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What is Biotechnology: Types, Examples and Applications …

May 2nd, 2019 6:49 am

Biotechnology is the use of biological systems found in organisms or the use of the living organisms themselves to make technological advances and adapt those technologies to various different fields. These include applications in various fields from agricultural practice to the medical sector. It does not only include applications in fields that involve the living, but any other field where the information obtained from the biological aspect of an organism can be applied.

Biotechnology is particularly vital when it comes to the development of miniscule and chemical tools as many on the tools biotechnology uses exist at the cellular level. In a bid to understand more regarding biotechnology, here are its types, examples and its applications.

According to Biotechnology Innovation Organization,

Biotechnology is technology based on biology biotechnology harnesses cellular and biomolecular processes to develop technologies and products that help improve our lives and the health of our planet. We have used the biological processes of microorganisms for more than 6,000 years to make useful food products, such as bread and cheese, and to preserve dairy products.

Medical biotechnology is the use of living cells and other cell materials for the purpose of bettering the health of humans. Essentially, it is used for finding cures as well as getting rid of and preventing diseases. The science involved includes the use of these tools for the purpose of research to find different or more efficient ways of maintaining human health, understanding pathogen, and understanding the human cell biology.

Here, the technique is used to produce pharmaceutical drugs as well as other chemicals to combat diseases. It involves the study of bacteria, plant and animal cells to first understand the way they function at a fundamental level.

It heavily involves the study of DNA (Deoxyribonucleic acid) to get to know how to manipulate the genetic makeup of cells to increase the production of beneficial characteristics that humans might find useful such as the production of insulin. The field usually leads to the development of new drugs and treatments, novel to the field.

Vaccines are chemicals that stimulate the bodys immune system to better fight pathogens when they attack the body. They achieve this by inserting attenuated (weakened) versions of the disease into the bodys bloodstream. This causes the body to react as if it was under attack from the non-attenuated version of the disease. The body combats the weakened pathogens and through the process takes note of the cell structure of the pathogens and has some cell remember the disease and store away the information within the body.

When the individual becomes exposed to the actual disease, the body of the individual immediately recognizes it and quickly forms a defense against it since it already has some information on it. This translates to quicker healing and less time being symptomatic.

The attenuated disease pathogens are extracted using biotechnological techniques such as growing the antigenic proteins in genetically engineered crops. An example is the development of an anti-lymphoma vaccine using genetically engineered tobacco plants made to exhibit RNA (A similar chemical to DNA) from malignant (actively cancerous) B-cells.

Strides have been made in the development of antibiotics that combat pathogens for humans. Many plants are grown and genetically engineered to produce the antibodies. The method is more cost effective than using cells or extracting these antibodies from animals as the plants can produce these antibodies in larger quantities.

Agricultural biotechnology focuses on developing genetically modified plants for the purpose of increasing crop yields or introducing characteristics to those plants that provide them with an advantage growing in regions that place some kind of stress factor on the plant namely weather and pests.

In some of the cases, the practice involves scientists identifying a characteristic, finding the gene that causes it, and then putting that gene within another plant so that it gains that desirable characteristic, making it more durable or having it produce larger yields than it previously did.

Biotechnology has provided techniques for the creation of crops that express anti pest characteristics naturally, making them very resistant to pests, as opposed to having to keep dusting them and spraying them with pesticides. An example of this would be the fungus Bacillus thuringiensis genes being transferred to crops.

The reason for this is that the fungus produces a protein (Bt) which is very effective against pests such as the European corn borer. The Bt protein is the desired characteristic scientist would like the plants to have and for this reason, they identified the gene causing Bt protein to express in the fungus and transferred it to corn. The corn then produces the protein toxin naturally, lowering the cost of production by eliminating the cost of dusting the crop with pesticide.

Selective breeding has been a practice humans have engaged in since farming began. The practice involves choosing the animals with the most desirable characteristics to breed with each other so that the resulting offspring would also express these traits. Desirable characteristics included larger animals, animals more resistant to disease and more domicile animals, all geared to making the process of farming as profitable as possible.

This practice has been transferred to the molecular level with the same purpose. Different traits are selected among the animals and once the genetic markers have been pointed out, animals and plants with those traits are selected and bred for those traits to be transferred. A genomic understanding of those traits is what informs the decisions on whether the desired traits will express or get lost as recessive traits which do not express.

This information provides the basis for making informed decisions enhancing the capability of the scientists to predict the expression of those genes. An example is its use in flower production where traits such as color and smell potency are enhanced.

One of the biggest uses of biotechnology is the infusion of nutrients into food in situations such as aid. Therefore, it provides food with heavy nutrients that are necessary in such situations. An example of this application is the production Golden Rice where the rice is infused with beta-carotene. The rice has Vitamin A, which the body can easily synthesise.

There is actually very little land on earth that is arable with some estimates place it at around 20 percent. With an increase in the worlds population, there is a need for the food sources available to be as effective as possible to produce as much food in as little space as possible. There is also need to have the crops grown to be able to make use of the less arable regions of the world.

This means that there is a need to develop crops that can handle these abiotic stresses such as salinity, drought and frost from cold. In Africa and the Middle East, for instance, where the climate can be unforgiving, the practice has played a significant role in the development of crops that can withstand the prevailing harsh climates.

The industrial applications of biotechnology range from the production of cellular structures to the production of biological elements for numerous uses. Examples include the creation of new materials in the construction industry, and the manufacture of beer and wine, washing detergents, and personal care products.

One of the materials with the strongest tensile strength is spider webs. Amongst other materials with the same cross sectional width, spider webs can take more tensional force before breaking than even steel. This silk has created a lot of interest with the possible production of materials made from silk including body armour such as bullet proof jackets. Silk is used because it is stronger than Kevlar (the material most commonly used to make body armour).

Biotechnological techniques have been used to pick the genes found in spiders and their infusion in goats to produce the silk proteins in their milk. With this initiative, it make production easier as goats are much easier to handle compared to spiders and the production of silk via milk also help make the processing and handling much easier compared to handling the actual silk strands.

One of the biggest applications of biotechnology is in the energy production sector. With fears over the dwindling oil resources in the world and their related environmental impacts, there is a need to protect the globes future by finding alternative environmentally friendly fuel sources. Biotechnology is allowing this to happen with advances such as using corn to produce combustible fuel for running car engines. These fuels are good for the environment as they do not produce the greenhouse gases.

Biotechnology is applied in the healthcare sector is the development of pharmaceuticals that have proven problematic to produce though other conventional means because of purity concerns.

A true environmentalist by heart . Founded Conserve Energy Future with the sole motto of providing helpful information related to our rapidly depleting environment. Unless you strongly believe in Elon Musks idea of making Mars as another habitable planet, do remember that there really is no 'Planet B' in this whole universe.

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Stem Cell Treatment in India | Stem Cell Therapy in Uttar …

May 2nd, 2019 6:49 am

We have expanded an expertise & capacities in accumulating and separating stem cells from the available organic material Adipose Tissue, Umbilical Cord Blood & Tissue, Amniotic Fluid, Amniotic Sac, Dental Pulp, Bone Marrow and Menstrual Blood.

We truly believe that stem cells is the perfect future to prevent age related degeneration. A period will come when the bodys own particular cells will assist in restoring youth and staying healthy without any drugs.

As the main health care consultant, stem cell center takes care of all section of the medical Tourism to New Delhi. We guarantee our patients get the best health care services by bringing in place, the famous multi-specialty hospitals, recent stem cell treatments, economical accommodations and travel alternatives for the patients.

