StemCell Therapy

Dont panic. There are echoes of Dads Armys Corporal Jones as governments around the world struggle to give balanced advice to their citizens. On the one hand, the death rate from coronavirus is relatively low, more dangerous than seasonal flu, but much less deadly than other high profile outbreaks, such as Ebola, SARS and MERS. On the other, news reports are alarmist; its arrived in Wiltshire and Hampshire; a vaccine is at least a year away and if we all panic, stay at home and schools close, the economy and country will grind to a halt!

Not surprising that Mondays advice from the government was to keep calm and carry on, with a hint that shortly those with mild flu-like symptoms will be asked to stay at home and isolate themselves for a week. Meanwhile public events go ahead and schools remain open. But the British public are a fickle lot. We buy a lottery ticket when we havent got a cat in hells chance of winning; we worry about flying when were more likely to be injured driving to and from the airport while supermarkets are cleared of toilet rolls, paracetamol and hand sanitisers (soap and water is just as effective) as talismans to keep infection at bay. One interviewee told a journalist All this panic buying; its ridiculous. Weve just stocked up on a few toilet rolls and medicines

We laugh at Corporal Jones, but the thing that made Dads Army so funny, was that we were laughing at ourselves. My favourite catch phrase was Captain Mainwarings I wonder whod be the first to spot that one. after yet another blunder; I find myself using it repeatedly.

"Theres a large epidemic of coronavirus anxiety, claimed Dr William Schaffner, a leading expert on preventative medicine and infectious disease. "I think people ought to take a deep breath and spend a little more time planning what to do if the coronavirus really came into their community and they had to undergo what we call social distancing, which is separating themselves from other people. If you do this now when youre more calm, it works much better when you really have to apply it rather than planning in a more anxious moment later on.

The best medical advice is to channel our anxious energy away from loo rolls and into doing things to prevent Coronavirus spreading. Wash your hands, particularly before eating, after using public transport or when entering somewhere where there may be vulnerable people.

And begin to set out your own plans for social distancing that will reduce the risk of transmission and exposure; think where you will and wont go; whats essential in your life and what you can do without. Above all, follow Jones' advice dont panic

More:
'Don't panic Mr Mainwaring!' - Martin Field intends to keep calm and carry on during this containment phase of coronavirus - Salisbury Journal

As the new coronavirus aka COVID-19 makes its way around the planet and the United States with global infections over 100,000 and current death toll upwards 3800, health officials and politicians statewide and worldwide are declaring emergency.

Even though the common flu kills globally up to over 600,000 people annually, the super contagious coronavirus with a relatively longer latency period is somehow outshining that fact, tapping into a global fear that comes with being a new pandemic.

Both in China and Italy, millions are being quarantined, stocks markets are dipping, oil prices are falling, SouthXSouthwest canceled. Cruise ships are being held at bay. And even Senator Ted Cruz is voluntarily quarantining himself after a one-minute contact with someone who tested positive to the virus. With this global backdrop, one must wonder if we are ready for all of this.

READ MORE: Waffle House employee tests positive for Coronavirus

Juliette Keyyem, former department of Homeland security official, in her essay, The U.S. Isnt Ready for the Whats About to Happen for The Atlantic, the sub-headline reads:

Even with robust government response to the novel coronavirus, many people will be in peril. And the United States in anything but prepared.

And on the other hand, a piece in the TheConversion.com offers Ten Reasons you ought not to panic.

Whether all of this proves to be a very sad historical catastrophe or a massive overreaction, this is nevertheless a serious moment and begs the question: are Black people ready and what can we do to maximize preparedness in a world where Black life and health collectively struggles against poverty, muted healthcare access, disproportionate pre-existing issues, and history of medical racism.

Black folks have a particular history with contagion and medical racism, since the days of slavey and colonialism when the white man exposed us to all sorts of new diseases. George Washington wore dentures made from the teeth of African people, and enslaved Black women were used as human guinea pigs in gynecological experiments.

Whats more, the Tuskegee experiment is a reminder of how Black men were once part of a government study, and the victims of a racist conspiracy that left them untreated and ill with Syphilis for years. That history continues to fuel suspicions of the medical profession within the Black community.

Over a century ago, long before the current coronavirus outbreak, there was another pandemic with present-day implications. The 1918 flu epidemic killed 675,000 Americans, and between 50 and 100 million people globally, more than the total number of casualties in World War I.

READ MORE: New York State prisoners to make hand sanitizers to combat coronavirus

One of those who succumbed to the flu that year in the most curious of ironies was the grandfather of Donald Trump. One of the reasons why the flu was so deadly and spread so widely is that in America and Europe, the news media and political leaders hid the truth.

Through censorship and pressure on public health officials to lie, the public was not informed of the dangers. Woodrow Wilson, the racist president of his day who contracted the flu himself, made no public statements about the pandemic, and even enacted a law making it a crime punishable by 20 years in prison to publish information that could hurt the war effort.

Meanwhile, 1918 was the height of segregation and racial violence, when Black people were politically disenfranchised and denied health services, as white supremacy maintained theories about their biological inferiority and compromised their health, safety, education and socioeconomic status. In response to these circumstances, the black community mobilized, created institutions and hospitals and took care of their own sick people.

Theres lots of reasons for distrust around medicine for black people, and the distrust of medicine is not monolithic. There are reasons why certain kinds of people are afraid of medicine, said Dr. Steven Thrasher, assistant professor atthe Northwestern University Medill School of Journalism, Media, Integrated Marketing and Communications told theGrio.

Some are legitimate, some are not. But we have a long history of being tested on against our will, and also at the same time of being disproportionately harmed by diseases and outbreaks, and so I think its important to take this stuff seriously.

Im not aware yet of racial breakdowns of how this is playing out nationally, but certainly in terms of my own research which is primarily about HIV and police violence and gun violence, these things always disproportionately impact us. So Im particularly worried, he added.

READ MORE: LeBron refuses to play if Coronavirus keeps fans barred from arenas

Today, faced with a president who lies to your face about the gravity of the coronavirus crisis, the Black community must be vigilant. There is no telling what Trump will do to exploit the pandemic to further his white supremacist policies, lest you forget the 70,000 migrant children already locked up in ICE detention centers, including Black children from Africa, the Caribbean and Latin America.

Understanding the context of American medical racism should inspire an awareness and diligent plan of action especially when confronting a potentially deadly infectious disease such as COVID-19.

First we must all do our part in minimizing the spread of this virus. According to the World Health Organization, the advice is: we should wash our hands frequently, maintain social distance, avoid touching your face, practice good respiratory hygiene, and if you have fever, cough and hard breathing seek medical attention.

Secondly, separate facts from fiction. Just because Black folks are not the face of the coronavirus, does not mean we have special protection. The low numbers here and in Africa might be more about Black folks conservative practice of traveling outside their country and general segregated domestic travel patterns in the U.S.

In fact, BBC reportsthat Africa has more than 30 cases including countries such as Egypt, Nigeria and South Africa.

The COVID-19 gravely affects seniors and people with pre-existing conditions, such as compromised immune system, hypertension, cardiovascular diseases and diabetes. As Bloomberg news reported, top Coronavirus doctors in Wuhan, China, say high Blood pressure is major death risk. Since hypertension affects African Americans in higher numbers we must pay attention.

Contracting and falling ill to the coronavirus cannot be the way you find out you have diabetes or heart disease. This is why having access to regular medical care to know your pre-existing conditions is a smart way to protect oneself and ones community from the harm and spread of infectious diseases like the coronavirus.

So areas in our community where medical care is especially lacking, like in prisons and the homeless population, we should be intelligently worried. Dr. Thrasher also points out that, homelessness is a huge driver of incarceration, and those are two ways where the coronavirus could affect Black people very badly.

When we think of world changing disasters, we think of big things, like hurricanes, tornadoes, earthquakes or maybe even some gigantic meteorite headed our way. But history has shown us repeatedly that it is the little things, the microscopic elements that we need to really worry about.

Whether it is the black plague, influenza, polio, HIV, infectious diseases are beyond scary, testing humans capacity and social politics for survival. And while natural disasters and pandemics may create some level of surface unity around a common enemy, it also promotes systemic privileges, and exposes the most vulnerable among us, when the stakes are at their highest.

Chances are great that COVID-19 will be contained and that a vaccine will be found and the biggest casualty here will be our fleeting fear of extinction. Chances are also great that this new coronavirus will expose the best and worst of what lurks in the cytoplasm of our humanity.

And whether the source of the pandemic is lab created or natural, medical racism and mistrust are real things, and so we must be prepared, nevertheless for now and for the future. The best way to do that going forward is to advocate for the best preventative care and healthcare system access, before the cough, before the chest pain, before the hospital visit and before the grave.

Opinion articles reflect the thoughts and opinions of the authors and do not necessarily reflect the opinions of theGrio and its staff.

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Should Black America be worried about Coronavirus? - TheGrio

An electrical device the size of a watch could revolutionise the treatment of heart failure, a condition that affects nearly a million people in the UK.

