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Guaranteed Ingredient in Any Coronavirus Vaccine? Thousands of Volunteers – The New York Times

June 14th, 2020 7:52 am

Thats the beauty of these DNA vaccines, said Wolfgang W. Leitner, the chief of the innate immunity section at the National Institute of Allergy and Infectious Diseases. They are simple and fast in terms of development.

Nor are vaccine scientists concerned about the supposed secret sauce. In fact, its quite the opposite: They are skeptical precisely because the technology behind DNA vaccines has been around for decades and has been applied toward so many infectious diseases H.I.V., the flu, malaria yet none of the vaccines have made it to market.

They believe that this approach is capable of producing immunity. Already, DNA vaccines have been licensed for use in pigs, dogs and poultry. But the big if, according to Dr. Dennis M. Klinman, a vaccine scientist who worked at the Food and Drug Administration for 18 years, is whether one will ever be able to generate strong enough an immune response in humans.

Even though Ms. Wiley had read the packet on the science of it all, the next step felt like entering uncharted territory.

Shortly after the initial injection, a nurse handed Dr. Ervin a device resembling an electric toothbrush. He pressed the head which contains three tiny needles instead of bristles over the raised skin on her arm, where shed just had a shot. Then he zapped her.

It was not painful, but its unlike anything Ive ever experienced, Ms. Wiley said.

The carefully calibrated electrical pulses basically steer the DNA into the cells by briefly opening up pores in their membrane, according to David B. Weiner, the director of the vaccine and immunotherapy center at the Wistar Institute and an adviser to Inovio.

Although it may sound fantastical, the technology, called electroporation, dates to the 1980s, when a similar approach was first used to make transgenic plants, according to Dr. Leitner.

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Why one-size-fits-all diets don’t work new study – The Conversation UK

June 14th, 2020 7:52 am

The coronavirus pandemic has pushed health to the forefront of many peoples minds. And while the best way to avoid COVID-19 is not to catch the virus in the first place, were starting to understand why some people become seriously ill with the disease while others have only mild or no symptoms.

Age and frailty are the most important risk factors for severe COVID-19, but data from our COVID Symptom Study app, used by nearly four million people, has shown that diet-related conditions, such as obesity, heart disease and type 2 diabetes, are significant risk factors for ending up in hospital with the disease.

In the UK, around one in three adults are obese and many more are overweight. In the US, around two in five adults and nearly one in five children are obese. From generalised government nutritional guidelines to Instagram-worthy fad diets, theres no end of advice on how to lose weight. Clearly, it isnt working.

This is a complex problem to unpick. Factors such as sex, ethnicity, socioeconomic status and availability of healthy food all play a part. But on an individual level, we still understand relatively little about how each person should eat to optimise their health and weight.

In search of answers, our research team at Kings College London together with our colleagues at Massachusetts General Hospital, Stanford University and health science company ZOE launched PREDICT, the largest ongoing nutritional study of its kind in the world. Our first results have now been published in Nature Medicine.

PREDICT-1, the first phase of the PREDICT research programme, involved more than 1,000 adults (including hundreds of pairs of twins) who were continuously monitored for two weeks to discover how they respond to different foods.

Participants had an initial set-up day in hospital for detailed blood measurements and testing of responses after eating carefully designed set meals. They then carried out the rest of the study at home, following a schedule of set meals and their own free choice of foods. We measured a wide range of markers of nutritional responses and health from blood glucose, fat, insulin and inflammation levels to exercise, sleep and gut bacteria (microbiome) diversity.

This kind of detailed, ongoing analysis was made possible through the use of wearable technologies. These included continuous blood glucose monitors and digital activity trackers, which meant we could keep track of our participants blood sugar and activity levels 24/7. Simple finger-prick blood tests also allowed us to measure their blood fat levels on a regular basis.

All these measurements added up to millions of datapoints, which needed to be analysed with sophisticated machine learning techniques (a type of artificial intelligence) in order to spot patterns and make predictions.

The first thing we noticed was the wide variation in individual insulin, blood sugar and blood fat responses to the same meals, even for identical twins. For example, one twin might have healthy responses to eating carbohydrates but not fat, while the other twin is the opposite. Straight away, this tells us that we are all unique and that there is no perfect diet or correct way to eat that will work for everyone.

The observation that genetics only plays a minor role in determining how we respond to food also tells us that simple genetic tests claiming to determine the right diet for your genes are ineffective and misleading. Curiously, identical twins only shared around a third of the same gut microbe species, which may help to explain some of the variation in nutritional responses and also points towards an opportunity to improve health and weight by manipulating the microbiome.

We also discovered that the timing of meals affects nutritional responses in a personalised way. The same meal at breakfast caused a different nutritional response in some people when eaten for lunch. But in other people there was no difference, busting the myth that there are correct mealtimes that will work for all.

Another surprise was finding that the composition of meals in terms of calories, fat, carbohydrates, proteins and fibre (macronutrients or macros) also had a highly individualised effect on nutritional responses. Some people handle carbs better than fat, for example, while others have the opposite response. So prescriptive diets based on fixed calorie counts or macronutrient ratios are too simplistic and will not work for everyone.

However, despite the wide variability between participants, each persons own responses to identical meals eaten at the same times on different days were remarkably consistent. This makes it possible to predict how someone might respond to any food based on knowledge of their underlying metabolism.

Intriguingly, we found that the levels of inflammatory molecules in the blood varied by up to tenfold, even in seemingly healthy people, and that a rise in these inflammation markers was linked to having unhealthy responses to fat.

We use the term dietary inflammation to refer to these unhealthy metabolic effects that are triggered after eating. Repeatedly experiencing dietary inflammation brought on by excessive blood sugar and fat responses is linked with an increased risk of conditions such as heart disease, type 2 diabetes, non-alcoholic fatty liver disease and obesity.

On a more positive note, our findings suggest that it might be possible to improve weight management and long-term health by eating in a more personalised way designed to avoid triggering unhealthy inflammatory responses after meals.

When it comes to weight, weve traditionally put a huge emphasis on factors we have no control over, especially genetics. The fact is, while genetics plays a role, many more important factors affect how our metabolism, weight and health. Its time to move away from overly generalised guidelines, fad diets and one-size-fits-all plans and develop more personalised, scientific approaches to nutrition that understand and work together with our bodies, not against them.

For more on personalised nutrition, download and listen to our podcast, Medicine made for you, a series by The Anthill.

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Choose best time to claim benefits – GREAT BEND TRIBUNE – Great Bend Tribune

June 14th, 2020 7:50 am

Dear Rusty: We served overseas for several years, not earning many quarters for Social Security. However, we have made sure that we paid in over time so we can receive a benefit, but it will not amount to much. For the past several years now, we have been back in the U.S., earning some professional salaries. Now it looks like at full retirement age my husband will get $1,147 per month, and I will get $1,026 per month. I was born in 1957 and my husband in 1956.

Question #1: For the most financial benefit, when should we each start collecting SS (either now or at full retirement age)? And question #2: Will our amounts change because we are married and both collecting? Signed: Overseas Worker

Dear Overseas Worker: To answer your second question first, no, your benefit amounts will not change because you are married and both collecting. Based upon the numbers you provided, neither of you will be eligible for a spousal boost from the other because your benefit amounts at your full retirement age (FRA) are too similar, so maximizing your individual benefits should be your goal.

As for your other question, when you should start collecting depends upon a number of factors, including your financial needs and, importantly, your expected longevity. Both of you can get the maximum benefit available to you by waiting until you are 70 years old to claim, but that only makes sense if you are in good health and expect at least average longevity (about 84 for a man and 87 for a woman).

If you claim benefits before you reach your full retirement age (66 for you and 66 plus 4 months for your husband), those benefits will be cut. If you collect now, your benefit would be cut by about 27% and your husbands by about 22% (based upon your respective years of birth). Further, if you claim before your full retirement ages and continue to work, youll be subject to Social Securitys earnings test, which limits the amount you can earn before they take back some of your benefits (the 2020 earnings limit is $18,240; if you exceed that theyll take back half of anything you earn over the limit). The earnings limit changes annually but goes away at your FRA.

At your full retirement ages, youll be entitled to 100% of the benefits youve earned from your lifetime of working (approximately the amounts estimated now). If you can and do wait beyond your FRA, for each month you delay youll earn delayed retirement credits of 2/3 of 1% per month of delay (8% per year of delay), up to age 70 when your maximum benefit is reached. As a point of information, if you wait until your full retirement age to claim, you will have collected the same amount of money at age 78 as if you had claimed at age 62; and if you wait until age 70 to claim youll have collected the same amount of money at age 82 as if you had collected at your full retirement age. If you live at least until average longevity, youll collect more in cumulative Social Security benefits by waiting.

So, when should you claim? If youre still working and earning professional salaries, then waiting at least until your full retirement age would be a wise choice. If you expect at least average longevity and dont need the money right away, waiting until age 70 would be a prudent strategy. But if you dont work and expect less than average longevity, then claiming at any time you need the money would be a reasonable decision. This is a choice only each of you can make.

Russell Gloor is an Association of Mature American Citizens certified social security advisor. To submit a question, visitamacfoundation.org/programs/social-security-advisory or email ssadvisor@amacfoundation.org

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Freeze Dried Dog Food for Health and Longevity – iHeartDogs.com

June 14th, 2020 7:50 am

When it comes to dog food, we all want to make sure we are feeding our dogs all the goodness they need without any harmful ingredients or additives. I am one of those dog moms. Thats why I jumped at the opportunity to try Dr. Jeffs Optimum freeze-dried dog food and Daily Canine Care supplement. My dog was so excited after eating this food that she celebrated with some zoomies!

I adopted my female Hound Mix from Homeward Bound Animal Welfare Group in 2018. She is two years old and weighs 35 pounds. She currently has a healthy body shape, but I have to be careful about portion size with her. She is a bit on the short side and quickly becomes rotund if overfed. She currently eats a mix of a limited ingredient dry dog food topped with fresh fruit or veggies and homemade meals of meat or fish, whole grains, and veggies. Townes gets regular exercise on our daily 2-3 mile walks.

