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This is by no means an easy topic to write a newspaper article about. In fact, I thought for many months about writing a column on this subject. It is receiving increasing media coverage, and with the request from fellow veterinarians in town, I think it is an appropriate time to address it.

It involves the veterinary professions increased risk for compassion fatigue, burnout and suicide.

A study of 10,000 veterinarians by the Centers for Disease Control in 2014 found one in six veterinarians have contemplated suicide.

In fact, veterinary professionals are four times more likely to commit suicide than the average citizen.

The veterinary profession also has the highest risk of suicide out of all of the medical professions.

This statistic is not reserved solely for general practitioners.

In the last few years the profession has lost notable behaviorists, surgeons, specialists, technicians and general practitioners to this mental illness.

What makes veterinary professionals more likely to experience compassion fatigue and then commit suicide?

The answer is complex and specific to each individual person (as is all mental illness), yet I believe there are certain key elements across the profession that make us more at risk than the general population.

The veterinary profession attracts professionals who are ambitious, driven, intelligent, compassionate, empathetic and hardworking, with an unwavering commitment to veterinary medicine.

These traits that help us become great doctors and practitioners can also be to our detriment.

It is all too common for veterinarians to take it personally if a case cannot be easily solved, a surgery does not go as planned or a patient cannot be saved.

After all, we are not used to getting Bs in school, let alone thinking we are failing a life!

It is very common to take work home, to dwell on it and retreat from loved ones who seem to not be able to relate. A vicious cycle can start when doubt, depression and isolation set in.

As well, the veterinary profession experiences more incidents of trauma than the general population, but also when compared to the other medical professions.

Our goal as a profession is to be a voice for the voiceless. However, that does not mean everything can be saved and for many of us, that is a very difficult pill to swallow.

While I personally believe euthanasia is one of the most humane acts we can perform as veterinarians, it does not mean we do not feel every time we push the syringe. It often means the exact opposite: We often feel, and perhaps too deeply.

Another form of trauma experienced by veterinary professionals that is unique to the profession is that decisions affecting diagnosis, treatment and quality of life of a patient are dependent upon an owners financial capabilities. Often compounding this trauma is an owner upset that we cannot perform services at no cost.

Using this against us is a form of emotional bullying.

If we could save everything for free we would; but if we took financial responsibility for every pet that needed it, we would burn out even faster.

We have to balance patient care for ALL patients, care for ourselves, care for our staff and care for the clinic as a business.

Our commitment to the profession also means younger professionals are incurring more debt than previous generations.

Our average starting salary is $65,000, whereas in 2016, more than 20 percent of veterinary graduates finished school with more than $200,000 in debt.

Financial advisers recommend a debt-to-income ratio of 1.5-2 to 1. Our ratio is often two to four times higher!

Imagine the deep love we must feel for our profession when we knowingly choose to devote our lives to the voiceless, despite the financial burden it puts on us.

It is then understandable the rebuff we feel when clients state we are in this for the money, or that we dont love their pet enough.

It is often this statement that furthers many veterinary professionals isolation and depression.

So how can we help this crisis? First, I strongly believe in self-care emotionally, physically and spiritually.

There should never be shame associated with seeking assistance from a professional.

Second, I think the veterinary profession and owners need to re-establish a mutual compassion for each other.

Communication from all parties should be done with grace and kindness.

It is imperative we understand we are all humans seeking to create a healthy, long-lasting relationship with our pets and the world around us.

Danielle Carey, DVM, is an associate veterinarian who practices mixed-animal veterinary medicine at the Animal Clinic of Walla Walla. Contact her at 509-525-6111.

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Veterinarians also susceptible to workplace, financial stressors - Walla Walla Union-Bulletin

A statewide college recently was recognized for its affordable, high-quality programs that support career development skills in production agriculture, agribusiness and technical trades, a high priority throughout Nebraska.

The national business magazine Forbes recently placed the Nebraska College of Technical Agriculture at Curtis, one of the jewels in the University of Nebraska system, on its list of Top 30 Trade Schools in the United States.

NCTA Dean Ron Rosati said the colleges performance was based on academic quality, affordability and graduate earnings.

NCTA is gaining notice for its expanded programs in welding, irrigation technology, precision agriculture, veterinary science, animal science and experiential learning.

I have enjoyed serving on the NCTA Deans Advisory Council for 16 years, and witnessing tremendous expansion in programs and opportunities. I also have a vested interest as a tuition-providing parent of two children who attended NCTA.

Traditionally, the college provides a two-year associate degree program. More recently, it added two-semester certificates for welding and irrigation technicians.

Meanwhile, transfer options to four-year institutions have never been better, including with UNLs College of Agricultural Sciences and Natural Resources.

Animal Science and Agricultural Education Division Chairman Doug Smith reports a record number (16) of NCTAs May graduates plan to complete four-year degrees, including 13 who will start fall classes at CASNR. Two are UNL-bound in veterinary medicine or technology, and there are three each in agronomy, animal science, ag business and ag education.

The two-year NCTA Agricultural Education Program helps to fill a void for FFA-agricultural education programs. Smith says three of his NCTA graduates will be teaching in Nebraska high schools this fall.

Additionally, NCTA and CASNR recently announced a bachelor of applied science program that allows NCTA graduates to take online classes through CASNR with oversight by NCTA on campus or by commuting to Curtis.

