobacillus paracasei which are found in Vitagen, to have a positive impact on gut health and the immune system.

Statistically speaking, 96% of respondents showed significant improvement in relieving constipation while 45% of respondents required a shorter time to defecate. The study also showed that by consuming the probiotics contained in Vitagen, the body produces less pro-inflammatory chemicals, which reduces inflammation and enhances the immune system.

Reality Check To Managing Our Lifestyles

It goes without saying that living a healthy lifestyle is our single best defence against harmful bacteria and viruses. Every part of the body can benefit from a healthy diet, sufficient sleep and a positive, stress-free environment all of which help promote a stronger immune system that stems from the gut.

Malaysians are constantly surrounded by unhealthy food options, so it is crucial to boost gut health with probiotics and foods that will naturally help build up our immune systems. Photo: Cotra Enterprise Sdn Bhd

However, it is not always easy to stay healthy. We are all guilty of excessively eating unhealthy foods, sometimes on a regular basis. Add a sedentary lifestyle to the mix and it is likely that you are increasing your risk of developing various digestive disorders or diseases such as inflammatory bowel disease and many non-communicable diseases such as hypertension and heart disease.

For many, the pandemic is a wake-up call to start taking health seriously. We need to stop abusing our bodies and start boosting our gut health with probiotics and foods that will naturally help build up our immune systems.

Daily consumption of probiotics is easy with Vitagen. It is delicious to drink and contains billions of live probiotic cultures that are clinically proven to be beneficial to gut health. It is recommended that you take at least two bottles of Vitagen daily for best results.

Vitagen contains two beneficial probiotic strains to boost gut health and help prevent disease. Photo: Cotra Enterprise Sdn Bhd

This new normal that we are facing may last for quite some time. We have all been inundated with enough information on the seriousness of this pandemic, but how many of us are actually doing something about it from a health standpoint? We need to ponder this question.

In every crisis, there is opportunity. We have two options: one is to go back to our old, unhealthy ways and take life for granted. The second is to re-evaluate our habits and cultivate new, healthy ones that will stay with us for life. Without our health, we are nothing, and that is something that should never be taken for granted.

For more information, visit vitagen.com.my.

Go here to read the rest:
Taking Care Of Your Gut Is Key To Stronger Immunity - The Star Online

From the first reports coming out of Wuhan, Iran and later Italy, we knew that losing your sense of smell (anosmia) was a significant symptom of the disease. Now, after months of reports, both anecdotal and more rigorous clinical findings, we think we have a model for how this virus may cause smell loss.

One of the most common causes of smell loss is a viral infection, such as the common cold, sinus or other upper respiratory tract infections. Those coronaviruses that don't cause deadly diseases, such as COVID-19, SARS and MERS, are one of the causes of the common cold and have been known to cause smell loss.

In most of these cases, sense of smell returns when symptoms clear, as smell loss is simply the result of a blocked nose, which prevents aroma molecules reaching olfactory receptors in the nose. In some cases, smell loss can persist for months and years.

For the novel coronavirus (SARS-CoV-2), however, the pattern of smell loss is different. Many people with COVID-19 reported a sudden loss of sense of smell and then a sudden and full return to a normal sense of smell in a week or two.

Interestingly, many of these people said their nose was clear, so smell loss cannot be attributed to a blocked nose. For others, smell loss was prolonged and several weeks later they still had no sense of smell. Any theory of anosmia in COVID-19 has to account for both of these patterns.

This sudden return of a normal sense of smell suggests an obstructive smell loss in which the aroma molecules cannot reach the receptors in the nose (the same type of loss one gets with a clothes peg on the nose).

Now that we have CT scans of the noses and sinuses of people with COVID-19 smell loss, we can see that the part of the nose that does the smelling, the olfactory cleft, is blocked with swollen soft tissue and mucus known as a cleft syndrome. The rest of the nose and sinuses look normal and patients have no problem breathing through their nose.

Location of the olfactory bulb. (medicalstocks/iStock/Getty Images Plus)

We know that the way SARS-CoV-2 infects the body is by attaching to ACE2 receptors on the surface of cells that line the upper respiratory tract. A protein called TMPRSS2 then helps the virus invade the cell.

Once inside the cell, the virus can replicate, triggering the immune system's inflammatory response. This is the starting point for the havoc and destruction that this virus causes once in the body.

Initially, we thought that the virus might be infecting and destroying the olfactory neurons. These are the cells that transmit the signal from the aroma molecule in your nose to the area in the brain where these signals get interpreted as "smell".

Olfactory neuron [pink] with protruding smell receptors. (Steve Gschmeissner/Getty Images)

However, an international collaboration showed recently that the ACE2 proteins the virus needs to invade the cells were not found on the olfactory neurons. But they were found on cells called "sustentacular cells", which support the olfactory neurons.

We expect that these support cells are likely to be the ones that are damaged by the virus, and the immune response would cause swelling of the area but leave the olfactory neurons intact. When the immune system has dealt with the virus, the swelling subsides and the aroma molecules have a clear route to their undamaged receptors and the sense of smell returns to normal.

So why does smell not return in some cases? This is more theoretical but follows from what we know about inflammation in other systems. Inflammation is the body's response to damage and results in the release of chemicals that destroy the tissues involved.

When this inflammation is severe, other nearby cells start to be damaged or destroyed by this "splash damage". We believe that accounts for the second stage, where the olfactory neurons are damaged.

Recovery of smell is much slower because the olfactory neurons need time to regenerate from the supply of stem cells within the lining of the nose.

Initial recovery is often associated with distortion of the sense of smell known as parosmia, where things don't smell like they used to. For many parosmics, for instance, the smell of coffee is often described as burnt, chemical, dirty and reminiscent of sewage.

Olfaction has been called the Cinderella of the senses because of its neglect by scientific research. But it has come to the forefront in this pandemic. The silver lining is that we will learn a lot about how viruses are involved in smell loss from this. But what hope is there for people with a loss of smell now?