We are passionate about the recent developments in stem cell therapies in India and endeavor to deliver safe and viable treatment alternate to patients all over the world at the highest medical standards.

At stem cell center, we have a vigorous team of researchers and clinicians at the helm of fundamental research in stem cells. We trust in creating a network of researchers and experts who are bound by a common interest and add to each others comprehension of the subject.

Our Stem cell Treatment services for Degenerative diseases

Spinal Cord Injury

Non-union Fracture

Peripheral Arterial Disease

Optic Nerve Damage

Diabetes

Brain Stroke/Injury/Coma

Avascular Necrosis

Coronary Arterial Disease

Retinitis Pigmentosa

Acute/Chronic Kidney Disease

Cerebral Palsy/Atrophy

Rheumatoid Arthritis

Macular Degeneration

Myocardial Infarction (MI)

Autism

Knee Cartilage Damage

Muscular Dystrophy as DMD, LGMD & BMD

Parkinsons Disease

Lung Fibrosis or COPD

Alzheimer Disease

Diabetic Foot Ulcer & Gangrene

Motor Neuron Disease

Sports Injury Treatment

Multiple Sclerosis

Liver Cirrhosis

Our Vision

The vision of stem cell center is to be a pioneer in the zone of stem cell research, stem cell banking and development of numerous stem cell based procedures and products that will address the neglected medical requirement.

Our Mission

In accordance with the activities of the group in the area of hematology, pathology and transfusion drug, stem cell based medicine will be the following in the pipeline .The group has the mission to think with cell based procedures and results of highest quality for clinical utilize. The mission is to have an authorize facility that meets the directions of both Indian and global standards.

If you have any queries related to stem cell therapy then contact us without any hesitation on our contact numbers:-

Md. No:- +91-9650988899, 91-9891404143

To get quick response, fill our quick contact form

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Adult Stem Cell Therapy Is A Resounding Healing Success …

May 2nd, 2019 6:49 am

Adult stem cell therapy is enjoying widespread success around the world, but if the FDA gets its way, it may soon be banned here in the U.S....

There have been nearly 12,000 adult stem cell therapies performed in the United States with an over 90 percent success healing rate for mostly joint and spinal conditions. It involves using the patients own stem cells, so no patent-able drugs are involved.

They are targeting the most influential stem cell scientist in the U.S., Dr. Kristin Comella in Florida.

Differentiating the Types of Stem Cell Therapy

They could be considered seeds for growing body tissues. They are mostly able to function for cellular repair and growth no matter what organ is in need of repair or healing from chronic inflammation.

There is a considerable controversy surrounding stem cell therapy research, a branch of regenerative medicine. Much of the controversy has to do with not differentiating between adult stem cell therapy and embryonic stem cell therapy.

Read: Scientists Discover That Fasting Triggers Stem Cell Regeneration & Fights Cancer

Embryonic stem cell therapy is the controversial one. It cultures or creates stem cells from terminated or aborted fetuses.

Currently, the FDA is harassing stem cell clinics that do not derive their stem cell solutions from aborted fetus tissue. They extract the stem cells from the patients own adipose tissue and inject them into areas where that same patient needs repair. Its an autologous process called adult stem cell therapy.

U.S. Stem Cell based out of South Florida is one of the clinics being targeted by the FDA, and the clinics Chief Scientist is Dr. Kristin Comella, PhD.

Many other nations have been using adult stem cell therapy successfully over the past 15 years, leaving the USA dead last in this field. The FDA is trying to make sure it stays that way and allows costly pharmaceutical versions to prevail.

Dr. Kristin Comella and her clinic have been under attack from the FDA.

This short 3-minute video was produced interviewing Dr. Comella and some of her patients.

Examining and Comparing the Different Types of Stem Cell Therapy

Human embryonic stem cell (hESC) therapy has received most of the medias attention and government support. But it is the most controversial because it involves extracting tissues from terminated human embryos, aka aborted fetuses.

In addition to moral and ethical issues, human embryonic stem cell (hESC) solutions create cells so rapidly where theyre injected they lead to cancerous tumors. To avoid that, researchers have to use immuno-suppressant drugs to curb the embryonic stem cells tendency toward cancer.

Using pharmaceutical drugs to curb hESC cancer side effect issues leads to other unexplored and unexpected side effects from those patented stem cell solutions.

But the profit motive for embryonic stem cell therapies was strong and a lot of government funds had been put into its research. Pharmaceutical companies were motivated because they could patent stem cells created from embryonic tissues.

Bone marrow stem cell therapy was among the first to depart from flawed hESC (human embryonic stem cell) therapies developed over the past two decades. Bone marrow stem cell therapy was the segue into the adult stem cell therapy movement.

Bone marrow extractions are painful, requiring general anesthesia. Its relatively difficult and expensive compared to adipose (fat) tissue stem cell harvesting.

Bone marrows high white blood cell count also encourages inflammation, making it counter-productive for patients already suffering from chronic inflammation or autoimmune disorders.

Most importantly, adipose (fat) tissue yields up to 500 times more mesenchymal stem cells than bone marrow sources, according to Dr. Comella. These are potent stem cells that can differentiate into a wide variety of other cell types. Furthermore, the adipose white blood cell count is lower than bone marrow matter.

Overactive, confused immune responses attack organs continually and create chronic inflammation and autoimmune diseases. The lower white blood cell count automatically lowers the risk of further inflammation among patients already suffering from chronic inflammation and autoimmune diseases.

The outpatient treatment involves creating a very small and shallow incision that wont require stitches on an area of skin covering adipose tissue (fat). From there, liposuction can withdraw a portion of the fat. This part of the procedure requires only a local anesthetic.

Then what is extracted is spun at high speed in a special centrifuge to isolate the stem cells which are then purified for IV drip delivery or injection into the same patient from whom it was extracted. Total costs range from five to ten thousand dollars or more in some cases.

Dr. Comella and her colleagues mission is to get adult stem cell therapy available for everyone. Private and government health insurance providers cover medical treatments that are much more expensive.

Why not cover one that would save money with its lower expense and fewer side effects?

Over the years, there have been nearly 12,000 adult stem cell therapies performed in the United States with an over 90 percent success healing rate for mostly joint and spinal conditions as well as heart and lung issues.

But the three known adverse side effect cases continually get all the media attention.

The Panama College of Cell Science, which helped launch Kristin Comellas research and development, had this to say about her:

"Perhaps the most influential clinician on the subject of adult stem cell therapy, Dr. Comella has been able to quietly develop patient treatment protocols and treat patients via collaborating physicians and health care providers using legal patient-specific FDA guidelines, including studies permitted by Institutional Review Boards, patient-specific stem cell clinical trials, and direct treatments using the patients own stem cells that are harvested and re-injected for therapeutic purposes.

"Through Dr. Comellas leadership, she and her team have trained and certified more than 700 physicians worldwide in adult stem cell therapy." (Source)

The interview below allows the energetic Dr. Kristin Comella to give a thorough and upbeat description of adult stem cell therapy.

Big Pharma Is Using the FDA to Eliminate Unregulated Adult Stem Cell Competition

Since the late 1990s, adult stem cells used therapeutically were not under the control of the FDA and the adult stem cell movement took off.

