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Stem Cells from Fat vs. Bone Marrow – Best Sources for …

March 3rd, 2020 1:41 pm

Stromal vascular fraction was dramatically better than bone marrow concentrate in its ability to differentiate into cartilage.Two other important features were also well documented in this study. SVF created significantly more colony forming units than BMC, another significant predictor of healing response. Perhaps most importantly, SVF was dramatically better than BMC in its ability to differentiate into cartilage.

Second, a study by Han Chao et al has also demonstrated that fat derived stem cells also have a higher proliferation potential for neural tissue and are a better source for not only cartilage regeneration but also for nervous system regeneration.

The studies gave a very comprehensive look at comparing BMC and SVF in the ability to repair cartilage damage in a same procedure protocol. Every significant measurement comparing bone marrow to adipose tissue for stem cell harvesting demonstrated that adipose derived stem cells provided better cell content and superior ability to differentiate into cartilage than bone marrow. Our extensive clinical experience with the procedure for Colorado patients suffering from pain in the knees, other joints, soft tissue, and a wide range of back problems clearly demonstrates the same.

Using the most effective combination of autologous stem cell sources is one of several criteria to identify a legitimate stem cell clinic. Other important characteristics we recommend paying attention to when choosing a stem cell clinic, include the presence of a physician who owns and operates the clinic, X-ray guided injections administered by a trained injection specialist, and a clinic that takes time to discuss your questions. A review of your imaging and clinical data is needed in order to determine if stem cell therapy is right for you.

*Individual patient results may vary. Contact us today to find out if stem cell therapy may be able to help you.

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MAX BioPharma Announces Key Update to its Liver Fibrosis Program Showing Efficacy of an Oxysterol Lead Drug Candidate in Inhibiting NASH in a…

March 3rd, 2020 1:41 pm

MAX BioPharma is Pursuing Strategic Partnerships and Series A Financing

LOS ANGELES, March 3, 2020 /PRNewswire/ --MAX BioPharma, Inc. (www.maxbiopharma.com) recently published an article describing its anti-tumorigenic oxysterol lead compound, Oxy210, in the peer-reviewed journal, Cells. (https://www.mdpi.com/2073-4409/8/10/1297/pdf). Oxy210 is derived from the Company's Oxysterol Therapeutics platform of proprietary oxysterols. Oxy210 was shown to inhibit two key cellular pathways, Hedgehog and transforming growth factor beta (TGFb), which play important roles not only in cancer but also in driving pathologic fibrosis in a number of organs including liver, lung and kidney. Oxy210 has unique mechanisms of action compared to other Hedgehog and TGFb signaling inhibitors that are commercially available or under clinical development. This new drug candidate is orally bioavailable, has favorable pharmacokinetic and safety profiles, is scalable, and was found to inhibit activation and pro-fibrotic activities of human liver stellate cells that drive fibrosis.

In a recent 16-week study conducted at UCLA under the direction of Drs. Jake Lusis and Simon Hui, Oxy210 was found to significantly inhibit development of fibrosis in a humanized mouse model of non-alcoholic steatohepatitis (NASH) that involves progressive inflammation, fat deposition and fibrosis in the livers of these mice. The inhibition of fibrosis involved inhibited expression of TGFb, NLRP3 inflammasome, and inflammatory cytokines: interleukin-6 (IL-6), tumor necrosis alpha (TNF-a), and monocyte chemotactic protein 1 (MCP-1) in the liver and plasma of mice that consumed Oxy210 incorporated in their food. Moreover, Oxy210 inhibited lipid deposition, including total cholesterol, unesterified cholesterol, cholesterol ester, and phospholipids in the livers of the hyperlipidemic mice.

"There is an urgent need for therapies to treat fatty liver disease, and I find the results of our studies with MAX BioPharma quite exciting," states Dr. Lusis, Principal Investigator and Professor of Medicine, Human Genetics, Microbiology, Immunology & Molecular Geneticsat UCLA.

"Our humanized hyperlipidemia mouse model of NASH reflects the natural history of non-alcoholic fatty liver disease (NAFLD) progression in humans and reproduces the salient features of human NASH. Attenuation of hepatic fibrosis and inflammation by Oxy210 suggest that it could be a promising therapeutic for human NASH," explains Dr. Hui, Project Scientist and Co-Principal Investigator at UCLA.

"Evidence that the Hedgehog-TGFb inhibitor, Oxy210, improves liver inflammation and fibrosis in the mouse model of NASH is encouraging given growing evidence that these signaling pathways critically control liver repair and are dysregulated in patients with NASH, cirrhosis and primary liver cancer," states Dr. Anna Mae Diehl, Florence McAlister Distinguished Professor of Medicine at Duke University.

MAX Biopharma is currently optimizing oral dosing with Oxy210 and performing pre-clinical studies required by the FDA for clinical development and commercialization, and is seeking strategic partnerships with biotechnology and pharmaceutical companies that have the expertise and resources to further the development of oxysterols towards FDA approval and commercialization. In addition, MAX BioPharma is in the process of raising a series A financing round to support the advancement of its therapeutic development programs. "We are very excited and hopeful that our efforts will result in an effective and safe therapy for NASH that will significantly improve the lives of those affected by this currently incurable disease" says Dr. Farhad Parhami, Founder, President and CEO of MAX BioPharma.

About MAX BioPharma, Inc.

MAX BioPharma is a privately-held preclinical stage California-based biopharmaceutical company developing novel small molecule lipids as drug candidates for intervention in debilitating and fatal human diseases. The company will be a leader in a new field of Oxysterol Therapeutics by leveraging a robust and growing intellectual property portfolio that will lead to treatments for numerous indications. MAX BioPharma's first success based on small molecule lipids has contributed to the discovery of novel osteogenic oxysterol compounds that target multipotent mesenchymal cells, including mesenchymal stem cells, to induce the formation of bone-forming osteoblasts and bone. The company is translating this technology into the next generation of therapeutic agents for stimulation of bone formation, locally and systemically, in indications such as spinal fusion, non-union fractures, and osteoporosis. MAX BioPharma is also pursuing the development of small molecule oxysterols that function as anti-tumorigenic Hedgehog and TGFb pathway antagonists that will be more effective than currently known antagonists in treating a variety of cancers, including lung and pancreatic cancer, and hematologic malignancies, as well as fibrotic diseases of liver, lung, and kidney among others. For more information please visit us at http://www.maxbiopharma.com

Media Contact: Farhad Parhamifparhami@maxbiopharma.com

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Uveitis Treatment Market Research Report: Analysis by SWOT, Capacity, Production and Value Future Forecast To 2025 – News Times

March 2nd, 2020 2:50 am

Global Uveitis Treatment Market: Global Size, Trends, Competitive, and Historical & Forecast Analysis, 2019-2025Increasing demand for advanced healthcare products and rising number of patients affected by Cataract and other eye related diseases are some factors driving the growth of Global Uveitis Treatment Market.

