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The Future of Personal and Planetary Well Being : An invitation to Sages and Scientists Symposium, Crystal Bridges Museum, Bentonville Arkansas -…

November 5th, 2019 2:49 pm

Deepak Chopra, Special to SFGate

By Deepak Chopra, MD

Despite a steady increase in life expectancy, medical science is facing diminishing returns. It has been estimated that every increase in lifespan since 1990 has resulted in only ten months of increased healthy life; the rest is only prolonged suffering and the decline of aging. Globally more people now die of so-called lifestyle diseases than from infectious diseases. Doctors cannot make choices about lifestyle; only the patient can. Finally, half of all heart attacks before old age occur in people who live a good lifestyle, managing their weight, eating right, and exercising regularly.

What lies beyond lifestyle? Thats a matter of much speculation. Will human existence be improved in the future through technology, genetic manipulation, nano-robots in the bloodstream serving as cancer hunters? Or will it take a new philosophical conception, one that entices people away from a life of speed, constant activity, and stress?

By all odds it will take both, because innovations in technology cant succeed if we continue to define well-being in old, outworn ways. Consider the following statements, which almost everyone, including doctors, take as fact:

In reality none of these statements is correct. The body isnt a machine; machines cannot heal themselves. The body isnt mindless; every cell is imbued with vast knowledge that far surpasses anything found in medical textbooks. The brain doesnt produce the mind; thats merely an assumption that has never been proved.

The most urgent need facing each of us is how to envision our bodies without the burden of outworn assumptions, which is why, starting in two weeks, an annual symposium known as Sages & Scientists Symposium will bring together the best thinkers with views both humanistic and scientific. This years theme is The Future of Well-Being, and the public is invited to attend. There is nothing on the planet as open to the free exchange of ideas, from every kind of thinker and researcher, all aiming to find a way forward into a viable future.

In my view a total rethink of the human body is long past due. To begin with, the division between mind and body is totally arbitrary. The body is a super-highway of information traveling to every cell, and thousands of different molecules inside a cell know exactly what their precise function is. The bodys ability to heal, along with the immune systems encyclopedic knowledge of all the disease organisms our ancestors encountered (and defeated), far exceeds current medicine.

To get real about your body, you need to see it as a bodymind, a wholeness whose capacity for survival is only exceeded by its capacity to evolve. As the British physicist David Deutsch pointed out in a TED talk this past April, human beings have freed ourselves from the laws of nature that govern the physical universe, and this freedom has allowed us to define entirely how our future will look. Thats a startling reinvention of what it means to be human, because everyone assumes that the laws of nature are vastly more powerful than human beings.

In reality the possibilities created in our consciousness are infinite, but we will remain limited, insecure, and fearful until a new vision tells us who we really are. The body is as conscious as any thought, which is why bodymind is the right conception of our wholeness. Consciousness creates, governs, and organizes every process in the bodymind, and the source of this unlimited knowledge is you. There is no higher power or law of nature dictating your future. The limitations we ascribe to illness, aging, and death are largely mind-made, and the worst of these limitations is our belief that we must be limited.

In reality there is no must about it. The reason science talks about biology as destiny and evolutionists talk about humans as higher apes rests upon a deeply rooted mistake, that we are physical creations glommed together from bits and pieces of matter. This is the same as saying that a masterpiece by Leonardo da Vinci or Picasso is just daubs of oil paint. The entire point of a great painting is the consciousness that goes into it, fashioning beauty and meaning first and foremost.

Likewise, human beings are conscious agents whose existence, first and foremost, is rooted in beauty and meaning also, to which can be added everything else we most value: love, compassion discovery, curiosity, creativity, and evolution. These are aspects of consciousness, and the bodymind is our vehicle for exploring them. The future will be viable only if we have the confidence to see ourselves as expressions of higher consciousness.

I inaugurated Sages & Scientists Symposium so that the best thinkers would feel comfortable in each others company. Instead of compartmentalization, which is the norm in the academic world, there is a free and open field in which anything, from artificial intelligence to Vedanta, from virtual reality to epigenetics, is given time and space to be expressed. The concept has borne fruit beyond anything I originally envisioned. Now it can be truly said that well-being has a future and not simply a repeat of the past. The only way to know if human potential is unlimited is to test it through unlimited imagination, discovery, and deep understanding. The sooner every individual grasps this, the more we can live in hope and optimism.

Deepak Chopra MD, FACP, founder ofThe Chopra Foundationand founder of Chopra Global and co-founder of Jiyo, is a world-renowned pioneer in integrative medicine and personal transformation, and is Board Certified in Internal Medicine, Endocrinology and Metabolism. He is a Fellow of the American College of Physicians and a member of the American Association of Clinical Endocrinologists and Clinical Professor of Family Medicine and Public Health at the University of California, San Diego. Chopra is the author of more than 85 books translated into over 43 languages, including numerous New York Times bestsellers. His latest book is Metahuman: Unleashing Your Infinite Potential. Chopra hosts a new podcast Infinite Potential and Daily Breath available on iTunes or Spotifywww.deepakchopra.com

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Want to be a better person? Meditation is not enough. – Thrive Global

November 5th, 2019 2:49 pm

Photo byZoltan TasionUnsplash

For about 7 years, our team, now known as YogaX , has been promoting the integrative nature of yoga practice and philosophy. We have demonstrated via research that integrated yoga can be helpful in the fields of medicine, psychology, and physical exercise. It is now becoming clear that our emphasis on teaching a yoga that is inclusive of holistic lifestyle practices is also important to the field of mindfulness. Over the past decades, mindfulness has emerged as a powerful intervention in many contexts. Thanks to influential scientists, such as Jon Kabbat-Zin and Rick Hanson, and technology solutions, such as Calm, Headspace, and Insight Timer, mindfulness has become a widely-accepted and common practice.

Mindfulnesshas achieved a can-do-no-harmreputation. However, have you ever met adaily meditator who creates harm, lacks awareness, demands attention, fishesfor compliments, or plays on a phone through a conversation? Of course, we all have! Meditation cannotexcuse us from being human and it is not a complete solution for lifeimprovement.

Psychologicalresearch asserts that awareness is necessary but not sufficient forchange. Mindfulness is often practiced asan attention-strengthening activity. Forexample, the act of listening to a meditation for 5 minutes in the morning ornoticing your breathing for 10 minutes after lunch helps build the capacity forpaying attention. Enhanced attention isincredibly helpful and a necessary ingredient for change. However, without a path to help place attentionon life practices that create harmony and purpose, attention is simply noticing;in and of itself, it not transformed into change.

A recent article by Eric Dolan in PsyPost this August (link here) reviewed a study demonstrating that the non-judgmental practice of mindfulness may actually increase immoral behavior in meditators. The study involved 714 German adults (Study linked here) assigned to a brief mindfulness meditation practice or listened to a control recording. Participants assigned to the mindfulness condition showed less effort toward repairing damage, for example, after losing a friends bicycle. One possible explanation is that non-reactiveness facilitated by meditation reduced negative feelings caused by losing the bicycle. This reduction in negative affect may have resulted in less effort to repair the relationship and make amends.

Although researchers continue to question and explore themechanism of action that might have given rise to this finding, the point iswell taken. Mindfulness by itself doesnot provide guidance about how to live an ethical life. It is designed to increase the capacity forawareness and concentration. While theseskills have a number of standalone benefits, including decreased stress andstress-related physical reactions, they are not skills that necessarilytranslate into ethical or moral action.

Yoga philosophy, on the other hand, treats mindfulness asonly one part of a larger system of living called the eight limbs of yoga. The eight limbs of yoga detail a path towardsawakening, the final state of meditative consciousness. The eight limbs are as follows:

Limb 1 Yamas: ethical life choices

Limb 2 Niyamas: disciplined lifestyle

Limb 3 Asana: movement and posture

Limb 4 Pranayama: breath and energy awareness

Limb 5 Pratyahara: sense withdrawal to turn inward

Limb 6 Dharana: concentration

Limb 7 Dhyana: meditation

Limb 8 Samadhi: absorption or union with a greater whole

The foundational practices of the eight limbs are the ethicaland disciplined lifestyle choices (called the Yamas and Niyamas, which you canread about in our blog). Yoga ethics encourage us to promotepeacefulness (non-harming), truthfulness, non-stealing, moderation, andnon-passiveness. Yoga discipline guidesus towards living a life of purity, contentment, discipline, self-reflectionand dedication to the greater good.These practices lay the necessary foundation and create a helpfulcontainer for the development of breath work, movement, and the inner practicesof concentration and meditation.

In this tradition of yoga, mindfulness and meditation practicesare not recommended until ethical practices, personal discipline, breath awareness,embodied movement, and withdrawal of senses are in place. The contemporary urge is to cultivate mindfulnessas a quick tool that facilitates a better system of living. In yoga, however, mindfulness and meditationare practices that rest on and support a holistic and comprehensive lifestyleof compassion, lovingkindness, and joy.

We hope that these yogic wisdoms widen your understanding ofmindfulness and to consider situating your mindfulness practice within a largersystem of living that includes self-inquiry, breathing, and physicalpractice. This holistic approach mightjust enhance your experience of meditation and make you a better person in theprocess.

Thank you for reading.

YogaX

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Want to be a better person? Meditation is not enough. - Thrive Global

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blocked growth of J&K higher education institutions: Singh – IndiaPost.com

November 5th, 2019 2:49 pm

KATRA (J&K): Union minister Jitendra Singh on Monday said Article 370, which gave special status to Jammu and Kashmir, had blocked the growth of higher education in the erstwhile state, and halted the academic institutions to evolve at par with those in the rest of India.