The implant releases an electric current to help strengthen and even regenerate a weak or damaged heart muscle, and so improve its pumping action. This pushes more blood around the body, helping patients exercise more easily and enjoy a better quality of life.

Heart failure occurs when the muscle becomes weakened, typically as a result of heart disease, high blood pressure, irregular heart rhythms or the damage caused by a heart attack.

Symptoms include breathlessness, feeling permanently tired and having swollen ankles these worsen over time.

A recent study from Keele University showed that people who have heart failure have a higher risk of premature death than those with common types of cancer.

Treatment involves managing the symptoms there is currently no cure and ranges from drugs that widen blood vessels to improve blood flow, to surgery to bypass clogged arteries, and heart transplants.

Although transplants can be highly effective, there is a shortage of donor organs.

The new device may help those who dont respond to medication and could delay the need for a heart transplant, or avoid the need altogether.

It consists of a small implanted generator, which is attached to two electrodes.

One of the electrodes, in the form of a mesh patch, is attached to the outside of the heart muscle, while the other sits in the left ventricle, one of two large chambers towards the bottom of the heart that collect and expel blood.

The implant is inserted under general anaesthetic in a procedure that involves only two small incisions in the chest. It takes around an hour.

Research in animals has already shown that improving the strength of the hearts contractions can cause muscle cells to regenerate and work more effectively.

Developed by Germany-based Berlin Heals, the new device has been successfully used in humans for the first time in hospitals in Austria and Serbia. After three months, the first patient treated with the device is already showing signs of regeneration.

Dr Punit Ramrakha, a consultant cardiologist at Hammersmith Hospital, says the device may be another option for patients with advanced heart failure who havent responded to conventional therapy.

But he adds: The risks of the procedure which requires a general anaesthetic may well be outweighed by the clinical benefits, and we look forward to seeing the results of the clinical trials.

The idea is that the battery-powered device, which is about the size of a mobile phone, stimulates nerve fibres, leading to increased blood flow.

Doctors at the Chang Gung Memorial Hospital in Taiwan plan to test it.

The best time to take your medication. This week: Diuretics

Used to treat heart failure and high blood pressure, diuretics or water tablets increase the amount of salt and water that comes out of your body in your urine.

Too much salt in the body can cause extra fluid to build up in the blood vessels, raising blood pressure. Diuretics lower blood pressure by flushing salt out of the body, taking unwanted extra fluid with it.

They also cause the walls of the blood vessels to relax and widen, making it easier for blood to flow and so reducing blood pressure.

The downside of the medication is more trips to the toilet.

Doctors advise the best time to take the pills is in the morning. The effects last for six hours. If you need a second dose, take it by mid-afternoon to avoid extra loo trips at night.

Altruist Anti-Redness and Pigmentation Cream has SPF50 in it and also works as a concealer, so its ideal for those with rosacea or other sensitive skin conditions (12.50, 50ml, amazon.co.uk).

How parenthood affects your health. This week: Weight gain

Having children is linked to a long-term increased risk of obesity in women.

A 2005 study of more than 2,000 women, published in the journal Preventative Medicine, found that for each child a woman has, her risk of obesity increases by 7 per cent.

After taking into account factors such as age, marital status and physical activity levels, researchers found that rates of obesity were significantly higher among women who had more children.

Our results suggest pregnant women, especially those with several children, are an important high-risk population for obesity in later life, they said.

The weight gain may be caused by insulin resistance, which is greater in women with more children, as pregnancy can alter glucose metabolism. Another cause could be stress.

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Implant that gives failing hearts a boost! - Infosurhoy

Biotechnology is not only an exciting career that covers a broad range of career fields engaged in advancing medical technologyits also a quickly growing job choice. In fact, according to Grand View Research, the biotechnology market is expected to reach $727.1 billion by 2025.

The skills and experience that students can gain from biotechnology graduate programs are crucial to excelling in this rapidly evolving field. But not all biotechnology graduate programs are created the samewhile its essential to master the curriculum, some lessons are better grasped through hands-on experience and training.

This is what sets Azusa Pacific Universitys M.S. in Biotechnology apart. The program focuses on internships and masters projects with pharmaceutical, biopharmaceutical, and medical device companies.

Academic laboratories are crucial and, at APU, courses are taught by industry professionals. But with the biotech industry changing continually, it can be a challenge for students to experience current technical advances unless theyre directly in the field. APUs program incorporates onsite internship experiences to ensure every program graduate is well-versed in the industry landscape.

Almost half of the top biotech companies are headquartered in California, in cities likes San Francisco and Los Angeles. APU is just 26 miles from L.A., which gives biotech students many opportunities to work alongside top professionals in the field. Students collaborate with companies like Gilead Sciences, Amgen, and Medtronic, where theyre able to observe state-of-the-art technical practices currently used in the industry. David Dyer, Ph.D., executive director of APUs M.S. in Biotechnology program, explained that this experience also allows students to understand aspects of a companys work environment, including communication, team function, leadership, and management style.

The goal is for grad students to obtain the skills needed to go from classroom to career field seamlessly.

A second reason the M.S. in Biotechnology program emphasizes in-person work with companies is that the company can get a long look at the student as a potential future hire, said Dyer. Companies can also place students on projects where they may require additional assistance.

Justin Hoang, a current biotech student, said that his internship with Grifols was a valuable learning experience. I learned how to operate new systems and software that pertained to the career I wish to pursue after graduation, he noted.

Graduates of APUs biotech program receive a head start on their rsums as well, as theyre able to list their experience with widely recognizable companies. The program prepares individuals for a variety of biotech careers, including those in epidemiology, genetic counseling, and microbiology.

APU alum Najeh Salamah enrolled in the M.S. in Biotechnology program after being away from school for a while. Salamah said, The well-rounded program sets you up for success, and you dont have to be a traditional biology/chemistry major.

Students of the program are required to complete 900 hours of onsite training, so every graduate will be adequately exposed to corporate practice and culturebut you wont be alone throughout the program. Salamah said that the programs faculty, counselors, and director are like family and work to guide their classes to have fruitful and compelling interaction. The faculty want their students to succeed and work to make everyone feel welcome.

Are you interested in becoming part of the biotech family at Azusa Pacific University and working toward your M.S. in Biotechnology? Learn more about the programs associated coursework and academic requirements.

Posted: March 10, 2020

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The Benefit of Hands-On Experience in Biotechnology Graduate Programs - Azusa Pacific University

Dublin, March 10, 2020 (GLOBE NEWSWIRE) -- The "Animal Biotechnology - Technologies, Markets and Companies" report from Jain PharmaBiotech has been added to ResearchAndMarkets.com's offering.

Share of biotechnology-based products and services in 2018 is analyzed and the market is projected to 2028. The text is supplemented with 36 tables and 6 figures. Selected 260 references from the literature are appended.

Approximately 124 companies have been identified to be involved in animal biotechnology and are profiled in the report. These are a mix of animal healthcare companies and biotechnology companies. Top companies in this area are identified and ranked. Information is given about the research activities of 11 veterinary and livestock research institutes. Important 110 collaborations in this area are shown.

The report contains information on the following:

This report describes and evaluates animal biotechnology and its application in veterinary medicine and pharmaceuticals as well as improvement in food production. Knowledge of animal genetics is important in the application of biotechnology to manage genetic disorders and improve animal breeding. Genomics, proteomics and bioinformatics are also being applied to animal biotechnology.

Transgenic technologies are used for improving milk production and the meat in farm animals as well as for creating models of human diseases. Transgenic animals are used for the production of proteins for human medical use. Biotechnology is applied to facilitate xenotransplantation from animals to humans. Genetic engineering is done in farm animals and nuclear transfer technology has become an important and preferred method for cloning animals. There is a discussion of in vitro meat production by culture.

Biotechnology has potential applications in the management of several animal diseases such as foot-and-mouth disease, classical swine fever, avian flu and bovine spongiform encephalopathy. The most important biotechnology-based products consist of vaccines, particularly genetically engineered or DNA vaccines. Gene therapy for diseases of pet animals is a fast developing area because many of the technologies used in clinical trials humans were developed in animals and many of the diseases of cats and dogs are similar to those in humans.RNA interference technology is now being applied for research in veterinary medicine

Molecular diagnosis is assuming an important place in veterinary practice. Polymerase chain reaction and its modifications are considered to be important. Fluorescent in situ hybridization and enzyme-linked immunosorbent assays are also widely used. Newer biochip-based technologies and biosensors are also finding their way in veterinary diagnostics.

Biotechnology products are approved by the Center for Veterinary Medicine of the FDA. Regulatory issues relevant to animal biotechnology are described.

List of Topics Covered

Executive Summary1. Introduction to Animal Biotechnology2. Application of Biotechnology in Animals3. A Biotechnology Perspective of Animals Diseases4. Molecular Diagnostics in Animals5. Biotechnology-based Veterinary Medicine6. Research in Animal Biotechnology7. Animal Biotechnology Markets8. Regulatory Issues9. Companies Involved in Animal Biotechnology10. References

For more information about this report visit https://www.researchandmarkets.com/r/qbm3p5

Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research.

