header logo image


Page 54«..1020..53545556..6070..»

Advancing the Battle against Cystic Fibrosis: Stem Cell and Gene …

December 19th, 2024 2:49 am

Cystic fibrosis (CF) is a hereditary disorder characterized by mutations in the CFTR gene, leading to impaired chloride ion transport and subsequent thickening of mucus in various organs, particularly the lungs. Despite significant progress in CF management, current treatments focus mainly on symptom relief and do not address the underlying genetic defects. Stem cell and gene therapies present promising avenues for tackling CF at its root cause. Stem cells, including embryonic, induced pluripotent, mesenchymal, hematopoietic, and lung progenitor cells, offer regenerative potential by differentiating into specialized cells and modulating immune responses. Similarly, gene therapy aims to correct CFTR gene mutations by delivering functional copies of the gene into affected cells. Various approaches, such as viral and nonviral vectors, gene editing with CRISPR-Cas9, small interfering RNA (siRNA) therapy, and mRNA therapy, are being explored to achieve gene correction. Despite their potential, challenges such as safety concerns, ethical considerations, delivery system optimization, and long-term efficacy remain. This review provides a comprehensive overview of the current understanding of CF pathophysiology, the rationale for exploring stem cell and gene therapies, the types of therapies available, their mechanisms of action, and the challenges and future directions in the field. By addressing these challenges, stem cell and gene therapies hold promise for transforming CF management and improving the quality of life of affected individuals.

Keywords: CFTR gene; CRISPR-Cas9; cystic fibrosis; delivery system; gene therapy; genetic disorder; mesenchymal stem cells; stem cell therapy; vectors.

View original post here:
Advancing the Battle against Cystic Fibrosis: Stem Cell and Gene ...

Read More...

Introducing the reinvigorated AVMA Career Center – American Veterinary Medical Association

December 19th, 2024 2:48 am

Introducing the reinvigorated AVMA Career Center  American Veterinary Medical Association

More:
Introducing the reinvigorated AVMA Career Center - American Veterinary Medical Association

Read More...

Zoetis Responds to FDAs Dear Veterinarian Letter – Today’s Veterinary Business

December 19th, 2024 2:48 am

Zoetis Responds to FDAs Dear Veterinarian Letter  Today's Veterinary Business

See the article here:
Zoetis Responds to FDAs Dear Veterinarian Letter - Today's Veterinary Business

Read More...

Nonprofit seeks to boost sustainability in veterinary realm – VIN News Service

December 19th, 2024 2:48 am

Nonprofit seeks to boost sustainability in veterinary realm  VIN News Service

Here is the original post:
Nonprofit seeks to boost sustainability in veterinary realm - VIN News Service

Read More...

Patty Scharko, 2024 Distinguished Veterinarian of the Year – Clemson News

December 19th, 2024 2:48 am

Patty Scharko, 2024 Distinguished Veterinarian of the Year  Clemson News

See more here:
Patty Scharko, 2024 Distinguished Veterinarian of the Year - Clemson News

Read More...

Local Students Scrub in as Veterinarians for a Day, Gaining Hands-On Experience and Immersive Training at the World’s Largest Veterinary Conference -…

December 19th, 2024 2:48 am

Local Students Scrub in as Veterinarians for a Day, Gaining Hands-On Experience and Immersive Training at the World's Largest Veterinary Conference  Morningstar

See the original post:
Local Students Scrub in as Veterinarians for a Day, Gaining Hands-On Experience and Immersive Training at the World's Largest Veterinary Conference -...

Read More...

2024 Year in Review – Clemson News

December 19th, 2024 2:48 am

2024 Year in Review  Clemson News

Here is the original post:
2024 Year in Review - Clemson News

Read More...

Paws and profits: New leadership in the veterinary industry – DVM 360

December 19th, 2024 2:48 am

Paws and profits: New leadership in the veterinary industry  DVM 360

Here is the original post:
Paws and profits: New leadership in the veterinary industry - DVM 360

Read More...

AAHAs DEIB committee: Its evolution, key values, and future – AAHA

December 19th, 2024 2:48 am

AAHAs DEIB committee: Its evolution, key values, and future  AAHA

View post:
AAHAs DEIB committee: Its evolution, key values, and future - AAHA

Read More...

Top Science Stories of 2024 – Tufts Now

December 19th, 2024 2:48 am

Top Science Stories of 2024  Tufts Now

View original post here:
Top Science Stories of 2024 - Tufts Now

Read More...

