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Stem Cell Therapy – Scott Medical Center

September 23rd, 2017 3:48 pm

At Scott Medical Center, non-invasive medical procedures are the mainstay of our practice. Using the most up to date techniques, our staff treats patients as whole people, providing a comprehensive diagnostic assessment in order to design a customized strategy for relief from medical concerns. Stemcell research, for example, has advanced to a point that, at Scott Medical Center, stemcell injections as part of our array of treatments, designed to help our patients attain their wellness goals and achieve a higher quality of life.

For instance, until recently, treatment options for people with osteoarthritis of the knee were limited. Steroid injections, joint replacement surgery, and physical therapy were often the only treatment options. Now, stemcell injections for knee osteoarthritis are available, at Scott Medical Center. Stemcell therapy also has applications for treating Achilles tendonitis, rotator cuff tendonitis, and degenerative arthritis.

Stemcell injections work with the bodys natural ability to heal itself. Unlike treatments that simply address the symptoms, stemcell therapy actually promotes repair of the body, restoring degenerated tissue. Stemcell injections also contain hyaluronan, which eases pain and restores mobility by lubricating joints and tendons. This therapy fits well with Scott Medical Centers integrated approach to wellness, addressing the source of issues, rather than just treating the symptoms.

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Research – Rutgers New Jersey Medical School

September 23rd, 2017 3:46 pm

The members of the Department of Microbiology, Biochemistry and Molecular Genetics at New Jersey Medical School of Rutgers Biomedical and Health Sciences (RBHS) are investigating some of the most intriguing problems facing modern biology, including regulation of gene expression, processing of mRNA, functional genomics, chromosome replication and recombination, regulation of cell growth and tumorigenesis, signal transduction and mechanisms governing bacterial and viral pathogenesis. Many different experimental systems are utilized including bacteria, viruses, yeast, animal cells and protozoa. The department is fully equipped for modern molecular studies and has core facilities available through the medical school for nucleic acid and protein sequencing, cell imaging, mass spectroscopy, FACS and advanced data processing. In 2002, the department occupied the newly constructed International Center for Public Health, which it shares with the renowned Public Health Research Institute Center of NJMS (formerly of New York City) and the NJMS - Global Tuberculosis Institute. The center creates a unique and exciting environment for scientific research.

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Stem Cell Therapy || Treatment Application || Stem Cell …

September 23rd, 2017 3:46 pm

Best Phone* : (include area code)Alternate Phone 1: (include area code)Alternate Phone 2: (include area code)FAX Number: (include area code)Email* :Occupation:Marital Status*:SelectPrivateSingleDivorcedMarriedPartnerSeparatedWidowWidowerParent/Guardian InformationName :Address :Home Phone : (include area code)Office Phone: (include area code)Cell Phone: (include area code)Alternate Phone: (include area code)Physical Limitations*Need Assistance Walking? Yes No *Wheel Chair Needed? Yes No Other Needs :Emergency ContactName* :Relationship* :Phone* : (include area code)Address:City:State or Province:Zip or Country Code:Country:Primary Diagnosis/DiseasePhysician Name* :Physician Phone: (include area code)Primary Disease Diagnosis* :Select Autism Autoimmune Disease Cerebral Palsy Heart Disease Multiple Sclerosis Primary Progressive Multiple Sclerosis Secondary Progressive Multiple Sclerosis Relapsing Remitting Osteoarthritis Rheumatoid Arthritis Spinal Cord Injury Complete Spinal Cord Injury IncompleteOther List Below What is the level of your lesion(s)? (ex. T6, C3)* :Brief Description of Symptoms* :Date of Diagnosis* :Month January February March April May June July August September October November December Day 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Year 1900 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 1918 1919 1920 1921 1922 1923 1924 1925 1926 1927 1928 1929 1930 1931 1932 1933 1934 1935 1936 1937 1938 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951 1952 1953 1954 1955 1956 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 1973 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 Medical Records Available?Medications Now On:Anticoagulated?Anticoagulated Since When:Month January February March April May June July August September October November December Day 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Year 1900 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 1918 1919 1920 1921 1922 1923 1924 1925 1926 1927 1928 1929 1930 1931 1932 1933 1934 1935 1936 1937 1938 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951 1952 1953 1954 1955 1956 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 1973 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 Why Anticoagulated?Subject History: Cancer*Have you ever been diagnosed with any type of cancer? Yes No Cancer Type:Date Cancer Diagnosed:Month January February March April May June July August September October November December Day 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Year 1900 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 1918 1919 1920 1921 1922 1923 1924 1925 1926 1927 1928 1929 1930 1931 1932 1933 1934 1935 1936 1937 1938 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951 1952 1953 1954 1955 1956 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 1973 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 Cancer Status:Subject History: DiabetesAre You Diabetic?Taking Insulin?Subject History: Neurological SystemVision Decrease?Vision Black Spots?Vision Nistagmus?Muscle Weakness?Muscle Wasting?Walking Difficulties?Decreased Hand Strength?Fainting?Speech Problems?Tingling Sensation?Muscle Fasciculations?Spasticity?Hyperreflexia?Hyporeflexia?Depression?Loss of Memory?Headaches?Sleep Disturbances?Dizziness?Subject History: Pulmonary SystemAsthma?Chronic Bronchitis?Chronic Cough?Emphysema?Tuberculosis?Subject History: Cardiovascular ProblemsMyocardial Infarction?Myocardial Infarction Date:Month January February March April May June July August September October November December Day 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Year 1900 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 1918 1919 1920 1921 1922 1923 1924 1925 1926 1927 1928 1929 1930 1931 1932 1933 1934 1935 1936 1937 1938 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951 1952 1953 1954 1955 1956 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 1973 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 Angina Pectoris?Tachycardia?By-Pass Surgery?By-Pass Surgery Date:Month January February March April May June July August September October November December Day 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Year 1900 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 1918 1919 1920 1921 1922 1923 1924 1925 1926 1927 1928 1929 1930 1931 1932 1933 1934 1935 1936 1937 1938 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951 1952 1953 1954 1955 1956 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 1973 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 Hypertension (high blood pressure)?Hypotension (low blood pressure)?Subject History: CirculatoryPoor Arterial Circulation?Poor Venous Circulation?Leg Cramps?Tired Legs?Swollen Ankles?Varicose Veins?Tingling Sensation in Arms and Legs?Falling Asleep of the Hands and Legs?*Ulcers or open wounds anywhere on your body? Yes No Subject History: Gastrointestinal ProblemsAcid Indigestion?Bloating?Stomach or Duodenal Ulcer?Stomach or Duodenal Ulcer Date:Month January February March April May June July August September October November December Day 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Year 1900 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 1918 1919 1920 1921 1922 1923 1924 1925 1926 1927 1928 1929 1930 1931 1932 1933 1934 1935 1936 1937 1938 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951 1952 1953 1954 1955 1956 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 1973 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 Loss of Appetite?Rapid Weight Gain?Rapid Weight Loss?Overweight Problem?Have You Had Upper GI endoscopy?Upper GI Date:Month January February March April May June July August September October November December Day 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Year 1900 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 1918 1919 1920 1921 1922 1923 1924 1925 1926 1927 1928 1929 1930 1931 1932 1933 1934 1935 1936 1937 1938 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951 1952 1953 1954 1955 1956 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 1973 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 Upper GI Results:Hepatitis?Hepatitis Type:Gall Bladder Problems?Gall Stones?Icterus?Recurring Diarrhea?Subject History: Upper Respiratory Test*Chronic Sinusitis? Yes No *Allergic Sinus Problem? Yes No *Chronic Allergic Rhinitis? Yes No *Sinus Headaches? Yes No *Chronic Nose Bleeds? Yes No *Chronic Colds? Yes No Subject History: Rheumatic ScreenSoft Tissue Rheumatism?Articular Rheumatism?Joint Pain?Back Pain?Rheumatoid Arthritis?Other Rheumatic Conditions:Subject History: Endocrinological SystemDiabetes Mellitus?Overactive Thyroid?Underactive Thyroid?Adrenal Gland Dysfunction?Female Menopause?Male Menopause?Other Endocrinological Conditions:Health History Allergy:*Food Allergy, Especially Eggs? Yes No *Hay Fever? Yes No *Allergic Asthma? Yes No *Medication Allergies? Yes No Medication Allergy Symptoms:*Allergies to any vaccinations? Yes No Subject History: OtherWhen was your last vaccination?Month January February March April May June July August September October November December Day 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Year 1900 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 1918 1919 1920 1921 1922 1923 1924 1925 1926 1927 1928 1929 1930 1931 1932 1933 1934 1935 1936 1937 1938 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951 1952 1953 1954 1955 1956 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 1973 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 *Do You Smoke Cigarettes? Yes No *Do You Smoke Cigars? Yes No *Do You Smoke Pipes? Yes No How Much Do You Smoke Per Day?*Do you drink wine? Yes No *Do you drink beer? Yes No *Do you drink hard liquor? Yes No How much do you typically drink per day?*Please list any nutritional supplements you are taking:Other Significant Illnesses:Do You Take Human Growth Hormone?How Long Have You Taken Growth Hormone?Human Growth Hormone Injections per Week:PSA Test (Men Only)?PSA Test Date:Month January February March April May June July August September October November December Day 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Year 1900 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 1918 1919 1920 1921 1922 1923 1924 1925 1926 1927 1928 1929 1930 1931 1932 1933 1934 1935 1936 1937 1938 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951 1952 1953 1954 1955 1956 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 1973 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 PSA Test Result:Periodic Mammograms