CONTACT: ResearchAndMarkets.comLaura Wood, Senior Press Managerpress@researchandmarkets.comFor E.S.T Office Hours Call 1-917-300-0470For U.S./CAN Toll Free Call 1-800-526-8630For GMT Office Hours Call +353-1-416-8900

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Global Animal Biotechnology Industry Insights, 2018-2028 Featuring Profiles of ~124 Players and 110 Collaborations - Yahoo Finance

SAN FRANCISCO, March 12, 2020 (GLOBE NEWSWIRE) -- Vir Biotechnology, Inc.(Nasdaq: VIR) today announced that it has signed a letter of intent with Biogen Inc. (Nasdaq: BIIB) for the development and clinical manufacturing of human monoclonal antibodies for the potential treatment of COVID-19, the disease caused by the SARS-CoV-2 virus. Because of the urgency of the situation, the companies have begun work while a Clinical Development and Manufacturing Agreement is being negotiated. Subject to the completion of a definitive agreement, Biogen would continue cell line development, process development, and clinical manufacturing activities in order to advance the development of Virs proprietary antibodies.

These exceptional circumstances presented by the threat of COVID-19 require that we work with great urgency in the interest of the public good, said George Scangos, Ph.D., CEO, Vir. Biogen is one of the global leaders in cell line and process development for advanced biologics; tapping into their capabilities will provide us with a U.S. base for supply and manufacture of antibody therapies.

Vir has identified a number of monoclonal antibodies that bind to SARS-CoV-2, which were isolated from individuals who had survived a SARS (Severe Acute Respiratory Syndrome) infection. The company is conducting research to determine if its antibodies, or additional antibodies that it may be able to identify, can be effective as treatment and/or prophylaxis against SARS-CoV-2.

About Virs Antibody Platform

Vir has a robust method for capitalizing on unusually successful immune responses naturally occurring in people who are protected from, or have recovered from, infectious diseases. The platform is used to identify rare antibodies from survivors that have the potential to treat and prevent rapidly evolving and/or previously untreatable pathogens via direct pathogen neutralization and immune system stimulation. Vir engineers the fully human antibodies that it discovers to enhance their therapeutic potential. This platform has been used to identify and develop antibodies for pathogens including Ebola (mAb114, currently in use in theDemocratic Republic of Congo), hepatitis B virus, influenza A, malaria, and others.

AboutVir Biotechnology

Vir Biotechnology is a clinical-stage immunology company focused on combining immunologic insights with cutting-edge technologies to treat and prevent serious infectious diseases. Vir has assembled four technology platforms that are designed to stimulate and enhance the immune system by exploiting critical observations of natural immune processes. Its current development pipeline consists of five product candidates targeting hepatitis B virus, influenza A, human immunodeficiency virus, and tuberculosis. For more information, please visit http://www.vir.bio.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as may, will, expect, plan, anticipate, estimate, intend, potential and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) are intended to identify forward-looking statements. These forward-looking statements are based on Virs expectations and assumptions as of the date of this press release. Each of these forward-looking statements involves risks and uncertainties. Actual results may differ materially from these forward-looking statements. Forward-looking statements contained in this press release include statements regarding the companys efforts to neutralize the SARS-CoV-2 virus and identify additional potential therapies for SARS-CoV-2, its ability to address the emerging public health epidemic, and its ability to enter into an agreement with Biogen, and its ability to secure a U.S. base for supply and manufacture of antibody therapies. Many factors may cause differences between current expectations and actual results including unexpected safety or efficacy data observed during preclinical or clinical studies, challenges in neutralizing SARS-CoV-2, difficulty in reaching a definitive agreement with Biogen, challenges of collaborating with other companies or government agencies, and challenges in accessing manufacturing capacity. Other factors that may cause actual results to differ from those expressed or implied in the forward-looking statements in this press release are discussed in Virs filings with theU.S. Securities and Exchange Commission, including the section titled Risk Factors contained therein. Except as required by law, Vir assumes no obligation to update any forward-looking statements contained herein to reflect any change in expectations, even as new information becomes available.

Contact:Vir Biotechnology, Inc.Investors Neera Ravindran, MDHead of Investor Relations & Strategic Communications nravindran@vir.bio+1-415-506-5256

Media Lindy Devereux Scient PR lindy@scientpr.com +1-646-515-5730

Original post:
Vir Biotechnology Announces Intent to Collaborate with Biogen on Manufacturing of Antibodies to Potentially Treat COVID-19 - GlobeNewswire

New data prove that propionic acid modulates the intestine-mediated immune regulation in people with multiple sclerosis (MS).

In Cell the team headed by Aiden Haghikia from University Bochum demonstrated that the administration of propionic acid (PA) in addition to MS standard therapy reduced the relapse rate and the risk of disability increase in the long term. Furthermore, MRI studies indicate that propionic acid may reduce brain shrinkage of patients with Multiple sclerosis (MS), which is regarded as a measure for neuronal cell death.

Haghikia et al. demonstrated that

PA is reduced in MS patients, particularly early after disease manifestation; PA reduction is associated with an altered gut microbiome composition; after 14days of PA supplementation, Treg cell/TH17 imbalance was restored; longitudinal PA supplementation might have clinical implications.

The reseach team together with co-working groups at MDC Berlin and University of Halle-Wittenberg demonstrated that the microbiome composition is altered in MS patients. In addition, for the first time they were able to show a deficiency of propionic acid in the stool and serum of MS patients, which was most pronounced in the earliest phase of the disease. Propionic acid is an EFSA-approved antibacterial food supplement.

"Intestinal bacteria can directly and indirectly influence anatomically distant structures such as the brain," explained study head Haghikia, who together with Flexopharm Brain GMBH & Co. KG holds a patent on the invention. The company markets a related food supplement. "The intestinal microbiome thus corresponds to an independent endocrine organ that is in contact with the environment."

In the current study, the scientists transfered results previously obtained in cell culture and disease models co-developed witha group from Bar-Ilan University in Israel to MS patients: short-chain fatty acids such as propionic acid or its salt propionate led to the increased formation and increased function of T regulatory cells (Tregs) of the immune system. "These cells stop excessive inflammatory reactions and reduce auto-immune cells in the context of autoimmune diseases such as MS," said co-author Ralf Gold, Director of Neurology at St. Josef Hospital. The increase in Treg function is due to improved energy utilization through an altered function of the mitochondria.

However, the short-chain fatty acids represent only a fraction of the metabolic products of intestinal bacteria. "Further research into this largely unknown organ and the knowledge gained from it will make it possible to develop further innovative dietary measures to complement the known therapeutics in the future," commented Haghikia.

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Nutrition influences the course of MS - European Biotechnology

Here's a roundup of top developments in the biotech space over the last 24 hours:

(Biotech stocks that hit 52-week highsMarch 9.)

(Biotech stocks that hit 52-week lows March 9.)

See also:Attention Biotech Investors: Mark Your Calendar For These March PDUFA Dates

Mesoblast limited (NASDAQ: MESO) said it plans to evaluate its allogenic mesenchymal stem cell product candidate remestemcel-L in patients with acute respiratory distress syndrome caused by COVID-19 in the U.S., Australia, China and Europe.

The company said it is in active discussions with various government and regulatory authorities, medical institutions and pharma companies.

In premarket trading Tuesday, the shares were surging 28.35% to $7.90.

Emergent Biosolutions Inc (NYSE: EBS) said it has entered into an agreement with Novavax, Inc. (NASDAQ: NVAX), under which the former will use its molecule-to-market contract development and manufacturing service to support bringing intothe latter's vaccine candidate to protect against COVID-19 into the clinic.

Emergent will produce the COVID-19 experimental vaccine candidate developed using Novavax's proprietary recombinant protein nanoparticle technology platform. Emergent said it has initiated work and anticipatescommencement of a Phase 1 study within the next four months.

Separately, Novavax said the Coalition for Epidemic Preparedness awarded it an initial funding of $4 million to support its COVID-19 vaccine program.

In premarket trading Tuesday, Emergent shares were adding 0.95% to $53.02 and Novavax shares were surging up 24.35% to $12.46.

GENMAB A/S/S ADR (NASDAQ: GMAB) announced the appointment of Anthony Mancini as EVP and COOeffective March 23. Mancini's rolecalls for himto oversee the company's commercial, corporate development, business development and information technology functions.

Ophthalmic medtech and pharma company Glaukos is set to join the S&P SmallCap 600 Index, effective prior to the open of trading March 13, replacing AK Steel Holding Corporation (NYSE: AKS), which has agreed to be acquired by Cleveland-Cliffs Inc (NYSE: CLF).

Glaukos shares were trading 7.5% higher at $38.49 in the premarket session.

MediciNova, Inc. (NASDAQ: MNOV) said it plans to initiate the development of MN-166 for severe pneumonia and acute respiratory distress syndrome following positive results in a recent preclinical study in an animal model. The animal study showed treatment with the investigational candidate reversed histological changes, including inflammation, hemorrhage, alveolar congestion and alveolar edema.