Coalition for Veterinary Professional Associates Calls for Action: Addressing the Veterinary Workforce Shortage and Advancing the OneHealth Initiative…

December 19th, 2024 2:48 am

Coalition for Veterinary Professional Associates Calls for Action: Addressing the Veterinary Workforce Shortage and Advancing the OneHealth Initiative  Longview News-Journal

Link:
Coalition for Veterinary Professional Associates Calls for Action: Addressing the Veterinary Workforce Shortage and Advancing the OneHealth Initiative...

Read More...

Tips to keep your pets safe during the holiday season – Oklahoma City Sentinel

December 19th, 2024 2:48 am

Tips to keep your pets safe during the holiday season  Oklahoma City Sentinel

Go here to see the original:
Tips to keep your pets safe during the holiday season - Oklahoma City Sentinel

Read More...

Should They Stay Or Should They Go? Things To Know Before Taking Pets On Holiday Trips – Texas A&M University Today

December 19th, 2024 2:48 am

Should They Stay Or Should They Go? Things To Know Before Taking Pets On Holiday Trips  Texas A&M University Today

See the article here:
Should They Stay Or Should They Go? Things To Know Before Taking Pets On Holiday Trips - Texas A&M University Today

Read More...

Simple enrichment reduces boredom and boosts welfare in housed dairy cows – EurekAlert

December 19th, 2024 2:48 am

Simple enrichment reduces boredom and boosts welfare in housed dairy cows  EurekAlert

The rest is here:
Simple enrichment reduces boredom and boosts welfare in housed dairy cows - EurekAlert

Read More...

Traditional, Complementary and Integrative Medicine

December 19th, 2024 2:48 am

Traditional medicine

Traditional medicine has a long history. It is the sum total of the knowledge, skill, and practices based on the theories, beliefs, and experiences indigenous to different cultures, whether explicable or not, used in the maintenance of health as well as in the prevention, diagnosis, improvement or treatment of physical and mental illness.

Complementary medicine

The terms complementary medicine or alternative medicine refer to a broad set of health care practices that are not part of that countrys own tradition or conventional medicine and are not fully integrated into the dominant health-care system. They are used interchangeably with traditional medicine in some countries.

Herbal medicines

Herbal medicines include herbs, herbal materials, herbal preparations and finished herbal products, that contain as active ingredients parts of plants, or other plant materials, or combinations.

Original post:
Traditional, Complementary and Integrative Medicine

Read More...

Traditional medicine in the Western Pacific – World Health Organization …

December 19th, 2024 2:48 am

Communities and families in the Western Pacific Region use traditional and complementary medicine extensively for a variety of health problems, from minor ailments to life-threatening diseases. It is sometimes the only available and affordable option, especially in remote or under-served areas. Thus, it plays an important role in primary health care.

Traditional and complementary medicine is a health practice with strong historical and cultural roots. Since it has often evolved as part of a particular cultural heritage, the forms of traditional medicine vary widely across the Region. Some forms are highly developed and well documented. They are based on systematized knowledge, comprehensive methodology and historical experience. A number of less complex traditional medicine practices also exist within small and sometimes isolated ethnic groups, based largely on local experience. The knowledge may not be documented, often being transmitted orally from generation to generation.

Read the rest here:
Traditional medicine in the Western Pacific - World Health Organization ...

Read More...

New WHO and Ministry of AYUSH, Republic of India agreement signed to …

December 19th, 2024 2:47 am

Worldwide, traditional, complementary, and integrative medicine (TCI) is central to health and well-being for millions of people. At the Permanent Mission of India in Geneva today the World Health Organization (WHO) signed a new multi million five-year agreement with the Ministry of AYUSH, Government of India to boost the development of new TCI technical documents by WHO.

This collaboration will play an important role not only in the globalization of evidence-informed traditional, complementary, and integrative medicine but also in mainstreaming proven TCI practices in national health systems towards achieving universal health coverage and well-being, said Dr. Bruce Aylward, Assistant Director-General of the Universal Health Coverage and Life Course Division of WHO.

His Excellency Shri Indra Mani Pandey, Permanent Representative of India to the United Nations and other International Organizations in Geneva, in signing the agreement stated Todays signing of this agreement will not only support the development of the TCI Global Strategy - but it will also support the integration of evidence-based Traditional and Complementary Medicine in national health systems, bio-diversity conservation and the sustainability of medicinal plants. India is committed to working with WHO to strengthen Traditional Medicine Systems globally and especially in supporting fellow developing countries in promoting their own traditional medicine systems.