This initiative allows students to work at farms, ranches or in other agricultural careers in central or western Nebraska without setting foot in Lincoln. What an outstanding opportunity!

Certified technicians are graduating from NCTA with majors in veterinary technology, irrigation technology and welding. Nebraska has the greatest number of center pivot irrigation manufacturers and largest number of irrigated acres, so its industries have strong demand for a trained workforce in electricity, welding, and ag equipment maintenance and repairs.

NCTA launched irrigation technician training in 2013. By 2016, the college had partnered with several ag cooperatives and industries to develop an ag career track in Nebraska high schools to include classes in diversified agriculture and agricultural chemical applications.

The first two graduates of the dual-credit program at York High School this May earned NCTA certificates in agricultural chemical applications. One will enter NCTA in August with one year of college credits.

Agronomy professor Brad Ramsdale has been teaching students in agronomy and crop sciences for eight years, and established an award-winning crops judging team that repeated as national champion in 2017.

Ramsdale recently completed a two-week crops-agronomy summer program for honor students. Partnering with Educational Service Unit 11, he guided students at classes in Holdrege and a two-day camp at NCTA featuring its on-campus agronomy resources.

The day camps and dual-credit programs are among many NCTA developments in the past five years. Expanded programs include precision agriculture courses taught by Ramsdale and practical crop management courses in which students form teams to manage crops at the NCTA farm laboratory just north of the Curtis campus.

The teams decide on seeding rates, irrigation management, fertilizer applications, weed control measures, harvest management and equipment maintenance.

NCTAs ag equipment program was reinvigorated in 2013 and now includes an irrigation technology partnership with Reinke Manufacturing and a welding program that has produced its first student to be certified by the American Welding Society.

Instructor Dan Stehlik graduated from what was the University of Nebraska School of Technical Agriculture. The alum taught in Kansas ag education programs for 19 years before returning to the Curtis campus to teach ag equipment, welding and irrigation technician programs.

College alumni say they are pleased to see the welding program expand because of the high demand for welding technicians. Production enterprises also are seeking well-rounded employees with skills in crops, livestock, machinery or equipment maintenance and business.

Central Nebraska Public Power and Irrigation District has partnered with NCTA on several annual forums, including regular tours of the Central project through the Nebraska Water Balance Alliance.

NWBA members have had opportunities to mentor and interact with NCTA students at forums that bring irrigators, farm managers, educators, vendors and the public to the campus Nebraska Agriculture Industry Education Center.

The Natural Resources Conservation Service recently conducted internal training sessions and the Unicamerals Natural Resources Committee, chaired by District 44 state Sen. Dan Hughes of Venango, will have a public hearing at NCTA in the fall.

My involvement with NCTA and its predecessor go back to when the South Platte United Chambers of Commerce advocated for keeping the school open on behalf of Nebraska agriculture. SPUCC has continually voiced strong support for the college.

NCTA has been re-accredited regionally by the Higher Learning Commission. The veterinary technology program is re-accredited by the American Veterinary Medical Association.

As for affordability, fall tuition at NCTA is $127.50 per credit hour for all students, regardless of residency.

I look forward to seeing whats in store next for the hidden gem of a college in Curtis.

Tim Anderson is a public relations adviser to Holdrege-based Central Nebraska Public Power and Irrigation District.

Editors note: Mary Crawford, external relations coordinator for NCTA, provided some information for this column.

The rest is here:
NCTA is 'gem' for higher learning in state - Kearney Hub

Reaching immortality is still in the realm of science fiction. But using clues from our genes, scientists are one step closer to understanding why some of us live to be centenarians while others don't.

Using a specific set of genetic markers, scientists predicted with 77-percent accuracy whether someone would live to a very old age.

The findings do not mean that lifestyle factors, such as healthy diet and exercise, are not important for long life. Indeed, 23 percent of the time the genetic markers didn't predict longevity. So those long-lifers without the centenarian genes might have practiced healthy habits that allowed them to lead a longer life. [Learn more facts about centenarians]

But they do suggest our genes play an important role when it comes to living well past the average lifespan. With more research, one day people might be able to determine whether they have the genetic potential to become a centenarian.

Additionally, learning more about how centenarians ward off diseases, including dementia, heart disease and cancer, well into their elder years, might help the rest of us delay disease.

"I'm very hopeful that understanding how and why centenarians are able to do that will lead to strategies and therapies, including screening and figuring out who could be helped by whatever therapies [there] are down the road," study researcher Tom Perls, of Boston University School of Medicine, said in a press briefing Wednesday about the study.

The results will be published this week in an early online edition of the journal Science.

Longevity genetics

The researchers compared the genomes of 1,055 centenarians (average age of 103) with those of non-centenarian controls.

They identified differences in the genetic code, known as genetic variants or markers, that were common in centenarians but not in the average population.

Using a computer model, they found 150 of these markers could predict 77 percent of the time whether a person lived into their late 90s and beyond.

Additionally, they saw 90 percent of the centenarians could be categorized into one of 19 groups based on which genetic variants they had. In other words, each group had a distinguishing "genetic signature" made up of certain genetic markers.

Differences in these genetic signatures may relate to differences in the way extreme longevity manifests itself. For instance, some genetic signatures were associated with extremely old age (living 110 years or more), while others were associated with a late onset of diseases such as dementia.