The good news is that the olfactory neurons can regenerate. They're regrowing in almost all of us, all of the time. We can harness that regeneration and guide it with "physiotherapy for the nose": smell training.

There is solid evidence that many forms of smell loss are helped by this repeated, mindful exposure to a fixed set of odorants every day and no reason to think it won't work in COVID-19 smell loss.

Simon Gane, Consultant Rhinologist and ENT surgeon, City, University of London and Jane Parker, Associate Professor, Flavour Chemistry, University of Reading.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

See the original post:
COVID-19 Can Cause Loss of Smell, And Scientists Finally Discovered Why - ScienceAlert

To develop and more importantly to improve current technologies, the market needs a pipeline of talent: well-educated and skilled scientists. Today, a new graduate or scientist with an immunology background will have a strong advantage in the market.

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The market for NGS applications reached $2.7 billion in 2016 and is expected to expand to $10.5 billion by 2022.

The expanding biotech market offers a variety of careers. In some cases, we need to be creative and see behind the obvious scientific path.

Report Scope:

Finding the right career path is one of the biggest challenges in every persons life. We want to make sure we make the right choices and decisions concerning our future employment opportunities. And its no longer a one-time decision. Employment conditions and opportunities are not constantly evolving and this requires us to update our skill set and knowledge base on a continual basis.

This analysis of current and emerging trends in the market can be helpful in making the right decision based on your personality, education and other skills. In our dynamic and constantly evolving world, in order to succeed, a person needs to understand what potential future directions the job market might take and how novel technologies will affect the need to change ones career track or train for a new career path.

Trends described below will help readers navigate the evolving biotech market to choose the right direction.

Immuno-oncology, a Future in Cancer Treatment

It is obvious that the immune approach to treat cancer or so-called cancer immunotherapy has become the next big thing. Recent drug development trends show that immunotherapy can be more effective and efficient than traditional chemotherapies.

Cancer immunotherapy/immuno-oncology is defined as artificial stimulation of the immune system to treat cancer, thus improving ones natural ability to fight this disease. This approach exploits the fact that cancer cells have specific tumor antigens that can be detected by the antibody proteins of the immune system. Normal antibodies bind to external pathogens; however, modified immunotherapy antibodies bind to the tumor antigens. This helps the immune system to inhibit or kill cancer cells.

Repot Includes:

An overview of the emerging and growing trends in life science/biotech industry as potential career track Why understanding CRISPR technology can be an important skill in career development Information on genomics data management and its role in creating jobs for genomics and genetics specialized students Coverage of artificial intelligence and drug discovery job market Insights of nanotechnology applications and evaluation of their role in biomedical engineering jobs List of potential career pathways for biotech/pharma professionals

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Summary

Finding the right career path is one of the biggest challenges in every persons life. We want to make sure we make the right choices and decisions concerning our future employment opportunities. And its no longer a one-time decision. Employment conditions and opportunities are not constantly evolving and this requires us to update our skill set and knowledge base on a continual basis.

This analysis of current and emerging trends in the market can be helpful in making the right decision based on your personality, education and other skills. In our dynamic and constantly evolving world, in order to succeed, a person needs to understand what potential future directions the job market might take and how novel technologies will affect the need to change ones career track or train for a new career path.

Trends described below will help readers navigate the evolving biotech market to choose the right direction.

Immuno-oncology, a Future in Cancer Treatment

It is obvious that the immune approach to treat cancer or so-called cancer immunotherapy has become the next big thing. Recent drug development trends show that immunotherapy can be more effective and efficient than traditional chemotherapies.

<<< Get COVID-19 Report Analysis >>>https://www.trendsmarketresearch.com/report/covid-19-analysis/11616

Cancer immunotherapy/immuno-oncology is defined as artificial stimulation of the immune system to treat cancer, thus improving ones natural ability to fight this disease. This approach exploits the fact that cancer cells have specific tumor antigens that can be detected by the antibody proteins of the immune system. Normal antibodies bind to external pathogens; however, modified immunotherapy antibodies bind to the tumor antigens. This helps the immune system to inhibit or kill cancer cells.

Read more from the original source:
Emerging Jobs In Life Sciences And What You Should Be Training For Now Market Growth Opportunities Created by Covid19 Outbreak - Cole of Duty

Medipost CEO Yang Yoon-sun (Lim Jeong-yeo/The Korea Herald)

Her journey as a professor of pathology at Samsung Medical Center to head of a cord blood stem cell research company at the age of 37 came with prejudices, challenges and pitfalls, but also with encouragement, conviction and immense potential.

Cord blood is that inside the umbilical cord that connects the baby and mother, and can be ethically, and legally, procured after a babys birth. Despite containing one of the most potent types of stem cell and possibilities for vast medicinal repurposing, cord blood has often been discarded due to a lack of technology to refine it, Yang said.

In 2000, the concept of processing raw cord blood for stem cell therapies was still in a nascent stage across the world.

Soon Yang came to realize that research on cord blood should be approached commercially rather than academically to fast-track the development of consequential treatments.

The conviction was supported by her colleagues, and further fostered by a nationwide boom in startups.

Yang met obstetricians and gynecologists nationwide to help persuade laboring mothers to donate the otherwise unusable blood.

Medipost humbly started out in a rented laboratory of a Doosan Group research facility in Yongin, Gyeonggi Province, on June 26, 2000.

The company soon got listed on Koreas tech-heavy secondary bourse Kosdaq in 2005. In 2019, the company posted roughly 45.8 billion won ($37.9 million) in revenue with a net loss of over 14.1 billion won.

Medipost now operates from a self-owned building with 14 levels in the biocluster of Pangyo, Seongnam in Gyeonggi Province. Some 200 full-time employees work for Medipost, with entities strewn in global locations such as the US, China and Japan.