Singh said even though Prime Minister Narendra Modi gave highest priority to the state and the Centre went out of the way to approve new institutions of higher education, growth of such institutions got thwarted by the vested interests using the bogey of Article 370.

The minister of state in the Prime Ministers Office (PMO) was addressing the inaugural session of the three-day international conference on applied biology and biotechnology at the Shri Mata Vaishno Devi University (SMVDU).

In the past five years, Singh said, the state was given two All India Institute of Medical Sciences (AIIMS), an Indian Institute of Management (IIM) and Indian Institute of Technology (IIT), nearly eight centrally-funded medical colleges, including three of them in his parliamentary constituency of Udhampur.

The minister said these institutions failed to pick up because of lack of faculty and lack of research module despite liberal funding from the Modi government,

According to Singh, for any university or institute of higher education to grow, the basic prerequisites include exclusive department or streams of study for research and high standards of research publications, which, in turn, depend upon eminent faculty members selected purely on the basis of merit.

However, the minister added, in the garb of Article 370, no eminent faculty was ready to come here because instead of providing them incentives, they were being offered no incentives.

He also took a dig at the votaries of Article 370 for wrongly citing the name of Maharaja Hari Singh, who signed the instrument of accession to merge Jammu and Kashmir into the Union of India in 1947, to support their argument.

The minister said it was Hari Singh who had brought Ram Nath Chopra from Kolkata and offered him the facility and incentive to start the drug research laboratory (DRL), which is now known as the Indian Institute of Integrative Medicine (IIIM), Jammu, and is one of the important nationally-renowned institutions.

Much before Independence, he said, Hari Singh used to ensure best of the teaching faculty from outside for the then Prince of Wales College at Jammu.Jitendra Singh emphasised the need to go for the best faculty from any part of the country without any compromise. He suggested greater collaboration of the university with other eminent academic institutions in the region, which according to him, could help in value addition to the education standards. PTI

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Dr. David Friedman’s book Food Sanity wins first place at the Author Academy Awards – PR Web

November 5th, 2019 2:49 pm

WILMINGTON, N.C. (PRWEB) November 04, 2019

Over a thousand authors worldwide were nominated for their work in one of 16 categories. Entries were reviewed and evaluated on popular vote, social contribution, and overall presentation (cover, content, flow, and originality) by a panel of select judges.

Friedman presented his book synopsis at the Author Academy Awards Red Carpet Sessions, which was then followed by a Red Carpet Meet and Greet, and the Author Academy Awards Ceremony.While other winners thanked those that supported and believed in them, during Friedmans acceptance speech, he thanked those that did not believe in him. This included the agents and publishers that told him his book wasnt worthy of being published. Dr. Friedman shared how he turned this REJECTION into REDIRECTION which motivated him to work even harder. The results paid off and Food Sanity went on to become an international award-winning, #1 best-selling book. After giving a shout out to those that decided not to publish Food Sanity, Friedman held up his award and said, In the words of Julia Roberts from Pretty woman, Big Mistake!

Kary Oberbrunner, founder of the Author Academy Awards said, The Author Academy Awards is an honor bestowed for literary merit and publishing excellence in the writing and publishing industry. Our goal is to help further connect this global community of authors, and maintain excellence and integrity of the book publishing industry.

"It's truly been a 'pinch me' year!" Dr. Friedman says." It took six years to research over one thousand clinical studies and interview hundreds of scientists and renowned doctors before Food Sanity came to fruition. Being an Author Academy Award winner will further help my mission to change the world one plate at a time.

Jack Canfield, New York Time's best-selling author of Chicken Soup for The Soul, says, "I'm very impressed with the level or research Dr. Friedman has done and how he's integrated this information into helping people, including me! With so much confusion and contraindications on what we should and shouldn't be eating, Food Sanity will add more years to your life and life to those years."

About Dr. David Friedman:Dr. David Friedman is a multiple award-winning, #1 national best-selling author of Food Sanity, how to eat in a world of fads and fiction (Turner Publishing.) He's a Doctor of Naturopathy, Clinical Nutritionist and Chiropractic Neurologist. He received a post-doctorate certification from Harvard Medical School, is a Board Certified Alternative Medical Practitioner and Board Certified in Integrative Medicine. He's a former teacher of neurology and author of the college textbook, "Understanding the Nervous System." As the Health Expert for Lifetime Television's morning show and host of To Your Good Health Radio, millions of people have enjoyed his weekly, cutting-edge health features. Dr. Friedman is also a contributing writer for many leading news, health and fitness magazines including U.S News & World Report, Newsweek, Readers Digest, Better Nutrition, Mind Body Green, AARP Magazine, and Saturday Evening Post, just to name a few. For more information about Dr. David Friedman visit: DrDavidFriedman.com

About the Author Academy AwardsThe Author Academy Awards is an award bestowed for literary merit and publishing excellence in the writing and publishing industry. It is presented annually by Author Academy Elite, a premium service provider for authors, at the Author Academy Awards Ceremony. For more information on the awards, visit AuthorAcademy.com

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Lecture: The Natural Path to Boosting Immunity and Mood – New Canaan Advertiser

November 5th, 2019 2:49 pm

Updated 5:02pm EST, Monday, November 4, 2019

Photo: Contributed Photo.

New Canaan Library seeks natural path to well-being

Winter is fast approaching and while many enjoy the New England change of seasons, the winter months also bring the challenge of preserving good health and mood. New Canaan Library welcomes nutritionist/dietiian Jay Wolkoff, who will discuss how integrative and natural strategies can boost immunity and ones overall sense of well-being on Sunday, Nov. 10, at 2 p.m. in the Adrian Lamb Room. To register, visit newcanaanlibrary.org.

While modern-day living allows us to largely insulate ourselves from the outdoors and enjoy produce from temperate and tropical climates, there also is a certain beauty to acclimating our bodies to the cooler months with warming foods, herbs, and spices, an announcement said. In his presentation, Jay Wolkoff uses his extensive knowledge of nutrition and the sciences combined with integrative strategies to demonstrate how one can support his or her bodys natural immunity as well as keep his or her mood up during the darker and cooler months.

Wolkoff, nutritionist/dietician, MS, CNS, CDN, is passionate about providing individualized and comprehensive dietary and lifestyle support to his clients, the announcement said. His approach toward health effortlessly weaves together his background in evidence-based nutrition and the emerging sciences, clinical herbalism, appreciation for mind-body medicine, passion for organic gardening, and love of the outdoors, the announcement said.

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Lecture: The Natural Path to Boosting Immunity and Mood - New Canaan Advertiser

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Anivive and Basepaws form new partnership to study feline genetics and diabetes – Yahoo Finance

November 5th, 2019 2:48 pm

LONG BEACH, Calif., Nov. 5, 2019 /PRNewswire/ --Anivive Lifesciences, a pet pharmaceutical company, and Basepaws, a pet DNA sequencing company, have formed a new partnership to study feline genetics and diabetes. The companies are encouraging veterinarians and cat owners interested in participating to sign up on AniviveTrial.com.

Anivive and Basepaws Logos

"Participants will not only be helping advance feline diabetes research, but they will also receive a free genetic breed and health report about their cat," said Anivive's Founder and CEO, Dylan Balsz. "We are excited to work directly with cat owners to increase our understanding of diabetes. This partnership underscores how Anivive's software is accelerating the development of new pet medicines."

"Feline diabetes is a growing problem, but available treatments are expensive and rely mostly on symptom control through insulin therapy and dietary management," explained Anivive's Chief Medical Officer David Bruyette, DVM, DACVIM. "There is currently no clear understanding of the contribution of genetic factors to feline diabetes. This study offers cat owners the opportunity to take a direct role in developing genetics-based precision medicine tools aiming to improve and extend the lives of diabetic cats."

Beginning today, owners can visit AniviveTrial.com to complete a short survey about their cat's health. Anivive will mail eligible participants a free DNA collection kit. After collecting a DNA sample (a single saliva swab from their cat's mouth), owners mail the kit back with pre-paid postage. Anivive and Basepaws are covering the entire cost of the study, including the genetic test ($129 value).

"As a consumer pet health company, we focus on partnering with innovative companies like Anivive, who are leading research to advance our understanding of feline biology and improve the health management of cats around the world," said Basepaws' Chief Veterinary Officer Chris Menges, DVM, MPH.

Pet owners and their cats will help advance the development of new, targeted and potentially disease-modifying therapies, as well as genetics-based diagnostic tools for feline diabetes.

To learn more about this exciting new partnership and to join the movement to advance feline healthcare, please visit AniviveTrial.com/CatDNA.

About AniviveAnivive Lifesciences is a veterinary pharmaceutical company focused on reshaping pet healthcare by bringing together experts in software development, veterinary medicine, and clinical research to accelerate the development of novel pet therapeutics. Currently, only 15% of pet diseases and conditions have an approved veterinary treatment. We create therapeutics for the other 85%. Anivive. "Smarter for pet health."

About BasepawsBasepaws is a personalized pet health company that has developed the first consumer genetics test for cats. With a mission to improve and extend the lives of pets everywhere and help foster stronger bonds between humans and their pets, Basepaws offers pet owners insights into their cat's unique background, including detailed information about breeds, traits, health, and genetic markers for hereditary diseases. With new data from each CatKit completed, Basepaws' database continues to provide new and valuable information into genetic correlations and cat-specific diseases.