I grew up with a family dog and have had dogs of my own throughout my adulthood. Like many of us, I always fed my dogs a dry food that was convenient and affordable without giving much thought to ingredients or processing. That has changed. As I got older and became more aware of nutrition and its impact on my own health, I realized that I needed to have the same concerns for my dogs.

My dogs experienced health issues that I believe were directly tied to the food they ate. Terrible skin allergies plagued my adopted Black Lab Mix, Morgan. Then I lost my sidekick Murphy to cancer. I want Townes to live the longest, healthiest life possible. The food she eats plays an incredibly important role in that.

In a landmark five year study of over 500 dogs, researchers Bruno Sapy and Dr. Gerard Lippert concluded that a dogs diet is one of the most significant contributors to longevity. In fact, their research showed that dogs who eat homemade meals made from whole foods lived an average of 32 months longer than those who ate commercial dog food. That is almost three years! Dr. Jeffs Optimum and Daily Canine Care supplements are well-balanced, affordable, and nutritionally advanced. They offer you the convenience of kibble with the benefits of homemade, contributing to happiness, a lower risk of disease and obesity, and a longer life.

Dr. Jeff is a nationally renowned veterinarian and pet journalist. For over 35 years, he has been practicing veterinary medicine in Los Angeles. He is known as the Celebrity Vet for treating dogs whose humans have celebrity status. Dr. Jeff was drawn to veterinary medicine because of his love for animals. That love is the driving force behind Dr. Jeffs freeze-dried dog food and supplement. He and his team of dog lovers have developed a well-balanced, affordable, nutritionally advanced food, and probiotic supplement that helps dogs live longer, healthier, happier lives.

Freeze-drying is the most nutritionally sound way to preserve food. Freeze-dried foods are the same size and shape as the original food. They do not require refrigeration and are shelf-stable for long periods of time. When you place freeze-dried foods in water, they reconstitute, returning to their original form. According to industry leader Freeze-Dry Foods, freeze-dried foods maintain nutrients, color, flavor, and texture often indistinguishable from the original product. Dr. Jeffs freeze-dried dog food allows you to serve your dog the nutritional equivalent of homemade fresh foods without the fuss.

The ingredients in Dr. Jeffs Optimum are simple, limited, and real. Beef, turkey, and duck are the first ingredients in this 32% protein food for dogs. Optimum also includes two different types of organ meat and two different types of seafood. Actual fruit and vegetables and specially selected additives like turmeric, folic acid, and kelp make this formula uniquely designed for health and wellness. The ingredients are not just wholesome; they are evolutionary.

Optimum was designed by experts who understand what a dog should be eating. Dog moms and dads can feel secure knowing their dog will get all the energy-lifting and disease-fighting ingredients they need with Optimum. They can also feel confident that Optimum is free of artificial flavors, colors, synthetic preservatives, and biologically unsound fillers like corn, soy, and wheat.

When changing to Optimum, you should phase it in over the course of a week. This is done to avoid digestive upset for your dog. A handy schedule is included in the package that Dr. Jeffs ships for free. When I opened the package, my dog recognized right away that something special was about to be served up. I added water per the instructions and watched as the nuggets rehydrated and released a dog-pleasing aroma of meat.

I could barely get the bowl down before she gobbled it up and licked the bowl. Afterward, she was positively bursting with energy and showed me how happy she was with an athletic zoom around the yard. I like to mix things up for her at meals, offering her a variety of tastes and textures. One of the things that I like best about Dr. Jeffs Optimum is that it can be used as the primary meal or as a topper to change things up.

One of the easiest ways to support well being is through probiotic supplementation. This is true for humans and dogs! Probiotics support healthy digestion, nutrient absorption, and the bodys immune system. Dr. Jeffs Canine Care gives your dogs an unprecedented ten different strains of probiotics along with three super ingredients.

When I first used Dr. Jeffs Canine Care, Townes nose let her know that something delicious was being sprinkled on her food. This supplement is infused with bacon flavor, and we all know that dogs dig bacon. It was helpful to mix in into the other food with a bit of water, which spread the pleasant taste over the entire dish and ensured that she would ingest all of the dissolved powder.

I look forward to seeing how this supplement will help her maintain a healthy weight and body shape. She also has pretty severe anxiety in the car. Research has pointed to a reduction in anxious behaviors in canines through probiotic supplementation. Using this potent 10-strain formula may be just the supplement she needs to feel calm and relaxed on necessary car rides.

The dog lovers at Dr. Jeffs are so confident that you will love their food for dogs that they always offer an unconditional 60-day money-back guarantee. If you or your dog are not over the moon with the results you get from Optimum, they will gladly refund every cent of your order, without questions. However, there is something even better being offered to the iHeartDogs community. For a limited time, you can get a bag of Optimum for free! Dont wait. Try Dr. Jeffs Optimum today!

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Aon warns against over-reaction to short-term COVID-19 mortality data – Reinsurance News

June 14th, 2020 7:50 am

Global reinsurance broker Aon says longevity markets are continuing to function effectively despite COVID-19 and has cautioned pension schemes against over-reacting to high short-term UK mortality data when setting their long-term mortality assumptions.

Tim Gordon, partner and head of Demographic Horizons in Aons Risk Settlement Group, noted how were emerging from the initial wave of the global COVID-19 pandemic with no effective vaccine and with some critical aspects still unknown. As a result, some people assume that life expectancy must have reduced, but this is not necessarily the case.

While there are potential outcomes of this crisis that could reduce life expectancy, including the possible impact of economic recession, there are also potential outcomes that could result in higher life expectancy, said Gordon.

These could include increased spending on health and social care, and a potential hardening of the UK to future pandemics.

On top of this, the socio-economic profile of pension schemes means that their liabilities are typically partially insulated from the variations we see in national mortality statistics.

Accordingly, it would be premature now to make major changes to best estimate longevity assumptions in either direction. Indeed, it is reasonable for median best estimate assumptions to remain broadly unchanged.

Martin Bird, senior partner and head of Aons Risk Settlement Group, added, Longevity markets have continued to function efficiently over the course of the crisis to date, with bulk annuities and longevity swap transactions continuing apace.

Trustees and sponsors have, in our experience, taken the view that risk settlement forms part of their long-term risk management strategy and have been comfortable with proceeding with transactions, despite the turbulence from COVID-19.

In fact, in some cases, agile clients have been able to take advantage of pricing opportunities, such as those arising from increased credit spreads earlier in the crisis.

More than ever, it is important for schemes to keep their wits about them when entering a potential transaction.

Particular features in the current environment are the need to understand the consequences of different on-risk dates and the potential for regret risk as well as ensuring that investment portfolios are adequately stress-tested to guard against any later liquidity problems.

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JPMorgan: Bitcoin’s Market Structure More Resilient Than Currencies, Equities, Treasuries and Gold | News – Bitcoin News

June 14th, 2020 7:49 am

JPMorgans strategists have reportedly found bitcoins market structure to be more resilient than those of currencies, equities, Treasuries, and gold. In a new report on bitcoins stress test, JPMorgan wrote that cryptocurrencies have longevity as an asset class.

In a new report entitled Cryptocurrency takes its first stress test: Digital gold, pyrite, or something in between? JPMorgans strategists say bitcoin is looking mostly positive, Bloomberg reported Friday. The report, led by head of U.S. interest rate derivatives strategy Joshua Younger and cross-asset research analyst Nikolaos Panigirtzoglou, shows that cryptocurrencies have longevity as an asset class.

The report examines bitcoin, cryptocurrencies, and other financial assets as they plunged in March when the coronavirus pandemic exploded in the U.S., causing shutdowns that crippled the economy. While bitcoin crashed to under $4,000, it bounced back faster than most other assets and recouped most of its value by the end of April. Moreover, bitcoins valuations did not diverge much from intrinsic levels during the March panic. Though the bubble collapsed as dramatically as it inflated, the strategists wrote:

Bitcoin has rarely traded below the cost of production, including the very disorderly conditions that prevailed in March.

The JPMorgan strategists also found that the cryptocurrencys price action points to their continued use more as a vehicle for speculation than medium of exchange or store of value, noting that bitcoin appears to have been correlated to riskier assets like equities.

Furthermore, the report describes that there were few signs of a flight to liquidity within the asset class, as most cryptocurrencies collectively fell in March. Concluding that bitcoin weathered its stress test well, the strategists wrote: there is little evidence of run dynamics, or even material quality tiering among cryptocurrencies, even during the throws of the crisis in March.

The report also explores liquidity, or the bid-offer spread of the order book, which is directly related to volatility. When the order book thins, a given transaction could result in a larger price change, and vice versa, the news outlet conveyed. Though bitcoin saw among the most severe drops in liquidity around the peak of the crisis, that disruption unwound itself much faster than other asset classes. According to the publication, the strategists wrote:

The coins market structure turned out to be more resilient than those of currencies, equities, Treasuries and gold.

JPMorgan has come a long way in its recognition of bitcoin. In September 2017, CEO Jamie Dimon called bitcoin a fraud, only to regret saying it a few months later. Now JPMorgan Chase is even providing banking services to bitcoin exchanges: Coinbase and Gemini. Last month, the company agreed to pay $2.5 million to settle a class-action lawsuit for overcharging fees for crypto transactions.

What do you think about JPMorgan changing its views on bitcoin? Let us know in the comments section below.

Image Credits: Shutterstock, Pixabay, Wiki Commons

Disclaimer: This article is for informational purposes only. It is not a direct offer or solicitation of an offer to buy or sell, or a recommendation or endorsement of any products, services, or companies. Bitcoin.com does not provide investment, tax, legal, or accounting advice. Neither the company nor the author is responsible, directly or indirectly, for any damage or loss caused or alleged to be caused by or in connection with the use of or reliance on any content, goods or services mentioned in this article.

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COVID-19 and the link between religious practices and personal health – Deseret News

June 14th, 2020 7:49 am

SALT LAKE CITY In April, a Virginia pastor died from the coronavirus after telling his congregation to ignore physical distancing rules. Even after the story made national news, some religious leaders continued to defy public health orders and hold services, including a Louisiana pastor who told his church members, God gave you an immune system to kill that virus.