There were complaints from some MDs that the adult stem cell practice should be regulated by the FDA. The Panama College of Cell Science responded to those outcries with this statement:

"The motive in opposing adult stem cell therapy is money. The big institutions want to keep federal funding of embryonic stem cell research at a high level with the promise that cures are just around the corner despite the fact that embryonic stem cells will never be useful in any way for patient treatment because they immediately cause tumors when transplanted." (Source)

Adult stem cell therapy is an autologous treatment method. The stem cells are not lab-created. They are only isolated and purified after extracting them from the patient being treated. Injecting them back into that patient powers up the bodys own healing mechanism to overcome chronic ailments.

The FDA didnt and shouldnt have anything to do with regulating stem cells from ones own body. That situation has recently been arbitrarily and suddenly changed.

Around 2014, the FDA started tweaking their guidance rules for stem cell therapy with the purpose of getting new rules made into laws through Congress that could be interpreted according to FDA whims and enforced arbitrarily. Their agenda is to consider adult stem cells as FDA-regulated drugs.

During our phone conversation, Dr. Comella explained how the FDA ignored testimonies from adult stem cell practitioners during their 2015 public hearings regarding new guideline proposals. Then they arranged to create new rules behind closed door meetings that included pharmaceutical industry allies and insiders.

The result was that by 2017, the FDAs hands-off policy with adult stem cell therapy came to a sudden halt after years of highly successful stem cell practice.

By 2018, the FDA got nastier with the the most influential clinician on the subject of adult stem cell therapy as its target. The FDA started doing inspections of Dr. Comellas South Florida clinic that are designed for labs that manufacture drugs.

The standards for hospitals and clinics are not as strict as drug manufacturers. Those inspections were inappropriate for a clinic. But those inspections made it easier to create damaging reports.

When the inspectors came by, they demanded to go into rooms while treatments were taking place with semi-nude or nude patients, which Dr. Comella prohibited. The inspectors also demanded to view patient medical records. She allowed that after redacting their names on the copies she gave them.

For her actions to protect patients privacy, inspectors allegedly cited Dr. Comella for resisting and obstructing FDA inspections.

Soon after the inspections, the FDA served Dr. Comella with a lawsuit for practicing medicine with unapproved drugs. The drugs were only those stem cell solutions drawn from patients to be used on them.

The FDA has allegedly offered to drop the lawsuit if Dr. Comella signed an agreement to stop doing adult stem cell therapy and no longer promote it.

She refused. She said she has witnessed people leave their wheelchairs for good from this therapy. The trial is set for a Federal Court hearing beginning June 2019, in Miami, Florida.

If Dr. Comella loses this court case, adult stem cell therapy in the USA may be forced out of the country and only be available to those who can afford medical tourism.

Reference: HealthImpactNews.com

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Animal Hospital Serving Mesa, AZ – 1st Pet Veterinary Centers

May 2nd, 2019 6:48 am

.col > .col-inner { padding: 0px 0px 0px 0px; } Entrust Your Pet to a Skilled Veterinarian in Mesa, AZ.

Your pet is part of your family. Whether you own a dog or a cat you want your pet to live free of disease and injury. When your pet needs preventative care or emergency services, you need to bring your beloved companion somewhere it can receive the treatment it needs.

Whether your pet needs preventative veterinary medicine or an after-hours exam by an emergency vet in Mesa, AZ, contact 1st Pet Veterinary Centers.

In 1989, 1st Pet began with the desire to bring first-class veterinary care to the Mesa area. As we grew, so did our ability to serve your pets. Like us, animals can receive a variety of primary care services, including vaccines, dental care, and cleaning. Other primary care services we offer include these:

In addition to these general pet care services, 1st Pet offers emergency aid for your injured or sick animals. Available 24-hours a day, 365 days a year, our team can handle all your pets veterinary needs. We work around the clock because emergencies do not usually happen at convenient times.Our veterinary specialists have training in critical care, internal medicine, and veterinary surgery. Our staff will also give your pets the same care they would give to their own pets.

When you need an animal hospital in Mesa, AZ, call us at (480) 924-1123 or visit us at 5404 E. Southern Ave. We offer compassionate veterinary services to help your pet return to full health.

5404 E. Southern Ave.Mesa, AZ 85206tel:(480) 924-1123

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Ethical, Legal and Social Implications Research Program …

April 30th, 2019 3:57 pm

NIH is institutinga number ofchanges tohow it categorizes clinical trial research.Many ELSI studiesthat previously were not considered clinical trials will now be categorized as such and will be subject to new application, review and reporting requirements.Please visit theClinical Trials definition websitefor guidance indetermininghow your study will be categorized. If you have any questions or concerns, please contact ourELSIprogram directors

ELSI applications that do not involve a clinical trial can still be submitted under the ELSI R01, R21 and R03 program announcements listed below.

ELSI applicationsthat are determined to involve a clinical trial cannot be submitted under these announcements and must now besubmitted under either the NIHParent R01--Clinical Trial Required(PA-18-345)or the NIHParent R21--Clinical Trial Required (PA-18-344)program announcements.When submitting these applications, researchers shoulduse thePHS Assignment Request Formtorequest thatNHGRI (and any other relevant Institutes or Centers) be assigned the grant, andtorequest study section review assignment to theContinuous Special Emphasis Panel on Societal and Ethical Issues in Research Study Section(ZRG1 SEIR).

The NHGRI, along with several other National Institutes of Health (NIH) institutes, has released revised general program announcements to solicit research projects that anticipate, analyze, and address the ethical, legal, and social implications of the discovery of new genetic technologies and the availability and use of genetic information resulting from human genetics and genomic research.

The NHGRI ELSI Program accepts Conference Grant (R13) applications. For specific instructions for preparing a conference grant application, see:

The ELSI program participates in a number of training and career development funding opportunities.

The Fogarty International Center'sinternational bioethics training programs[fic.nih.gov] support education and research training to develop ethics expertise in low- and middle-income countries (LMICs). The programs complement other global health research and research training programs in the mission areas of NIH Institutes and Centers.

PA-16-288:Research Supplements to Promote Diversity in Health-Related Research (Admin Supp)Expiration Date: September 30, 2019

PA-16-289:Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (Admin Supp)Expiration Date: September 30, 2019

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Russia Opens the Door for Stem Cell Clinical Trials | BioSpace

April 30th, 2019 3:56 pm

Stem Cell Global Boom

The widespread global outreach potential of stem cell therapies is becoming apparent, especially given the recent news of a second person going into long-term remission (some saying cured) of HIV after undergoing a stem cell transplant. Regenerative medicine is becoming a powerful instrument for providing cures to previously incurable diseases. According to a recent statement, the US FDA expects to receive over 200 investigational new drug (IND) applications per year by 2020, many of which include cell and gene therapies. In fact, the FDA estimates that 10 to 20 new cell and gene therapy products per year will be approved by 2025. The number of stem cell trials carried out globally has also been growing exponentially, having over 7000 trials registered on ClinicalTrials.gov with 16 FDA-approved cellular and gene therapies.

The Official Launch of Biomedical Cell Products (BCP) in Russia

While the US, Europe and some Asian countries have had a fully functional, comprehensive regulatory platform for BCP procedures for over two decades, Russia is relatively new to the area, only recently approving a regulatory framework. 2018 marked a key breakthrough for the Russian market and the global pharmaceutical arena, when the Russian government enacted a law involving amendments to biomedical cell product guidelines, which officially opened the door for Russia to enter the stem cell technologies industry. The regulation stipulates and defines what a BCP is, specifying that both registered medical products and pharmaceuticals can be classified as BCPs.