So can someone live to old age without these markers? Perhaps. About 30 of the centenarians had almost none of the longevity associated markers. In these cases, extreme old age might be influenced by other markers that have yet to be identified, or by the subject's lifestyle.

The researchers were also curious if centenarians had fewer markers that are known to be linked with diseases. However, in this respect, they found little difference between the centenarians and the control group.

This might mean that centenarians owe their exceptional lifespan not to less "bad genes," but to the presence of "good genes" that override the harmful ones.

This results suggests "that what makes people live very long lives is not a lack of genetic predisposition to diseases, but rather an arrangement of longevity associated variants that may be protective, it may even cancel the negative effect of disease-associated variants," said study researcher Paola Sebastiani, of Boston University School of Public Health, who also spoke at the briefing.

Future outlook

The researchers caution that before a genetic test for longevity is developed, scientists need to have a better understanding of what kind of effect the information could have on society, such as in the context of health care.

They hope the study spurs additional research into these genetic markers and how they might biologically contribute to longevity.

"I think that we're quite a ways away still in understanding what pathways governed by these genes are involved, and how the interaction of these genes, not just with themselves, but with environmental factors, are all playing a role in this longevity puzzle," Perls said.

The study was funded by grants from the National Institute of Aging (NIA) and the National Heart Lung and Blood Institute (NHLBI) of the National Institutes of Health (NIH).

Excerpt from:
Longevity Genes Predict Whether You'll Live Past 100

The Hindu

Sharks could hold genetic secret to long life: Study The Hindu The genetic sequences helped the researchers understand whether the Greenland shark has evolved specific metabolic adaptations towards extreme longevity. They are now attempting to find the genes that hold the secret to why the sharks live so long.

More:
Sharks could hold genetic secret to long life: Study - The Hindu

In BriefResearchers have identified a single gene deletion in E. colibacteria that influence longevity in C. elegans worms. This pointsto the role of gut bacteria in life extension and points to thepossibility of a life-extending probiotic in the future.

Researchers at the Baylor College of Medicine have found the key to longevity in Caenorhabditis elegans (C. elegans) worms and maybe, someday, humans. The team noticed that genetically identical worms would occasionally live for much longer, and looked to their gut bacteria to find the answer. They discovered that a strain of E. coli with a single gene deletion might be the reason that its hosts lives were being significantly extended.

This study is one among a number of projects that focus on the influence of the microbiome the community of microbes which share the body of the host organism on longevity. Ultimately, the goal of this kind of research is to develop probiotics that could extend human life. Ive always studied the molecular genetics of aging, Meng Wang, one of the researchers who conducted the study, told The Atlantic. But before, we always looked at the host. This is my first attempt to understand the bacterias side.

Even in cases like this, where it seems fairly obvious that the microbiome is influencing longevity, parsing out the details of how and why this happens among a tremendous variety of chemicals and microbe species is extremely complex. The team, in this case, was successful because they simplified the question and focused on a single relationship.

Genetically engineering bacteria to support and improve human health and even to slow aging and turning it into a usable, life-extending probiotic wont be easy. It is extremely difficult to make bacteria colonize the gut in a stable manner, which is a primary challenge in this field. The team, in this case, is looking to the microbiome, because the organisms used would be relatively safe to use because they would originate in the gut.

Clearly, researchers dont know yet whether these discoveries will be able to be applied to people, though it seems promising. Despite the obvious differences between the tiny C. elegans worm and us, its biology is surprisingly similar; many treatments that work well in mice and primates also work in the worm. The team will begin experiments along these same lines with mice soon.

Other interesting and recent research hoping to stop or slow the march of time includes work with induced pluripotent stem (iPS) cells, antioxidants that target the mitochondria, and even somewhat strangework with cord blood. It seems very likely that we wont have a single solution offering immortality anytime soon, but instead a range of treatment options that help to incrementally hold back time. And, with an improving quality of life, this kind of life extension sounds promising.

Excerpt from:
This Study Could Help Extend the Human Lifespan - Futurism

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USA Today Network Zach Blanchard, WLBZ-TV, Bangor, Maine Published 8:13 a.m. ET July 7, 2017 | Updated 10:58 a.m. ET July 7, 2017

The perfect wine is less about taste buds and more about personality! Buzz60's Lindsey Granger is helping you find your perfect pairing. Buzz60

The birthday girl, Florence Bearse, center, takes a drink of wine during her 100th birthday party at Westgate Center for Rehabilitation & Alzheimer's Care in Bangor, Maine, on Thursday, July 6, 2017.(Photo: WLBZ-TV, Bangor, Maine)

BANGOR, Maine Known for her no-nonsense attitude and sense of humor, Florence Bearse celebrated her 100th birthday Thursday.

At her birthday party at the Westgate Center for Rehabilitation & Alzheimer's Care in Bangor, Maine, Bearse did not shy away from sharing her secret to long life: wine.

I like my wine. Don't take it away from me, she said.

More: 100-year-old never could use free-food-for-life gift

Originally from Massachusetts, Bearse said it did not take long to find the beauty of Maine.

I like my wine. Don't take it away from me.

"Maine is beautiful," she said. "I tell everybody, 'You want a trip? Go to Maine.' "

Bearse said she ran a restaurant in Lagrange, Maine, where she dedicated her life to serving others.

"The people have taken me I think. They understand me ... that I'm crazy," she joked.