The Government of India has been a long-time supporter of the WHO Traditional, Complementary, and Integrative medicine unit. The unit develops key benchmark documents, standardized terminologies, and other evidence-informed technical products to enhance the acceptability and credibility of the traditional medicine systems. The new agreement, the third in a series of such agreements, exemplifies Indias commitment to both technical and financial collaboration with WHO on this important area of work.

In August 2023 in Gujarat, India, where the new WHO Global Centre for Traditional Medicine was established, the first traditional medicine global summit launched the Gujarat Declaration. The declaration paves the way for collaborative efforts in making traditional medicine an important component of national health systems.

Through this new agreement, the Government of India will continue to support WHO to develop benchmarks for training and practice in Siddha, training modules on the quality and safety of herbal medicines, the international herbal pharmacopoeia among other activities over the next five years for the advancement of traditional medicine.

Read more here:
New WHO and Ministry of AYUSH, Republic of India agreement signed to ...

Read More...

WHO Director-General discusses priorities on traditional, complementary …

December 19th, 2024 2:47 am

Civil society organizations highlight the essential role of traditional, complementary and integrative health in addressing global health challenges, and opportunities for its integration into health systems

WHO Director-General, Dr Tedros Adhanom Ghebreyesus and a group of WHO senior officials met with representatives of civil society on 3 July, to discuss their priorities on traditional, complementary and integrative medicine, in the lead up to the WHO Traditional Medicine Global Summit on 17 and 18 August 2023 in Gandhinagar, Gujarat, India.

The virtual dialogue was coordinated by the Peoples Declaration for Traditional, Complementary and Integrative Healthcare, a worldwide civil society coalition of users and practitioners of traditional, complementary and integrative healthcare. Representatives of more than 300 civil society organisations (CSOs) and over 600 people were in attendance, bringing the full force of the knowledge and expertise on traditional, complementary and integrative health (TCIH) to the forefront.

In his opening remarks, Dr Tedros said: Traditional, complementary, and integrative health is rooted in the knowledge and resources of communities. For millions of people around the world, it is their first stop for health and well-being, and an integral part of their health system. It is for precisely these reasons that dialogues with civil society organizations are so important to WHO, as we shape our guidance and policy recommendations for countries.

WHO has started the development of the new traditional medicine strategy 2025-2034 as requested by its Member States at the World Health Assembly in May 2023, during which they have also extended WHO traditional medicine strategy: 2014-2023 for another two years, until 2025. Suggestions and proposals from the civil society will contribute to this important task, and will also inform the work of the WHO Global Centre for Traditional Medicine to harness the potential of traditional medicine from across the world to improve the health of people and the planet. Furthermore, the dialogue will contribute to WHO work on traditional, complementary and integrative medicine (TCIM), which seeks to respond to requests from countries for evidence and data to inform policies and practice, global standards and regulation to ensure safety, quality, equitable access and use, and support for scientific, innovation and technological advances in traditional medicine practices.

In the dialogue, CSOs stressed that traditional and complementary systems offer a holistic understanding of the human being and its interconnectedness with the world, and as such, can contribute to a positive vision of health that integrates the physical, the mental, the spiritual, and a social well-being. Recalling the Declaration of Astana and its specific references to the role of traditional knowledge in strengthening primary health care and improving health outcomes, CSOs stressed that the key questions is how to integrate and harness TCIH in a way that makes health services more health promoting and more in balance with the health of our planet.

Patients are demanding real choice in health care with the diversity of approaches that reflect and respect the individual, their culture and their beliefs and that are fully integrated into health care. When the health care services match the desire and choice of patients, this results in better health outcomes and greater satisfaction by patients. CSOs pointed to insufficient integration of TCIH into policy, especially in providing universal health coverage, citing the example of millions of TCIH practitioners and providers in the world, who often make health care accessible and affordable to many people.

Speaking about research, CSOs stressed that although there is an established evidence base for TCIH, integration into health systems has not yet happened and lack of evidence is often cited as a barrier. CSOs supported a dramatic increase in research activity, commensurate with TCIH use, and called for a more complex research agenda, to include products, practices and practitioners.

CSO representatives also spoke about the importance of training and continuous professional development of TCIH practitioners, and about specific registration, pathway and monitoring of TCIH products to ensure safely effectiveness and accessibility for all.