Medical Resources Acquisition said on Feb. 25 it offered Rockwell Medical Inc (NASDAQ: RMTI) $15 million in equity investment for three board seatscurrently held by John Cooper, Mark Ravich and Lisa Colleran.

The investment firm said Rockwell's board hasfailed to provide appropriate governance, resulting in reckless spending, acash deficiency and a lack of operational controls that have impacted stock performance.

Rockwell acknowledged receiving an email from Medical Resources Acquisition in a press release.

"The Board of Directors is in the process of reviewing the materials submitted by MRAG. Stockholders do not need to take any action at this time," the company said.

The stock was trading 9.37% higher at $3.50 in Tuesday's premarket session.

Acceleron Pharma Inc (NASDAQ: XLRN) saidtreatment with ACE-083 in patients with Charcot-Marie-Tooth disease did not demonstrate functional improvement in aPhase 2 trial.

The companysaid it is discontinuing the development of ACE-083.

Organogenesis Holdings Inc's (NASDAQ: ORGO) fourth-quarter revenues climbed 17% to $74.6 million. The net loss per share narrowed from 12 cents to 4 cents. For 2020, the company guided to revenues of $273 million to $277 million. The results as well as the guidance were above consensus.

The stock jumped 14.56% to $3.54 in after-hours trading.

Aduro BioTech Inc (NASDAQ: ADRO) said its fourth-quarter revenues increased from $2.8 million in 2018 to $3.6 million in 2019. The loss per share narrowed from 33 cents to 24 cents, while analysts expected a narrower loss of 21 cents per share.

The stock slipped 4.89% to $2.92 in after-hours trading.

Assertio Therapeutics Inc (NASDAQ: ASRT) reported fourth-quarter revenues of $59.23 million and a loss of $2.65 per share. In the year-ago quarter, the company reported revenues of $42.6million and a loss of 38 cents per share. On a non-GAAP basis, the company reported a loss of 14 cents per share for the recent quarter compared to expectations for a profit of 14 cents per share.

The stock fell 11.21% to 95 cents in after-hours trading.

The FDA is set to rule on Bristol-Myers Squibb Co's (NYSE: BMY) sBLA for Opdivo + Yervoy as treatment option for patients with advanced hepatocellular carcinoma who werepreviously treated with Bayer AG (OTC: BAYRY) and Onyx Pharma's Nexavar.

Related Link: The Week Ahead In Biotech (March 8-14): Bristol-Myers Awaits FDA Nod For Liver Cancer Combo Therapy, Earnings Flow Continues

2020 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

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The Daily Biotech Pulse: Mesoblast To Test Candidate On Coronavirus Symptoms, Proxy Battle Ahead For Rockwell Medical, Glaukos to Join S&P SmallCap...

Biotech stocks rebounded in the week ended March 6, recovering from the previous week's steep sell-off.

The week was light on news flow, barring some smid-cap earnings andCOVID-19 treatment and vaccine news.

The following arekey catalysts in the unfolding week that a biotech investor should stay tuned to.

Barclays Global Healthcare Conference: March 10-12 in Miami, Florida.American Academy of Allergy Asthma and Immunology, or AAAAI, Annual Meeting: March 13-16 in Philadelphia, Pennsylvania.

The FDA is set to rule on Bristol-Myers Squibb Co's (NYSE: BMY) sBLA for Opdivo + Yervoy as a treatment option for patients with advanced hepatocellular carcinoma who were previously treated with Bayer AG (OTC: BAYRY) and Onyx Pharma's Nexavar. The PDUFA date has been set for Tuesday.

Blueprint Medicines Corp (NASDAQ: BPMC) is scheduled to present at the AAAAI annual meeting with Phase 2 data for Avapritinib, which is being evaluated for treating indolent and smoldering systemic mastocytosis.

See also: Attention Biotech Investors: Mark Your Calendar For These March PDUFA Dates

Monday

Tuesday

Wednesday

Friday

Imara, a biopharma company that is developing therapies for rare hemoglobinopathies, has filed to offer 4.45 million shares in an IPO, to be priced between $16 and $18. The company seeks to list its shares on the Nasdaq under the ticker symbol "IMRA."

Revolution Medicines Inc (NASDAQ: RVMD)

Related Link: How The COVID-19 Outbreak Is Benefiting Biotech Investors

2020 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

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The Week Ahead In Biotech (March 8-14): Bristol-Myers Awaits FDA Nod For Liver Cancer Combo Therapy, Earnings Flow Continues - Benzinga

SOUTH SAN FRANCISCO, Calif., March 11, 2020 (GLOBE NEWSWIRE) -- UNITY Biotechnology, Inc. (UNITY) [NASDAQ:UBX], a biotechnology company developing therapeutics to extend healthspan by slowing, halting or reversing diseases of aging, today reported financial results for the fourth quarter and full year ended December 31, 2019. Unity issued a press release providing pipeline and business updates on February 25, 2020.

Fourth Quarter and Full Year 2019 Financial Results

Cash, cash equivalents and investments totaled $125.0 million as of December 31, 2019 compared with $171.1 million as of December 31, 2018.

Operating loss for the twelve months ended December 31, 2019 was $89.7 million compared to $79.5 million for the twelve months ended December 31, 2018. Cash used in operations during the year ended 2019 was $72.4 million compared to $56.6 million for the year ended 2018. Total operating loss for the three months ended December 31, 2019 was $23.1 million compared to $22.8 million for the fourth quarter of 2018. Cash used in operations during the fourth quarter of 2019 was $15.7 million compared to $12.8 million for the fourth quarter of 2018.

Research and development expenses were $71.0 million for the year ended December 31, 2019 compared to $58.9 million for the year ended December 31, 2018. The increase of $12.1 million was primarily due to a net increase of $2.3 million for personnel-related expenses, which was partially offset by a decrease of $1.1 million related to non-cash stock compensation expense,$6.7 million for outside research and development activities and $3.1 million in lab and facilities-related costs. Research and development expenses were $18.2 million for the three months ended December 31, 2019 compared to $16.3 million for the three months ended December 31, 2018. The increaseof $1.9 million was primarily due to $0.5 million for personnel-related expenses and $1.1 million for outside research and development activities.

General and administrative expenses were $20.0 million for the year ended December 31, 2019 compared to $16.0 million for the year ended December 31, 2018. The increase of $4.0 million was primarily due to an increase of $3.4 million for personnel-related expenses, of which $2.5 millionwas related to non-cash stock compensation expense,and $0.6 million in insurance-related expenses, partially offset by $0.5 million decrease in professional fees. General and administrative expenses were $4.9 million for the three months ended December 31, 2019 compared to $4.3 million for the three months ended December 31, 2018.The $0.6 million increase was primarily due to personnel-related costs, primarily attributable to non-cash stock-based compensation expense.

About UNITYUNITY is developing therapeutics to extend healthspan with an initial focus on cellular senescence. UNITY believes that the accumulation of senescent cells is a fundamental mechanism of aging and a driver of many common age-related diseases. Cellular senescence is a natural biological state in which a cell permanently halts division. As senescent cells accumulate with age, they begin secreting inflammatory factors, proteases, fibrotic factors, and growth factors, that disturb the tissue micro-environment. This collection of secreted proteins is referred to as the Senescence Associated Secretory Phenotype, or SASP. UNITY is developing senolytic medicines to eliminate senescent cells and thereby stop the production of the SASP, which UNITY believes addresses a root cause of age-related diseases. By stopping the production of the SASP at it source, UNITY believes senolytic medicines could slow, halt, or reverse diseases such as osteoarthritis and age-related eye diseases.More information is available atwww.unitybiotechnology.comor follow us onTwitter.

Forward-Looking StatementsThis press release contains forward-looking statements including statements related to the potential for UNITY to develop therapeutics to extend healthspan. These statements involve substantial known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. We may not actually achieve the plans, intentions or expectations disclosed in our forward-looking statements, and you should not place undue reliance on our forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements we make. The forward-looking statements in this press release represent our views as of the date of this release. We anticipate that subsequent events and developments will cause our views to change. However, while we may elect to update these forward-looking statements at some point in the future, we have no current intention of doing so except to the extent required by applicable law. You should, therefore, not rely on these forward-looking statements as representing our views as of any date subsequent to the date of this release. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to the business of the Company in general, see UNITYs most recently filed Quarterly Report on Form 10-Q for the quarter ended September 30, 2019, filed with the Securities and Exchange Commission on November 6, 2019, as well as other documents that may be filed by UNITY from time to time with the Securities and Exchange Commission.

Investors Endurance AdvisorsPeter Rahmerprahmer@enduranceadvisors.com

Media Canale CommunicationsJason Sparkjason@canalecomm.com

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UNITY Biotechnology, Inc. Reports Fourth Quarter and Full Year 2019 Financial Results - GlobeNewswire

CAMBRIDGE, Mass., March 12, 2020 /PRNewswire/ -- Kymera Therapeutics Inc., a biotechnology company pioneering targeted protein degradation to invent breakthrough protein degrader medicines for patients, today announced the closing of a $102 million Series C financing. The round was led by Biotechnology Value Fund (BVF) and Redmile Group with participation from Wellington Management Company, Bain Capital Life Sciences, funds managed by Janus Henderson Investors and BlackRock, Rock Springs Capital and a large US-based, healthcare-focused fund. Existing investors also participated in the round.