More: Want to live past 100? Centenarians share their secrets

Bearse spent much of her time joking around during the party, which was complete with birthday cake, balloons and gifts.

She even had some advice for those looking to make it as far as she has:

"Don't take any baloney, Bearse said.

Follow Zach Blanchard on Twitter:@ZachBlanchard

More: McDonald's gives 100-year-old free food for life

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Knocking back a cold one each day could help keep your "good" cholesterol levels high. Video provided by Newsy Newslook

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A Spanish wine company called Gik is introducing the world to an electric blue wine. Mara Montalbano (@maramontalbano) has the details. Buzz60

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Read or Share this story: https://usat.ly/2tZnlt0

Originally posted here:
100-year-old woman's secret to longevity? Wine - USA TODAY

Bangor woman celebrates big 100

Zach Blanchard, WLBZ 1:48 PM. EDT July 07, 2017

BANGOR, Maine (NEWS CENTER) Florence Bearse celebrated her 100th birthday in Bangor Thursday.

Known for her no-nonsense attitude and sense of humor at the Westgate Center for Rehabilitation, Florence did not shy away from sharing her secret: wine.

I like my wine. Don't take it away from me, she said.

The event was complete with all the fixings, including birthday cake, balloons and gifts.

Bearse said she ran a restaurant in Lagrange where she dedicated her life to serving others.

"The people have taken me I think. They understand me. That I'm crazy, Bearse joked.

Originally from Massachusetts, she said it did not take long to find the beauty of Maine.

"Maine is beautiful. I tell everybody, You want a trip? Go to Maine, she said.

Florence spent much of her time joking around during the party, making faces and laughing.

She even had some advice for those looking to make it as far as she has:

"Don't take any bologna, Bearse said.

2017 WLBZ-TV

Read the original here:
Maine woman celebrates 100th birthday, says wine is secret to ... - WCSH-TV

751 0 Posted on Jul 07, 2017, 6 a.m.

Study reveals a correlation between higher childhood intelligence and lower risk of leading causes of death over ones lifetime.

Those who exhibited high intelligence in their childhood years have a reduced lifetime risk for the top causes of death like heart disease, respiratory disease, stroke, dementia and smoking-related cancers. This finding was recently published in The BMJ.

About the Study

A group of University of Edinburgh researchers sought to study the association between IQ scores gauged at 11 years-old and the top causes of death in people upwards of age 79.It is the largest study centered on reporting the causes of death throughout the course of life. The findings show that lifestyle, especially smoking tobacco, is a critically important factor in the effect of IQ on differences in lifespan. Prior studies showed that those with improved intelligence tended to live slightly longer than individuals with less intelligence. However, these studies were mainly based on information derived from male conscripts tracked to the mid-adulthood years.

The findings were derived from data from more than 33,000 men and over 32,000 women born in Scotland back in 1936. These individuals took a childhood intelligence exam at age 11. Their cause of death was identified up to December of 2015. Causes of death for these individuals ranged from stroke to heart disease, digestive disease, cancer, dementia and external causes like suicide or death resulting from an injury.

The Results

Once a number of different factors (age, socioeconomic status, sex) that had the potential to impact the results were accounted for, the research team determined that those whohad a higher childhood IQ score enjoyeda decreased risk of death until the age of 79. As an example, a high score on the childhood IQ test was tied to a 28 percent decrease in risk of death due to respiratory disease. A high score was associated with a 25 percent reduction in risk of death induced by coronary disease. Those who scored high on the childhood IQ test had a 24 percent reduction in risk of death stemming from a stroke.

Other important associations were found for deaths from dementia, digestive disease, injury and cancers related to smoking. There was no association between IQ score and death from cancers that did not relate to smoking.

Why the Study has Merit

Thoughthe study's authors identified study limitations that had the potential to introduce bias, the study is widely considered to be meritorious. The large population sample combined with the 68-year follow-up along with the adjustment for vitally important co-founders gives the study credence. Key associations were intact after additional adjustments for smoking as well as socioeconomic status. This suggests that such factors do not completely account for differences in mortality. Additional studies should consider measures of the cumulative load of these risk factors across the life course.

It can be concluded that childhood intelligence is strongly tied to causes of death that are dependent on previously identified risk factors. The study suggests smoking and its distribution across the socioeconomic spectrum is critically important. Yet it is undetermined if this study tells the whole story or if intelligence indicates something deeper. Perhaps there is a genetic basis to IQ's relation to lifespan.

More:
High IQ in Childhood Linked to Longevity - Anti Aging News

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Getting to grips with longevity - The Economist

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Financing longevity - The Economist

Greenland sharks are the longest living vertebrates on Earth. Photograph: Julius Nielsen

Greenland sharks, the longest living vertebrates on Earth, which can be found off the northern coast of Ireland, could hold the secret to long life, geneticists mapping their DNA have predicted.

The sharks, which live for up to 400 years, are believed to have unique genes that could help explain not only their remarkably long life span but also life expectancy in other vertebrates including humans.

Prof Kim Praebel of UiT, the Arctic University of Norway, described the sequencing of the DNA from Greenland sharks at a symposium of the University of Exeter this week. Many living Greenland sharks are so old that they pre-date the industrial revolution and the introduction of intensive commercial fishing.

With collaborators, Prof Praebel is searching for unique genes which could hold the secret to the sharks longevity.