The next month, the Centers for Disease Control and Prevention warned the virus can spread easily at large religious gatherings, citing a case where two people with COVID-19 infected 35 others in March at church events in Arkansas.

Stories like these show the potential danger of holding large meetings while the coronavirus continues to claim U.S. lives and could cast religious leaders who insist on public worship in a negative light. But Harold G. Koenig, professor of psychiatry and director of the Center for Spirituality, Theology and Health at Duke University Medical Center, has some positive news for people of faith. He argues that religiousness may actually reduce a persons risk of contracting and dying from COVID-19.

According to Koenig, people who participate in organized religion or have their own spiritual practices are less likely to engage in unhealthy behaviors like smoking and drinking and more likely to have good habits like eating well and exercising. Not only can religious and spiritual involvement impact peoples physical health via their lifestyle choices, but it can also have a significant effect on their emotional well-being, said Koenig. All these factors combined can give a persons immune system a leg-up in fighting off viruses of any kind, he said.

Theres no question religion has an impact on both susceptibility to viral infections and recovery from it once youre infected, said Koenig, who was raised Catholic and now practices in a Protestant church. This just makes sense when you think about it.

However, Nicole Fisher, president of Health & Human Rights Strategies, a health care and human rights-focused advising firm in Washington, D.C., warns that religion and spirituality are not protective measures against COVID-19 on their own.

Viruses dont have any respect for religion, race, gender, politics or anything else. They look for a suitable host, and that can be anyone not taking proper precautions, said Fisher, who is spiritual but does not associate with a particular religion.

Still, there are clear links between beliefs, emotions and the body, Fisher said.

Prayer alone cannot cure you, Fisher said. But, with medical attention appropriate for how bad your illness is, prayer, meditation and faith can certainly bring a person peace of mind which can undoubtedly improve mental and emotional health, which is oftentimes linked to physical health.

More than a hundred studies have found that religious people are less likely to smoke, a habit which has a large impact on coronavirus outcomes.

According to Stanton Glantz, a professor of medicine and director of the University of California, San Franciscos Center for Tobacco Control Research and Education, research shows smoking nearly doubles a persons risk of COVID-19 disease progression, which could involve the need for critical care or death.

Glantz explained that the respiratory system has a very strong natural immune function, starting with microscopic hairs called cilia in the nose that trap viruses, bacteria and toxins. Deeper inside the lungs, cells called macrophages gobble up those things that can harm the body.

Smoking disables a lot of that immune function and makes you more susceptible to getting infected. Then if you get infected, the infections are worse, said Glantz, who added that vaping has a lot of the same effects as smoking.

According to Koenig, most research involving religion and health looks at Christianity, which promotes healthy behaviors by teaching that the body is a temple. But there are a number of studies that also examine Islam, Judaism, Buddhism and Hinduism, which all espouse similar beliefs about the sanctity of the body. Vegetarianism and yoga practices associated with Hinduism and mindfulness and breathing practices associated with Buddhism can also have direct health benefits, Koenig said.

A 2017 study by researchers from the Emory Rollins School of Public Health categorized subjects as Protestant, Catholic, Jewish, other religion or no religion. The study demonstrated a link between regular attendance at religious services with improved health and lowered mortality. They found that people who attended services frequently had a 40% lower hazard of mortality compared with those who never attended. Even those who attended services less frequently had a greater protection against mortality than those who didnt attend at all, but there were no differences by religious affiliation.

Stress increases susceptibility to viral infections, said Koenig, but individual spiritual practices and the support networks that come with organized religion can promote emotional well-being.

A big part of going to church is the social support in the community that one receives, said Carolyn Aldwin, director of the Center for Healthy Aging Research at Oregon State University. Social integration has a big effect on health outcomes.

Aldwin was raised Catholic and now attends an Episcopal church. To protect against the coronavirus, religious communities can support people who are older or immunocompromised by calling and checking in on them, or providing services like grocery shopping so they can avoid going out, Aldwin said.

The benefits of emotional self-regulation are also significant, said Aldwin, who has studied the effects of religion and spirituality on people with congestive heart failure.

When you have something like congestive heart failure, which is very hard to regulate and difficult to live with, being calmer and happier, and maybe feeling supported may allow you to experience less distress and even live longer, Aldwin said.

According to Koenig, positive emotions have the opposite effect on the immune system that negative emotions and stress have.

If you have meaning and purpose, if you have joy and satisfaction with life, if you experience a sense of peace, all of that has a positive impact on the immune system in the exact opposite way seen with chronic stress, anxiety and depression, Koenig said.

Cardiologist Dhanunjaya Lakkireddy, medical director of the Kansas City Heart Rhythm Institute, has set out to test the health impacts of one particular spiritual practice: prayer.

Lakkireddys COVID prayer study is set up as a double-blind randomized control trial, where coronavirus patients who voluntarily enroll on the website will be assigned into either a control group, or a group that will be prayed for by various volunteer religious groups representing the Christian, Muslim, Hindu, Jewish and Buddhist traditions. Lakkireddy and his colleagues plan to measure whether this remote intercessory prayer affects coronavirus outcomes like mortality, number of days in the ICU and days on a ventilator.

Lakkireddy was born into Hinduism and went to a Catholic school, but doesnt consider himself to belong to one religion in particular. He said the study required hardly any funding from the institute because he and others have all volunteered their time.

I was always intrigued by this idea of a supernatural divine power that can impact what we do as human beings on this earth, said Lakkireddy. As scientific and critical as I want to be in my thinking, the question about this divine force interested me.

But Aldwin is skeptical that any one aspect of spirituality, like prayer will prove to have a large impact on health with the coronavirus.

People who are sincerely religious have multiple things going for them, its the community which provides support, almost like a social safety net. Theres the better health behaviors, the calmness and acceptance in the face of adversity, said Aldwin. Its the whole package.

While some religious practices and belief systems may be correlated with healthy behaviors, the benefits could be instantly negated if people of faith are gathering to worship in large groups without the proper precautions, like social distancing and wearing masks. Multiple coronavirus outbreaks have been traced to religious groups, like Orthodox Jewish communities in New York or the Shincheonji religion in South Korea.

Religiousness, spirituality or faith, as in all facets of life and current health challenges, can be part of the problem or part of the solution, said Jeff Levin, University Professor of epidemiology and population health and director of the program on religion and population health at Baylor University. Where there are messages coming from the pulpit, or coming from religious leaders, telling people to ignore public health messages, I just think its incredibly foolish.

With coronavirus fatalities decreasing by the week across the country, U.S. churches are beginning to open back up. But most are trying to discourage the hugging and hand-shaking that typically accompanies fellowshipping. Some are implementing rules regarding how close people can sit in the pews, or eliminating the tradition of singing hymns because exhaling air with increased force can spread the virus farther.

Levin, who is Jewish, said he thinks these precautions are reasonable and wise.

Churches and pastors and religious organizations shouldnt be a source of anxiety for people, or discouragement, they should be supporting people and letting people know we will get through this, just a little longer, said Levin. We dont want to undo the good that weve done. There is still so much we dont know about the virus, and we are still learning that things could go south at any moment. Its not time for a victory lap at all.

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AMD responds to motherboards misreporting power telemetry – Mainboard – News – HEXUS

June 14th, 2020 7:49 am

Yesterday, in the wake of reports that AMD motherboard vendors have applied BIOS firmware to purposely misreport key power telemetry, AMD issued a statement to Tom's Hardware. It said that it has seen these reports, and that it is going to investigate further. The main worry is that while motherboard vendors have made these changes to squeeze the best performance from AMD silicon, a side effect could possibly be felt in processor stability or longevity.

Winding back a little, this story emanated from a hardware analysis and reporting feature introduced by the developers of HWinfo recently. The feature is dubbed Power Reporting Deviation, and in the words of the authors it "tells how much the CPU telemetry seen by the CPU differs from real world (expected) data". Furthermore, HWinfo fields an accusation against vendors, saying the deviation "is usually caused by mainboard vendor (often intentionally) providing wrong calibration data in BIOS (AGESA) to fool the CPU to run at a higher power than the limit for the SKU".

Of course the motherboard market is very competitive, better performance sells, and the manufacturers appear to be indulging in one-upmanship, by hook or by crook. In effect these motherboard vendors are secretly overclocking your AMD processor, by fiddling the data sent to AMD's Adaptive Voltage and Frequency Scaling (AVFS) algorithms.

HWinfo devs observed the above CPU power reporting deviation on a Ryzen 9 3900X running Cinebench

AMD's response is to the above revelations at this time is to soothe user-concerns. It says that while it is looking into the accuracy of the reports, AMD processors contain an array of safeguards which should still maintain CPU safety and longevity. For clarity the full statement is below:

Going forward it will be interesting to see if further investigations by AMD finds that these motherboard firmware misreporting tweaks are indeed damaging, and whether its board partners will continue to implement them now this info is in the open. Lastly, change will depend on whether AMD puts pressure on board partners to alter their behaviour.

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Not so sleepless in Akita: The secrets of the Japanese prefecture getting the most Zs – The – The Mainichi

June 14th, 2020 7:49 am

A person is seen walking in the streets of Akita in this file photo. (Mainichi/Kaho Shimokobe)

AKITA -- Getting a good night's sleep is essential to leading a healthy life, and in Japan it's the people of the northern prefecture of Akita who are getting the most pillow time, and the only people in the entire country to manage over eight hours in bed per day on average. The Mainichi Shimbun sat down with a sleep expert to find out their secrets.

According to the results of the Internal Affairs and Communications Ministry Statistics Bureau's 2016 "social and lifestyle basic research," average sleep time in Japan stood at seven hours and 40 minutes, while that of Akita Prefecture residents was eight hours and two minutes. Compared to those living in Saitama Prefecture, north of Tokyo, who got the least sleep at an average of seven hours and 31 minutes, Akitans snoozed at least half an hour longer.