It has seven subsidiaries, three of which are Medipost America, Shandong Orlife Pharmaceutical and Evastem Corp., located overseas in the US, China and Japan, respectively.

Medipost, the embodiment of Yangs visions, has three business pillars: its cord blood bank, cell therapy developments and health supplements.

The companys main revenue source is the cord blood bank, where over 259,000 children have their cord blood stored, with more being added. It roughly costs around 1.4 million won to store a vial containing cord blood for 15 years, and 4 million won to store it for a lifetime.

Celltree cord blood bank (Medipost)

Most recently, Winter Sonata actor Choi Ji-woo decided to store the cord blood of her first daughter, whom she gave birth to at age 45.

It was not always a smooth ride, as soon after the companys initial public offering, there broke out the ethical scandal of embryonic stem cell research that clouded the general perception of stem cell research in the public eye. More than once the companys revenue has taken a dive of 50 percent.

However, Yang has no regrets.

As for me, every step was an unexpected challenge and overcoming each hardship taught me to be prepared for anything to maintain business stability, Yang said in an interview with The Korea Herald.

Cord blood, Yang said, is an immune response-safe therapeutic insurance in case the children and their families face incurable diseases such as leukemia, refractory anemia, immune disorders, cerebral palsy, developmental disorders or various forms of cancer.

If the babys cord blood is used to treat the same baby, it would be called an autologous therapy. If used for another family member, that is an allogenic therapy.

Cartistem, an allogenic osteoarthritis treatment that was approved by the local Drug Ministry in 2012, is the next biggest contributor to Mediposts business growth, as well as a balm to the knee problems of seniors.

Celltree cord blood bank (Medipost)

Cartistem is a stem cell therapeutic agent for cartilage regeneration crafted from Mediposts pool of research-purpose cord blood. Once surgically applied to the affected region, the drug has been successful in triggering regrowth of knee cartilage in 98 percent of the 103 patients treated in clinical phase 3 trials.

Medipost counts over 16,000 patients who have so far benefited from the use of Cartistem in the eight years the drug has been in service. It is prescribed at some 550 hospitals here.

The therapy has currently finished clinical phase 1 and 2a trials in the US to launch there, and is pending phase 2 clinical trials in Japan with aims to start tests in July. As it would require a great volume of funding to carry out wide-scale clinical phase 3 trials in the US, it might be Japan where Cartistem launches first, Yang said.

SK Bioland, an SK Group subsidiary, in-licensed Cartistems indication for ankle joint inflammation at end-2019 to carry out clinical phase 3 trials and have full domestic rights to the drugs use for ankle therapy.

Other than Cartistem, Medipost has Pneumostem, Neurostem and SMUP-Cell injections under developments.

Pneumostem is a stem cell therapy for prematurely born babies lung fibrosis. Unlike adult lung fibrosis, which has numerous causes and is sometimes isolated, newborn babies lung problems have a singular cause and therefore a clearer path of tackling it.

Pneumostem is undergoing clinical phase 2 trials in Korea and has completed phase 1 and 2 clinical trials in the US. It has been designated by the US Food and Drug Administration and the European Medicines Agency as an orphan drug, granting it government assistance as it would otherwise prove unprofitable due to its limited scope, and it has the FDAs fast track designation. Once its efficacy is proved, it may attempt to expand Penumostems indications to other forms of lung inflammation, including COVID-19, Yang said.

Neurostem is a proposed Alzheimers disease stem cell therapy. It is believed to promote the degradation of beta-amyloid, and accumulation in the brain is believed to cause Alzheimers-type dementia. The pipeline has completed phase 1 and 2a clinical trials in Korea, and has been cleared for the FDAs phase 1 and 2 investigational new drug application.

SMUP-Cell, an injectable type innovative knee joint treatment, saves patients the trouble of undergoing intrusive surgery. Medipost has finished administrating the cell therapy to the first round of clinical phase 1 trials and has begun the five-year tracking of patients progress. If the drug makes it to commercial stage, it would be a groundbreaking solution for patients of joint inflammation who are in pain, but not at the stage yet to go under the knife.

At its basement in Pangyo, Medipost has enough space to install more cord blood tanks to last the next 20 years.

Our only goal should be to provide stem cell regenerative therapy to patients whose predicament previously had no life-extending solution. If we save one patient -- while to us it may just be one person, it is 100 percent to the patient themselves. That is our step-by-step approach, said Yang.

By Lim Jeong-yeo (kaylalim@heraldcorp.com)

Read more from the original source:
[Herald Interview] Spinning cord blood into stem cell therapies - The Korea Herald

Global Stem Cell Therapy Market report is aimed at highlighting a first-hand documentation of all the best practices in the Stem Cell Therapy industry that subsequently set the growth course active. These vital market oriented details are highly crucial to overcome cut throat competition and all the growth oriented practices typically embraced by frontline players in the Stem Cell Therapy market. Various factors and touch points that the research highlights in the report is a holistic, composite amalgamation of product portfolios of market participants, growth multiplying practices and solutions, sales gateways as well as transaction modes that coherently reflect a favorable growth prospect scenario of the market.

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In addition, study report offers an array of opportunities for the players participating in the industry. This ultimately leads into the growth of the global Stem Cell Therapy market. Furthermore, report offers a comprehensive study on market size, revenue, sales, growth factors and risks involved in the growth of the market during the forecast period. The factors which are influencing the growth the market are mentioned in the report as well as the challenges which can hamper the growth of the market over the forecast period.

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The research report encourages the readers to comprehend the importance of quality, shortcomings if any and deep investigation for every member independently by giving the global data of great importance about the market. Consequently, the research report presents the organization profiles and deals investigation of the considerable number of vendors which can assist the customers with taking better choice of the products and services. The end clients of the global Stem Cell Therapy market can be sorted based on size of the endeavour. This research report presents the open doors for the players of the global Stem Cell Therapy market. It additionally offers plans of action which can be taken and market conjectures that would be required.