Global Uveitis Treatment Market is valued around USD 475.7 Million in 2018 and expected to reach USD 724.8 Million by 2025 with the CAGR of 6.2% over the forecast period.

Uveitis disease directly affects the eyes and the most common symptoms of uveitis are eye inflammation and swelling that can destroy eye tissues. Whether its humans eye or any animals, uveitis affects everyone and can lead to poor vision or blindness. It is named as uveitis because mostly the swelling affects the part of eye which called uvea. Basically eye is made of several layers and uvea is the middle layer, its between white part of eye and the inner layers of eye which called the sclera.

Uvea has three important structures the iris, the ciliary body and the choroid. The Iris is colored circle at the front of eye, the ciliary body helps to focus eye lens and makes fluid that nourishes inside of eye and the choroid is group of blood vessels which gives the nutritions to the retina it needs. People who are suffering from AIDS, Ankylosing spondylitis, Behcets disease, CMV retinitis, Herpes zoster infection, Histoplasmosis, Kawasaki disease, Multiple sclerosis, Psoriasis, Reactive arthritis, Rheumatoid arthritis etc. have greater risk of having uveitis than normal people.

Global uveitis treatment market is segmented on the basis of type, application and region & country level. On the basis of type, the market is segmented into anterior uveitis, posterior uveitis, intermediate uveitis and Panuveitis. On the basis of application, the market is segmented into hospital pharmacies, retail pharmacies, online pharmacies and drug stores.

The regions covered in this Uveitis Treatment Market report are North America, Europe, Asia-Pacific and Rest of the World. On the basis of country level, market of Uveitis Treatment is sub divided into U.S., Mexico, Canada, U.K., France, Germany, Italy, China, Japan, India, South East Asia, GCC, Africa, etc.

Global Uveitis Treatment Market report covers prominent players like Allergan, Bausch & Lomb, Novartis, AbbVie, Santen Pharmaceutical, Eyegate Pharmaceuticals, Alimera Sciences.

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Market Dynamics-

Advanced technological requirements in healthcare, increasing disposable income and high expenditure on healthcare are some of the factors driving the market of uveitis treatment. Uveitis can affect eyes through dirt, pollution, viral, fungal, bacterial infections, etc. and uveitis cause cataract. Cataract is responsible for worlds around 51% of blindness which is about 20 million people. Smokers have more risk of uveitis and of blindness. There are around 1.2 million people who are smokers, there is a huge number of smokers some of them are suffering from diseases and 80% of them are from low and middle income countries. Thus, all these factors are expected to foster the growth of this market.

However, high cost of treatment and lack of skilled professionals can restrain the market growth. In spite of this, technological advancement, increasing numbers of hospitals, diagnostic centers, online treatments are some factors which can provide various opportunities for the further growth of the market.

North America is expected to dominate the Global Uveitis Treatment owing to the high investment in this field. In addition, research and development by leading players to develop new innovative products in this region is also fostering the market growth. For example, Allergan expanded REFRESH portfolio with new REFRESH, RELIEVA Lubricant Eye Drop Product Line. The annual direct medical cost in the US is estimated to USD 117 million. Uveitis accounts 10% of blindness globally. 60%-80% uveitis patient occur in patient in third to sixth decade of life with an age of occurrence of 35. The prevalence of uveitis is estimated 17 per 100000 in Europe which is comparable to the US. Uveitis is one of the major reasons for the birth of cataract and it accounts for 30%50% of blindness in most Asian countries.

By Product Type:

By Application:

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RNIB Scotland report highlights problems faced by patients with severe sight and blindness – AOP

March 2nd, 2020 2:50 am

The charity calls for Scottish health boards to ensure that accessible information policies are implemented

Blind and partially sighted people are still struggling to receive healthcare information in a format that is accessible to them, according to new research published by the Royal National Institute of Blind People (RNIB) Scotland.

The Communications failure report released by the charity last week (17 February) highlights that patient confidentiality is breached when people have to rely on carers, relatives and friends to read appointment letters, medication and test results.

Author of the report, Laura Jones warned: This can put patients at risk of missing treatment as well as being confused or misinformed about their healthcare needs. The NHS, itself, puts great emphasis on the cost, in money and time, of missed appointments to over-burdened clinics, so giving patients accessible information makes sense.

The report was launched by MSP Stuart McMillan and calls for the countrys 14 health boards to ensure that accessible information policies are implemented. It also encourages awareness training for all healthcare staff.

Ms Jones highlighted that it has been almost 10 years since The Patients Rights (Scotland) Act 2011 was introduced. The charter states You have the right to be given information about your care and treatment in a format or language that meets your needs.

The report found that some patients had not been informed that they could request information in alternative formats, while others lacked the confidence to request information in accessible formats as they did not want to be considered a burden or difficult.

While the report notes that increasingly healthcare information is provided online, people with disabilities show low levels of digital uptake.

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Blind pug and his seeing-eye chihuahua in need of forever home – FOX 29 News Philadelphia

March 2nd, 2020 2:50 am

GREELEY, Colo. - Augie, a 12-year-old pug has never seen his best friend Pepe, achihuahua, but that doesnt matter. The two have been inseparable for years.

The duo arrived at the Colorado Pug Rescue after their owner was diagnosed with a terminal illness.

Augie has been blind most of his life, according to foster parent Cyndi Trimber. They sleep together, she said. Its really sweet. Its really sweet that they kind of depend on each other like that.

Unfortunately, the pugs emotional support pal couldnt prepare him for what would happen next. Augies blindness was so bad, he had to have both of his eyes removed a couple of weeks ago. Plus, some major dental surgery.

The group was billed $3100 for the operations, emergency money they didnt expect to spend, given it helps more than 100 pugs throughout the year.

Trimber said, I went to pick him up and Im like, Holy! Its a foster group. You know? Where are we going to get that kind of money?