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Why Didnt She Get Alzheimers? The Answer Could Hold a Key to Fighting the Disease – The New York Times

November 5th, 2019 2:48 pm

When you have delayed onset of Alzheimers by three decades, you say wow, said Dr. Bu, chairman of the neuroscience department at the Mayo Clinic in Jacksonville, Fla., who was not involved in the study.

He said the research suggests that instead of drugs attacking amyloid or tau, which have failed in many clinical trials, a medication or gene therapy targeting APOE could be promising.

Dr. Reiman, who led another newly published study showing that APOE has a bigger effect on a persons risk of getting Alzheimers than previously thought, said potential treatments could try to reduce or even silence APOE activity in the brain. People born without APOE appear to have no cognitive problems, but they do have very high cholesterol that requires treatment.

Dr. Huang, who co-wrote a commentary about the study and is affiliated with two companies focusing on potential APOE-related treatments, said the findings also challenge a leading Alzheimers theory about the role of amyloid.

Since the woman had huge amounts of amyloid but few other Alzheimers indicators, it actually illustrates, to my knowledge for the first time, a very clear dissociation of amyloid accumulation from tau pathology, neurodegeneration and even cognitive decline, he said.

Dr. Lopera said the woman is just beginning to develop dementia, and he recently disclosed her genetic profile to her four adult children, who each have only one copy of the Christchurch mutation.

The researchers are also evaluating a few other members of the Colombian family, who appear to also have some resistance to Alzheimers. They are not as old as the woman, and they do not have the Christchurch mutation, but the team hopes to find other genetic factors from studying them and examine whether those factors operate along the same or different biological pathways, Dr. Reiman said.

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Anivive, Basepaws Partner to Study Feline Genetics and Diabetes – Pet Age

November 5th, 2019 2:48 pm

Press release: Anivive Lifesciences

Anivive Lifesciences, a pet pharmaceutical company, and Basepaws, a pet DNA sequencing company, have formed a new partnership to study feline genetics and diabetes. The companies are encouraging veterinarians and cat owners interested in participating to sign up online.

Participants will not only be helping advance feline diabetes research, but they will also receive a free genetic breed and health report about their cat, said Anivives founder and CEO, Dylan Balsz. We are excited to work directly with cat owners to increase our understanding of diabetes. This partnership underscores how Anivives software is accelerating the development of new pet medicines.

Feline diabetes is a growing problem, but available treatments are expensive and rely mostly on symptom control through insulin therapy and dietary management, explained Anivives chief medical officer David Bruyette, DVM, DACVIM. There is currently no clear understanding of the contribution of genetic factors to feline diabetes. This study offers cat owners the opportunity to take a direct role in developing genetics-based precision medicine tools aiming to improve and extend the lives of diabetic cats.

Beginning today, owners can visit the website to complete a short survey about their cats health. Anivive will mail eligible participants a free DNA collection kit. After collecting a DNA sample (a single saliva swab from their cats mouth), owners mail the kit back with pre-paid postage. Anivive and Basepaws are covering the entire cost of the study, including the genetic test ($129 value).

As a consumer pet health company, we focus on partnering with innovative companies like Anivive, who are leading research to advance our understanding of feline biology and improve the health management of cats around the world, said Basepaws chief veterinary officer Chris Menges, DVM, MPH.

Pet owners and their cats will help advance the development of new, targeted and potentially disease-modifying therapies, as well as genetics-based diagnostic tools for feline diabetes.

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Anivive, Basepaws Partner to Study Feline Genetics and Diabetes - Pet Age

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First-of-its-kind study reveals genetic traits determining coat colors and physical appearance in over 200 dog breeds – PRNewswire

November 5th, 2019 2:48 pm

VANCOUVER, Wash., Nov. 4, 2019 /PRNewswire/ -- Wisdom Health - the world's leader in pet genetics and researchers at Purdue University today announced the most comprehensive study of dog coat color and physical trait genes ever conducted is published in PLOS ONE. The study "True Colors: commercially-acquired morphological genotypes reveal hidden allele variation among dog breeds, informing both trait ancestry and breed potential" found that many dog breeds carry gene variants for unexpected physical traits such as coat colors, which could randomly appear in future generations.

Thanks to the increasing popularity of at-home pet genetic testing, researchers utilized Wisdom Health's extensive database to provide insight into the physical trait variation of nearly 12,000 purebred dogs from 212 breeds, along with four wild canine species.

"As our study demonstrates, purebred dogs have so much more than meets the eye - literally. The information provided by a WISDOM PANEL dog DNA test can help us better understand the hidden elements of dog genetics," said Dr. Angela Hughes DVM PhD, veterinarian and canine genetics expert at Wisdom Health. "While our study focused primarily on purebred populations, these hidden traits can also have ramifications for mixed breed dogs. When unexpected or hidden traits are passed to mixed breed dogs from their purebred ancestors, it further complicates the already difficult task of visual breed identification making DNA tests the only reliable method of determining breed ancestry."

The study also found that the frequency of hidden gene variants in purebred dogs could provide information about the history and relatedness of certain seemingly disparate breeds - such as the Australian Shepherd and the Airedale Terrier.

"We used previously-identified genetic links between breeds to map a potential route of gene variant dispersal, such as the tailless gene variant that exists in both the Australian Shepherd and Airedale Terrier," said Dr. Kari Ekenstedt DVM PhD, assistant professor and dog genetics researcher at Purdue University's College of Veterinary Medicine. "Through genetic relationship analysis of purebred populations, we can examine the distribution of specific coat color and trait variations and help estimate a time frame for when these variations first came about. For instance, the presence of a particular allele in a wide variety of dog breeds suggests that the variant existed within domestic dogs well before pure breed development roughly 200 years ago."

Most important for future research, the study provides a baseline of trait frequency data for a given population of purebred dogs. Based on these findings, breeders can utilize DNA panel testing to identify their desired traits and avoid expression of undesirable traits in future litters.

"In many cases, the frequency of undesirable trait variants within a breed is very low. But the genetic potential to produce those traits exists, and knowing this potential can help breeders and breed organizations make informed decisions going forward," said Dr. Dayna Dreger PhD, the lead author on the PLOS ONE publication.

Wisdom Health has also simultaneously crossed another major milestone within the pet genetics industry: as of today, more than 1.5 million dogs worldwide have been tested with the WISDOM PANEL test.

"This study reveals the power of genetic testing to uncover the hidden stories of breed relationships and trait distribution across the globe," said Dr. Becca Chodroff Foran PhD, Research & Development Director at Wisdom Health. "With 1.5 million dogs tested with WISDOM PANEL and counting, our research program continues to invest in the development and discovery of actionable genetic insights to better understand and care for our beloved pets."

About the Study

About Wisdom HealthWisdom Health's mission is to facilitate responsible pet care by enhancing the well-being and relationship between pets, pet owners, breeders, shelters and veterinarians through valuable insights into pets as individuals. For more than a decade, Wisdom Health has researched and developed state-of-the-art genetic tests for companion animals, revolutionizing personalized pet care. By unlocking the secrets of their dog or cat's DNA, owners and veterinarians can work together to tailor wellness programs that fit the one-of-a-kind needs of their unique pet. For more information, visit http://www.wisdompanel.com, or follow Wisdom Panel on Facebook, Instagram and Twitter.

About KinshipAdvances in science, technology, health and nutrition offer an opportunity to transform the $100B+ pet care industry. With industry-leading data and analytics capabilities, a $100M venture fund and pioneering startup accelerator program, unique set of technology businesses like Whistle and Wisdom Health,Kinship is building the first-of-its-kind coalition of partners to transform the future of pet care. Kinship is a business division of Mars Petcare, the global leader in pet health, nutrition and services, dedicated to one purpose:A Better World for Pets. Follow @kinshipco to learn more.

About Mars PetcarePart of Mars, Incorporated, a family-owned business with more than a century of history making diverse products and offering services for people and the pets people love, the 85,000 Associates in Mars Petcare are dedicated to one purpose: A BETTER WORLD FOR PETS. With 75 years of experience, our portfolio of almost 50 brands serves the health and nutrition needs of the world's pets including brands PEDIGREE, WHISKAS, ROYAL CANIN, NUTRO, GREENIES, SHEBA, CESAR, IAMS and EUKANUBA as well as The WALTHAM Centre for Pet Nutrition which has advanced research in the nutrition and health of pets for over 50 years. Mars Petcare is also a leading veterinary health provider through a network of over 2,000 pet hospitals including BANFIELD, BLUEPEARL, PET PARTNERS, VCA, Linnaeus and AniCura. We're also active in innovation and technology for pets, with WISDOM PANEL genetic health screening and DNA testing for dogs, the WHISTLE GPS dog tracker, and LEAP VENTURE STUDIO accelerator and COMPANION FUND programs that drive innovation and disruption in the pet care industry. As a family business and guided by our principles, we are privileged with the flexibility to fight for what we believe in and we choose to fight for: A BETTER WORLD FOR PETS.

SOURCE Wisdom Health

https://www.wisdompanel.com

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Exercise May Help Ward Off Depression, Even If You’re Genetically Prone to It – Livescience.com

November 5th, 2019 2:48 pm

Getting a few hours of exercise a week may reduce the risk of depression, even in people who are genetically prone to the condition, a new study suggests.

The authors found that, although certain genes boost a person's risk of depression, increased levels of exercise essentially canceled out this genetic risk.