When speaking about the current pharma industry landscape, the major development of the past several years is, without doubt, the creation and implementation of stem cell product regulation and related clinical trial procedures," Dmitry Goryachev, head of Expertise and Control of Ready Medicaments at the FSBI Russian Ministry of Health Scientific Centre for Expert Evaluation of Medicinal Products, noted during the 6th annual OCT Conference on Clinical Trials.

Although cellular biomedicines show great promise, there are some important scientific and practical nuances to note, such as patent rights, certification procedures, and BCP costs. Experts from the I. M. Sechenov Institute for Regenerative Medicine claim that one of the key challenges for biomedical stem cell production in Russia lies in the absence of suitable production sites, with an estimated cost of building such infrastructure as high as USD 7 million.

Alexey Martynov, Director of the Stem Cell Products Manufacturer Association, added that with the stem cell industry on the rise, there is an exponentially growing demand for trained professionals in the field, therefore relevant courses are being included in the universities curriculum for students as well as professionals. There are also a few widescale government programs which stimulate the emergence of new medical products and innovative technology in healthcare. One such program is aimed at developing stem cell technologies.

The Russian Federation government has recently issued specific decrees which outline the stem cell technologies development strategy for 2018-2020. This program undertakes the development of knowledge sharing centers, both from the product development and production points of view, as well as medical center accreditations for them to be eligible for such studies, Vadim Merkulov, Deputy Director of the Russian Ministry of Health Scientific Centre for Expert Evaluation of Medicinal Products, elaborated.

According to the previously mentioned BCP procedure law, the number of accredited entities eligible to accommodate stem cell clinical trials will grow from 5 in 2018 to 20 in 2019 then up to 50 in 2020. The budget for BCP production, called production capacity, is also estimated to reach USD 230 million by 2020, up from USD 180 million in 2018. This strategy will stimulate and potentially boost stem cell studies in Russia, ultimately resulting in increased patient access to stem cell therapies.

Russian Market Potential for Stem Cell Studies

The Russian pharmaceutical and healthcare markets have a lot of potential for stem cell studies and clinical trials in general. Key strengths of the region include fast patient enrollment, large clinical trial participation and favorable currency exchange rates. Fast patient enrollment is especially essential for early-stage trials to allow for faster project initiation. Some US and European corporations might be cautious to enter the market because of language barriers or logistic issues. However, these concerns can be avoided by choosing a reputable CRO with experience

It is high time for the biomedicine and stem cell industry in our country to enter the phase when it is possible to grow and develop within the regulatory framework. Understanding the registration procedures and a solid regulatory platform, without doubt, create a very favorable environment to launch progressive stem cell studies in Russia, commented Dmitry Sharov, president of OCT, a CRO located in Russia and Eastern Europe. In the upcoming years, we will witness a giant leap in the development of new treatment methods.

The first uptick in medical product applications is already being seen as the first licensing application for a cartilage restoration BCP was filed in February. Despite the fact that this technology has been in development since 2016, it is just now possible to apply for a license as the new bill is being implemented.

About OCT

OCT is a leading full-service CRO serving Russia and Eastern Europe. OCT offers a full range of services to manage Phase 1-4 and BE studies, as well as offering standalone services, such as medical writing, consulting, project management and monitoring, and data management and biostatistics. More information can be found on their website.

This article was provided by OCT and modified by Chelsea for clarity.

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Gene Therapy : Homology Medicines

April 30th, 2019 3:56 pm

Homology Medicines gene therapy approach utilizes our proprietary AAVHSC vectors to deliver a functional gene to a cell where there is a missing or mutated gene. Once delivered, the functional gene may lead to therapeutic protein expression. With gene therapy, the genes do not integrate into the genome so this approach can be curative in slow- or non-dividing cells (e.g., adult liver or central nervous system).

Our gene therapy construct includes a functional copy of the gene and a promotor sequence that is designed to enable the gene to be turned on in the cell and ultimately transcribed to express a therapeutic protein without integrating into the genome.

Our unique vectors have demonstrated significant systemic biodistribution to multiple tissue types in preclinical studies, including liver, central nervous system (CNS), muscle (skeletal and cardiac) and eye*. This enables us to potentially address a broad range of monogenic diseases.

Our lead development program is an AAVHSC-mediated gene therapy treatment for adults with the rare disease phenylketonuria. Learn more about our pipeline and therapeutic focus.

*Homology data on file; Ellsworth JL, Smith LJ, Rubin H, et al. Widespread transduction of the central nervous system following systemic delivery of AAVHSC17 in non-human primates. American Society of Gene & Cell Therapy Annual Meeting. May 2017.

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Integrative Medicine Of NYC | Top Integrative Medicine …

April 30th, 2019 12:52 am

Mary-Laura Klesaris MD

Dr. Mary-Laura Klesaris is a compassionate and energetic Integrative Medicine Doctor at Integrative Medicine of NYC,who takes a multidimensial, evidence based approach to medicine with a focus on bioidentical hormone therapy and seeks to treat the root cause of physical and emotional health issues, including anxiety, depression, insomnia, headaches, menopause, weight gain and chronic fatigue/pain. She is committed to cultivating strong relationships with her patients and collaborates with each patient to help them attain their health and wellness goals.

In addition to nineteen years of experience in internal medicine as well as extensive post-graduate training in age management, Dr. Klesaris completed a fellowship in bio-identical hormone replacement therapy with Dr. Sangeeta Pati, whose distinguished Sajune Institute for Restorative and Regenerative Medicine in Orlando, Florida, is among the most acclaimed centers in the country practicing restorative medicine. Her Five Point Restorative approach includes VortexHealing sessions from practitioner, Susan Hwang, and consultation with a functional nutritionist.

Dr. Klesaris is completing her fellowship in regenerative medicine through the American Academy of Age Management Medicine (A4M). She graduated from St. Georges University School of Medicine and was appointed Chief Medical Resident at the Mt. SinaiCabrini Hospital program in New York City.

Note: sees patients age 18 and older.

Interests:

Bioidentical Hormone Replacement Therapy

Exercise, Nutrition, Weight Management

Lifestyle Modification

Preventive Health and Education

Stress Management

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Integrative Medicine | Long Island, New York | Oasis Medicine

April 30th, 2019 12:52 am

my passion is to empower and transform you, to go beyond disease, pain and suffering and find your true vitality! Dr. DAve

common Conditions we treat

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Autoimmune Disease

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~ Dr. Dave & The Oasis Family

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Genomics and Medicine | NHGRI

April 30th, 2019 12:52 am

It has often been estimated that it takes, on average, 17years to translate a novel research finding into routine clinical practice. This time lag is due to a combination of factors, including the need to validate research findings, the fact that clinical trials are complex and take time to conduct and then analyze, and because disseminating information and educating healthcare workers about a new advance is not an overnight process.

Once sufficient evidence has been generated to demonstrate a benefit to patients, or "clinical utility," professional societies and clinical standards groups will use that evidence to determine whether to incorporate the new test into clinical practice guidelines. This determination will also factor in any potential ethical and legal issues, as well economic factors such as cost-benefit ratios.

The NHGRIGenomic Medicine Working Group(GMWG) has been gathering expert stakeholders in a series of genomic medicine meetingsto discuss issues surrounding the adoption of genomic medicine. Particularly, the GMWG draws expertise from researchers at the cutting edge of this new medical toolset, with the aim of better informing future translational research at NHGRI. Additionally the working group provides guidance to theNational Advisory Council on Human Genome Research (NACHGR)and NHGRI in other areas of genomic medicine implementation, such as outlining infrastructural needs for adoption of genomic medicine, identifying related efforts for future collaborations, and reviewing progress overall in genomic medicine implementation.