Kymera also received a strategic investment from The Leukemia & Lymphoma Society's Therapy Acceleration Program (LLS TAP) directed toward advancing the company's work to treat blood-based cancers.

"We are very excited to be joined by a top-tier group of investors as we continue on our path to become a fully integrated biotech company," said Nello Mainolfi, PhD, co-founder, President and CEO of Kymera Therapeutics. "We are well capitalized to advance up to three programs to the clinic by next year, while we continue to enhance our best-in-class platform to unlock new biology and invent new medicines."

Kymera's Pegasus targeted protein degradation platform harnesses the body's natural protein recycling machinery to degrade disease-causing proteins, with a focus on un-drugged nodes in validated pathways currently inaccessible with conventional therapeutics.

Kymera's lead program targets IRAK4, a protein known to play a significant role in inflammation mediated by toll-like and IL-1 receptors. Kymera is planning to advance its IRAK4 degrader program in a variety of autoinflammatory and autoimmune diseases, as well as in precision-medicine targeted oncology indications. The company is also developing novel protein degrader therapies to target STAT3, an un-drugged oncogenic transcription factor as well as a driver of inflammation and fibrosis, in a range of cancers and chronic diseases.

"Targeted protein degradation is one of the most promising new therapeutic modalities, with the potential to transform medicine as we know it. Kymera is leading the way with an incredible team, a sophisticated drug discovery platform and important new protein degrader therapies designed to address the most elusive drug targets" said Bruce Booth, DPhil, co-founder, Chairman of the Board of Kymera Therapeutics and partner at Atlas Venture.

About Kymera Therapeutics

Kymera Therapeutics is a biotechnology company pioneering a transformative new approach to treating previously untreatable diseases. The company is advancing the field of targeted protein degradation, accessing the body's innate protein recycling machinery to degrade dysregulated, disease-causing proteins. Powered by Pegasus, a game-changing integrated degradation platform, Kymera is accelerating drug discovery with an unmatched ability to target and degrade the most intractable of proteins, and advance new treatment options for patients. For more information visit, http://www.kymeratx.com.

About Pegasus

Pegasus is Kymera Therapeutics' proprietary protein degradation platform, created by its team of experienced drug hunters to improve the effectiveness of targeted protein degradation and generate a pipeline of novel therapeutics for previously undruggable diseases. The platform consists of informatics driven target identification, novel E3 ligases, proprietary ternary complex predictive modeling capabilities, and degradation tools.

About The Leukemia & Lymphoma Society and Therapy Acceleration Program (TAP)

The Leukemia & Lymphoma Society (LLS) is a global leader in the fight against cancer. The LLS mission: cure leukemia, lymphoma, multiple myeloma, and improve the quality of life of patients and their families. LLS TAP is a strategic initiative that builds business alliances and collaborations with biotechnology companies and academic researchers to identify potential breakthrough therapies with the potential to change the standard of care. LLS TAP funds late stage pre-clinical studies, and proof of concept or registrational clinical trials to help advance these more quickly along the drug development and approval pathway. To learn more, visit http://www.LLS.org.

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Kymera Therapeutics Announces $102 Million Series C Financing to Advance its Protein Degrader Pipeline and Platform - BioSpace

DEAR DR. ROACH: Im a 63-year-old male diagnosed with chronic myelogenous leukemia, Type 2 diabetes and coronary heart disease. I am 5 feet, 11 inches and weigh 240 pounds. I have two stents and take Sprycel for the CML. My levels are good, and the coronary disease is under control.

For a few years Ive had what feels like cotton balls under the skin in the area of the balls of my feet. Now it feels like its migrating to the arch. While not too uncomfortable, it is almost impossible to walk barefooted. Some type of foot covering is needed to keep from noticing the feeling. My doctor says its the diabetes, and to lose weight or see a podiatrist. Other than losing the weight, do you have any opinion about this? N.M.

ANSWER: Cotton-ball sensation is one way that many people describe the beginning of neuropathy, a general term for a variety of different conditions that affect the nerves of the body.

In a person with cancer (like CML, chronic myelogenous leukemia, a cancer of the bone marrow) and a new symptom, it is always wise to consider whether it could be due to the cancer, the treatment for the cancer or from something else. In your case, usually CML is not associated with neuropathy. However, the medicine you are taking, dasatinib (Sprycel), has been associated with a severe kind of reversible neuropathy. I read the case reports of this condition carefully, and I doubt that is what is going on with you, as the symptoms you have are different from those reported.

People with longstanding diabetes frequently develop a particular disease of the nerves, diabetic neuropathy. This almost always begins with sensation changes in the feet. I agree with your doctor that diabetes is the most likely cause.

Seeing a podiatrist is absolutely a good idea. He or she can test you for this condition (usually a careful physical exam will make the diagnosis), in addition to looking carefully for any early signs or risk factors for injury or infection. You also should learn how to do a daily inspection of your feet and recognize the signs, so you can get to medical attention promptly should any damage to your feet occur. The podiatrist will make sure you have appropriate footwear.

Many people with diabetes benefit from weight loss, but the important thing is to be sure your diabetes is under good control. This is achieved through good diet, regular exercise and medication, if needed, in addition to weight loss in people who are overweight.

DEAR DR. ROACH: Due to cancer, my prostate was removed about seven years ago. My PSA reading has increased since 2012 from 0.09 to 0.304. Should I be concerned? I am 78 years old and in relatively good health. B.D.

ANSWER: PSA readings can go up and down, but a threefold increase could mean that the cancer is coming back, and you should see the specialist taking care of your prostate cancer to discuss getting additional testing.

Not having disease for seven years after treatment is a good sign, but the PSA test is pretty specific for cancer recurrence if two separate readings are above 0.2. You may need additional therapy, but only further investigation will show how concerned you need to be.

Dr. Roach regrets that he is unable to answer individual questions, but will incorporate them in the column whenever possible. Readers may email questions to ToYourGoodHealth@med.cornell.edu.

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'Cotton ball' sensation is a sign of neuropathy - Coastal Courier

Los Angeles, United State The report titled Global Neuropathy Pain Treatment Market Research Report 2020 is one of the most comprehensive and important additions to QY Researchs archive of market research studies. It offers detailed research and analysis of key aspects of the global Neuropathy Pain Treatment market. The market analysts authoring this report have provided in-depth information on leading growth drivers, restraints, challenges, trends, and opportunities to offer a complete analysis of the global Neuropathy Pain Treatment market. Market participants can use the analysis on market dynamics to plan effective growth strategies and prepare for future challenges beforehand. Each trend of the global Neuropathy Pain Treatment market is carefully analyzed and researched about by the market analysts.

Global Neuropathy Pain Treatment Market is valued at USD XX million in 2019 and is projected to reach USD XX million by the end of 2025, growing at a CAGR of XX% during the period 2019 to 2025.

Top Key Players of the Global Neuropathy Pain Treatment Market: Pfizer, Depomed, Eli Lilly, Endo, Grnenthal Group, Arbor Pharmaceuticals,

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* Top Key Company Profiles.

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Global Neuropathy Pain Treatment Market Segmentation By Product:

Calcium Channel Alpha 2-delta LigandsSerotonin-norepinephrine Reuptake InhibitorsOthers

Global Neuropathy Pain Treatment Market Segmentation By Application:

Retail PharmaciesHospitalsOthers

In terms of region, this research report covers almost all the major regions across the globe such as North America, Europe, South America, the Middle East, and Africa and the Asia Pacific. Europe and North America regions are anticipated to show an upward growth in the years to come. While Neuropathy Pain Treatment Market in Asia Pacific regions is likely to show remarkable growth during the forecasted period. Cutting edge technology and innovations are the most important traits of the North America region and thats the reason most of the time the US dominates the global markets. Neuropathy Pain Treatment Market in South, America region is also expected to grow in near future.

Key questions answered in the report

* What will be the market size in terms of value and volume in the next five years?

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* Data triangulation and market breakdown

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We provide detailed product mapping and analysis of various market scenarios. Our analysts are experts in providing in-depth analysis and breakdown of the business of key market leaders. We keep a close eye on recent developments and follow latest company news related to different players operating in the global Neuropathy Pain Treatment market. This helps us to deeply analyze companies as well as the competitive landscape. Our vendor landscape analysis offers a complete study that will help you to stay on top of the competition.

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We established as a research firm in 2007 and have since grown into a trusted brand amongst many industries. Over the years, we have consistently worked toward delivering high-quality customized solutions for wide range of clients ranging from ICT to healthcare industries. With over 50,000 satisfied clients, spread over 80 countries, we have sincerely strived to deliver the best analytics through exhaustive research methodologies.

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Neuropathy Pain Treatment Market by Companies, Regions, Type and Application 2026| Pfizer, Depomed, Eli Lilly - Weekly Wall

For breast cancer patients, the adverse effects of the cancer and its treatments do not cease when the disease leaves the body, and well-being remains affected. A new study found that older breast cancer survivors live with a higher level of actionable symptoms and greater loss of wellbeing over time compared to patients without cancer.