(Women only)?

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American Veterinary Medical Association – Home

September 22nd, 2017 12:52 pm

August 29,2017

Find resources you need or learn how you can help those affected by the devastation of Hurricanes Irma and Harvey, and wildfires in the western United States.

August 31,2017

The funds will beused for veterinary disaster reimbursementgrants administered by the American Veterinary Medical Foundation (AVMF).

October 15,2017

Storm impacts small and large animals, urban and rural clinicsBy Katie BurnsPosted Sept. 8, 2017

October 01,2017

Posted Sept. 13, 2017Signs of screwworm infestation were reportedly seen in Florida wildlife and d

October 01,2017

AVMA Convention attendees keep up-to-date with CE and friendsBy Malinda LarkinPosted Sept. 13,

October 01,2017

By Susan C. KahlerPosted Sept. 13, 2017 In his line of work as owner of Compassionate Veterinary

October 01,2017

Posted Sept. 13, 2017Featured are highlights from AVMA Convention 2017 in Indianapolis, where

October 01,2017

Associations for veterinarians, pharmacists working to reduce conflictsBy Greg CimaPosted Sept.

October 01,2017

Posted Sept. 13, 2017 On Aug. 24, Harvey intensified into a hurricane in the Gulf of Mexico. The s

October 01,2017

SAVMA meeting features leadership panel, increased grant fundingBy Malinda LarkinPosted Sept. 1

October 01,2017

Posted Sept. 13, 2017The AVMA Council on Education has scheduled site visits to five schools and c

October 01,2017

States encouraged to beef up wellness resourcesBy Malinda LarkinPosted Sept. 13, 2017 Drs. An

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5 Ethical and Legal Issues | Cord Blood: Establishing a …

September 21st, 2017 10:58 pm

such de-identified material to be exempted from its coverage (Clayton et al., 1995; Clayton, 1995; Bradburn, 2001; OHRP, 2004; Clayton, 2004).

While the de-identification may clear the institution of any obligations under HIPAA or the need for an IRB-approved informed consent procedure, Clayton (2004) explains that public opinion is different, and that most patients still believe they should be informed of all potential research uses of their biological materials and retain some autonomy over their use. Thus, she concludes that research institutions would be best served by working with patients collectively and individually to ensure appropriate oversight.

REFERENCES

Black N. 2003. Secondary use of personal data for health and health services research: Why identifiable data are essential. Journal of Health Services Research Policy. 8(S1):3640.

Bradburn NM. 2001. Medical privacy and research. Journal of Legal Studies 30(2):687701.

Burgess MM, Laberge CM, Knoppers BM. 1998. Bioethics for clinicians. 14. Ethics and genetics in medicine. Canadian Medical Association Journal 158(10):13091313.

Clayton EW. 1995. Why the use of anonymous samples for research matters. Journal of Law, Medicine and Ethics 23(4):375377.

Clayton EW. 2004. So what are we going to do about research using clinical information and samples? IRB 26(6):1415.

Clayton EW, Steinberg KK, Khoury MJ, Thomson E, Andrews L, Kahn MJ, Kopelman LM, Weiss JO. 1995. Informed consent for genetic research on stored tissue samples. Journal of the American Medical Association 274(22):17861792.

FDA (Food and Drug Administration). 2004. Eligibility determination for donors of human cells, tissues, and cellular and tissue-based products. Final rule. Federal Register 69(101): 2978529834.

Fernandez CV, Gordon K, Van den Hof M, Taweel S, Baylis F. 2003. Knowledge and attitudes of pregnant women with regard to collection, testing and banking of cord blood stem cells. Canadian Medical Association Journal 168(6):695698.

Fernandez MN. 1998. Eurocord position on ethical and legal issues involved in cord blood transplantation. Bone Marrow Transplantation 22(Suppl. 1):S84S85.

Gluckman E. 2000. Ethical and legal aspects of placental/cord blood banking and transplant. Hematology Journal 1(1):6769.

Haley NR. 1999. Linking donors to stored cord blood units: Duties to donors and recipients. Cancer Research Therapy and Control 8(4):345346.

HHS (U.S. Department of Health and Human Services Office for Civil Rights). December 3, 2002, revised April 3, 2003. General Overview of Standards for Privacy of Individually Identifiable Health Information. [Online] Available: http://www.hipaadvisory.com/regs/finalprivacymod/goverview.htm [accessed March 2005].

HHS. 2003. Privacy and Your Health Information. [Online] Available: http://www.hhs.gov/ocr/hipaa/consumer_summary.pdf [accessed March 2005].