Global Stem Cell Therapy market is segmented based by type, application and region.

Based on Type, the market has been segmented into:

Based on cell source, the market has been segmented into,

Adipose Tissue-Derived Mesenchymal SCsBone Marrow-Derived Mesenchymal SCsEmbryonic SCsOther Sources

Based on application, the market has been segmented into:

Based on therapeutic application, the market has been segmented into,

Musculoskeletal DisordersWounds & InjuriesCardiovascular DiseasesGastrointestinal DiseasesImmune System DiseasesOther Applications

The company profile section also focusses on companies planning expansions along with mergers & acquisitions, new initiatives, R&D updates and financial updates. But, one of the most important aspects focused in this study is the regional analysis. Region segmentation of markets helps in detailed analysis of the market in terms of business opportunities, revenue generation potential and future predictions of the market. For Stem Cell Therapy market report, the important regions highlighted are North America, South America, Asia, Europe and Middle East. The companies focused on in this report are pioneers in the Stem Cell Therapy market. The uplifting of any region in the global market is dependent upon the market players working in that region.

A qualitative and quantitative analysis of the Stem Cell Therapy market valuations for the expected period is presented to showcase the economic appetency of the global Stem Cell Therapy industry. In addition to this, the global research report comprises significant data regarding the market segmentation which is intended by primary and secondary research methodologies. This research report offers an in-depth analysis of the global Stem Cell Therapy industry with recent and upcoming market trends to offer the impending investment in the Stem Cell Therapy market. The report includes a comprehensive analysis of the industry size database along with the market prediction for the mentioned forecast period. Furthermore, the Stem Cell Therapy market research study offers comprehensive data about the opportunities, key drivers, and restraints with the impact analysis.

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Global Stem Cell Therapy Market 2020: Size, Share, Growth Rate, Revenue and Volume, Key-Players, Top Regions and Forecast Till 2025 - Cole of Duty

Animal Stem Cell Therapy Market

Global Animal Stem Cell Therapy MarketInsights, Forecast To 2026 provides a specific tool for evaluating the global market, specifying the growth potentials, and supporting tactical and strategic decision-making. This report identifies that in this quickly developing and competitive world, the latest marketing information is essential, in order to monitor performance and make strategic decisions for development and profitability. This report provides information on the overall market trends and development patterns, as well as focuses on the markets and materials, capacities and technologies, and on the dynamic nature of the Animal Stem Cell Therapy market.

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Key Manufacturers ofGlobalAnimal Stem Cell Therapy Market:MediVet Biologic, VETSTEM BIOPHARMA, J-ARM, Celavet, Magellan Stem Cells, U.S. Stem Cell, Cells Power Japan, ANIMAL CELL THERAPIES, Animal Care Stem, Cell Therapy Sciences, VetCell Therapeutics, Animacel, Aratana Therapeutics

Key Product TypeDogsHorsesOthers

Market by ApplicationVeterinary HospitalsResearch Organizations

Access your COVID-19 Animal Stem Cell Therapy Research Sample Guide. The report presents visionary insight into the major innovations impacting business operations, for instance, automation, artificial intelligence, blockchain, advanced tech business models and smart analytics. Further, the study expects the protracted recession to challenge investors growth, and the impact of the COVID-19 pandemic to vary by business line. The Animal Stem Cell Therapy market is expected to face declining growth prospects and rising costs for the market products, driven by disrupted supply chain.

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2013

2019

2026

Share (%)

Scope of GlobalAnimal Stem Cell Therapy Market:This report assesses the growth rate and the market value on the basis of the key market dynamics, as well as the growth inducing factors. The complete study is based on the up-do-date industry news, growth potentials, and market trends. It also contains an in-depth analysis of the market and competitive scenario, together with the SWOT analysis of the leading competitors.

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Table of Content:

This research study consists of the historical data from 2011 to 2019 and forecasts until 2026, which makes it a valuable source of information for all the individuals looking for relevant market information in readily accessible documents with clearly presented graphs and statistics, including but not limited to the stakeholders.

Reasons for Buying this Report

About Us:We, Regal Intelligence, aim to change the dynamics of market research backed by quality data. Our analysts validate data with exclusive qualitative and analytics driven intelligence. We meticulously plan our research process and execute in order to explore the potential market for getting insightful details. Our prime focus is to provide reliable data based on public surveys using data analytics techniques. If you have come here, you might be interested in highly reliable data driven market insights for your product/service,reach us here 24/7.

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Animal Stem Cell Therapy Market Exhaustive Analysis Strategic Assessment and Forecast Till 2026 - Owned

Global Stem Cell Therapy for Osteoarthritis Market 2020 by Company, Regions, Type and Application, Forecast to 2025 aims to project the value and volume of the market and strategically profile the key players, analyze their growth strategies. The report delivers in-depth data and study of the industry dynamics of this market. The report offers an overview of global Stem Cell Therapy for Osteoarthritis market division like type, application, and region. The market report dynamics trends are made up of opportunities and challenges. The report provides a structure of the market and predicts industry share to rise within the forecast period 2025. The research thoroughly estimates the consumption volume industry by application, manufacturing technology and regions. Further, conclusion, discoveries, and future improvement openings are explored in the report.

The market report opens with an overview of the global Stem Cell Therapy for Osteoarthritis industry, which contains definitions and specifications about the industry. In the next chapter, the report explains the manufacturing cost structure, which includes a thorough analysis of the raw material suppliers and price analysis, equipment suppliers and price analysis, and analysis of labour costs and other costs. The manufacturers have been incorporated in terms of their manufacturing base, basic information, and competitors.