Former Japanese Society of Sleep Research chairman and current Akita Prefectural Mental Health and Welfare Center director Tetsuo Shimizu explains that the possible main cause of longer sleep hours is that senior citizens make up a large part of Akita Prefecture's population. The Cabinet Office's 2019 Annual Report on the Aging Society says 36.4% of the prefecture's population was aged 65 and up in 2018, making it the only prefecture with a percentage higher than 35. Shimizu says one can argue that the more retired people there are, the more people there are with the time to have a proper sleep.

Shimizu also noted other rankings that appear in the Statistics Bureau's research, such as that for commuting times. Akita Prefecture placed 43rd, tied with three other prefectures including Aomori, for the second shortest time. The prefectures with the three longest commuting times -- Kanagawa, Chiba and Saitama, all bordering Tokyo -- are also the prefectures with the shortest sleep hours.

"Akita Prefecture is so far away from a major metropolitan area and it is also a major farming prefecture. Many residents probably spend only limited time on commuting," says Shimizu.

Furthermore, Shimizu points to the average bedtime of the Akitans as a factor contributing to their country-topping shuteye stats. According to one of the charts in the lifestyle research, Akita Prefecture residents go to bed at 10:33 p.m. on average, earliest in the country. The early bedtime is evidence that there are many older residents with moved-up sleep-wake cycles, and Shimizu comments, "We don't have many daylight hours in winter here and it gets freezing cold, so people would be more likely to say, 'Let's not waste money for kerosene and get in bed already.'"

Longer sleeping hours would seem to promise health benefits for Akitans. But according to the Health, Labor and Welfare Ministry's 2015 longevity list broken down by prefecture, Akita is second-last for men, at 79.51 years, and fourth from the bottom for women at 86.38 years.

Shimizu comments, "Akitans like drinking, so I suspect there are many of them who drink a lot before going to bed and just pass out. That might be negatively affecting the benefits of sleep." Backing Shimizu's claim, Statistics Bureau research on household spending in prefectural capitals and government-designated major cities showed that people in the city of Akita spent the most money on alcohol per year, averaging 55,920 yen (about $510) in 2017 through 2019, highlighting Akitans' love of drinking.

(Japanese original by Hiroshi Takano, Akita Bureau)

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Crush: How Stadium Heroes Bon Jovi Reclaimed The Rock Scene – uDiscover Music

June 14th, 2020 7:49 am

After their meteoric rise in the 80s, Bon Jovi spent most of the next decade weathering the trends and outlasting the tag of being a hair-metal band. After the hard-rockin hedonism of Slippery When Wet and New Jersey , both 90s albums (Keep the Faith and These Days) were about getting serious. There were more epics, more stories and a lot less fist-waving. Both had darker lyrics than usual, and Keep the Faith included Dry County, their first and only ten-minute track. The results were critical praise but a lower commercial profile. For the first time, the Jersey lads were in danger of a long-term career built on playing their old hits.

But Crush changed all that, rebooting the band when it arrived in June 2000. The album opens with a trio of hit singles, but there isnt a song here that wouldnt jump right out of the radio. Its really the first Bon Jovi album that doesnt aim for a unified sound, giving each track a feel of its own. They do sleek and modern, they do guitar-slinging retro, post-grunge and pure pop, depending on what a song calls for. There are also a few hints of the Americana direction theyd head in over the next decade.

Listen to Crush on Apple Music and Spotify.

Much of Crushs success can be credited to an infusion of new blood. Bassist Hugh McDonald was now settled in the band, having replaced Alec John Such in Bon Jovis first-ever personnel change a move that initially shocked fans who thought the five-way partnership was unshakeable. Another key player who took a backseat this time around was songwriter Desmond Child, who added the hit sheen to You Give Love a Bad Name and Livin On A Prayer. Jon Bon Jovi and Richie Sambora did the lions share of writing on Crush and the main co-writer was Billy Falcon, an upstart whose only previous major credit was co-writing (with Bon Jovi) Sometimes Its a B__ch for Stevie Nicks.

Most surprisingly, theres no big-name producer involved with Crush. Hitmaker Bruce Fairbairn was set to produce before his sudden heart attack, followed by Metallica man Bob Rock who was also considered. Finally, Bon Jovi and Sambora decided to co-produce with Luke Ebbins a young guy with plenty of ideas and zero hits to his credit. The gamble paid off, and Crush came out sounding polished but fresh, with no obvious fingerprints on it.

While theres more to Crush than its hit singles, lets dive right into the hit singles. For most bands, Its My Life is the kind of song that comes along once in a career an undeniable anthem, with a universal message and an unshakeable hook. From the two pounded chords that open, it has the sparkle of a pop hit, but its also steeped in classic rock. During promotions for the album, Jon Bon Jovi freely admitted he pinched the songs title and attitude from the Animals. The lyric also namechecks Sinatra and checks in with Tommy and Gina from Livin On a Prayer turns out theyre doing fine and Sambora caps it all off with a talkbox solo, likely the last one to appear on a hit single.

The second single, Say It Isnt So, pulls off the neat trick of sounding like Humble Pie in the verses and The Beatles in the choruses, while Thank You for Loving Me is the albums obligatory ballad, this time done with real strings (and a nice Sambora riff at the very end).

Sambora does some of his best work between the lines, including a few big moments on Next 100 Years, which is a three-minute song with a four-minute coda. It starts as a catchy love song, then pulls a chanted Hey Jude-type fade before the band revs up and Sambora cuts loose. Its a live-sounding moment and tops the list of singles that should have been.

In the period leading up to the 90s and then post-9/11, Bon Jovi got political, but Crush marked the bands return to pure, uncomplicated fun. Long-haul fans doubtlessly appreciated Just Older, a rousing tune that argued hitting middle age was no big deal. And anyone who remembered the 70s had to appreciate Captain Crash & the Beauty Queen from Mars, the only Bon Jovi song that clearly nods to the glitter era. (Even the title sounds like a lost Mott the Hoople track). The finale, One Wild Night, is such a fist-waver that it became the title of a live album a year later.

But the buried treasure on Crush is I Got the Girl, tucked away toward the end. Musically it encapsulates the album, starting as moody electronic pop and then chord-slinging in the chorus. Lyrically it appears to be one more Bon Jovi song about lucking out and finding the perfect partner, until he comes up with the easy-to-miss line the Queen of Hearts will always be a five-year-old princess to me. Yes, hes singing about his daughter, pulling the same narrative trick Chuck Berry did on Memphis. Its the kind of moment that keeps Bon Jovi honest, and a little endearing: Behind all that streamlined pop and arena fireworks sits a beaming dad.

Crush can be bought here.

Listen to the best of Bon Jovi on Apple Music and Spotify.

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Nanotechnology for Healthcare Market Global Competitions and Business Outlook 2020 to 2026 – News Collective

June 14th, 2020 7:48 am

The report discusses many vital industry facets that influence global Nanotechnology for Healthcare Market industry acutely which includes extensive study of competitive edge, latest advancements, region-wise industry environment, contemporary market and emerging latest trends, leading market contenders, and current tendency of the consumers. The report also oversees market size, market share, growth rate, revenue, and CAGR reported previously along with its forecast estimation.

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Global Nanotechnology for Healthcare Market Analysis Report includesTop Companies:Amgen, Teva Pharmaceuticals, Abbott, UCB, Roche, Celgene, Sanofi, Merck & Co, Biogen, Stryker, Gilead Sciences, Pfizer, 3M Company, Johnson & Johnson, Smith & Nephew, Leadiant Biosciences, Kyowa Hakko Kirin, Shire, Ipsen, Endo International along with their company profile, growth aspects, opportunities, and threats to the market development. This report presents the industry analysis for the forecast timescale. An up-to-date industry details related to industry events, import/export scenario, market share is covered in this report.

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Nanotechnology for Healthcare Marketreport includes the estimation of market size for value (million USD) and volume (M Sqm). Both Top-down and bottom-up approaches have been used to estimate and validate the market size of Nanotechnology for Healthcare Market, to estimate the size of various other dependent submarkets in the overall market.

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INBRAIN Neuroelectronics receives funding to push forward the development of graphene-based implants for brain disorders – Graphene-Info

June 14th, 2020 7:48 am

INBRAIN Neuroelectronics, a spin-off of the Catalan Institute of Nanoscience and Nanotechnology (ICN2), the Barcelona Institute of Science and Technology (BIST) and ICREA, has received funding from Sabadell Asabys and Alta Life Sciences, as well as ICF and Finaves, which will allow the company to speed up the development of novel graphene-based implants to optimize the treatment of brain disorders, such as Parkinsons and epilepsy.

INBRAIN Neuroelectronics was established in 2019 with the mission of developing brain-implants based on graphene technology for application in patients with epilepsy, Parkinsons, and other neuronal diseases. These smart devices, built around an innovative graphene electrode, will decode with high certainty neural signals from the brain and produce a therapeutic response adapted to the clinical condition of the specific patient.

The company is designing the least invasive and smartest neural interface that, powered by artificial intelligence and the use of Big Data, will have the ability to read and modulate brain activity, detect specific biomarkers, and trigger adaptive responses to deliver optimal results in personalised neurological therapies. So far, the technology has been validated in in-vitro and in-vivo biocompatibility and toxicity tests and has been successfully used to complete studies on small animals. Recently, INBRAIN began tests on large animals with the aim of ensuring that these graphene devices are safe as well as superior to current solutions based on metals such as platinum and iridium. The company also plans to start human studies soon.

INBRAIN was founded, among others, by ICREA Prof. Jose Garrido, leader of the ICN2 Advanced Electronic Materials and Devices Group, Prof. Kostas Kostarelos, leader of the ICN2 Nanomedicine Group, and Dr. Anton Guimer, a researcher at the Spanish National Centre of Microelectronics (IMB-CNM).

Within the framework of the Graphene Flagship, which is a European macroproject, explains Prof. Garrido, we were able to develop this novel graphene-based technology that will allow measuring and stimulating neuronal activity in the brain with a resolution much higher than that of current commercial technologies.

Throughout 2019, the incorporation of INBRAIN was a priority project for the ICN2 Business and Innovation Department, which coordinated the technology transfer process and successfully orchestrated the licensing of this high-potential technology.