Overall, for every 4 hours of exercise per week (about 35 minutes per day), participants saw a 17% reduction in their chances of experiencing bouts of depression over the next two years. This protective effect of exercise held even for those at high genetic risk for depression.

Related: 7 Ways Depression Differs in Men and Women

"Our findings strongly suggest that, when it comes to depression, genes are not destiny and that being physically active has the potential to neutralize the added risk of future episodes in individuals who are genetically vulnerable," study lead author Karmel Choi, postdoctoral fellow in psychiatry at Massachusetts General Hospital, said in a statement.

The study is published today (Nov. 5) in the journal Depression and Anxiety.

Depression can run in families, which suggests that genetic factors contribute to the risk of developing the disease, according to the National Institutes of Health (NIH). Although research on the genetics of depression is in its infancy, studies suggest that multiple genes, each with a small effect, combine to increase a person's risk of the disease, according to the NIH.

In addition, previous studies have found that exercise can reduce people's risk of depression. But it wasn't clear if this benefit applied to those with certain risk factors, such as a genetic risk for depression, the authors said.

In the new study, the researchers analyzed information from nearly 8,000 participants in the Partners HealthCare Biobank, a database intended to help researchers better understand how people's genes, environment and lifestyle affect their health. Participants provided a blood sample, had their genomes analyzed and filled out a survey about their lifestyle behaviors, such as how much exercise they typically get in a week. This information was then linked with people's electronic health records (EHRs) within Partners HealthCare, a Boston-based health care system.

To be included in the new study, participants could not be currently depressed, and so the researchers excluded people who had visited a medical professional for depression within the past year. The authors then looked to see which of those remaining participants experienced a new episode of depression based on billing codes from their EHRs within the next two years.

The researchers also used genomic data to calculate a person's genetic risk for depression, and gave people a "score" based on their risk. This allowed the researchers to divide participants into three groups: those with low, intermediate and high genetic risk for depression.

The researchers found that, not surprisingly, those with a high genetic risk for depression were 50% more likely to experience a new episode of depression within the next two years, compared with those at low genetic risk.

However, across all risk groups, people who were more physically active were less likely to experience a new episode of depression. For example, among those in the high-risk group, the incidence of depression was nearly 13% for those who didn't exercise, compared with just 8% for those who exercised for about 3 hours a week.

What's more, both high-intensity exercises, such as running, and low-intensity exercises, such as yoga, were linked with a decreased risk of depression.

However, the study only found an association and cannot prove that a lack of exercise causes depression (although previous research has suggested that exercise likely helps ward off depression). In addition, the EHRs used in the study do not capture the severity of a depressive episode and do not reflect care outside of the Partners HealthCare system.

Still, the study provides "promising evidence" that doctors can use to counsel patients and "make recommendations to patients that here is something meaningful they can do to lower their risk even if they have a family history of depression," Choi said.

Of course, in addition to reducing depression risk, regular exercise has a slew of other health benefits, such as reducing people's risk of heart disease, type 2 diabetes and some cancers, according to the Centers for Disease Control and Prevention (CDC). However, less than a quarter Americans meet national exercise guidelines, according to the CDC's National Center for Health Statistics.

Originally published on Live Science.

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Is Genetic Testing Worth the Time? – Curetoday.com

November 5th, 2019 2:48 pm

Before undergoing genetic testing, stop to consider its effect on your daily experience, including your ability to get life insurance.

A few months later, my moms cancer came back. It had metastasized to her brain and eventually found a home in her bones, liver and lungs. Shortly before her death in late 2005, while we were eating lunch, my mom mentioned that she wished shed gotten more life insurance. This emotional math equation struck me as genuinely morbid. How can you attach a dollar amount to a life missed, time not spent together? What is the cost of a broken heart?

Months after my mother died, a check arrived in the mail. Now, almost 14 years later, the money is long gone. I spent it hosting holidays, on a birthday gift to myself every year for almost a decade, on gifts for my two children when they were born and on the medical bills from breast cancer screenings that my health insurance didnt cover. The last chunk went to the deductible for my preventive mastectomy in 2013. I appreciated every penny and didnt take for granted that I had a decade-long cushion allowing me to do things that would have otherwise been outside my reach. My mothers life insurance money allowed me to take the steps to secure my healthy future.

In 2008, I finally had genetic testing and learned that I didnt have the BRCA mutation. But because of other hereditary risk factors, including a family history of breast cancer, I started regular screening until I decided to pursue surgical intervention.

Over the last year, my preventive oncologist has been suggesting that I undergo expanded panel testing. In the years since my initial testing, many more genetic markers for breast cancer have been discovered. The thought of having more testing sent me into a tailspin at first. My anxious and uneasy feelings recalled the hurricane of emotions I felt when my mom died, when a routine ultrasound revealed I had a breast lump and when I faced a series of emotional choices about surgery and reconstruction. What would I do if I learned I had a mutation that predisposed me to other cancers? Would I need more surgery? What additional foreshadowing would this have for my childrens health? I simply wasnt ready to know.

Even in what can be considered a best-case scenario, in which I was able to make the choice to reduce my cancer risk through surgery, this decision required me to put my whole life on pause. I juggled the logistics of single parenthood, surgery, my job and household management pretty well, though Id be remiss to ignore the army of help I had. However, my life was still affected by many critical things that none of my doctors ever discussed.

The list of things I was unprepared for due to my preventive mastectomy is almost endless. Here are a few examples:

Not a single person suggested that I get life insurance before undergoing genetic testing, nor did it occur to me to consider how it would affect my (and my childrens) ability to get insured until I met a previvor who sells insurance, which brought the topic to the front of my mind. Now, I feel lucky that Ive been putting off a second round of testing, because the delay gives me time to explore our life insurance options.

This process, and the time Im taking to do it, has given me perspective on my experience with screening, mastectomy and reconstruction. In hindsight, I realize that I should have taken more time to ask my doctor questions and brought a friend to take notes. I should have talked with more women about their experience to help guide my choices and better inform me about my options. Now, when I meet women facing these choices, that is the advice I give.

Of course, this lesson about slowing down and being more considerate is one I can use in all areas of my life.

As a breast cancer previvor, Kristen Carbone recognizes the need to feel vital and strong in both mind and body after mastectomy. In 2016, she founded Brilliantly (brilliantly.co), a brand that provides full-spectrum solutions and support to women so they can prosper and reclaim themselves along their journey.

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Healthcast: The importance of genetic testing – KLBK | KAMC | EverythingLubbock.com

November 5th, 2019 2:48 pm

LUBBOCK, Texas Family trees show where youve been.

But the family tree that genetic counselor Julie Beasley shows her patients at Joe Arrington Cancer Center shows what their future could look like.

Genetics is important for everybody no matter your gender, your race, your age, explained Beasley. Genetic testing and family history can play a vital role in healthcare for any role in any race.

She talks to people who have cancer or family history of cancer and helps them figure out if something is hereditary or can expose them to cancer in their family.

Its important to know your family history to get an idea of whats in your family but not just what they were diagnosed with but how old were they or was it a rare type of cancer, Beasley explained.

This testing can help patients get diagnosed earlier or could prevent it all together.

Interpreters are also available for people who dont speak English so they can also understand what is going on.

I think its very important because sometimes theyre scared to come in because of the diagnosis but if they dont completely understand whats going on then they may not be willing to come back, said Delia Rubio, intake coordinator at Covenant Health. This way theyre informed and they know.

Beasley hopes patients will see the importance of genetic testing and how it can benefit people in the future.

If patients know its there we can help them with managing it so they dont worry as much and they can put that behind them, said Beasley.

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GPs urged to inform women about pre-pregnancy genetic testing – The Age

November 5th, 2019 2:48 pm

This is concerning, the study's lead researcher Dr Ruth Leibowitz said, because GPs are the first point of call for most pregnant women and those seeking preconception medical care.

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"One theory is that GPs simply dont really know about the tests and the majority of these tests are being driven by patients requesting it," Dr Leibowitz said during a presentation of her findings at the GP19 conference in Adelaide last Friday.

When prenatal testing shows a fetus is at risk, families are faced with a profound and difficult decision on whether to keep the baby or terminate the pregnancy.

Many couples who are found to be carriers of the mutations prior to pregnancy can use IVF in conjunction with genetic testing of embryos to avoid having a child with a genetic condition.

Of the 21,172 women screened, one in 20 were carriers for at least one of the severe genetic disorders.

About 70 per cent were in the highest socio-economic quartile as measured by residential postcode. About 53 per cent were pregnant at the time of screening.

Earlier this year, the Royal Australian and New Zealand College of Obstetricians and Gynaecologists set new guidelines, recommending that all women planning a pregnancy or in their first trimester should be given information about preconception carrier screening.

But Professor Martin Delatycki, clinical director of the Victorian Clinical Genetics Services and member of the Genomics Advisory Working Group, estimates less than 10 per cent of aspiring parents are offered such screening.

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"What the results show us is that GPs are in an ideal position to offer it because they see women before they are pregnant," Professor Delatycki said.

"When women are not pregnant and they have screening, they have much more time to make a decision if theyre at high risk of having a child with one of the genetic conditions.

"It is very critical its a choice for people, not just a routine test," he said. "Because its not right for everybody.

Royal Australian College of General Practitioners president Harry Nespolon argued the onus should be on obstetricians with the expertise to discuss genetic testing with would-be parents, with many GPs choosing to refer women on to genetic counsellors.