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Our best analysts have surveyed the market report with the reference of inventories and data given by the key players: Mesoblast, Anterogen, Regeneus, U.S. Stem Cell, Asterias Biotherapeutics

On the basis on the applications, this report focuses on the status and outlook for major applications/end users, sales volume, and growth rate for each application, including: Osteoarthritis (unspecified), Knee Osteoarthritis, Shoulder Osteoarthritis, Hip Osteoarthritis,

On the basis of types/products, this report displays the revenue (Million USD), product price, market share, and growth rate of each type, split into: Monotherapy, Combination Therapy,

Key Issues Addressed by Market:

It is very significant to have global Stem Cell Therapy for Osteoarthritis segmentation analysis to figure out the essential factors of growth and development of the market. The report provides well summarized and reliable information about every segment of growth, development, production, demand, types, application of the specific product which will assist players to focus and highlight on.

Moreover, each geographic segment of the global Stem Cell Therapy for Osteoarthritis market has been independently surveyed along with pricing, distribution and demand data for geographic market notably: North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, etc.), Middle East& Africa (Saudi Arabia, Egypt, Nigeria and South Africa)

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Global Stem Cell Therapy for Osteoarthritis Market 2020: Expected Development, Share, Demand And Study Of Key Players- Research Predictions 2025 -...

New Jersey, United States,- The report is a must-have for business strategists, participants, consultants, researchers, investors, entrepreneurs, and other interested parties associated with the Stem Cell Therapy Market. It is also a highly useful resource for those looking to foray into the Stem Cell Therapy market. Besides Porters Five Forces and SWOT analysis, it offers detailed value chain assessment, comprehensive study on market dynamics including drivers, restraints, and opportunities, recent trends, and industry performance analysis. Furthermore, it digs deep into critical aspects of key subjects such as market competition, regional growth, and market segmentation so that readers could gain sound understanding of the Stem Cell Therapy market.

The research study is a brilliant account of macroeconomic and microeconomic factors influencing the growth of the Stem Cell Therapy market. This will help market players to make appropriate changes in their approach toward attaining growth and sustaining their position in the industry. The Stem Cell Therapy market is segmented as per type of product, application, and geography. Each segment is evaluated in great detail so that players can focus on high-growth areas of the Stem Cell Therapy market and increase their sales growth. Even the competitive landscape is shed light upon for players to build powerful strategies and give a tough competition to other participants in the Stem Cell Therapy market.

The competitive analysis included in the report helps readers to become aware of unique characteristics of the vendor landscape and crucial factors impacting the market competition. It is a very important tool that players need to have in their arsenal for cementing a position of strength in the Stem Cell Therapy market. Using this report, players can use effective business tactics to attract customers and improve their growth in the Stem Cell Therapy market. The study provides significant details about the competitive landscape and allows players to prepare for future challenges beforehand.

Stem Cell Therapy Market Segmentation

This market has been divided into types, applications and regions. The growth of each segment provides a precise calculation and forecast of sales by type and application, in terms of volume and value for the period between 2020 and 2026. This analysis can help you develop your business by targeting qualified niche markets. . Market share data are available at global and regional levels. The regions covered by the report are North America, Europe, Asia-Pacific, the Middle East and Africa and Latin America. Research analysts understand competitive forces and provide competitive analysis for each competitor separately.

Stem Cell Therapy Market by Type:

YYYY

Stem Cell Therapy Market by Application:

ZZZZ

Stem Cell Therapy Market by Region:

North America (The USA, Canada, and Mexico)Europe (Germany, France, the UK, and Rest of Europe)Asia Pacific (China, Japan, India, and Rest of Asia Pacific)Latin America (Brazil and Rest of Latin America.)Middle East &Africa (Saudi Arabia, the UAE, South Africa, and Rest of Middle East & Africa)

The report answers important questions that companies may have when operating in the Stem Cell Therapy market. Some of the questions are given below:

What will be the size of the Stem Cell Therapy market in 2026?

What is the current CAGR of the Stem Cell Therapy market?

What products have the highest growth rates?

Which application is projected to gain a lions share of the Stem Cell Therapy market?

Which region is foretold to create the most number of opportunities in the Stem Cell Therapy market?

Which are the top players currently operating in the Stem Cell Therapy market?

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What are the common business tactics adopted by players?

What is the growth outlook of the Stem Cell Therapy market?

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Table of Contents

Market Overview: This section comes under executive summary and is divided into four sub-sections. It basically introduces the Stem Cell Therapy market while focusing on market size by revenue and production, market segments by type, application, and region, and product scope.

Competition by Manufacturers: It includes five sub-sections, viz. market competitive situation and trends, manufacturers products, areas served, and production sites, average price by manufacturers, revenue share by manufacturers, and production share by manufacturers.

Market Share by Region: It provides regional market shares by production and revenue besides giving details about gross margin, price, and other factors related to the growth of regional markets studied in the report. The review period considered here is 2015-2019.

Company Profiles: Each player is assessed for its market growth in terms of different factors such as markets served, gross margin, price, revenue, production, product specification, and areas served.

Manufacturing Cost Analysis: It is sub-divided into four chapters, viz. industrial chain analysis, manufacturing process analysis, manufacturing cost structure, and key raw materials analysis.

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Stem Cell Therapy Market 2020 Key Players, Share, Trend, Segmentation and Forecast to 2026 - Cole of Duty

New Jersey, United States,- A new study was presented by Verified Market Research offering a complete analysis of the Stem Cell Therapy Market where the user can benefit from the complete market research report with all the useful information required on this market. This is a final report, covering the current impact of COVID-19 on the market. The coronavirus pandemic (COVID-19) has affected all aspects of life around the world. This has resulted in several changes in market conditions. The rapidly changing market scenario and the initial and future impact assessment are addressed in the report. The report examines all major aspects of the market with expert opinion on the current state of the market as well as historical data. This market report is a detailed study of growth, investment opportunities, market statistics, analysis of growing competition, key players, industry facts, important figures, sales, prices, revenues, gross margins, market shares, business strategies, main regions, demand and developments.