The Colorado Pug Rescue is hoping some kind folks will help with donations and perhaps provide these best friends with a forever home.

I just want them to have the best possible life they can have, Trimber explained.

Learn more about how to help Augie and Pepe here.

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Harikrishnan KS’ graduating collection makes a noise at the London College of Fashion – Ahmedabad Mirror

March 2nd, 2020 2:50 am

HE has become a global sensation among the fashion press, even though he hasnt debuted professionally yet. Harikrishnan KS, 26, just presented his graduating collection at the UKs cutting-edge London College of Fashion and received both favourable reviews as well as trolling for his unusual silhouettes (musician MC Hammer tweeted hes a fan). The infl atable latex trousers with impossible proportions have been featured on the BBC and in magazines like the British Vogue, i-D and Dazed, to name a few. Hari, as he calls himself, hails from Kerala and studied at NIFT Bangalore, before he went on to assist the talented Woolmark Prize winner Suket Dhir in New Delhi. People are going nuts about him, his collection was really avant-garde, Dhir says proudly. Hari, who suff ers from colour blindness, tells your diarist, I was playing with my dog when I decided to see myself through his eyes. Its almost like seeing the world through a fi sh-eye lens. He adds he has no interest in selling his infl atable pants, but has received a couple of orders for music video costumes. Haris fashion heroes are French graphic designer and illustrator Jean-Paul Goude, and Dhir, of course.

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Harder to Rx but Easy on the Eyes, These 9 Styles Make the Lenses the Main Attraction – InvisionMag

March 2nd, 2020 2:50 am

Part of the newly introduced Titan Accent Shades Collection, the 8174_7530 brings the hinge-free, three-piece mount frames of Titan Minimal Art together with the shapes of the brands Accent Shades.

(518) 272-5500, silhouette.com

$420

Offering a generous nod to the Palme dOr, the highest award given at the Cannes Film Festival, the SCHD48S features a palm-leaf pattern on each lens and is part of the Palm Collection, naturally.

(800) 423-3023, derigo.us

$750

Blings the thing for this MK1058B, putting Swarovski crystals to work on triple-gradient lenses in front of jewelry-chain inspired temples.

(800) 422-2020, my.luxottica.com

$209

Inspired by the Fendi Couture Fall/Winter 2019-20 Collection, the FF 0404/G/S celebrates its iconic logo on an oversized sun with metal-studded temples.

(800) 631-1188, mysafilo.com

$365

A star is born with the GG0666S, a cat-eye shape that makes an impact with Guccis cant miss logo and star-shaped rivets.

kering.com

$725

Direct sunlight brings the Lovelace in gunpowder/18k gold with yellow gradient Stardust lenses to life with speckled lenses by Dalloz Creations.

leisure-society.com

$625

Featuring a mask design and metal micro studs, the MCM694S is defined by double-lens layering and a visible-through-the-temples wire core.

(800) 645-1300, marchon.com

$435

Featured in the Berluti Spring-Summer 2020 Collection, the BL40007U in black acetate features smoke lenses with silver-mirror Scritto print.

thelios.com

$510

The GLCO x Malbon Golf collaboration includes the Hampton, which reveals a Malbon breath logo when and only when the lenses fog up.

garrettleight.com

$340

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"You would have lost vision in both eyes." Jaime Cerreta’s eye health scare – AZFamily

March 2nd, 2020 2:48 am

PHOENIX (3TV/CBS 5) -- "You would have lost vision in both eyes, complete vision loss," that's what Ophthalmologist Dr. Ramin Schadlu told me around 8 p.m. on a Wednesday night.

I looked at my father--who had come with my mother to my emergency appointment at Arizona Retina and Vitreous Consultants. I was beyond scared. The doctor called me "stoic". The truth is, I didn't really believe what he was saying and was slowly swallowing fear.

[WATCH: Jaime Cerreta talks about a health scare that could have blinded her]

There were no major symptoms. Sure, I had been seeing floaters for a few weeks. And the floaters were new. But doesn't everyone see floaters?

I would learn how very important it is to go to the doctor as soon as you see any change in your vision.

I visited my doctor, Dr. Justin Macklin, at LensCrafters at 3 in the afternoon that day. It was during my Local Love that morning, that I noticed a black spot in my vision and I called and asked to come in. After a careful examination, Dr. Macklin leaned back from his equipment and said, "I have some bad news".

That's when I would go immediately for laser treatment. "What I found in your eye was a retinal tear with some fluid around it. When I looked at the other eye, it turned out that you had a confined retinal detachment in the other eye as well," said Schadlu.

Dr. Schadlu told me to go back to the waiting room and he would call me back in for laser treatment. I was in some sort of emergency eye facility at Arizona Retina and Vitreous Consultants. It was way past 6 p.m., yet there was a full waiting room and no one seemed in a hurry to get home. When I asked, the staff told me-- we stay until the last patient's been treated. This retinal injury-- so dire and so important that the staff works on call as well.

That night we would treat the left eye--with the tear--at 8:30 p.m. that night. I would go back the next day to treat my right eye.

So... how did this happen? You can blame my bad eyesight.

"You get it earlier because your eye is longer. A -10 is a longer eye and as a longer eye--it doesn't take much shrinking of the gel to cause tears," said Schadlu.

It's common as we age as the retina thins and could also be genetic.

But Dr. Shadlu says it's also just bad luck. So we rely on that laser to save my vision. The laser treatment takes maybe 20 minutes. It doesn't hurt but is uncomfortable.

I found myself whimpering through the procedure. It's a bright light that I could feel in my optic nerve. That bright light is "spot welding" my retina back in place. So I am grateful for the weird, intense feeling that is ultimately saving my vision. I would spend the next several days away from my phone, away from work and in a strange mental space ping ponging between gratitude and "what if's."

But I learned one thing that I will forever preach.. if you see floaters, flashes of light, or darkness--- get to the doctor within 24 hours. I still have that dark spot in my vision. I have some floaters that look like pepper falling. And sometimes the treated spot "sparkles" when I move from outside to inside.

I am so mad at myself for not going to the doctor sooner. Had I just done that, maybe that black spot wouldn't be there. It is distracting and Dr. Schadlu says my mind will learn to ignore it. But it's a reminder to me of what could have been and that I ignored my health.

I should have gone sooner. Please learn from my mistake. I promise I will take my health more seriously in the future.

