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Global Stem Cell Cartilage Regeneration Market Current Status, Historical Analysis and Forecast 2019 to 2028 – Biz News Wire

December 8th, 2019 11:51 am

The Stem Cell Cartilage Regeneration Market 2019-2028 Analytical Reporthasrecently published byMarketresearch.bizto its massive repository. The research report has been summarized with informative and technical details of the dynamics of the market. It has been compiled by using some significant research methodologies such as primary and secondary research techniques.

The Stem Cell Cartilage Regeneration report also elaborates on the factors which are fueling or hampering the growth of the market. It gives more focus on recent trends and technologies which have been adopted by top-level industries are elaborated to get proper directions for the businesses and boosting the performance of the companies.

The Stem Cell Cartilage Regeneration report includes a comprehensive overview of the global Stem Cell Cartilage Regeneration market, which also sheds light on the scope of the product. The analysts have categorized the market into different segments on the basis of some significant market segments such as stem cell type, treatment, end user, and region. After a careful analysis of the market as per these categories, the analysts have revealed the market and production shares of several segments for the review period.

Fill Out Details to Receive Free Sample Report Copy Here @https://marketresearch.biz/report/stem-cell-cartilage-regeneration-market/request-sample

Prominent Top Key Vendors of Stem Cell Cartilage Regeneration Report:-Theracell (Laboratories), Orthocell Limited, Xintela AB (publ), CellGenix GmbH, Merck KGaA, Osiris Therapeutics Inc, BioTissue Technologies GmbH, Vericel Corporation, Smith & Nephew plc, EMD Serono Inc

The geographical segmentation of the global Stem Cell Cartilage Regeneration market allows users of the report to formulate a multilevel perspective of the market in terms of regional prominence and global expansion plans. Additionally, it throws light on leading industry key players across the global regions such as North America, Latin America, Asia-Pacific, Europe, The Middle East, and Africa. Different internal and external factors have been mentioned, which are responsible for fueling or restraining the progress of the companies. Informative information regarding the challenges faced by the industries and approaches adopted by them to overcome those threats has been included.

Geographical Segmentation:-

1.North America(United States, Canada)

2.Europe(Germany, Spain, France, UK, Russia, and Italy)

3.Asia-Pacific(China, Japan, India, Australia, and South Korea)

4.Latin America(Brazil, Mexico, etc.)

5.The Middle East and Africa(GCC and South Africa)

Stem Cell Cartilage Regeneration Market Segmentation:-

Segmentation by stem cell type:

Hematopoietic Stem Cells (HSCs)Pluripotent Stem Cells (iPSC/ESCs)Mesenchymal Stem Cells (MSCs)Segmentation by treatment:

MicrofractureOsteochondral TransplantAutologous Chondrocyte ImplantationStem Cell InjectionsSegmentation by end user:

Hospitals & ClinicsAmbulatory Surgical Centers

If you have any special requirements, please let us know and we will offer you the report as per your requirements.

Ask our Industry Experts @https://marketresearch.biz/report/stem-cell-cartilage-regeneration-market/#inquiry

The Key Points of this Stem Cell Cartilage Regeneration Market Report are:

1. To survey and forecast the market size share of Stem Cell Cartilage Regeneration, in terms of value and volume.

2. Provide detailed information concerning the Stem Cell Cartilage Regeneration major factors (opportunities, drivers, restraints, and industry-specific challenges) influencing the growth of Stem Cell Cartilage Regeneration market.

3. To study the future outlook and prospects for the Stem Cell Cartilage Regeneration market with Marketing Price (Price and Margin, Factors of Price Change, Manufacturers Gross Margin Analysis)

4. To analyze the global key regions Stem Cell Cartilage Regeneration market potential and advantage, opportunity and challenge, restraints and risks.

5. Detail Profile of the dominant players and Stem Cell Cartilage Regeneration comprehensively analyses their market status in terms of ranking and core capability along with in-depth the Stem Cell Cartilage Regeneration competitive landscape for the market leaders.

6. Study competitive developments like partnerships and joint ventures, Stem Cell Cartilage Regeneration new product developments, expansions and research and development of Stem Cell Cartilage Regeneration market.

Finally, it focuses on the beneficial opportunities for growth, which promotes a way of turning a business idea into the venture. In addition to this, it gives a detailed description of top driving factors such as Stem Cell Cartilage Regeneration Market for the studies. Restraints are also provided to study the risk factors in front of businesses.

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Revised genetic index will help boost longevity – The Scottish Farmer

December 8th, 2019 11:50 am

The new dairy proofs boast a revamped genetic index for cattle lifespan, enabling milk producers to identify bulls whose offspring will be more healthy and productive will help predict more accurate longevity in additional days rather than lactations.

Previously expressed in lactations which meant very little difference between the best and worst animals, the indexs scale has now been increased to approximately -305 to +305 days enabling producers to make more precise decisions.

Marco Winters, head of animal genetics with AHDB Dairy, said: The new figures give producers a more meaningful prediction of the extra lifetime expected from a bulls daughters and make a greater distinction between individual bulls.

Lifespan reflects many contributory factors, ranging from fertility and somatic cell counts to legs, feet and udder conformation. The index has a strong correlation with an animals average daily lifetime yield, which is a key contributor to its lifetime profitability.

Producers have made progress in their cows lifespan, which has steadily increased since LS was included in AHDBs Profitable Lifetime Index (PLI) in 1999 (see graph).

By helping to differentiate individual sires and moving to a larger and more meaningful scale, we feel confident we can further increase genetic progress for this trait, so cutting a herds replacement rate and its costs of heifer rearing, he said.

Lifespan Index Q and A

1. Why is lifespan so important?

It is estimated to cost more than 1800 to rear a Holstein dairy heifer from birth to the point of calving. Around 70% of farmers pay back this investment during the animals second lactation. More precisely, the average number of days at which payback occurs is a staggering 530 after first calving! Any measures which can therefore be taken to extend an animals productive life beyond this point will help improve its return on the large initial investment. Using the Lifespan Index when breeding cattle can help producers improve their herds survival rates by hundreds of days.

2. How does the new scale work?

The new scale for Lifespan Index (LS) will run from around -305 days to +305 days, with positive figures being desirable. Daughters of a +305 Lifespan Index bull are predicted to live, on average, 305 days longer than daughters of a sire whose index is zero. Equally, they are predicted to live 610 days longer than daughters of a -305 LS bull. As with all UK genetic indexes, zero represents the average.

3. How are Lifespan Indexes calculated?

The Lifespan Index is calculated from actual daughter survival, when that information is available. When it is not, it is either calculated from the animals own genotype (if it has a genomic index), or from predictive traits such as type traits (legs, feet and udders) and Somatic Cell Count Index, all of which are correlated with lifespan. Where necessary, information on ancestors lifespan will also be included in the calculation of the index. This and all other predictors will diminish in their importance as the animal acquires progeny lifespan information of its own.

4. Arent many animals culled for low production rather than survivability?

An important feature of the Lifespan Index is that it predicts involuntary rather than voluntary culling. As there is such a strong relationship between milk production and lifespan (because low producers are generally culled earlier from the herd), Lifespan Index is corrected for milk production. This correction ensures the index is more a measure of daughters ability to survive than of their failure to produce milk, which itself would be apparent from Predicted Transmitting Abilities (PTAs) for production.

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Revised genetic index will help boost longevity - The Scottish Farmer

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Purdue taking part in life-long study of dogs health and aging – WTHR

December 8th, 2019 11:50 am

WEST LAFAYETTE, Ind. (WTHR) Researchers are looking for America's oldest dog.

They don't want to teach him new tricks, but they are hoping he could teach them a few things.

And your dog could be part of their life-long scientific study that's looking to learn from pets nationwide.

More than 40 scientists and researchers from across the United States including one from Purdue University are looking for dogs to participate the national study of the general health and wellness of dogs.

The Dog Aging Project will be looking at dogs of all breeds and mixes from across the nation. This is the first major longitudinal study involving dogs, and it's scheduled to last at least 10 years.

We are going to look at a lot of different aspects of dogs lives that affect their health and longevity, says Audrey Ruple, a veterinary epidemiologist at Purdue.

Dogs are good models for humans, she says. They have similar genetics, share our environment, and they also have similar diseases and health issues. We will be asking, How do dogs age healthfully? in order to help better understand how we can age healthfully, too.

Dogs of all age ranges, breeds and sizes are eligible to participate in the study. Owners go online to register their dogs, then create a personal profile to track health, home life, diet, environment and lifestyle.

Dogs will need to make regular veterinarian visits every year. If a dog is assigned to a specific group, the owners may get a kit for their veterinarian to collect blood, urine or other samples during the annual visit.

Participation is voluntary and there is no cost to participate.

Its important to get dogs from all parts of the U.S. because of the different environmental factors present, Ruple said. And were trying to find the oldest dog in America, as well.

All dogs registered will be eligible to participate in various studies. The group conducted a soft launch with 4,500 dogs registered earlier this fall. Recently, the researchers reached 75,000 dogs for the study.

Our study population just keeps growing and growing and growing, Ruple said.

Researchers hope to find out more details on how genetics, demographics and environmental factors such as chemical exposures and noise pollution impact health and longevity.

Ruple says one goal of the study is to not just improve the health and longevity of dogs, but also extend those findings to improve human health. By studying aging in dogs, we hope to learn how to better match human health span to life span so that we can all live longer, healthier lives, Ruple said.

Funding for the Dog Aging Project comes from the National Institute of Aging, a part of the National Institutes of Health, as well as from private donations.

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Purdue taking part in life-long study of dogs health and aging - WTHR

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Fascinating Study Finds That Stressed Out Baby Worms Tend to Live Longer – ScienceAlert

December 8th, 2019 11:50 am

Scientists researching a key aspect of biochemistry in living creatures have been taking a very close look at the tiny Caenorhabditis elegans roundworm. Their latest results show that when these nematodes get put under more biochemical stress early in their lives, they somehow tend to live longer.