For some patients, testing for the rare conditions went against their belief system, Dr Nespolon said.

"This is not a decision to be taken lightly because there is a lot to consider about requesting genetic screening, ultimately it can affect patients pyschologically and financially. It can affect people quite deeply and the choices they make."

Carrier screening to determine if couples carry the mutations for SMA, cystic fibrosis and fragile X is not routinely offered and many doctors do not know the tests exist.

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Professor Delatycki said recent research pointed to women having a higher chance of having a baby with one of the three genetic conditions, than there is of having a baby with Down Syndrome.

The tests can cost up to $1800 for couples and are not covered by Medicare, prompting concerns that only wealthy aspiring parents can take this precaution in a bid to avoid having a baby with a severe genetic condition.

Fragile X syndrome causes intellectual disability and behavioural and learning challenges, and is also the most common single-gene cause of autism worldwide. Spinal muscular atrophy is a severe muscle-wasting disease, while cystic fibrosis damages the lungs and digestive system.

The landmark Mackenzie's Mission trial has begun recruiting 10,000 Australian couples to be screened for 500 severe and deadly genetic conditions.

The results of the trial are expected to inform whether the federal government will introduce Medicare subsidies for carrier screening.

Melissa Cunningham is The Age's health reporter.

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Seattle Genetics and BeiGene Announce Global License Agreement for Advanced Preclinical Product Candidate – Business Wire

November 5th, 2019 2:48 pm

BOTHELL, Wash. & BEIJING & CAMBRIDGE, Mass.--(BUSINESS WIRE)--Seattle Genetics, Inc. (Nasdaq: SGEN) and BeiGene, Ltd. (Nasdaq: BGNE; HKEX: 06160) today announced that the companies have entered into a license agreement for an advanced preclinical product candidate for treating cancer. The agent utilizes a proprietary Seattle Genetics antibody-based technology and is expected to advance into clinical trials in the first half of 2020.

Under the terms of the agreement, Seattle Genetics has retained rights to the product candidate in the Americas (United States, Canada and Latin American countries), Europe and Japan. BeiGene has been granted exclusive rights to develop and commercialize the product candidate in Asia (except Japan) and the rest of the world. Seattle Genetics will lead global development and BeiGene will fund and operationalize the portion of global clinical trials attributable to its territories. BeiGene will also be responsible for all clinical development and regulatory submissions specific to its territories. Seattle Genetics will receive an upfront payment and is eligible to receive progress-dependent milestones for a total deal value of up to $160 million and tiered royalties on any product sales.

Collaborating with BeiGene on this product candidate has the potential to accelerate its availability both globally and in several key geographic regions, notably China where there is an unmet medical need for anti-cancer therapies, said Roger Dansey, M.D., Chief Medical Officer at Seattle Genetics. BeiGene brings to this collaboration strong clinical and commercial capabilities and a focus on innovative, targeted oncology drugs. We look forward to working together to develop this therapy for patients worldwide.

Seattle Genetics is recognized for its transformative oncology discoveries and we are excited to collaborate on the global development of this new drug candidate. This collaboration ties closely to our mission, to bring meaningful and innovative new medicines to patients around the world, through our commitment to world-class clinical development and commercialization, said Lai Wang, Ph.D., Senior Vice President, Head of Global Research, Clinical Operation & Biometrics and APAC Clinical Development at BeiGene. The pending start of this new global trial adds a complementary molecule to our broad oncology development program, which now includes more than 60 clinical trials around the world.

About Seattle Genetics

Seattle Genetics, Inc. is an emerging multi-product, global biotechnology company that develops and commercializes transformative therapies targeting cancer to make a meaningful difference in peoples lives. ADCETRIS (brentuximab vedotin) utilizes the companys industry-leading antibody-drug conjugate (ADC) technology and is currently approved for the treatment of multiple CD30-expressing lymphomas. Beyond ADCETRIS, the company has a late-stage pipeline including enfortumab vedotin for metastatic urothelial cancer, currently being reviewed for approval by the FDA, and tisotumab vedotin in clinical trials for metastatic cervical cancer, which utilize our proprietary ADC technology. In addition, tucatinib, a small molecule tyrosine kinase inhibitor, is in late-stage development for HER2-positive metastatic breast cancer and in clinical development for metastatic colorectal cancer. We are also leveraging our expertise in empowered antibodies to build a portfolio of proprietary immuno-oncology agents in clinical trials targeting hematologic malignancies and solid tumors. The company is headquartered in Bothell, Washington, and has a European office in Switzerland. For more information on our robust pipeline, visit http://www.seattlegenetics.com and follow @SeattleGenetics on Twitter

About BeiGene

BeiGene is a global, commercial-stage, research-based biotechnology company focused on molecularly-targeted and immuno-oncology cancer therapeutics. With a team of over 3,000 employees in China, the United States, Australia and Europe, BeiGene is advancing a pipeline consisting of novel oral small molecules and monoclonal antibodies for cancer. BeiGene is also working to create combination solutions aimed to have both a meaningful and lasting impact on cancer patients. BeiGene markets ABRAXANE (nanoparticle albuminbound paclitaxel), REVLIMID (lenalidomide), and VIDAZA (azacitidine) in China under a license from Celgene Corporation.i

Seattle Genetics Forward Looking Statements

Certain of the statements made in this press release are forward looking, such as those, among others, relating to the development and commercialization of the specified product candidate and the possible financial payments from BeiGene to Seattle Genetics. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include the risks associated with developing and commercializing novel drug candidates and that the collaboration agreement may be modified, terminated, or not provide anticipated benefits. More information about the risks and uncertainties faced by Seattle Genetics is contained under the caption Risk Factors included in the companys Quarterly Report on Form 10-Q for the quarter ended September 30, 2019 filed with the Securities and Exchange Commission. Seattle Genetics disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.

BeiGene Forward Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 and other federal securities laws, including statements regarding future development and potential commercialization activities of the specified product candidate under the agreement with Seattle Genetics, potential payments payable to Seattle Genetics, the speed and outcome of drug development plans, and other information that is not historical information. Actual results may differ materially from those indicated in the forward-looking statements as a result of various important factors, including BeiGene's ability to demonstrate the efficacy and safety of its drug candidates; the clinical results for its drug candidates, which may not support further development or marketing approval; actions of regulatory agencies, which may affect the initiation, timing and progress of clinical trials and marketing approval; BeiGene's ability to achieve commercial success for its marketed products and drug candidates, if approved; BeiGene's ability to obtain and maintain protection of intellectual property for its technology and drugs; BeiGene's reliance on third parties to conduct drug development, manufacturing and other services; BeiGenes limited operating history and BeiGene's ability to obtain additional funding for operations and to complete the development and commercialization of its drug candidates, as well as those risks more fully discussed in the section entitled Risk Factors in BeiGenes most recent quarterly report on Form 10-Q, as well as discussions of potential risks, uncertainties, and other important factors in BeiGene's subsequent filings with the U.S. Securities and Exchange Commission. All information in this press release is as of the date of this press release, and BeiGene undertakes no duty to update such information unless required by law.

i ABRAXANE, REVLIMID and VIDAZA are registered trademarks of Celgene Corporation.

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Science news in brief: From lab-grown steak to the world’s loudest birdsong – The Independent

November 5th, 2019 2:47 pm

Lab-grown steak gets a little muscle

The alt-meat industry has created quite a sizzle, promising delicious burgers, steaks and even sushi that is grown from animal cells in the lab.

But most cellular agriculture still looks like mush. The manufacturing process which starts with animal muscle and fat grown from stem cells in petri dishes is fine for making burgers, but it fails to provide the kind of texture needed for more substantial cuts of meat, like steaks.

Sharing the full story, not just the headlines

But scientists at Harvard University are reporting in a new study that they have found how to more closely mimic the form and flavour of real meat, by growing the muscle cells of cows and rabbits on a gelatine scaffold. Their research was published in the journal Science of Food.

To mimic this cellular environment, Kevin Kit Parker, a bioengineer at Harvard, and his colleagues decided to make scaffolds out of different concentrations of gelatine, a protein product derived from collagen. When collagen-rich meat cuts, such as beef chuck, are cooked, the heat naturally melts collagen fibres into softer gelatine, giving meat its succulent texture, Parker says.

To make gelatine microfibres, the researchers dissolved commercially available gelatine powder in water and spun it like cotton candy. Rotating the gelatinous slurry at high speeds allowed fibres to form at the bottom of the spinner. Using enzymes, the researchers then cross-linked the fibres to form a strong, woven structure for cells to grow on.

Rabbit and cow cells latched onto the gelatine scaffold, growing until they formed about a square inch of muscle.

To test whether the final product resembled the texture and behaviour of meat that chefs and home cooks use every day, the researchers performed a variety of food industry analyses: simulating cooking by heating the lab-grown meat on a hot plate, compressing it as if with a meat mallet and measuring the force needed to cut each piece of meat. They found that their lab-grown meat fell in between the springiness of a hamburger and a beef tenderloin.

Katsura leaves have a brown sugar scent (Getty/iStock)

Ahautumn, time to sniff that pumpkin spice and katsura?

Sugar, red and Japanese maples: you can drive up and down the East Coast of the US to enjoy their fiery pyrotechnic shows each fall. Along the way, you may want to stop, take a deep breath and try to catch a whiff of the katsura trees sweet scent.

Autumn seems to belong to pumpkin spice, and odours are often overlooked when it comes to fall foliage. We rave about how leaves die colourful deaths and rarely discuss how their scent changes with old age. But right about now, the leaves of the katsura, found all over New York City and in many other parts of the United States, are just beginning to turn.