Thank you to my friends, family and colleagues who showed me so much love during this journey. Thank you to Dr. Macklin, Dr. Schadlu, Dr. Anita Prasad, and their incredible staff.

Thank you TO YOU for your love and prayers. I am so grateful for the people who watch me on TV and allow me into their lives.

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What to do if the eyes no longer have it – Stuff.co.nz

March 2nd, 2020 2:48 am

Hands up if you've done any of the following recently: moved the candle on a restaurant table closer so you can read the menu; enlarged the text on your phone to read your messages; or given up reading at night because your eyes are just too tired by the end of the day.

You're not alone. After a lifetime without any vision issues it can be a little daunting to discover your eyesight is not as sharp as it used to be. But Specsavers optometrist Ayah Hadi says if you've had more than 40 birthdays, it's reassuring to know you're right on schedule when it comes to needing a little more help to focus and read the fine print.

"It's nothing to worry about, it's just one of those natural processes that happen as we age," she says. "Every day at work I speak with people who describe a whole spectrum of symptoms from taking photos of contracts then magnifying them on their phone so they can read them, to holding their phone further and further away from their face until they have run out of enough arm-length to focus.

"It's a process, and sometimes it takes people a while to accept that things are changing, but it's a good idea to have a chat with an optometrist to figure out what can be done. At the end of the day it's about making sure you can see and continue to do everything you like and need to do in life."

SPECSAVERS/SUPPLIED

Specsavers optometrist Ayah Hadi says if you're over 40 then you might need some help with your eyesight.

These age-related changes to our eyes are known as presbyopia. Our eyes have a flexible, crystalline lens that sits behind the coloured iris, which allows us to see clearly up close and far away. But as we get older, this lens naturally starts to lose its elasticity which affects our ability to focus. Objects close to our eyes become blurry and the point of closest focus moves further away from our eyes.

Hadi says during an eye test, your Specsavers optometrist will figure out what kind of prescription lenses will work best for your eyes and your lifestyle. That could be a pair of reading glasses that makes close work easier, or progressive lenses which combine close, midrange and distance vision into one pair of glasses.

"Alternatively, if you're active or do a lot of sport, you might opt for progressive contact lenses," she says. They're also a possibility if you don't like the idea of wearing glasses, or just want another option.

SPECSAVERS/SUPPLIED

Specsavers optometrist Ayah Hadi, says their complete eye health check includes OCT - an advanced 3D scan of the interior of the eye.

An appointment with a Specsavers optometrist isn't just about finding the right prescription. It's also a complete eye health check that includes OCT - an advanced 3D scan of the interior of the eye which can pick up conditions which aren't natural age-related changes. Early detection of these conditions is key to preventing permanent vision loss.

"It's important to have an eye test at least every two years", says Hadi. "That way we can make sure your eyes are perfectly healthy and the changes you are noticing are just age-related."

With Specsavers stores open seven days a week and offering a variety of discounts, Hadi says quality eye care is very accessible, and she loves seeing the difference a visit can make for people.

"For me it's about that 'wow' moment when someone puts on a prescription lens and says, 'Ahh, I can see!'. It's like pulling out a magic trick."

Book your Specsavers eye test today.

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Oregon Lions Foundation helps kids get the vision treatment they need – Coos Bay World

March 2nd, 2020 2:48 am

SALEM It takes 15 seconds to check a childs vision, to determine if the child needs glasses or further eye care.

That 15 seconds can change a childs life. Without the screening, a child with vision problems will likely struggle in school, possibly becoming one of the nearly 20 percent of high school students across Oregon who dont graduate. In fact, a student who cant read at grade level by the end of third grade is 13 times less likely to graduate from high school.

With the screening, the child has a much greater chance to get the vision help that he or she needs, which can lead to success in school. That can lead the child beyond high school graduation to advanced degrees and successful careers, and it can set the child up to become one of your communitys future leaders.

The Oregon Lions Sight & Hearing Foundation can do this screening in 15 seconds with vision-testing equipment. In fact, the Foundation and its partners can screen an elementary school with 450 students in two hours. But the foundation needs help to screen every student across the state.

The Oregon Legislature has mandated that every elementary school student through age 7 across the state have a documented vision screening. The Legislature has incorporated funds within the Oregon Department of Education budget to cover screening for students up to their senior year in high school, with funding priority given to students pre-kindergarten through third grade.

The Oregon Department of Education has $2 million per year for the 2019-2020 and 2020-21 fiscal years for the screenings. The funds cover almost half of Oregons students through 12th grade, which means the Foundation needs further support from the communities it serves across Oregon.

Colt Gill, ODE director, participated in a recent vision screening in Salem and noted, Based on the results, some of the students will be heading to the eye doctor. That will set them on a path to learning and being successful in school so I really appreciate the work.

"Support for vision screening of Oregon students is basically joining the alliance of those working to improve our high school graduation rate here in Oregon, said Doug Thompson, executive director of the foundation. This is our future workforce so let's equip them now with the tools needed to be successful in life."

The recent Foundation screening at Liberty Elementary School in Salem showcased what the Foundation can do for elementary school students. Each class took their turns getting screened, with five Health Career students from Sprague High School using the hand-held screening machines to check the kids vision. Members of the South Salem Lions Club directed traffic, which moved quickly between the 15-second screenings.

The Foundation will report the results back to the Salem-Keizer school district which will work with the parents to get eye care to the students who need it.

Lynn Oehler, lead nurse for the district, said the machines can detect with 13 measures up to 8 conditions in each eye.

We have a pretty high rate of referrals for further care, but its mainly for conditions like astigmatism and other conditions that can be easily corrected, Oehler said. When we catch these conditions at a younger age, it absolutely helps the students learning process.

And its so much more efficient with the new technology, said Eric Richards, director of student services for the Salem-Keizer School District. Prior to the handheld machines, the foundation used eye charts, which dont allow for testing of nearly as many conditions.

This is a wonderful service and an important partnership with the Foundation, Richards said.

Brad King, one of the Foundations screening coordinators, said the Foundation is planning to screen an entire Portland-area high school with more than 2,800 students. He anticipated it will take an entire day but will be worth it to make sure any students with vision problems are identified.

With local financial support and partnership, the Oregon Lions Sight & Hearing Foundation can reach every student in the state. The Foundation is a 501c3 nonprofit, with a four-star ranking from Charity Navigator, and due to all administrative expenses being covered by its own long term investment fund every dollar raised by the organization directly supports its sight and hearing services.