They have obtained Greenland shark DNA from tiny clippings from the fin of sharks, which are caught on a line live, tagged and released.

The team has sequenced the full mitochondrial genome (complete DNA information) of almost 100 Greenland sharks, which includes individuals born in the 1750s.

The genetic sequences have helped them understand whether the Greenland shark has evolved specific metabolic adaptations towards extreme longevity, he said.

Their research that suggested the sharks may be up to 400 years old was published in the leading journal Science last year. They are now attempting to find the genes that hold the secret to why the sharks live so long.

They believe the Greenland sharks extreme life span makes it so unique that there is a case for giving it a special conservation status, he added.

This is the longest living vertebrate on the planet. Together with colleagues in Denmark, Greenland, USA, and China, we are currently sequencing its whole nuclear genome which will help us discover why the Greenland shark not only lives longer than other shark species but other vertebrates, he said. The results will help us understand more about the biology of this elusive species.

Its long-life genes could shed light on why all vertebrates have a limited life span, and what dictates the life expectancy of different species including humans, Prof Praebel told the Fisheries Society of the British Isles.

Greenland sharks do not seem to succumb to diseases that kill related species much earlier.

Little is known about the biology and genetics of the Greenland shark which is found in deep waters in the Atlantic ocean from Canada to Norway including north of Ireland and Britain. It is a member of the sleeper shark family that has existed for around 110 million years.

The oldest and largest Greenland shark at just over five meters analysed by the scientists was estimated to be 392 years, plus or minus 120 years, ie at least 272-years- old.

To determine when key indicator proteins were laid down, the scientists deployed radiocarbon dating a method that relies on determining within a material the levels of a type of carbon, known as carbon-14, that undergoes radioactive decay over time.

The DNA study has shed new light on its behaviour, and how it is related to other members of its species living thousands of kilometres away, Prof Praebel added.

Since the Greenland shark lives for hundreds of years, they also have enough time to migrate over long distances and our genetic results showed exactly that. Most of the individuals in our study were genetically similar to individuals caught thousands of kilometres away.

It is still not known where and how the Greenland shark reproduces, but it may prefer to mate in deep hidden fjords of the Arctic. With adult female Greenland sharks known hit sexual maturity only once they reach more than four metres in length, the scientists found that females have to clock up an age of around 150 years before they can produce young.

Equally, there are still far from understanding how and why this elusive species, which feeds on seals and fish, lives so much longer than other sharks and vertebrate species. Other shark species living in the same regions as the Greenland shark live between 30 and 50 years.

Tissues, bones, and genetic data from the shark will also help measure the impact of climate change on the population, when and how contaminants and chemical pollution from industry began to affect the oceans, and the extent to which commercial fishing over hundreds of years has affected the shark population.

The longest living vertebrate species on the planet has formed several populations in the Atlantic Ocean. This is important to know, so we can develop appropriate conservation actions, he said.

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Greenland sharks beginning to shed their secrets on longevity - Irish Times

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NAS Releases Final Report on Preparing for Future Products of Biotechnology - JD Supra (press release)

Investors in Puma Biotechnology, Inc. (PBYI - Free Report) need to pay close attention to the stock based on moves in the options market lately. That is because the July 28th, 2017, $55 Puthad some of the highest implied volatility of all equity options today.

What is Implied Volatility?

Implied volatility shows how much movement the market is expecting in the future. Options with high levels of implied volatility suggest that investors in the underlying stocks are expecting a big move in one direction or the other. It could also mean there is an event coming up soon that may cause a big rally or a huge sell off. However, implied volatility is only one piece of the puzzle when putting together an options trading strategy.

What do the Analysts Think?

Clearly, options traders are pricing in a big move for Puma Biotechnology shares, but what is the fundamental picture for the company? Currently, Puma Biotechnology is a Zacks Rank #3 (Hold) in the Medical-Biomed/Genetics industry that ranks in the Bottom 37% of our Zacks Industry Rank. Over the last 60 days, 2 analysts have increased their earnings estimates for the current quarter, while none have dropped their estimates. The net effect has taken our Zacks Consensus Estimate for the current quarter from loss of $2.33 per shareto a loss of $2.13 in that period.

Given the way analysts feel about Puma Biotechnology right now, this huge implied volatility could mean theres a trade developing. Often times, options traders look for options with high levels of implied volatility to sell premium. This is a strategy many seasoned traders use because it captures decay. At expiration, the hope for these traders is that the underlying stock does not move as much as originally expected.

Looking to Trade Options?

Each week, our very own Dave Bartosiak gives his top options trades. Check out his recent live analysis and options trade for the TSLA earnings report completely free. See it here: Tesla Earnings Preview with Options Trade Ideas or check out the embedded video below for more details:

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Are Options Traders Betting on a Big Move in Puma Biotechnology (PBYI) Stock? July 03, 2017 - Zacks.com

Nanotechnology is one of the most promising technologies in 21st century. Nanotechnology is a term used when technological developments occur at 0.1 to 100 nm scale. Nano medicine is a branch of nanotechnology which involves medicine development at molecular scale for diagnosis, prevention, treatment of diseases and even regeneration of tissues and organs. Thus it helps to preserve and improve human health. Nanomedicine offers an impressive solution for various life threatening diseases such as cancer, Parkinson, Alzheimer, diabetes, orthopedic problems, diseases related to blood, lungs, neurological, and cardiovascular system.