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NIH Fact Sheets – From Genes to Personalized Medicines

September 21st, 2017 10:57 pm

NIH-supported pharmacogenomics researchers are making steady progress towards understanding how genes influence drug responses. These findings will improve doctors ability to personalize treatment by predicting an individuals response to a drug regimen and pre-empting problems, promising a future of:

Instead of basing a starting dose only on characteristics like weight and age, doctors will use a patients genetic profile to determine the best drug and the optimal dose.

Pharmaceutical companies will be able to develop and market drugs for people with specific genetic profiles. Testing a drug candidate only in those likely to benefit from it could streamline clinical trials and speed the process of getting a drug to market.

Doctors will be able to prescribe the right dose of the right medicine the first time for everyone. This means that patients would receive medicines that are safer and more effective for them, speeding recovery, avoiding adverse reactions, and improving health care overall.

Contact: Office of Communications and Public Liaison National Institute of General Medical Sciences info@nigms.nih.gov 301-496-7301

http://www.nigms.nih.gov

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Foods That Help Your Immune System – 5 Types to Try

September 21st, 2017 10:56 pm

Certain foods may be helpful for boosting theimmune system and preventingcolds and the flu. Here's a look at five types of foods that provide nutrients that your immune system needs to perform:

An essential nutrient, vitamin C acts as an antioxidant. Antioxidants help fight free radicals, a type of unstable molecule known to damage the immune system. There's some evidence that vitamin C may be particularly helpful in boosting the immune systems of people under major stress.

To increase your vitamin C intake, add these foods to your diet:

Like vitamin C, vitamin E is a powerful antioxidant. Research suggests maintaining ample levels of vitamin E is crucial for maintaining a healthy immune system, especially among older people. To get your fill of vitamin E, look to these foods:

Zinc is an essential mineral involved in the production of certain immune cells. The National Institutes of Health (NIH) caution that even mildly low levels of zinc may impair your immune function. Here are some top food sources of zinc:

Another type of antioxidant, carotenoids are a class of pigments found naturally in a number of plants.

When consumed, carotenoids are converted into vitamin A (a nutrient that helps regulate the immune system). Look to these foods to boost your carotenoids:

Omega-3 fatty acids are a type of essential fatty acid known to suppress inflammation and keep the immune system in check.

Although it's not known whether omega-3s can help fight off infections (such as the common cold), research suggests that omega-3s can protect against immune system disorders like Crohn's disease, ulcerative colitis, and rheumatoid arthritis. Try these omega-3-rich foods:

To keep your immune system healthy, it's important to get sufficient sleep, exercise regularly, and manage your stress.

Although supplements containing high doses of antioxidants and other nutrients found in whole foods are often touted as natural immune-boosters, some research indicates that taking dietary supplements may have limited benefits for the immune system. (If you're still considering taking them, it's a good idea to consult your healthcare provider first to weigh the pros and cons.)

For more foods that may help boost your immune system, try adding garlic, foods high inprobiotics(such as yogurt and kefir), and green tea to your diet.

Sources:

Chew BP, Park JS. Carotenoid action on the immune response. J Nutr. 2004 Jan;134(1):257S-261S.

Gill H, Prasad J. Probiotics, immunomodulation, and health benefits. Adv Exp Med Biol. 2008;606:423-54.

Hughes DA. Effects of dietary antioxidants on the immune function of middle-aged adults. Proc Nutr Soc. 1999 Feb;58(1):79-84.

Kyo E, Uda N, Kasuga S, Itakura Y. Immunomodulatory effects of aged garlic extract. J Nutr. 2001 Mar;131(3s):1075S-9S.

Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr. 2002 Dec;21(6):495-505.

Wintergerst ES, Maggini S, Hornig DH. Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab. 2006;50(2):85-94.

Disclaimer: The information contained on this site is intended for educational purposes only and is not a substitute for advice, diagnosis or treatment by a licensed physician. It is not meant to cover all possible precautions, drug interactions, circumstances or adverse effects. You should seek prompt medical care for any health issues and consult your doctor before using alternative medicine or making a change to your regimen.

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National Institutes of Health – SardiNIA

September 21st, 2017 10:55 pm

In a first survey, the project team recruited over 6,100 subjects from a catchment area including four towns in east-central Sardinia and assessed a first list of >200 traits. The baseline survey has been followed by follow-up visits that collected longitudinal data on the same traits collected at baseline but added assessment of frailty-related traits, namely measures of bone density and geometry, muscle strength, and gait speed, and additional cardiovascular measures (see below). In the course of SardiNIA3, along with the expansion of the cohort and the addition of more traits (see below), increases in testing efficiency and additional cost-sharing funds from Sardinian sources permit the completion of Fourth Visits for the entire cohort. Also in current actions, DNA sequencing has recovered essentially all of the genetic variation in the cohort, and further arrangements for an Outcome Study have also been made to be implemented in SardiNIA4, a further 5-year continuation of the Project that also projects Fifth Visits for the cohort.

The infrastructure for the clinic and phenotypic testing has been stable, with stringent quality control, which is reflected in the high quality of the database. The initial sample cohort included over 62% of the eligible population living in the region (age 14-102 years), and at least 96% of the initial cohort have all grandparents born in the same province. The initial group included 4,933 phenotyped sib pairs, 4,266 phenotyped parent-child pairs, >4,069 phenotyped cousin pairs, and >6,459 phenotyped avuncular pairs. Additional recruitment has increased the cohort substantially, and results have consistently shown that for essentially every trait, most of the associated genes and variants would be involved in determining variance in both young and old and in men and women. Thus, genetic analyses can draw on data from all ages and both genders.

The added value of studying a founder population has also been demonstrated by the extension of DNA analysis to the full range of variation by sequencing. The population has proven to contain the great bulk of variation found in other populations, but during its isolation over many thousands of years, many variants rare elsewhere have risen to relatively high levels on the island by drift or selection and others have newly arisen as Sardinian-specific. These have provided extensive new information about a whole range of traits and pathways (e.g., Nature Genetics November, 2015 articles and Editorial).

Sardinia also offers a special entre to the genetics of specific diseases that are especially prevalent in the founder population. This includes the anomalously high incidence of autoimmune diseases including Multiple Sclerosis and Type 1 diabetes, which interrupt the high to low gradient of incidence from Northern to Southern Europe. Again, this has fostered novel findings in causation and pathophysiology.

The founder population itself also contains within its DNA a record of human demography through history, which has permitted the inference of the timing of human population movements based on mitochondrial and Y chromosome analyses.

Regarding the course and mechanism of aging, the longitudinal study, now in its 15th year, focuses on residents of the cluster of towns to collect longitudinal information on more than 400 age-related quantitative traits ("endophenotypes" or "quantitative risk-related genetic or environmental factors") that can be scored on a continuous scale, as well as >200 dichotomous traits (including major diseases and risk factors such as smoking). The use of quantitative traits permits the study of the entire range of allelic variation in a population, with particular interest in a range of cardiovascular risk factors, anthropometric measurements, blood test values, facets of personality, and bone-density and frailty-related variables.