OLSHF maintains a yearly review with the Better Business Bureau. The organization meets all 20 Standards for Charity Accountability and is a BBB Accredited Charity.

The Foundation can screen a child for $3.20, which is about 10 percent of the cost in an optometric office. The Department of Educations budget for screenings is enough to cover more than 281,000 students per year, kindergarten through 12th grade, not enough to cover all of Oregons 582,000 students.

Your support of the screenings would be used to offset any costs not covered by the state for screenings in your community, Thompson said. It would also assist with the costs associated with helping the students referred as needing a follow-up exam and new eyeglasses, to receive them.

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Full menu on tap for 10th Dining in the Dark | News, Sports, Jobs – Evening Observer

March 2nd, 2020 2:48 am

Dining in the Dark participants are led to their table at an event in recent years.

JAMESTOWN The Chautauqua Blind Association celebrates its 10th Annual Dining in the Dark on Friday, March 27 at the Chautauqua Harbor Hotel in Celoron, Dining in the Dark is a unique experience of eating without seeing.

Starting at 6 p.m., guests are invited to socialize, enjoy a cash bar and bid on silent auction items. Dinner seating begins at 6:30 p.m., where each guest will be blindfolded prior to being led by a sighted guide to their table to enjoy a three course meal.

During the event, the Chautauqua Blind Association will be announcing the Dr. Tim Grace Sight for Success Program. The Chautauqua Blind Association has been providing free vision screenings throughout Chautauqua County for over 40 years, says Lisa Goodell, executive director. We have historically identified 14% to 16% of the children we screen to be experiencing vision problems and we began to notice that those same children were identified year after year as not passing the CBA Vision Screening and not receiving treatment for their vision problems. To address this situation, we created the Sight for Success Program in 2019. Following the untimely death of Dr. Timothy Grace, many individuals made donations and memorials in Tims name, asking that their donation reflect Tims passion of improving the eye health of our community. The perfect partnership was formed by combining Dr. Graces vision of eye health and the Chautauqua Blind Associations Sight for Success Program. Therefore, at the 10th Annual Dining in the Dark, the CBA Sight for Success Program will become the Dr. Timothy Grace Sight for Success Program.

Inaugurated in 2017, the Louise Tefft Award has been given to community members who have greatly supported the Chautauqua Blind Associations mission of enabling visually impaired people to be active members of their community and to provide education and services to prevent vision loss.

Louise was a client of CBA for over 25 years and attributes all of the services she received from CBA to the fact that she was able to remain independent, in her home, for her entire life, says Goodell. This years award recipient will be Kathy and Tim Grace. Kathy supported CBA for many years, including being an instrumental part in the Chautauqua Blind Associations fundraising efforts. She helped CBA get involved with the JCC Occupational Therapy Assistant Program which provided sighted guides since inception of Dining in the Dark. Kathy also conceptualized the idea of the Wine and Art Auction as a second fundraiser and worked tirelessly on both events to make them successful. Dr. Tim Grace has supported the mission of CBA for countless years both financially and through advocacy for the blind and visually impaired.

The one of a kind sensory adventure offers guests the opportunity to have a dining experience without the use of their sight! It is more than just a meal; it is a journey of the senses that will make you re-evaluate your perception of taste, smell and touch all in the dark. We are very proud that this annual fundraiser and awareness event has supported our Youth Vision Screening Program, says Goodell. Ten years ago, when I presented this idea to our Board of Directors, many questioned whether it would be well-received. They supported my idea and for 10 years now, it has provided funds to screen over 20,000 children.

Reservations are $65 per person and include a three course meal. Dinner options are a 6 oz filet mignon, stuffed chicken breast, miso glazed salmon and vegetable lasagna. Reservations are appreciated by Wednesday, March 18 and can be made online at chautauquablind.org or by calling 716-664-6660.

Dining in the Dark offers community partners and businesses a great way to support the Chautauqua Blind Association while receiving exceptional visibility and recognition. Sponsorships are available to fit any budget and include dinner reservations. Program listings are available for $100.

For sponsorship information, call Lisa Goodell at 664-6660. Sponsorship deadline is March 18. A special thank you to the 2020 event sponsors which include UPMC Chautauqua, HomeTown Insurance, Weber Knapp, Chautauqua Chemical and Ahlstrom Schaefer.

Donations for the silent auction are appreciated and can be dropped off up until the day of the event at The Chautauqua Blind Association, located at 510 W. Fifth St., Jamestown.

All event proceeds will support the Youth Vision Screening Program. In 2019, the Chautauqua Blind Association screened over 4,000 children under the age of 6. Over 600 of these children were determined to have undiagnosed vision problems. These children are referred to area eye care professionals for further evaluations and/or treatment. The Chautauqua Blind Associations goal is to provide this program free of charge to area children. The funds raised at Dining in the Dark make sure that any child in Chautauqua County as access to this service.

If unable to attend but interested in supporting the mission of the Chautauqua Blind Association, a tax-deductible donation can be made online at chautauquablind.org or by sending a check to the Chautauqua Blind Association located at 510 W. 5th Street, Jamestown, NY.

For almost 100 years, the Chautauqua Blind Association has been providing Chautauqua and Cattaraugus Counties with Vision Rehabilitation Services, and Orientation and Mobility instruction to blind and legally blind residents. These services include low vision rehabilitation, pre-school vision screenings, advocacy and education. Detecting vision changes early and effectively is crucial in providing necessary treatment and rehabilitation in order for a visually impaired person to live more efficiently and independently. The Chautauqua Blind Association has been a local resource for the visually impaired, regardless of financial ability. The Chautauqua Blind Association is a United Way Partner.

For more information about the Chautauqua Blind Association or to learn more about upcoming events, visit Chautauquablind.org or call 664-6660. The Chautauqua Blind Association is a 501 (c) 3 not-for-profit charitable organization.

The worst weekly slide since 2008, U.S. stocks dropped approximately 13% as of Friday afternoon. While not good ...

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YOUR HEALTH: A cancer that robs children of their sight – WQAD.com

March 2nd, 2020 2:48 am

A doctor was able to save Ruby's eyes and found a new way to detect an aggressive childhood cancer

LOS ANGELES Retinoblastoma is an aggressive cancer in children that robs them of their sight.

Now doctors have a new way to detect it and that may end up saving the eyesight of children facing a life of blindness.

Ruby Chan was born three months premature.

Three months later she was diagnosed with a life-threatening, sight-stealing disease.