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Genomics and Medicine | NHGRI

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Whole Body MRI Human Longevity, Inc.

April 30th, 2019 12:50 am

Sure, medical centers across the country have magnetic resonance imaging, or MRI, machines. But what makes the Health Nucleus MRI different?

First, in traditional medical care, its nearly impossible to get access to a whole body MRI without a significant medical reason. If you injure your knee, only your knee will be scanned in a standard medical MRI, for fear something else in the rest of the body may be seen or not seen and therefore opening the health system up for serious liability concerns.

At the Health Nucleus, we partner with you to take control of your health by actively enrolling in a whole body MRI, and we are equipped to review and interpret your entire scan to generate an unprecedented snapshot of your current health.

Protocols Not Available Anywhere Else

Without the use of contrast media that leaves many feeling nauseous, but whose purpose is to illuminate differences in the body, our MRIs secret sauce is found in our post-processing analysis.

Our proprietary software uncovers cancer, neurological, metabolic and cardiovascular concerns at their earliest stages when they can be addressed.

And unlike traditional medical care, our Health Nucleus is prides itself on a spa-like setting whose luxuries are on the level of our pioneering science. Our MRI techs take pride in ensuring your comfort and calmness in our MRI with guided meditation, aroma therapy, and audio-visual distraction should you wish.

Challenge your perspective on health. Learn how our Health Nucleus MRI might impact you and your health.

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Whole Body MRI Human Longevity, Inc.

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Journal of Nanomedicine and Biotherapeutic Discovery- Open …

April 30th, 2019 12:50 am

Nanomedicine is an application of nanotechnology which made its debut with greatly increased possibilities in the field of medicine. Nanomedicine desires to deliver research tools and clinically reformative devices in the near future.

Journal of Nanomedicine & Biotherapeutic Discovery is a scholarly open access journal publishing articles amalgamating broad range of fields of novel nano-medicine field with life sciences. Nanomedicine & Biotherapeutic Discovery is an international, peer-reviewed journal providing an opportunity to researchers and scientist to explore the advanced and latest research developments in the field of nanoscience & nanotechnology.

This is the best academic journal which focuses on the use nanotechnology in diagnostics and therapeutics; pharmacodynamics and pharmacokinetics of nanomedicine, drug delivery systems throughout the biomedical field, biotherapies used in diseases treatment including immune system-targeted therapies, hormonal therapies to the most advanced gene therapy and DNA repair enzyme inhibitor therapy. The journal also includes the nanoparticles, bioavailability, biodistribution of nanomedicines; delivery; imaging; diagnostics; improved therapeutics; innovative biomaterials; regenerative medicine; public health; toxicology; point of care monitoring; nutrition; nanomedical devices; prosthetics; biomimetics and bioinformatics.

The journal includes a wide range of fields in its discipline to create a platform for the authors to make their contribution towards the journal and the editorial office promises a peer review process for the submitted manuscripts for the quality of publishing. Biotherapeutics journals impact factors is mainly calculated based on the number of articles that undergo single blind peer review process by competent Editorial Board so as to ensure excellence, essence of the work and number of citations received for the same published articles.

The journal is using Editorial Manager System for quality peer review process. Editorial Manager is an online manuscript submission, review and tracking systems. Review processing is performed by the editorial board members of Journal of Nanomedicine & Biotherapeutic Discovery or outside experts; at least two independent reviewers approval followed by editor approval is required for acceptance of any citable manuscript. Authors may submit manuscripts and track their progress through the system, hopefully to publication. Reviewers can download manuscripts and submit their opinions to the editor. Editors can manage the whole submission/review/revise/publish process.

Submit manuscript at http://editorialmanager.com/chemistryjournals/ or send as an e-mail attachment to the Editorial Office at[emailprotected]

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Top 10 Destinations for Stem Cell Therapy – PlacidWay

April 29th, 2019 11:52 am

Top 10 Destinations for Stem Cell Therapy

Stem Cell Therapy has made tremendous progress over the past decade. The years of approved clinical trials have shown that stem cell therapy works for certain conditions. Patients should understand that although stem cell therapy can do wonders for some diseases and illnesses, it is not for everything and everyone.

Before choosing to undergo stem cell therapy patients should undergo a thorough research about the viability of the treatment in a certain country. Unfortunately, there are many clinics which state that they are accredited and that their treatment is approved, only to attract patients and money. Stem cell therapy can be categorized into:

1. Clinically-proven stem cell therapy

Such a clinical trial program costs millions of dollars, therefore only a few accredited institutions and centers had the possibility to undergo such programs.

2. Non-approved stem cell therapy in accredited centers

Competent physicians working in accredited centers can offer non-approved stem cell therapies, as long as the patient is informed about the risks and the lack of scientific support.

3. Fraudulent stem cell therapy

Stem cell therapy can be offered by clinics with no accreditation and by physicians with questionable competency. They are the ones who do exaggerated promotional claims about the efficacy and safety of the stem cell therapy, which has no scientific backing.

Studies made so far suggest that stem cells have the potential of developing into different types of cells and so repair the tissue and organs affected by various medical conditions. There are hundreds of different stem cells in our bodies, which are formed at different times in our lives and with different purposes. The embryonic stem cells are found only in the early stages of development, while adult stem cells develop and remain in our bodies the entire life.

Stem cell therapy gives hope where mainstream medical science fails to offer results. So far, the most common stem cell therapy is blood stem cell transplantation for conditions and diseases of the blood, the immune system or to restore the blood after treatments for certain cancer types. Some injuries or diseases of the bone, cornea or skin can be treated using grafted tissue which depends on stem cells from these parts of the body. But people should understand that like any other type of treatment, stem cell therapy can have side effects, and these can vary from individual to individual.

As people will try anything to see at least a slight improvement in their health or their dear ones, more and more are flocking to other countries and to clinics which promote safe and successful stem cell therapy for a multitude of serious conditions. Stem Cell Tourism, as it is called, is in a continuous expansion as patients want to try the promising therapy. But which are the best destinations for stem cell therapy?

South Korea has made tremendous progress in stem cell research, thanks to the country's flexible policies in this matter. Scientists have been able to develop stem cells which genetically match patients of all genders, ages, and races, which means that they can produce stem cells that fit each individual's needs and with a lower risk of rejection. South Korea might soon get to the forefront of stem cell research.

Singapore, also considered Asia's stem cell center, has more than 40 stem cell research centers. Over the years the country has attracted top scientists from all over the world, offering them a host of incentives and the authorization to use embryos for research. This has helped the country to become one of the top stem cell destinations.

China, world famous for its acupuncture and traditional Chinese medicine, plans to become a leader in stem cell research and development. In 2012, the Ministry of Health and the Ministry of Science started to evaluate all stem cell centers that were functioning illegally. This is of utmost importance for future medical tourists who will seek approved and safe stem cell therapy in China.

Stem Cell clinics: Beike Biotech, ReLife International Medical Center

It has been years since patients from the US and Canada have started choosing this destination to get stem cell therapy for serious medical conditions such as paralysis, autism or cerebral palsy. Mexico continues to make tremendous progress in this area and provide safe stem cell therapy.

Stem Cell clinics: Progencell-Stem Cell Therapies

Germany continues to attract patients coming from all over the world for stem cell therapy. The country is known as Europe's Stem Cell hub, thanks to the tremendous progress made in the Adult Stem Cell research and development.