According to the authors, they undertook the study because there is little research regarding the long-term symptom burden carried by this population, as well as how this burden affects overall well-being and if lifestyle interventions influence it.

The study focused on breast cancer survivors aged 60 years with newly diagnosed, nonmetastatic breast cancer, who were compared to noncancer controls. Recruitment took place between August 2010 and June 2016. The following parameters were used to measure symptom burden: pain (yes or no), fatigue (on the Functional Assessment of Cancer Therapy [FACT]Fatigue scale), cognitive problems (on the FACTCognitive scale), sleep problems (yes or no), depression (on the Center for Epidemiologic Studies Depression scale), anxiety (on the StateTrait Anxiety Inventory), and cardiac problems and neuropathy (yes or no). A 100-point FACT-General scale was used to determine well-being. Lifestyle was assessed by factors including smoking, alcohol use, body mass index, physical activity, and leisure activities. Correlations were analyzed between treatment group (chemotherapy with or without hormone therapy, hormone therapy only, and controls) and symptom burden, lifestyle, and covariates; further analyses assessed how fluctuations in symptom burden and lifestyle affected function.

Symptoms were high at baseline across the whole cohort. The most significant differences between the cancer survivors and controls were observed in cognitive problems, sleep problems, anxiety, and neuropathy. In adjusted analyses, survivors who had undergone chemotherapy had the highest burden score, followed by those who had received hormone therapy, compared to controls (P<0.001). Factors that influenced the burden score were physical, emotional, and mental well-being; survivors with lower burden scores, compared to those with higher burden scores, had 12.4-point higher physical well-being scores. Lifestyle did not affect symptom burden or well-being, although physical activity played a large role in both (P<0.005).

The study was published in the March 15 issue of Cancer.

Cancer and its treatments are associated with a higher level of actionable symptoms and greater loss of wellbeing over time in older breast cancer survivors than in comparable noncancer populations, suggesting the need for surveillance and opportunities for intervention, summarized the study authors.

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Breast Cancer Survivors Suffer Greater Loss of Well-Being than Noncancer Patients Later in Life - DocWire News

Patients undergoing chemotherapy or radiation therapy at the SECU Comprehensive Cancer Center at CarolinaEast Medical Center can receive three complimentary oncology massage treatments.

Arnie Smalldridge, a former administrative assistant at CarolinaEast, said she was inspired to pursue oncology massage therapy training after seeing how massaging her mother-in-laws feet helped to relieve cancer pain.

She also served as secretary to a patient and family advisory where she heard cancer patients talk about what helped to relieve them from pain.

While we were building the foundation of the cancer center, there were two patients who said massage was the only thing that helped them to handle their pain, Smalldridge said. I knew then that I wanted to go back to school. I was just blessed that CarolinaEast opened up this position for me.

Smalldridge graduated from a massage therapy program at Lenoir Community College in 2017, received an online certificate of completion for oncology massage and in May completed 32 hours of hands-on oncology massage therapy training in Raleigh.

It definitely was a calling, she said. Ive always believed strongly in the power behind the human touch. Sometimes I have patients in here and they live alone. They dont really have a caregiver. Just having someone to touch them and soothe them in that manner, thats all they need. Its psycho-social, if you will.

About five patients a day receive 45-minute treatments in her massage room at the cancer center. The low lighting, relaxing music and aroma therapy helps them to relax, she said.

I sit down with them first and talk with them about their condition to better know what I need to do for them, Smalldridge said. When you do oncology massage therapy, you have to be very mindful of your pressure with an oncology patient. If there is a tumor site, you have to avoid that.

She said oncology massage therapy is different from typical massage therapy in that the therapist must know where the cancer is in the patients body, the types of treatment they are undergoing and any side effects theyre experiencing.

You have to know if the cancer has spread, especially if it has metastasized into the bone marrow, Smalldridge said. The bones can be so fragile that you really want to watch your pressure in that area. You want to avoid any tumor sites. But you do want to focus on the tissue in those areas where the pain is and just do a very light treatment on them to try to release those tissues.

She said oncology massage therapy helps patients to relax and manage their pain better without the use of many pain medications.

It helps their sleep, improves immune function, Smalldridge said. They get peripheral neuropathy relief from massage and they get relief from nausea. They have so many side effects from their medications as far as joint pain, inflammation. Massage helps with that as well.

Therapy also helps with patients undergoing radiation treatments, she said.

The radiation treatment targets the tumor site, but it also irradiates tissues around that site, Smalldridge said. Breast cancer patients can end up with frozen shoulders. Humans guard themselves from pain. You see this in breast cancer patients. They throw their shoulders forward, which messes up their entire gait.

Some patients fear the pain they feel means the cancer has spread or metastasized, she said.

What I do is I help them to understand that these are side effects, that its not a metastasized site, Smalldridge said.

She usually sees patients who are in treatment for cancer, but doctors have referred some patients to her who are three to five years out of treatment.

What I have seen there is that even in their survivor state, three to five years later, theyre still showing effects of the chemo treatment or the radiation treatment, Smalldridge said. They have to get used to the new normal.

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CarolinaEast oncology massage therapist followed calling [sponsored content] - New Bern Sun Journal

Bone remodeling and regeneration are dependent on resident stem/progenitor cells with the capability to replenish mature osteoblasts and repair the skeleton.

Until now, it has been thought that stem cells for bone lie within the bone marrow and the outer surface of the bone. Many studies have described the existence of a network of vascular channels that helped distribute blood cells out of the bone marrow. However, none of the studies had proved the existence of cells within these channels.

A new study by the scientists from the UConn School of Dental Medicine has discovered the population of stem cells that reside along the vascular channels within the cortical bone and have the ability to generate new bone. These stem cells stretch across the bone and connect the inner and outer parts of the bone.

Lead investigator Dr. Ivo Kalajzic, professor of reconstructive sciences, said, This is a discovery of perivascular cells residing within the bone itself that can generate new bone-forming cells. These cells likely regulate bone formation or participate in bone mass maintenance and repair.

This is the first study that reports the existence of these progenitor cells within the cortical bone that can generate new bone-forming cellsosteoblaststhat can be used to help remodel a bone.

To reach this conclusion, the scientists observed the stem cells within an ex vivo bone transplantation model. These cells migrated out of the transplant and started to reconstruct the bone marrow cavity and form new bone.

However, further study is required to determine the cells potential to regulate bone formation and resorption.

The study is presented in the journal Stem Cells.

Excerpt from:
These new stem cells have the ability to generate new bone - Tech Explorist

Gosselies, Belgium, 11 March 2020, 7am CET BONE THERAPEUTICS(Euronext Brussels and Paris: BOTHE), the bone cell therapy company addressing high unmet medical needs in orthopaedics and bone diseases, today announces its business update and full year financial results for the year ending 31 December 2019, prepared in accordance with IFRS as adopted by the European Union.

During the past year, Bone Therapeutics has laid a strong foundation for advancing our key assets, the allogeneic cell therapy platform ALLOB and the enriched protein solution JTA-004, into the next phase of clinical development and beyond, saidMiguel Forte, MD, PhD, CEO of Bone Therapeutics.We have obtained additional clinical evidence supporting the safety and efficacy for ALLOB in patients undergoing spinal fusion procedures. We have also successfully implemented the optimised allogeneic cell therapy manufacturing process and additionally submitted the clinical trial applications for the crucial Phase III JTA-004 and Phase IIb ALLOB studies. With the preparation of both clinical trials complete, we are fully focussed on timely execution of our clinical programmes and delivering our business and partnering strategy in 2020. This will enable us to move toward our goal of creating innovation solutions that will make a true difference in the lives of patients suffering from debilitating orthopaedic conditions.

Clinical and operational highlights during 2019

Corporate highlights 2019

Financial highlights 2019

Outlook for the remainder of 2020

Bone Therapeutics anticipates starting patient recruitment for the Phase III study with JTA-004, for the treatment of pain in patients with knee osteoarthritis in Q1 2020, subject to the approval of the CTA by the regulatory authorities.

The company has started the CTA submission process in Europe for a Phase IIb clinical trial with its allogeneic bone cell therapy product, ALLOB, in patients with tibial fractures at risk for delayed healing, using its optimized production process. The company expects to enroll the first patient in Q2 2020.

In the second half of 2020, the company expects to report results from the 2-year follow-up period of thePhaseIIa study with ALLOB in patients undergoing a spinal fusion procedure.

Good cost and cash management will remain a key priority. The net cash burn for the full year 2020 is expected to be in the range of 15-17 million assuming normal operation as the effect of the ongoing COVID-19 epidemy cannot be excluded. The situation will be actively and closely monitored. The company anticipates having sufficient cash to carry out its business objectives into Q3 2020.

In this context, strengthening the cash position is a key priority. The company is currently evaluating and working on different financing options and plans to raise new funds from the capital markets and/or through alternative funding strategies.