This type of stress, called oxidative stress - an imbalance of oxygen-containing molecules that can result in cellular and tissue damage - seems to better prepare the worms for the strains of later life, along the same lines as the old adage that whatever doesn't kill you, makes you stronger.

You might think that worm lifespans have no bearing on human life. And surely, until we have loads more research done in this field, it would be a big leap to say the same principles of prolonging one's lifespan might hold true for human beings.

But there's good reason to put C. elegans through the paces. This model organism has proven immensely helpful for researchers trying to better understand key biological functions present in worm and human alike - and oxidative stress is one such function.

The little wriggly creatures are known to have significant variations in their lifespan even when the whole population is genetically identical and grows up in the exact same conditions. So the team went looking for other factors that affect C. elegans' longevity.

"The general idea that early life events have such profound, positive effects later in life is truly fascinating," says biochemist Ursula Jakob from the University of Michigan.

Jakob and her colleagues sorted thousands of C. elegans larvae based on the oxidative stress levels they experienced during development this stress arises when cells produce more oxidants and free radicals than they can handle. It's a normal part of the ageing process, but it's also triggered by exercise and a limited food supply.

One way to measure this stress is by the levels of reactive oxygen species (ROS) molecules an organism produces - simply put, this measurement indicates the biochemical stress an organism is under. In the case of these roundworms, the more ROS were produced during development, the longer their lifespans turned out to be.

(University of Michigan)

To explain how this effect of ROS might come about, the researchers went looking for changes in the worms' genetic regulation, specifically those genes that are known to be involved in dealing with oxidative stress.

While doing so, they detected a key difference - the nematodes exposed to more ROS during development appeared to have undergone an epigenetic change (a gene expression switch that can happen due to environmental influences) thatincreased the oxidative stress resistance of their body's cells.

There are still a lot of questions to answer, but the researchers think their results identify one of the stochastic or random influences on the lifespan of organisms; it's something that has been hypothesised in the field of the genetics of ageing. And down the line, it may turn out to be relevant for ageing humans, too.

"This study provides a foundation for future work in mammals, in which very early and transient metabolic events in life seem to have equally profound impacts on lifespan," the researchers conclude.

The study has been published in Nature.

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Fascinating Study Finds That Stressed Out Baby Worms Tend to Live Longer - ScienceAlert

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Dairy lifespan index trait updated to improve accuracy – FarmersWeekly

December 8th, 2019 11:50 am

The genetic index that predicts dairy cattle lifespan has been revamped to make it more accurate and indicate longevity in additional days rather than lactations.

The change will help dairy cattle breeders identify bulls whose offspring should live more healthy, productive and longer lives in their herds.

Previously, lifespan was expressed in lactations, which meant very little difference between the best and worst animals.

The indexs scale has now been increased to about -305 to +305 days, enabling producers to make more precise decisions.

The update to the lifespan index takes effect from the December AHDB Dairy proof run, which will be published this week (3 December).

See also:How to achieve an efficient dairy breeding programme

Marco Winters, head of animal genetics with AHDB Dairy, said: The new figures give producers a more meaningful prediction of the extra lifetime expected from a bulls daughters and make a greater distinction between individual bulls.

Lifespan reflects many contributory factors, ranging from fertility and somatic cell counts to leg, feet and udder conformation. The index has a strong correlation with an animals average daily lifetime yield, which is a key contributor to its lifetime profitability.

By helping to differentiate individual sires and moving to a larger and more meaningful scale, we feel confident we can further increase genetic progress for this trait, so cutting a herds replacement rate and its costs of heifer rearing, Mr Winters added.

Why is lifespan so important?

It is estimated to cost more than 1,800 to rear a Holstein dairy heifer from birth to the point of calving. About 70% of farmers pay back this investment during the animals second lactation.

More precisely, the average number of days at which payback occurs is a staggering 530 after first calving.

So any measures that can extend an animals productive life beyond this point will help improve its return on the large initial investment.

Using the lifespan index when breeding cattle can help producers improve their herds survival rates by hundreds of days.

How does the new scale work?

The new scale for lifespan index will run from about -305 days to +305 days, with positive figures being desirable.

Daughters of a +305 lifespan index bull are predicted to live, on average, 305 days longer than daughters of a sire whose index is zero.

Equally, they are predicted to live 610 days longer than daughters of a -305 lifespan index bull. As with all UK genetic indexes, zero represents the average.

How are lifespan indexes calculated?

The index is calculated from actual daughter survival, when that information is available.

When it is not, it is either calculated from the animals own genotype (if it has a genomic index), or from predictive traits such as type traits (legs, feet and udders) and somatic cell count index, all of which are correlated with lifespan.

Where necessary, information on ancestors lifespan will also be included in the calculation of the index.

This and all other predictors will diminish in their importance as the animal acquires progeny lifespan information of its own.

Arent many animals culled for low production rather than survivability?

An important feature of the lifespan index is that it predicts involuntary rather than voluntary culling.

As there is such a strong relationship between milk production and lifespan (because low producers are generally culled earlier from the herd), lifespan index is corrected for milk production.

This correction ensures the index is more a measure of daughters ability to survive than of their failure to produce milk, which itself would be apparent from predicted transmitting abilities (PTAs) for production.

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Dairy lifespan index trait updated to improve accuracy - FarmersWeekly

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What’s the minimum amount of exercise I need to do to see results? – Richmond Register

December 8th, 2019 11:50 am

It's that time of year with Thanksgiving just over and Christmas approaching that many of us tend to cut back on our exercise routines in order to enjoy the holidays with family and friends. So how much and how often do you need to work out to improve your health and fitness? There's not a simple answer to that question but there are several guidelines to follow that have been found through research.

First of all, it's important to accept that when it comes to moving, something is always better than nothing. Every rep, set and second that you move will get you much closer to your goals. Many research studies, most recently an August 2019 review published in the British Medical Journal, have shown that any exercise comes with a lower risk of early death. Interestingly, researchers have noted that the dose-response relationship between exercise and longevity is non-linear, meaning that going from zero to 15 minutes of exercise per day is more beneficial than going from 60 to 75 minutes. Moreover, the 2018 Physical Activity Guidelines for Americans edited its recommendation that physical activity occur in bouts of at least 10 minutes. Now, every single second of activity counts toward its weekly recommendation. That recommendation calls for at least 150 minutes a week of moderate-intensity aerobic activity (such as brisk walking), plus at least two days a week of total body strengthening activities. If activity is more intense, such as running or sprinting on a stationary bike, as little as 75 minutes may be enough. It's important to realize that these guidelines refer to the minimum amount necessary for good health, not to significantly improve fitness.

So how do you know how much your personal bare minimum is for improving fitness? That depends of several factors, including age, gender and genetics. For example, it takes less time and effort to make fitness gains when you're young, a time when your body has higher base levels of muscle, testosterone, growth hormone and bone mass. Fortunately for women, a 2011 study in the American Journal of Human Biology found that even though women have lower base levels of muscle mass, they are able to make similar percentage gains in muscle mass compared with men. In terms of genetics, it is true that some people can improve fitness faster and to a greater extent than others. Hopefully, you won that genetic lottery. It is also true that everyone has a genetic upper limit to their fitness potential. And the closer you are to that limit, the more challenging it is to continue making progress toward it.

In the first few months of a new training program, especially one focusing on strength development, you can expect to make big gains in strength quickly as your neuromuscular system learns how to execute the exercises more efficiently. It's also important to realize that during this time, despite increases in strength, muscle growth isn't as pronounced. After a couple of months though, further increases in strength are mainly due to muscle growth as the neuromuscular system adapts to your exercise routine.

Specifically, if you want to build muscle, as little as two 20 to 30 minute sessions may be enough to start to see some muscle definition. That means training each muscle group twice a week. If you want to maintain the muscle you already have, then once a week may be enough. To get the most out of each session, focus on large multi-joint movements such as squats, deadlifts, rows and push-ups rather than isolation exercises like biceps curls and leg extensions.

If your goal is to keep your heart healthy, lower blood pressure or cholesterol, then the federal guidelines' bare minimum may not be adequate. The American Heart Association recommends at least 40 minutes of moderate intensity aerobic activity three to four times a week. Before starting such a routine, it is important to check with your health care provider to make sure that it's safe to pursue this level of activity. The good news is that significant improvements in cardiovascular fitness can be expected relatively quickly, in the neighborhood of three to four weeks.

So as you contemplate your exercise routine during the holidays, keep in mind that what you do between Thanksgiving and Christmas is not as important as what you do between Christmas and Thanksgiving.

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What's the minimum amount of exercise I need to do to see results? - Richmond Register

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Watch a Dragon launch towards the International Space Station today! – Massive Science

December 8th, 2019 11:50 am

It's easy to give thoughtless gifts. This year, give thoughtful gifts: science gifts! They're experimentally validated as wonderful*. This is Massive's 2019 holiday science shopping guide, with cool stuff from all around the science web, for Thanksgiving, Black Friday, Christmas, and beyond.

Illustrated by Matteo Farinella, Designed by Allan Lasser

Massive Science

Oh wow, so weird to see us at the top here. The coolest thing on this list is definitely the Women of Science Tarot deck we made. The deck features is itself a work of art, with beautiful original work from Matteo Farinella. Instead of the traditional face cards of many tarot decks, instead there are portraits of important women in science's history, including Mae Jemison, Rachel Carson, Marie Curie, Ada Lovelace, and more. If the the $75 price tag is too steep, there are also postcard packs with art from the deck and posters!

Genius Games

The geniuses at Genius Games make science-themed board games and card games. In Virulence, take on the role of a virus and replicate. Build atoms in Subatomic. Or, become the world's first programmers in Lovelace & Babbage. Massive has partnered with Genius Games to offer a 20% off coupon, just use the code MassiveScience20!

Courtesy of Genius Games

Two Photon

The undisputed champion of science art, pins, jewelry, and more. Our favorites include the neuroscience section, with brain pins and neuron necklaces, the virus t-shirt, and the nameplate necklaces, with options like "Scientist", "Doctor", and "Programmer."