TCIH - which includes the diversity and complexity of Indigenous knowledge and traditional, complementary and integrative medicine systems - shows how the philosophical differences in practicing of medicine need to be respected, a speaker said. Indigenous knowledge must be protected, and Indigenous voices included, leading the process and upholding Indigenous world view where the collective is considered more important than the individual.

WHO respects the vast Indigenous knowledge systems and traditional complementary, integrative health approaches that have evolved over centuries in a diversity of contexts, in countries across the world, said Dr Shyama Kuruvilla, WHO lead for the Global Traditional Medicine Centre and Summit. WHOs role as the lead United Nations technical agency on health is to strengthen the evidence base and the data to support safe, scalable, effective, equitable, and optimal use, and to support equitable sharing of benefits.

Dr Kim Sungchol, head of WHO Traditional, Complementary and Integrative Medicine (TCIM) Unit said: Given the importance of the person-centred and integrative healthcare, WHO has already started working on developing policy guideline on integration of TCI into healthcare delivery system. The objective is to help and support Member States in formulating policies and programmes to maximize the potential contribution of TCI to achieving the highest possible level of health and wellbeing of the people, in line with their own contexts and realities.

Some of the civil societys asks - accelerating research agenda on TCIM, integration into health systems or regulation of TCIM products - are already embedded in WHO work, both in the TCIM strategy and in our operational and work planning as we go forward, noted Dr Bruce Aylward, Assistant Director-General, Universal Health Coverage and Life Course. After COVID-19, people value their health in a different way, and this represents an opportunity.

This virtual dialogue was part of a series of CSO Dialogues with the WHO Director-General to better understand civil society priorities and strengthen the important relationship between WHO and civil society organizations. Since October 2020, when the Dialogues first started, 16 have been organized on topics ranging from gender, youth, healthy ageing, social participation and accountability, climate and health, and more.

The Dialogues are CSO led civil society sets the agenda and presents their asks to WHO. Their objectives are to find concrete proposals and solutions to support the achievement of WHOs Triple Billion targets and to accelerate the attainment of Sustainable Development Goals.

Go here to see the original:
WHO Director-General discusses priorities on traditional, complementary ...

Read More...

Global partners commit to advance evidence-based traditional …

December 19th, 2024 2:47 am

The first-ever World Health Organization (WHO) Traditional Medicine Global Summit 2023 closed on 18 August, with a strong commitment from the diverse and unique groups of partners and stakeholders to harness the potential of the evidence-based traditional, complementary and integrative medicine (TCIM) to improve progress towards universal health coverage and Sustainable Development Goals by 2030 for the health and well-being of people and the planet.

Health ministers from G20 and other countries, scientists, practitioners of traditional medicine, health workers and members of civil society from 88 countries participated in the Summit that took place in Gandhinagar, Gujarat, India on 17 and 18 August 2023.

The Summit provided a platform for all stakeholders to share their unique experiences, best practices and ideas for collaboration. It included a diverse group of Indigenous Peoples from different regions of the world (e.g. Australia, Bolivia, Brazil, Canada, Guatemala and New Zealand, among others) for whom many TCIM approaches play a fundamental role in not just health care, but also culture and livelihoods.

Preliminary findings from the WHO Global Survey on Traditional Medicine 2023 shared at the Summit indicate that around 100 countries have TCIM related national policies and strategies. In many WHO Member States, TCIM treatments are part of the essential medicine lists, essential health service packages, and are covered by national health insurance schemes. A large majority of people seek traditional, complementary and integrative medicine interventions for treatment, prevention and management of noncommunicable diseases, palliative care and rehabilitation.

Dr Bruce Aylward, Assistant Director-General, Universal Health Coverage, Life Course at WHO, highlighted the need for a stronger evidence basea WHO priorityto enable countries to develop appropriate regulations and policies around traditional, complementary, and integrative medicine.

The Summit also highlighted the important role that artificial intelligence can play to mine complex data available on traditional medicine and identify practices that show promise for further scientific evaluation. Eventually, and with ethical and equity safeguards, this evidence can translate into policies that accelerate the safe and effective use of traditional medicine into health systems.

In closing the Summit, Dr Hans Kluge, WHO Regional Director for Europe said, Together, we have gently shaken up the status quo that has, for far too long, separated different approaches to medicine and health. By taking aim at silos, we are saying we will collaborate all the more to find optimal ways to bring traditional, complementary and integrative medicine well under the umbrella of primary health care and universal health coverage. He further added, We have reiterated how crucial it is to get better evidence on the effectiveness, safety and quality of traditional and complementary medicine. That means innovative methodologies for assessing and evaluating outcomes.