"She wasn't even supposed to be born yet at this point and they were like, we'd like to take her eye out tomorrow," recalled Ruby's mother, Nellie Chan.

Ruby was diagnosed with retinoblastoma, a cancer of the eye where tumors develop behind the retina.

There are two main types of retinoblastoma, intraocular and extraocular. Intraocular means that the cancer is in one or both eyes but has not spread to other parts of the body, while extraocular means it has spread.

Instead of having her eye removed, Ruby's parents decided to do their research.

They foundLos Angeles Children's Hospital ocular oncologist Jesse Berry who developed a liquid biopsy for children like Ruby that answers many of the unknowns.

"How likely is it that an eye will respond to therapy and how likely is it that an eye might have continued recurrence even in spite of treatment?" asked Dr. Berry.

Using a needle, a pea-sized amount of liquid is extracted.

"Instead of placing the needle directly into the tumor, we actually extract a very little bit of liquid called the aqueous humor from the front of the eye."

In a research setting only, that liquid is tested for DNA molecules that are shed from the tumor cells.

Doctors can predict with 75% to 85% accuracy if the tumor will respond to standard treatments.

PARENTS, BEWARE:The best detection may be you! When looking at your child's photograph, instead of the typical red eye from flash photography in a child with retinoblastoma, the pupil will appear white.

There has been much research conducted in the past few decades that have led to higher cure rates and fewer side effects.

Researchers have learned that using focal treatments like laser therapy kills tumor cells more precisely. They have begun to examine ways of taking advantage of the gene changes in the cells of retinoblastoma.

Ruby had chemo to reduce the size of the tumors and more than 70 laser procedures to burn the edges of them.

Tumors in Ruby's left eye have not impacted her sight.

The original tumor in Ruby's right eye has left her with 25% of her vision.

With the help of targeted therapies they're hoping to save both of Ruby's eyes.

Children's Hospital Los Angeles is now running a multicenter trial.

Following strict research protocols, surgeons from all over the country can take a sample of the aqueous humor and send it to Dr. Berry and her team for evaluation.

If this story has impacted your life or prompted you or someone you know to seek or change treatments, please let us know by contacting Jim Mertens atjim.mertens@wqad.comor Marjorie Bekaert Thomas atmthomas@ivanhoe.com.

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Call for Ideas: Innovative technology to reduce visual impairment & blindness – BSA bureau

March 2nd, 2020 2:48 am

Call for Hospitals and Clinics who are part of the Global Sight Initiative through a commitment of $250k to spark innovation in technology

US based Seva Foundation has announced a call for ideas to identify innovative technology-based solutions to improve eye care delivery. It iscommitting $250k to spark innovation in technology to help people see.

This call for ideas is limited to hospitals and clinics that are currently an active part of the Global Sight Initiative. The Global Sight Initiative, a network of more than 100 hospitals around the world, collaborates to accelerate the development of high quality, high volume, sustainable eye care services through innovation, training, mentoring, research, and advocacy.

Globally, at least 2.2 billion people have a vision impairment, and of these, at least 1 billion people have a vision impairment that could have been prevented or is yet to be addressed. A recent study in theLancet Global Healthprojected a three-fold increase in global blindness by 2050. Reversing this trend will require innovation and identifying creative uses of technology to multiply effectiveness in providing eye care to people who need these services.

Seva seeks innovative, locally applicable solutions that leverage technology to extend the reach and impact of eye care services.

"We know that there are a lot of innovative ideas that our partner eye clinics want to try but just don't have the initial capital investment to get their idea off the ground. With these funds, Seva can promote these great ideas and further our mission to end avoidable blindness", says Kate Moynihan, Seva Foundations Executive Director.

Qualifications

Must be a hospital or eye clinic that is actively part of Sevas Global Sight Initiative.

Apply

Seva will release awards of up to $50,000 per award and announce the recipients by the end of Q2 2020. Interested applicants may submit a 1-2 page Letter of Intent (LOI) that clearly outlines your organizations ideas on how to use technology to reduce visual impairment and blindness.

Key information to include:

Submissions

Submit LOI via email with a subject line: Your Organization Name Call For Ideas Submission.LOIs must be received by 11:59 pm (Pacific Time) on 25 March 2020.

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Call for Ideas: Innovative technology to reduce visual impairment & blindness - BSA bureau

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Dancing On Ice star Libby Clegg’s heartbreaking prognosis for her eye condition – Mirror Online

March 2nd, 2020 2:48 am

Paralympic champion Libby Clegg has made it through to the semi-final of Dancing On Ice after the judges unanimously saved her.

Libby was in the skate off with Coronation Street star Lisa George.

While Lisa was devastated to be leaving the show, she was thrilled she had reached that stage in the competition.

She told host Holly Willoughby: "I'm made up I got this far. I've had so much fun. Thank you Tom!"

Libby has made history on the hit ITV show as the first blind celebrity to take part.

Although the medal winning sprinter actually claims her condition gives her an advantage on the ice.

She explained: "I cant see so dont feel dizzy or nauseous when I do spins.

Although I cant watch my partner demonstrate moves on the ice, I have great hearing so listen to his skates and try to mimic the clicks, scrapes and foot placements I hear.

I count the number of strides it takes to reach the barrier of the rink so I dont just fly into it. And, touch wood, Ive not had any injuries. I dont suffer things other people do.

Libby's incredible peformances have now earned her a place in the semi-final alongside Perri Kiely and Joe Swash.

The athlete, who has been awarded an MBE for her contributions to athletics and charity, has Stargardt's Macular Dystrophy disease, which she was diagnosed with when she was nine.

She has previously described it as "like looking at a pixelated computer screen or a scrunched-up firework".

Libby is registered blind and now only has limited vision in her left eye.

Heartbreakingly, her condition is deteriorating and there is no treatment for Stargardt's Macular Dystrophy, which means she could one day lose what's left of her vision.

Libby said: "Im at the age where my sight should be stabilising but its still deteriorating.

"Things will never go black, but I dont know yet exactly what I will be able to see."

But Libby, who has a baby son, Edward, with her partner and fellow Paralympian, Dan Powell, is determined her condition won't hold her back.

There is also a 50/50 chance her son will inherit the same condition as his mum - but that's something Libby is prepared for.

She said: "If he does have a sight condition, it's not that I would expect him to become a Paralympic champion or anything, but there are options

"There are a lot of things you can do that people tend to restrict you and not think you can.