Stitching Hew

What really sets Stitching Hew apart are their intricate stitch patterns, especially the Brainbrow Pyramidal Neuron Print, detailed enough to make Cajal blush. There are even downloadable stitch patterns or an entire beginner's science hand embroidery kit.

Rachel Ignotofsky

The prolific author and illustrator made one of our favorite books, Women in Science: 50 Fearless Pioneers Who Changed the World. But she also has other books, like Women in Art: 50 Fearless Creatives Who Changed the World, along with a whole pile of beautiful art prints to choose from.

Science On A Postcard

If you're looking for an enamel pin to signal your allegiance to a particular scientific field, then this Etsy shop is for you! Packed with notebooks, postcards, stickers and an even a pocket mirror, the Science On A Postcard shop hosts some of our favourite pins, including ones that say science communicator, future scientist and that climate change is real.

Awkward Yeti

You've undoubtedly seen their comics all over the great wide web, but Awkward Yeti's store is packed with goodies. There's tabletop games for the gamer who loves organs, some of the best stuffed organs (okay, the only stuffed organs) we've seen, like a uterus and an irritable bowel, and prints from the comic.

Courtesy of Awkward Yeti

Waterlust

You don't have to be a marine scientist to love their products. Waterlust carries leggings (with pockets!), rashguards and swim tops, board shorts, and more for people who love being in the water. Their products are great on land too the fabric is soft and stretchy, and the leggings and shorts have a wide waistband that makes them incredibly comfortable for lounging around the house or going to the gym. Each pattern is dedicated to a specific marine conservation cause (my favorite is the Floridian Aquifer collection). Their products are partially made from recycled plastic bottles and the gear is shipped in eco-friendly packaging, making Waterlust a great choice for the outdoor enthusiasts in your life!

PurpleLilacAmigurumi

This science crochet shop is run by a PhD student at the University of Toronto, so you know the plushies are accurate. Oh and they're lovely too. Take the crocheted neuron necklace, or our personal favorite, the Islets of Langerhans crochet pattern.

Skype a Scientist

Skype a Scientist is one of the best science outreach organizations we know of and they have the merch to match. If you love snakes and also Greek myths, consider this Medusa-as-a-scientist t-shirt. Or rather, if you're more of an astrobiology person, maybe the hardy tardigrade is more your speed.

The Vexed Muddler

If you're interested in science-themed underwear, this is the store for you. Consider the Maratus volans (aka the peacock spider) boxer briefs, which to be honest are kind of terrifying. If that's not your thing they also have phylogenetic tree skirts, intergalactic space dresses, and oh what the heck here's black widow underwear.

Slow Dance

Perhaps something a bit more...meditative? Slow Dance is a frame that produces slow-motion, real-time movement. The creators say it helps lower stress and is quite good for meditation (we weren't just being cute).

*data not shown

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Watch a Dragon launch towards the International Space Station today! - Massive Science

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BelleCell: the ‘bio-hacking’ clinic aiming to shake up wellness – The Times

December 8th, 2019 11:50 am

BelleCell in London

Ive seen the future. And its unexpectedly sandwiched between those exuberant bastions of indulgence, the Ritz and Le Caprice. Rather like Harry Potters Platform 9 at Kings Cross, look carefully and theres a spiral staircase to a subterranean world. Once a cellar that housed Winston Churchills wine collection, it is now a series of neon-lit vaulted passages filled with white-coated therapists and space-age machines. This is the home of Londons first biohacking clinic.

BelleCell is the creation of Kasia Zajkowska, a Polish bioscientist and Cambridge graduate who specialised in genetics and molecular biotechnology and who looks as if she could be Bella Hadids sister. Ill have what shes having. Fifteen years ago science was focused on increasing the human life span, Zajkowska says. Now its

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SUO 2019: Response of FGFR3 Alterations In High-Grade Non-Muscle Invasive Bladder Cancer Treated with Intravesical BCG Therapy – UroToday

December 8th, 2019 11:48 am

Washington, DC (UroToday.com) On the final day of the Society of Urologic Oncology Meeting (SUO 2019), the six best abstracts submitted were selected for presentation. One of these highlighted studies from Memorial Sloan Kettering Cancer Center (MSKCC) evaluated the differential response of high grade non-muscle invasive bladder cancer to Bacillus Calmette-Guerin (BCG) on the basis of FGFR3 alterations. Dr. Timothy Clinton, a urologic oncology fellow at MSKCC, presented the groups findings.

Recently, the FDA approved Erdafitinib, a fibroblast growth factor receptor (FGFR)3 kinase inhibitor, for use in metastatic urothelial carcinoma on the basis of phase II results published this summer in NEJM. In that publication, Loriot et al. demonstrated a 59% response rate in patients with unresectable or metastatic urothelial carcinoma.1 These results have driven interest in expanding the use of FGFR3 kinase inhibitors and looking to FGFR3 alterations for prognostication. Specifically, FGFR3 mutations have been previously associated with lower response rates to immune checkpoint inhibition, are more commonly identified in non-muscle invasive bladder cancer which is specifically less likely to progress. For these reasons, Dr. Clinton postulated that FGFR3 alterations may be able to predict BCG response.

To that end, Dr. Clinton and colleagues identified treatment nave patients with high-grade nonmuscle invasive bladder cancer (NMIBC) enrolled in a prospective protocol that captured targeted exon sequencing on pretreatment tumor DNA and matched germline DNA. Within the MSKCC cohort there were over 1,400 bladder specimens with a quarter demonstrating genomic alterations in FGFR3. Of these patients, 119 patients with high-grade NMIBC underwent BCG treatment with 51containing aFGFR3alteration (43%); 39 patients (76%) were cTaHG and 12 (24%) were cT1HG at diagnosis. Interestingly, no patients with CIS had alterations in FGFR3.

Dr. Clinton proceeding by highlight the differential response to BCG between those who were FGFR3 wild-type and those with alterations. Overall, the median follow up was 60 months (IQR 32-75). At that time 39% of the entire cohort was free from high-grade recurrence with a significant difference between the two groups. 65% of wild-type patients were free from high-grade recurrence, were as only 39% of the FGFR3 alteration group was similarly recurrence-free(p<0.05). There was no difference in progression, however, the rate was very low in both groups. Looking more in depth into the FGFR3 altered tumors, the group looked for additional mutations that corresponded to BCG response, identifying significant co-occurrence ofFGFR3mutations with cell cycle genes includingCDKN2A(p=0.03) andMDM2(p=0.03) and noFGFR3mutated tumor contained anERBB2mutation.

Overall, Dr. Clinton concluded that while FGFR3 has been historically associated with favorable prognosis, FGFR3altered tumors are associated with high recurrence rates following BCG. Given these findings and the recent BCG shortages, patients with these alterations may benefit from alternative therapy with FGFR3 kinase inhibitors. The study represents a major step in predicting BCG response rates and FGFR3 profiling could represent a novel path for personalized medicine in the future. Clinical trials for FGFR3 in NMIBC are currently underway with results pending.

Presented by:TimothyClinton, MD, Urologic Oncology Fellow at Memorial Sloan Kettering Cancer Center

Written by: Adrien Bernstein, MD, Society of Urologic Oncology Fellow, Fox Chase Cancer Center, Fox Chase Cancer Center, Philadelphia, PAat the 20th Annual Meeting of the Society of Urologic Oncology (SUO), December 4 - 6, 2019, Washington, DC

References:1.Loriot, Y., Necchi, A., Park, S., Garcia-Donas, J., Huddart, R., & Burgess, E. et al. (2019). Erdafitinib in Locally Advanced or Metastatic Urothelial Carcinoma.New England Journal Of Medicine,381(4), 338-348. doi: 10.1056/nejmoa1817323

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SUO 2019: Response of FGFR3 Alterations In High-Grade Non-Muscle Invasive Bladder Cancer Treated with Intravesical BCG Therapy - UroToday

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One Stop Systems does AI on the Fly at SC19 – insideHPC

December 8th, 2019 11:48 am

In this video from SC19, Jaan Mannik from One Stop Systems describes how the company delivers AI on the Fly.

AI on the Fly puts computing and storage resources for the entire AI workflow, not in the datacenter, but on the edge near the sources of data. Applications are emerging for this new AI paradigm in diverse areas including autonomous vehicles, predictive personalized medicine, battlefield command and control, and industrial automation. The common elements of these solutions are high data rate acquisition, high speed low latency storage and efficient high performance AI training and inference computing. All of these building block elements are connected seamlessly with memory mapped PCI Express system, interconnected and customized as appropriate, to meet the specific environmental requirements of in the field installations.

AI on the Fly solutions are different than traditional datacenter centric AI infrastructure, as they must deploy in harsh and rugged environments. The solutions must meet unique criteria for shock and vibration, redundancy, large operating temperature, altitude ranges and uninterrupted power sources. Few companies have the expertise across all the technologies required for designing and delivering tightly integrated AI on the Fly platforms.

OSS is a custom manufacturer of specialized high performance computing systems for industries that are showing the largest proliferation of use cases for AI on the Fly systems. These industries include:

These edge applications have unique requirements over traditional embedded computing. There is no compromise possible in delivering high performance while maintaining efficient space, weight and power. Delivering the high performance required in edge applications necessitates PCIe interconnectivity providing the fast data highway between high speed processors, NVMe storage and compute accelerators using GPUs or application specific FPGAs. AI on the Fly high performance applications will naturally demand this capability on the edge. Additionally, these solutions often require unique space and power saving form factors and specialized rugged enclosures.

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8 things that can compromise your immune system during the festive season – IOL

December 8th, 2019 11:47 am

Health & Wellness/5 December 2019, 09:00am/IOL Supplied

The countdown to the end-of-year summer break has begun, but its also the season when many South Africans fall prey to tummy bugs, unexpected colds, migraines and other nasties which can spoil the holiday fun.