The longitudinal study of a broad range of phenotypes in a founder population is distinctive in this study, and stable environmental/epidemiological factors combined with the simplification of genetic analyses also aid in proposed joint investigations of relative risk. Furthermore, because we are collecting risk factor data, we can also analyze, in an Outcome Study, the prognostic power and/or pathophysiological relevance of earlier predictors for the onset of serious risk factors [e.g., increases in pulse wave velocity as a function of earlier (predictor) lipid and inflammatory markers].

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Stem Cell Cancer Treatment in Panama – health-tourism.com

September 20th, 2017 10:46 pm

This information is intended for general information only and should not be considered as medical advice on the part of Health-Tourism.com. Any decision on medical treatments, after-care or recovery should be done solely upon proper consultation and advice of a qualified physician.

Stem cell cancer treatment

Stem cell cancer treatment is a type of treatment that treats cancer by using stem cell transplant, which is also called peripheral blood stem cell transplant. It is used to try and cure some types of cancer such as myeloma, lymphoma and leukemia. Stem cells are very early blood cells in the bone marrow that develop into red blood cells, white blood cells and platelets. They are needed in order to survive. Your doctor can collect them from a donor or from your blood. After a high dose of treatment which leaves stem cells dead, the stem cells are replaced through an intravenous drip.

Stem cell transplant infuses healthy stem cells into the body to stimulate bone marrow growth, suppress the disease and reduce the possibility of going into remission. Stem cell transplant implies that you can have higher doses of treatment through chemotherapy and radiotherapy. Therefore, the chances of getting cured are higher.

There are two main types of stem cell transplants. You and your doctor will discuss the best choice for you.

This is also known as auto stem cell transplant. Cancer treatment using autologous stem cell transplant uses your own stem cells. It is used mainly to treat myeloma and lymphoma. There is less risk of rejection or graft-versus-host disease, whereby the new donor cells think your cells are foreign and attack them. Ina addition, engraftment is quicker ad side effects are fewer.

How It Works: Your team of doctors collect, freeze and store your own stem cells. You then undergo treatment with chemotherapy or radiation therapy after which your stem cells are thawed and transplanted back into you. You may need to go through the above process twice instead of once. This is known as a tandem or double autologous stem cell transplant.

This type of stem cell transplant is also known as allo stem cell transplant. It involves using stem cells that have been donated. It is mainly used to treat leukemia, aggressive lymphomas and autologous transplants that have failed.

How It Works: Stem cells are donated from a matched donor. You then receive treatment using chemotherapy or radiation therapy after which you receive the donor stem cells.

The type and strength of your high-dose treatment is what will influence any side effects you may have and their severity. Possible side effects include:

After having a stem cell transplant to treat your cancer, you will have regular tests to check your general health. In addition, monitoring the levels of your blood cells, you will have blood tests. Most of the side effects are worse when your blood count is at its lowest. However, as this goes up, the side effects will begin to improve. You will be able to go home when your blood count has reached a safe level.

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Stem Cell Treatment for Optic Neuropathy

September 20th, 2017 10:45 pm

Acupuncture

Acupuncture is a technique in which practitioners stimulate specific points on the body - most often by inserting thin needles through the skin. It is one of the most effective practices used in traditional Chinese medicine. Acupuncture stimulates nerve fibers to transmit signals to the spinal cord and brain, activating the bodys central nervous system. The spinal cord and brain then release hormones responsible for making us feel less pain while improving overall health. Acupuncture may also: increase blood circulation and body temperature, affect white blood cell activity (responsible for our immune function), reduce cholesterol and triglyceride levels, and regulate blood sugar levels.

Aquatherapy

Aquatic Physical Therapy is the practice of physical therapy in a specifically designed water pool with a therapist. The unique properties of the aquatic environment enhance interventions for patients with neurological or musculoskeletal conditions. Aquatic therapy includes a wide range of techniques allowing patients to improve their balance, muscle strength and body mechanics. Aquatic therapy works to enhance the rehabilitation process and support effectiveness of stem cell treatment.

Epidural Stimulation

Hyperbaric Oxygen Therapy

Hyperbaric Oxygen Therapy (HBOT) is the medical use of oxygen at a level higher than atmospheric pressure. The equipment required consists of pressure chamber, which may be of rigid or flexible construction, and a means of delivering 100% oxygen into the respiratory system. Published research shows that HBOT increases the lifespan of stem cells after injection and provides an oxygen-rich atmosphere for the body to function at optimum levels.

Nerve Growth Factor (NGF)

Nerve growth factor (NGF) is a member of the neurotrophic factor (neurotrophin, NTFS) family, which can prevent the death of nerve cells and has many features of typical neurotransmitter molecules. NGF plays an important role in the development and growth of nerve cells. NGF is synthesized and secreted by tissues (corneal epithelial, endothelial, and corneal stromal cells), and it can be up-taken by sympathetic or sensory nerve endings and then transported to be stored in neuronal cell bodies where it can promote the growth and differentiation of nerve cells.NGF can exert neurotrophic effects on injured nerves and promote neurogenesis (the process of generating neurons from stem cells) that is closely related to the development and functional maintenance and repair of the central nervous system. It is also capable of promoting the regeneration of injured neurons in the peripheral nervous system, improving the pathology of neurons and protecting the nerves against hypoxia (lack of oxygen)/ischemia (lack of blood supply).

Nutrition Therapy

Occupational Therapy

Occupational therapy interventions focus on adapting the environment, modifying the task and teaching the skill, in order to increase participation in and performance of daily activities, particularly those that are meaningful to the patient with physical, mental, or cognitive disorders. Our Occupational Therapists also focus much of their work on identifying and eliminating environmental barriers to independence and participation in daily activities, similar to everyday life.

Physiotherapy

Physical therapy or physiotherapy (often abbreviated to PT) is a physical medicine and rehabilitation specialty that, by using mechanical force and movements, remediates impairments and promotes mobility, function, and quality of life through examination, diagnosis, prognosis, and physical intervention. We combine our PT with stem cells for maximum physical rehabilitation improvements.

Transcranial Magnetic Stimulation

Research has shown that TMS can effectively treat symptoms of depression, anxiety, neurological pain, stroke, spinal cord injuries, autism and more. This procedure is very simple and noninvasive. During the procedure, a magnetic field generator or coil is placed near the head of the person receiving the treatment. The coil produces small electrical currents in the region of the brain just under the coil via electromagnetic induction. This electrical field causes a change in the transmembrane current of the neuron which leads to depolarization or hyperpolarization of the neuron and the firing of an action potential.

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Stem Cell Therapy for Alzheimer’s in South Africa

September 20th, 2017 10:45 pm

This information is intended for general information only and should not be considered as medical advice on the part of Health-Tourism.com. Any decision on medical treatments, after-care or recovery should be done solely upon proper consultation and advice of a qualified physician.

What is Alzheimers disease?

This is a complex disease which affects brain nerve cells. It is the most common cause of dementia and effective treatment is very difficult.