Stem Cell clinics: Anova IRM Medical Center

Stem Cell therapy in Ukraine has helped hundreds of patients suffering from cirrhosis, pancreatic necrosis, burn disease, hepatitis, diabetes, critical lower limb ischemia and multiple sclerosis. The positive results of the therapy, continue to attract international patients.

Stem cell clinics: EmCell Clinic, Unique Cell Treatment Clinic

Austria is another destination preferred by medical tourists for stem cell therapy. Stem cell therapy in Austria has offered a chance to a normal life to patients suffering from Diabetes, Eye Diseases, Neurological Diseases, Gonarthritis or Peripheral vascular disease.

Stem Cell clinics: Stem Cell Therapy Center Vienna

After the US, Turkey has the highest number of JCI accredited healthcare institutions in the world. Turkey is fast-tracking stem cell research and development with new approaches being tested by renowned scientists and physicians. Patientsfrom Europe, Asia, and the Middle East come here to take advantage of the benefits offered by stem cell therapy.

Stem Cell clinics: Leading International Vision LIV Hospitals

Another stem cell therapy leader in Asia is Thailand, a country which, for the past few years has taken stem cell research to the next level by producing cardiac muscle from human embryonic stem cells, successfully using adult stem cells to treat arthritis and discovering a method to extract stem cells from a human amniotic fluid.

Although stem cell therapy might seem for many the last hope, we advise those who begin this journey to look for and seek help from specialists in this type of medical procedure. Experts will help you choose a safe medical destination and a high-quality hospital. Most of all you must understand that stem cell therapy can help some patients, but never cures them.

Being informed and doing a thorough research about what destination, clinic, and doctor to choose is a must when taking such a decision. Get as much information as you can about the center where you plan to undergo the treatment, try to get real patients testimonials, clinical data evaluation, find out about the centers' and doctors' credentials, detailed evaluation of the procedure they use, what methods and types of stem cells they provide, the real cost of the treatment with all expenditures included (airplane, accommodation, meals, hospital and other fees, etc).

By getting informed you will feel more secure, andtraveling abroad for medical carewill be a positive life-changing experience.

PlacidWay can offer you all the information you need for a successful medical experience overseas. Contact us and get more information about any Stem Cell Therapy on our website.Do not hesitate to contact us!

Disclaimer

Stem Cell Therapy is still an experimental treatment. Any information related to Stem Cell Therapy provided on this website is for educational purposes only. It is not intended to either replace a consultation with a licensed physician or be construed as medical advice or any emergency health need you may be experiencing.

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Top 10 Destinations for Stem Cell Therapy - PlacidWay

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National Blindness Professional Certification Board

April 26th, 2019 1:48 pm

The National Blindness Professional Certification Board (NBPCB) was created to certify qualified specialists in work with the blind. At present, the Certification Board oversees four certifications - the National Orientation and Mobility Certification (NOMC), the National Certification in Rehabilitation Teaching for the Blind (NCRTB), the National Certification in Literary Braille (NCLB), and the National Certification in Unified English Braille (NCUEB).

The National Orientation and Mobility Certification (NOMC) emphasizes nonvisual instruction, and Structured Discovery Cane Travel .

The National Certification in Rehabilitation Teaching for the Blind (NCRTB) emphasizes nonvisual instruction through Structured Discovery Rehabilitation Teaching methods and principles.

The National Certification in Literary Braille (NCLB) is specifically intended for teachers working with blind children or adults. All those who are certified will hold valid certification until their expiration date; however, it is no longer offered and has been replaced with the NCUEB.

The National certification in Unified English Braille (NCUEB) is specifically intended for professionals working with blind children or adults.

The NBPCB has also developed an approval process for orientation training centers who utilize Structured Discovery methodology throughout their programs and a consumer-focused approach.

Subscribe to the O&M Announcement List

Subscribe to the Braille Announcement list

For details regarding how to schedule any of our certification exams in your area, please contact us atadmin@nbpcb.org.

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National Blindness Professional Certification Board

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What Is Regenerative Medicine? – Pain Doctor

April 26th, 2019 1:46 pm

One of the most promising and rapidly developing areas in the treatment of pain is regenerative medicine. These treatments helpthe body heal or rebuild itself. While, the body can naturally heal many types of injuries, newer techniques, such as stem cell therapy, may enhance the bodys ability to heal. But, what is regenerative medicine and how does it work?

Regenerative medicine uses cutting-edge therapies to help the body replace, re-engineer, or regenerate human cells, tissues, or organs that were damaged or injured. The most common applications of regenerative medicine are in new organ growth orrepair and cellular therapies. These both use a patients own cells to stimulate repair tissue and improve function.

The AABB reports that up to one in three people in the U.S. could benefit from regenerative medicine.

Patients with osteoarthritis of the hips and knees can use PRP therapies to stimulate the bodys own healing processes and reduce inflammation. Stem cell therapy could be used to revitalize worn-out intervertebral discs.In the very near future, patients could benefit from lab-grown bladder or heart transplants. These transplants would be derived from the patients very own cells to reduce the risk of transplant rejection or infection.

Regenerative medicine began when the first bone marrow and solid organ transplants were done decades ago. The first successful kidney transplant was in 1954. Successful liver, pancreas, and heart transplants took place in the 60s. From this perspective, regenerative medicine is a fairly established medical practice.

From there, regenerative medicine arose as atruly a cross-disciplinary approach to healthcare. As UPMC notes:

Regenerative medicine is a new field that brings together experts in biology, chemistry, computer science, engineering, genetics, medicine, robotics, and other fields to find solutions to some of the most challenging medical problems faced by humankind.

In the following TED talk, Alan Russell talks a bit aboutthe history of regenerative medicine andwhy so many healthcare professionals are excited about its potential uses.

There are three main types of regenerative therapy, as ARMI explains:

While scientists are working on new types of regenerative medicine that can actually create new body parts from a patients own cells and tissues, this research is still in its infancy. Regenerative medicine for self-repair and cellular therapy, however, is performed on patients today.

Regenerative cellular and self-repair therapies use the following processes:

When an embryo is developing in the womb, it starts out as a mass of stem cells. As the embryo grows, the stem cells multiply and become the specialized cells that make up a body.

Stem cells are body cells that have the potential to become the cells for many types of bodily tissues. Human embryos are a widely recognized and controversial source of stem cells, but stem cells can also be found in the body tissues of adults, such as bone marrow and blood as well as placental tissue. Other adult cells (e.g., skin cells) can be modified through the injection of specific genes or molecules to become stem cells. The various sources of stem cells often have different properties. They are generally capable of becoming some, but not all, types of cells.

Various treatments that involve the extraction of stem cells and their injection into damaged tissues have been developed. Some of these treatments involve taking a persons own stem cells and injecting them into a site of injury. Other treatments rely on stem cells from adult donors. Bone marrow is perhaps the most commonly-accessed source of adult stem cells for regenerative therapies. However, harvesting stem cells from bone marrow is still a surgical procedure requiring anesthesia or sedation.

Though medical research on these treatments is progressing, stem cell treatments are generally considered experimental. They are only approved in the United States as a part of clinical trials. These treatments hold great promise because they may be able to treat certain conditions, such as discogenic back pain, that are difficult to effectively relieve with other methods.

This video from Mayo Clinic gives a quick primer on stem cells.

Another regenerative medicine treatmentis called platelet rich plasma (PRP) therapy. This technique was developed in the 1970s and has been adopted in a variety of medical practices, such as orthopedic surgery, plastic surgery and sports medicine. This treatment gained wider recognition after a number of professional athletes were reported to use it to aid in their recoveries.