The Stem Cell Therapy Market Report provides a detailed analysis of the global market size, regional and national market size, segment growth, market share, competitive landscape, sales analysis, the impact of players in national and global markets, value chain optimization, business regulations, recent developments, opportunity analysis, strategic analysis of market growth, product launches and technological innovations.

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Major Players Covered in this Report are:

Stem Cell Therapy Market Segmentation

This market has been divided into types, applications and regions. The growth of each segment provides a precise calculation and forecast of sales by type and application, in terms of volume and value for the period between 2020 and 2026. This analysis can help you develop your business by targeting qualified niche markets. . Market share data are available at global and regional levels. The regions covered by the report are North America, Europe, Asia-Pacific, the Middle East and Africa and Latin America. Research analysts understand competitive forces and provide competitive analysis for each competitor separately.

By Types:

YYYY

By Applications:

ZZZZ

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Stem Cell Therapy Market Regions and Countries Level Analysis

The regional analysis is a very complete part of this report. This segmentation highlights Stem Cell Therapy sales at regional and national level. These data provide a detailed and precise analysis of the volume by country and an analysis of the market size by region of the world market.

The report provides an in-depth assessment of growth and other aspects of the market in key countries such as the United States, Canada, Mexico, Germany, France, the United Kingdom, Russia, the Italy, China, Japan, South Korea, India, Australia, Brazil and Saudi Arabia. The competitive landscape chapter of the global market report provides key information about market players such as company overview, total (financial) revenue, market potential, global presence, sales Stem Cell Therapy and the income generated, market share, prices, production sites and facilities, products offered and strategies adopted. This study provides Stem Cell Therapy sales, revenues and market shares for each actor covered in this report for a period between 2016 and 2020.

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Table of Contents

1. Executive Summary2. Assumptions and Acronyms Used3. Research Methodology4. Market Overview5. Global Market Analysis and Forecast, by Types6. Global Market Analysis and Forecast, by Applications7. Global Market Analysis and Forecast, by Regions8. North America Market Analysis and Forecast9. Latin America Market Analysis and Forecast10. Europe Market Analysis and Forecast11. Asia Pacific Market Analysis and Forecast12. Middle East & Africa Market Analysis and Forecast13. Competition Landscape

About us:

Verified Market Research is a leading Global Research and Consulting firm servicing over 5000+ customers. Verified Market Research provides advanced analytical research solutions while offering information enriched research studies. We offer insight into strategic and growth analyses, Data necessary to achieve corporate goals and critical revenue decisions.

Our 250 Analysts and SMEs offer a high level of expertise in data collection and governance use industrial techniques to collect and analyse data on more than 15,000 high impact and niche markets. Our analysts are trained to combine modern data collection techniques, superior research methodology, expertise and years of collective experience to produce informative and accurate research.

Contact us:

Mr. Edwyne Fernandes

US: +1 (650)-781-4080UK: +44 (203)-411-9686APAC: +91 (902)-863-5784US Toll Free: +1 (800)-7821768

Email: [emailprotected]

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Stem Cell Therapy Market Key Players, SWOT Analysis, Dynamics, Drivers, Key Indicators and Forecast to 2026 - Owned

Over the past few weeks, 23andMe and other genetic testing companies have made headlines for releasing candid statements acknowledging that their field and their products are too white. Its a problem with which geneticist Tshaka Cunningham is all too familiar.

As executive director of the nonprofit Faith Based Genetic Research Institute, Cunningham has traveled widely to speak at Black churches about the value of genetic research. And as co-founder and chief scientific officer of a genetics startup called TruGenomix, hes working to recruit more diverse cohorts to build a genetic test for gauging risk of developing PTSD.

Cunningham recently called in to STATs podcast, The Readout LOUD, to discuss genetics and racial inequity and what needs to be done to make the field actually reflect the worlds diversity.

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The transcript of the conversation has been lightly edited for clarity.

So, Tshaka, what do you make of the reckoning that weve seen in the past couple weeks from 23andMe and other genetics companies on these issues?

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You know, I think its actually a really good thing. I was glad to see it from the highest levels from these companies acknowledging an issue that many of us in the research community have known about for quite a long time, which is this lack of representation of diverse genomes in all of our studies and products. Im glad its starting to get deeper attention because I think it is a key issue thats going to impact the effectiveness of all of these tools over time.

Im looking forward to seeing some positive things that they will do to address it. So, you know, the first step is admitting you have a problem and then you go through the steps to rehabilitate. Im hoping that some positive things will come out of this.

What kinds of questions about genetics do you hear from the communities you speak with?

All kinds of questions. And first of all, I say, you know, the work that were doing with the Faith Based Genetic Research Institute is very unique in that we are bringing together individuals from the faith communities with scientists who are also people of color, and one of our guiding principles in the work that we do in the community is called the honest broker philosophy. That is, those of us who are imparting the information to the community are also from the community. And what we found is that it really helps us establish a better bond of trust for folks to be able to receive the information.

Some of the questions that we get when we talk about the value and the benefits of genetic research is the first questions are, you know, are they going to use it to hurt me? Thats the first question we get a lot from African American participants. And, you know, what will they do with the information? Theres a fair bit of distrust out there. And some of it is quite warranted from past transgressions of the medical establishment on the African American community. But once you sort of talk through those issues with folks and really kind of allow them to see some of the potential benefits, then you start getting a high level of interest.

So lets say 23andMe, for example, or one of the large companies, were to call you and ask for advice on what to do to make their products less Eurocentric and more inclusive. What would you tell them?

Start by making sure that your team, your executive team specifically, is representative of the community. A lot of companies sort of say, well, we cant find them. Any company needing to find a talented minority geneticist give me a call. Ive got a long list.

The second step would be to really use some of your resources to sponsor more research in this area. I mean, part of the challenge is also a financial and economic challenge. When you think about the economic disparities that have existed in America based on racial lines you know, the average African American has seven times less wealth than the average Caucasian. So they might not have even a hundred bucks to spend on something like genetic testing that could benefit them.