What causes Alzheimers is still unclear. However, researchers have found out that there is an abnormal buildup of certain proteins in the brains of Alzheimers patients. Amyloid-beta is an example of one such protein. It clumps together to form plaques. Tau is another example, and it gets twisted into protein tangles.

Scientists have a theory that the plaques prevent proper communication of the brain nerve cells. The tangles make it hard for the nerve cells to get the nutrients they require. As the disease progresses, the nerve cells begin to die. Because of this, Alzheimers is a neurodegenerative disease.

Currently, Alzheimers disease has no cure. Medications are used to temporarily alleviate the symptoms by improving the ability to manage regular activities or enhancing memory. Most of these medications are cholinesterase inhibitors and they are used to prevent the breakdown of acetylcholine (a natural substance in the brain), which carries the signals between the neurons.

These are cells that can multiply and increase themselves (self-renew). In addition, they can develop and transform into different types of specialist cells which can carry out a specific function.

Yes, stem cell therapy can be done severally. Current research indicates the strong possibility of a cumulative effect from multiple therapies.

After the stem cell therapy, the stem cells have to make their way into the area in need of repair and then have their effect. This process takes time and usually takes several weeks or months to see the desired effect.

Currently, no proven and effective stem cell treatment for this disease is available. However, research is underway which utilizes stem cell technology to investigate the causes and effects of the disease. It is expected that their findings will play a crucial role in finding new drugs and cell-based therapies in the future. Stem cell therapy may help Alzheimers patients who do not respond to drug treatment, want to limit their reliance on medication or want to try stem cell therapy before drug treatment. Even if healthy, neural stem cells are available and can be safely transplanted, they would have to achieve therapeutic benefits by:

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New therapy could protect diabetic bones – Science Magazine

September 7th, 2017 11:47 pm

A new therapy changes the balance of osteoblasts (pictured here) and fat cells in the bone marrow, leading to stronger bones.

Science Picture Co/Science Source

By Emma YasinskiSep. 5, 2017 , 2:59 PM

A drug that can reverse diabetes and obesity in mice may have an unexpected benefit: strengthening bones. Experiments with a compound called TNP (2,4,6-trinitrophenol, which is also known as picric acid), which researchers often use to study obesity and diabetes, show that in mice the therapy can promote the formation of new bone. Thats in contrast to many diabetes drugs currently in wide use that leave patients bones weaker. If TNP has similar effects in humans, it may even be able to stimulate bone growth after fractures or prevent bone loss due to aging or disuse.

As more and more patients successfully manage diabetes with drugs that increase their insulin sensitivity, doctors and researchers have observed a serious problem: Thedrugs seem to decrease the activity of cells that produce bone, leaving patients prone to fractures and osteoporosis.

There are millions and millions of people that have osteoporosis [with or without diabetes], and it's not something we can cure, says Sean Morrison, a stem cell researcher at University of Texas Southwestern in Dallas. We need new agents that promote bone formation.

Morrison and his colleagues have shown that a high-fat diet causes mice to develop bones that contain more fat and less bone. The diet increased the levels of leptina hormone produced by fat cells that usually signals satiety in the brainin the bone marrow, which promoted the development of fat cells instead of bone cells. That suggests that nutrition has a direct effect on the balance of bone and fat in the bone marrow.

After reading Morrisons work, Siddaraju Boregowda, a stem cell researcher at the Scripps Research Institute in Jupiter, Florida, was reminded of genetically altered mice that dont gain body fat or develop diabetes, even when fed high-fat diets. He and his boss, stem cell researcher Donald Phinney, wondered whetherthose mice were also protected from the fattening of the bone marrow that accompanies a high-fat diet.

They contacted Anutosh Chakraborty, a molecular biologist who was studying such mice down the hall at Scripps at the time. The animals lack the gene for an enzyme called inositol hexakisphosphate kinase 1 (IP6K1), which is known to play a role in fat accumulation and insulin sensitivity. The scientists suspected that the lost enzyme might affect the animals' mesenchymal stem cells (MSCs)stem cells found in the bone marrow that are capable of developing into both thebone cells and fat cells that make up our skeletons. If too many fat cells develop, they take the place of bone cells, weakening the bone.

The researchers fed genetically altered and normal mice a high-fat diet for 8weeks. Not only did the genetically altered mice develop fewer fat cells than their normal counterparts, but their production of bone cells was higher than that of the normal mice, the team reported last month in Stem Cells.

The scientists then set out to see whetherthey could use a drug to achieve the same effect in normal mice. For 8weeks, they fed normal mice a high-fat diet and gave them daily injections of either TNP, a well-known IP6K1 inhibitor, or a placebo. When they analyzed the animals bones and marrow, they found that mice that had received TNP had significantly more bone cells, fewer fat cells, and greater overall bone area. The IP6K1 inhibitor apparently protected the mice from the detrimental effects of the high-fat diet.

The study provided thesurprising result that one new therapy currently being explored to lower insulin resistance promotes, rather than decreases, the formation of bone in mice, says DarwinProckop,a stem cell researcher at Texas A&M College of Medicine in Temple, who was not involved in the work.

The researchers still need to figure out how to deliver TNPs effects only to MSCs, instead of the entire body, given that it sometimes blocks other enzymes along with IP6K1. Inhibition of IP6K1 is a promising target for patients with both diabetes and obesity, Boregowda says. He says he and his colleagues are now enthusiastic about testing their findings in a wide range of bone-related diseases and disorders. It might even help heal broken bones, he speculates.

Phinney, on the other hand, is aiming even higher. He wonders whetherthe therapy could also be useful for space travel, because bones are especially vulnerable to deterioration in zero gravity. Its a whole new field of science and drug discovery.

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Stem Cell Therapy Expands Beyond Chronic Pain – WBAY

September 7th, 2017 11:47 pm

APPLETON, Wisc. (WBAY) As stem cell therapy grows in popularity in Northeast Wisconsin, treatment is expanding beyond chronic pain in the knees, hips, back and shoulders.

A Green Bay man battling lung disease says stem cell therapy saved his life.

Ken Schiller has lived on oxygen for the past 12 years while suffering from COPD, emphysema and Agent Orange.

"Tried to get a lung transplant and they told me well, can't do it, you're too old," says Schiller.

Five years ago, doctors gave Schiller four years to live.

But now he's breathing a sigh of relief.

"I couldn't walk 15-feet nine months ago without stopping to rest for 3-5 minutes, now I can walk through the grocery store, can walk out of this building to the car, I don't have a big problem," says Schiller.

Schiller turned to stem cell therapy at Optimal Stem Cell & Wellness Institute in Appleton.

"Now we've really seen incredible results with lung disease, COPD, pulmonary fibrosis, emphysema, these patients have nowhere else to go," says Dr. Michael Johnson who runs the clinic.

Dr. Johnson says patients like Schiller begin with a platelet rich plasma treatment, followed by stem cell treatment using stem cells from their own body fat.