Conference call

Miguel Forte, MD, PhD, CEO, and Jean-Luc Vandebroek, CFO, will host a conference call today at 5pm CET / 11am EST / 8am PST. To participate in the conference call, please select your dial-in number from the list below quoting the conference ID 7547944#:

Belgium: +32 (0)800 48 740 / +32 (0)2 400 98 74France: +33 (0)805 103 028 / +33 (0)1 76 70 07 94United Kingdom: +44 (0)800 376 7922 / +44 (0)844 571 8892United States: +1 (866) 966 1396 / +1 (631) 510 7495

Shortly prior to the call, the presentation will be made available on the Investors section of the Companys website. A replay will be available by dialling the following number +44 (0)333 300 9785 / +33 (0)1 70 95 03 48 and by using the conference ID: 7547944#

About Bone Therapeutics

Bone Therapeutics is a leading biotech company focused on the development of innovative products to address high unmet needs in orthopedics and bone diseases. The Company has a broad, diversified portfolio of bone cell therapies and an innovative biological product in later-stage clinical development, which target markets with large unmet medical needs and limited innovation.

Bone Therapeutics is developing an off-the-shelf protein solution, JTA-004, which is entering Phase III development for the treatment of pain in knee osteoarthritis. Positive Phase IIb efficacy results in patients with knee osteoarthritis showed a statistically significant improvement in pain relief compared to a leading viscosupplement. The clinical trial application (CTA) to start the pivotal Phase III program has been submitted to the regulatory authorities in Europe and Hong Kong SAR. The trial is expected to start in Q1 2020.

Bone Therapeutics other core technology is based on its cutting-edge allogeneic cell therapy platform (ALLOB) which can be stored at the point of use in the hospital, and uses a unique, proprietary approach to bone regeneration, which turns undifferentiated stem cells from healthy donors into bone-forming cells. These cells can be administered via a minimally invasive procedure, avoiding the need for invasive surgery, and are produced via a proprietary, scalable cutting-edge manufacturing process. Following the promising Phase IIa efficacy and safety results for ALLOB, the Company has started the CTA submission procedure with the regulatory authorities in Europe to start the Phase IIb clinical trial with ALLOB in patients with difficult-to-heal fractures, using its optimized production process.

The ALLOB platform technology has multiple applications and will continue to be evaluated in other indications including spinal fusion, osteotomy and maxillofacial and dental applications.

Bone Therapeutics cell therapy products are manufactured to the highest GMP (Good Manufacturing Practices) standards and are protected by a broad IP (Intellectual Property) portfolio covering ten patent families as well as knowhow. The Company is based in the BioPark in Gosselies, Belgium. Further information is available at http://www.bonetherapeutics.com.

Contacts

Bone Therapeutics SAMiguel Forte, MD, PhD, Chief Executive OfficerJean-Luc Vandebroek, Chief Financial OfficerTel: +32 (0) 71 12 10 00investorrelations@bonetherapeutics.com

International Media Enquiries:Image Box CommunicationsNeil Hunter / Michelle BoxallTel: 44 (0)20 8943 4685neil@ibcomms.agency / michelle@ibcomms.agency

For French Media and Investor Enquiries:NewCap Investor Relations & Financial CommunicationsPierre Laurent, Louis-Victor Delouvrier and Arthur RouillTel: + 33 (0)1 44 71 94 94bone@newcap.eu

Certain statements, beliefs and opinions in this press release are forward-looking, which reflect the Company or, as appropriate, the Company directors` current expectations and projections about future events. By their nature, forward-looking statements involve a number of risks, uncertainties and assumptions that could cause actual results or events to differ materially from those expressed or implied by the forward-looking statements. These risks, uncertainties and assumptions could adversely affect the outcome and financial effects of the plans and events described herein. A multitude of factors including, but not limited to, changes in demand, competition and technology, can cause actual events, performance or results to differ significantly from any anticipated development. Forward looking statements contained in this press release regarding past trends or activities should not be taken as a representation that such trends or activities will continue in the future. As a result, the Company expressly disclaims any obligation or undertaking to release any update or revisions to any forward-looking statements in this press release as a result of any change in expectations or any change in events, conditions, assumptions or circumstances on which these forward-looking statements are based. Neither the Company nor its advisers or representatives nor any of its subsidiary undertakings or any such person`s officers or employees guarantees that the assumptions underlying such forward-looking statements are free from errors nor does either accept any responsibility for the future accuracy of the forward-looking statements contained in this press release or the actual occurrence of the forecasted developments. You should not place undue reliance on forward-looking statements, which speak only as of the date of this press release.

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Bone Therapeutics announces 2019 full year results - OrthoSpineNews

The primary participants engaged in precision medicine market include Novartis, Qiagen, Biocrates Life Sciences, Pfizer, Eagle Genomics, Tepnel Pharma Services

PUNE, India, March 11, 2020 /PRNewswire/ -- Precision medicine is a healthcare model that enables the dynamic methodology of healthcare, with medical choices, diagnosis, policies, or items being custom-made to the specific patient. Methodologies involved in precision medicine majorly include molecular diagnostics, imaging, and analytics. The global precision medicine market is growing at a spectacular rate owing to growing online interactive forums, growing attempts to classify genes and advances in cancer biology which have become the key factors driving the growth of this sector. The basic concept of precision medicine is to understand the genetic makeup and variation at a population level, and further at an individual level, in order to tailor a medication that targets a specific gene type. Sequencing or characterizing genes is therefore the most important method of gathering information on genes and their possible mutations. Precision medicine includes the administration of panomic examination to examine the after effects of individual patient's disease and then to utilize targeted treatments to identify the individual patient's disease timeframe and to provide better diagnostic solutions.

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Technological advances in big data analysis and the introduction of new technologies will have a positive impact on the growth of the precision medicine market. It is anticipated that the attention of healthcare and diagnostic companies on providing several new oncology and respiratory technologies among others will help the overall growth of the industry. In addition, precision medicine software is specifically designed to develop precise medicines which are used in the treatment of chronic and genetic diseases to ensure faster recovery of patients. Massive demand for such software will increase the growth of the precision medicine market in healthcare companies for better patient engagement. Furthermore, rising applications in artificial intelligence is further advancing the precision medicine initiative. Machine learning algorithms are applied for changing genomic sequence and to analyze and draw conclusions from the massive volumes of patients' information.

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Global Precision Medicine Market was Estimated to Grow at a Rate of 20.9% During the Forecast Period due to Increasing Focus of Healthcare Sector on...

PROOF 302 Trial Enrolling Subjects with Invasive Urothelial Carcinoma with Susceptible FGFR3 Genetic Alterations

Ohio State University-Led Trial to Study Infigratinib for Treatment of Patients with Advanced or Metastatic Solid Tumors with FGFR Genetic Alterations

SAN FRANCISCO, March 12, 2020 (GLOBE NEWSWIRE) --BridgeBio LLC, Inc. (Nasdaq: BBIO) affiliate company QED Therapeutics announced today that patients have been dosed in separate Phase 3 and Phase 2 clinical trials of infigratinib in cancer indications.

The Phase 3 PROOF 302 trial sponsored by QED is studying infigratinib for the adjuvant (post-surgery) treatment of invasive urothelial carcinoma. A second, investigator-initiated trial, led by Sameek Roychowdhury, M.D., Ph.D., of The Ohio State University (OSU) Comprehensive Cancer Center, is studying infigratinib for the treatment of advanced and metastatic solid tumors with confirmed FGFR gene fusions/translocations or other FGFR alterations.

In the PROOF 302 trial, investigators are enrolling subjects with invasive urothelial cancer harboring susceptible FGFR3 genetic alterations who are at high risk of recurrence following surgical resection. Subjects will be randomized (1:1) to receive once daily oral infigratinib or placebo. The primary outcome is disease-free survival, and secondary outcomes include metastasis-free survival, overall survival, and safety and tolerability measures.

Many patients with invasive urothelial carcinoma will have their cancer recur within two years after surgery, said PROOF 302 trial lead Sumanta Pal, M.D., professor of medical oncology and therapeutics research at City of Hope Comprehensive Cancer Center. Correspondingly, I believe there are many patients who could benefit from an oral, post-surgery treatment option that targets FGFR3 alterations, the genetic driver of many urothelial carcinomas.

The Phase 2 study at OSU and selected sites within the Oncology Research Information Exchange Network (ORIEN)will evaluate the efficacy of infigratinib in patients who have advanced or metastatic solid tumors that are positive for FGFR1-3 gene fusions/translocations or other FGFR alterations. The open-label study will assess overall response rate as the primary outcome. Secondary outcomes include progression-free survival, best overall response, disease control rate, overall survival and measures of safety and tolerability.

Increasingly, oncologists are learning to classify their patients cancers based on genetic mutations, going beyond the origin of the tumor, noted Dr. Roychowdhury. Given the activity we have seen with infigratinib in FGFR2-fusion-driven bile duct cancers and FGFR3-altered urothelial carcinoma, our hope is that infigratinib will demonstrate similar activity in additional cancers that appear to be driven by alterations in FGFR. There appear to be multiple FGFR alterations that can drive cancer growthand we hope to see these patients benefit too.