Minimally invasive electronic therapies represent a revolutionary alternative with less potential cost for health systems, comments Carolina Aguilar, CEO of INBRAIN and a former global executive at Medtronic in the field of neuro-stimulation. In our case, the application of new 2D materials such as graphene represents a real opportunity to understand the brain workings in order to optimise and personalize the treatment.

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Chan Zuckerberg Initiative awards $1.49 million to Stanford researchers | The – Stanford University News

June 14th, 2020 7:47 am

by Stanford Medicine on June 13, 2020 1:30 pm

The Chan Zuckerberg Initiative (CZI) has awarded $1.49 million to research projects involving Stanford Medicine scientists who will investigate emerging ideas about the role of inflammationin disease. The grants will be awarded over a two-year period.

Ami Bhatt is one of the researchers on the Analyzing how inflammation affects the aging brain project that will be receiving funds from the Chan Zuckerberg Initiative. (Courtesy Stanford Medicine)

CZI is a philanthropic organization established byFacebookfounder Mark Zuckerberg and his wife, Priscilla Chan, in 2015.

Following are short descriptions of the projects, their funding amounts and the names of their investigators (lead investigators are listed first):

Analyzing how inflammation affects the aging brain ($525,000): ANNE BRUNET, professor of genetics; AMI BHATT, assistant professor of genetics and of hematology; CHRIS GARCIA, professor of structural biology and of molecular and cellular physiology.

Imaging gut immune cells and microbes to understand health and disease($300,000): LUCY ERIN OBRIEN, assistant professor of molecular and cellular and biology; KC HUANG, professor of bioengineering and of microbiology and immunology.

Studying vascular disease in black and Hispanic patients ($525,000): JOSEPH WU, professor of cardiovascular medicine and director of the Stanford Cardiovascular Institute; ELSIE GYANG ROSS, assistant professor of vascular surgery and of biomedical informatics research; and PHILIP TSAO, professor of cardiovascular medicine.

Understanding how stress and social disparity affect preterm birth ($140,000): Jingjing Li, assistant professor of neurology (UCSF); GARY SHAW, professor of pediatrics; and DAVID K. STEVENSON, professor of pediatrics.

Read this article and more on the Stanford Medicine website.

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Aerpio Hosting Key Opinion Leader Call on a Novel Mechanism for the Treatment of Glaucoma – Yahoo Finance

June 14th, 2020 7:47 am

CINCINNATI, June 08, 2020 (GLOBE NEWSWIRE) -- Aerpio Pharmaceuticals, Inc. (Aerpio) (ARPO), a biopharmaceutical company focused on developing compounds that activate Tie2 to treat ocular diseases and diabetic complications, today announced that it is hosting a key opinion leader (KOL) call on a novel mechanism for the treatment of glaucoma on Friday, June 12, 2020 at 11:30am Eastern Time.

The call will feature presentations by Dr. Paul Kaufman M.D. (University of Wisconsin) and Dr. Janey Wiggs, M.D., Ph.D. (Massachusetts Eye and Ear Infirmary and Harvard Medical School), who will discuss the current glaucoma treatment landscape and unmet medical needs, as well as the role of the Tie2 receptor in maintaining intraocular pressure. Drs. Kaufman and Wiggs will be available to answer questions at the conclusion of the event.

Aerpio's management team will also discuss its pipeline candidate, razuprotafib (formerly AKB-9778), for treating patients with glaucoma. Razuprotafib is a small molecule inhibitor that restores Tie2 activation in Schlemms canal and lowers intraocular eye pressure (IOP) via decreasing resistance to outflow from the eye. Razuprotafib has been formulated as a once or twice-daily topical eye drop and is entering a Phase 2 clinical trial in Q3:20, with top line data expected in Q1:21.

Aerpio recently announced positive and statistically significant intraocular eye pressure (IOP) reduction in a Phase 1b trial of 43 glaucoma patients, when razuprotafib was added to prostaglandin treatment. This data set is summarized here.

Paul Kaufman, M.D. is the Ernst H. Brny Emeritus Professor of Ocular Pharmacology and past Chair of the Department of Ophthalmology & Visual Sciences at the University of Wisconsin School of Medicine and Public Health, in Madison, Wisconsin. He is a physician-scientist, specializing in glaucoma and studying the mechanisms of aqueous humor formation and drainage, and the age-related loss of near vision. Dr Kaufman is a past President and past Executive Vice President of the Association for Research in Vision and Ophthalmology (ARVO), past President of the International Society for Eye Research (ISER), and has served on the US National Advisory Eye Council and numerous foundation and corporate scientific advisory boards. He has had continuous research funding from the US National Eye Institute for 40 years and from numerous private foundations, has authored over 375 original scientific articles and 75 book chapters, co-edited several textbooks including the most recent editions of Adlers Physiology of the Eye, and received numerous honors and awards including the Friedenwald Award from ARVO and the Balazs Prize from ISER. He was Editor-in-Chief of Investigative Ophthalmology & Visual Science from 2008 through 2012. Dr. Kaufman also holds an honorary Doctor of Medicine degree from Uppsala University in Sweden, where he was a post-doctoral research fellow.

Janey L. Wiggs, M.D., Ph.D. is a physician-scientist at the Massachusetts Eye and Ear Infirmary and Harvard Medical School. She is currently the Paul Austin Chandler Professor of Ophthalmology and is the Vice Chair for Clinical Research in Ophthalmology at Harvard Medical School. She also directs the CLIA-certified genetic testing laboratory at the Massachusetts Eye and Ear Infirmary and is a co-director of the Ocular Genomics Institute and co-director of the Glaucoma Center of Excellence. Dr. Wiggs received her B.A. and Ph.D. degrees in biochemistry from the University of California at Berkeley and her M.D. degree from Harvard Medical School. She did post-doctoral training in molecular genetics under the direction of Dr. Ted Dryja. Dr. Wiggs completed the ophthalmology residency at the Massachusetts Eye and Ear Infirmary and received fellowship training in glaucoma and also in medical genetics and is certified by the both the American Board of Ophthalmology and the American Board of Medical Genetics. Dr. Wiggs research program is focused on the discovery and characterization of genetic factors that contribute to the blinding eye disease glaucoma and is funded by the National Eye Institute (NEI) as well as other nonprofit foundations. She is investigating the genetic etiologies of both early-onset and adult forms of glaucoma and is the PI of the NEIGHBORHOOD consortium for gene discovery in primary open angle glaucoma and is a founding member of the International Glaucoma Genetics Consortium (IGGC). She has also participated in research programs funded by the US-INDO joint working group (NEI) and the NEI eyeGENE consortium. Dr. Wiggs was the inaugural chair of the Genetics Group for ARVO and is an ARVO gold fellow. She currently serves on the editorial boards of IOVS, JAMA Ophthalmology, Molecular Vision, Journal of Glaucoma, and Annual Reviews in Vision Science. She is a member of the scientific advisory boards for the Glaucoma Research Foundation, Research to Prevent Blindness and the Glaucoma Foundation, and is a past member of the Advisory Council of the National Eye Institute. She has received the Heed Award, the Heed/Knapp Award, the Research to Prevent Blindness Scholar Award, the AAO Honor Award, the Lew Wasserman Merit Award, the Alcon Research Award, the David L. Epstein award from the ARVO Foundation and was a winner of the NEI Audacious Goal competition. She is an elected member of the Glaucoma Research Society, the American Ophthalmological Society, the Academia Ophthalmologica Internationalis and the National Academy of Medicine.

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About RazuprotafibRazuprotafib binds to and inhibits vascular endothelial protein tyrosine phosphatase (VE-PTP), an important negative regulator of Tie2. Decreased Tie2 activity contributes to vascular instability in many diseases including diabetes and more recently has been shown to contribute to the development of increased IOP and glaucoma. Razuprotafib activates the Tie2 receptor irrespective of extracellular levels of its binding ligands, angiopoietin-1 (agonist) or angiopoietin-2 (antagonist) and may be the most efficient pharmacologic approach to maintain normal Tie2 activation. Aerpio is studying a topical ocular formulation of razuprotafib in open angle glaucoma and exploring the utility of subcutaneous razuprotafib for diabetic complications, including diabetic nephropathy.

About Aerpio PharmaceuticalsAerpio Pharmaceuticals, Inc. is a biopharmaceutical company focused on developing compounds that activate Tie2 to treat ocular diseases and diabetic complications. Recently published mouse and human genetic data implicate the Angpt/Tie2 pathway in maintenance of Schlemms canal, a critical component of the conventional outflow tract. The Companys lead compound, razuprotafib (formerly AKB-9778), a first-in-class small molecule inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP), is being developed as a potential treatment for open angle glaucoma, and the Company intends to investigate the therapeutic potential of razuprotafib in other indications. The Company is also evaluating development options for ARP-1536, a humanized monoclonal antibody, for its therapeutic potential in the treatment of diabetic vascular complications including nephropathy and diabetic macular edema (DME). The Companys third asset is a bispecific antibody that binds both VEGF and VE-PTP which is designed to inhibit VEGF activation and activate Tie2. This bispecific antibody has the potential to be an improved treatment for wet age-related macular degeneration and DME via intravitreal injection. Finally, the Company has exclusively out-licensed AKB-4924 (now called GB004), a first-in-class small molecule inhibitor of hypoxia-inducible factor-1 (HIF). GB004 is being developed by AKB-4924s exclusive licensor, Gossamer Bio, Inc. (GOSS). For more information, please visit http://www.aerpio.com.