"We draw off the fat, adipose, spin it down, draw off the stem cells and IV it back into them, after one round of stem cell therapy they're already doing better, it usually takes two or three for severe cases," says Dr. Johnson.

Schiller just underwent his third treatment and says he has a new lease on life.

"Two weeks ago we went to Laughlin, Nevada for four days, took a plane and came back, I thought those days were over, but they're not," says Schiller.

While stem cell therapy is still not FDA approved, or covered by insurance, Dr. Johnson says his office is fielding around 100 calls a week.

"This is the future," says Dr. Johnson.

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Pathway to Solve "Aging Population Syndrome", New Hope Has Been Delivered at TEDx Event – Markets Insider

September 7th, 2017 11:47 pm

CHENGDU, China, Sept. 7, 2017 /PRNewswire/ -- Aging and related diseases are problems we have to face. Recently, Dr. Y. James Kang, CEO/CSO of Revotek and a pathfinder in Regenerative Medicine, delivered a talk entitled "Transforming Disease-based Medication to Personalized Healthcare"at theTEDx event in Chengdu, China. He unveiled techniques that would improve the quality of life for 2 billion people worldwide.

Aging Population Syndrome and Disease-based Medication

Although it is not recognized, people who are over 60 years oldhave a lower quality oflife. This sounds rare but is really true. "Let me tell you what I heard from them, 'my doctor told me I need seven stents in my heart, but now I only put a couple and wait for a while to put them all,' and then they will talk about how to save money for future disease treatment," said Dr. Kang, "I call this aging population syndrome."

The syndrome results from the disease-based medication, or standard end-stage medication. Dr. Kang further explained, "A man, whose coronary arteries are 30% blocked with atherosclerosis plaque, might only be suggested by his doctor use bypass or vascular stents to reopen the vessel conduit when the plague further grows to the point leading to life threatening problem. Until then, he could take some statin drugs to slow down, but not to stop the plaque growth. This is disease-based medication." It is widely applied in today's medical practice but did not match well with patients' personalized problems.

Personalized Healthcare

Instead of spending rest of our life in drug-keeping, living a quality-maintained healthy life is our ultimate goal. The personalized healthcare is totally different from disease-based medication. It advocates solving personalized problems at an early stage to prevent the disease from deteriorating. Hence, transforming disease-based medication to personalized healthcare is highly demanded and closely related to our lives.

Regenerative medicine, the core of personalized healthcare, is capable of recovering the function of failing organs through integrated approaches including stem cells whichnaturally occur/stored in the human body and arecapable of repairing injured organs. When a body is injured, the injured tissue sends out signals, then the repair materials (stem cells) would respond and be recruited to the injury site for repair. Stem cells, the essence of personalized medicine, however,have not beenwell recognized until now.

DEVELOR

Stem cells are well known to almost everyone. However, their approved clinical applications are rare. Rather than inducing stem cells to a desired cell type before its induction into a patient,Dr. Kang's team created a brand-new approach of utilizing the stem cells, called "Destination-Engaged Vector Evolving Lineage Organ Regeneration (DEVELOR)". In brief, the core concept is to firstly maintain the stemness of stem cells during the culturing and proliferation procedures, and deliver anadequate number of cells to the injury site, which would orchestrate the behavior of stem cells by secreting regenerative signals.

How to use DEVELOR to repair the damaged organs? Dr. Kang's team isolated mesenchymal stem cells from 5 g fat tissue of rhesus monkeys, cultured and prepared to "Biosynsphere", a new type of bio-ink. Then, the bio-ink was stacked through the 3D bioprinter and covered with prosthetic vascular graft to form hybrid vascular graft, which was used to replace the susceptible sites of atherosclerosis, the abdominal aorta of donor monkey. One month post the surgery, the graft was integrated with the monkey's own abdominal aorta, and the structure and function of whichwere identical. Apart from this application, DEVELORhas also beenapplied to damaged organs with scar tissue, presented by Dr. Kang in his TEDx talk.

Dr. Kang's team simply develop a technique to rejuvenate the self-repair process which is orchestrated by the injured site itself. With this approach, disease-based medication could be transformed to personalized healthcare through regenerative medicine. Dr. Kang's team offered novel solutions to the present and future of aging and disease problems.

For more info, contact: rel="nofollow">contact@revotekco.cn

Related Links: https://www.youtube.com/watch?v=26ioUypNIKshttp://v.youku.com/v_show/id_XMjk3NDAxMTcxMg==.html?spm=a2h0k.8191407.0.0&from=s1.8-1-1.2

View original content with multimedia:http://www.prnewswire.com/news-releases/pathway-to-solve-aging-population-syndrome-new-hope-has-been-delivered-at-tedx-event-300515420.html

SOURCE Sichuan Revotek Co.,Ltd

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‘Unscrupulous’ stem cell clinics targeted in FDA crackdown – Genetic Literacy Project

September 7th, 2017 11:47 pm

Denise Grady & Sheila Kaplan | September 7, 2017 | New York Times

TheFood and Drug Administrationannounced a crackdown on dangerousstem cellclinicswhile at the same time pledging to ease the path to approval for companies and doctors with legitimate treatments in the growing field.

The agency reported actions against two large stem cell clinics and a biotech company, saying that it was critical to shut down unscrupulous actors

Federal marshals seized 500 doses of live Vaccinia virus vaccine forsmallpoxbelonging to StemImmune Inc., a San Diego firm that develops stem cell-based immunotherapies forcancer. The raid came after the F.D.A. learned that the vaccine was being used to create an unapproved stem cell product, a combination of excess amounts of vaccine and stem cells derived from body fat, which was then administered to cancer patients with potentially compromised immune systems.

StemImmune obtained at least some of the vaccine from the Centers for Disease Control and Prevention, according to Thomas Skinner, a C.D.C. spokesman.

Those enterprises put the entire field at risk, Dr. Gottlieb said. Products that are reliably and carefully developed will be harder to advance if bad actors are able to make hollow claims and market unsafe science.

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion, and analysis. Read full, original post:F.D.A. Cracks Down on Unscrupulous Stem Cell Clinics

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Curved substrates restrict spreading and induce differentiation of stem cells – Phys.Org

September 7th, 2017 11:47 pm

Credit: Biotechnology Journal

An invention by Florida Institute of Technology's Shengyuan Yang was found to naturally narrow the spreading of stem cells and has the potential to induce and regulate their differentiation.

Using Yang's patented and patent-pending technology, stem cells were grown on microscopic glass balls immobilized in a gel medium. Unlike the well-spread stem cells grown on a two-dimensional surface, the stem cells on the glass balls were almost uniformly spindle-shaped . More interestingly, this surface-curvature-induced-restriction in cell spreading also induced the differentiation of the stem cells.

These findings imply that the curvature of a substrate, as provided by the glass balls, may be utilized and tuned for cell and tissue engineering.

The research was recently published in Biotechnology Journal.

Yang's team used glass balls with diameters ranging from 5 m to 4 mm. They found that the minimum diameter of a glass ball on which a human mesenchymal stem cell (hMSC) can attach and spread is 500 m. Their gene expression experiments revealed that the hMSCs growing on the glass balls with diameters of 1.1 mm and below were differentiating into fat cells without the addition of any differentiation induction media.