Autumns earthy scent is the work of fungi and bacteria that decompose plant matter in the soil. But a chemical reaction in katsura leaves conjures fall spice, caramel and burntsugar. As the leaves ignite, changing from plum purple or green to yellow, they abandon the hay-like smell of leftover chlorophyll and adopt a scent more appropriate for a bakery.

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A team led by Ralf Berger, a flavour researcher in Germany, collected and analysed leaves from katsura trees throughout the year, and found maltol, a chemical compound used in flavour enhancers, perfume and incense.

Scientists have discovered crabs have a better memory than previously thought (Swansea University)

Its right turns only for some crabs in laboratory maze

Shore crabs can learn to navigate a lab-rat-style maze and remember it weeks later, according to a new study. While crabs that have never seen the maze before bump around aimlessly, experienced crabs race to the finish line with no wrong turns. The study, one of the few to look at whether crustaceans can perform such feats, suggests that crabs are quite capable of remembering routes.

Maze running could also be a way to measure the effects of changes in the sea, such as ocean acidification and warming, on crabs cognitive abilities.

The draw of nectar helped butterflies evolve (Getty)

How the butterfly discovered daylight

Once upon a time, perhaps some 300 million years ago, a tiny stream-dwelling insect akin to a caddis fly crawled from the water and began to live on mosses and other land plants. The creature would become the ancestor of the 160,000 species of moths and butterflies that populate Earth today.

A new study explains why nocturnal moths evolved into daytime butterflies. It wasnt to avoid darkness-loving bats, as biologists once thought, but to enjoy an abundant new drink: the nectar of flowering plants.

The researchers reconstructed the ancient timeline using DNA sequences of contemporary moths and butterflies. They calculated that the ancestral moth emerged some 300 million years ago, at the end of the Carboniferous era, well before the oldest known moth fossil, which is only 200 million years old.

The bellbirds song rivals the loudness of a pile driver (AFP/Getty)

He sings very loudly, just not very well

The pressures of sexual selection have made peacocks gorgeous, wood thrushes sonorous and birds of paradise great dancers. The white bellbird has a different quality.

This goofball boasts the loudest birdsong ever recorded, according to a new paper. And he sings the most piercing note right into potential mates faces.

The white bellbird is a favourite among birders in Brazil. When several sing at once, they are deafening, and sound like several blacksmiths trying to compete, says Arthur Gomes, a student who contributed to the research. Until a few years ago, assessing the amplitude, or loudness, of birdsong required an unusual amount of devotion and tech-savvy. But new tools are making the pursuit much easier.

New York Times

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VetStem Biopharma Shares the Success Story of Ole who was Treated with VetStem Cell Therapy by Dr. Holly Mullen – PR Web

November 5th, 2019 2:47 pm

His quality of life was significantly improved and Oles owner noted that VetStem Cell Therapy exceeded her expectations.

POWAY, Calif. (PRWEB) November 05, 2019

Ole, a German Shepherd, was demonstrating signs of osteoarthritis in April 2019. He was lame and stiff and had difficulty with stairs and jumping. Though his energy level and his willingness to play were normal, it was clear that he was in pain.

Oles owner took him to veterinary surgeon Dr. Holly Mullen of VCA Emergency Animal Hospital and Referral Center in San Diego, California. Dr. Mullen is an experienced VetStem user and has provided VetStem Cell Therapy services for over sixty patients. Upon examination, Dr. Mullen diagnosed Ole with severe osteoarthritis in his hips as a result of hip dysplasia. In patients with joint dysplasia, the affected joint is malformed causing the bone to rub irregularly, which can eventually lead to osteoarthritis. Ole was also diagnosed with osteoarthritis in his lower, or lumbar, spine. It was apparent that these issues were causing Ole discomfort.

In an effort to provide relief, Dr. Mullen recommended Ole receive VetStem Cell Therapy. Adipose-, or fat-derived, stem cell therapy is used by veterinarians to treat osteoarthritis and soft tissue injuries. VetStem Cell Therapy utilizes a patients natural healing cells which may reduce inflammation, block pain, and regenerate damaged joint tissues.

To begin the process, Dr. Mullen extracted fat from Oles abdomen in a minimally invasive anesthetic procedure. The fat was delivered to the VetStem laboratory in Poway, California where it was received and aseptically processed by trained VetStem laboratory technicians. Oles stem cells were extracted and concentrated from his fat tissue and dosed out into an injection that was delivered back to Dr. Mullen. Within 48 hours of the initial fat collection, Ole received one intravenous injection of his own stem cells.

As a follow up to his first injection, Ole received additional stem cell injections approximately two months later. This time he received one injection into each hip, injections along the muscles in his back, as well as an intravenous injection.

In a 90-day post stem cell therapy evaluation (approximately 90 days after the first treatment), Oles owner reported that he was no longer stiff or painful. She also noticed an improvement in his ability to go up and down the stairs, walk, and jump. His quality of life was significantly improved and Oles owner noted that VetStem Cell Therapy exceeded her expectations.

Dr. Mullens findings were similar at the 90-day examination. She stated, He is doing great! He runs around [the owners] acreage every day with no overt lameness and no signs of painhes strongly ambulatory with a bouncy gait.

Like Ole, many dogs suffer from osteoarthritis and unfortunately, treatment options are somewhat limited. For these patients, VetStem Cell Therapy may be an option. According to owners and veterinarians, greater than 80% of dogs showed an improved quality of life after receiving VetStem Cell Therapy for orthopedic conditions. Stem cells are regenerative cells that can differentiate into many tissue types, reduce pain and inflammation, help to restore range of motion, and stimulate regeneration of tendon, ligament and joint tissues. In a peer-reviewed study of dogs with chronic osteoarthritis of the hip, it was found that stem cells reduced lameness and pain.

About Holly Mullen, DVM, DACVSDr. Mullen received her DVM from Virginia-Maryland Regional College of Veterinary Medicine in 1985. She completed a small animal medicine and surgery internship as well as a residency in small animal surgery at the Animal Medical Center in New York City. In 1990, she became a board-certified veterinary surgeon. Dr. Mullen has been providing VetStem Cell Therapy for over a decade.

About VetStem Biopharma, Inc.VetStem Biopharma is a veterinarian-led Company that was formed in 2002 to bring regenerative medicine to the profession. This privately held biopharmaceutical enterprise, based near San Diego, California, currently offers veterinarians an autologous stem cell processing service (from patients own fat tissue) among other regenerative modalities. With a unique expertise acquired over the past 15 years and 17,000 treatments by veterinarians for joint, tendon or ligament issues, VetStem has made regenerative medicine applications a therapeutic reality. The VetStem team is focused on developing new clinically practical and affordable veterinary solutions that leverage the natural restorative abilities present in all living creatures. In addition to its own portfolio of patents, VetStem holds exclusive global veterinary licenses to a large portfolio of issued patents in the field of regenerative medicine.

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How Stem Cells Can Heal The Body – Version Weekly

November 5th, 2019 2:47 pm

Stem cells from the patients body when isolated and administered at an appropriate time and at the right place, with the right dose, is expected to help the patient in various ways

Stem Cells In The Body

All humans are born and develop from a small tiny structure called an egg. The cells in the egg have a tremendous potential to develop, multiply and form different cells that are functional in the body. These cells are called mother cells or in scientific terms, they are called stem cells. And all human beings have these stem cells preserved in the body. It is these cells that help us in every day wear and tear and also for tissue repair.

The Body Can Heal Itself

Most of the cells in our body have a definite lifespan that need to be replaced by new cells. The stem cell reserves in the body make up for this and it is done without our knowledge! In fact, any cut or injury, external or internal is healed by the bodys innate mechanism. Our intelligent body recognises the signal of injury and recruits the required stem cells. These stem cells transform themselves into the cells that are required for the repair of the injury and it is always many types of cells in various permutations and combinations.

Where Stem Cells Reside

Bone marrow can be considered as the manufacturing unit of stem cells as it is continuously making blood cells and keeps our circulatory system working perfect all the time. Circulating blood is another source of stem cells, because it works as a courier, carrying cells and other essential enzymes, hormones from one organ to the other in the body. The body converts all the extra material into fat which gets accumulated around the belly. This fatty tissue works like a fixed deposit of stem cells.

Stem cells either from the donor (allogenic) or from the patient (autologous) are being used for more than 50 years and especially for treatment. Blood cancers and other blood-related diseases can be cured using a perfect matched donor stem cells obtained from bone marrow. Patients suffering from organ cancers like breast cancer etc. are given autologous stem cells as a supportive treatment along with chemotherapy and/or radiation.

Protocols for these treatments are standardised globally and considered as standard-of-care. In recent years, umbilical cord blood derived stem cells are being used as an alternative to bone marrow, especially in the paediatric age group. People fall victim to numerous degenerative diseases which occur, as the repairing stem cell system from the body fails slowly with age. Stem cells from the patients body when isolated and administered at an appropriate time and at the right place, with the right dose, is expected to help the patient in various ways. It may also replace, rejuvenate or restore the damaged tissues.

Our body carnes its own repairing kit in the form of stem cells and the body tries its level best to make use of these stem cells to ward off diseases. However, it is possible that with age, the bodys power to recruit and make use of the stem cells diminishes slowly. This is when dreadful degenerative diseases like diabetes, arthritis, Parkinsons disease and heart problems, set in. Heres what the clinical applications of regenerative medicine have found novel mechanisms of:

It is increasingly observed that this kind of autologous therapy takes care of the root cause of disease and offers benefits to patients to whom there is no further solution in other modalities of treatment.