Forward Looking StatementsThis press release contains forward-looking statements. Statements in this press release that are not purely historical are forward-looking statements. Such forward-looking statements include, among other things, the Companys product candidates, including razuprotafib, ARP-1536 and the bispecific antibody asset, the clinical development plan therefor and the therapeutic potential thereof, the Companys plans and expectations with respect to razuprotafib and the development therefor and therapeutic potential thereof in addressing COVID-19 and the intended benefits from the Companys collaboration with Gossamer Bio for GB004, including the continued development of GB004 and the milestone and royalty payments related to the collaboration. Actual results could differ from those projected in any forward-looking statements due to several risk factors. Such factors include, among others, the continued development of GB004 and maintaining and deriving the intended benefits of the Companys collaboration with Gossamer Bio; ability to continue to develop razuprotafib or other product candidates, including in indications related to COVID-19; the inherent uncertainties associated with the drug development process, including uncertainties in regulatory interactions, the design of planned or future clinical trials, commencing clinical trials and enrollment of patients in clinical trials; obtaining any necessary regulatory clearances in order to commence and conduct planned or future clinical trials; the impact of the ongoing COVID-19 pandemic on the Companys business operations, including research and development efforts and the ability of the Company to commence, conduct and complete its planned clinical activities; and competition in the industry in which the Company operates and overall market conditions; and the additional factors set forth in our Annual Report on Form 10-K for the year ended December 31, 2019, as updated by our subsequent Quarterly Reports on Form 10-Q and our other subsequent filings with the SEC.

These forward-looking statements are made as of the date of this press release, and the Company assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those projected in the forward-looking statements, except as required by law. Investors should consult all the information set forth herein and should also refer to the risk factor disclosure set forth in the reports and other documents the Company files with the SEC available at http://www.sec.gov.

Investors & Media:Gina MarekVP Financegmarek@aerpio.comOrInvestors:Irina KofflerLifeSci Advisorsikoffler@lifesciadvisors.com

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Sungeun Kim wins SUNY Oswego Provost’s Award for Scholarly and Creative Activity – NNY360

June 14th, 2020 7:47 am

OSWEGO - Dedication to researching complicated neurological disorders and an impressive publication record have earned Sungeun Kim of the electrical and computer engineering faculty the SUNY Oswego Provosts Award for Scholarly and Creative Activity.

Nominator and fellow electrical and computer engineering faculty member Marianne Hromalik noted that, since Kim started at SUNY Oswego in 2016, he has sustained, in addition to his teaching and administrative duties, an impressive record of cutting-edge research.

Kims primary research includes innovative methods for detecting blood-based biomarkers for Alzheimers as well as the integration of the analysis of multiple omics (proteomics, genomics, transcriptomics, etc.) data with neural imaging and clinical data to allow for early detection of Alzheimers and other complex diseases, Hromalik wrote. This work not only represents rapidly expanding research at the very edge of discovery but also has significant medical and social value.

Hromalik praised his track record of peer-reviewed publications -- 93 in all, 21 since joining the Oswego faculty -- as well as his 11 peer-reviewed conference presentations. Kim, who earned his Ph.D. from Purdue Universitys School of Electrical and Computer Engineering, has published two pieces in the prestigious journal Nature, and serves as a peer reviewer for several well-regarded academic journals as well.

Particularly since arrival at Oswego, he has constantly produced outstanding research work demonstrating an extreme productivity in publishing peer-reviewed work and obtaining external funding, wrote ECE faculty member Adrian Ieta. He won three external grants in the area of Alzheimers disease and Parkinsons disease.

Ieta also credited Kim involving Oswego undergraduate students in his research, exposing them to this vital research area, as well as providing instrumental work supporting the college engineering programs earning sought-after ABET accreditation in 2019.

Sungeun is a great colleague, always ready to help, to take up new challenges related to teaching, research or other tasks, Ieta wrote. He has an amazing ability to redefine himself and adjust to objectives and requirements. His teaching performance in introductory and advanced courses is excellent.

Kim has provided additional service to the department and its students by revitalizing ECEs capstone design proposal and capstone design courses and has imparted many of his excellent research techniques to seniors in reorganizing and redesigning their project planning processes, Hromalik said.

Dr. Kims ground breaking research has provided deep understanding of mechanistic insights into the molecular basis of brain disorders and identification of new potential therapeutic targets and diagnostic/biomarker strategies, wrote research colleague Kwangsik Nho of Indiana Universitys Center for Neuroimaging.

He is an excellent researcher and an expert on mechanisms of neurodegenerative disorders such as Alzheimers disease at cellular, molecular and systems levels, Nho added. I have never seen anyone develop complex analytic paradigms and statistical/computational approaches and apply them to highly complex data sets as quickly as Dr. Kim.

I am highly impressed by his research accomplishments at your institution, wrote Li Shen, a professor of informatics and Senior Fellow at the Penn Institute for Biomedical Informatics at the University of Pennsylvania.

He is one of the few people I know that has published consistently in imaging, genetics, computing, neuroscience and disease-specific journals, Shen added. This very clearly demonstrates that he is multidisciplinary. This is a highly desirable trait in a world of modern research and teaching that thrives of the use of multiple disciplines to solve complex problems.

The Provosts Award for Scholarly and Creative Activity is designed as recognition of a significant accomplishment in scholarly or creative activity within ones field of study.

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Westerleigh resident is alive because of stem cell therapy by his doctor — for free. Heres his story. – SILive.com

June 13th, 2020 12:47 pm

Stephen Raffone had difficulty breathing. He coughed up sputum and was wheezing. Doctors told him he had chronic obstructive pulmonary disease (COPD), a condition that causes blocked airflow from the lungs.

As a result, he was being treated for stage 4 COPD.

His doctor was also treating him for cellulitis, an inflammatory and painful bacterial skin infection where extremities appear red and swollen and the area can feel hot and tender to the touch, as well as poor circulation.

My legs were beginning to get ulcerated and they were breaking down, said Raffone.

He was administered the Roman Catholic Churchs Last Rites three times several years ago when he was a patient in Richmond University Medical Center.

Raffone, who is now 63, was in need of a lung transplant.

He was a heavy smoker and it took its toll. However, because he was in a weakened state due to other serious health conditions, doctors told him hed never survive the surgery.

The Westerleigh resident, who has been in need of 24-hour care for the last several years, requires the assistance of two nurses who rotate 12-hour shifts.

One, a close family friend, suggested Raffone see a medical specialist who performs stem cell therapy, a procedure where the patients own stem cells are removed, treated and returned to his or her own body after a conditioning regimen.

She contacted Dr. Alexandre M. Scheer of Scheer Medical Wellness and he agreed to see Raffone.

Dr. Alexandre M. Scheer (Courtesy/Stephen Raffone)Staten Island Advance

But since Raffone was unable to leave his home, Scheer visited Raffone for a consultation and to evaluate his condition.

Fast forward a year and a half and Scheer has continued with those visits almost every Saturday free of charge also underwriting the cost for treatments, as well as Uber rides from Manhattan to Staten Island, in order to perform the stem cell procedure.

RAFFONES NURSE SPEAKS

One of Raffones nurses recounted Raffones journey.

She explained that when they started to explore stem cell therapy she placed calls to several doctors, but the biggest thing that jumped out at her was the astronomical cost.

But there was something about Dr. Scheer. And I just knew he was the right one, said the registered nurse for more than 30 years. "He wasnt interested in money. His goal is his patients outcome. Stephen did pay for the first set of treatments, but since then, Dr. Scheer has not taken a dime.

When the patient began treatments, the first therapy was a tremendous boost and then every week after that he was treated for seven weeks. In the beginning, the doctor visited every week and brought whatever supplies was needed. The PRP (platelet rich plasma) treatments are daily.

I draw the blood, I spin the blood," she said. We have a small centrifuge here so it separates the blood. The PRP is given by a nebulizer. It takes about 30 minutes. And once a week he gets a protein enriched plasma, which takes about a half hour, she added.

He has chronic venous ulcerations of the both lower extremities from the knee down, she said.

Raffone has end stage COPD. But since he started the treatments, hes gone to the hospital only once. And he has tested negative for antibody COVID-19.

RAFFONES TREATMENT BEGINS

Raffone was required to install the centrifuge machine with needles and plasma tube, a laboratory device used for the separation of fluids, gas or liquid, based on density. Separation is achieved by spinning a vessel containing material at high speed.

Initially, Dr. Scheer sent a plastic surgeon to my home to perform liposuction, a type of fat-removal procedure used in plastic surgery, where they separate the fat and preserve the stem cells, Raffone said. They did this four times weekly at the beginning. Dr. Scheer has been visiting my home pretty much each week since Sept. 22, 2018. But right now the stem cell therapy is done once a month."

They draw blood out and spin it. Its all done through IV. Right now stem cell infusion is done once a month and daily through a nebulizer. Dr. Scheer does it on Saturday and my nurse and dear friend to Dr. Scheer does it during the week. My house looks like a hospital. Dr. Scheer is keeping me alive and everything is healing up so well, said Raffone.

Stephen Raffone's left leg before stem cell treatment. (Courtesy/Stephen Raffone)Staten Island Advance

Raffone says he wanted to come forward with his account at this time because hes so grateful and especially today when so many negative stories are in the news.

We need some good stories. There are very few people like Dr. Scheer, especially now during the COVID-19 crisis, he said.

My nurse draws the blood and puts it in a centrifuge when the doctor cant make it from the city. But Dr. Scheer is still coming to my house in spite of the COVID-19 crisis," Raffone continued.

Raffone has been confined to a bed one that he says turns you from side to side and upside down. But Dr. Scheer is confident that when restrictions are lifted and physical therapy sessions resume, Raffone will be able to walk.

The stem cell therapy is not only helping to combat Raffones COPD, but it has also helped him with cellulitis on his leg.

Stephen's Raffone healed left leg after stem cell therapy. (Courtesy/Stephen Raffone)Staten Island Advance

Scheer, a staunch supporter of stem cell therapy, has a background in neurosurgery and regenerative medicine. He performs surgery at several surgical centers in Manhattan.

It has to do with the amount of cells your bone marrow," he said. What we do is . . . saturate the body with stem cells. It suppresses the inflammatory response. COVID-19 also is an inflammatory disease. The COVID-19 kills the lungs. So you dont have oxygen going through. The stem cells protect, so you have continual oxygen transfer.

Dr. Scheer, who practices at Sheer Medical Wellness in Manhattan, says you can regenerate yourself.

I want my patients to be fine. I will pay for the patient. Im happy Stephens alive. And then my life is made. Stephen will now be able to walk after physical therapy. He was on 12 liters of oxygen daily. Hes now on two liters. I know his nurse very well and thats how we connected. The stem cell treatment is the appropriate treatment for him. I pay out of pocket because I know the right treatment for his condition," he added.