"He could go into anything. If he can't see, we're not going to treat him any differently anyway."

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Dancing On Ice star Libby Clegg's heartbreaking prognosis for her eye condition - Mirror Online

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Eyecarrot Announces Vision Training Partnership Agreement with the Dallas Stars – InvisionMag

March 2nd, 2020 2:48 am

(PRESS RELEASE) Prevent Blindness, the nations oldest eye health and safety nonprofit organization, has declared March as Workplace Eye Wellness Month. According to the Centers for Disease Control and Prevention (CDC), approximately 2,000 U.S. workers sustain a job-related eye injury that requires medical treatment a day. About one-third of the injuries are treated in hospital emergency departments, and more than 100 of these injuries result in one or more days away from work.

For those who work outside an office setting, Prevent Blindness warns of common causes for eye injuries and urges everyone to wear the proper eye protection for risks that include:

The type of safety eye protection that Prevent Blindness recommends depends on the hazards in the workplace. For areas that have particles, flying objects, or dust, safety glasses with side protection (side shields) should be worn. Goggles should be worn for anyone working with chemicals. And, for those working near hazardous radiation (welding, lasers, or fiber optics) special-purpose safety glasses, goggles, face shields, or helmets designed for that task should be worn.

Those who work within an office setting (working with computers and other digital devices) are at higher risk for digital eye strain. According to the American Academy of Ophthalmology (AAO), eye strain symptoms include dry eyes, blurry vision, tearing or watery eyes, and headache. The cause of digital eye strain is that people blink less when they stare at digital devices. The AAO adds that normally, humans blink around 15 times per minutebut this blink rate can be cut in half when staring at screens or doing other near work activities (like reading).

Prevent Blindness recommends placing a digital screen 20 to 26 inches away from the eyes and slightly below eye level. Also, adjust lighting to lower glare and harsh reflections. More tips may be found at here.

Recognizing your eye health and safety needs within the workplace, and taking all the necessary steps to protect vision, can help us all to continue to protect healthy eyesight for years to come, said Jeff Todd, president and CEO of Prevent Blindness.

For more information about workplace eye health topics, call Prevent Blindness at (800) 331-2020 or visit here.

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Oprah Falls Onstage at 2020 Eyesight Tour Clearly show and laughs – gotech daily

March 2nd, 2020 2:48 am

Even Oprah Winfrey It can be shot down But she will get up all over again, and you will by no means preserve her down.

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The famed tv mogul took the phase at her 2020 Vision: Your Lifestyle in Emphasis Tour display at the Discussion board in the Los Angeles space on Saturday, though ironically speaking, about the thought of preserving stability in lifetime.

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"This is my definition of what wellness implies to me. This is my definition, not yours, just an plan, due to the fact you will determine it for yourself. Wellness for me usually means that all the things in harmony and balance does not mean anything is the identical. or they are at peace at all occasions, "claimed Winfrey, in advance of shedding his stability, falling and landing on his aspect just before sitting down and obtaining up.

She was unharmed and laughed at the incident, as was the audience.

"It really is superior to be chatting about stability and fall," he mentioned afterwards, triggering laughter in the group. "Jesus, you are so amusing! Lord. You're so funny."

Winfrey then asked anyone to convey his new sneakers and transformed his shoes for white types.

Saturday's present functions famed guests Jennifer Lopez.

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High blood pressure symptoms: The sign in a persons eyes that could signal the condition – Express

March 2nd, 2020 2:48 am

High blood pressure reads as 140/90mmHg on a blood pressure test. Without one of those machines, how could you know you have the deadly health condition? Theres a sign in your eye that could indicate you have the health issue.

An optometrist an eye doctor from America, Dr William White, says that while he does his routine examination on his patients, hes always on the look out for clues indicating somebody is suffering from high blood pressure.

We [optometrists] can see changes due to vascular conditions caused by hypertension, he said.

Hypertension is the medical term given to high blood pressure.

Underpinning this statement, a 2013 study published in the journal Hypertension focused its attention on 2,900 patients who showed signs of hypertensive retinopathy (blood vessel damage in the eyes).

After 13 years, they found those who had a mild form of hypertensive retinopathy had a 35 percent greater risk of stroke.

That risk increased to 137 percent with those who displayed moderate to severe hypertensive retinopathy.

Dr White said: High blood pressure has a cumulative effect. If it's uncontrolled over years, it's going to cause damage later in life."

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High blood pressure symptoms: The sign in a persons eyes that could signal the condition - Express

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Vision Expo East 2020 to Take Place as Planned March 26-29 – InvisionMag

March 2nd, 2020 2:48 am

(PRESS RELEASE) Prevent Blindness, the nations oldest eye health and safety nonprofit organization, has declared March as Workplace Eye Wellness Month. According to the Centers for Disease Control and Prevention (CDC), approximately 2,000 U.S. workers sustain a job-related eye injury that requires medical treatment a day. About one-third of the injuries are treated in hospital emergency departments, and more than 100 of these injuries result in one or more days away from work.

For those who work outside an office setting, Prevent Blindness warns of common causes for eye injuries and urges everyone to wear the proper eye protection for risks that include:

The type of safety eye protection that Prevent Blindness recommends depends on the hazards in the workplace. For areas that have particles, flying objects, or dust, safety glasses with side protection (side shields) should be worn. Goggles should be worn for anyone working with chemicals. And, for those working near hazardous radiation (welding, lasers, or fiber optics) special-purpose safety glasses, goggles, face shields, or helmets designed for that task should be worn.

Those who work within an office setting (working with computers and other digital devices) are at higher risk for digital eye strain. According to the American Academy of Ophthalmology (AAO), eye strain symptoms include dry eyes, blurry vision, tearing or watery eyes, and headache. The cause of digital eye strain is that people blink less when they stare at digital devices. The AAO adds that normally, humans blink around 15 times per minutebut this blink rate can be cut in half when staring at screens or doing other near work activities (like reading).

Prevent Blindness recommends placing a digital screen 20 to 26 inches away from the eyes and slightly below eye level. Also, adjust lighting to lower glare and harsh reflections. More tips may be found at here.

Recognizing your eye health and safety needs within the workplace, and taking all the necessary steps to protect vision, can help us all to continue to protect healthy eyesight for years to come, said Jeff Todd, president and CEO of Prevent Blindness.

For more information about workplace eye health topics, call Prevent Blindness at (800) 331-2020 or visit here.