PRP therapy involves drawing a small volume of blood from the patient and spinning this blood in a centrifuge. This separates the blood into different layers, each containing concentrated amounts of the substances naturally found in blood: serum in the top layer, white blood cells and platelets in the middle layer, and red blood cells in the bottom layer.

The middle layer, known as PRP concentrate, is then separated from the rest of the blood. This PRP concentrate contains three to five times the normal concentration of the platelets and growth factors that are used in the bodys own healing process. This PRP concentrate is then injected back into the patients body at the site of their injury, for example, into the site of an injured tendon or ligament. This process is then repeated over the course of weeks with additional PRP concentrate being drawn and injected each time.

The platelets injected release hundreds of different proteins involved in the regeneration of tissues. Though research on this treatment continues, the existing research has shown increased healing of several different types of body tissues. Because the patient is injected only with concentrate from their own blood, PRP therapy avoids safety issues of ensuring donor compatibility when using blood and tissue donation.

A pain doctor from Arizona explains how platelet-rich plasma therapy works. You can also find out more about PRP therapy in our posts on the subject.

The process for acquiring the cells for regenerative therapy is different for each type, but the application of the therapy is a simple, straight-forward process no matter the cell type.

The acquisition of adult stem cells typically requires surgery. Amniotic cells come from the amniotic membrane of the placenta, so a placenta is required. This can be a patients own placenta thats been saved, or it can be from a family member. Immediate family members are more likely to be a close-enough match to ensure the cells wont be rejected.

Platelet-rich plasma requires a blood draw. A patients blood is spun in a centrifuge to separate the platelets. The concentrated platelets are combined with residual blood, and the resultant compound is injected into the painful location on the body. From beginning to end, the process of drawing and preparing the blood and injecting the platelet-rich plasma takes between one and two hours.

After the regenerative cells have been injected, the patient is usually able to go home immediately. While physicians often suggest avoiding any strenuous activity for a few days, its possible to go back to regular day-to-day activities right away. Some irritation, soreness, bruising, or other minor discomforts might be present for a few days, but generally there are few side effects of regenerative therapy.

The injected regenerative cells should stimulate the healing and the growth of new tissue. For instance, in degenerative conditions like osteoarthritis, this may mean the growth of new cartilage around joints. With torn muscles or ligaments, regenerative therapy should support the growth of new tissues to heal the injury.

Chronic pain is often the after-effect of degeneration, injury, or illness. Part of the body is left damaged somehow, and that damage causes pain. Most pain therapies concentrate on controlling the pain with medications, injections, or devices that block pain signals in one way or another.

Regenerative therapies are well-suited to treating musculoskeletal pain, or pain thats caused by something in the muscles or bones. Conditions that can respond well to regenerative therapies include:

Compared to other chronic pain therapies, regenerativemedicine has an extremely low risk of side effects.

Regenerative therapies typically involve nothing more than an injection to the painful area of the body, making them very safe. Because the injected compound, whether its stem cells, amniotic cells, or platelet-rich plasma, is usually from the patients own body to begin with, theres almost no risk of infection.

Additionally, one of the biggest risks in the transplant of biological materials, such as organ transplants, is rejection. This is when the body realizes that the transplanted material is foreign and attacks it. However, since the cells used in regenerative therapy are the patients own natural cells, there is no chance at all of rejection.

Stem cell therapy utilizing adult stem cells from the bone marrow is the exception. The harvesting process requires a surgical procedure, which carries the same risks as any other surgery. If, however, the procured stem cells are used on the same person theyre from, this still has the benefit of being extremely low-risk for infection, with no risk of rejection.

It often takes at least two weeks to notice any difference in pain after regenerative therapy, although in some people it may take even longer. In some cases, there may be no discernable pain reduction after regenerative therapy. However, because of its low risk of side effects, it may still be worth discussing this treatment option with a physician.

Regenerative medicine is already available today, in many different applications. According to the NIH:

Naturealso keeps a running list of the scholarly articles about current regenerative medicine research and trials.

As to wide-spread availability of these therapies, that depends. Since stem cell and regenerative medicine is still in its infancy, many insurance providers dont cover the cost of these procedures. That means many procedures are paid out of pocket. You may find discounted optionsby reaching out to pain clinics and independent medical groups who are performing their own studies and patient trials onregenerative medicine.

Once there is more solid research backing these procedures, regenerative medicine should become more easily available and cost-effective for all patients.

From made-to-order organs to smart biomaterials that could help form functional tissues, the possibilities and future of regenerative medicine is endless. The NIH notes:

Imagine a world where there is no donor organ shortage, where victims of spinal cord injuries can walk, and where weakened hearts are replaced. This is the long-term promise of regenerative medicine, a rapidly developing field with the potential to transform the treatment of human disease through the development of innovative new therapies that offer a faster, more complete recovery with significantly fewer side effects or risk of complications.

Organizationslike the Stanford Medicine Institute for Stem Cell Biology and Regenerative Medicine and Mayo Clinics Center for Regenerative Medicine areat the forefront of researching new applications for regenerative medicine.

Many healthcare researchers today are grappling with the questions of what is regenerative medicine and what potential uses it can have for patients. To learn more about the future of regenerative medicine, check out the following articles:

Regenerative medicine clinics can be found in larger medical institutions like Mayo Clinic or Stanford Medicine, however there are also local doctors in your area who are running stem cell and regenerative medicine trials for their patients. Pain clinics, in particular, are offering regenerative therapies for conditions like arthritis and back pain.

You can find a pain clinic in your area by clicking the button below. The clinicsServices page will list which regenerative therapies they offer. Or, you can call their office and ask.

Originally posted here:
What Is Regenerative Medicine? - Pain Doctor

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False hope for autism in the stem-cell underground …

April 25th, 2019 9:48 am

Scientific interest in stem cell therapies for autism began from one doctors observation.

In the late 1980s, Joanne Kurtzberg, a pediatrician specializing in blood cancers, worked with Hal Broxmeyer, who had been studying the stem cells present in blood from umbilical cords preserved at birth. Since the 1950s, doctors have treated blood cancers using transplants of bone marrow, which contains adult stem cells capable of generating blood cells. But as Broxmeyers group showed, cord-blood stem cells are more potent than adult stem cells at this task. Of particular value, they do not require a perfect match between donor and recipient.

Kurtzberg recognized the promise of cord blood for people of color, who often have trouble finding matching bone-marrow donors. So, in 1998, she founded the Carolinas Cord Blood Bank at Duke University and, in 2005, helped pass legislation to establish a national network of similar banks. Every year in the U.S., about 200,000 women donate cord blood from their babies to these public banks or to research labs; families also pay to store up to 7 million units of cord blood in private banks worldwide, though these samples rarely end up being used. In 2011, the FDA began requiring companies selling therapies developed from cord blood to submit data showing their safety and effectiveness.

In the late 1990s, Kurtzberg says she noticed something curious following cord blood transplants in children with certain metabolic conditions who also have autism traits. The transplants not only extended their lives but also seemed to prevent brain deterioration and improve brain function. Kurtzberg theorized that the stem cells in the cord blood might be engrafting in the brain and repairing damaged tissue. Other cells in the cord blood might also be sending chemical signals across the blood-brain barrier to lower inflammation, which is seen in some people with autism, she says.