For additional information on the PROOF 302 trial, including eligibility, patients should ask their physician, visit clinicaltrials.gov, or email PROOF302@QEDtx.com.

For additional information on the Phase 2 trial in metastatic solid tumors with FGFR gene alterations, including eligibility, patients should ask their physician, visit clinicaltrials.gov, or email OSUCCCClinicaltrials@osumc.edu.

About QED Therapeutics QED Therapeutics, an affiliate of BridgeBio Pharma, is a biotechnology company focused on precision medicine for FGFR-driven diseases. Our lead investigational candidate is infigratinib (BGJ398), an orally administered, FGFR1-3 selective tyrosine kinase inhibitor that has shown activity that we believe to be meaningful in clinical measures, such as overall response rate, in patients with chemotherapy-refractory cholangiocarcinoma with FGFR2 fusions and advanced urothelial carcinoma with FGFR3 genomic alterations. QED intends to submit a New Drug Application (NDA) with the United States Food and Drug Administration (FDA) for second and later-line cholangiocarcinoma in 2020. QED Therapeutics is also evaluating infigratinib in preclinical studies for the treatment of achondroplasia. We plan to conduct further clinical trials to evaluate the potential for infigratinib to treat patients with other FGFR-driven tumor types and rare disorders.

For more information on QED Therapeutics, please visit the companys website at qedtx.com.

About BridgeBio Pharma, Inc.

BridgeBio is a team of experienced drug discoverers, developers and innovators working to create life-altering medicines that target well-characterized genetic diseases at their source. BridgeBio was founded in 2015 to identify and advance transformative medicines to treat patients who suffer from Mendelian diseases, which are diseases that arise from defects in a single gene, and cancers with clear genetic drivers. BridgeBios pipeline of over 20 development programs includes product candidates ranging from early discovery to late-stage development. For more information, visit bridgebio.com.

BridgeBio Pharma Forward-Looking Statements

This press release contains forward-looking statements. Statements we make in this press release may include statements that are not historical facts and are considered forward-looking within the meaning of Section 27A of the Securities Act of 1933, as amended (the Securities Act), and Section 21E of the Securities Exchange Act of 1934, as amended (the Exchange Act), which are usually identified by the use of words such as anticipates, believes, estimates, expects, intends, may, plans, projects, seeks, should, will, and variations of such words or similar expressions. We intend these forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 27A of the Securities Act and Section 21E of the Exchange Act and are making this statement for purposes of complying with those safe harbor provisions. These forward-looking statements, including statements relating to expectations, plans, and prospects regarding QED Therapeutics regulatory approval process, clinical trial designs, clinical development plans, clinical trial results, timing and completion of clinical trials, clinical and therapeutic potential of infigratinib, reflect our current views about our plans, intentions, expectations, strategies and prospects, which are based on the information currently available to us and on assumptions we have made. Although we believe that our plans, intentions, expectations, strategies and prospects as reflected in or suggested by those forward-looking statements are reasonable, we can give no assurance that the plans, intentions, expectations or strategies will be attained or achieved. Furthermore, actual results may differ materially from those described in the forward-looking statements and will be affected by a number of risks, uncertainties and assumptions, including, but not limited to, QED Therapeutics ability to initiate and continue its ongoing and planned clinical trials of infigratinib, the availability of data from these trials, its ability to advance infigratinib in clinical development according to its plans, and the timing of these events, as well as those risks set forth in the Risk Factors section of BridgeBio Pharma, Inc.s most recent Annual Report on Form 10-K and our other SEC filings. Moreover, QED Therapeutics operates in a very competitive and rapidly changing environment in which new risks emerge from time to time. Except as required by applicable law, we assume no obligation to update publicly any forward-looking statements, whether as a result of new information, future events or otherwise.

QED Contact:Carolyn HawleyCanale Communicationscarolyn@canalecomm.com858-354-3581

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BridgeBio Pharma's QED Therapeutics Announces Dosing of First Patients in Phase 3 and Phase 2 Clinical Trials of Infigratinib in Tumors with FGFR...

As the coronavirus reaches more than 100 countries and the WHO declares nCoV as a global pandemic, Pharmaceutical Technology lists the top ten most affected countries by the Covid-19 coronavirus outbreak in China, by the number of cases.

China, including Hong Kong and Macau, is the worst affected country by the novel coronavirus (nCoV) outbreak, officially named Covid-19 by the World Health Organization (WHO).

China witnessed more than 3,000 deaths and approximately 74% of the global coronavirus cases as of 09 March, which quickly came down to approximately 67% by 11 March as the number of cases in rest of the world surged.

Hubei is the most-affected province within China and Wuhan, the capital city of Hubei, is the city affected worst by the coronavirus. Hubei has witnessed more than 67,000 coronavirus-positive cases as of 11 March.

The number of cases in China, however, has been on the decline starting March due to the rapid control measures and response by the Chinese government.

Coronavirus is getting severe in Italy, making it the most-affected in Europe as well as outside Asia. Travel to Italy and Italians travelling to other countries during the outbreak has been traced to have caused Covid-19 spread.

Northern Italy, where the majority of the Italian Covid-19 cases are recorded, is kept on a high alert with affected cities locked-down. The Italian governments early measures such as closing educational institutions temporarily might have limited the spread, although the aged population remains a concern.

Coronavirus deaths in Italy raised sharply from 366 on 08 March to 631 on 10 March and further to 827 on 11 March. Total cases reached 12,462.

Iran, another country from where coronavirus spread to rest of the world, currently has more than 9,000 confirmed cases and has recorded 354 deaths. Iran has been suspected to have delayed acknowledging the spread of corona virus in their country and under-reporting the cases.

A number of countries have traced their coronavirus-infected having contracted the disease during travel to Iran. Many government officials and politicians including MPs in Iran have contracted coronavirus, some of who died.

Amid fears of further coronavirus spread, Iran announced the temporary release of approximately 70,000 prisoners, according to Mizan news agency.

South Korea is hit the most by coronavirus infection outside China due to its proximity to the latter. Coronavirus cases in South Korea started surging in February and are currently close to reaching 7,900.

Deaths due to coronavirus in South Korea reached 66. The country is being assisted by China, whose experience in containing the outbreak has resulted in controlling the local spread of the epidemic.

France is the second most-affected European nation by the 2019 coronavirus. Covid-19 nCoV cases in France have reached 2,284, while death toll got close to 50.

The French government has banned public gatherings involving more than 1,000 people. The popular Louvre Museum in Paris was temporarily closed as a precautionary measure. The Paris city has reported Covid-19 coronavirus-positive cases, apart from other regions including Amiens, Bordeaux, and Eastern Haute-Savoie.

A worker at Disneyland Paris was reported by Reuters as having contracted the coronavirus. France currently has only a few clusters with coronavirus. The ongoing outbreak remains a concern to the French tourism industry as coronavirus fears are resulting in a drop in visitors.

Since the first coronavirus case confirmed on 01 February, the Spanish Covid-19 nCoV-infected cases got closer to 1,000 in early hours of 09 March and rose sharply to 2,277 by 11 March.

Spain is the second most-affected European country with coronavirus. Spanish coronavirus death toll has increased to 55 making the government and citizens nervous.

Tourism, a crucial sector for Spain, is expected to face an adverse impact due to the global coronavirus fears. The Spanish government has advised companies to ask employees to work from home to avoid spread.

Germany, which borders France and Switzerland, also has hundreds of coronavirus-positive cases, which stand at 1,966 currently.

Similar to its neighbour France, Germany too banned public events involving huge crowds in order to prevent spread. Trade fair, The Hannover Messe, has been postponed due to the coronavirus outbreak situation.

Germany has reported three coronavirus deaths as of 11 March.

Coronavirus situation in the US is grim with the cases and deaths increasing fast. The US Covid-19 cases nearly doubled in two days, to cross 1,300 on 11 March, while the death toll passed 30.

Community spread and delayed testing is currently a major concern to Americans as enough test kits are not available across states.

The first coronavirus case in the US was confirmed on 21 January, but the cases surged from the second half of February.

Japan was among the countries that reported first coronavirus cases early following the Wuhan outbreak. In addition to the cases reported on cruise ship Diamond Princess docked in Japanese waters, the country reported 639 Covid-19 cases as of 11 March.

The Japanese governments response to containing the spread among those onboard the Diamond Princess cruise ship met with criticism.

Japan has witnessed 17 deaths due to coronavirus and is likely to feel an impact on travel and trade.

Switzerland, a popular tourist destination, is the fifth most affected European country by the novel coronavirus outbreak. The positive Covid-19 coronavirus cases in Switzerland, whose borders are close to Milan, Italy, crossed 650 on 11 March.

Some of the major cities in Switzerland, such as Geneva and Zurich, have reported confirmed coronavirus cases.

Three deaths have been reported in Switzerland due to coronavirus. The Swiss hotel and tourism industries will be affected if the coronavirus situation continues to stay for long.

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Vertex's Trikafta: treating the genetic basis of cystic fibrosis - Pharmaceutical Technology