Dr. Scheer points out in China and in Israel stem cell therapy is the treatment they use for COVID- 19.

Its where you take Eastern and Western medicine and put it together. The patients body and will to live and having the right outlook on life has a lot to do with proper health. Our group is so big. We have 40 different doctors in my practice. Im the medical director, he said. Stem cell treatment is the future of medicine. At $10,000 a treatment, its very expensive. And the number depends on the issue at hand.

THE INITIAL CALL

When Scheer spoke to Raffone, He said I cant get out of bed,' the doctor said. "I drove to Staten Island and I got to know Stephen and his family very well. Its not a one-time treatment. Im seeing him on a weekly basis. There is a relationship that occurs. And thats what matters and thats what keeps people alive. Hope is what keeps them alive. And Im doing this since 2001. The treatment involves platelet enriched plasma that suppresses inflammatory reactions in the lungs. Whats happening is youre able to suppress the inflammatory reaction. His legs and his heart are getting better as well. This is a treatment until we can get him walking.

Scheer says Raffone must undergo physical therapy in oder for him to walk around freely.

And hell be able to travel to my office. Im not giving up on him. Im paying out of pocket. A quarter of my patients, I pay for. Stephen has gone through so much. Hes alive because of stem cell therapy. And due to his lung condition with COVID, he has not contracted it."

Scheer says its been a team effort, with multiple doctors coming into play.

Stephen is keeping himself alive. Im just the tool that can help. I just do the best I can for as many people as I can.

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Westerleigh resident is alive because of stem cell therapy by his doctor -- for free. Heres his story. - SILive.com

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Regenerative Therapy Options for Horses With Osteoarthritis – TheHorse.com

June 13th, 2020 12:47 pm

Biologic, or regenerative, therapies have altered the way many equine veterinarians treat problematic joints. Some of the most mainstream and popular modalities they currently use to manage osteoarthritis (OA) in horses are autologous conditioned serum, autologous protein solution, platelet-rich plasma, and mesenchymal stem cells.

Most biologic therapies involve collecting and concentrating the horses natural anti-inflammatory and regenerative proteins or cells so they can be injected into an area of pathology (disease or damage) in the same horse.

Autologous conditioned serum is a cell-free extract of whole blood that has been processed to contain high concentrations of interleukin-1 receptor antagonist protein (IRAP), a naturally occurring anti-inflammatory protein within the body. It is marketed under the trade names IRAP and IRAP II.

When preparing ACS, veterinarians collect venous blood in a proprietary syringe system that encourages porous glass beads to bind with white blood cells. During an incubation process the bound white cells release high concentrations of IRAP. The veterinarian then draws the serum off into small portions and freezes it for future injection into arthritic joints. In clinical studies of ACS, researchers have reported improved synovial membrane (joint surface lining) health, stimulation of natural IRAP production, and improved lameness.

Platelet rich plasma is blood plasma thats been centrifuged or filtrated to have a higher concentration of platelets than whole blood. Many horse owners are familiar with PRP and its use in tendon and ligament injuries; however, veterinarians are using it more regularly for treating joint disease.

One of platelets roles in the body is to modulate tissue healing. They do so by releasing growth factors and signaling molecules that initiate repair and promote anabolic (supporting tissue growth) effects. Veterinarians have capitalized on this ability by injecting high concentrations of platelets directly into damaged or inflamed regions. Because many PRP systems allow for stallside preparation, it is a convenient option for immediate treatment without the hassle of incubation or culturing in the lab, as is the case with ACS and stem cell preparation, respectively.

Historically, equine veterinarians have primarily used PRP to help treat soft tissue injuries. More recent work has led to intra-articular (in the joint) use with promising results. Although researchers have demonstrated how platelet-derived products work in vitro (in the lab) and veterinarians have seen promising anecdotal results in vivo (in the live horse), theyve yet to produce evidence-based confirmation of its clinical efficacy.

Mark Revenaugh, DVM, owner of Northwest Equine Performance, in Mulino, Oregon, says the main factors standing between researchers ability to gather objective data and establish a consensus on PRPs efficacy are the high variability among preparation systems, individual patient reactivity to the product, and an unknown ideal concentration of platelets for particular injuries.

Most practitioners cant always check how many platelets are being used, he says. Depending on the system, one veterinarian may be using 100,000 platelets/milliliter and another veterinarian may be using 1 billion platelets/milliliter. These are not the same treatments, even though both are called PRP. I would love to see an industry standard develop.

Overall, PRPs positive anecdotal results and relatively easy preparation make it a useful option for treating osteoarthritis (OA) in horses.

Autologous protein solution (marketed under the trade name Pro-Stride) is essentially a hybrid of ACS and PRP. Its two-step stallside preparation process involves separating whole blood and sequestering white blood cells and platelets in a small fraction of plasma. The veterinarian then concentrates the separate blood components by filtration, leaving a solution of white blood cells, platelets, and serum proteins that provides the anti-inflammatory mediators of IRAP and the platelet-derived growth factors of PRP.

In a 2014 study out of The Ohio State University, researchers revealed that an intra-articular APS injection can significantly improve lameness, weight-bearing symmetry, and range of joint motion in horses that dont have severe lameness or significant compromise to the joint structure.

Mesenchymal stems cells are adult stem cells that can direct regeneration and repair of damaged tissue. Veterinarians have used this type of stem cell as a treatment strategy for equine soft tissue injury for some time; its only recently that veterinarians have begun using them to treat OA, and its not fully clear how they work in this capacity. Researchers working on early stem cell studies hoped to establish evidence that stem cells injected into regions of injury would develop into the respective tissue. While this hypothesis proved to be incorrect, continued research has revealed that these cells might instead have anti-inflammatory effects and the ability to recruit other stem cells to the area that could, in fact, heal damaged tissue.

The two most common forms of mesenchymal stem cells are adipose (fat)-derived and bone-marrow-derived. Some study results have shown that bone marrow sources yield smaller concentrations thanbut are superior toadipose sources in their ability to differentiate into musculoskeletal tissue. Some encouraging data supporting the use of mesenchymal stem cells for treating OA exists, but researchers have only published a small number of studies with promising results. Equine veterinarians have used MSCs to treat intra-articular soft tissue injury (meniscal and cruciate damagecartilaginous tissues and ligaments that support the stifle), with successful anecdotal results. Theyve reported more variable outcomes when using it for primary intra-articular injuries.

Carter Judy, DVM, Dipl. ACVS, staff surgeon at Alamo Pintado Equine Medical Center, in Los Olivos, California, says he currently prefers to use PRP and APS for OA treatment over MSCs. However, he admits there is much to be discovered. What will be interesting to see is how manipulating the cells and providing them with different signals and markers can make their efficacy much more potent and focused, he says.

When weighing treatment options for horses with OA, veterinarians should base their decision to use a certain biologic modality on its cost, availability, and how a horse has responded previously.

Our knowledge base of how the biologics work is improving, but we are in the infancy of understanding, Judy says. Much of the use is based on the clinical response as much as is it on the scientific data.

More:
Regenerative Therapy Options for Horses With Osteoarthritis - TheHorse.com

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Fat cells remember their diets early in life – Massive Science

June 13th, 2020 12:47 pm

Our relationship to Neanderthals has been a point of contention for over a century. It all began with an inaccurate reconstruction of the first Neanderthal ever found, which portrayed them as brutish, stooped-over cavemen (turns out, that Neanderthal was an injured old man with arthritis).

But within the last half century, scientists have noticed the many biological and behavioral similarities that show just how close our species are. While these similarities are clear from hard objects like bones and tools, perishable objects, which comprise the majority of material culture items in humans, have been lacking.

Now, scientists have discovered a Neanderthal feat that hammers another nail in the coffin of supposed Neanderthal inferiority. Last month, an international team of researchers found a small section of a twisted cord attached to a stone flake in Neanderthal site in southeastern France, dated to over 40,000 years old. This constitutes the oldest direct evidence of fiber technology ever found.

A stone flake with three distinct twisted fibers preserved (indicated by the box).

M.-H. Moncel

When artifacts are recovered from archaeological sites, they are generally imaged using high powered microscopes to zoom in on tiny marks and details on the stones. Previously, plant fibers had been found on stones at this site, but they were too poorly preserved to be interpreted. When the team examined this particular flake, they were surprised to find three distinct twisted fibers, which were then twisted together in the opposite direction to form a 3-ply cord.

While it may not sound like much, this piece of string hints at something much more significant. For one, extracting and manipulating plant fibers requires working memory, as well as understanding plant seasonality and the concept of numbers. Also, such cords are the building blocks for creating other textiles, such as baskets, fabrics, and nets. Once adopted, these objects would have been indispensable in daily life.

This little piece of string provides unprecedented insight into the lives of our extinct relatives, which, despite an abundance of genetic, archaeological, and skeletal data, have been extremely difficult to interpret. It seems as though we humans arent as unique as we like to think.

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Fat cells remember their diets early in life - Massive Science

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Renaissance Academy Class of 2020 graduates with over $17 million in scholarships – Montgomery Newspapers

June 13th, 2020 12:46 pm

PHOENIXVILLE -- On Wednesday, June 10th, 2020, seventy-three seniors graduated from the Renaissance Academy Charter School (RA). The ceremony was held at 7:00 pm and included all the RA traditional Commencement Ceremony through video. The event featured Keynote Speaker and Valedictorian speeches, various awards and scholarships presentations, as well as, the seniors being announced and recognized for earning their diplomas.

The keynote speaker, selected by student vote, was Kelly Najdawi, the K-12 Curriculum Leader of English Language Arts at RA. Born and raised in Radnor. Mrs. Najdawi graduated Magna Cum Laude from West Chester University in 2008, earning a Bachelor of Science in Education with a Middle School English Language Arts Certification. She began working at RA in 2008.