Alisha Mackintosh, Allergy and Immunity Portfolio Manager at Pharma Dynamics says its likely that certain changes in our routine may be to blame.

During the holidays we travel more, eat out-, shop- and party more. We stay up late and are perhaps a little more relaxed about hygiene, which can weaken our immune system and make us more susceptible to viruses and bacteria.

Macintosh says we should be wary of:

Eating too much sugar

Its the time of year when many give in to festive season temptations that are often laden with sugar without realising that this weakens white blood cells. If youre consuming sweet things throughout the day it means that your immune system may continuously be operating at a distinct disadvantage.

Drinking too much alcohol

The holidays are synonymous with parties and alcohol, but too much booze can inhibit the bodys ability to fight infection, so rather drink in moderation.

Staying up late

Partying or catching up on Netflix till the wee hours of the night and getting up later in the mornings can trigger migraines. Sticking to healthy sleep habits and getting eight hours of sleep can reduce the frequency of headaches by 29% and the intensity by 40%.

Holiday shopping

When on holiday, we tend to shop more, which means were handling and drawing cash more than usual. Money carry about 3 000 different types of bacteria that can lead to all sorts of illnesses. Always wipe shopping trolleys and surfaces with sanitising wipes before touching it or wash your hands afterwards.

Traveling by plane

Some studies have found that flying heightens our risk of catching a cold by 80%. Sitting in close quarters for a long flight might be partially to blame, but we typically push ourselves to meet all the last-minute deadlines before going on holiday, which puts a strain on our immune system. Consider boosting your immunity before a plane flight by getting enough rest, eating healthily and managing stress.

Taking an immune-boosting supplement is also recommended. Look out for supplements that contain vitamin C, zinc and Echinacea, such as Efferflu C to keep the common cold at bay.

Dirty air conditioners

As the mercury rises during the holidays, the more well be making use of air conditioning units in the car and house to cool down, but if it hasnt been cleaned regularly, it could be harbouring harmful bacteria that can affect those with compromised immune systems. Its recommended that air conditioning systems get debugged at least every two years.

Too many holiday demands

Securing the house before going away on holiday, hosting and accommodating family, getting all the shopping done etc could all increase your stress load, which doesnt do your immune system any good. Be aware of these stressors and take steps to better manage the demands that are placed on you to make the holiday season less challenging.

Crowds

Holidays mean more crowds no matter where you go and airborne germs thrive in crowded environments, which heightens ones risk of getting sick. When finding yourself in a high-risk environment, try Nexa Travelshied a natural nasal spray which coats the nasal membrane, trapping viruses and other airborne allergens to keep you healthy.

Other common illnesses that holidaymakers often pick up include fever, diarrhoea, respiratory infections, giardiasis (infection of the small intestine), skin or soft tissue infections. Proper hygiene practices are of paramount importance and never consume food or water from places where the risk of contamination is high.

Apart from plasters and Burnshield, your holiday first-aid kit should always include sunscreen, mosquito repellent, antibacterial cream, antihistamines, eye drops, pain medication and medicine to help with stomach cramps and nausea as these ailments are likely to surface during the holidays, she advises.

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8 things that can compromise your immune system during the festive season - IOL

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Treating Cancer 5 Types of Immunotherapy – Technology Networks

December 8th, 2019 11:47 am

ListDec 03, 2019| by Laura Elizabeth Lansdowne, Senior Science Writer for Technology Networks

Numerous treatments are available to patients with cancer.Several factorsincluding; the type and stage of a patients cancer, their general health, and preferences impact treatment options.Some available treatments harness theimmune system the bodys natural line of defense against infection and disease to fight cancer.

This list explores the different types of immunotherapy, how each type works, and takes a closer look at some examples of approved immunotherapies.

Types of adoptive cell therapyTumor-infiltrating Lymphocyte (TIL) Therapy (Unmodified Cells)Naturally occurring T cells that have already infiltrated a patients tumorare harvested from resected tumor material, activated and then expandedex vivo. The activated T cells are then re-infused into the patient. There is now a greater number of activated cells available, enhancing the bodys anti-tumor immune response.Engineered T-cell Receptor (TCR) Therapy (Modified Cells)In some cases, a patients T cells either cannot recognize a tumororare unable to activate and expand sufficiently, meaning they are incapable of mounting a response against the cancer cells. Engineered TCR therapy can be used to combat this problem. This approachinvolves taking T cells from a cancer patient, modifying themso that they are armed with a new T cell receptor that allows them to target specific tumor antigens. Bothsurfaceandintracellular proteins can be displayedas antigens attached to the major histocompatibility complex (MHC) on the surface of a cancer cell.

Whilst T cells have the ability to recognize many different antigens, distinct types of T cell can be genetically engineered to recognizespecificantigen targets meaning treatment can be personalized to individual patients.Chimeric Antigen Receptor (CAR) T-cell Therapy (Modified Cells)In this approach a patients T cells are genetically engineered to display asyntheticreceptor called a chimeric antigen receptor or CAR. CARsdisplay antigen-binding fragmentsof a specific antibody fused to an intracellular T-cell signaling domain. The CAR T cells are expanded and infused back in to the patient. CAR T cells are able torecognize a smaller range of potential antigen targetscompared to TCRs.Natural Killer (NK) Cell Therapy (Modified and Unmodified Cells)Severalnatural killer cell-based immunotherapeutic strategiesare currently being investigated. Whilst autologous NK cells expandedex vivohave been tested in a range of clinical trials for various cancers, success has been limited. This is thoughtto be due to inhibitory receptors on autologous NK cells matching self MHC class Ipresented on tumor cells, and this self recognition consequently inhibited NK cell activation.

Genetic modification of NK cells is also being investigated CAR-NK therapy is currently being clinically evaluated, for example. It is thought treatment with CAR-NK cells could offer severaladvantagesover CAR-T cells:

AdjuvantsThe term adjuvant originates from the Latin word adjuvare meaning help. Adjuvants work by activatinginnate immune pathwayswhich in turn stimulate general immune responses and promote adaptive responses. Adjuvantscan inducedamage-associated molecular patterns (DAMPs) and/or pathogen-associated molecular patterns (PAMPs) that can activate various pattern recognition receptors (PRRs) on innate immune cells.

An antibody is a protective protein produced by B cells in response to a specific antigen. Scientists can harness the power of antibodies to supplement a patients own immune system by synthesizing customized antibodies. These antibodies specifically target antigens that are typically found in greater numbers on the surface of

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Genetically engineered animals offer fresh hope to heart valve patients – Horizon magazine

December 8th, 2019 11:47 am

Every year, about 300,000 people worldwide receive a new heart valve. Whenever possible, doctors use valves made of tissue from cows or pigs, because the synthetic alternatives can cause blood clots.

But there is a hitch. Although animal tissue valves can last up to 30 years in people over 60 years old, they can be destroyed in just five years in a younger person, probably because of their more aggressive immune system.

Enter the genetically engineered bull.

Scientists used CRISPR gene editing technology to create two bovine mutations that should lessen peoples immune responses to the animal tissue.

The mutations knock out two sugars which coat the bulls cells but are not found in humans: -Gal and Neu5Gc.

The objective is to have animals that express tissues that are less foreign to the human body, said Dr Emanuele Cozzi, coordinator of a project called TRANSLINK, which has been trying to improve the long-term success of heart valve replacements.

In theory this means peoples immune systems will be less likely to attack the animal tissue, added Dr Cozzi, who is director of the Transplant Immunology Unit at Padua University Hospital in Italy.

Clone

As part the project, an Italian company, Avantea, created bovine cells with the two mutations and used them to clone a bull with a technique similar to the one that produced Dolly the sheep.

We are the first to make cattle (with these) mutations, said Professor Cesare Galli, co-founder of Avantea.

The cloning step is required to make the founder animals. Then they can breed normally, said Prof. Galli.

Avantea had created the same mutations in pig cells using a technology called Transcription activator-like effector nucleases (TALEN) to edit the DNA, before CRISPR was available.

With CRISPR it is much easier to prepare the reagents that are needed to implement the system, said Prof. Galli.

That makes CRISPR cheaper because the reagents can be prepared in-house. However, in theory at least, it is less accurate, he added. Being less precise in recognising the sequence to cut, there is the risk of undesired cuts - this is a risk that has yet to be quantified.

'The animals we generated could have a potential application for food consumption, at least for people who do not tolerate red meat.'

Professor Cesare Galli, co-founder, Avantea, Italy

Quality of life

About 100,000 people a year are given synthetic heart valves because they are too young to receive the animal tissue version.

But these valves can lead to dangerous blood clots forming, so patients have to live on anticoagulants that impose severe limitations on a young persons life, saysDr Cozzi.

People have to avoid competitive sports and jobs with a high risk of injury, like construction or some police work.

If an accident occurs while on duty (they) may bleed to death, said Dr Cozzi.

Although preliminary data suggests that peoples immune systems attack valve transplants in response to the animal tissue used, scientists need more solid evidence of this before they can recommend using the genetically engineered animal tissue, says Dr Cozzi.

Other factors including someones blood pressure cannot yet be ruled out as affecting the valves lifespan, he says.

To understand more, TRANSLINK is carrying out a study of 1,600 cardiac patients the largest of its kind to compare their immune responses to animal or synthetic valve transplants or other types of surgery. The results are expected next year.

If the study shows convincingly that immunology is behind the premature failure of animal-derived heart valves, it should not be too difficult to find potential investors who could bring the genetically engineered tissue valves to market, says Dr Cozzi.

My hope would be that, based on the data of our study, we may change the outlook of young patients (and offer them) a better quality of life.

The mutations in both pigs and cows may pave the way for people to receive transplants of whole animal organs, Dr Cozzi says.

Red meat allergies

The cloned animals may also benefit people allergic to red meat a reaction which sometimes develops after they have been bitten by a tick.

Scientists think the main culprit is the -Gal sugar found in all animals other than primates.