And then theres also the messaging. I think to the extent that these companies could help organizations like ours, the Faith Based Genetic Research Institute, other academic institutions, with messaging about the importance or the potential benefits of this, that would be great.

Now, I know thats a fine line that they have to walk because, you know, you dont want to seem coercive. But at the same time, I think trying to really do authentic outreach to the community would start with having more of your employees be from the community and then having a dedicated effort of that kind of outreach within your operation.

One of the more controversial questions in this conversation is around compensation. So what do you think? Do you think that 23andMe should pay people in the Black community and other underrepresented populations for their data?

I believe anybody that contributes their data should have the opportunity to get paid for it if its used. I do not believe in coercing someone to contribute their data with payment. But if Im an individual who has contributed and then you go and use my my data lets say a pharma company buys access to my data and I dont see any benefit from it, then that feels a bit un-American and I just dont feel like its fair. But thats my personal opinion.

So lets talk a little bit about polygenic risk score tests, which really encapsulate the diversity problems in genetics. So, for readers who are unfamiliar with them, these are tests that gather multiple genetic variants together and use them to predict someones chances of developing a disease. So far, many commercial polygenic risk score tests have come off warnings that theyre not very accurate or are even useless in people who are not of European ancestry. But your startup, TruGenomix, is working on a polygenic risk score test to try to gauge risk for developing PTSD. And youre trying to build the test using more diverse data. Tell us about your approach.

Ive recognized the importance of diversity in your datasets. From my earliest days, when I was at the Department of Veterans Affairs, we had a large genomics project called the Million Veteran Program. And part of my contribution to that project was to make sure that minority veterans participated. And so we actually went to great effort to ensure that. And that project has done very well to the credit of the VA, to recruit minority veterans. So that data set is going to provide some rich understanding, or has that potential to provide rich understanding, in polygenic risk for minority communities.

I took some of what I learned there from having to really take the time to do the outreach to the communities, to make sure that the end products are representative. I think that is just core to our actual DNA as a company. I think part of that has to do with the fact that were one of the very few minority-owned genomics companies in the country right now. This was top of mind for us. We wanted to make sure that whatever products we were putting out, the polygenic risk related to all communities, specifically the African American community, which my founders and I come from. It was just a very important thing for us to do not only for societal and ethical reasons, but also for scientific integrity reasons, because as a scientist, I dont believe in putting out products that arent probably applicable to all communities.

So why havent other makers of polygenic risk score tests taken this more holistic approach?

You know, I cant speak for them. I mean, I dont know. Thats a question that I have. I would hope that they take a deeper look at it. Maybe their market calculations were, OK, the people using genetic tests now tend not to be people of color. And therefore, we dont need to care about them. I dont know. Youll have to ask them that question.

All I could say is that I hope that all of the companies that are making these kinds of tests really take diversity seriously. Ive given lectures around diversity and genetics in the past. The majority of the DNA in the world is not of Caucasian origin. Its actually of Asian origin. And then African and Latino. And then Caucasians are only maybe about 14% of all the DNA out there just based on population. So when you think about it in that respect, if you really want to have a genome that is globally applicable, then youd really need to focus on its diversity.

Tshaka, thank you for coming on the podcast today.

Great. Its great being with you all today.

Theresa Gaffney contributed to this report.

This is a lightly edited transcript from arecent episodeof STATs biotech podcast, The Readout LOUD. Like it?Consider subscribing to hear every episode.

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A geneticist advocates for diversity and fixing his industry in the process - STAT

Can a vaccine be an October surprise? Are journal publishers running a racket? And why is genetics so white?

We discuss all that and more this week on The Readout LOUD, STATs biotech podcast. First, we run through a busy week in news, discussing the results of a major study on Covid-19 treatment, an escalating fight in the publishing world, and the drug industrys biggest-ever IPO. Then, physician and health care policy expert Ezekiel Emanuel joins us to discuss his nightmare scenario: President Trump, desperate for re-election, forces the approval of an ineffective coronavirus vaccine. Finally, we talk to geneticist Tshaka Cunningham about the deep racial inequities in the field of genomics and what can be done to correct them.

For more on what we cover, heres the news on a potential Covid-19 treatment; heres more on the the fight over academic publishing; heres a look at inequality in genetics; and heres the latest in STATs coronavirus coverage.

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Well be back next Thursday evening and every Thursday evening so be sure to sign up onApple Podcasts,Stitcher,Google Play, or wherever you get your podcasts.

And if you have any feedback for us topics to cover, guests to invite, vocal tics to cease you can emailreadoutloud@statnews.com.

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Listen: The latest on Covid-19, vaccine politics, and diversifying genetics - STAT

The impetus for the campaign can be traced back to a crime spree in the northern Chinese region of Inner Mongolia. For nearly three decades, the police there investigated the rapes and murders of 11 women and girls, one as young as 8. They collected 230,000 fingerprints and sifted through more than 100,000 DNA samples. They offered a $28,000 reward.

Then, in 2016, they arrested a man on unrelated bribery charges, according to the state news media. Analyzing his genes, they found he was related to a person who had left his DNA at the site of the 2005 killing of one of the women. That person, Gao Chengyong, confessed to the crimes and was later executed.

Mr. Gaos capture spurred the state media to call for the creation of a national database of male DNA. The police in Henan Province showed it was possible, after amassing samples from 5.3 million men, or roughly 10 percent of the provinces male population, between 2014 and 2016. In November 2017, the Ministry of Public Security, which controls the police, unveiled plans for a national database.

China already holds the worlds largest trove of genetic material, totaling 80 million profiles, according to state media. But earlier DNA gathering efforts were often more focused. Officials targeted criminal suspects or groups they considered potentially destabilizing, like migrant workers in certain neighborhoods. The police have also gathered DNA from ethnic minority groups like the Uighurs as a way to tighten the Communist Partys control over them.