Dr Shyama Kuruvilla, Senior Strategic Adviser and lead for the WHO Traditional Medicine Global Centre, who also led the organization of the Summit said, We learnt much about the existing policies, tools and practices. But it is clear we have a long journey ahead in using science to further understand, develop and deliver the full potential of TCIM approaches to improve peoples health and well-being in harmony with the planet that sustains us.

The Summits summary document included conclusions and commitments from participants on wide-ranging issues, from global policy, leadership, innovation, health workforce, data, evidence, monitoring, regulation, legal frameworks and protecting biodiversity and sustainable development.

Continued here:
Global partners commit to advance evidence-based traditional ...

Read More...

Integration of Traditional, Complementary, and Integrative Medicine …

December 19th, 2024 2:47 am

The WHO Evidence to Policy and Impact Unit (Research for Health Department) and the Evidence Unit of the WHO Global Centre for Traditional Medicine are are hosting a collaborative side event at the 2024 Prince Mahidol Award Conference (PMAC) exploring the current state of Evidence-informed policy-making (EIDM) institutionalization globally and the implications of its intersections with Traditional, Complementary, and Integrative Medicine (TCIM) in fostering inclusivity, health equity, epistemic justice, and decolonial global health governance. The side event will explore potential mechanisms (infrastructure, conditions, frameworks) for enhancing the use of evidence in global policy development toward realizing TCIMs contribution to health and wellbeing.

The use of evidence in policy and decision-making has exponentially grown, and it is now considered standard practice within health systems. However, the gap between research and practice persists. The WHO has advanced initiatives that promote the institutionalization of Evidence-informed decision/policy-making (EIDM), such theEvidence-Informed Policy Network (EVIPNet), and tools, such as theWHO checklist for supporting the routine use of evidence during the policy-making process. The checklist, currently pilot-tested to assess its validity and feasibility, highlights six domains (governance; standards and routinized processes; leadership and commitment; resources and capacity-building/strengthening; partnership, collective action, and support; and culture), and five processes of EIDM institutionalization.

TheGujarat Declarationof thefirst WHO Global Summit on Traditional Medicine(17-18 August 2023, Gandhinagar, India) articulated an action agenda including a focus on research and evidence. It proposed making appropriate use of existing and new research, evidence syntheses and knowledge translation principles and WHO initiatives. It also recommended capacity strengthening to produce, translate and use TCIM research and Indigenous knowledges and supporting the evidence-based integration of TCIM in national health policies and systems based on highest quality research.

This side event, a first step in advancing toward the evidence-related proposals of the Gujarat Declaration, seeks to assess the advances and challenges of integrating TCIM in EIDM institutionalization globally and the needed conditions to strengthen it.

Further information about the side event on the PMAC website:

https://pmac2024.com/activity/73/sidemeetingOnsite/detail

Welcoming and introduction: Tanja Kuchenmller, Unit Head, Evidence to Policy and Impact Unit, Research for Health Department, Science Division, WHO.

Session A. Overview of WHO-led EIDM initiatives, and country-level examples.

Session Chair:Laurenz Mahlanza-Langer, Executive Director, Pan-African Collective for Evidence (PACE), South Africa.

Session B. Global situation assessment / Critical analysis of TCIM-related knowledge translation and TCIM incorporation in EDIM processes.

Session Chair:Amie Steel, Associate Professor, Australian Research Consortium in Complementary and Integrative Medicine, Faculty of Health, University of Technology Sydney, Australia.

Session C. Participatory Workshop proposing next steps to address known research and practice gaps for TCIMs inclusion in EIDM

Workshop Co-Facilitators:Mukdarut Bangpan, Associate Professor in Evidence-Informed Policy and Development, University College London, United Kingdom. Amie Steel, Associate Professor, Australian Research Consortium in Complementary and Integrative Medicine, Faculty of Health, University of Technology Sydney, Australia. Daniel F. Gallego-Perez, Postdoctoral Research Fellow, University of North Carolina at Chapel Hill, USA.

Go here to see the original:
Integration of Traditional, Complementary, and Integrative Medicine ...

Read More...

Page 54«..1020..53545556..6070..»


2025 © StemCell Therapy is proudly powered by WordPress
Entries (RSS) Comments (RSS) | Violinesth by Patrick