Anything from a steak to collagen used in cosmetics can trigger a reaction, which can range from a skin rash to anaphylactic shock.

The animals we generated could have a potential application for food consumption, at least for people who do not tolerate red meat, said Prof. Galli.

Some scientists in the US are also looking at possible links between the Neu5Gc sugar and cancer. The World Health Organization has classified red meat as probably carcinogenic to humans,although there is limited evidence.

Millions of years ago, humans developed a mutation that stopped the production of Neu5Gc and produced a slightly different sugar called Neu5Ac instead. The mutation made people resistant to malaria, and quickly spread across the population.

Pigs, sheep, cows and most other mammals with the exception of deer and some dogs - produce the Gc form which is highly antigenic in humans, says Prof. Galli, meaning it prompts a strong immune response.

Chicken and fish do not, which is one reason they are considered to be healthier to eat.

The cloned cows could be a useful source of milk for baby food, as it would be closer to human milk because it does not carry the antigen, says Prof. Galli.

Avantea also plans to use CRISPR to create horses with the same mutations as the cows and pigs. Horse serum is used to make antidotes to snake bites, but it can trigger adverse reactions in some people. Knocking out -Gal and Neu5Gc may prevent that, he says.

The potential for the cloned pigs, cows and horses to improve peoples health is huge. But for the time being, much of it is still theory, the scientists say.

We have the tools now, but there is work to be done to prove whether there is an advantage or not, said Prof. Galli.

The research in this article was funded by the EU. If you liked this article, please consider sharing it on social media.

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‘Crazymothers’ Want You to Stop Calling Them ‘Anti-Vaxxers’ – Livescience.com

December 8th, 2019 11:47 am

A group of people opposed to vaccinations has requested that media stop referring to them as "anti-vax." Instead, they would prefer to be called "vaccine risk aware."

On Dec. 1, an anti-vaccine group called the Crazymothers raised its plea on Twitter and Instagram, asserting that the term anti-vaxxer is "derogatory, inflammatory, and marginalizes both women and their experiences." In response, many social media users chimed in with their own alternative labels for the group, including "plague enthusiasts," "polio fanciers," "pro-disease" and "patient zero."

In response to this feedback and subsequent media coverage, the Crazymothers posted a screenshot of a HuffPost article along with the hashtag "#IHitANerve."

The Crazymothers' founder, Hillary Simpson, frequently captions posts with the hashtag #DoYourResearch; so, in that spirit, here are the basics about vaccine safety.

Long story short, the main risks to be aware of are those associated with not vaccinating. Decades of research shows that vaccines are safe and effective and that serious side effects are rare.

When invaders such as bacteria or viruses enter the body for the first time, the immune system generates an elite team of proteins called antibodies to help fight off the invasion. Antibodies latch onto unique proteins that hang off the invaders, known as antigens, and either destroy the pathogen themselves or call in other immune cells to help. The immune system remembers how to build these antibodies long after the initial infection clears, enabling the body to fend off those same type of bugs should they ever launch another attack.

Unfortunately, when a completely unfamiliar antigen enters the body, the immune system may take several days to build up its antibody army. Particularly nasty bugs, like the measles virus, can overwhelm the immune system while its defenses are down.

That's why we have vaccines.

Vaccines contain dead or weakened pathogens that cannot cause infection but do kick the immune system into gear. Once the vaccine enters the body, the immune system produces antibodies as if it's fighting an actual infection. If a vaccinated person later encounters the antigen attached to a real microbe, their body already knows how to quickly ramp up its production of the antibodies needed to fight the infection

Over the past two decades, childhood vaccines have saved the lives of 732,000 U.S. children and prevented more than 300 million kids from getting sick, according to a 2014 study from the Centers for Disease Control and Prevention (CDC).

A recent statement from the American Academy of Pediatrics (AAP) put it best: "Vaccines are safe. Vaccines are effective. Vaccines save lives."

Like all medicinal products, vaccines carry some risk of side effects, but nearly 90% of these are not serious, according to the CDC. A 2011 report from the National Academy of Medicine backs this claim, noting that in more than 1,000 studies of vaccines, only rarely did patients experience severe reactions, such as seizures, inflammation of the brain, and fainting..

More than 20 scientific studies confirm that no link exists between the MMR vaccine (for measles, mumps and rubella) and the development of autism, according to the CDC. The study that originally suggested such an association has been retracted and repeatedly discredited.

The MMR vaccine has legitimately been linked to fevers, and in extreme cases, fever-triggered seizures. About 1 in every 3,000 to 4,000 children experiences these seizures after being vaccinated, according to the 2011 report from the National Academy of Medicine.

The rotavirus vaccine has been linked to a serious intestinal disorder called intussusception, but in a 2014 study, scientists found that only 1 in 65,000 vaccinated children develops the condition. Other vaccines may cause mild reactions, like the vague, "flu-like symptoms" you get after getting a flu shot, but these side effects hardly compare to catching the infection itself.

Because vaccines work.

Following the advent of the chickenpox vaccine, cases of the disease fell about 80% over the following decade, according to a 2012 study. Before that vaccine existed, about 4 million people caught chickenpox in the U.S. every year, and among those, 11,000 had to be hospitalized and 100 died, according to the Immunization Action Coalition.

After the human papillomavirus (HPV) vaccine was introduced, the rate of HPV infection among teen girls fell by 56% over the next four years, according to a 2013 study. The rotavirus vaccine has prevented 65,000 U.S. children from being hospitalized with the disease since 2006, according to a 2011 study.

What's more, vaccinating against one disease could bolster your immune system against others. A 2019 study found that catching the actual measles virus wipes the immune system's "memory" of other antigens it has already encountered. In fact, before the measles vaccine was introduced, in the 1960s, an estimated 50% of childhood deaths were associated with infections that kids caught after surviving a bout of measles, according to a 2015 study published in the journal Science. The vaccine, in contrast, defends against the measles virus without damaging the body's defenses against other infection.

Unfortunately, due to a dip in vaccinations, the number of measles cases has increased by more than 280% since 2018, according to the World Health Organization. That means hundreds of thousands of people who caught the virus this year may now bear the brunt of secondary infections as well.

Founded in 2018, the Crazymothers have just over 1,000 followers on Twitter and about 18,000 on Instagram. The group recently hosted an event in Washington to "raise awareness to the current epidemic of chronic health conditions, injuries and death from vaccination." Nearly 3,000 people attended, according to a Crazymothers Instagram post.

The group sells merchandise and offers "expert" advice on its website. The T-shirts depict anti-vaccine moms as superheroes, and these "experts" raise concerns about specific ingredients found in vaccines and the methods by which vaccines are produced.

The efforts of groups like this are a problem, because getting vaccinated doesn't just help the person stuck with the needle; it also protects infants and many people with weak immune systems who cannot be vaccinated at all. Vaccines ensure that fewer cases of the disease occur, and therefore, those without the means to defend themselves are more likely to stay safe and healthy. Anti-vaccine groups like the Crazymothers aim to make vaccination optional, which would place these vulnerable populations at risk, according to the APP.

The Crazymothers may prefer the term "vaccine risk aware," but in reality, unvaccinated children face far greater health risks than those who do get vaccinated. Meanwhile, the vulnerability to disease of unvaccinated kids places others at risk. The fewer people who get vaccinated, the more people will contract perfectly preventable diseases.

To learn more about vaccines, check out the Live Science page dedicated to the topic.

Editor's note: A previous version of this story incorrectly noted that 4,000 people in the U.S. used to catch the chickenpox each year, when the true number was 4 million. The statistic was updated on Dec. 6.

Originally published on Live Science.

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MaaT Pharma Announces the Presentation of Positive Data with Its Lead Microbiome Biotherapeutic in Intestinal-Predominant Acute…

December 8th, 2019 11:47 am

LYON, France--(BUSINESS WIRE)--MaaT Pharma announced today that leading hemato-oncological experts presented clinical data on the compassionate use of MaaT Pharmas lead full-ecosystem microbiome restoration biotherapeutic, MaaT013. The data included eight patients that developed gastrointestinal-predominant, acute Graft-versus-Host-Disease (GI aGvHD) after receiving an allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) to treat their hematologic malignancies. All patients were positively impacted by the MaaT013 treatment, with three patients achieving complete response. GvHD, a condition where the transplant donors immune cells attack the patients tissues, is one of the most serious complications of allo-HSCT, and its acute GI form is fatal in most cases. MaaT013 features a consistently high diversity and richness of microbial species in their natural environment. It aims to restore the symbiotic relationship between microbes in the gut and the immune system of the patient to correct the responsiveness and tolerance (homeostasis) of immune functions and thereby contain GI GvHD. The results were presented in a poster presentation on December 7, 2019 during the 61st American Society of Hematology (ASH) Annual Meeting and Exposition held in Orlando, Florida.

The GI aGvHD patients who were treated with MaaT013 had a very poor prognosis with no other therapeutic options. The results following MaaT013 administration showed a positive impact on all patients, commented Professor Mohamad Mohty, MD, PhD, Head of the Hematology and Cellular Therapy Department at Sorbonne University, Saint Antoine Hospital in Paris. The most impressive results were seen in those patients who achieved a complete response and who were able to taper and stop using steroids and other immunosuppressants without relapse of gastrointestinal symptoms.

In the presented evaluation, eight patients with a median age of 67 were treated for classical aGvHD, late-onset aGvHD or aGvHD with overlap syndrome that were either steroid-resistant or steroid-dependent following stem cell transplantation. These patients had previously been treated with and failed up to five lines of systemic therapy for aGvHD. Each patient received at least one and up to three doses of MaaT013 and treatment response was evaluated seven days after each administration and on day 28 after the first dose. Based on the best response to the treatment, all eight patients experienced at least a partial response with three patients achieving complete response, two patients with very good partial response and three patients with partial response. Overall, the data demonstrated that reintroduction of a full-ecosystem microbiota provided therapeutic effect and was tolerated in a satisfactory manner in these patients.