The effort to compile a national male database broadens those efforts, said Emile Dirks, an author of the report from the Australian institute and a Ph.D. candidate in the department of political science at the University of Toronto. We are seeing the expansion of those models to the rest of China in an aggressive way that I dont think weve seen before, Mr. Dirks said.

In the report released by the Australian institute, it estimated that the authorities aimed to collect DNA samples from 35 million to 70 million men and boys, or roughly 5 percent to 10 percent of Chinas male population. They do not need to sample every male, because one persons DNA sample can unlock the genetic identity of male relatives.

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China Is Collecting DNA From Tens of Millions of Men and Boys, Using U.S. Equipment - The New York Times

Keith McArthur is the CEO of CureGRIN Foundation and creator and host of Unlocking Brysons Brain.

Around Fathers Day in 2018, scientists told me the unthinkable that it might be possible to cure my son Brysons rare genetic disease.

Bryson has GRIN Disorder, caused by a mutation in his GRIN1 gene that prevents him from walking or talking or feeding himself. Even though hes 13, his brain functions at the cognitive level of a toddler, according to a recent report from a developmental psychologist.

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So when researchers told us his symptoms might some day be reversed, I dedicated my life to connecting scientists and pushing for a cure.

But the more I learn, the more I struggle with an important ethical question: Is it ableist to want to cure my son?

Cure is a loaded term. For parents of kids with rare diseases, its a no-brainer. Of course, we should want to give our kids the life they were supposed to have. Of course, we should want to help them.

But for many people living with disabilities, cure implies theres something wrong with them, something that needs fixing. And some people who rely on wheelchairs say that even if there were a cure that could allow them to walk, they wouldnt want it.

As Brysons dad, Ive always thought of myself as an advocate for disability rights. I proudly stood up to the local school board to argue people with special needs deserve more of a say about where they go to high school. Ive leveraged my privilege to complain about broken elevators and insufficient handicapped parking.

And it felt like my efforts to bring together researchers and push for a cure was the ultimate act of advocacy for my son and others like him.

But the other day, someone I dont know called me ableist.

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The accusation came in a negative review for Unlocking Brysons Brain, a podcast series about my son. The reviewer identified as someone with a lifelong physical disability and said my familys obsession with getting a cure made them feel uneasy and uncomfortable.

Im sorry, but this guys is not a disability advocate. Hes an ableist who is obsessed with transformation, the reviewer wrote.

The podcast has elicited positive feedback from many other people with disabilities; so Im wary of overreacting to one negative review. But as much as I want to push back and say, Thats not who I am, theres part of me that wonders whether theres truth in that review.

Am I obsessed with cure? Maybe I am. In addition to my search for a cure for Bryson, and my podcast about this search, Im also chief executive of CureGRIN, an organization focused on finding a cure for GRIN Disorder.

Even my Twitter bio identifies me as a rare disease dad searching for a cure. So yes, Ive internalized this search for a cure and made it part of my personal identity.

But does that mean its wrong?

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It doesnt feel wrong. After all, I worry that Bryson cant communicate his wants and desires, that he cant pilot his own wheelchair, that he cant defend himself from those who might want to do him harm. Im worried about his violent episodes when he flails around until hes covered in bruises and bites himself so hard were worried hell tear an artery. Im terrified about whats going to happen to Bryson when his mother and I arent around to look after him. Dont I owe it to Bryson to push for medicines that can give him more agency and security?

But how much cure is too much? Is it moral to push for safety and autonomy, but ableist to wish for a cure that could make Bryson neurotypical?

Because if Im being honest, thats what I want. If there were a magic pill that could make Bryson fully neurotypical, I would give it to him. I want him to be able to walk on his own, and feed himself, and tell me what his life has been like for the past 13 years. And when hes grown up, I want him to be able to live independently, and have a job, and get married and have kids.

Bryson is perfect; hes extraordinary. But I want more than that. I want him to be able to choose to be ordinary.

The trouble is that Bryson cant choose. Yes, hell sometimes make simple choices, for example by reaching to indicate if he wants pudding or applesauce as a snack.

But when I ask him whether he wants me to continue on with this journey to find him a cure, he just looks back at me with his big beautiful eyes.

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So even though I understand that cure is an ethical quagmire, I feel compelled to carry on.

The question is how to push for a cure for Bryson without making others living with disabilities feel uneasy and uncomfortable.

As part of my journey, Ive spoken with ethicists and activists with disabilities about the concept of cure and how to make sure I pursue my quest in an ethical way.

Part of the solution is to make sure Im giving Bryson as much of a voice as possible. Even if he cant answer complex questions around a cure yet, its important that Im always asking myself: What would Bryson want? And is it different from what I want for him? And if there are partial therapies in the future that could allow Bryson to communicate, I need to be willing to listen to what he has to say about this journey for a cure.

Its also critical that I recognize that a cure for Bryson may never come. And even if there are therapies that can make a radical difference in his life, therapies that can provide safety and agency, they are not likely to make Bryson neurotypical. Bryson is likely to live out the rest of his life as someone with high needs.

And thats okay. Because Bryson is already perfect. Its the world that isnt.

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So if the anonymous reviewer is right, if I really am obsessed with transformation, then I need to redirect some of that obsession away from changing my son and toward changing the world. Because thats another way I can help him to be safer and have more autonomy by working to dismantle the barriers, both physical and systemic, faced by all people living with disabilities.

Finally, its critical that I continue to cherish Bryson for who he is today, a vibrant teenager who knows joy and sadness, an extrovert who loves being around people, a loving soul who wraps his arms around his dad and pulls me close, showering me with wet toothy kisses. How many fathers of able-bodied kids will get such a wonderful gift from their teenage sons this Fathers Day?

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I want to cure my son of his rare genetic disease. Is that wrong? - The Globe and Mail