Since each tissue and organ of our body is made up of cells that are derived from the egg cell, any disease which is due to derangement or degeneration of cells can be cured using autologous cellular therapy. And though the list can be endless, here are some examples where there have been very promising results:

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UM Today the Magazine | Fall 2019 | After the Fire – UM Today

November 5th, 2019 2:47 pm

Twenty seconds. Give or take.

Spencer Beach cant say for sure just how long he was on fire.

Long enough to stumble to two exitstwiceand yank on door handles that wouldnt budge.

The flash fire that engulfed him in an Edmonton home was sucking in all the oxygen, creating a vacuum that sealed him inside. A flooring installer by trade, he had been removing linoleum in the laundry rooma rush job since the manufacturer mislabelled the boxes and the contractor didnt want to incur penalties for a delay. Beach and the rest of the crew were often told to use their boss homemade shortcut: douse the flooring in a contact thinner to reactivate the glue. That way, you could just peel it off.

He was on his hands and knees when he first heard a whistle as loud as a thousand kettles, followed by a boom as the furnace set the fumes alight.

Now the skin on his face felt like it was shrinking. His lips, like theyd been swarmed by bees.

The heat was inside of me. It wasnt like any burn youve ever felt, Beach says. It was everywhere.

With no way out, he curled up on the floor, interlocking his fingers behind his head. His mind flashed to his wife, Tina, blonde and four months pregnant with their first child. He had just left her a voice message: the job was nearly done, he was the only one left, hed be home soon. Tonight, hed plan his buddys stag party.

Beach got to his feet and tried the door one more time.

In his right hand, Dr. Sarvesh Logsetty holds a pair of scissors. In his left, a piece of paper grabbed from the many stacks in his office at Winnipegs Health Sciences Centre (HSC), where he is head of the burn unit.

The surgeon is stumped.

Hes trying to remember the strategic cuts to make for a trick he would do as a kid. Its a paper craft that turns a 4-by-5-inch sheet into an open shape large enough to walk through.

What am I doing wrong?

Logsetty wants to use the analogy to explain the skin graft meshing techniques he routinely does for patients whove suffered severe burns to large swaths of their body. The techniques also use strategic cutsto expand pieces of skin up to nine times their original size.

Every centimetre counts in these life-saving reconstructive surgeries where patches of unharmed skin are removed from one site to cover another, explains the University of Manitoba professor of surgery and psychiatry.

Ta da, he says, holding up the large paper circle. Damn, that was driving me insane.

Dr. Sarvesh Logsetty's curiosity about suturing goes back to age four, to Hyderabad, India, where he would hang around the medical clinic run by his great-aunt // PHOTO BY DAVID LIPNOWSKI [BA(HONS)/08]

Finding solutions is what the 51-year-old has spent decades doing, to alleviate pain and hardship for burn patients. Each one of my research projects, he says, reflects a patients journey.

Logsetty knows Beachs well, having operated on him more than a dozen times. He was working the day Beach was rushed to University of Alberta Hospital. The surgeon remembers how this 29-year-oldwith burns to more than 90 per cent of his bodywas more worried about how others would handle the news than he was his own chances for survival (about five per cent).

Even afterwards, hes always thought about how he can help other people and how he can use his experience to help them get through, says Logsetty, who brought his expertise to UM in 2007.

One persons recovery involves a slew of professionals.

Beyond nurses to do dressing changes, there are dietitians, physiotherapists, occupational therapists, psychologists, psychiatrists and social workers. On the burn ward at HSC, the team includes UM students across disciplines. The unit admits 100 to 200 patients a year, and treats another 250 to 400 (including cases of frostbite and flesh-eating disease). About 40 per cent of patients are children. Among the adults, the majority are men, who tend to engage in riskier behaviour than women, Logsetty notes.

When compared to other health conditions, theres an added layer. With any burn, theres a sense of guilt. Did I do something that caused this? Especially as a parent. That adds to the burden, says Logsetty. Its different than something spontaneous like cancer, where it isnt that they left the oil on the stove for too long or didnt check the temperature when they put their child in the bathtub.

With any burn, theres a sense of guilt. Did I do something that caused this? Especially as a parent. That adds to the burden. SARVESH LOGSETTY

Among 20- to 60-year-olds, burns are most often flame-related mishaps involving cooking oils catching fire, accelerants flashing back while burning grass, or house fires erupting in the night, Logsetty says. Burns from scalding are most common in kids and the elderly.

His research probes what social determinants increase your chances. A study released with UM psychiatrist Dr. Jitender Sareen [MD/95, BSc(Med)/95] last year showed people with a low income were as much as five times more likely to suffer burns. And the researchers mapped high-incidence areas in Winnipeg for policymakers to target prevention strategies.

Logsetty offers a window into the daily challenges on the burn unit. Within its dual-chamber isolation rooms, theres an ongoing battle against infection, down to the microscopic fibres of hospital curtains that may harbour antibiotic-resistant bacteria.

Burn patients face a far greater risk because their injuries arent straightforward open wounds. Theres dead skin sitting there, providing a perfect food source for bacteria. And because the skin is dead, theres no link to the bodys blood. No trigger to get infection-fighting white blood cells to activate and defend. So the bacteria can happily grow, getting stronger, says Logsetty. The risk of infection is really high.

The seeping wounds are kept covered and clean. Peeling off the dressings can be excruciatingly painful and take hours. No matter what we use, the dressings tend to stick, says Logsetty. This agony is what drives him and UM collaborator Song Liu, a medical microbiology and infectious diseases researcher, also in the Rady Faculty of Health Sciences, in their efforts to reinvent the burn bandage.

Together, theyre developing not only a less sticky coating but a dressing they hope will transform burn care. Theyre designing a fabric to detect infection, alert medical staff by changing colour, and then release antibiotics from withinall without having to remove it, Logsetty says.

Different colours would indicate different bugs. If the spot of colour were to grow bigger, it would tell nurses the infection wasnt getting any better. The bandage will be made of nanofibres, or straw-like chemical structures that break down when they come into contact with bacterial enzymes. The centres will be filled with either a liquid to release dye or a liquid containing the antibiotic. A bandage that both diagnoses and treats infection would be a first in the field. Logsetty says they could have a tangible product in as little as five years.

Liu also holds a patent for an antibiotic-resistant fabric, which could one day mean self-cleaning hospital curtains. He bonded a chlorine-like chemical to the curtain that kills bacteria on contact, one that not only wont wash out in the laundry but is reactivated by water. One of Logsettys recent studies showed that, within two weeks of being washed, five out of eight untreated hospital curtains tested positive for antibiotic-resistant MRSA.

PHOTOS BY AMBER BRACKEN

Leather hiking boots. Leather knee pads. A leather work belt. Beach didnt think twice about the gear he put on the morning of Aug. 24, 2003. (But he did contemplate calling in sickjust a feeling that he should, but one he ignored.)

The leather is what saved the less than 10 per cent of Beachs body surface that wasnt burned. His feet below the ankles. A patch in the middle of each knee. His waistline.

Theres a line around my waist where you could see where my belt was, he says.

Only once the vapours and air pressure subsided in the home was he able to open the door to the garage and escape. A neighbour then came running with a hose.

Since that day, Beach has undergone 38 surgeries.

His burns reveal the most severe form: third- and fourth-degree, which tear through the epidermis and dermis and extend into the muscle, fat and bones. At first, these sites (that appear white or charred-black) are the least painful for patients, since the flames have destroyed the nerve endings.

While lesser burns can heal on their ownas cells lining our sweat ducts and hair follicles automatically spread out to rebuildsevere burns require grafting.

Skin from Beachs feet is now on his face. As is skin from his knees and hip. Pieces of his foreskin form his delicate, upper eyelids while skin from his scrotum shapes his lower.

Logsetty can use meshing instruments that stretch and expand what small percentage of skin survivesthe graphs look like criss-crossed grids, almost translucentbut each time he does, the skin gets thinner, leaving more room for scar tissue to fill in the gaps. Its the scarring that leads to chronic pain.

[With Beach] I had to take three per cent and expand it into more than 90 per cent, somehow or another, says Logsetty. The key to advancing burn care, he says, is to develop ways to grow better skin.

[With Beach] I had to take three per cent and expand it into more than 90 per cent, somehow or another. SARVESH LOGSETTY

Beach received synthetic skin, as well as skin from cadavers, before new skin was cultured from his own cells. With Logsetty at the helm, Beach became the firstand is still the onlyCanadian to receive a unique, double-layer skin thats more resilient than anything thats come before. A sample of his skin, the size of a business card, was cultured in a lab in Cincinnati, OH, and then multiplied time and time again to eventually cover nearly half his body.

Experimental in the early 2000s, the technique is still innovative today, says Logsetty, but not yet widely available because the company has faced hurdles bringing it to market. From an overall standards of burn care, its a gamechanger, he says.

Even though there are still improvements to makethe skin doesnt contain pigment, hair follicles or sweat ducts (so on a hot summer day, Beach has to watch for heat stroke)it means less scarring and greater quality of life, says Logsetty.

Hes also in the process of developing a research project at UM that will explore new ways to use stem cells to create skin, and is collaborating with a Quebec company, Loex, on a similarly robust skin alternative.