Development of a new nenomedicine takes several years which are based on various technologies such as dendrimers, micelles, nanocrystals, fullerenes, virosome nanoparticles, nanopores, liposomes, nanorods, nanoemulsions, quantum dots, and nanorobots.

In the field of diagnosis, nanotechnology based methods are more precise, reliable and require minimum amount of biological sample which avoid considerable reduction in consumption of reagents and disposables. Apart from diagnosis, nanotechnology is more widely used in drug delivery purpose due to nanoscale particles with larger surface to volume ratio than micro and macro size particle responsible for higher drug loading. Nano size products allow to enter into body cavities for diagnosis or treatment with minimum invasiveness and increased bioavailability. This will not only improve the efficacy of treatment and diagnosis, but also reduces the side effects of drugs in case of targeted therapy.

Global nanomedicine market is majorly segmented on the basis of applications in medicines, targeted disease and geography. Applications segment includes drug delivery (carrier), drugs, biomaterials, active implant, in-vitro diagnostic, and in-vivo imaging. Global nanomedicine divided on the basis of targeted diseases or disorders in following segment: neurology, cardiovascular, oncology, anti-inflammatory, anti-infective and others. Geographically, nanomedicine market is classified into North America, Europe, Asia Pacific, Latin America, and MEA. Considering nanomedicine market by application, drug delivery contribute higher followed by in-vitro diagnostics. Global nanomedicine market was dominated by oncology segment in 2012 due to ability of nanomedicine to cross body barriers and targeted to tumors specifically however cardiovascular nanomedicine market is fastest growing segment. Geographically, North America dominated the market in 2013 and is expected to maintain its position in the near future. Asia Pacific market is anticipated to grow at faster rate due to rapid increase in geriatric population and rising awareness regarding health care. Europe is expected to grow at faster rate than North America due to extensive product pipeline portfolio and constantly improving regulatory framework.

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Major drivers for nanomedicine market include improved regulatory framework, increasing technological know-how and research funding, rising government support and continuous increase in the prevalence of chronic diseases such as obesity, diabetes, cancer, kidney disorder, and orthopedic diseases. Some other driving factors include rising number of geriatric population, awareness of nanomedicine application and presence of high unmet medical needs. Growing demand of nanomedicines from the end users is expected to drive the market in the forecast period. However, market entry of new companies is expected to bridge the gap between supply and demand of nanomedicines. Above mentioned drivers currently outweigh the risk associated with nanomedicines such as toxicity and high cost. At present, cancer is one of the major targeted areas in which nanomedicines have made contribution. Doxil, Depocyt, Abraxane, Oncospar, and Neulasta are some of the examples of pharmaceuticals formulated using nanotechnology.

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Key players in the global nanomedicine market include: Abbott Laboratories, CombiMatrix Corporation, GE Healthcare, Sigma-Tau Pharmaceuticals, Inc., Johnson & Johnson, Mallinckrodt plc, Merck & Company, Inc., Nanosphere, Inc., Pfizer, Inc., Celgene Corporation, Teva Pharmaceutical Industries Ltd., and UCB (Union chimique belge) S.A.

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Healthcare Nanotechnology (Nanomedicine) Market Expected to Generate Huge Profits by 2015 2021: Persistence ... - MilTech

Researchers at London, UK-based Imperial College are developing a technology to transport drugs directly to the lungs of pulmonary arterial hypertension (PAH) patients.

The technology consists of ethanol-heated iron and trans-trans muconic acid nanoparticles that can be small molecule drug actives.

These particles can be delivered directly to the site of the disease according to lead researcher Jane Mitchell, who told us the targeted approach bypasses the toxicity issues that have held back development of less targeted, systemic nanomedicines.

One of the biggest limitations in nanomedicine is toxicity, some of the best nanomedicine structures do not make it past the initial stages of development, as they kill cells, said Mitchell.

However in a study published in Pulmonary Circulation , researchers explain that these metallic structures - called metal organic frameworks (MOF) are not harmful to cells.

We made these prototype MOFs, and have shown they were not toxic to a whole range of human lung cells, Mitchell told us.

The hope is that using this approach will ultimately allow for high concentrations of drugs we already have, to be delivered to only the vessels in the lung, and reduce side effects, she said.

Pulmonary arterial hypertension (PAH)

PAH is a rare lung disease caused by changes to the smaller branches of the pulmonary arteries. The artery walls thicken, and eventually cause organ failure.

While no cure exists, treatments that open up blood vessels in the artery wall are available. According to Mitchell, these treatments can produce negative side effects.

The drugs available [for PAH]are all small molecule drugs which are seriously limited by systemic side effects. Therefore delivering these drugs to the site of disease in our metal organic frame-work (MOF) carrier would represent a paradigm step forward in technology to treat this disease, she said.

Further, researchers believe the MOF technology has therapeutic benefits of its own.

We know that the carriers can havetherapeutic benefits intheir own right such as reducing inflammation and, in the case of ourformation, the potential for imaging, said Mitchell.

For patients with PAH, it could mean we are able to turn it from a fatal condition, to a chronic manageable one, she said.

According to Mitchell, the technology is not expensive at the experimental level, and would be scaled up at commercial level.

We now need to perform proof of concept studies using carriers containing drugs in cell and animal based models. With funding, this will be complete within 2 years, she Mitchell.