To test the inflammation theory, Kurtzberg began collaborating with Geraldine Dawson, an autism researcher also at Duke. In 2014, they launched a clinical trial with $40 million in funding from the Marcus Foundation, a nonprofit based in Atlanta that supports a variety of causes. The foundations head, Home Depot co-founder Bernie Marcus, has called himself a real advocate for stem cells for autism, and he reportedly told the controversial leader of the Panama stem cell clinic the Perskins visited that he hoped to get approval from the FDA.

The Duke trial drew immediate criticism. In 2014, Arnold Kriegstein, a neural stem cell expert at the University of California, San Francisco, told Spectrum the study was a Hail Mary pass and that it was unlikely cord-blood stem cells could reverse autism-related changes to the brain during early development. None of their explanations hold water on why it would have any therapeutic value, Kriegstein now says. Paul Knoepfler, a researcher at the University of California, Davis who blogs about the stem cell industry, also expressed skepticism, noting that autisms causes are too diverse and mysterious for the therapy to make sense.

Still, the Duke team published encouraging results from the safety phase of the trial in 2017. Clinicians working with the researchers evaluated 22 of the participants, all between the ages of 2 and 5 years, and documented improvements in 13 of them six months after a single infusion. Without a control group, it is impossible to say whether the children would have improved anyway. A follow-up report found that those who improved showed increased connectivity in brain regions affected by autism, including the limbic system, but the researchers published no evidence to support their inflammation theory.

Because there were no adverse effects from the infusions, in November 2017 the FDA granted Kurtzberg special approval to provide cord blood infusions to certain children, including some with autism. Kurtzberg declined to say how much the treatments cost but confirmed that the parents from other countries are required to put down a $15,000 deposit; the money covers a 45-minute intravenous infusion of their childs own cord blood or that of a matched sibling. Kurtzberg says her team plans to treat about 1,000 children per year, and that they have a waiting list of more than a year. She expects to publish the results of a placebo-controlled phase of the trial sometime this year, comparing children who receive cord blood infusions with those who do not.

While the Duke trial pushes forward, others have sputtered. A 2018 clinical trial at the Sutter Institute of Medical Research in Sacramento, California, found minimal evidence of clinical effectiveness of cord blood infusions given to 29 autistic children. The National Institutes of Health clinical trials registry lists 11 other autism-related stem cell trials but 3 concluded years ago without registering any results, 3 are listed with an unknown status, and 2 have been withdrawn. Most are outside the U.S., and none randomized the participants to receive the therapy or placebo, which is considered the gold-standard approach in clinical trials. Some may even be pay-to-participate trials, which are little more than marketing ploys to lure customers, Turner says.

Kurtzberg acknowledges that her research has led to a boom in questionable stem cell providers but says her team members do their best to tell families to tread carefully. We dont want to promote a therapy thats not helpful, she says.

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False hope for autism in the stem-cell underground ...

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About Us l Ophthalmology l University Hospitals l …

April 25th, 2019 9:46 am

Under the direction of Douglas Rhee, MD, who is recognized as one of the nations leading glaucoma experts, University Hospitals Eye Institute delivers superior patient care, advanced clinical technology and pioneering research to seniors, adults and children from five centers of Excellence:

Patients, families and referring physicians benefit from convenient access to superior patient care, advanced clinical technology and pioneering research. We provide a full spectrum of ophthalmology services, including routine eye examinations, medical and surgical care for simple and complex vision disorders, inpatient consultations, diagnostic testing, and simple and complex adult and pediatric contact lens fittings.

At UH Eye Institute, we provide a variety of options because we understand that each person is different. Its why our nationally-renowned experts team up to design customized care plans tailored to meet the individual needs of our patients and their families.

Our physicians also work in partnership with the greater Cleveland community through volunteerism, committee memberships and service as board members and trustees. Our outreach includes Eversight, Cleveland Sight Center, Free Clinic (now Circle Health Services), Ohio Lions, and Prevent Blindness Ohio, which provides over 1,000 free eye exams per year to people without health insurance.

Link:
About Us l Ophthalmology l University Hospitals l ...

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Mark Armando Prendes MD Doctor Profile & Reviews …

April 25th, 2019 9:46 am

University Hospitals is committed to transparency in our interactions with industry partners, such as pharmaceutical, biotech, or medical device companies. At UH, we disclose practitioner and their family members ownership and intellectual property rights that are or in the process of being commercialized. In addition, we disclose payments to employed practitioners of $5,000 or more from companies with which the practitioners interact as part of their professional activities. These practitioner-industry relationships assist in developing new drugs, devices and therapies and in providing medical education aimed at improving quality of care and enhancing clinical outcomes. At the same time, UH understands that these relationships may create a conflict of interest. In providing this information, UH desires to assist patients in talking with their practitioners about industry relationships and how those relationships may impact their medical care.

UH practitioners seek advance approval for certain new industry relationships. In addition, practitioners report their industry relationships and activities, as well as those of their immediate family members, to the UH Office of Outside Interests annually. We review these reports and implement management plans, as appropriate, to address conflicts of interest that may arise in connection with medical research, clinical care and purchasing decisions.

View UHs policy (PDF) on practitioner-industry relationships.

As of December 31, 2016, Mark Armando Prendes did not disclose any Outside Relationships with Industry.

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Dry Eye Center | University Hospitals | Cleveland, OH …

April 25th, 2019 9:46 am

The Dry Eye Center at University Hospitals Eye Institute offers unique treatments for patients suffering from dry eye disease. Our specialists are trained to treat patients using minimally invasive surgical techniques, as well as with a wide array at-home dry eye treatments and non-invasive therapies conveniently available to patients in our offices.

Our innovative optometrists and ophthalmologists have created the only dry eye center of excellence in the Cleveland area. Our providers are proud to offer a wealth of knowledge and treatments that are unique and effective. We are determined to ease our patient's dry eye symptoms and provide education on how to manage symptoms.

Our use of the Prokera Slim, an amniotic membrane, sets our program apart from other practices. View the video below to learn how Prokera Slim could cure you of your dry eye symptoms.

We take great pride in delivering compassionate and advanced care that is highly sensitive to our patients' individual needs by bringing together trained specialists, including:

To request more information, contact the Dry Eye Center at 216-844-3601.

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Dry Eye Center | University Hospitals | Cleveland, OH ...

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Erik Moffat Ostler MD Doctor Profile & Reviews …

April 25th, 2019 9:46 am

University Hospitals is committed to transparency in our interactions with industry partners, such as pharmaceutical, biotech, or medical device companies. At UH, we disclose practitioner and their family members ownership and intellectual property rights that are or in the process of being commercialized. In addition, we disclose payments to employed practitioners of $5,000 or more from companies with which the practitioners interact as part of their professional activities. These practitioner-industry relationships assist in developing new drugs, devices and therapies and in providing medical education aimed at improving quality of care and enhancing clinical outcomes. At the same time, UH understands that these relationships may create a conflict of interest. In providing this information, UH desires to assist patients in talking with their practitioners about industry relationships and how those relationships may impact their medical care.

UH practitioners seek advance approval for certain new industry relationships. In addition, practitioners report their industry relationships and activities, as well as those of their immediate family members, to the UH Office of Outside Interests annually. We review these reports and implement management plans, as appropriate, to address conflicts of interest that may arise in connection with medical research, clinical care and purchasing decisions.

View UHs policy (PDF) on practitioner-industry relationships.

As of December 31, 2016, Erik Moffat Ostler did not disclose any Outside Relationships with Industry.

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Erik Moffat Ostler MD Doctor Profile & Reviews ...

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