Skin-grafting surgeries can be marathons of endurance and difficulty. An intensive operation can take 12 hours, but shorter is best since patients are already so unstable going in. The temperature of the room is kept at 29.9C to prevent patients from becoming hypothermic. Their whole body is exposed on the tablein order to graft different areasand without skin, theyre without a key organ that helps regulate body temperature. When our temperature drops, we bleed more, so theres also a greater risk of bleeding out on the table. Disposable warming blankets, inflated with warm air, help retain heat.

In the stifling environment, Logsetty and the team wear surgical gowns made of Gortex or other waterproof fabrics. (One of his research projects studies the effects on the medical team, including how much weight they lose from sweat during a procedure.)

On this ward, named after Manitoba firefighters, the mortality rate is less than three per cent, on par with the top burn centres across North America, notes Logsetty. Not many of their patients are firefighters nowadays, given how safety training and gear have evolved. But unfortunately, when they do become injured, he says, its usually devastating.

Nine months after the fire, Beach rolled over for the first time. He had lost 63 pounds and at six-foot-two was down to 112. The scar tissue had built up on his ligaments and tendons, and his muscles were wasting away with atrophy. The movement was small but it felt like a big win that came just in time. After the fire, he was angry, depressed, suicidal; now he wanted to see what else he could do for himself.

With progress comes greater survival rates, which mean more people living with the long-term consequences of burn injuries like disability, financial problems and chronic pain. Trauma survivors are at least four times more likely to take their own life, Logsetty and Sareen revealed in a 2014 study. Theyve since discovered theyre also twice as likely to have depression, anxiety or substance-abuse issues.

The standard of care I try to hold myself toand teach my studentsis What would you expect for you or your loved one? SARVESH LOGSETTY

Logsetty says patients often tell him they dont want to go on. He helps them reintegrate with the life they once had, as much as possible. Its not, I fixed your hernia, your sutures are out, you can call me if you have a problem. There is a continuity of care we dont see in most other surgery.

Thats why hes made this his lifes work. One patient describes Logsetty as the most caring and considerate doctor I have ever met; another says he created a place of love in the burn unit.

The only burn expert between Edmonton and Toronto, he makes himself available 24-7 to residents and nurses, even when not officially on call. The standard of care I try to hold myself toand teach my studentsis What would you expect for you or your loved one? says the father of two kids (under age seven), and husband to epidemiologist Rae Spiwak [BA(Adv)/00, MSc/04, PhD/17], who also studies mental-health issues in trauma patients. The biggest thing Ive learned is that life can change in an instant.

This summer, Logsetty spoke at Winnipegs inaugural Face Equality Awareness event for people living with facial differences. Its important, he adds, to help people understand that, although the outside of somebody might have changed, the inside is still the samepart of what our team does really well is help burn survivors come to that understanding themselves.

It was Beachs wife who held up the mirror for him the first time, only once hed consulted with a psychologist. He couldnt bring himself to look beyond his nose, with its missing lobes and exposed bridge. Gone was the dimpled grin of a guy who was always the life of the party.

Now, if kids stare at the grocery store, hell engage with a smile and a wave. Often, they think hes just really olda grandpa, not a father, to his kids, he says. When adults approach, which hes totally fine with, its always the same question: Can I ask what happened?

Beach doesnt have photos of what he used to look like up in his house, only because theyre not picture people. And no longer does he appear as his former self in his dreams.

Im extremely proud of who I am, Beach says.

Hes a motivational speaker who finds fulfillment in trying to create positive change in the workplacewhos spoken to Winnipeg workers about putting safety before money and supervisors demands. But his life isnt without ongoing challenges.

He has nerve damage and reduced mobility in his joints.

(He says he has the equivalent of seven-and-a-half fingers, since doctors had to amputate portions, up until they found blood flow.) And with some stubborn wounds that wont heal, he regularly gets blood infections20 in the last 10 years. Nonetheless, he renovated his basement and next, hell build a fence.

Im extremely proud of who I am. SPENCER BEACH

With burn survivors like Beach, Logsetty notes, The scar doesnt define them. They define themselves.

In a recent Facebook post, he signed off one tough son-of-a Beach.

You want to be the person you used to be, Beach says, but now you have a different body to do it with.

He returnedjust onceto the site where it happened. Where a new house now stands.

I had to see it.

Early in his career Dr. Sarvesh Logsetty saw how each burn unit across the country was labouring in its own bubble. We have some very good burn centres across Canadapeople are doing great work and researchbut we didnt really work together as a burn program in Canada as a community.

When he joined UM in 2007 he established the Advancement of Burn Care Network and made Winnipeg its base. And last year he launched the Canadian Burn Association and annual symposium further connecting the multidisciplinary players in burn care including firefighters and survivors to learn whats working whats not and what to try next.

He says research in burn treatments is grossly underfunded since there are fewer champions for the cause. Were still at the infancy of really understanding wound healing says Logsetty how to improve it how to avoid scars where we can and how we can make them better.

While the frequency of burns has dropped dramatically since the 1960swith greater safety awareness smoke detectors and legislation to safeguard water heaterstrauma as a whole is still the leading cause of death in Canadians 40 and under. It costs the system more money than just about any other health-care problem thats out there, yet we barely hear about traumatic injury says Logsetty who as a general surgeon is also tasked with removing knives from abdomens after weekend violence, or bowels burst in car collisions. In the last week alone hes removed two spleens ruptured in crashes.

What frustrates me from an academic perspective is that trauma doesnt have a home. There is no institute for traumait gets lumped in under muscoskeletal health and arthritis. That means, in terms of resources, were struggling with identification of the importance of trauma and struggling with helping people understand why we do the research we do and how it affects the people that it affects.

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UM Today the Magazine | Fall 2019 | After the Fire - UM Today

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International Conference on Stem Cells and Regenerative Medicine – Hoover Sun

November 5th, 2019 2:45 pm

Join us! To furnish your research and ideas and to examine your interpretation at International Conference on Stem Cells and Regenerative Medicine which is scheduled on November 06 - 07, 2019 at Tokyo, Japan.

Stem Cells 2019 provides you with a unique platform to share your generous thoughts and ideas related to your research and it adds a valuable acknowledgment to your profile.

The conference is based on the theme of Novel Techniques in Stem Cells and Regenerative Medicine. Based on this, we are delighted to have your presence at our conference.

Highlights include: Stem Cells, Regenerative Medicine, Tissue Regeneration, Therapeutic Cloning, and Stem Cell Transplantation which is detailed in Stem cells

To Visit our conference webpage: http://stemcells.pulsusconference.com/

Hope you will join hands with us to encourage Stem Cells research to have a better tomorrow.

We look forward to receiving a favorable consideration from you.

Explore the evidence to make a difference!

Best Regards,

Veronica Carter

Program Manager | Stem Cells 2019

E: stemcellresearch(at)pulsusglobalevents(dot)com

Ph: 44-203-769-1778

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International Conference on Stem Cells and Regenerative Medicine - Hoover Sun

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The Alliance for Regenerative Medicine Releases Q3 2019 Sector Report, Highlighting Industry Trends and Metrics – BioSpace

November 5th, 2019 2:45 pm

WASHINGTON, D.C., Nov. 05, 2019 (GLOBE NEWSWIRE) -- via NEWMEDIAWIRE -- The Alliance for Regenerative Medicine (ARM) today released its most recent quarterly sector report, offering an in-depth look at cell therapy, gene therapy, tissue engineering, and broader global regenerative medicine sector trends and metrics in the third quarter of 2019.

By further curating information provided by ARMs data partner Informa, the quarterly sector report details industry-specific statistics compiled from 959 cell therapy, gene therapy, tissue engineering, and other regenerative medicine therapeutic developers worldwide, including total financings, partnerships and other deals, clinical trial information, key clinical data events, and ARMs current strategic priorities.

Amanda Micklus, a senior consultant for Pharma Intelligence at Informa, provided an overview of the commercial, clinical, and regulatory environment in the third quarter of 2019. The report also features commentary from founding members of ARM in honor of the organizations 10-year anniversary. Excerpts from panels at ARMs 2019 Meeting on the Mesa included in the report highlight the continued progress and innovation in the sector.

Highlighted findings from the Q3 2019 data report include:

ARM will continue to update this information through new reports to be released after the close of each quarter, tracking sector performance, key financial information, clinical trials by phase, and significant clinical data events.

The report isavailable online here, with interactive data and downloadable graphics from the reportavailable here. For more information, please visitwww.alliancerm.orgor contact Lyndsey Scull at lscull@alliancerm.org.

About the Alliance for Regenerative Medicine

The Alliance for Regenerative Medicine (ARM) is an international multi-stakeholder advocacy organization that promotes legislative, regulatory and reimbursement initiatives necessary to facilitate access to life-giving advances in regenerative medicine worldwide. ARM also works to increase public understanding of the field and its potential to transform human healthcare, providing business development and investor outreach services to support the growth of its member companies and research organizations. Prior to the formation of ARM in 2009, there was no advocacy organization operating in Washington, D.C. to specifically represent the interests of the companies, research institutions, investors and patient groups that comprise the entire regenerative medicine community. Today, ARM has more than 350 members and is the leading global advocacy organization in this field. To learn more about ARM or to become a member, visithttp://www.alliancerm.org.

Lyndsey Scull202 213 7086lscull@alliancerm.org

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The Alliance for Regenerative Medicine Releases Q3 2019 Sector Report, Highlighting Industry Trends and Metrics - BioSpace

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