Herv Affagard, Co-founder and CEO of MaaT Pharma added, We provided our cGMP-manufactured lead biologic drug, MaaT013, to hospitals as part of a compassionate use program to give GI GvHD patients a therapeutic option where there are no other available treatments after steroids and additional lines of treatment. These findings indicate that reestablishing the gut microbiome improved outcomes in these patients.

Moreover, MaaT Pharma is currently conducting the HERACLES Phase II clinical trial (NCT03359980) to evaluate the safety and efficacy of MaaT013 in steroid-refractory, GI aGvHD patients, with more than half of the patients enrolled.

To date, a total of 46 patients with GI GvHD have been treated with MaaT013, including patients under compassionate use and patients enrolled in the Phase II clinical trial. MaaT Pharma is actively developing an oral formulation of MaaT013 (a capsule, MaaT033) to provide easier administration for patients while delivering a similar effect of regenerating the microbial ecosystem with the goal of restoring immune homeostasis in the gut.

The poster can be viewed on the companys website under News.

About HERACLES

The HERACLES study is a multi-center, single-arm, open-label study, enrolling 32 patients to evaluate the efficacy and safety of MaaT Pharmas lead microbiome restoration drug candidate, MaaT013, in steroid-resistant, gastrointestinal-predominant aGvHD patients. Acute GvHD is a serious, often fatal syndrome typically involving the gut, skin, and liver. Treatments up to now focused largely on suppressing the immune reaction that is induced by the donor cells derived from the hematopoietic stem cell graft reacting against the host. These strategies have remained clinically unsuccessful in most cases, with mortality rates around 80% after twelve months in steroid-resistant cases. Patients with hematological malignancies receive multiple courses of chemotherapy, antibiotics, and ultimately conditioning before HSCT, which are known to severely impact the gut microbial composition.

About MaaT013

MaaT013 is the first full-ecosystem, off-the-shelf, reproducible, enema formulation manufactured using MaaT Pharmas integrated Microbiome Restoration Biotherapeutic (MMRB) platform. The product has a stability of up to 24 months and is characterized by a high diversity and consistent richness of microbial species derived from pooled healthy donors and manufactured at the companys centralized European cGMP production facility. MaaT013 has been granted Orphan Drug Designation by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) and is already being administered in compassionate use.

About MaaT Pharma

MaaT Pharma, a clinical stage company, has established the most complete approach to restoring patient-microbiome symbiosis to improve survival outcomes in life-threatening diseases. Committed to treating blood cancers and Graft-versus-Host-Disease, a serious complication of allogeneic stem cell transplantation, MaaT Pharma has already achieved proof of concept in acute myeloid leukemia patients. Supporting the further expansion of our pipeline into improving outcomes of immunotherapy in solid tumors, we have built a powerful discovery and analysis platform, GutPrint, to evaluate drug candidates, determine novel disease targets and identify biomarkers for microbiome-related conditions. Our biotherapeutics are produced under the strictest cGMP manufacturing and quality control process to safely deliver the full diversity and functionality of the microbiome. MaaT Pharma benefits from the commitment of world-leading scientists and established relationships with regulators to spearhead microbiome treatment integration into clinical practice.

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5 herbs you should take in the winter, according to a herbalist – Evening Standard

December 8th, 2019 11:47 am

The latest lifestyle, fashion and travel trends

Herbal medicine has had somewhat of a revival in the last few years, perhaps thanks in part to the likes of Gwyneth Paltrowand her love of adaptogens.

If, like us,you're attempting (failing) to stave off the office cold, and are interested in herbal alternatives to boost immunity, we askedherbalist and naturopath Jenya di Pierro, founder ofNotting Hill-based wellness spa Cloud Twelve, for the medicinal herbs she recommends her clients take during the winter months.

The best way to take herbs is in food sources rather than supplements, she explains,"Herbs should be part of our daily diet providing us with vital nutrients and protection against various ailments," says diPierro, who is also a member ofThe Association of Master Herbalists.

"However, the range of medicinal herbs extends beyond culinary varieties and if someone is already sick and requires stronger concentrations the best way to take them is in a tincture form, which is a method of extracting phytochemicals from a herb by macerating them in alcohol for a period of time."

Can chromotherapy help you banish the winter blues?

While some of these are easily availablesuch as garlic and ginger, di Pierro recommends purchasing some of the more obscure varieties from reputable herbalists, her pick isherbs-hands-healing.co.uk,so that you can besure they're harvested, preserved and transported ethically and effectively.

Here are her five top medicinal herbs to take while it's cold out.

Siberian ginseng is an adaptogen (Shutterstock / JRJfin)

Siberian ginseng belongs to the class of herbs that are called adaptogens. Adaptogens aremarkable herbs that help the body adapt to stress and increase vitality. We often get sick when we are tired, cold and flu is the way our body tells us that it needs rest. Adaptogens are very helpful in providing us with nourishmentand, as a result, resistance to disease. They are amphoteric, i.e. have a normalising effect on the body, calms us down when we are wired and can boost our energy when we are tired.

Siberian ginseng specifically enhances immunity against infections, protects against environmental pollutants and radiation by enhancing the liver's abilityto break down toxins. It also has a powerful anti-fatigue effect, can increaseendurance and the ability of the mitochondria cells to produce energy.

Take ginger for a circulation boost (Photo by Dominik Martin on Unsplash)

Ginger is a wonderful warming herb and a circulatory stimulant. Another reason we get sick in winter is because everything gets sluggish when its cold and poor circulation and nutrient supply to tissues and organs results in various deficiencies.

Ginger stimulates, heart and circulation and has a warming effect on the body. It also has anti-bacterial and anti-viral properties and is excellent for sore throats, bringing down fever, clearing catarrh and a wide range of bacterial and viral infections.

The benefits of crushed garlic are greatly reduced by cooking (Photo by team voyas on Unsplash)

Garlic has similar properties and is possiblythe strongest natural anti-bacterial, anti-fungal and anti-viral herb that exists. Its active component allicin is released when garlic is crushed, sadly its beneficial properties are greatly reduced by cooking. One of the best garlic preparations is garlic macerated in apple cider vinegar. Its one of the most popular herbal products at Cloud Twelve in winter and it doesnt give you smelly breath.

Another effective preparation especially for babies are garlic socks. Garlic penetrates very easily through the sock and skin and gets directly into the blood stream clearing infection quite quickly. It can also be applied on the chest through a cloth for respiratory tract infections and catarrh (applying it directly will burn the skin).

Echinacea is thought to activate the immune system (Photo by Meg G on Unsplash)

Echinacea is a wonder herb that does not directly kill bacteria or viruses, but activates our immune system and enhances lymph function which houses white blood cells, more specifically macrophages which play a key role in the orchestration of the immune response.

It is commonly used asa supportive therapy in the treatment of the common cold and upper respiratory tract infections and hasalso been shown to possess palliative effects on wound damage and inflammation.

The elder tree is considered a 'medicine chest'(Shutterstock / Africa Studio)

With its abundant white flowers,the elder tree has been called the "medicine chest", as it has so many health benefits.

A hot tea infusion of flowers can help duringthe onset of a cold, fever, flu, tonsillitis or laryngitis. Its decongestant and relaxant effects can also relieve catarrh and bronchial congestion. Both flowers and berries are antimicrobial.

Gargle with an elder flower infusion to soothe asore throat, mouth ulcers or inflamed gums, or use it as an eyewash for conjunctivitis or sore and tired eyes.

Flowers, meanwhile, can be calming and soothing for tension, anxiety and depression.

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Can the Keto Diet Help Fight the Flu? – Everyday Health

December 8th, 2019 11:47 am

New research suggests that the popular keto diet may help ward off influenza infection.

The study from Yale University, published November 15 in the journal Science Immunology, discovered that mice fed a ketogenic diet (low in carbohydrates but high in fat with moderate protein) were better able to fight off the flu compared with mice given foods that were high in carbs.

This study shows that the way the body burns fat to produce ketone bodies from the food we eat can fuel the immune system to fight flu infection, said the co-senior author Vishwa Deep Dixit, PhD, a doctor of veterinary medicine and a professor of comparative medicine and immunology at Yale, in New Haven, Connecticut, in a statement.

A ketogenic eating plan helps people shed pounds by drastically limiting the intake of carbohydrates (such as breads, pastas, and sweets), while increasing the consumption of meats, dairy, fats, and nonstarchy vegetables.

The diet puts the body into a metabolic state called ketosis, in which the liver breaks down fat into an energy source called ketones, which fuel the body in the absence of glucose.

This type of eating plan has been shown to help maintain blood sugar levels in people with type 2 diabetes. There is also some evidence, such as a study in Federal Practitioner from February 2017, that a keto diet may improve tumor response in cancer patients.

Another study, out of the University of California in Davis in 2017, found that mice on a high-fat diet had a 13 percent longer life span compared with mice on a high-carb diet.

In the latest study, Dr. Dixit and his collaborators observed that the ketogenic diet blocked the formation of inflammasomes, which are immune system activators that can cause harmful immune system responses.

Seeing this response, the scientists set out to test how the diet might affect the flu virus.

The researchers fed a group of mice infected with influenza a keto diet containing less than 1 percent carbs. Another group of infected mice received a standard diet with 58 percent carbs.

The ketogenic diet spurred the release of gamma delta T cells, immune system cells that produce mucus in the cell linings of the lung; but the high-carbohydrate diet did not. An increase in mucus helps capture and eliminate the flu virus from the system, according to researchers.

The researchers also found that the keto diet provided no protection against the influenza virus in mice specially bred without these gamma delta T cells. This confirmed that these cells play a critical role in warding off flu.

We have no idea yet why the gamma delta T cells appear to become activated by the keto diet. This is something well be pursuing in the future, says Emily Goldberg, PhD, a postdoctoral associate at the Yale School of Medicine who collaborated on the research.

A high-carb diet tends to stimulate inflammatory markers which inhibit immune function, says Jan Rystrom, RD, a certified diabetes educator at the Swedish Medical Center in Seattle, who was not involved in the Yale study. This could be the mechanism that the low-carb diet addresses.