Upon completion of clinical trials, the University hopes to license out the technology.

Link:
Nanoparticle delivery tech targets rare lung disease - In-PharmaTechnologist.com

BBC News

6.8m genetic medicine plan for targeted treatment - BBC News BBC News Patients in Wales will benefit from stronger services and more expertise in genetic medicine, under a new strategy. The 6.8m plan has been designed to ensure ... Tories ask for government assurances over genetic medicine pledge ...Barry and District News Government strategy strives for tailor-made healthcarePenarth Times all 4 news articles »

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6.8m genetic medicine plan for targeted treatment - BBC News - BBC News

Precision medicine is hot and Konica Minolta wants a piece of the action. To that end, its Healthcare Americas arm is paying $1 billion to acquire Ambry Genetics.

Innovation Network Corporation of Japan (INCJ) is helping to fund the deal.Konica Minolta Healthcare Americas and INCJwill make an all-cash payment of $800 million. Ambry shareholders will get up to $200 million over the next two years.

Konica views the deal as a stepping stone marking its debut as a player in the space and plans to bring Ambrys products to Japan and then to Europe, according to a news release. Shoei Yamana, Konica Minolta CEO said in a news release that the deal marks the first in a series of initiatives to build Konicas precision medicine profile.

The future of medicine is patient-focused. Together with Ambry, we will have the most comprehensive set of diagnostic technologies for mapping an individuals genetic and biochemical makeup, as well as the capabilities to translate that knowledge into information the medical community can use to discover, prevent, and cost-effectively treat diseases, Yamana said. This will not only serve as the future foundation for our healthcare business but will pave the way for a fundamental shift in the way medicine is practiced globally.

Ambrys diagnostic offerings span multiple fields, including neurology, oncology and womens health. As with most genomics services, the business will also be generating rich data as a byproduct of its sales. Konica may be able to tap into this information in myriad ways, from drug discovery to companion diagnostics and more. Its the foundations of todays precision medicine work.

Photo: maxsattana, Getty Images

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Konica Minolta establishing itself as precision medicine player with $1B Ambry Genetics deal - MedCity News

July 5, 2017 Credit: Cancer Research UK

Cancer patients should have routine access to genetic testing to improve diagnosis and treatment, according to England's chief medical officer.

Despite the UK being a world leader in genomic medicine its full potential is still not being realised, Professor Dame Sally Davies said in a new report.

Davies urged clinicians and the Government to work together and make wider use of new genetic techniques in an attempt to improve cancer survival rates.

Genetic testing can pinpoint the faults in DNA that have led to a cancer forming. Different cancers have different faults, and these determine which treatments may or may not work.

Such testing could lead to patients being diagnosed faster and receiving more targeted or precise treatments.

Davies said that "the age of precision medicine is now" and that the NHS must act quickly to remain world class.

"This technology has the potential to change medicine forever but we need all NHS staff, patients and the public to recognise and embrace its huge potential." said Davies.

Sir Harpal Kumar, Cancer Research UK's chief executive, agreed, saying that it would be a disservice to patients if the UK were slow to respond to innovations in this area.

The report recommends that within 5 years training should be available to current and future clinicians and that all patients should be being offered genomic tests just as readily as they're given MRI scans today.

Davies also called for research and international collaboration to be prioritised, along with investment in research and services so that patients across the country have equal access.

However the report recognises potential challenges such as data protection issues and attitudes of clinicians and the public.

"This timely report from the chief medical officer showcases just how much is now possible in genomics research and care within the NHS," added Sir Kumar.

"Cancer Research UK is determined to streamline research, to find the right clinical trial for cancer patients and to ensure laboratory discoveries benefit patients".

And the design of clinical trials are starting to change. A number of trials are underway, like Cancer Research UK's National Lung Matrix Trial with AstraZeneca and Pfizer, where patients with a certain type of lung cancer are assigned a specific treatment based on the genetic makeup of their cancer.

However, Sir Harpal Kumar stressed that to bring the report's vision to life the Government, the NHS, regulators and research funders need to act together.

Explore further: Adding abiraterone to standard treatment improves prostate cancer survival by 40 percent

Cancer Research UK is partnering with pharmaceutical companies AstraZeneca and Pfizer to create a pioneering clinical trial for patients with advanced lung cancer marking a new era of research into personalised medicines ...

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Greater access to genetic testing needed for cancer diagnosis and ... - Medical Xpress

July 5, 2017 Credit: CC0 Public Domain

Pioneering research using the tropical zebrafish could provide new insights into the genetic basis of myopathy, a type of human muscle disease.

An international research team, led by Professor Philip Ingham FRS, inaugural Director of the University of Exeter's Living Systems Institutehas taken the first steps in determining the central role a specific gene mutation in a poorly characterised human myopathy.

Myopathies are diseases that prevent muscle fibres from functioning properly, causing muscular weakness. At present, there is no single treatment for the disease, as it can develop via a number of different pathways.

One particular type is nemaline myopathy, which primarily affects skeletal muscles and can lead to sufferers experiencing severe feeding and swallowing difficulties as well as limited locomotor activity.

Mutations in a specific gene, called MY018B, have recently been found to be present in people exhibiting symptoms of this disease, but the role these mutations play in muscle fibre integrity has until now been unclear.