During her 11-year career at RA, Mrs. Najdawi taught English Language Arts to this graduating class in both their 7th and 8th grade years. As their teacher, she made a special connection with this class and is confident they will go on to make a real difference in the world. This class has always impressed me with their academic drive, personal voice, and understanding, so I felt they were already best prepared to take on their future. I trust them and the decisions they are going to make and expect them to positively change the status quo by using everything Renaissance has instilled in them.

Also speaking at the ceremony was Carolyn (Carly) Higgins, 2020 Valedictorian. As Carly reflected back on her time at RA, she spoke of the challenges her class faced together as a unified group. She went on to stress the importance of self-dependency and having the bravery to pursue ones goals in life even when there are powerful obstacles ahead. We have the ability to make our dreams a reality, but you have to have the courage to trust yourself first. Thats the world that I want to live in and I know you do too.

In the fall, Carly plans to be on the pre-med track with a dual major in biology and molecular genetics. While she has not yet decided on her specific college, Carly has been accepted to the Rochester Institute of Technologys Physicians Assistant Program (BS/MS) 5 year program, the University of Rochesters biological sciences program in molecular genetics, the University of Richmond; the University of Hawaii at Mnoa, and West Chester University of Pennsylvanias biology-cell and molecular program.

The RA 2020 Salutatorian, Jeremy Wenger, who will be attending Olin College of Engineering located in Needham, Massachusetts, gave his speech during a graduation achievement and awards event on Monday night. Jeremy spoke about the unity and accomplishments of his graduating class and their ability to change the world with what they know is true. Now it is our time to shape the world. We just have to be brave enough to do it.

The Renaissance Academy Charter School graduating class of 2020 includes:

Grace Katherine Abendshein (Phoenixville), Jamod O. Adams (Norristown), Mark D. Adams (Royersford), Olivia Elizabeth Andreoni (Eagleville ), Joshua David BarrancoSilva (Phoenixville ), Daniel Eric Barron (Coatesville ), Naomi Michele Bruno (Sanatoga), Gavin Daniel Budniak (West Norriton), Olivia Rose Campbell (Royersford), Giavanna M. Caperila (Phoenixville), Emily Paige Cassidy (Phoenixville), Alyssa N. Cekic (Phoenixville), Brianna Chandler (Norristown), Shaun Maria Chester (Phoenixville), Jahi Peter Clark (Norristown), Gabriel Avery Cole (Pottstown), Geoffrey James Cross Jr. (Pottstown), Emilia Anna Crow (Royersford), Susannah Jeannette Cushmore (Norristown), Cornelius I. Dairo (Norristown), Taylor Lynn Darden (Phoenixville), Gianna Rose Debro (RoyersfordA), Jonathan William DeSanto (Phoenixville), Kayla Nicole Diaz (Norristown), Samuel Miles Dooling (Norristown), Ryan James Dunn (Phoenixville) Olivia Rachel Ferst (Norristown), Nicolette G. Foster (East Norriton), Madison Elizabeth Francis (Pottstown), Avinash Suhas Ganguly (Jeffersonville), Kelly Roberta Garman (Collegeville), Morgan Elizabeth Gidney (Gilbertsville), Jaeshon Goodman-Rhodes (Norristown), Grace Riley Grenier (Jeffersonville), Kathryn Ann Guevin (Phoenixville), Shay S. Gustafson (Collegeville), Kiley Rae Henderson (Pottstown), Carolyn S. Higgins (Morgantown, PA), Kaitlin Bryn Irby (Phoenixville), Majesty Sanai Jerry (Norristown), Jurnee Ann Jessie (Norristown), Adam Christopher Johnson (Norristown), Micaiah Allen Jones (Norristown), Elisabeth Faith Kerper (Jeffersonville), Theresa Rose Kolter (Phoenixville), Malachy L. Lacy (Jeffersonville), Tyler Anthony Magyar (Pottstown), Grace Elizabeth Moreschi (Audubon) Lindsey Nicole ODonnell (Norristown), Max Victor Olstad (Phoenixville), Angelina Clair Pagano (Pottstown), Dominique Xandria Parrish-Hankins (Norristown), James Joseph Pritz IV (East Norriton), Aliyah Nicole Quill (Phoenixville, PA), Benjamin Ali-Reza Rabizadeh (Exton), Erin Kathleen Robbins (Collegeville), Tyler Steven Robbins (Jeffersonville), Trevor Mitchell Schmidt (East Norriton, PA), Lily Catherine Shaffer (Collegeville), Paige Kimberly Simon (Norristown), Lauren R. Stauch (Phoenixville), Sara Bernadette Stockett (Norristown), Lanasha Sweeper (East Norriton), Nathen Lim Te (Norristown), Devon Lynn Testa (Phoenixville), Sarah Irene Trexler (Spring City, PA), Nissi Jayanth Vinnakota (Norristown), Dominique Meghan Vinson (Conshohocken), Alexander Joseph Waskiewicz (Norristown), Cassandra Jean Waskiewicz (Norristown), Jeremy Benjamin Wenger (Royersford), Chandler D. White (Norristown), and Cole Raymond Winters (Phoenixville).

These graduates have been accepted to universities such as Rensselaer Polytechnic Institute, Dickinson College, Boston University, Bucknell University, University of Rochester, Ohio State University, Olin College of Engineering, University of Michigan, American University, George Washington University, and Swarthmore College. They have been collectively offered (to date) a scholarship total of $17,101,514.00, a new Renaissance Academy merit scholarship school record. Tracey Behrens OBrien, RA Academic and College Counselor noted that nearly all of the scholarships have been awarded to the students by the individual universities, not from scholarship search sites. It is so exciting to see an unprecedented number of students in the Class of 2020 being recognized by prestigious colleges.

Due to the current COVID-19 conditions, some of the traditional RA end-of-year senior events were held a little differently. The graduates were celebrated over five unique nights. Each night, a different link was released on the Senior Knights 2020 website. The nights had videos and live feeds with different focuses including a night for athletics and the arts; a senior class photo slideshow night; awards and the Salutatorian speech; the senior parent reveal night; the 2020 commencement ceremony; and finally, the graduates processional parade.

About this group of graduates, Upper School Principal, Michelle Boyd said, The Class of 2020 will always stand out for all that they have gone through and how they have persevered through such challenging times. The Class of 2020 displays true grit and determination--they will surely go on to change the world for the better!

The Renaissance Academy staff and Board of Trustees are so very proud of these students and wish them the very best in their future endeavors

Established in 1999, Renaissance Academy is a fully accredited K-12, award-winning, tuition-free, college prep charter school located in Phoenixville, PA. The academy is listed as one of US News & World Reports 2020 Best High School in America. For more information on the school, please visit http://www.rak12.org.The graduation video can also be viewed:RA 2020 Commencement Video (YouTube)

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Renaissance Academy Class of 2020 graduates with over $17 million in scholarships - Montgomery Newspapers

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UCD professor asked to resign from EU committee over Covid-19 claims – The Irish Times

June 13th, 2020 12:46 pm

A University College Dublin (UCD) professor, who chairs the Eurosceptic Irish Freedom Party, has been asked to resign from a leading European Union scientific committee over online claims she made about the Covid-19 pandemic.

In an hour-long interview with a popular alt-right activist on May 10th, which has been viewed hundreds of thousands of times, Prof Dolores Cahill promised to debunk the narrative of the pandemic.

Lockdown and social distancing is not needed to stop the spread of the virus, she said. People who recover are then immune for life after 10 days and deaths and illnesses could have been prevented by extra vitamins, she claimed.

People with underlying health conditions, such as cystic fibrosis, could freely engage in society during the pandemic after spending a few weeks building up their immunity in this manner, she went on.

Opposing vaccinations, Ms Cahill said politicians and the media are using Covid-19 as a fear-mongering propaganda tool to try and take away rights from people and to make them more sick and to force vaccinations on us.

However, the European Commission said the claims made by Ms Cahill, a professor of translational medicine in UCD, could cause significant harm, if taken literally.

Following this, Ms Cahill was asked to resign as vice chair of the Scientific Committee of the Innovative Medicines Initiative (IMI), a partnership between the European Commission and the drugs industry to promote new drugs.

Professor Cahill has been requested by the Chair of the Scientific Council of IMI and the Executive Director of IMI to step down from her function, the commission told The Irish Times.

While as a private person, Professor Cahill is entitled to express her points of view, these are not compatible with the scientific foundations of the Innovative Medicines Initiative, said a Commission spokesperson.

Ms Cahills claims have also caused Berlins Max Planck Institute for Molecular Genetics (MPIMG), where she worked for eight years, to distance itself, saying it did not want to be associated in any way with the claims made.

The IMI echoed these sentiments, saying that they were shocked to see her statements and that her views do not reflect those hold on Covid-19 by of IMI.

A former Max Planck colleague, Prof Hans Lehrach said he was really surprised by Ms Cahills comments: I have no idea why she says things like that, he said.

There is absolutely no proof that people recovering from the disease are immune for life, he said, reflecting the World Health Organisations understanding on the subject.

Vitamins and minerals do help the immune system, but Mr Lehrach said he would very much doubt that they would defend against the virus. The vulnerable would be pretty insane to engage widely during the pandemic.

Ms Cahill also supported the use of hydroxychloroquine to treat Covid-19, one that has been supported, too, by US president Donald Trump. The drug, she said, is safe and effective in treating the disease.

However, Prof Lehrach said that he would be very careful with hydroxychloroquine as testing had proven that it is ineffective as a treatment and has been known to cause death due to heart complications.

The original interview has since been removed by YouTube, but versions can still be found easily online and have clocked up hundreds of thousands of views. Ms Cahill has given a number of similar interviews since.

Ms Cahill is a member of the faculty at UCD school of medicine, where she is the module co-ordinator on a number of subjects, including one taught to first-year medicine students called Science Medicine and Society.

When approached for comment, UCD confirmed that she is part of the universitys faculty, but refused to comment further on her claims, saying only that they are her own views.

Ms Cahill unsuccessfully contested the general election for the Irish Freedom Party in February, eliminated on the second count in Tipperary with a total of 527 votes. She has not replied to requests for comment.

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UCD professor asked to resign from EU committee over Covid-19 claims - The Irish Times

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