On the other hand, some dietitians and medical experts believe that a low-carb diet can compromise the immune system. A lack of carbs may lead to a lack of energy and weaken a persons health overall. There is also evidence that a keto diet can be harmful to the gut microbiome, which is essential to overall well-being.

Rystrom points out that keto diets can have a lot of variation, and ones that are more plant-forward are likely to promote a healthier gut microbiota.

Generally speaking, it is true that the immune system should require increased glucose utilization to mount an effective immune response against infection, says Dr. Goldberg. Its important to keep in mind that there is still glucose availability, albeit very limited, even during a keto diet.

Although Rystrom suggests that the Yale study supports the anti-inflammatory effect of nutritional ketosis, she adds that a keto diet certainly would not be a first line treatment [for flu].

William Schaffner, MD, an infectious-disease specialist at Vanderbilt University in Nashville, Tennessee, has not seen significant data connecting diet with flu protection.

Its a very intriguing study, says Dr. Schaffner. If we can learn more about how the body fights flu, we can get smarter about how to treat influenza and perhaps prevent it.

He notes that there is some evidence that obesity may lead to a weaker response to flu vaccine, so that may be an indication of how diet could affect flu protection.

Research is needed in humans, however, to validate that the keto diet can effectively protect against the flu.

People are not the same as mice. Thirty thousand to 40,000 people die in the United States each year from influenza, says Len Horovitz, MD, a pulmonary specialist at Lenox Hill Hospital in New York City. Theres no substitute for protection better than a flu shot!

Link:
Can the Keto Diet Help Fight the Flu? - Everyday Health

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Celgene Gave This Tech Back to Editas Medicine, but It Could Prove Valuable – The Motley Fool

December 8th, 2019 11:47 am

In the middle of November, Editas Medicine (NASDAQ:EDIT) and Celgene (NASDAQ:CELG) announced changes to a development pact originally formed in 2015 with Juno Therapeutics, which is now part of Celgene. The agreement was amended in 2018, too, so the fact that changes were made wasn't necessarily big news. Editas received a $70 million upfront payment for executing the amended agreement, which was interpreted as the main takeaway from the announcement.

The announcement barely registered with investors and few gave it much thought for too long, especially after promising early results from the first clinical trials using a CRISPR-based medicine were announced by CRISPR Therapeutics days later.

But revisiting the amended collaboration agreement, and specifically what changes were made, hints at the long-term development plans of Editas Medicine. In short, it now has full control over an important class of immune cells. Whether that means the gene-editing pioneer lands another major development partner or goes full-steam ahead alone, investors can't overlook the significance.

Image source: Getty Images.

The basic scientific goal of the collaboration hasn't changed. Editas Medicine will use its gene-editing technology platform to engineer T cell receptors (TCR), while Juno Therapeutics will leverage its immunotherapy leadership to develop the engineered cellular medicines in clinical trials.

Why engineer TCRs? Immune cells rely on their receptors to identify targets, such as pathogenic bacteria and cancer cells. But immune cell receptors can be confused by molecules secreted within the tumor microenvironment, forcing them to halt their attack. They can also incorrectly attack an individual's own cells to trigger an autoimmune disease. A more recent concern stems from cellular medicines derived from a donor. Since the donor cells present different receptors compared to what the recipient's native T cells carry, the recipient's immune system (correctly) identifies the immunotherapy as a foreign substance, attacks it, and renders it less effective and less safe.

Therefore, it makes sense to engineer TCRs to create more potent and stealthier immunotherapies that are less likely to be tricked. Editas Medicine and Celgene still intend to do just that, albeit with subtle, yet important, differences to their development agreement.

Consideration

Previous Agreement (2015, 2018)

Amended Agreement (2019)

Focus

Cancer

Cancer and autoimmune diseases

Types of cells

CAR-T cells, alpha-beta T cells, gamma-delta T cells

Alpha-beta T cells

Juno Therapeutics exclusivity

Editas Medicine prohibited from all other work with CAR-T and TCRs in oncology

Editas Medicine prohibited from all other work on alpha-beta T cells and T cells derived from pluripotent stem cells

Upfront payment

$57.7 million (includes milestones collected under agreement)

$70 million

Milestone potential

$920 million plus tiered royalties

$195 million plus tiered royalties

Data source: SEC filings.

Essentially, Editas Medicine and Celgene have scaled back their original agreement in cancer and expanded their work to include autoimmune diseases. The most important detail is that the amended agreement allows the gene-editing pioneer to pursue the development of gamma-delta T cells, which were previously under the exclusive control of Juno Therapeutics. What does that mean?

Image source: Getty Images.

Without getting too far into the weeds, there are two main types of TCRs: alpha-beta and gamma-delta. The name refers to the molecular structure of the receptor, but that's not the important part.

Gamma-delta T cells, which comprise only about 5% of the T cells in your body, are thought to be one of the missing links in our understanding of the immune system. They're a mysterious bunch, but there could be significant value residing in the knowledge gaps.

These unique immune cells are governed by their own unique set of rules (relative to their alpha-beta peers) and straddle the innate immune system (what we're programmed with at birth) and adaptive immune systems (what's programmed as we encounter new environments throughout life). Gamma-delta T cells could be tinkered with in gut microbiome applications, to treat cardiovascular diseases, and to neutralize antibiotic-resistant infections. But the nearest commercial target of the mysterious immune cells is likely to be treating solid tumor cancers.

They possess potent anti-tumor activity where current immunotherapies fail, such as attacking cancer cells that lack tumor-specific antigens to target or that have become immune to checkpoint inhibitors. In fact, there's a link between certain cancer outcomes and the activity of specific gamma-delta T cells.

Given that, why would Celgene amend the agreement to ditch the rare subset of immune cells? Well, in August 2019, Celgene inked with a start-up called Immatics to develop engineered TCRs. The start-up's platform is based on gamma-delta tech.

Don't feel too bad for Editas Medicine, though. SEC filings reveal that the gene-editing pioneer didn't receive any money from the original collaboration deal with Celgene in the first nine months of 2019. That suggests the work had stalled or that the amendment was being hammered out for some time. The gene-editing pioneer wrestled back control of the tech and took a $70 million upfront payment to boot. While the potential milestone payments in the amended agreement are significantly lower than the originally promised bounty, Editas Medicine can offset that by signing a lucrative collaboration deal with a new partner.

There should be plenty of interest. Fellow gamma-delta T cell developer Adicet Bio recently landed an $80 million series B round funded in part by Johnson & Johnson, Regeneron,Samsung Biologics(not the same company as the electronics powerhouse), and Novartis. There's also Immatics, GammaDelta Therapeutics, and a handful of other start-ups making noise in the space.

Some competitors are directly engineering gamma-delta cells, and others are developing molecules to trigger the immune cells into action. Editas Medicine believes it has the edge, as it has a relatively precise and efficient method for engineering immune cells: gene editing.

The amended collaboration deal between Editas Medicine and Celgene received relatively little attention from investors. Perhaps that was a good thing, as Wall Street likely would have overreacted to the reduced scope of development and milestones. But investors that take the time to understand the details might be intrigued by the new research avenue for the gene-editing stock.

Can Editas Medicine become a leading force in gamma-delta T cell development? Perhaps. While it isn't the only company wielding a gene-editing platform, and CRISPR gene editing isn't the only type of gene editing, the company is well-positioned to take advantage of the opportunity. Investors will have to wait to see how (or if) the development strategy evolves around the new tech.

Originally posted here:
Celgene Gave This Tech Back to Editas Medicine, but It Could Prove Valuable - The Motley Fool

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No Harm, No Foul What If Darwinism Were Excised from Biology? – Discovery Institute

December 8th, 2019 11:47 am

Some biologists might shudder at the thought of eliminating Darwinism from their scientific work. A Darwin-ectomy sounds more painful than a tonsillectomy or appendectomy. To hard-core evolutionists, it might sound like a cephalectomy (removal of the head)! If Darwinism is as essential to biology as Richard Dawkins or Jerry Coyne argues, then removing evolutionary words and concepts should make research incomprehensible.

If, on the other hand, Darwinism is more of a narrative gloss applied to the conclusions after the scientific work is done, as the late Philip Skell observed, then biology would survive the operation just fine. It might even be healthier, slimmed down after disposing of unnecessary philosophical baggage. Here are some recent scientific papers in the Proceedings of the National Academy of Sciences (PNAS) to use as test cases.

In PNAS recently, Adam C. Soloff and Michael T. Lotze reviewed findings by Liu et al. about the immune system. Suffused within the narrative is plenty of Darwinspeak. Does it add anything of value?

Immunity evolved as an impossibly elegant, yet devastatingly destructive force to combat pathogens, environmental insults, and rogue malignant cellular agents arising from within. The immunologic arsenal developed in a veritable coevolutionary arms race with the worlds pathogens, culminating in lymphocytic weapons of mass destruction. Indeed, T cells and B cells endowed with antigen specificity, the capacity for clonal expansion, and most importantly, long-lived memory, represent the pinnacle of such evolution. Together with the innate immune response, the adaptive immune system holds the power to mediate sustained inflammatory responses with such voracity that tissues, organs, or the host itself may endure critical collateral damage. To preserve balance, adaptive immunity has developed under the guiding principle of primum non nocere, or first, to do no harm, limiting the aggression of the innate immune response (e.g., septic shock, penumbra of cerebrovascular and brain infarcts). Herein, redundant mechanisms to preclude aberrant deleterious immunity have evolved as the predominant state of being, establishing a significant molecular and cellular threshold to initiate and maintain inflammation. Often overlooked, following the excitement of the active immune response, are the critical means by which the host resolves the inflammatory process, restoring local and systemic balance. The findings by Liu et al. provide further description of molecular processes and cellular mediators of the resolution process, shedding light on mechanistic aspects of immune homeostasis. [Emphasis added.]