In this new research, the Ingham team, based in Singapore and Exeter, has used high-resolution genetic analysis to create a zebrafish model of MYO18B malfunction; this research takes advantage of the remarkable similarity between the genomes of zebrafish and humans,which have more than 70 per cent of their genes in common.

The Singapore/Exeter team found that the MYO18B gene is active specifically in the 'fast-twitch' skeletal muscles of the zebrafish, typically used for powerful bursts of movement. Crucially, by studying fish in which the MYO18B gene is disrupted, they were able to show that it plays an essential role in the assembly of the bundles of actin and myosin filaments that give muscle fibres their contractile properties.

The team believe this new research offers a vital new step towards understanding the cause of myopathy in humans, which in turn could give rise to new, tailored treatments in the future.

The leading research is published in the scientific journal, Genetics.

Professor Ingham, said: "The identification of a MYO18B mutation in zebrafish provides the first direct evidence for its role in human myopathy and gives us a model in which to study the molecular basis of MYO18B function in muscle fibre integrity."

A pioneer in the genetic analysis of development using fruit flies and zebrafish as model systems, Prof Ingham is internationally renowned for his contributions to several influential discoveries in the field of developmental biology over the last century.

This is the latest research by Professor Ingham that has revealed important links between the processes that underpin normal embryonic development and disease.

His co-discovery of the 'Sonic Hedgehog' gene, recognised as one of 24 centennial milestones in the field of developmental biology by Nature, in 2004, led directly to the establishment of a biotechnology company that helped develop the first drug to target non-melanoma skin cancer.

The research comes at the University of Exeter holds the official opening of the Living Systems Institute with an Opening Symposium event, from July 5-6 2017.

Two Nobel Laureates, Sir Paul Nurse FRS and Christiane Nsslein-Volhard ForMemRS, who separately won the Nobel Prize for Physiology or Medicine, will deliver keynote speeches as part of the opening event.

The high-profile event, held at the University's Streatham Campus marks the official opening of the LSIa 52 million inter-disciplinary research facility designed to bring new, crucial insights into the causes and preventions of some of the most serious diseases facing humanity.

A Zebrafish Model for a Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B is published in Genetics.

Explore further: Zebrafish help identify mutant gene in rare muscle disease

Journal reference: Genetics

Provided by: University of Exeter

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Research could give insight into genetic basis of of the human muscle disease, myopathy - Medical Xpress

Politics The school's state funding was slated to be cut under the state budget released in February this year By Haley Suh 18 hours ago Photo: Yolanda Chen / The Daily Pennsylvanian

The School of Veterinary Medicine, which for months appeared to be on the verge of losing millions in state funding, will almost certainly have its funding from Harrisburg remain in place, according to the latest updates from the state budget negotiations.

In the Pennsylvania state budget for the upcoming fiscal year, funding for Penn close to 90 percent of which goes to the Vet School was slated to be cut. The Vet School stood to lose almost $30 million, which constitutes 20 percent of their total budget.

This funding now looks like it might be restored by a bill that allocates $30.1 million from the state budget to the Vet School and over $281 thousand to the Division of Infectious Diseases at Penn Medicine.

The state Senate has already voted unanimously for the bill to pass and the House of Representatives will vote on the bill later this week, University spokesperson Stephen MacCarthy said in a statement.

We are grateful to the Senate for unanimously voting to restore funding for the School of Veterinary Medicine and look forward to continuing to advocate for the House of Representatives to support restoration, MacCarthy said.

The bill comes after advocates urged the government to reconsider the restoration of funding that Democratic Gov. Tom Wolf proposed eliminating in his budget address in February. Wolfs cut came as a surprise to the Vet School, which has received funding from the state for the past 133 years.

Vet School Dean Joan Hendricks wrote a letter earlier this month to the editor of The Pike County Courier, a newspaper in the northeastern part of Pennsylvania, urging people to recognize the vital role that veterinarians play in not just providing care for companion animals, but also in protecting the food supply and public health.

Hendricks cited the Vet Schools ability to fight re-emerging threats such as rabies, [help] farmers and truckers see where [swine virus] is present to prevent its spread, and ensure that 99.99 percent of Pennsylvania eggs [make] it to market without salmonella.

She also noted that Penn Vet was the only school of veterinary medicine in Pennsylvania.

Richard Ebert, president of the Pennsylvania Farm Bureau, which provides legislative support and services to farmers in the state, also spoke out against the cut in funding. Ebert wrote to the Centre Daily Times, a periodical based out of State College, Pa., urging state lawmakers to support the restoration of state funding to Penn Vet. He cited the organizations role in studying diseases that could influence human health.

As a dairy farmer, I couldnt imagine losing access to Penn Vets world-class research, food protection programs, and veterinarian care, Ebert wrote. Thats why were calling on the state general assembly to fund this critical support system of agriculture.

Mark ONeill, director of communications at the Pennsylvania Farm Bureau, said in an email that the organization was concerned that a loss of funding would diminish the Vet Schools strong focus on Pennsylvania agriculture, as well as its partnership with the State Department of Agriculture and Penn State University to monitor animal diseases.

ONeill also wrote that farmers were concerned the loss would hurt Penns ability to attract, train, and produce large animal veterinarians, who are decreasing in numbers in Pennsylvania and across the U.S.

Excerpt from:
Penn Vet may keep its $30 million in state funding after all - The Daily Pennsylvanian