This means that surface curvatures of a substrate could potentially be designed and optimized to achieve or change a specific cell shape and function. And, due to the different sensitivities of different cell types to substrate curvatures, the particular curvature of a growth environment, such as glass balls of various sizes, may also be used to construct cell-sorting devices.

Based on the experimental findings, Yang has filed three patents to cover the applications of the concept of substrate curvature in sorting cells, in guiding stem cell differentiation, in directing cell attachment and spreading, and in inducing isotropic spreading of cells.

Some past studies have shown the role of geometrical cues in influencing the differentiations of stem cells on two-dimensional surfaces, but to date, the effects of substrates with defined-curvatures on the behaviors of stem cells are still missing. Yang said studies on the cellular responses to substrate curvature are necessary and critical for understanding the cellular behaviors in three-dimensional micromechanical environments and for designing effective and efficient three-dimensional micromechanical environments to control cell and tissue developments. With their unique class of curvature-defined substrates, micro glass ball embedded gels are able to systematically investigate the effects of substrate curvature on the behaviors of stem cells.

With this promising first published report, Yang's group will continue to systematically investigate the effects of substrate curvature on the behaviors of stem cells.

Explore further: Professor publishes on first-ever imaging of cells growing on spherical surfaces

More information: Sang Joo Lee et al, Substrate Curvature Restricts Spreading and Induces Differentiation of Human Mesenchymal Stem Cells, Biotechnology Journal (2017). DOI: 10.1002/biot.201700360

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Buy bayer levitra online – Can you take levitra with food – The Postcolonialist

September 7th, 2017 11:46 pm

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Health-Care Issues Remain – The Central New York Business Journal

September 7th, 2017 11:46 pm

Nobody knew that health care could be so complicated. President Donald Trump

I was shocked by the quote above from our president, who made thisstatement in February 2017, soon after being inaugurated. As you all know, this statement was followed by six months of political debate over the repeal and replacement of Obamacare, also known as the Affordable Care Act. Contrary to the presidents statement, virtually anyone that has any connection to the U.S. health-care system knows that it is extraordinarily complicated. Medical professionals, health-system employees, patients, suppliers, vendors, and the majority of the citizenry would clearly disagree with the presidents statement that nobody knew.

This past six months, I have debated with myself whether a column related to health-care reform would be of value. After considerable thought and reflection, I realized that the following column, originally published in the Rochester Business Journal in January 2005, was as relevant today as it was then. As you read the following, it will be clear that the health-care debate has been a subject in political football since the enactment of the Medicare and Medicaid programs in 1965. As you read, remember that I did not have to change one word of what I published in the column some 12 years ago.

January 2005 column

Our health-care cost crisis is of our own making. Before launching into my health-care solutions agenda, please be advised that my opinions are predicated on a foundation of irrefutable assumptions.

All people are created equalNo human being is immortalWe live in a capitalist, not socialist, economyEvery individual has a right to access health-care servicesSocioeconomic factors create inequality in wealth distributionHealth-care cost is of legitimate concernThe vocal majority rules in health-care decision-makingThere is no such thing as unanimous support for health-care policy decisions

With these baseline assumptions, allow me to articulate a 10-point program for improving the cost-effectiveness of our communitys health-care system. Even though I must admit a fiscal bias due to my profession, the quality of health care is of equal importance in addressing these potential solutions. Also, I never intend to run for political office, and these opinions will ensure that I could never be elected.

With all due respect to myriad interest groups and health-care lobbies, here is Archibalds Top 10 list, in David Letterman format, with no humor intended:

10. Controllable behaviors that negatively impact an individuals health should be reflected as an increased cost in insurance premiums. If I smoke two packs a day, I should pay more. Abuse of controllable behaviors costs more in life and automobile insurance, why not health care? Tobacco and alcohol companies, beware.

9. Tort reform and caps on personal injury, pain and suffering awards are a legislative requirement. Maine took the first step in what I hope will be a trend in limiting awards in the litigation area. One of the platform issues of the new administration that I agree with is tort reform.

8. Successful reform of the health-care legal system should allow providers to immediately reduce costs associated with defensive medicine. The costs of unnecessary visits, tests, and procedures ordered by service providers to reduce the potential risk of litigation total billions of dollars each year. And malpractice-insurance-premium decreases will be an ancillary benefit.

7. Reintroduce the consumers wallet into health-care access and decision-making. If an individual wants to access health-care services, there should be a direct cost to the consumer, subject to income limitations. The recent adoption of health-savings accounts as an incentive for employers and employees to take control of escalating health-care costs is a paradigm shift in our governments attitude towards health care. Health-care costs are virtually invisible to consumers, and a Wegmans vs. Tops price comparison would certainly affect costs. If you want proof, look at the declining cost trends for Lasik surgery procedures.

6. Reduce the level of administrative and regulatory compliance costs in health care. Depending upon the study, costs in these areas consume up to 26 percent of every health-care dollar. The potential savings are enormous.

5. Technology advancement is wonderful and our nations research industry is the finest in the world. However, technology advances frequently increase costs through obsolescence of existing equipment and the incremental cost to providers of adding the new technology. This area may be one of the most difficult to address since any control mechanism that limits new technology must be balanced with appropriate incentives for research initiatives.

4. Controls over the drug manufacturers and pharmaceutical suppliers must be established. The efficacy of drug therapies must be assessed. Blatant and excessive advertising by the pharmaceutical industry to a public that is largely not responsible for the drug cost must be reined in. The final three items on my list are the most controversial of all. If I havent lost your vote yet, I am confident that the Big Three will push you to pull another lever.

3. Health-care capacity must be addressed through a local community effort. The debate is not about either competition or cooperation but, as Deion Sanders once said, I want both. Health-care delivery in this country is largely controlled by local communities. Competition among service providers is an essential element of health-care cost and quality in every community. Leadership without bias is a necessity for success in this area.

2. Establishing standards for patients expectations of their right to access health care, both basic and advanced, is a necessity. The research discoveries on the near horizon from genetic mapping will create new opportunities and make obsolete existing equipment and facilities. Bioethical debate must address the essential question of, Who is entitled to what and at what cost?

1. End-of-life care must be addressed. We are making progress in this area with health-care proxies, palliative-care initiatives, and other planning processes. However, its staggering to know that the majority of your lifetime health-care costs will be spent in the last year of your life.

Health-care spending is approaching 15 percent of our gross domestic product. The baby boom generation, of which I am a proud member, is beginning to retire. The health-care issues we face as a community and a country are overwhelming.

As CEO of Excellus, the dominant insurer in our community, David Kleins piece in the Dec. 19, 2004, edition of the daily newspaper was of interest. He stated: A healthier community is fostered when its business leaders, physicians and other health service providers are included in the dialogue and when these professionals work in an environment that has its major health service and financing organizations working more cooperatively and with a focus on community benefit. While this quote is a mouthful of words, action in support of this philosophy is what is needed.