What, exactly, does the e-word evolved add to the understanding of the adaptive immune system? It adds fat, not meat. The essential parts of the explanation could be conveyed easily without Darwin. Basically,

Isnt that cleaner? The reader can breathe easier without the smoke of being told over and over that all these elegant mechanisms evolved.

Seven biologists looked for convergent evolution between two very different mammals whales and bats that use echolocation. Amir Marcovitz et al., in PNAS, relied on Darwinism for their research. Its right there in the title: A functional enrichment test for molecular convergent evolution finds a clear protein-coding signal in echolocating bats and whales. The researchers found not only phenotypic convergence, but convergence all the way down to protein molecules! Can the findings survive a Darwin-ectomy? Sounds like a tough operation.

Echolocation is a prime example of convergent evolution, the independent gain of similar features in species of different lineages. Is phenotypic convergence driven by underlying molecular convergence? If so, could molecular convergence include contributions from highly constrained, often-pleotropic, coding regions? We develop a generalizable test that offers a resounding yes to both extensively debated questions. Our test highlights molecular convergence in genes regulating the cochlear ganglion of echolocating bats and whales, the skin of aquatic mammals, and the lung of high-altitude mammals. Importantly, the approach correctly dismisses confounding convergence-like patterns, such as those from sequence decay of vision genes in blind subterranean species, and is readily applicable to the thousands of genomes sequenced across the tree of life.

Their work not only relies on Darwinism, but promises to help future research. How could anyone claim that Darwinism is useless to this paper? Actually, its quite easy. Its as easy as showing that any other kind of circular reasoning is useless in science. These seven biologists assumed evolution, and concluded evolution. The observations had nothing to do with it.

Some extreme examples can show the fallacy. Humans and turtles can hold their breath underwater. Is that convergent evolution? Turtles cant think, but humans can. Is that divergent evolution? If tricycles and race cars alike are found to contain both aluminum and iron, did they obtain those through blind, unguided processes? So it is with two very different mammals bats and whales that use sound for echolocation. Neither the similarities nor differences prove convergent evolution (or divergent evolution, for that matter), unless you start with that assumption. Its a non sequitur to conclude they evolved.

You can cherry-pick the evidence to support a previously assumed explanation. In this paper, against a backdrop of previous failures to find convergence at the molecular level, the team celebrates their discovery of gene enrichment for cochlear ganglion, lung, and skin but not for a multitude of other traits that should have converged, such as for pharynx, sound generation, and behavior. Even at that, their findings are statistical, not causal, and fail to include potential non-coding influences on the genes. If bats and dolphins were found to use completely different proteins for the cochlear ganglion, the authors would undoubtedly have explained that by evolution, too. No matter how similar or different the animals are in other respects, the conclusion is predetermined: they evolved the common trait, as well as the different traits. In this game, evolutionists cant lose.

Oh yes, this approach will surely help evolutionists with their future research. All they have to do is apply circular reasoning, too. Science marches on!

The paper could be completely revamped without references to evolution, and would be better for it. The researchers could have learned from the similarities and differences in bats and whales, studied the design principles for echolocation in air compared to echolocation in water, and applied the knowledge to human sonar or ultrasonic sensing. Without the evolutionary fat, the science would be useful and productive for human flourishing. Instead, the biologists wasted time on a myth that blind, unguided processes can take sound and build complex systems that can utilize it. Thats ridiculous. Anyone who has watched Illustras detailed animation of dolphin echolocation should realize that sound has no such creative power.

It would seem an impossible challenge to research Darwins finches without reference to Darwin or Darwinism. Yet in their latest paper in PNAS, Peter and Rosemary Grant, who have spent their careers studying these icons of evolution, once again show that science has no need for the Darwin hypothesis. In fact, they created more problems for Darwinism than support.

Adaptive radiations, comprising many species derived from one or a small number of ancestral species in a geologically short time, are prominent components of the worlds biodiversity. Introgressive hybridization of divergent species has been important in increasing variation, leading to new morphologies and even new species, but how that happens throughout evolutionary history is not known. A long-term field study of Darwins finches on Daphne Major island, Galpagos, shows that introgression enhances variation and increases the potential for future evolution. We use a dated phylogeny to infer that populations became more variable in morphological traits through time, consistent with this enhancement effect, and then declined in variation after reaching a maximum. Introgression may be especially important with future climate change.

It will take some radical surgery to remove the Darwinian concepts in the Grants paper, but will the science survive? Take a closer look at what they actually found. First of all, they admit that the effect of introgressive hybridization on adaptive radiation is not known. Ponder that for a moment. After 160 years, has Darwinism been so useless that it has not shed light on a process that should have been well known by now, particularly with these iconic birds? Even worse, though, is that introgression and hybridization involve shuffling existing genetic information. It has nothing to do with variation by random mutation being selected by a blind watchmaker, much less being able to build an irreducibly complex system. Search for selection in the paper and you find only faith, not evidence, that natural selection might work in tandem with introgressive hybridization to produce new species. The only examples of selection they offer involve microevolution, not innovation. For those, they do lateral passes to other Darwinists in the references.

Finally, the finches are still finches. In Darwin Devolves, Behe argues that all species of finches can vary up to the family level without supporting Darwinism. The variations observed by the Grants amount to dimes and pennies in hundred-thousand-dollar transactions, he quips. And did you notice the Grants admitting that the finches variability declined after reaching a maximum? How is that going to fit Darwinism, which requires unlimited variability and progress?

The research on these beautiful, well-designed birds could have been done by someone like Gregor Mendel, who found discrete shuffling of existing traits in peas instead of blending inheritance that Darwin expected. Students could learn about how the shuffling occurs, permitting the birds to survive in oscillating conditions. They could learn about how adaptation of complex systems to changing environments requires Foresight, as Marcos Eberlin has shown. The work of Peter and Rosemary Grant on Darwins finches has offered nothing of substance to support Darwins theory, despite the name. They have not shown that natural selection (even if assumed to have creative power) can surpass the family level and proceed upward to make human brains from bacteria. As confirmation of Darwinism, it has been a tragic waste of time. But all is not lost. Their work has been very helpful to design advocates, showing that, at best, Darwinism can add a millimeter to a bird beak here and there, until the drought ends.

So, here are three papers in Americas premier science journal that appear at first glance to need Darwinism, use Darwinism, support Darwinism, and thereby impart useful scientific knowledge. After subjecting them to Darwin-ectomies, though, the science not only survived, but proved healthier and more useful. Science will do better without the useless fat thinking that blind, unguided processes can account for bats, whales, and immune systems.

Photo: Dolphins of the Galpagos Islands, by Gregory Slobirdr Smith [CC BY-SA 2.0], via Wikimedia Commons.

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No Harm, No Foul What If Darwinism Were Excised from Biology? - Discovery Institute

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These blood markers may indicate a higher risk of disease and death – Medical News Today

December 8th, 2019 11:47 am

A new study suggests that some readings from routine blood tests could help identify people at higher risk of disease and death related to disease. Doctors currently use the readings as markers of immune condition and inflammation.

The study investigators analyzed 12 years of data from 31,178 participants in the National Health and Nutrition Examination Survey (NHANES).

They found that those with low levels of lymphocytes, a type of white blood cell, were more likely to die from heart disease, cancer, and respiratory illnesses, such as pneumonia and influenza.

The analysis showed that the link between low lymphocytes a condition called lymphopenia and higher risk of disease and death did not vary with age or other common risk factors.

However, the predictive power of the low lymphocyte count increased when the scientists added two other measures of blood abnormality: one relating to inflammation and the other to the ability to maintain a supply of red blood cells.

The research is the work of teams from the University Hospitals Cleveland Medical Center, in Ohio, and other institutions. They report their findings in a recent JAMA Network Open paper.

"Scientists have gone to great lengths and expense to develop novel biomarkers to identify people at the highest risk for death and disease," says study author Jarrod E. Dalton, Ph.D., who co-led the investigation.

"Here," he adds, "we have taken a more pragmatic approach investigating the predictive power of components of a patient's white blood cell count, which is collected as part of routine blood work during standard health exams."

Dalton is an epidemiologist at the Cleveland Clinic's Lerner Research Institute.

In their study paper, he and colleagues remark on the increasing availability of drugs that target the immune system to treat established disease. These treatments seek to either reduce or boost immune activity, depending on the underlying relationship to disease.

However, they urge that there is also a great and unmet need for tools and methods to help prevent immune-related diseases in the general population in the first place.

Around 2040% of white blood cells are lymphocytes. A shortage of lymphocytes leaves the body susceptible to infection.

While scientists have recognized that a low lymphocyte count is a strong risk factor for premature death in people with a particular heart valve condition, there has been little research on its value as a more general predictor of survival.

In the new study, the researchers wished to discover whether lymphocyte counts could be an effective way to assess the risk of disease and disease-related death in a nationally representative adult population.

They performed the analysis with lymphocyte count on its own, then together with two other markers.

The two additional markers were red blood cell distribution width (RDW) and C-reactive protein (CRP).

RDW is a measure of how well the body can produce and maintain a healthy supply of red blood cells. CRP is a marker of inflammation.

The analysis linked low lymphocyte count with reduced survival both on its own and in conjunction with other blood markers, especially RDW and CRP.

From the analysis, the researchers conclude that around 20% of the general adult population of the United States appear to have a high risk profile, according to these markers.

In addition, they calculated that the chance of dying within the next 10 years for those with the highest risk profiles was 28%, compared with only 4% for those with the lowest risk profiles.

The team suggests that with more research, it should soon be possible to understand the biological nature of the relationship between these markers and disease. Such knowledge could help identify suitable treatment targets.

In the meantime, it should be possible to help doctors use the markers to identify those with the highest risk of premature death as part of routine preventive care and screening.

"The complete blood count test is convenient, inexpensive, and as our findings suggest may be used to help physicians screen for and prevent disease and disease-related mortality."

Jarrod E. Dalton, Ph.D.

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These blood markers may indicate a higher risk of disease and death - Medical News Today

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