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Vision Expo East 2020 to Take Place as Planned March 26-29 - InvisionMag

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Biogen teams up with Sangamo in gene therapy deal worth up to $2.7B – MedCity News

March 2nd, 2020 2:46 am

A large biotech is partnering with a firm developing cell and gene therapies on treatments for neurological diseases like Alzheimers and Parkinsons.

Cambridge, Massachusetts-based Biogen said Thursday afternoon after markets closed that it had partnered with Brisbane, California-based Sangamo Therapeutics in a deal that could be worth up to $2.7 billion. The partnership will initially focus on two preclinical Sangamo gene therapy candidates ST-501 for tauopathies such as Alzheimers and ST-502 for synucleinopathies like Parkinsons disease, plus an undisclosed neuromuscular target. It also includes exclusive rights for up to nine other undisclosed neurological targets.

Biogen will pay Sangamo $350 million upfront, which includes a license fee and equity investment, while Sangamo will be eligible for up to $2.37 billion in milestone payments, plus royalties.

Shares of Sangamo were up more than 28% on the Nasdaq after markets opened Friday. The company had also announced its fourth quarter and full year 2019 financial results. Biogens shares were down 2.6%.

Sangamo had reached out to multiple companies in a competitive process. While declining to say how many companies the biotech had spoken to, Sangamo head of corporate strategy Stephane Boissel said in a phone interview that it had put together multiple term sheets.

Its a combination of economics, but also the expertise of that partner in that particular field, Boissel said, referring to why the company had chosen Biogen. Biogen, in the pharma world, is probably the best franchise when it comes to neurology.

Adrian Woolfson, Sangamos executive vice president for research and development, said in the same call that it was also because of an appreciation for Biogens enthusiasm and energy.

I think its fair to say we had a very good chemistry with them at a personal level when we went to meet with them in Boston, and we seemed to get along very well, Woolfson said.

Sangamo has existing partnerships with a number of other firms, including Pfizer and Gilead Sciences.

Biogens moves into Alzheimers disease have not been without controversy. The company plans to file for Food and Drug Administration approval of aducanumab, a monoclonal antibody targeting the amyloid beta protein that has long dominated Alzheimers research. The company initially halted the Phase III development program for the drug when it was predicted to fail, but revived it when a post-hoc analysis indicated potential efficacy. Investors have remained skeptical.

Still, that did not come up in the minds of Sangamos executives, Boissel said. While emphasizing that he could not compare the two companies approaches, Woolfson added that gene therapies are potentially better ways to address neurological diseases like Alzheimers because they can switch off genes completely rather than being limited to taking out specific proteins, as monoclonal antibodies are.

ST-501 targets tau, another protein that has been researched as a potential therapeutic target in Alzheimers. ST-501 and ST-502 use adeno-associated viral vectors to deliver zinc finger protein transcription factors (ZFP-TFs), a form of gene therapy that Sangamo said in its quarterly earnings presentation is ideally suited to neurological disorders due to its ability to up- or down-regulate gene expression.

Boissel did not disclose specific timelines for ST-501 and ST-502, but noted that the next steps in their development will be preclinical studies to enable them to enter the clinic.

Photo: John Tlumacki, The Boston Globe, via Getty Images

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Biogen teams up with Sangamo in gene therapy deal worth up to $2.7B - MedCity News

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Retinal Gene Therapy Trial Posts Positive Result – Alzforum

March 2nd, 2020 2:46 am

24 Feb 2020

Another gene therapy for a central nervous system disorder has posted positive results. The Phase 1/2 trial enrolled 18 men with X-linked retinitis pigmentosa (RP), a disease of retinal degeneration that leads to blindness. Robert MacLaren of the University of Oxford led the study, published February 24 in Nature Medicine.

The dose-escalation trialtested six doses; the therapy consisted of an adeno-associated virus 8 expressing a normal copy of the RP GTPase gene. Seven patients saw improvements in their vision that endured for the six-month duration of the trial. Inflammation within the eye cropped up at the higher doses, which may have temporarily blurred therapeutic effects in some patients.

Interest in using gene-based therapy for AD and other neurodegenerative disorders has grown ever since such a therapy was approved for treating spinal muscular atrophy (SMA) in babies and toddlers, and the field is now looking to learn from trials of other nervous system disorders (Nov 2019 news;Dec 2019 news).

X-linked RP is caused by mutations in the RP GTPase regulator (RPGR) gene. The mutations trigger degeneration of photoreceptors starting in childhood. No treatments exist. Recent approval of a gene therapy for another retinal disorderRPE65-related retinal degenerationsuggests retinal gene therapy could work (Russell et al., 2017).

However, the RPGR gene has confounded scientists, as it contains a repetitive, purine-rich stretch that undergoes alternative splicing. Tinkering with the sequence has boosted fidelity and stability of the gene, and conferred therapeutic benefits in animal models of the disease (Fischer et al., 2017).

In this trial, each of the 18 men, who were between 22 and 50 years old, had severe retinal degeneration. They were recruited in six cohorts of three patients each, who received increasing doses of the viral therapy. The participants received an injection of the virus into their subretinal space; they were then monitored for safetythe trials primary outcomeand tested for vision and retinal sensitivity for six months.

Across the cohorts, 55 adverse events occurred, all mild. Seven out of nine patients on the three highest doses experienced mild retinal inflammation, which was corrected by oral corticosteroids. In all, the trial met its primary safety endpoint.

Seven out of 12 patients receiving one of the top four doses had visual gains in the treated eye. This was gauged by retinal microperimetry, a map of the quality of light perceived across the retina. The improvements started at one month and continued at the six-month follow-up. The researchers proposed that inflammation in the top three dose cohorts may have offset visual improvements in some patients.

The trial was not designed to draw conclusions about efficacy. The researchers speculated that the therapys effectiveness will boil down to the stage of retinal degeneration, vector dose, and any interfering effects of inflammation. The second phase of the study will compare two doses to placebo.

Though the eyes are not strictly the brain, retinal therapy can be considered as part of the revitalization of gene-therapy approaches for neurodegenerative diseases. AAV-based expression of survival motor neuron 1 has improved life for those with SMA, but the tricky aspects of RPGE gene expression, and the inflammatory response that cropped up at higher doses, point to potential challenges other gene therapies may have to overcome (Nov 2016 news; Mendell et al., 2017).Jessica Shugart

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