Each of us must look in the mirror. A realistic assessment of our mortality and myriad issues that must be addressed is imperative. True innovation and industry reform can be a reality in health care.

Ignoring the debate and compromise necessary will only make matters worse.

The only modification to the 2005 column is that health-care costs now represent 18 percent of our gross domestic product. It is truly fascinating to me how little has been accomplished in the past 12 years. We can only hope that the future will bring rational reforms that address each of the major issues discussed in my 2005 column.

Gerald J. Archibald, CPA, is a partner in charge of the management advisory services at The Bonadio Group. Contact him at (585) 381-1000, or email: garchibald@bonadio.com

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Spain OKs TiGenix’s bigger cell therapy plant as firm preps for Cx601 – BioPharma-Reporter.com

September 7th, 2017 11:45 pm

Spain has licensed TiGenix NV's expanded Madrid plant paving the way for a potential European launch of Cx601, its cell therapy forthe Crohn's disease complications.

Belgium-based TiGenix announced it received the Spanish Medicines Agency (AEMPS) license this week, explaining the Madrid plant will provide capacity for production of its portfolio of cell therapies including the candidate cell therapy Cx601.

Chief technical officer Wilfried Dalemans said: We have now significantly increased our manufacturing capacity, a key step in the preparation for commercialization of Cx601 in Europe and in the further development of our pipeline.

Cx601 has been accepted for review by the European Medicines Agency (EMA) and Swissmedic, which began reviewing TiGenix dossier in June.

At the time the firm told us Takeda will take over responsibility for making the cell therapy from 2021 but did not provide additional details.

Manufacturing expansion

Cx601 is made from stem cells taken from donor adipose tissue. It is being developed for the treatment of complex perianal fistulas in patients with Crohns disease patients who do not otherwise respond to standard therapies.

The therapy is madein a 2-dimensional cell culture.

TiGenix expanded the Madrid facility with support from Japanese drug firm Takeda, which licensed rights to commercialize Cx601 outside the US.

In the US, TiGenix has hired Lonza to make Cx601.

In February, the Belgian biotech said Lonza is transferring manufacturing technologies to its facilities in the US, adding that the Swiss contractor is poised to begin making the product for clinical trials.

A TiGenix spokeswoman told us "Lonza will manufacture material for the global Phase 3 trial of Cx601 in the US at Lonzas cell therapy production facility in Walkersville, Maryland (US), and the GMP facility will support the potential initial European commercial roll out of Cx601."

She added that: "The expanded facility will also provide capacity for the manufacturing of other pipeline products under development by TiGenix, including Cx611, currently undergoing a Phase I/II trial in severe sepsis."

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Norwich to Haiti – Connecticut Magazine

September 7th, 2017 11:44 pm

Dr. Royneld Bourdeau, Haitian Health Foundation medical director

It has become a trenchant criticism of many non-government organizations in the international aid sphere in recent decades: bloated administrative budgets and overhead costs mean that most aid money gets funneled into salaries and associated perks. Many NGOs working in the developing world have their U.S. headquarters close to the centers of power, in plush office spaces in New York or Washington.

Not so for the Haitian Health Foundation. A humble, wood-paneled office on the banks of the Yantic River in Norwich works just as well. As it has since the early 1980s, when the organization was founded by local orthodontist Jeremiah Lowney, the HHF does an immense amount of work across a broad spectrum of areas. The foundation serves a predominantly rural area of southwest Haiti known as the GrandAnse, centered around the headquarters in the city of Jrmie. The primary work of HHF is in immediate health care needs, which are sorely underfunded in Haiti.

The foundation operates a full-service outpatient clinic in Jrmie, as well as a maternal waiting room, and offers a treatment for a particular type of protein malnourishment called kwashiorkor, which is common in the developing world. Out in the mountains to Jrmies south, HHF employs a small army of health agents at community clinics across just over 100 villages.

While health care is the backbone of the work done by HHF, its mission spills into what one might call a holistic approach to health and health care. For the HHF, decent housing, adequate food and sanitation systems are part of health care, part of what keeps people out of medical facilities. Respiratory infections, asthma and poor mental health are just some of the ailments that can result from poor housing. In coordination with Rotary clubs around New England, the HHF has also been engaged in the distribution of animals since the 1980s: first pigs, then chickens, and now goats to families throughout the GrandAnse. Two eggs a week is enough to keep a child from falling into kwashiorkor, Lowney says.

Part of that holistic approach to medicine, perhaps, results from Dr. Lowneys background in orthodontics. Dentistry, Lowney explains, is more oriented toward preventative medicine than most other specialties. He says that most medicine, by and large, still isnt that preventative, you know? You go in when youre sick. With dentistry you are always encouraged to go twice a year for a dental exam, get your teeth cleaned, that kind of thing. The HHF used to operate out of Lowneys orthodontics practice, still located across Sherman Street from the current offices.

Few countries have as proud-while-tragic a history as Haiti. It was the first free black republic in the world, winning independence from France in 1804 after the worlds first successful slave revolt. Almost immediately, outside forces sought to cripple the young country. In 1825, with warships at the ready, King Charles X of France demanded Haiti pay a debt to the former slave owners from whom the people of Haiti had freed themselves. The debt France demanded was 10 times Haitis annual revenue. The Haitian state was indebted into the 1940s. The nearly 30-year dictatorship of father and son Francois and Jean-Claude Duvalier was characterized by the hoarding of money and political repression. A pair of military coups in 1991 and 2004 added to political instability, and the 2010 earthquake and 2016 hurricane have led to an outbreak of disease in the country. Hurricane Matthew in October 2016 devastated the GrandAnse, and the HHF was fortunate not to have lost any colleagues. Since then, the organization has distributed some 150 tons of food in the region.

Lowney made his first trip to Haiti in 1981, after being asked by Daniel Patrick Reilly, the bishop of Norwich, to heed the call of Pope John Paul II for those in rich countries to reach out to those in poor countries. After repeated trips to Haiti throughout the early 1980s, Lowney came into contact with the sisters from Mother Teresas Missionaries of Charity, who eventually asked him to relocate his work to the GrandAnse, where medical services were lacking. Lowney founded HHF in 1985 with his wife, Virginia, who is also still involved in coordinating the Save a Family program, in which donors can sponsor individual families for a variety of needs, from housing to animals to sanitation.

While Lowney is still intimately involved in the organization, his daughter Marilyn now serves as the executive director. The organization has some 200 employees in Haiti, the vast majority of them Haitian. HHFs country director, Nadesha Mijoba, explained the organizations governing philosophy in a Skype interview from Jrmie. Were not here to tell the community how they should run their affairs. Were not here to preach to them. Rather, we work with them, she says.

There are many ways to help the Haitian Health Foundation. Go to haitianhealthfoundation.org/donate to learn how.

If you have an organization with an event that youd like us to consider for the Community page, please send the details to mmurphy@connecticutmag.com.

If you have an organization with an event that youd like us to consider for the Community page, please send the details to mmurphy@connecticutmag.com.

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